BLASTP 2.2.17 [Aug-26-2007]
Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Reference for composition-based statistics:
Schäffer, Alejandro A., L. Aravind, Thomas L. Madden,
Schaffer, Alejandro A., L. Aravind, Thomas L. Madden,
Sergei Shavirin, John L. Spouge, Yuri I. Wolf,
Eugene V. Koonin, and Stephen F. Altschul (2001),
"Improving the accuracy of PSI-BLAST protein database searches with
composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005.
Query= EAN79468.1__[Trypanosoma_brucei]
(555 letters)
Database: nr.pal
6,348,806 sequences; 2,166,943,470 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|71755331|ref|XP_828580.1| fumarate hydratase class I [Tr... 1155 0.0
gi|71403443|ref|XP_804521.1| fumarate hydratase, putative [... 983 0.0
gi|71657162|ref|XP_817100.1| fumarate hydratase, putative [... 983 0.0
gi|154338147|ref|XP_001565298.1| fumarate hydratase, putati... 887 0.0
gi|157869997|ref|XP_001683549.1| fumarate hydratase, putati... 887 0.0
gi|114328471|ref|YP_745628.1| fumarate hydratase [Granuliba... 714 0.0
gi|21223417|ref|NP_629196.1| fumarate hydratase class I [St... 709 0.0
gi|163793371|ref|ZP_02187346.1| Fumarate hydratase class I ... 707 0.0
gi|115696756|ref|XP_782370.2| PREDICTED: similar to SJCHGC0... 707 0.0
gi|34541093|ref|NP_905572.1| fumarate hydratase class I, an... 706 0.0
gi|108757029|ref|YP_631365.1| fumarate hydratase, class I [... 706 0.0
gi|148260340|ref|YP_001234467.1| hydro-lyase, Fe-S type, ta... 705 0.0
gi|56757195|gb|AAW26769.1| SJCHGC09380 protein [Schistosoma... 705 0.0
gi|145345330|ref|XP_001417167.1| predicted protein [Ostreoc... 702 0.0
gi|169199502|ref|ZP_02858786.1| hydro-lyase, Fe-S type, tar... 702 0.0
gi|73536886|ref|XP_847862.1| fumarate hydratase, putative [... 700 0.0
gi|29829760|ref|NP_824394.1| fumarate hydratase class I [St... 699 0.0
gi|167522904|ref|XP_001745789.1| predicted protein [Monosig... 699 0.0
gi|116252450|ref|YP_768288.1| utative fumarate hydratase cl... 699 0.0
gi|71651689|ref|XP_814517.1| fumarate hydratase, putative [... 698 0.0
gi|146093223|ref|XP_001466723.1| fumarate hydratase [Leishm... 698 0.0
gi|154341168|ref|XP_001566537.1| fumarate hydratase, putati... 697 0.0
gi|94469897|gb|ABF20402.1| fumarate hydratase [Leishmania t... 697 0.0
gi|94469895|gb|ABF20401.1| fumarate hydratase [Leishmania i... 697 0.0
gi|94469883|gb|ABF20395.1| fumarate hydratase [Leishmania i... 697 0.0
gi|167362889|ref|ZP_02297379.1| hydro-lyase, Fe-S type, tar... 696 0.0
gi|94469845|gb|ABF20376.1| fumarate hydratase [Leishmania i... 696 0.0
gi|156934140|ref|YP_001438056.1| hypothetical protein ESA_0... 696 0.0
gi|72387235|ref|XP_844042.1| fumarate hydratase, putative [... 695 0.0
gi|71658956|ref|XP_821204.1| fumarate hydratase, putative [... 695 0.0
gi|152970068|ref|YP_001335177.1| fumarase A (fumarate hydra... 695 0.0
gi|94469889|gb|ABF20398.1| fumarate hydratase [Leishmania d... 695 0.0
gi|152970098|ref|YP_001335207.1| fumarase B (fumarate hydra... 693 0.0
gi|146312206|ref|YP_001177280.1| hydro-lyase, Fe-S type, ta... 693 0.0
gi|123441169|ref|YP_001005156.1| fumarate hydratase, class ... 692 0.0
gi|153950524|ref|YP_001402228.1| fumarate hydratase, class ... 692 0.0
gi|170682150|ref|YP_001743642.1| fumarate hydratase [Escher... 692 0.0
gi|26250935|ref|NP_756975.1| Fumarate hydratase class I, an... 692 0.0
gi|24113001|ref|NP_707511.1| fumarase A, fumarate hydratase... 692 0.0
gi|159477070|ref|XP_001696634.1| fumarate hydratase [Chlamy... 692 0.0
gi|16123488|ref|NP_406801.1| fumarate hydratase, class I [Y... 691 0.0
gi|16129570|ref|NP_416129.1| fumarate hydratase (fumarase A... 691 0.0
gi|110805586|ref|YP_689106.1| Fumarate hydratase class I, a... 691 0.0
gi|77975942|ref|ZP_00831475.1| COG1951: Tartrate dehydratas... 691 0.0
gi|94469869|gb|ABF20388.1| fumarate hydratase [Leishmania i... 691 0.0
gi|74312063|ref|YP_310482.1| fumarase A [Shigella sonnei Ss... 691 0.0
gi|83571002|ref|ZP_00922444.1| COG1951: Tartrate dehydratas... 691 0.0
gi|160891324|ref|ZP_02072327.1| hypothetical protein BACUNI... 691 0.0
gi|170025619|ref|YP_001722124.1| hydro-lyase, Fe-S type, ta... 690 0.0
gi|170681722|ref|YP_001746516.1| fumarate hydratase class I... 690 0.0
gi|162448627|ref|YP_001610994.1| hypothetical protein sce03... 689 0.0
gi|82777081|ref|YP_403430.1| fumarase A [Shigella dysenteri... 689 0.0
gi|167765038|ref|ZP_02437159.1| hypothetical protein BACSTE... 689 0.0
gi|77961334|ref|ZP_00825174.1| COG1951: Tartrate dehydratas... 689 0.0
gi|86358000|ref|YP_469892.1| fumarate hydratase class I pro... 689 0.0
gi|15802026|ref|NP_288047.1| fumarase A = fumarate hydratas... 689 0.0
gi|77958707|ref|ZP_00822736.1| COG1951: Tartrate dehydratas... 689 0.0
gi|111022862|ref|YP_705834.1| fumarate hydratase class I [R... 688 0.0
gi|74314608|ref|YP_313027.1| fumarase B [Shigella sonnei Ss... 688 0.0
gi|170021880|ref|YP_001726834.1| hydro-lyase, Fe-S type, ta... 687 0.0
gi|170769931|ref|ZP_02904384.1| fumarate hydratase class I,... 687 0.0
gi|50119846|ref|YP_049013.1| fumarate hydratase class I, ae... 687 0.0
gi|83587247|ref|ZP_00925876.1| COG1951: Tartrate dehydratas... 687 0.0
gi|54025175|ref|YP_119417.1| putative fumarate hydratase [N... 687 0.0
gi|150004412|ref|YP_001299156.1| anaerobic fumarate hydrata... 687 0.0
gi|16131948|ref|NP_418546.1| anaerobic class I fumarate hyd... 686 0.0
gi|163759690|ref|ZP_02166775.1| Fumarate lyase:Fe-S type hy... 686 0.0
gi|23501844|ref|NP_697971.1| fumarate hydratase, class I [B... 686 0.0
gi|17987299|ref|NP_539933.1| FUMARATE HYDRATASE CLASS I, AE... 686 0.0
gi|82546623|ref|YP_410570.1| fumarase B [Shigella boydii Sb... 686 0.0
gi|15834358|ref|NP_313131.1| fumarase B [Escherichia coli O... 686 0.0
gi|168707429|ref|ZP_02739706.1| fumarase B [Escherichia col... 686 0.0
gi|75238651|ref|ZP_00722640.1| COG1951: Tartrate dehydratas... 686 0.0
gi|170768741|ref|ZP_02903194.1| fumarate hydratase [Escheri... 686 0.0
gi|146311487|ref|YP_001176561.1| hydro-lyase, Fe-S type, ta... 685 0.0
gi|77979700|ref|ZP_00835117.1| COG1951: Tartrate dehydratas... 685 0.0
gi|146048|gb|AAA23827.1| anaerobic class I fumarase (EC 4.2... 685 0.0
gi|53711966|ref|YP_097958.1| anaerobic fumarate hydratase c... 685 0.0
gi|118590296|ref|ZP_01547699.1| Fumarate lyase [Stappia agg... 685 0.0
gi|110807879|ref|YP_691399.1| Fumarate hydratase class I, a... 684 0.0
gi|536967|gb|AAA97022.1| fumarase [Escherichia coli] 684 0.0
gi|117926517|ref|YP_867134.1| hydro-lyases, Fe-S type, tart... 684 0.0
gi|144897727|emb|CAM74591.1| Tartrate dehydratase alpha sub... 684 0.0
gi|24115309|ref|NP_709819.1| fumarase B, fumarate hydratase... 684 0.0
gi|167752638|ref|ZP_02424765.1| hypothetical protein ALIPUT... 684 0.0
gi|134098364|ref|YP_001104025.1| fumarate hydratase class I... 684 0.0
gi|163843229|ref|YP_001627633.1| hydro-lyase, Fe-S type, ta... 684 0.0
gi|161618915|ref|YP_001592802.1| hydro-lyase, Fe-S type, ta... 684 0.0
gi|157145872|ref|YP_001453190.1| hypothetical protein CKO_0... 683 0.0
gi|116057093|emb|CAL51520.1| fumarate hydratase class I (IS... 683 0.0
gi|15804714|ref|NP_290755.1| fumarase B= fumarate hydratase... 683 0.0
gi|160885089|ref|ZP_02066092.1| hypothetical protein BACOVA... 683 0.0
gi|168221268|ref|ZP_02646500.1| hypothetical protein Senter... 682 0.0
gi|167979141|ref|ZP_02561418.1| fumarase B [Salmonella ente... 682 0.0
gi|148560002|ref|YP_001258929.1| fumarate hydratase, class ... 682 0.0
gi|170788734|gb|EDT29778.1| fumarate hydratase class I, ana... 681 0.0
gi|83310430|ref|YP_420694.1| Fumarate hydratase class I aer... 681 0.0
gi|157147942|ref|YP_001455261.1| hypothetical protein CKO_0... 681 0.0
gi|145596754|ref|YP_001161051.1| hydro-lyase, Fe-S type, ta... 680 0.0
gi|153009555|ref|YP_001370770.1| hydro-lyase, Fe-S type, ta... 680 0.0
>gi|71755331|ref|XP_828580.1| fumarate hydratase class I [Trypanosoma brucei TREU927]
gi|70833966|gb|EAN79468.1| fumarate hydratase class I, putative [Trypanosoma brucei]
Length = 555
Score = 1155 bits (2988), Expect = 0.0, Method: Composition-based stats.
Identities = 555/555 (100%), Positives = 555/555 (100%)
Query: 1 MLRRSSLWFAPKSAPPFKFVPLLPHLHHKDTEYTLVTKDYVSVVNPGAGLPEILKVEAAG 60
MLRRSSLWFAPKSAPPFKFVPLLPHLHHKDTEYTLVTKDYVSVVNPGAGLPEILKVEAAG
Sbjct: 1 MLRRSSLWFAPKSAPPFKFVPLLPHLHHKDTEYTLVTKDYVSVVNPGAGLPEILKVEAAG 60
Query: 61 LTLLASRAIGDVQHFLRPSHLASLRSIFEDPEASDNDRFVALQLIKNANIAAARILPGCQ 120
LTLLASRAIGDVQHFLRPSHLASLRSIFEDPEASDNDRFVALQLIKNANIAAARILPGCQ
Sbjct: 61 LTLLASRAIGDVQHFLRPSHLASLRSIFEDPEASDNDRFVALQLIKNANIAAARILPGCQ 120
Query: 121 DTGTAIIAGYKGEQVFTNGDDEEALSRGVHHIYTTTNLRYSQNVPLTMYDEKNTGCNLPA 180
DTGTAIIAGYKGEQVFTNGDDEEALSRGVHHIYTTTNLRYSQNVPLTMYDEKNTGCNLPA
Sbjct: 121 DTGTAIIAGYKGEQVFTNGDDEEALSRGVHHIYTTTNLRYSQNVPLTMYDEKNTGCNLPA 180
Query: 181 QIDLYATKGCEYEFFFVAKGGGSANKAFLFQETKSVLNPKSLRNFLEEKISTIGTSACPP 240
QIDLYATKGCEYEFFFVAKGGGSANKAFLFQETKSVLNPKSLRNFLEEKISTIGTSACPP
Sbjct: 181 QIDLYATKGCEYEFFFVAKGGGSANKAFLFQETKSVLNPKSLRNFLEEKISTIGTSACPP 240
Query: 241 YHMAVVVGGTSAEMTMKAVKYASCKYLDELPTKPDESKGYTYRDLEMEQMVMDICRNIGM 300
YHMAVVVGGTSAEMTMKAVKYASCKYLDELPTKPDESKGYTYRDLEMEQMVMDICRNIGM
Sbjct: 241 YHMAVVVGGTSAEMTMKAVKYASCKYLDELPTKPDESKGYTYRDLEMEQMVMDICRNIGM 300
Query: 301 GAQFGGKYFAHDARVIRMPRHGASCPIGIGVSCSADRQALAKINKDGIWVEKLEMDPAKY 360
GAQFGGKYFAHDARVIRMPRHGASCPIGIGVSCSADRQALAKINKDGIWVEKLEMDPAKY
Sbjct: 301 GAQFGGKYFAHDARVIRMPRHGASCPIGIGVSCSADRQALAKINKDGIWVEKLEMDPAKY 360
Query: 361 LPEVTEDQLLKVPPVKIDLNMPMDKIRAELSRHPVKTRLSLTGTIIVARDIAHARMREML 420
LPEVTEDQLLKVPPVKIDLNMPMDKIRAELSRHPVKTRLSLTGTIIVARDIAHARMREML
Sbjct: 361 LPEVTEDQLLKVPPVKIDLNMPMDKIRAELSRHPVKTRLSLTGTIIVARDIAHARMREML 420
Query: 421 ENNKPLPDYIKNHPVYYAGPAKRPEALASGSFGPTTAGRMDPFVDLFQANGGSFVMLAKG 480
ENNKPLPDYIKNHPVYYAGPAKRPEALASGSFGPTTAGRMDPFVDLFQANGGSFVMLAKG
Sbjct: 421 ENNKPLPDYIKNHPVYYAGPAKRPEALASGSFGPTTAGRMDPFVDLFQANGGSFVMLAKG 480
Query: 481 NRSKRVTEACKKYGGFYLGSIGGPAALLAMDSIRKVEVLDMEELGMEAVWKIEVENFPAF 540
NRSKRVTEACKKYGGFYLGSIGGPAALLAMDSIRKVEVLDMEELGMEAVWKIEVENFPAF
Sbjct: 481 NRSKRVTEACKKYGGFYLGSIGGPAALLAMDSIRKVEVLDMEELGMEAVWKIEVENFPAF 540
Query: 541 IVVDDKGNDFFQQLR 555
IVVDDKGNDFFQQLR
Sbjct: 541 IVVDDKGNDFFQQLR 555
>gi|71403443|ref|XP_804521.1| fumarate hydratase, putative [Trypanosoma cruzi strain CL Brener]
gi|70867538|gb|EAN82670.1| fumarate hydratase, putative [Trypanosoma cruzi]
Length = 555
Score = 983 bits (2542), Expect = 0.0, Method: Composition-based stats.
