BLASTP 2.2.17 [Aug-26-2007]
Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Reference for composition-based statistics:
Schäffer, Alejandro A., L. Aravind, Thomas L. Madden,
Schaffer, Alejandro A., L. Aravind, Thomas L. Madden,
Sergei Shavirin, John L. Spouge, Yuri I. Wolf,
Eugene V. Koonin, and Stephen F. Altschul (2001),
"Improving the accuracy of PSI-BLAST protein database searches with
composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005.
Query= ENSG00000110921__[Homo_sapiens]
(396 letters)
Database: nr.pal
6,348,806 sequences; 2,166,943,470 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|450346|emb|CAA53059.1| unnamed protein product [Hepatiti... 768 0.0
gi|4557769|ref|NP_000422.1| mevalonate kinase [Homo sapiens... 762 0.0
gi|33303805|gb|AAQ02416.1| mevalonate kinase [synthetic con... 761 0.0
gi|62089024|dbj|BAD92959.1| mevalonate kinase variant [Homo... 761 0.0
gi|109098668|ref|XP_001105759.1| PREDICTED: mevalonate kina... 725 0.0
gi|73995337|ref|XP_543435.2| PREDICTED: similar to Mevalona... 639 0.0
gi|62751666|ref|NP_001015528.1| mevalonate kinase [Bos taur... 632 e-179
gi|59857699|gb|AAX08684.1| mevalonate kinase [Bos taurus] 631 e-179
gi|109098672|ref|XP_001105689.1| PREDICTED: mevalonate kina... 607 e-172
gi|61555432|gb|AAX46713.1| mevalonate kinase [Bos taurus] 603 e-171
gi|13592007|ref|NP_112325.1| mevalonate kinase [Rattus norv... 598 e-169
gi|12963731|ref|NP_076045.1| mevalonate kinase [Mus musculu... 583 e-165
gi|74203980|dbj|BAE28997.1| unnamed protein product [Mus mu... 575 e-162
gi|126324791|ref|XP_001364115.1| PREDICTED: similar to meva... 551 e-155
gi|82898655|ref|XP_918559.1| PREDICTED: similar to mevalona... 514 e-144
gi|123227559|emb|CAM15186.1| novel protein similar to verte... 419 e-115
gi|55925207|ref|NP_001007350.1| hypothetical protein LOC492... 418 e-115
gi|61555394|gb|AAX46707.1| mevalonate kinase [Bos taurus] 416 e-114
gi|47226511|emb|CAG08527.1| unnamed protein product [Tetrao... 401 e-110
gi|119618276|gb|EAW97870.1| mevalonate kinase (mevalonic ac... 378 e-103
gi|72125755|ref|XP_790690.1| PREDICTED: similar to Mevalona... 311 4e-83
gi|148687960|gb|EDL19907.1| mevalonate kinase, isoform CRA_... 266 2e-69
gi|149063615|gb|EDM13938.1| mevalonate kinase, isoform CRA_... 258 4e-67
gi|149063616|gb|EDM13939.1| mevalonate kinase, isoform CRA_... 256 2e-66
gi|58260882|ref|XP_567851.1| cystathionine beta-lyase [Cryp... 227 1e-57
gi|58260880|ref|XP_567850.1| cystathionine beta-lyase [Cryp... 227 1e-57
gi|5578718|gb|AAD45421.1|L77688_1 mevalonate kinase [Arabid... 219 2e-55
gi|118098609|ref|XP_001231562.1| PREDICTED: hypothetical pr... 218 4e-55
gi|16417946|gb|AAL18925.1|AF429384_1 mevalonate kinase [Hev... 218 4e-55
gi|15240936|ref|NP_198097.1| MK/MVK; mevalonate kinase [Ara... 215 4e-54
gi|66824057|ref|XP_645383.1| hypothetical protein DDBDRAFT_... 213 2e-53
gi|149246950|ref|XP_001527900.1| hypothetical protein LELG_... 211 8e-53
gi|68464835|ref|XP_723495.1| mevalonate kinase [Candida alb... 209 4e-52
gi|119618277|gb|EAW97871.1| mevalonate kinase (mevalonic ac... 208 7e-52
gi|87240539|gb|ABD32397.1| Mevalonate and galactokinase [Me... 206 2e-51
gi|115481534|ref|NP_001064360.1| Os10g0329300 [Oryza sativa... 201 6e-50
gi|50424525|ref|XP_460851.1| hypothetical protein DEHA0F121... 201 7e-50
gi|71993800|ref|NP_001022868.1| Y42G9A.4c [Caenorhabditis e... 199 4e-49
gi|71993806|ref|NP_001022869.1| Y42G9A.4d [Caenorhabditis e... 197 8e-49
gi|71993795|ref|NP_001022867.1| Y42G9A.4b [Caenorhabditis e... 196 3e-48
gi|19113749|ref|NP_592837.1| mevalonate kinase Erg12 (predi... 189 2e-46
gi|16905216|gb|AAL31086.1|AC091749_15 putative mevalonate k... 188 5e-46
gi|85102580|