Identities = 469/555 (84%), Positives = 507/555 (91%)
Query: 1 MLRRSSLWFAPKSAPPFKFVPLLPHLHHKDTEYTLVTKDYVSVVNPGAGLPEILKVEAAG 60
MLRRS+ K+ PFK+VPL+PH+ H DT + L+TKDYVSVV PG GLPEIL+V+ G
Sbjct: 1 MLRRSAAALGKKAPVPFKYVPLIPHVSHDDTPFRLLTKDYVSVVRPGCGLPEILQVDVEG 60
Query: 61 LTLLASRAIGDVQHFLRPSHLASLRSIFEDPEASDNDRFVALQLIKNANIAAARILPGCQ 120
L LAS A GDVQH LRPSHLASLR IF+DPEASDNDRFVALQL+KNANIAAAR+LPGCQ
Sbjct: 61 LAKLASEAFGDVQHLLRPSHLASLRRIFDDPEASDNDRFVALQLLKNANIAAARVLPGCQ 120
Query: 121 DTGTAIIAGYKGEQVFTNGDDEEALSRGVHHIYTTTNLRYSQNVPLTMYDEKNTGCNLPA 180
DTGTAI+AGYKGEQVFTNGD+ EALSRGV+ IYTTTNLRYSQNVPLTM+DEKNTG NLPA
Sbjct: 121 DTGTAIVAGYKGEQVFTNGDECEALSRGVYKIYTTTNLRYSQNVPLTMFDEKNTGSNLPA 180
Query: 181 QIDLYATKGCEYEFFFVAKGGGSANKAFLFQETKSVLNPKSLRNFLEEKISTIGTSACPP 240
QIDLYATKG EY F FVAKGGGSANKA+LFQETKSVLNPKSLR FLEEKI IGT+ACPP
Sbjct: 181 QIDLYATKGQEYNFMFVAKGGGSANKAYLFQETKSVLNPKSLRKFLEEKIGAIGTAACPP 240
Query: 241 YHMAVVVGGTSAEMTMKAVKYASCKYLDELPTKPDESKGYTYRDLEMEQMVMDICRNIGM 300
YHMAVVVGGTSAEMT+K VKYASCKY D LPTKPDESKGY YRD EME +VMDIC N+GM
Sbjct: 241 YHMAVVVGGTSAEMTLKTVKYASCKYYDNLPTKPDESKGYAYRDTEMENVVMDICYNMGM 300
Query: 301 GAQFGGKYFAHDARVIRMPRHGASCPIGIGVSCSADRQALAKINKDGIWVEKLEMDPAKY 360
GAQFGGKYFAHDARVIR+PRHGASCPIGIGVSCSADRQALAKINKDGIW+E+LE DPAKY
Sbjct: 301 GAQFGGKYFAHDARVIRLPRHGASCPIGIGVSCSADRQALAKINKDGIWLEQLETDPAKY 360
Query: 361 LPEVTEDQLLKVPPVKIDLNMPMDKIRAELSRHPVKTRLSLTGTIIVARDIAHARMREML 420
LPE+TEDQLLK PPV IDL+MPM+KIRAELS++PVKTRLSL+GTIIVARD+AHARMREML
Sbjct: 361 LPEITEDQLLKTPPVNIDLSMPMEKIRAELSKYPVKTRLSLSGTIIVARDMAHARMREML 420
Query: 421 ENNKPLPDYIKNHPVYYAGPAKRPEALASGSFGPTTAGRMDPFVDLFQANGGSFVMLAKG 480
E KPLP+YIKNHPVYYAGPAK PE + SGSFGPTTAGRMDPFVDLFQANGGSFVMLAKG
Sbjct: 421 EAGKPLPEYIKNHPVYYAGPAKCPEGMPSGSFGPTTAGRMDPFVDLFQANGGSFVMLAKG 480
Query: 481 NRSKRVTEACKKYGGFYLGSIGGPAALLAMDSIRKVEVLDMEELGMEAVWKIEVENFPAF 540
NRS+ VT+ACKK+GGFYLGSIGGPAALLA DSIRKVEVLDM ELGMEAVWKIEVENFPAF
Sbjct: 481 NRSRAVTQACKKHGGFYLGSIGGPAALLAKDSIRKVEVLDMAELGMEAVWKIEVENFPAF 540
Query: 541 IVVDDKGNDFFQQLR 555
IV+DDKGNDFFQQL+
Sbjct: 541 IVLDDKGNDFFQQLK 555
>gi|71657162|ref|XP_817100.1| fumarate hydratase, putative [Trypanosoma cruzi strain CL Brener]
gi|70882271|gb|EAN95249.1| fumarate hydratase, putative [Trypanosoma cruzi]
Length = 555
Score = 983 bits (2540), Expect = 0.0, Method: Composition-based stats.
Identities = 469/555 (84%), Positives = 507/555 (91%)
Query: 1 MLRRSSLWFAPKSAPPFKFVPLLPHLHHKDTEYTLVTKDYVSVVNPGAGLPEILKVEAAG 60
MLRRS+ K+ PFK+VPL+PH+ H DT L+TKDYVSVV PG G+PEIL+V+ G
Sbjct: 1 MLRRSAAALGKKAPVPFKYVPLIPHVSHDDTPLRLLTKDYVSVVRPGCGVPEILQVDVEG 60
Query: 61 LTLLASRAIGDVQHFLRPSHLASLRSIFEDPEASDNDRFVALQLIKNANIAAARILPGCQ 120
LT LAS A GDVQH LRPSHLASLR IF+DPEASDNDRFVALQL+KNANIAAAR+LPGCQ
Sbjct: 61 LTRLASEAFGDVQHLLRPSHLASLRKIFDDPEASDNDRFVALQLLKNANIAAARVLPGCQ 120
Query: 121 DTGTAIIAGYKGEQVFTNGDDEEALSRGVHHIYTTTNLRYSQNVPLTMYDEKNTGCNLPA 180
DTGTAI+AGYKGEQVFTNGD+ EALSRGV+ IYTTTNLRYSQNVPLTM+DEKNTG NLPA
Sbjct: 121 DTGTAIVAGYKGEQVFTNGDECEALSRGVYKIYTTTNLRYSQNVPLTMFDEKNTGSNLPA 180
Query: 181 QIDLYATKGCEYEFFFVAKGGGSANKAFLFQETKSVLNPKSLRNFLEEKISTIGTSACPP 240
QIDLYATKG EY F FVAKGGGSANKA+LFQETKSVLNPKSLR FLEEKI IGT+ACPP
Sbjct: 181 QIDLYATKGQEYNFMFVAKGGGSANKAYLFQETKSVLNPKSLRKFLEEKIGAIGTAACPP 240
Query: 241 YHMAVVVGGTSAEMTMKAVKYASCKYLDELPTKPDESKGYTYRDLEMEQMVMDICRNIGM 300
YHMAVVVGGTSAEMT+K VKYASCKY D LPTKPDESKGY YRD EME +VMDIC N+GM
Sbjct: 241 YHMAVVVGGTSAEMTLKTVKYASCKYYDNLPTKPDESKGYAYRDTEMENVVMDICYNMGM 300
Query: 301 GAQFGGKYFAHDARVIRMPRHGASCPIGIGVSCSADRQALAKINKDGIWVEKLEMDPAKY 360
GAQFGGKYFAHDARVIR+PRHGASCPIGIGVSCSADRQALAKINKDGIW+E+LE DPAKY
Sbjct: 301 GAQFGGKYFAHDARVIRLPRHGASCPIGIGVSCSADRQALAKINKDGIWLEQLETDPAKY 360
Query: 361 LPEVTEDQLLKVPPVKIDLNMPMDKIRAELSRHPVKTRLSLTGTIIVARDIAHARMREML 420
LPE+TEDQLLK PPV IDL+MPM+KIRAELS++PVKTRLSL+GTIIVARD+AHARMREML
Sbjct: 361 LPEITEDQLLKTPPVNIDLSMPMEKIRAELSKYPVKTRLSLSGTIIVARDMAHARMREML 420
Query: 421 ENNKPLPDYIKNHPVYYAGPAKRPEALASGSFGPTTAGRMDPFVDLFQANGGSFVMLAKG 480
E KPLP+YIKNHPVYYAGPAK PE + SGSFGPTTAGRMDPFVDLFQANGGSFVMLAKG
Sbjct: 421 EAGKPLPEYIKNHPVYYAGPAKCPEGMPSGSFGPTTAGRMDPFVDLFQANGGSFVMLAKG 480
Query: 481 NRSKRVTEACKKYGGFYLGSIGGPAALLAMDSIRKVEVLDMEELGMEAVWKIEVENFPAF 540
NRS+ VT+ACKK+GGFYLGSIGGPAALLA DSIRKVEVLDM ELGMEAVWKIEVENFPAF
Sbjct: 481 NRSRAVTQACKKHGGFYLGSIGGPAALLAKDSIRKVEVLDMAELGMEAVWKIEVENFPAF 540
Query: 541 IVVDDKGNDFFQQLR 555
IV+DDKGNDFFQQL+
Sbjct: 541 IVLDDKGNDFFQQLK 555
>gi|154338147|ref|XP_001565298.1| fumarate hydratase, putative [Leishmania braziliensis
MHOM/BR/75/M2904]
gi|134062347|emb|CAM42207.1| fumarate hydratase, putative [Leishmania braziliensis]
Length = 549
Score = 887 bits (2292), Expect = 0.0, Method: Composition-based stats.
Identities = 412/538 (76%), Positives = 481/538 (89%)
Query: 17 FKFVPLLPHLHHKDTEYTLVTKDYVSVVNPGAGLPEILKVEAAGLTLLASRAIGDVQHFL 76
F FVPL+ + HK+T+Y L+ KD+VSVV PGAGLPE+LKV+ A LTLL+S A D++H +
Sbjct: 12 FNFVPLVSKVSHKETKYRLLAKDHVSVVQPGAGLPEMLKVDPAALTLLSSVAFDDIEHLM 71
Query: 77 RPSHLASLRSIFEDPEASDNDRFVALQLIKNANIAAARILPGCQDTGTAIIAGYKGEQVF 136
R SHLASLR IF+DPEASDND+FVALQL+KNANI++AR+LPGCQDTGTAII+G++GEQVF
Sbjct: 72 RSSHLASLRKIFDDPEASDNDKFVALQLLKNANISSARLLPGCQDTGTAIISGHRGEQVF 131
Query: 137 TNGDDEEALSRGVHHIYTTTNLRYSQNVPLTMYDEKNTGCNLPAQIDLYATKGCEYEFFF 196
G++EEALSRGV+ I+ NLRYSQNVPL+MYDEKNTG NLPAQIDLYATKG EY F F
Sbjct: 132 VLGNEEEALSRGVYDIFQERNLRYSQNVPLSMYDEKNTGTNLPAQIDLYATKGMEYSFLF 191
Query: 197 VAKGGGSANKAFLFQETKSVLNPKSLRNFLEEKISTIGTSACPPYHMAVVVGGTSAEMTM 256
VAKGGGSANK+FL QE+KSVLNPKSLR FL+EK++ GTSACPPYH+AVV+GGTSAEMTM
Sbjct: 192 VAKGGGSANKSFLLQESKSVLNPKSLRKFLKEKLAMFGTSACPPYHIAVVIGGTSAEMTM 251
Query: 257 KAVKYASCKYLDELPTKPDESKGYTYRDLEMEQMVMDICRNIGMGAQFGGKYFAHDARVI 316
+ VK+ASC Y D+L TKPD GYT+RDLE+E+ V++IC+NIGMGAQFGGKY+AHDARVI
Sbjct: 252 RMVKHASCHYYDDLITKPDMKTGYTFRDLELEKEVLEICQNIGMGAQFGGKYYAHDARVI 311
Query: 317 RMPRHGASCPIGIGVSCSADRQALAKINKDGIWVEKLEMDPAKYLPEVTEDQLLKVPPVK 376
RMPRHGASCPIGIGVSCSADRQAL KINKDG+W+E LEM+P+++LP+V ED+LLK PPV+
Sbjct: 312 RMPRHGASCPIGIGVSCSADRQALGKINKDGVWLEVLEMEPSRFLPDVKEDELLKTPPVE 371
Query: 377 IDLNMPMDKIRAELSRHPVKTRLSLTGTIIVARDIAHARMREMLENNKPLPDYIKNHPVY 436
++LN PM ++ ELS+HPVKTRLSLTGTI+VARD AHARMREMLE KPLP Y+K+HPVY
Sbjct: 372 VNLNRPMSEVLQELSKHPVKTRLSLTGTIVVARDSAHARMREMLEAGKPLPQYMKDHPVY 431
Query: 437 YAGPAKRPEALASGSFGPTTAGRMDPFVDLFQANGGSFVMLAKGNRSKRVTEACKKYGGF 496
YAGPAK P+ L SGSFGPTTAGRMDPFVDLFQ+ GGS VMLAKGNRSK VTEACKK+GGF
Sbjct: 432 YAGPAKTPDGLPSGSFGPTTAGRMDPFVDLFQSLGGSMVMLAKGNRSKHVTEACKKHGGF 491
Query: 497 YLGSIGGPAALLAMDSIRKVEVLDMEELGMEAVWKIEVENFPAFIVVDDKGNDFFQQL 554
YLGSIGGPAA+LA D+I+KVE LDM++LGMEAVWKIEV+NFPAFIVVDDKGNDFFQQL
Sbjct: 492 YLGSIGGPAAVLAQDAIKKVECLDMKDLGMEAVWKIEVQNFPAFIVVDDKGNDFFQQL 549
>gi|157869997|ref|XP_001683549.1| fumarate hydratase, putative [Leishmania major]
gi|68126615|emb|CAJ04118.1| fumarate hydratase, putative [Leishmania major]
Length = 549
Score = 887 bits (2292), Expect = 0.0, Method: Composition-based stats.
Identities = 418/554 (75%), Positives = 486/554 (87%), Gaps = 5/554 (0%)
Query: 1 MLRRSSLWFAPKSAPPFKFVPLLPHLHHKDTEYTLVTKDYVSVVNPGAGLPEILKVEAAG 60
MLRR AP A F FVPL+ + HK+T+Y L+TKDYVSVV PGAGLPE+L+V+ A
Sbjct: 1 MLRR----LAPLLAE-FNFVPLVSKVSHKETKYRLLTKDYVSVVQPGAGLPEMLRVDPAA 55
Query: 61 LTLLASRAIGDVQHFLRPSHLASLRSIFEDPEASDNDRFVALQLIKNANIAAARILPGCQ 120
LTLL+S A DV+H LR SHL SLR IF+DPEASDND+FVALQL+KNANI++AR+LPGCQ
Sbjct: 56 LTLLSSTAFDDVEHLLRSSHLMSLRKIFDDPEASDNDKFVALQLLKNANISSARLLPGCQ 115
Query: 121 DTGTAIIAGYKGEQVFTNGDDEEALSRGVHHIYTTTNLRYSQNVPLTMYDEKNTGCNLPA 180
DTGTAIIAGY+G+QVF G+DEEALSRGV+ I+ N RYSQNVPL+MYDEKNTG NLPA
Sbjct: 116 DTGTAIIAGYRGDQVFVPGNDEEALSRGVYDIFQKRNFRYSQNVPLSMYDEKNTGTNLPA 175
Query: 181 QIDLYATKGCEYEFFFVAKGGGSANKAFLFQETKSVLNPKSLRNFLEEKISTIGTSACPP 240
QIDLYA+KG EY F FVAKGGGSANK+FL QETKSVLNPKSLRNFL+EK++ GTSACPP
Sbjct: 176 QIDLYASKGMEYSFMFVAKGGGSANKSFLLQETKSVLNPKSLRNFLKEKLAMFGTSACPP 235
Query: 241 YHMAVVVGGTSAEMTMKAVKYASCKYLDELPTKPDESKGYTYRDLEMEQMVMDICRNIGM 300
YH+AVV+GGTSAEMTMK +KYASC Y D+L TKPD GYT+RDLE+E+ V+ +C+NIGM
Sbjct: 236 YHVAVVIGGTSAEMTMKVLKYASCHYYDDLITKPDMKTGYTFRDLELEEEVLKVCQNIGM 295
Query: 301 GAQFGGKYFAHDARVIRMPRHGASCPIGIGVSCSADRQALAKINKDGIWVEKLEMDPAKY 360
GAQFGGKY+AHD RVIRMPRHGASCPIGIGVSCSADRQAL KINKDG+W+E+LEM+P++Y
Sbjct: 296 GAQFGGKYYAHDVRVIRMPRHGASCPIGIGVSCSADRQALGKINKDGVWLEELEMEPSQY 355
Query: 361 LPEVTEDQLLKVPPVKIDLNMPMDKIRAELSRHPVKTRLSLTGTIIVARDIAHARMREML 420
LP++ ED+LLK P V ++LN PM ++ ELS+HPV+TRLSLTGTIIVARD AHARMREML
Sbjct: 356 LPDLKEDELLKTPAVMVNLNRPMPEVLQELSKHPVRTRLSLTGTIIVARDSAHARMREML 415
Query: 421 ENNKPLPDYIKNHPVYYAGPAKRPEALASGSFGPTTAGRMDPFVDLFQANGGSFVMLAKG 480
E KPLP Y+K HPVYYAGPAK+P+ L SGSFGPTTAGRMDPFVDLFQ++GGS VMLAKG
Sbjct: 416 EAGKPLPQYMKEHPVYYAGPAKQPDGLPSGSFGPTTAGRMDPFVDLFQSHGGSMVMLAKG 475
Query: 481 NRSKRVTEACKKYGGFYLGSIGGPAALLAMDSIRKVEVLDMEELGMEAVWKIEVENFPAF 540
NRSK+VT+AC KYGGFYLGSIGGPAA+LA ++I+KVE LDM++LGMEAVW+IEVENFPAF
Sbjct: 476 NRSKQVTKACHKYGGFYLGSIGGPAAVLAQNAIKKVECLDMKDLGMEAVWRIEVENFPAF 535
Query: 541 IVVDDKGNDFFQQL 554
IVVDDKGNDFF+QL
Sbjct: 536 IVVDDKGNDFFEQL 549
>gi|114328471|ref|YP_745628.1| fumarate hydratase [Granulibacter bethesdensis CGDNIH1]
gi|114316645|gb|ABI62705.1| fumarate hydratase [Granulibacter bethesdensis CGDNIH1]
Length = 550
Score = 714 bits (1842), Expect = 0.0, Method: Composition-based stats.
Identities = 355/549 (64%), Positives = 424/549 (77%), Gaps = 10/549 (1%)
Query: 11 PKSA-PPFKFVPLLPHLHHKDTEYTLVTKDYVSVVNPGAGLPEILKVEAAGLTLLASRAI 69
P +A P F + P+ P L H +T + + + V IL + LT LA A
Sbjct: 6 PNAAFPGFAYSPMFP-LTHDETVWRKLDIGGLRVSEHEG--RRILHIAPEALTELARTAF 62
Query: 70 GDVQHFLRPSHLASLRSIFEDPEASDNDRFVALQLIKNANIAAARILPGCQDTGTAIIAG 129
DV H LRP+HLA LR I +DPEAS NDRFVAL L+KNANIAA +LP CQDTGTAI+ G
Sbjct: 63 HDVAHLLRPAHLAQLRRILDDPEASANDRFVALDLLKNANIAAGGVLPMCQDTGTAIVFG 122
Query: 130 YKGEQVFTNGDDEEALSRGVHHIYTTTNLRYSQNVPLTMYDEKNTGCNLPAQIDLYATKG 189
KG+ V+ GD+EEALS GVH YT TNLRYSQ PLTMY+EKNTG NLP Q D+ A G
Sbjct: 123 KKGQHVWVEGDEEEALSLGVHRTYTETNLRYSQMAPLTMYEEKNTGNNLPVQFDILAVPG 182
Query: 190 C----EYEFFFVAKGGGSANKAFLFQETKSVLNPKSLRNFLEEKISTIGTSACPPYHMAV 245
E++ FVAKGGGSANK FLFQET++VL+P+ L FLE KI T+GTSACPPYH+A+
Sbjct: 183 GHHADEFQLMFVAKGGGSANKTFLFQETRAVLSPEKLLPFLETKIRTLGTSACPPYHLAI 242
Query: 246 VVGGTSAEMTMKAVKYASCKYLDELPTKPDESKGYTYRDLEMEQMVMDICRNIGMGAQFG 305
V+GGTSAE T+K VK AS K+LD LPT+ D + G+ +RDLE+EQ V+++ R+IG+GAQFG
Sbjct: 243 VIGGTSAETTLKTVKLASTKWLDTLPTQGDMT-GHAFRDLELEQQVLELTRSIGIGAQFG 301
Query: 306 GKYFAHDARVIRMPRHGASCPIGIGVSCSADRQALAKINKDGIWVEKLEMDPAKYLPEVT 365
GKYF HD RV+R+PRHGAS PI IGVSCSADRQ AKI +G+++E+LE DPA++LPE T
Sbjct: 302 GKYFCHDVRVVRLPRHGASLPIAIGVSCSADRQVRAKITPEGVFLEQLETDPARFLPEAT 361
Query: 366 EDQLLKVPPVKIDLNMPMDKIRAELSRHPVKTRLSLTGTIIVARDIAHARMREMLENNKP 425
+D +L V+IDLN PMD+IRA LS+HPVKTRLSLTGT++VARDIAHA++ E LE +
Sbjct: 362 DD-ILGGEVVRIDLNRPMDEIRAALSKHPVKTRLSLTGTVVVARDIAHAKLAERLEAGEG 420
Query: 426 LPDYIKNHPVYYAGPAKRPEALASGSFGPTTAGRMDPFVDLFQANGGSFVMLAKGNRSKR 485
LPDYIKNHPVYYAGPAK P+ + +GSFGPTTAGRMD +VD FQ GGSFVMLAKGNRSK
Sbjct: 421 LPDYIKNHPVYYAGPAKTPDGMPTGSFGPTTAGRMDSYVDAFQKAGGSFVMLAKGNRSKA 480
Query: 486 VTEACKKYGGFYLGSIGGPAALLAMDSIRKVEVLDMEELGMEAVWKIEVENFPAFIVVDD 545
V +ACK YGGFYLGS+GGPAA LA D IRKVEVL+ ELGMEAVWKIEVE+FPAFIV+DD
Sbjct: 481 VRDACKTYGGFYLGSVGGPAARLAQDCIRKVEVLEYPELGMEAVWKIEVEDFPAFIVIDD 540
Query: 546 KGNDFFQQL 554
KGNDFF+ L
Sbjct: 541 KGNDFFEGL 549
>gi|21223417|ref|NP_629196.1| fumarate hydratase class I [Streptomyces coelicolor A3(2)]
gi|9967671|emb|CAC05889.1| fumarate hydratase class I [Streptomyces coelicolor A3(2)]
Length = 558
Score = 709 bits (1831), Expect = 0.0, Method: Composition-based stats.
Identities = 348/539 (64%), Positives = 424/539 (78%), Gaps = 5/539 (0%)
Query: 15 PPFKFVPLLPHLHHKDTEYTLVTKDYVSVVNPGAGLPEILKVEAAGLTLLASRAIGDVQH 74
P F + LLP T Y LVT + V+ A LKVE L LA A+ D+QH
Sbjct: 5 PEFAYTDLLPQ-GEDTTPYRLVTAEGVATFE--ADGRTFLKVEPEALRKLAEEAVHDIQH 61
Query: 75 FLRPSHLASLRSIFEDPEASDNDRFVALQLIKNANIAAARILPGCQDTGTAIIAGYKGEQ 134
+LRP+HLA LR I +DPEAS ND+FVAL L+KNANIAAA +LP CQDTGTAI+ G +G+
Sbjct: 62 YLRPAHLAQLRRIIDDPEASGNDKFVALDLLKNANIAAAGVLPMCQDTGTAIVMGKRGQN 121
Query: 135 VFTNGDDEEALSRGVHHIYTTTNLRYSQNVPLTMYDEKNTGCNLPAQIDLYATKGCEYEF 194
V T G DEEALSRG++ Y NLRYSQ PLTM++EKNTG NLPAQI+LYAT G Y+F
Sbjct: 122 VLTEGGDEEALSRGIYDAYKNLNLRYSQMAPLTMWEEKNTGSNLPAQIELYATDGGAYKF 181
Query: 195 FFVAKGGGSANKAFLFQETKSVLNPKSLRNFLEEKISTIGTSACPPYHMAVVVGGTSAEM 254
F+AKGGGSANK+FL+QETK+VLN S+ FLEEKI ++GT+ACPPYH+A+VVGGTSAE
Sbjct: 182 LFMAKGGGSANKSFLYQETKAVLNESSMMKFLEEKIRSLGTAACPPYHLAIVVGGTSAEY 241
Query: 255 TMKAVKYASCKYLDELPTKPDESKGYTYRDLEMEQMVMDICRNIGMGAQFGGKYFAHDAR 314
+K KYAS YLDE+P + E G+ +RD E+E+ V ++ + IG+GAQFGGKYF HD R
Sbjct: 242 ALKTAKYASAHYLDEIPAEGSE-LGHGFRDKELEEKVFELTQKIGIGAQFGGKYFCHDVR 300
Query: 315 VIRMPRHGASCPIGIGVSCSADRQALAKINKDGIWVEKLEMDPAKYLPEVTEDQLLKVPP 374
V+R+PRHGASCP+ I VSCSADRQA+AKI +G+++E+LE DPA++LPE T++ L +
Sbjct: 301 VVRLPRHGASCPVAIAVSCSADRQAVAKITAEGVFLEQLETDPARFLPETTDEHLEEEGD 360
Query: 375 -VKIDLNMPMDKIRAELSRHPVKTRLSLTGTIIVARDIAHARMREMLENNKPLPDYIKNH 433
VK+DLN PMD I AEL+RHPVKTRLSLTG ++VARDIAHA+++E L+ + +P Y+K+H
Sbjct: 361 VVKVDLNQPMDDILAELTRHPVKTRLSLTGPLVVARDIAHAKIKERLDAGEEMPQYLKDH 420
Query: 434 PVYYAGPAKRPEALASGSFGPTTAGRMDPFVDLFQANGGSFVMLAKGNRSKRVTEACKKY 493
PVYYAGPAK PE ASGSFGPTTAGRMD +V+ FQA GGS VMLAKGNRSK+VT+AC +
Sbjct: 421 PVYYAGPAKTPEGYASGSFGPTTAGRMDSYVEQFQAAGGSKVMLAKGNRSKQVTDACDAH 480
Query: 494 GGFYLGSIGGPAALLAMDSIRKVEVLDMEELGMEAVWKIEVENFPAFIVVDDKGNDFFQ 552
GGFYLGSIGGPAA LA D I+KVEV++ EELGMEAVWKIEVE+FPAFIVVDDKGNDFFQ
Sbjct: 481 GGFYLGSIGGPAARLAQDCIKKVEVVEYEELGMEAVWKIEVEDFPAFIVVDDKGNDFFQ 539
>gi|163793371|ref|ZP_02187346.1| Fumarate hydratase class I aerobic [alpha proteobacterium BAL199]
gi|159181173|gb|EDP65688.1| Fumarate hydratase class I aerobic [alpha proteobacterium BAL199]
Length = 554
Score = 707 bits (1824), Expect = 0.0, Method: Composition-based stats.
Identities = 342/542 (63%), Positives = 419/542 (77%), Gaps = 5/542 (0%)
Query: 13 SAPPFKFVPLLPHLHHKDTEYTLVTKDYVSVVNPGAGLPEILKVEAAGLTLLASRAIGDV 72
+ P F F + P L TEY +T D+VSV G E++ VE LTLLA +A D+
Sbjct: 18 AMPAFDFTEMFP-LGPDTTEYRKLTSDHVSV--SALGGREVVSVEPEALTLLAEQAFRDI 74
Query: 73 QHFLRPSHLASLRSIFEDPEASDNDRFVALQLIKNANIAAARILPGCQDTGTAIIAGYKG 132
H LRP HL LR+I +DP+AS NDRFVA L+KNA+IAA +LP CQDTGTAI+ G KG
Sbjct: 75 SHLLRPGHLQQLRNILDDPDASPNDRFVAYDLLKNASIAAGGVLPMCQDTGTAIVMGKKG 134
Query: 133 EQVFTNGDDEEALSRGVHHIYTTTNLRYSQNVPLTMYDEKNTGCNLPAQIDLYATKGCEY 192
+ +FT DDEEALSRG+ + Y TNLRYSQ PL M+ EKNT NLPAQ++LYA KG Y
Sbjct: 135 QNIFTGFDDEEALSRGIFNTYVNTNLRYSQLAPLDMFAEKNTASNLPAQVELYADKGDAY 194
Query: 193 EFFFVAKGGGSANKAFLFQETKSVLNPKSLRNFLEEKISTIGTSACPPYHMAVVVGGTSA 252
+F F+ KGGGSANK FL+Q+TK+VLNP SL FL+EKI T+GTSACPPYH+A+V+GGTSA
Sbjct: 195 KFLFIQKGGGSANKTFLYQQTKAVLNPDSLAKFLDEKIRTLGTSACPPYHLAIVIGGTSA 254
Query: 253 EMTMKAVKYASCKYLDELPTKPDESKGYTYRDLEMEQMVMDICRNIGMGAQFGGKYFAHD 312
E +K VK AS +YLD LPT E+ G+ YRDLE EQ ++ + R +G+GAQFGGKYF HD
Sbjct: 255 EFNLKTVKLASTRYLDGLPTAGSET-GHAYRDLEWEQKILQMTREMGIGAQFGGKYFCHD 313
Query: 313 ARVIRMPRHGASCPIGIGVSCSADRQALAKINKDGIWVEKLEMDPAKYLPEVTEDQLLKV 372
RVIR+PRHGASCPIGIGVSCSADRQA AKI +DG+++E+LE DPA++LP++ E+ L
Sbjct: 314 VRVIRLPRHGASCPIGIGVSCSADRQATAKITRDGVYLERLESDPARFLPDIDENA-LTA 372
Query: 373 PPVKIDLNMPMDKIRAELSRHPVKTRLSLTGTIIVARDIAHARMREMLENNKPLPDYIKN 432
V+IDL PM++IR LS+ P+KTR+SL+G +IVARDIAHA+++E+++ KPLPDY+KN
Sbjct: 373 DAVEIDLTRPMEEIRRTLSQFPIKTRVSLSGPMIVARDIAHAKLQELIDAGKPLPDYVKN 432
Query: 433 HPVYYAGPAKRPEALASGSFGPTTAGRMDPFVDLFQANGGSFVMLAKGNRSKRVTEACKK 492
HP+YYAGPAK P ASGSFGPTTAGRMD +V F A GGSFV LAKGNRS V EACKK
Sbjct: 433 HPIYYAGPAKTPAGYASGSFGPTTAGRMDSYVGPFMAAGGSFVTLAKGNRSPMVREACKK 492
Query: 493 YGGFYLGSIGGPAALLAMDSIRKVEVLDMEELGMEAVWKIEVENFPAFIVVDDKGNDFFQ 552
+GGFYLGS+GG AA LA++ I+KVEV + ELGMEAVW+IEVE FPAFIVVDDKGNDFF
Sbjct: 493 HGGFYLGSVGGAAAKLALNCIKKVEVQEFPELGMEAVWRIEVEKFPAFIVVDDKGNDFFA 552
Query: 553 QL 554
+
Sbjct: 553 NI 554
>gi|115696756|ref|XP_782370.2| PREDICTED: similar to SJCHGC09380 protein [Strongylocentrotus
purpuratus]
gi|115928730|ref|XP_001185576.1| PREDICTED: similar to SJCHGC09380 protein [Strongylocentrotus
purpuratus]
Length = 1049
Score = 707 bits (1824), Expect = 0.0, Method: Composition-based stats.
Identities = 331/538 (61%), Positives = 427/538 (79%), Gaps = 4/538 (0%)
Query: 16 PFKFVPLLPHLHHKDTEYTLVTKDYVSVVNPGAGLPEILKVEAAGLTLLASRAIGDVQHF 75
PF + + H +DT + +T D+VS + +IL+V+ LT+LAS+A+ D+ H
Sbjct: 512 PFIYQDVFEPDHARDTPFKKLTGDFVSTIEVEG--RKILRVKPEALTMLASQAMIDIAHL 569
Query: 76 LRPSHLASLRSIFEDPEASDNDRFVALQLIKNANIAAARILPGCQDTGTAIIAGYKGEQV 135
LRP HL LR+I +DPEAS NDRFV+L+L+KNAN+A+A +LPGCQDTGTAI+ G +G+ V
Sbjct: 570 LRPKHLQQLRNILDDPEASSNDRFVSLELLKNANVASAMVLPGCQDTGTAIMMGKRGQNV 629
Query: 136 FTNGDDEEALSRGVHHIYTTTNLRYSQNVPLTMYDEKNTGCNLPAQIDLYATKGCEYEFF 195
+T+ DEE LSRGV++ YT NLRYSQ PL M+ E NTG NLPAQI+LYA G EY F
Sbjct: 630 WTDERDEEHLSRGVYNTYTQKNLRYSQVSPLDMFKEANTGTNLPAQIELYAVPGNEYHFL 689
Query: 196 FVAKGGGSANKAFLFQETKSVLNPKSLRNFLEEKISTIGTSACPPYHMAVVVGGTSAEMT 255
F+AKGGGSANK FL+Q+TK++LN + L F+ EKI TIGT+ACPPYH++ VVGG SAEMT
Sbjct: 690 FIAKGGGSANKTFLYQQTKALLNKEKLMAFVNEKIKTIGTAACPPYHLSFVVGGLSAEMT 749
Query: 256 MKAVKYASCKYLDELPTKPDESKGYTYRDLEMEQMVMDICRNIGMGAQFGGKYFAHDARV 315
+K VK AS KY D LPT +E G +RD+E+E+ + ++ + +G+GAQFGGKYF HD RV
Sbjct: 750 LKTVKMASTKYYDTLPTTGNE-HGRAFRDVELEKEIHELSQQLGIGAQFGGKYFCHDVRV 808
Query: 316 IRMPRHGASCPIGIGVSCSADRQALAKINKDGIWVEKLEMDPAKYLPEVTEDQLLKVPPV 375
IR+PRHGASCP+G+GVSCSADRQA+ KI ++G+++E+LE +P KYLPEV E L +
Sbjct: 809 IRLPRHGASCPVGLGVSCSADRQAIGKITEEGVFLEQLETNPIKYLPEVQEGD-LSGEVI 867
Query: 376 KIDLNMPMDKIRAELSRHPVKTRLSLTGTIIVARDIAHARMREMLENNKPLPDYIKNHPV 435
K++LN PM+ I A L++HP++TR+SLTGT++VARDIAHA+++E L+ + LP Y+K+HPV
Sbjct: 868 KVNLNQPMEDILATLTQHPIRTRISLTGTLVVARDIAHAKLQERLDAGEELPQYMKDHPV 927
Query: 436 YYAGPAKRPEALASGSFGPTTAGRMDPFVDLFQANGGSFVMLAKGNRSKRVTEACKKYGG 495
YYAGPAK PE ASGSFGPTTAGRMD +V+ FQA GGS VMLAKGNRSK VT+ACK +GG
Sbjct: 928 YYAGPAKTPEGYASGSFGPTTAGRMDSYVNSFQAAGGSKVMLAKGNRSKDVTKACKTHGG 987
Query: 496 FYLGSIGGPAALLAMDSIRKVEVLDMEELGMEAVWKIEVENFPAFIVVDDKGNDFFQQ 553
FYLGSIGGPAA+LA D I+KVEVL+ EELGMEA+W+++VE+FPAFIVVDDKGNDFF++
Sbjct: 988 FYLGSIGGPAAILAQDCIKKVEVLEYEELGMEAIWRVDVEDFPAFIVVDDKGNDFFKK 1045
>gi|34541093|ref|NP_905572.1| fumarate hydratase class I, anaerobic [Porphyromonas gingivalis
W83]
gi|34397408|gb|AAQ66471.1| fumarate hydratase class I, anaerobic [Porphyromonas gingivalis
W83]
Length = 548
Score = 706 bits (1822), Expect = 0.0, Method: Composition-based stats.
Identities = 338/543 (62%), Positives = 422/543 (77%), Gaps = 5/543 (0%)
Query: 13 SAPPFKFVPLLPHLHHKDTEYTLVTKDYVSVVNPGAGLPEILKVEAAGLTLLASRAIGDV 72
+ P FK+ P + TEY L+TK+YVSV G ++LKVE L LLA A D+
Sbjct: 2 ATPEFKYQKPFP-MGDDTTEYYLLTKEYVSVDKFGDH--DVLKVEPEALRLLARTAFHDI 58
Query: 73 QHFLRPSHLASLRSIFEDPEASDNDRFVALQLIKNANIAAARILPGCQDTGTAIIAGYKG 132
+LRP H + I DPEAS+ND+FVAL ++NA ++A LP CQDTGTAII G KG
Sbjct: 59 AFYLRPEHQQQVARILSDPEASENDKFVALTFLRNAEVSAKGQLPFCQDTGTAIILGKKG 118
Query: 133 EQVFTNGDDEEALSRGVHHIYTTTNLRYSQNVPLTMYDEKNTGCNLPAQIDLYATKGCEY 192
+QV+T G DEE LS GV+ YT NLRYSQN PL MY E NTGCNLPAQIDL A G EY
Sbjct: 119 QQVWTGGHDEEQLSHGVYDTYTQENLRYSQNAPLDMYKEVNTGCNLPAQIDLMAVDGMEY 178
Query: 193 EFFFVAKGGGSANKAFLFQETKSVLNPKSLRNFLEEKISTIGTSACPPYHMAVVVGGTSA 252
+F +AKGGGSANK +L+QETK++LNPK+L NFL +K+S++GT+ACPPYH+A V+GGTSA
Sbjct: 179 DFLCIAKGGGSANKTYLYQETKALLNPKTLVNFLVDKMSSLGTAACPPYHIAFVIGGTSA 238
Query: 253 EMTMKAVKYASCKYLDELPTKPDESKGYTYRDLEMEQMVMDICRNIGMGAQFGGKYFAHD 312
E +K VK AS KY D LPT +E G +RD+E+E+ V++ ++G+GAQFGGKYFAHD
Sbjct: 239 ETNLKTVKLASAKYYDNLPTSGNEG-GRAFRDVELEKEVLEAAYHLGLGAQFGGKYFAHD 297
Query: 313 ARVIRMPRHGASCPIGIGVSCSADRQALAKINKDGIWVEKLEMDPAKYLPEVTEDQLLKV 372
R+IR+PRHGASCP+G+GVSCSADR AKINKDGIW+EK+E +P + +PE + +
Sbjct: 298 VRIIRLPRHGASCPVGMGVSCSADRNIKAKINKDGIWIEKMETNPTRLIPESMREGT-EG 356
Query: 373 PPVKIDLNMPMDKIRAELSRHPVKTRLSLTGTIIVARDIAHARMREMLENNKPLPDYIKN 432
VK+DLN PM +I ELS++PV TRLSL+GTIIV RDIAHA+++E ++ + LPDYIKN
Sbjct: 357 TVVKVDLNRPMPEILRELSQYPVSTRLSLSGTIIVGRDIAHAKLKERIDRGEGLPDYIKN 416
Query: 433 HPVYYAGPAKRPEALASGSFGPTTAGRMDPFVDLFQANGGSFVMLAKGNRSKRVTEACKK 492
HP+YYAGPAK P+ + SGSFGPTTAGRMD +VDLFQ++GGS VM+AKGNRS++VT+ACKK
Sbjct: 417 HPIYYAGPAKTPKGMPSGSFGPTTAGRMDSYVDLFQSHGGSMVMIAKGNRSQQVTDACKK 476
Query: 493 YGGFYLGSIGGPAALLAMDSIRKVEVLDMEELGMEAVWKIEVENFPAFIVVDDKGNDFFQ 552
YGGFYLGS+GGPAA+LA DSI+KVE L+ ELGMEA+WKIEVE+FPAFI+VDDKGNDFF
Sbjct: 477 YGGFYLGSVGGPAAILAQDSIKKVECLEYPELGMEAIWKIEVEDFPAFILVDDKGNDFFT 536
Query: 553 QLR 555
Q+R
Sbjct: 537 QIR 539
>gi|108757029|ref|YP_631365.1| fumarate hydratase, class I [Myxococcus xanthus DK 1622]
gi|108460909|gb|ABF86094.1| fumarate hydratase, class I [Myxococcus xanthus DK 1622]
Length = 569
Score = 706 bits (1821), Expect = 0.0, Method: Composition-based stats.
Identities = 348/544 (63%), Positives = 422/544 (77%), Gaps = 5/544 (0%)
Query: 11 PKSAPPFKFVPLLPHLHHKDTEYTLVTKDYVSVVNPGAGLPEILKVEAAGLTLLASRAIG 70
P F+F +LP L +T Y L++KD+VS AG L+V LTLL A+
Sbjct: 22 PTGMTDFQFQDMLP-LGKDETPYRLLSKDHVSTFE--AGGRTFLQVAPEALTLLTREAMR 78
Query: 71 DVQHFLRPSHLASLRSIFEDPEASDNDRFVALQLIKNANIAAARILPGCQDTGTAIIAGY 130
D+ H LRP HL L I EDPEAS NDRFVAL+L+KNANIAA +LP CQDTGTAI+ G
Sbjct: 79 DIAHLLRPGHLKQLSHILEDPEASSNDRFVALELLKNANIAAGGVLPSCQDTGTAIVMGK 138
Query: 131 KGEQVFTNGDDEEALSRGVHHIYTTTNLRYSQNVPLTMYDEKNTGCNLPAQIDLYATKGC 190
KG+ V T G+DEEA+SRGV Y T+NLRYSQ PL MY E NTG NLPAQI+LYAT G
Sbjct: 139 KGQYVITGGNDEEAISRGVFETYQTSNLRYSQMAPLDMYKEVNTGNNLPAQIELYATDGD 198
Query: 191 EYEFFFVAKGGGSANKAFLFQETKSVLNPKSLRNFLEEKISTIGTSACPPYHMAVVVGGT 250
Y+F F+AKGGGSANK++LFQETK++LNP+SL NF++ KI ++GT+ACPPYH+A+V+GGT
Sbjct: 199 AYKFLFMAKGGGSANKSYLFQETKALLNPQSLLNFVDAKIRSLGTAACPPYHLAIVIGGT 258
Query: 251 SAEMTMKAVKYASCKYLDELPTKPDESKGYTYRDLEMEQMVMDICRNIGMGAQFGGKYFA 310
SAE +K KYAS +YLD LPT+ ++ G +RD+ +EQ ++ + + G+GAQFGGKYF
Sbjct: 259 SAEYALKTAKYASARYLDSLPTEGNK-LGRGFRDVALEQEILKLTQRTGIGAQFGGKYFC 317
Query: 311 HDARVIRMPRHGASCPIGIGVSCSADRQALAKINKDGIWVEKLEMDPAKYLPEVTEDQLL 370
HD RVIR+PRHGASCP+ I VSCSADRQ L KI +DGI++E+LE DPAKYLPE T+ + L
Sbjct: 318 HDVRVIRLPRHGASCPVAIAVSCSADRQILGKITQDGIFLEQLEADPAKYLPETTDGE-L 376
Query: 371 KVPPVKIDLNMPMDKIRAELSRHPVKTRLSLTGTIIVARDIAHARMREMLENNKPLPDYI 430
VKIDLN PM +IRAELSR+P+KTRLSL+G ++VARDIAHA+++E+L+ +P Y+
Sbjct: 377 GGEVVKIDLNRPMSEIRAELSRYPIKTRLSLSGPLVVARDIAHAKIKEVLDAGNGMPQYL 436
Query: 431 KNHPVYYAGPAKRPEALASGSFGPTTAGRMDPFVDLFQANGGSFVMLAKGNRSKRVTEAC 490
K++ VYYAGPAK PE ASGSFGPTTAGRMD +VD FQA GGSFVMLAKGNRS VTEAC
Sbjct: 437 KDYMVYYAGPAKTPEGYASGSFGPTTAGRMDAYVDQFQAAGGSFVMLAKGNRSPAVTEAC 496
Query: 491 KKYGGFYLGSIGGPAALLAMDSIRKVEVLDMEELGMEAVWKIEVENFPAFIVVDDKGNDF 550
KK+GGFYLGSIGGPAA LA D I KVEVL+ ELGMEAVWKIEV +FPAFIVVDDKGNDF
Sbjct: 497 KKHGGFYLGSIGGPAARLAKDCITKVEVLEYAELGMEAVWKIEVVDFPAFIVVDDKGNDF 556
Query: 551 FQQL 554
F +
Sbjct: 557 FANI 560
>gi|148260340|ref|YP_001234467.1| hydro-lyase, Fe-S type, tartrate/fumarate subfamily, beta subunit
[Acidiphilium cryptum JF-5]
gi|146402021|gb|ABQ30548.1| fumarase [Acidiphilium cryptum JF-5]
Length = 548
Score = 705 bits (1820), Expect = 0.0, Method: Composition-based stats.
Identities = 343/547 (62%), Positives = 425/547 (77%), Gaps = 9/547 (1%)
Query: 12 KSAPPFKFVPLLPHLHHKDTEYTLVTKDYVSVVNPGAGLPEILKVEAAGLTLLASRAIGD 71
K P F F + P L H DT + + VS + A IL++ L+ LA +A D
Sbjct: 6 KKTPDFAFSTMFP-LGHDDTPWRRLDLGGVSTIE--AAGRTILRIAPETLSALAFQAFHD 62
Query: 72 VQHFLRPSHLASLRSIFEDPEASDNDRFVALQLIKNANIAAARILPGCQDTGTAIIAGYK 131
V H LRP HL LR+I +DPEAS+NDR+VA++ +KNANIAA ILP CQDTGTAI+ G K
Sbjct: 63 VSHLLRPGHLRQLRAILDDPEASENDRYVAMEFLKNANIAAGGILPMCQDTGTAIVFGKK 122
Query: 132 GEQVFTNGDDEEALSRGVHHIYTTTNLRYSQNVPLTMYDEKNTGCNLPAQIDLYATKGC- 190
G++V+ GD+EEA S GV+ YT TNLRYSQ PL+MY+E+NTG NLP Q D+ A G
Sbjct: 123 GQRVWVEGDEEEAFSHGVYRTYTETNLRYSQMAPLSMYEERNTGTNLPVQCDIMAAPGEA 182
Query: 191 ---EYEFFFVAKGGGSANKAFLFQETKSVLNPKSLRNFLEEKISTIGTSACPPYHMAVVV 247
E+E FVAKGGGSANK+FL+QET+++LNPK L F+E K+ T+GT+ACPPYH+A+V+
Sbjct: 183 HAEEFELMFVAKGGGSANKSFLYQETRAILNPKKLLEFIETKVKTLGTAACPPYHLAIVI 242
Query: 248 GGTSAEMTMKAVKYASCKYLDELPTKPDESKGYTYRDLEMEQMVMDICRNIGMGAQFGGK 307
GGTSAE TMK VK AS ++LD LPT+ + G+ +RDLE+E+ ++++ R +G+GAQFGGK
Sbjct: 243 GGTSAETTMKTVKLASTRWLDSLPTQGSPT-GHAFRDLELERQILEMTRRLGIGAQFGGK 301
Query: 308 YFAHDARVIRMPRHGASCPIGIGVSCSADRQALAKINKDGIWVEKLEMDPAKYLPEVTED 367
YF HD RV+R+PRHGAS P+GIGVSCSADRQ AKI ++G+++E+LE DPAKYLPEVT D
Sbjct: 302 YFCHDVRVVRLPRHGASLPVGIGVSCSADRQIRAKITREGVFLEQLETDPAKYLPEVT-D 360
Query: 368 QLLKVPPVKIDLNMPMDKIRAELSRHPVKTRLSLTGTIIVARDIAHARMREMLENNKPLP 427
L V+IDLN PM I AELS+HPVKTR++LTG I+VARDIAHA+++E L+ + LP
Sbjct: 361 THLGGDVVQIDLNRPMADILAELSKHPVKTRVALTGPIVVARDIAHAKLKERLDRGEGLP 420
Query: 428 DYIKNHPVYYAGPAKRPEALASGSFGPTTAGRMDPFVDLFQANGGSFVMLAKGNRSKRVT 487
DYIKNHPVYYAGPAK PE +A+GSFGPTTAGRMD +V+ FQA GGS VMLAKGNRS+ V
Sbjct: 421 DYIKNHPVYYAGPAKTPEGMATGSFGPTTAGRMDSYVEEFQAAGGSLVMLAKGNRSRAVR 480
Query: 488 EACKKYGGFYLGSIGGPAALLAMDSIRKVEVLDMEELGMEAVWKIEVENFPAFIVVDDKG 547
+ACK +GGFYLGSIGGPAA+LA D+IRKVEVL+ ELGMEAVW+IEVENFPAFIVVDDKG
Sbjct: 481 DACKAHGGFYLGSIGGPAAVLARDNIRKVEVLEYPELGMEAVWRIEVENFPAFIVVDDKG 540
Query: 548 NDFFQQL 554
NDFF L
Sbjct: 541 NDFFADL 547
>gi|56757195|gb|AAW26769.1| SJCHGC09380 protein [Schistosoma japonicum]
Length = 565
Score = 705 bits (1819), Expect = 0.0, Method: Composition-based stats.
Identities = 333/555 (60%), Positives = 437/555 (78%), Gaps = 9/555 (1%)
Query: 1 MLRRSSLWFAPKSAPPFKFVPLLP--HLHHKDTEYTLVTKDYVSVVNPGAGLPEILKVEA 58
+LRR+ ++ PF + +L + +T + +T D+VS+ EILK+++
Sbjct: 14 LLRRN---LGSQAVKPFFYQDILQLDKPPYAETPFRKLTGDFVSLKKIDD--KEILKIDS 68
Query: 59 AGLTLLASRAIGDVQHFLRPSHLASLRSIFEDPEASDNDRFVALQLIKNANIAAARILPG 118
L LL+ +A+ DV H LRP+HL SL +I DPEAS+ND+FVAL+L+KNAN+AA +LPG
Sbjct: 69 KALILLSQQAMIDVAHLLRPAHLQSLSNILRDPEASNNDKFVALELLKNANVAAGMVLPG 128
Query: 119 CQDTGTAIIAGYKGEQVFTNGDDEEALSRGVHHIYTTTNLRYSQNVPLTMYDEKNTGCNL 178
CQDTGTAI KG+ V+T+G+D EA+S+G+++ YT++ LRYSQ L M+ EKNTG NL
Sbjct: 129 CQDTGTAICMAKKGQFVWTDGNDAEAISQGIYNTYTSSYLRYSQVAALDMFTEKNTGTNL 188
Query: 179 PAQIDLYATKGCEYEFFFVAKGGGSANKAFLFQETKSVLNPKSLRNFLEEKISTIGTSAC 238
PAQI++Y+T G EY F F+AKGGGSANK FL+Q+TK++LNP SL +F+ EKI T+GT+AC
Sbjct: 189 PAQIEIYSTGGNEYSFLFIAKGGGSANKTFLYQQTKALLNPTSLYSFVNEKIKTLGTAAC 248
Query: 239 PPYHMAVVVGGTSAEMTMKAVKYASCKYLDELPTKPDESKGYTYRDLEMEQMVMDICRNI 298
PPYH+AVVVGGTSAE T+K VK ASCKYLD LP+ +E G +RD E E+ ++ + + +
Sbjct: 249 PPYHLAVVVGGTSAEFTLKTVKLASCKYLDHLPSTGNE-HGRAFRDREAEEKILHLTQKV 307
Query: 299 GMGAQFGGKYFAHDARVIRMPRHGASCPIGIGVSCSADRQALAKINKDGIWVEKLEMDPA 358
G+GAQFGGKYF HD RVIR+PRHGASCP+GIGVSCSADRQ L +I DG+++E+LE DP+
Sbjct: 308 GIGAQFGGKYFCHDVRVIRLPRHGASCPVGIGVSCSADRQILGRITNDGVFLEQLETDPS 367
Query: 359 KYLPEVTEDQLLKVPPVKIDLNMPMDKIRAELSRHPVKTRLSLTGTIIVARDIAHARMRE 418
+YLP+ + +Q L VK++LN+PM +I AELS++P+KTRLSLTGT++VARDIAHA+++E
Sbjct: 368 QYLPDPSLNQ-LPTDVVKVNLNLPMKEILAELSKYPIKTRLSLTGTLVVARDIAHAKIKE 426
Query: 419 MLENNKPLPDYIKNHPVYYAGPAKRPEALASGSFGPTTAGRMDPFVDLFQANGGSFVMLA 478
L++ +P+PDY NHPVYYAGPAK P ASGSFGPTTAGRMD +V FQ GGS +MLA
Sbjct: 427 RLDSGQPMPDYFCNHPVYYAGPAKTPMNYASGSFGPTTAGRMDSYVGQFQQAGGSLIMLA 486
Query: 479 KGNRSKRVTEACKKYGGFYLGSIGGPAALLAMDSIRKVEVLDMEELGMEAVWKIEVENFP 538
KGNRSK VT AC+K+GGFYLGSIGGPAA+LA + I+KVEVL+ ELGMEA+W++EVE+FP
Sbjct: 487 KGNRSKAVTNACRKHGGFYLGSIGGPAAILAQNCIKKVEVLEYPELGMEAIWRVEVEDFP 546
Query: 539 AFIVVDDKGNDFFQQ 553
AFIVVDDKGNDFF++
Sbjct: 547 AFIVVDDKGNDFFKE 561
>gi|145345330|ref|XP_001417167.1| predicted protein [Ostreococcus lucimarinus CCE9901]
gi|144577394|gb|ABO95460.1| predicted protein [Ostreococcus lucimarinus CCE9901]
Length = 560
Score = 702 bits (1812), Expect = 0.0, Method: Composition-based stats.
Identities = 341/523 (65%), Positives = 410/523 (78%), Gaps = 3/523 (0%)
Query: 29 KDTEYTLVTKDYVSVVNPGAGLPEILKVEAAGLTLLASRAIGDVQHFLRPSHLASLRSIF 88
K+ E+ LVT+D V+ GA +KV LT LA+RA+ DV H LRP HL LR I
Sbjct: 36 KEVEWRLVTRDGVTTT-AGADGETYVKVAPEALTALAARAVRDVSHLLRPGHLKQLRGIL 94
Query: 89 EDPEASDNDRFVALQLIKNANIAAARILPGCQDTGTAIIAGYKGEQVFTNGDDEEALSRG 148
+DPEAS NDRFVAL+L+KNA +AA +LPGCQDTGTAI+ G +G +V T+G+DE ALSRG
Sbjct: 95 DDPEASKNDRFVALELLKNACVAAGMVLPGCQDTGTAIVMGKRGGRVLTDGEDERALSRG 154
Query: 149 VHHIYTTTNLRYSQNVPLTMYDEKNTGCNLPAQIDLYATKGCEYEFFFVAKGGGSANKAF 208
V+ Y TTNLRYSQ PLTM++EKNTG NLPAQIDLYATKG EY F F+ KGGGSANK F
Sbjct: 155 VYDTYKTTNLRYSQVAPLTMFEEKNTGSNLPAQIDLYATKGDEYHFQFMTKGGGSANKTF 214
Query: 209 LFQETKSVLNPKSLRNFLEEKISTIGTSACPPYHMAVVVGGTSAEMTMKAVKYASCKYLD 268
LFQ+TK+VLN SL +FLEEKI IGTSACPPYH+A+V+GG SAE +K VK AS +Y D
Sbjct: 215 LFQQTKAVLNEASLLSFLEEKIKNIGTSACPPYHLAIVIGGLSAEQNLKTVKMASARYYD 274
Query: 269 ELPTKPDESKGYTYRDLEMEQMVMDICRNIGMGAQFGGKYFAHDARVIRMPRHGASCPIG 328
L T +E G +RDLE E+ + + + +G+GAQFGGKYF HD RVIR+PRHGASCPIG
Sbjct: 275 NLHTSGNEL-GRAFRDLEWEEKIHKLTQTMGIGAQFGGKYFCHDVRVIRLPRHGASCPIG 333
Query: 329 IGVSCSADRQALAKINKDGIWVEKLEMDPAKYLPEVTEDQLLKVPPVKIDLNMPMDKIRA 388
+GVSCSADRQAL KI KDG+++E LE DP+KYLP+V ED L V +DLN PM +I A
Sbjct: 334 LGVSCSADRQALGKITKDGVFIEALETDPSKYLPDVREDNLSN-EVVHVDLNRPMSEILA 392
Query: 389 ELSRHPVKTRLSLTGTIIVARDIAHARMREMLENNKPLPDYIKNHPVYYAGPAKRPEALA 448
LS V TRL+LTG ++VARDIAHA+++E L+ + LP Y+K+H VYYAGPAK PE +A
Sbjct: 393 TLSACEVTTRLTLTGPLVVARDIAHAKLKEQLDRGEDLPQYMKDHAVYYAGPAKTPEGMA 452
Query: 449 SGSFGPTTAGRMDPFVDLFQANGGSFVMLAKGNRSKRVTEACKKYGGFYLGSIGGPAALL 508
SGSFGPTTAGRMD +VD FQA GGS VMLAKGNRS VT ACK +GGFYLGSIGGPAA+L
Sbjct: 453 SGSFGPTTAGRMDSYVDQFQAAGGSMVMLAKGNRSAAVTRACKTHGGFYLGSIGGPAAIL 512
Query: 509 AMDSIRKVEVLDMEELGMEAVWKIEVENFPAFIVVDDKGNDFF 551
A ++I+KV+VL+ ELGMEAVWKI+VENFPAF+VVDDKG++FF
Sbjct: 513 AQNNIKKVDVLEFPELGMEAVWKIQVENFPAFVVVDDKGHNFF 555
>gi|169199502|ref|ZP_02858786.1| hydro-lyase, Fe-S type, tartrate/fumarate subfamily, beta subunit
[Rhizobium leguminosarum bv. trifolii WSM2304]
gi|169086176|gb|EDS66893.1| hydro-lyase, Fe-S type, tartrate/fumarate subfamily, beta subunit
[Rhizobium leguminosarum bv. trifolii WSM2304]
Length = 535
Score = 702 bits (1812), Expect = 0.0, Method: Composition-based stats.
Identities = 346/524 (66%), Positives = 409/524 (78%), Gaps = 4/524 (0%)
Query: 31 TEYTLVTKDYVSVVNPGAGLPEILKVEAAGLTLLASRAIGDVQHFLRPSHLASLRSIFED 90
T Y ++ DYVSV + EIL VE G+ LLA A D+ H LRP HL L SI +D
Sbjct: 13 TPYRKISGDYVSVDSFKG--QEILTVEPEGIRLLAETAFADINHLLRPGHLKQLASILDD 70
Query: 91 PEASDNDRFVALQLIKNANIAAARILPGCQDTGTAIIAGYKGEQVFTNGDDEEALSRGVH 150
PEA+DNDRFVA L+KNANIAA +LP CQDTGTAII G KG +V+T G D AL+RGV
Sbjct: 71 PEATDNDRFVAYDLLKNANIAAGGVLPMCQDTGTAIIMGKKGRRVWTEGGDTAALARGVM 130
Query: 151 HIYTTTNLRYSQNVPLTMYDEKNTGCNLPAQIDLYATKGCEYEFFFVAKGGGSANKAFLF 210
Y NLRYSQ P+ M++EKNT NLPAQID+Y YEF FVAKGGGSANK FL+
Sbjct: 131 DAYEKKNLRYSQLAPVKMFEEKNTRNNLPAQIDIYEEGTDAYEFLFVAKGGGSANKTFLY 190
Query: 211 QETKSVLNPKSLRNFLEEKISTIGTSACPPYHMAVVVGGTSAEMTMKAVKYASCKYLDEL 270
Q T S+L + +FL+EKI T+GT+ACPPYH+A+V+GGTSAEM +K VK AS +YLDEL
Sbjct: 191 QGTPSLLTHDRMIDFLKEKILTLGTAACPPYHLAIVIGGTSAEMNLKTVKLASTRYLDEL 250
Query: 271 PTKPDESKGYTYRDLEMEQMVMDICRNIGMGAQFGGKYFAHDARVIRMPRHGASCPIGIG 330
PT+ ES G+ +RDLEME+ + + + +G+GAQFGGKYF HD RVIR+PRHGAS PIG+G
Sbjct: 251 PTEGSES-GHAFRDLEMEKEIHRLTQQMGVGAQFGGKYFCHDVRVIRLPRHGASLPIGLG 309
Query: 331 VSCSADRQALAKINKDGIWVEKLEMDPAKYLPEVTEDQLLKVPPVKIDLNMPMDKIRAEL 390
VSCSADRQA KI +DGI++E+LE DP+KY+PE+ E +L + V IDLN PM + AEL
Sbjct: 310 VSCSADRQAKGKITRDGIFIEQLESDPSKYMPEIDEAKLSE-STVHIDLNRPMADVLAEL 368
Query: 391 SRHPVKTRLSLTGTIIVARDIAHARMREMLENNKPLPDYIKNHPVYYAGPAKRPEALASG 450
SRHPVKTRLSLTGTIIVARD+AHA++RE LEN + +P+Y+KNHPVYYAGPAK P ASG
Sbjct: 369 SRHPVKTRLSLTGTIIVARDLAHAKIRERLENGEGMPEYLKNHPVYYAGPAKTPAGYASG 428
Query: 451 SFGPTTAGRMDPFVDLFQANGGSFVMLAKGNRSKRVTEACKKYGGFYLGSIGGPAALLAM 510
SFGPTTAGRMD +VD FQ+ GGS VMLAKGNRS+ V EACKK+GGFYLGSIGGPAA LA
Sbjct: 429 SFGPTTAGRMDSYVDQFQSFGGSMVMLAKGNRSRAVREACKKHGGFYLGSIGGPAARLAQ 488
Query: 511 DSIRKVEVLDMEELGMEAVWKIEVENFPAFIVVDDKGNDFFQQL 554
D IRKVEV + ELGMEAVWKIEVENFPAFIV+DDKGNDFFQ+L
Sbjct: 489 DCIRKVEVFEYPELGMEAVWKIEVENFPAFIVIDDKGNDFFQEL 532
>gi|73536886|ref|XP_847862.1| fumarate hydratase, putative [Leishmania major strain Friedlin]
gi|70799738|gb|AAZ09654.1| fumarate hydratase, putative [Leishmania major strain Friedlin]
Length = 568
Score = 700 bits (1807), Expect = 0.0, Method: Composition-based stats.
Identities = 336/537 (62%), Positives = 417/537 (77%), Gaps = 8/537 (1%)
Query: 19 FVPLLPHLHHKDTEYTLV--TKDYVSVVNPGAGLPEILKVEAAGLTLLASRAIGDVQHFL 76
F P PH H TE+ V ++ YV V + LKV LT+LA RA DV HF
Sbjct: 35 FQPTDPH--HHQTEFAKVEGSEKYVEEVEVFG--RQALKVNPEALTILAHRAFSDVHHFF 90
Query: 77 RPSHLASLRSIFEDPEASDNDRFVALQLIKNANIAAARILPGCQDTGTAIIAGYKGEQVF 136
R HL R EDPEASDNDR+VA L+KNA IAA R+LP CQDTGTAI+ G +GE +
Sbjct: 91 RKDHLEGWRRAIEDPEASDNDRYVATTLLKNACIAAGRVLPSCQDTGTAIVLGKRGELCW 150
Query: 137 TNGDDEEALSRGVHHIYTTTNLRYSQNVPLTMYDEKNTGCNLPAQIDLYATKGCEYEFFF 196
T G+DE+ LS+G+ + Y NLRYSQ L M+ E NTG NLPAQ+DL A G +YEF F
Sbjct: 151 TGGEDEKYLSKGIWNAYRYHNLRYSQTAALDMFKECNTGDNLPAQLDLLAVPGSDYEFLF 210
Query: 197 VAKGGGSANKAFLFQETKSVLNPKSLRNFLEEKISTIGTSACPPYHMAVVVGGTSAEMTM 256
+AKGGGSANKA+L+QETK++LNPKSLR F+EEK+ T+GT+ACPPYH+A+V+GGTSAEMTM
Sbjct: 211 IAKGGGSANKAYLYQETKALLNPKSLRAFIEEKLKTLGTAACPPYHIALVIGGTSAEMTM 270
Query: 257 KAVKYASCKYLDELPTKPDESKGYTYRDLEMEQMVMDICRNIGMGAQFGGKYFAHDARVI 316
K VK ASC+Y D LPT D+ G +RD E E++VM++ + G+GAQFGGKYFAH ARVI
Sbjct: 271 KTVKLASCRYYDSLPTTGDKY-GRAFRDPEWEKIVMEVAQKSGIGAQFGGKYFAHQARVI 329
Query: 317 RMPRHGASCPIGIGVSCSADRQALAKINKDGIWVEKLEMDPAKYLPEVTEDQLLKVPPVK 376
R+PRHGASCP+G+ VSCSADRQ LA INK GI++E+LE +PA+YLP++ E L VK
Sbjct: 330 RLPRHGASCPVGLAVSCSADRQILAHINKSGIYIEQLEQNPAQYLPDIPEVH-LSTTSVK 388
Query: 377 IDLNMPMDKIRAELSRHPVKTRLSLTGTIIVARDIAHARMREMLENNKPLPDYIKNHPVY 436
+DL P+DK+R +LS++PV TR+ L GT+IVARDIAHA+++EM++N +PLP+Y+K P+Y
Sbjct: 389 VDLKRPIDKVRQQLSQYPVGTRVMLNGTLIVARDIAHAKIKEMMDNGEPLPEYMKTSPIY 448
Query: 437 YAGPAKRPEALASGSFGPTTAGRMDPFVDLFQANGGSFVMLAKGNRSKRVTEACKKYGGF 496
YAGPAK PE ASGSFGPTTAGRMD +VDLFQ++GGS++ LAKGNRSK+VT+ACKK+GGF
Sbjct: 449 YAGPAKTPEGYASGSFGPTTAGRMDSYVDLFQSHGGSYITLAKGNRSKQVTDACKKHGGF 508
Query: 497 YLGSIGGPAALLAMDSIRKVEVLDMEELGMEAVWKIEVENFPAFIVVDDKGNDFFQQ 553
YLGSIGGPAA+LA DSI++V L ELGMEAVWKIEVE+FPAFIVVDDKGND + +
Sbjct: 509 YLGSIGGPAAILAKDSIKQVTCLAFPELGMEAVWKIEVEDFPAFIVVDDKGNDMYSK 565
>gi|29829760|ref|NP_824394.1| fumarate hydratase class I [Streptomyces avermitilis MA-4680]
gi|29606869|dbj|BAC70929.1| putative fumarate hydratase class I [Streptomyces avermitilis
MA-4680]
Length = 558
Score = 699 bits (1805), Expect = 0.0, Method: Composition-based stats.
Identities = 343/539 (63%), Positives = 422/539 (78%), Gaps = 5/539 (0%)
Query: 15 PPFKFVPLLPHLHHKDTEYTLVTKDYVSVVNPGAGLPEILKVEAAGLTLLASRAIGDVQH 74
P F + LLP T Y LVT + VS A LKVE L LA AI D+QH
Sbjct: 5 PEFAYTDLLPQ-GEDTTPYRLVTSEGVSTFE--ADGRTFLKVEPEALRKLAEEAIHDIQH 61
Query: 75 FLRPSHLASLRSIFEDPEASDNDRFVALQLIKNANIAAARILPGCQDTGTAIIAGYKGEQ 134
+LRP+HLA LR I +DPEAS ND+FVAL L+KNANIAAA +LP CQDTGTAI+ G +G+
Sbjct: 62 YLRPAHLAQLRRIIDDPEASGNDKFVALDLLKNANIAAAGVLPMCQDTGTAIVMGKRGQN 121
Query: 135 VFTNGDDEEALSRGVHHIYTTTNLRYSQNVPLTMYDEKNTGCNLPAQIDLYATKGCEYEF 194
V T G DE ALSRG++ Y NLRYSQ PLTM++EKNTG NLPAQI+LYAT G Y+F
Sbjct: 122 VLTEGGDESALSRGIYDAYKNLNLRYSQMAPLTMWEEKNTGSNLPAQIELYATDGGAYKF 181
Query: 195 FFVAKGGGSANKAFLFQETKSVLNPKSLRNFLEEKISTIGTSACPPYHMAVVVGGTSAEM 254
F+AKGGGSANK+FL+QETK+VLN S+ FLEEKI ++GT+ACPPYH+A+VVGGTSAE
Sbjct: 182 LFMAKGGGSANKSFLYQETKAVLNEGSMMKFLEEKIRSLGTAACPPYHLAIVVGGTSAEY 241
Query: 255 TMKAVKYASCKYLDELPTKPDESKGYTYRDLEMEQMVMDICRNIGMGAQFGGKYFAHDAR 314
+K KYAS YLDE+P + E G+ +RD ++E+ V ++ + IG+GAQFGGKYF HD R
Sbjct: 242 ALKTAKYASAHYLDEIPAEGSE-LGHGFRDKDLEEKVFELTQKIGIGAQFGGKYFCHDVR 300
Query: 315 VIRMPRHGASCPIGIGVSCSADRQALAKINKDGIWVEKLEMDPAKYLPEVTEDQLLKVPP 374
V+R+PRHGASCP+ I VSCSADRQA+AKI +G+++E+LE DPA++LPE T+D L +
Sbjct: 301 VVRLPRHGASCPVAIAVSCSADRQAVAKITAEGVFLEQLETDPARFLPETTDDHLDESGD 360
Query: 375 -VKIDLNMPMDKIRAELSRHPVKTRLSLTGTIIVARDIAHARMREMLENNKPLPDYIKNH 433
V+IDLN PMD I AEL+++PVKTRLSL+G ++VARDIAHA+++E L+ + +P Y+K+H
Sbjct: 361 VVRIDLNQPMDDILAELTKYPVKTRLSLSGPLVVARDIAHAKIKERLDAGEEMPQYLKDH 420
Query: 434 PVYYAGPAKRPEALASGSFGPTTAGRMDPFVDLFQANGGSFVMLAKGNRSKRVTEACKKY 493
PVYYAGPAK PE ASGSFGPTTAGRMD +V+ FQA GGS VMLAKGNRS +VT AC+ +
Sbjct: 421 PVYYAGPAKTPEGYASGSFGPTTAGRMDSYVEQFQAAGGSKVMLAKGNRSAQVTNACEAH 480
Query: 494 GGFYLGSIGGPAALLAMDSIRKVEVLDMEELGMEAVWKIEVENFPAFIVVDDKGNDFFQ 552
GGFYLGSIGGPAA LA D I+KVEV++ EELGMEAVWKIEVE+FPAF+VVDDKGNDFF+
Sbjct: 481 GGFYLGSIGGPAARLAQDCIKKVEVVEYEELGMEAVWKIEVEDFPAFVVVDDKGNDFFK 539
>gi|167522904|ref|XP_001745789.1| predicted protein [Monosiga brevicollis MX1]
gi|163775590|gb|EDQ89213.1| predicted protein [Monosiga brevicollis MX1]
Length = 574
Score = 699 bits (1805), Expect = 0.0, Method: Composition-based stats.
Identities = 331/503 (65%), Positives = 403/503 (80%), Gaps = 2/503 (0%)
Query: 52 EILKVEAAGLTLLASRAIGDVQHFLRPSHLASLRSIFEDPEASDNDRFVALQLIKNANIA 111
E+L+V LTLL+ +A+ D+ H LRP HL LR I +DPE+S NDRFVAL+L+KNA IA
Sbjct: 70 EVLRVAPEALTLLSEQAMIDIAHLLRPGHLQQLRKILDDPESSKNDRFVALELLKNAQIA 129
Query: 112 AARILPGCQDTGTAIIAGYKGEQVFTNGDDEEALSRGVHHIYTTTNLRYSQNVPLTMYDE 171
A +LPGCQDTGTAI G KG+ V++ GDD EALSRGV + YT NLRYSQ PL M+ E
Sbjct: 130 AGMVLPGCQDTGTAICIGKKGQHVWSTGDDGEALSRGVFNAYTRRNLRYSQVAPLDMFQE 189
Query: 172 KNTGCNLPAQIDLYATKGCEYEFFFVAKGGGSANKAFLFQETKSVLNPKSLRNFLEEKIS 231
KNTG NLPAQI+LY+T G EY F F+AKGGGSANK FLFQ+TK+VLN K L FLEEKI
Sbjct: 190 KNTGSNLPAQIELYSTPGNEYHFQFMAKGGGSANKTFLFQQTKAVLNEKKLEQFLEEKIK 249
Query: 232 TIGTSACPPYHMAVVVGGTSAEMTMKAVKYASCKYLDELPTKPDESKGYTYRDLEMEQMV 291
T+GT+ACPPYH+A+V+GG SAEM +K VK AS +Y D L T +E G +RDLE E+ +
Sbjct: 250 TLGTAACPPYHLAIVIGGLSAEMNLKTVKMASTRYYDNLHTSGNE-MGRAFRDLEWEERI 308
Query: 292 MDICRNIGMGAQFGGKYFAHDARVIRMPRHGASCPIGIGVSCSADRQALAKINKDGIWVE 351
+ +N+G+GAQFGGKYF HD RVIR+PRHGASCPIGIGVSCSADRQAL KI K+G+++E
Sbjct: 309 HKLTQNLGIGAQFGGKYFCHDVRVIRLPRHGASCPIGIGVSCSADRQALGKITKEGVFIE 368
Query: 352 KLEMDPAKYLPEVTEDQL-LKVPPVKIDLNMPMDKIRAELSRHPVKTRLSLTGTIIVARD 410
LE +P +YLPEVTE L K VKI+LN PM+ IR +LS +P++TRLSLTG +IVARD
Sbjct: 369 ALETNPGQYLPEVTESDLGDKAEVVKINLNQPMEDIRKQLSSYPIRTRLSLTGKLIVARD 428
Query: 411 IAHARMREMLENNKPLPDYIKNHPVYYAGPAKRPEALASGSFGPTTAGRMDPFVDLFQAN 470
IAHA+++E +++ + LPDYIKNH +YYAGPAK PE ASGSFGPTTAGRMD +V F N
Sbjct: 429 IAHAKLQERIDSGEGLPDYIKNHIIYYAGPAKTPEGYASGSFGPTTAGRMDSYVGPFMEN 488
Query: 471 GGSFVMLAKGNRSKRVTEACKKYGGFYLGSIGGPAALLAMDSIRKVEVLDMEELGMEAVW 530
GGSF+ LAKGNRSK+VT ACK GGFYLGSIGGPAA+LA++SI+ V+V + ELGMEA+W
Sbjct: 489 GGSFITLAKGNRSKQVTNACKANGGFYLGSIGGPAAILALNSIKNVQVKEYPELGMEAIW 548
Query: 531 KIEVENFPAFIVVDDKGNDFFQQ 553
+I+VE+FPAFIVVDDKGNDFFQ+
Sbjct: 549 EIDVEDFPAFIVVDDKGNDFFQE 571
>gi|116252450|ref|YP_768288.1| utative fumarate hydratase class I, aerobic [Rhizobium
leguminosarum bv. viciae 3841]
gi|115257098|emb|CAK08192.1| utative fumarate hydratase class I, aerobic [Rhizobium
leguminosarum bv. viciae 3841]
Length = 535
Score = 699 bits (1803), Expect = 0.0, Method: Composition-based stats.
Identities = 343/524 (65%), Positives = 411/524 (78%), Gaps = 4/524 (0%)
Query: 31 TEYTLVTKDYVSVVNPGAGLPEILKVEAAGLTLLASRAIGDVQHFLRPSHLASLRSIFED 90
T Y ++ D+VSV EIL VE G+ LLA A D+ H LRP HL L SI +D
Sbjct: 13 TPYRKISGDHVSVDTFKG--QEILTVEPEGIRLLAETAFADINHLLRPGHLKQLASILDD 70
Query: 91 PEASDNDRFVALQLIKNANIAAARILPGCQDTGTAIIAGYKGEQVFTNGDDEEALSRGVH 150
PEA+DNDRFVA L+KNANIAA +LP CQDTGTAII G KG +V+T+G+D AL+RGV
Sbjct: 71 PEATDNDRFVAYDLLKNANIAAGGVLPMCQDTGTAIIMGKKGRRVWTDGEDTAALARGVM 130
Query: 151 HIYTTTNLRYSQNVPLTMYDEKNTGCNLPAQIDLYATKGCEYEFFFVAKGGGSANKAFLF 210
Y NLRYSQ P+ M++EKNT NLPAQID+Y YEF FVAKGGGSANK FL+
Sbjct: 131 DAYEKKNLRYSQLAPVKMFEEKNTRNNLPAQIDIYEEGTDAYEFLFVAKGGGSANKTFLY 190
Query: 211 QETKSVLNPKSLRNFLEEKISTIGTSACPPYHMAVVVGGTSAEMTMKAVKYASCKYLDEL 270
Q T S+L + +FL+EKI T+GT+ACPPYH+A+V+GGTSAEM +K VK AS +YLDEL
Sbjct: 191 QGTPSLLTHDRMIDFLKEKILTLGTAACPPYHLAIVIGGTSAEMNLKTVKLASTRYLDEL 250
Query: 271 PTKPDESKGYTYRDLEMEQMVMDICRNIGMGAQFGGKYFAHDARVIRMPRHGASCPIGIG 330
PT+ ES G+ +RD+EME+ + + + +G+GAQFGGKYF HD RVIR+PRHGAS PIG+G
Sbjct: 251 PTEGSES-GHAFRDVEMEKEIHKLTQQMGVGAQFGGKYFCHDVRVIRLPRHGASLPIGLG 309
Query: 331 VSCSADRQALAKINKDGIWVEKLEMDPAKYLPEVTEDQLLKVPPVKIDLNMPMDKIRAEL 390
VSCSADRQA +I +DGI+VE+LE DP+KY+PE+ E +L + V+IDLN PM ++ AEL
Sbjct: 310 VSCSADRQAKGRITRDGIFVEQLETDPSKYMPEIDEAKLSE-STVRIDLNRPMAEVLAEL 368
Query: 391 SRHPVKTRLSLTGTIIVARDIAHARMREMLENNKPLPDYIKNHPVYYAGPAKRPEALASG 450
SRHPVKTRLSLTGTIIVARD+AHA++RE LE + +PDY+KNHPVYYAGPAK P ASG
Sbjct: 369 SRHPVKTRLSLTGTIIVARDLAHAKIRERLEKGEGMPDYLKNHPVYYAGPAKTPVGYASG 428
Query: 451 SFGPTTAGRMDPFVDLFQANGGSFVMLAKGNRSKRVTEACKKYGGFYLGSIGGPAALLAM 510
SFGPTTAGRMD +VD FQ+ GGS VMLAKGNRS+ V EACKK+GGFYLGSIGGPAA LA
Sbjct: 429 SFGPTTAGRMDSYVDQFQSFGGSMVMLAKGNRSRPVREACKKHGGFYLGSIGGPAARLAQ 488
Query: 511 DSIRKVEVLDMEELGMEAVWKIEVENFPAFIVVDDKGNDFFQQL 554
D IRKVEV + ELGMEAVWKIEVE+FPAFIV+DDKGNDFFQ+L
Sbjct: 489 DCIRKVEVFEYPELGMEAVWKIEVEDFPAFIVIDDKGNDFFQEL 532
>gi|71651689|ref|XP_814517.1| fumarate hydratase, putative [Trypanosoma cruzi strain CL Brener]
gi|70879496|gb|EAN92666.1| fumarate hydratase, putative [Trypanosoma cruzi]
Length = 565
Score = 698 bits (1801), Expect = 0.0, Method: Composition-based stats.
Identities = 340/547 (62%), Positives = 414/547 (75%), Gaps = 6/547 (1%)
Query: 10 APKSAPPFKFVPLL--PHLHHKDTEYTLVTKDYVSVVNPGAGLPEILKVEAAGLTLLASR 67
A SA F + P+ HH +TEY ++ DYV V IL+V+ LT LA +
Sbjct: 22 AKASASEFHYEPIFQPSDPHHDETEYYMLEGDYVKTVEVLG--KTILQVKPEALTALAHQ 79
Query: 68 AIGDVQHFLRPSHLASLRSIFEDPEASDNDRFVALQLIKNANIAAARILPGCQDTGTAII 127
A DV HF R HL+ R I EDPEAS+NDRFVA L++NA +AA R+LP CQDTGTAI+
Sbjct: 80 AFADVHHFFRKDHLSGWRRILEDPEASNNDRFVAHTLLQNACVAAGRVLPACQDTGTAIV 139
Query: 128 AGYKGEQVFTNGDDEEALSRGVHHIYTTTNLRYSQNVPLTMYDEKNTGCNLPAQIDLYAT 187
G +GE +T G+DE+ LS+G+ Y LRYSQ L M+ E NTG NLPAQ DL AT
Sbjct: 140 LGKRGELCWTGGEDEKHLSKGIWDCYMNRYLRYSQTAALDMFKEVNTGNNLPAQFDLLAT 199
Query: 188 KGCEYEFFFVAKGGGSANKAFLFQETKSVLNPKSLRNFLEEKISTIGTSACPPYHMAVVV 247
G EY F F+AKGGGSANKAFL+QETK++LNPKSLR F+E+K+ T+GT+ACPPYH+A+V+
Sbjct: 200 AGNEYHFLFIAKGGGSANKAFLYQETKALLNPKSLREFIEQKLKTLGTAACPPYHIALVI 259
Query: 248 GGTSAEMTMKAVKYASCKYLDELPTKPDESKGYTYRDLEMEQMVMDICRNIGMGAQFGGK 307
GGTSAEMTMK VK ASC+Y D LP +++ G +RDLE E +VMDI G+GAQFGGK
Sbjct: 260 GGTSAEMTMKTVKLASCRYYDSLPITGNKN-GRAFRDLEWEAIVMDIACKSGIGAQFGGK 318
Query: 308 YFAHDARVIRMPRHGASCPIGIGVSCSADRQALAKINKDGIWVEKLEMDPAKYLPEVTED 367
YFAH ARVIR+PRHGASCP+G+GVSCSADRQ LAKI G++VE+L DPA+YLP++
Sbjct: 319 YFAHQARVIRLPRHGASCPVGLGVSCSADRQILAKITPKGVFVERLVRDPAQYLPDLPPS 378
Query: 368 QLLKVPPVKIDLNMPMDKIRAELSRHPVKTRLSLTGTIIVARDIAHARMREMLENNKPLP 427
L V +DLN PM +IR LS++PV TRLSLTGT+IVARDIAHA++ E L NN+ LP
Sbjct: 379 S-LSTNVVNVDLNQPMSEIRKLLSQYPVTTRLSLTGTLIVARDIAHAKIMERLNNNEELP 437
Query: 428 DYIKNHPVYYAGPAKRPEALASGSFGPTTAGRMDPFVDLFQANGGSFVMLAKGNRSKRVT 487
Y+K+HPVYYAGPAK P+ +ASGSFGPTTAGRMD ++ F A GGSFV LAKGNRSK VT
Sbjct: 438 QYMKDHPVYYAGPAKTPKGMASGSFGPTTAGRMDSYICPFMAAGGSFVTLAKGNRSKAVT 497
Query: 488 EACKKYGGFYLGSIGGPAALLAMDSIRKVEVLDMEELGMEAVWKIEVENFPAFIVVDDKG 547
EACKKYGGFYLGSIGG AA+LA ++I+ VEV++ ELGMEAVW+I+V +FPAFIVVDDKG
Sbjct: 498 EACKKYGGFYLGSIGGSAAILAQNNIKNVEVVEFPELGMEAVWRIDVVDFPAFIVVDDKG 557
Query: 548 NDFFQQL 554
NDFF +L
Sbjct: 558 NDFFSKL 564
>gi|146093223|ref|XP_001466723.1| fumarate hydratase [Leishmania infantum]
gi|94469841|gb|ABF20374.1| fumarate hydratase [Leishmania infantum]
gi|94469843|gb|ABF20375.1| fumarate hydratase [Leishmania infantum]
gi|94469847|gb|ABF20377.1| fumarate hydratase [Leishmania infantum]
gi|94469849|gb|ABF20378.1| fumarate hydratase [Leishmania infantum]
gi|94469851|gb|ABF20379.1| fumarate hydratase [Leishmania infantum]
gi|94469853|gb|ABF20380.1| fumarate hydratase [Leishmania infantum]
gi|94469855|gb|ABF20381.1| fumarate hydratase [Leishmania infantum]
gi|94469857|gb|ABF20382.1| fumarate hydratase [Leishmania donovani]
gi|94469859|gb|ABF20383.1| fumarate hydratase [Leishmania donovani]
gi|94469861|gb|ABF20384.1| fumarate hydratase [Leishmania donovani archibaldi]
gi|94469863|gb|ABF20385.1| fumarate hydratase [Leishmania donovani]
gi|94469865|gb|ABF20386.1| fumarate hydratase [Leishmania donovani]
gi|94469867|gb|ABF20387.1| fumarate hydratase [Leishmania infantum]
gi|94469871|gb|ABF20389.1| fumarate hydratase [Leishmania donovani]
gi|94469873|gb|ABF20390.1| fumarate hydratase [Leishmania donovani]
gi|94469875|gb|ABF20391.1| fumarate hydratase [Leishmania infantum]
gi|94469877|gb|ABF20392.1| fumarate hydratase [Leishmania infantum]
gi|94469879|gb|ABF20393.1| fumarate hydratase [Leishmania infantum]
gi|94469881|gb|ABF20394.1| fumarate hydratase [Leishmania infantum]
gi|94469885|gb|ABF20396.1| fumarate hydratase [Leishmania infantum]
gi|94469887|gb|ABF20397.1| fumarate hydratase [Leishmania donovani archibaldi]
gi|94469891|gb|ABF20399.1| fumarate hydratase [Leishmania donovani]
gi|94469893|gb|ABF20400.1| fumarate hydratase [Leishmania infantum]
gi|134071086|emb|CAM69767.1| fumarate hydratase, putative [Leishmania infantum]
Length = 568
Score = 698 bits (1801), Expect = 0.0, Method: Composition-based stats.
Identities = 334/537 (62%), Positives = 419/537 (78%), Gaps = 8/537 (1%)
Query: 19 FVPLLPHLHHKDTEYTLV--TKDYVSVVNPGAGLPEILKVEAAGLTLLASRAIGDVQHFL 76
F P PH H TE+ V ++ YV V ++LKV LT+LA RA DV HF
Sbjct: 35 FQPTDPH--HHQTEFAKVEGSEKYVEEVEVFG--RKVLKVNPEALTILAHRAFSDVHHFF 90
Query: 77 RPSHLASLRSIFEDPEASDNDRFVALQLIKNANIAAARILPGCQDTGTAIIAGYKGEQVF 136
R HL R EDPEASDNDR+VA+ L+KNA IAA R+LP CQDTGTAI+ G +GE +
Sbjct: 91 RKDHLEGWRRAIEDPEASDNDRYVAMTLLKNACIAAGRVLPSCQDTGTAIVLGKRGELCW 150
Query: 137 TNGDDEEALSRGVHHIYTTTNLRYSQNVPLTMYDEKNTGCNLPAQIDLYATKGCEYEFFF 196
T G+DE+ LS+G+ + Y NLRYSQ L M+ E NTG NLPAQ+DL A G +YEF F
Sbjct: 151 TGGEDEKYLSKGIWNAYRYHNLRYSQTAALDMFKECNTGDNLPAQLDLLAVPGSDYEFLF 210
Query: 197 VAKGGGSANKAFLFQETKSVLNPKSLRNFLEEKISTIGTSACPPYHMAVVVGGTSAEMTM 256
+AKGGGSANKA+L+QETK++LNPKSLR F+EEK+ T+GT+ACPPYH+A+V+GGTSAEMTM
Sbjct: 211 IAKGGGSANKAYLYQETKALLNPKSLRAFIEEKLKTLGTAACPPYHIALVIGGTSAEMTM 270
Query: 257 KAVKYASCKYLDELPTKPDESKGYTYRDLEMEQMVMDICRNIGMGAQFGGKYFAHDARVI 316
K VK ASC+Y D LPT D+ G +RD E E++VM++ + G+GAQFGGKYFAH ARVI
Sbjct: 271 KTVKLASCRYYDSLPTTGDKY-GRAFRDPEWEKIVMEVAQKSGIGAQFGGKYFAHQARVI 329
Query: 317 RMPRHGASCPIGIGVSCSADRQALAKINKDGIWVEKLEMDPAKYLPEVTEDQLLKVPPVK 376
R+PRHGASCP+G+ VSCSADRQ LA INK GI++E+LE +PA+YLP++ E + L V
Sbjct: 330 RLPRHGASCPVGLAVSCSADRQILAHINKSGIYIEQLEQNPAQYLPDIPEVR-LSTTSVN 388
Query: 377 IDLNMPMDKIRAELSRHPVKTRLSLTGTIIVARDIAHARMREMLENNKPLPDYIKNHPVY 436
+DL P+D++R +LS++PV TR+ L GT+IVARDIAHA+++EM++N +PLP+Y+K P+Y
Sbjct: 389 VDLKRPIDEVRQQLSQYPVGTRVMLNGTLIVARDIAHAKIKEMMDNGEPLPEYMKTSPIY 448
Query: 437 YAGPAKRPEALASGSFGPTTAGRMDPFVDLFQANGGSFVMLAKGNRSKRVTEACKKYGGF 496
YAGPAK PE ASGSFGPTTAGRMD +VDLFQ++GGS++ LAKGNRSK+VT+ACKK+GGF
Sbjct: 449 YAGPAKTPEGHASGSFGPTTAGRMDSYVDLFQSHGGSYITLAKGNRSKQVTDACKKHGGF 508
Query: 497 YLGSIGGPAALLAMDSIRKVEVLDMEELGMEAVWKIEVENFPAFIVVDDKGNDFFQQ 553
YLGSIGGPAA+LA DSI++V L ELGMEAVWKIEVE+FPAFIVVDDKGND + +
Sbjct: 509 YLGSIGGPAAILAKDSIKEVTCLAFPELGMEAVWKIEVEDFPAFIVVDDKGNDMYSK 565
>gi|154341168|ref|XP_001566537.1| fumarate hydratase, putative [Leishmania braziliensis
MHOM/BR/75/M2904]
gi|134063860|emb|CAM40049.1| fumarate hydratase, putative [Leishmania braziliensis]
Length = 568
Score = 697 bits (1800), Expect = 0.0, Method: Composition-based stats.
Identities = 333/539 (61%), Positives = 423/539 (78%), Gaps = 10/539 (1%)
Query: 19 FVPLLPHLHHKDTEYTLV--TKDYVS-VVNPGAGLPEILKVEAAGLTLLASRAIGDVQHF 75
F P PH H +T++T + ++ YV VV G E+LKV LT++A RA DV HF
Sbjct: 35 FQPTDPH--HHETQFTKIEGSEKYVEEVVVFGR---EVLKVNPEALTIVAHRAYSDVHHF 89
Query: 76 LRPSHLASLRSIFEDPEASDNDRFVALQLIKNANIAAARILPGCQDTGTAIIAGYKGEQV 135
R HL R +DPE+SDNDR+VA+ L+KNA IAA R+LP CQDTGTAI+ G +GE
Sbjct: 90 FRKDHLEGWRRAIDDPESSDNDRYVAMTLLKNACIAAGRVLPSCQDTGTAIVLGKRGELC 149
Query: 136 FTNGDDEEALSRGVHHIYTTTNLRYSQNVPLTMYDEKNTGCNLPAQIDLYATKGCEYEFF 195
+T G+DE+ LS+GV + Y NLRYSQ L M+ E NTG NLPAQ+DL A G YEF
Sbjct: 150 WTGGEDEKYLSKGVWNAYKYHNLRYSQTAALDMFKECNTGDNLPAQLDLLAVPGSGYEFL 209
Query: 196 FVAKGGGSANKAFLFQETKSVLNPKSLRNFLEEKISTIGTSACPPYHMAVVVGGTSAEMT 255
F+AKGGGSANKA+L+QETK++LNPKSLR F+EEK+ T+GT+ACPPYH+A+V+GGTSAEMT
Sbjct: 210 FIAKGGGSANKAYLYQETKALLNPKSLRAFIEEKLKTLGTAACPPYHIALVIGGTSAEMT 269
Query: 256 MKAVKYASCKYLDELPTKPDESKGYTYRDLEMEQMVMDICRNIGMGAQFGGKYFAHDARV 315
MK VK ASC+Y D LPT D+ G +RDLE E +VM++ + G+GAQFGGKYFAH ARV
Sbjct: 270 MKTVKLASCRYYDSLPTTGDK-HGRAFRDLEWEAVVMEVAQKSGIGAQFGGKYFAHQARV 328
Query: 316 IRMPRHGASCPIGIGVSCSADRQALAKINKDGIWVEKLEMDPAKYLPEVTEDQLLKVPPV 375
IR+PRHGASCP+G+ VSCSADRQ LA+INK+GI++E+LE +PA+YLP++T L V
Sbjct: 329 IRLPRHGASCPVGLAVSCSADRQILAQINKNGIYIEQLEENPAQYLPDITTAN-LSTTSV 387
Query: 376 KIDLNMPMDKIRAELSRHPVKTRLSLTGTIIVARDIAHARMREMLENNKPLPDYIKNHPV 435
+DL P+D++R +LS++PV TR+ L GT+IVARD AHA+++E+L++ +PLPDY+K P+
Sbjct: 388 NVDLKRPIDEVRRQLSQYPVGTRVMLNGTLIVARDTAHAKIKEILDSGEPLPDYMKTSPI 447
Query: 436 YYAGPAKRPEALASGSFGPTTAGRMDPFVDLFQANGGSFVMLAKGNRSKRVTEACKKYGG 495
YYAGPAK PE ASGSFGPTTAGRMD +VDLFQ++GGS +MLAKGNRSK+VT+ACKK+GG
Sbjct: 448 YYAGPAKTPEGYASGSFGPTTAGRMDSYVDLFQSHGGSHIMLAKGNRSKQVTDACKKHGG 507
Query: 496 FYLGSIGGPAALLAMDSIRKVEVLDMEELGMEAVWKIEVENFPAFIVVDDKGNDFFQQL 554
FYLGSIGGPAA+LA DSI++V+ + ELGMEAVWKIEV +FPAFI+VDDKGND F ++
Sbjct: 508 FYLGSIGGPAAILAKDSIKEVKCIAFPELGMEAVWKIEVVDFPAFIIVDDKGNDMFSKM 566
>gi|94469897|gb|ABF20402.1| fumarate hydratase [Leishmania tropica]
Length = 568
Score = 697 bits (1799), Expect = 0.0, Method: Composition-based stats.
Identities = 333/537 (62%), Positives = 416/537 (77%), Gaps = 8/537 (1%)
Query: 19 FVPLLPHLHHKDTEYTLV--TKDYVSVVNPGAGLPEILKVEAAGLTLLASRAIGDVQHFL 76
F P PH H TE+ V ++ YV V ++LKV LT+LA RA DV HF
Sbjct: 35 FQPTDPH--HHQTEFAKVEGSEKYVEEVEVFG--RQVLKVNPEALTILAHRAFSDVHHFF 90
Query: 77 RPSHLASLRSIFEDPEASDNDRFVALQLIKNANIAAARILPGCQDTGTAIIAGYKGEQVF 136
R HL R EDPEASDNDR+VA L+KNA IAA R+LP CQDTGTAI+ G +GE +
Sbjct: 91 RKDHLEGWRRAIEDPEASDNDRYVATTLLKNACIAAGRVLPSCQDTGTAIVLGKRGELCW 150
Query: 137 TNGDDEEALSRGVHHIYTTTNLRYSQNVPLTMYDEKNTGCNLPAQIDLYATKGCEYEFFF 196
T G+DE+ LS+G+ + Y NLRYSQ L M+ E NTG NLPAQ+DL A G +YEF F
Sbjct: 151 TGGEDEKCLSKGIWNAYRYHNLRYSQTAALDMFKECNTGDNLPAQLDLLAVPGSDYEFLF 210
Query: 197 VAKGGGSANKAFLFQETKSVLNPKSLRNFLEEKISTIGTSACPPYHMAVVVGGTSAEMTM 256
+AKGGGSANKA+L+QETK++LNPKSLR F+EEK+ T+GT+ACPPYH+A+V+GGTSAEMTM
Sbjct: 211 IAKGGGSANKAYLYQETKALLNPKSLRAFIEEKLKTLGTAACPPYHIALVIGGTSAEMTM 270
Query: 257 KAVKYASCKYLDELPTKPDESKGYTYRDLEMEQMVMDICRNIGMGAQFGGKYFAHDARVI 316
K VK ASC+Y D LPT D+ G +RD E E++VM++ + G+GAQFGGKYFAH ARVI
Sbjct: 271 KTVKLASCRYYDSLPTTGDKY-GRAFRDPEWEKIVMEVAQKSGIGAQFGGKYFAHQARVI 329
Query: 317 RMPRHGASCPIGIGVSCSADRQALAKINKDGIWVEKLEMDPAKYLPEVTEDQLLKVPPVK 376
R+PRHGASCP+G+ VSCSADRQ LA INK GI++E+LE +PA+YLP++ E L V
Sbjct: 330 RLPRHGASCPVGLAVSCSADRQILAHINKSGIYIEQLEQNPAQYLPDIPEAH-LSTTSVN 388
Query: 377 IDLNMPMDKIRAELSRHPVKTRLSLTGTIIVARDIAHARMREMLENNKPLPDYIKNHPVY 436
+ L P+D++R +LS++PV TR+ L GT+IVARDIAHA+++EM++N +PLP+Y+K P+Y
Sbjct: 389 VXLKRPIDEVRQQLSQYPVGTRVMLNGTLIVARDIAHAKIKEMMDNGEPLPEYMKTSPIY 448
Query: 437 YAGPAKRPEALASGSFGPTTAGRMDPFVDLFQANGGSFVMLAKGNRSKRVTEACKKYGGF 496
YAGPAK PE ASGSFGPTTAGRMD +VDLFQ++GGS++ LAKGNRSK+VT+ACKK+GGF
Sbjct: 449 YAGPAKTPEGYASGSFGPTTAGRMDSYVDLFQSHGGSYITLAKGNRSKQVTDACKKHGGF 508
Query: 497 YLGSIGGPAALLAMDSIRKVEVLDMEELGMEAVWKIEVENFPAFIVVDDKGNDFFQQ 553
YLGSIGGPAA+LA DSI++V L ELGMEAVWKIEVE+FPAFIVVDDKGND + +
Sbjct: 509 YLGSIGGPAAILAKDSIKQVTCLAFPELGMEAVWKIEVEDFPAFIVVDDKGNDMYSK 565
>gi|94469895|gb|ABF20401.1| fumarate hydratase [Leishmania infantum]
Length = 568
Score = 697 bits (1799), Expect = 0.0, Method: Composition-based stats.
Identities = 333/537 (62%), Positives = 419/537 (78%), Gaps = 8/537 (1%)
Query: 19 FVPLLPHLHHKDTEYTLV--TKDYVSVVNPGAGLPEILKVEAAGLTLLASRAIGDVQHFL 76
F P PH H TE+ V ++ YV V ++LKV LT+LA RA DV HF
Sbjct: 35 FQPTDPH--HHQTEFAKVEGSEKYVEEVEVFG--RKVLKVNPEALTILAHRAFSDVHHFF 90
Query: 77 RPSHLASLRSIFEDPEASDNDRFVALQLIKNANIAAARILPGCQDTGTAIIAGYKGEQVF 136
R HL R EDPEASDNDR+VA+ L+KNA IAA R+LP CQDTGTAI+ G +GE +
Sbjct: 91 RKDHLEGWRRAIEDPEASDNDRYVAMTLLKNACIAAGRVLPSCQDTGTAIVLGKRGELCW 150
Query: 137 TNGDDEEALSRGVHHIYTTTNLRYSQNVPLTMYDEKNTGCNLPAQIDLYATKGCEYEFFF 196
T G+DE+ LS+G+ + Y NLRYSQ L M+ E NTG NLPAQ+DL A G +YEF F
Sbjct: 151 TGGEDEKYLSKGIWNAYRYHNLRYSQTAALDMFKECNTGDNLPAQLDLLAVPGSDYEFLF 210
Query: 197 VAKGGGSANKAFLFQETKSVLNPKSLRNFLEEKISTIGTSACPPYHMAVVVGGTSAEMTM 256
+AKGGGSANKA+L+QETK++LNPKSLR F+EEK+ T+GT+ACPPYH+A+V+GGTSAEMTM
Sbjct: 211 IAKGGGSANKAYLYQETKALLNPKSLRAFIEEKLKTLGTAACPPYHIALVIGGTSAEMTM 270
Query: 257 KAVKYASCKYLDELPTKPDESKGYTYRDLEMEQMVMDICRNIGMGAQFGGKYFAHDARVI 316
K VK ASC+Y D LPT D+ G +RD E E++VM++ + G+GAQFGGKYFAH ARVI
Sbjct: 271 KTVKLASCRYYDSLPTTGDKY-GRAFRDPEWEKIVMEVAQKSGIGAQFGGKYFAHQARVI 329
Query: 317 RMPRHGASCPIGIGVSCSADRQALAKINKDGIWVEKLEMDPAKYLPEVTEDQLLKVPPVK 376
R+PRHGASCP+G+ VSCSADRQ LA IN+ GI++E+LE +PA+YLP++ E + L V
Sbjct: 330 RLPRHGASCPVGLAVSCSADRQILAHINQSGIYIEQLEQNPAQYLPDIPEVR-LSTTSVN 388
Query: 377 IDLNMPMDKIRAELSRHPVKTRLSLTGTIIVARDIAHARMREMLENNKPLPDYIKNHPVY 436
+DL P+D++R +LS++PV TR+ L GT+IVARDIAHA+++EM++N +PLP+Y+K P+Y
Sbjct: 389 VDLKRPIDEVRQQLSQYPVGTRVMLNGTLIVARDIAHAKIKEMMDNGEPLPEYMKTSPIY 448
Query: 437 YAGPAKRPEALASGSFGPTTAGRMDPFVDLFQANGGSFVMLAKGNRSKRVTEACKKYGGF 496
YAGPAK PE ASGSFGPTTAGRMD +VDLFQ++GGS++ LAKGNRSK+VT+ACKK+GGF
Sbjct: 449 YAGPAKTPEGHASGSFGPTTAGRMDSYVDLFQSHGGSYITLAKGNRSKQVTDACKKHGGF 508
Query: 497 YLGSIGGPAALLAMDSIRKVEVLDMEELGMEAVWKIEVENFPAFIVVDDKGNDFFQQ 553
YLGSIGGPAA+LA DSI++V L ELGMEAVWKIEVE+FPAFIVVDDKGND + +
Sbjct: 509 YLGSIGGPAAILAKDSIKEVTCLAFPELGMEAVWKIEVEDFPAFIVVDDKGNDMYSK 565
>gi|94469883|gb|ABF20395.1| fumarate hydratase [Leishmania infantum]
Length = 568
Score = 697 bits (1799), Expect = 0.0, Method: Composition-based stats.
Identities = 334/537 (62%), Positives = 419/537 (78%), Gaps = 8/537 (1%)
Query: 19 FVPLLPHLHHKDTEYTLV--TKDYVSVVNPGAGLPEILKVEAAGLTLLASRAIGDVQHFL 76
F P PH H TE+ V ++ YV V ++LKV LT+LA RA DV HF
Sbjct: 35 FQPTDPH--HHQTEFAKVEGSEKYVEEVEVFG--RKVLKVNPEALTILAHRAFSDVHHFF 90
Query: 77 RPSHLASLRSIFEDPEASDNDRFVALQLIKNANIAAARILPGCQDTGTAIIAGYKGEQVF 136
R HL R EDPEASDNDR+VA+ L+KNA IAA R+LP CQDTGTAI+ G +GE +
Sbjct: 91 RKDHLEGWRRAIEDPEASDNDRYVAMTLLKNACIAAGRVLPSCQDTGTAIVLGKRGELCW 150
Query: 137 TNGDDEEALSRGVHHIYTTTNLRYSQNVPLTMYDEKNTGCNLPAQIDLYATKGCEYEFFF 196
T G+DE+ LS+G+ + Y NLRYSQ L M+ E NTG NLPAQ+DL A G +YEF F
Sbjct: 151 TGGEDEKYLSKGIWNAYRYHNLRYSQTAALDMFKECNTGDNLPAQLDLLAVPGSDYEFLF 210
Query: 197 VAKGGGSANKAFLFQETKSVLNPKSLRNFLEEKISTIGTSACPPYHMAVVVGGTSAEMTM 256
+AKGGGSANKA+L+QETK++LNPKSLR F+EEK+ T+GT+ACPPYH+A+V+GGTSAEMTM
Sbjct: 211 IAKGGGSANKAYLYQETKALLNPKSLRAFIEEKLKTLGTAACPPYHIALVIGGTSAEMTM 270
Query: 257 KAVKYASCKYLDELPTKPDESKGYTYRDLEMEQMVMDICRNIGMGAQFGGKYFAHDARVI 316
K VK ASC+Y D LPT D+ G +RD E E++VM++ + G+GAQFGGKYFAH ARVI
Sbjct: 271 KTVKLASCRYYDSLPTTGDKY-GRAFRDPEWEKIVMEVAQKSGIGAQFGGKYFAHQARVI 329
Query: 317 RMPRHGASCPIGIGVSCSADRQALAKINKDGIWVEKLEMDPAKYLPEVTEDQLLKVPPVK 376
R+PRHGASCP+G+ VSCSADRQ LA INK GI++E+LE +PA+YLP++ E + L V
Sbjct: 330 RLPRHGASCPVGLAVSCSADRQILAHINKSGIYIEQLEQNPAQYLPDIPEVR-LSTTSVN 388
Query: 377 IDLNMPMDKIRAELSRHPVKTRLSLTGTIIVARDIAHARMREMLENNKPLPDYIKNHPVY 436
+DL P+D++R +LS++PV TR+ L GT+IVARDIAHA+++EM++N +PLP+Y+K P+Y
Sbjct: 389 VDLKRPIDEVRQQLSQYPVGTRVMLNGTLIVARDIAHAKIKEMMDNGEPLPEYMKMSPIY 448
Query: 437 YAGPAKRPEALASGSFGPTTAGRMDPFVDLFQANGGSFVMLAKGNRSKRVTEACKKYGGF 496
YAGPAK PE ASGSFGPTTAGRMD +VDLFQ++GGS++ LAKGNRSK+VT+ACKK+GGF
Sbjct: 449 YAGPAKTPEGHASGSFGPTTAGRMDSYVDLFQSHGGSYITLAKGNRSKQVTDACKKHGGF 508
Query: 497 YLGSIGGPAALLAMDSIRKVEVLDMEELGMEAVWKIEVENFPAFIVVDDKGNDFFQQ 553
YLGSIGGPAA+LA DSI++V L ELGMEAVWKIEVE+FPAFIVVDDKGND + +
Sbjct: 509 YLGSIGGPAAILAKDSIKEVTCLAFPELGMEAVWKIEVEDFPAFIVVDDKGNDMYSK 565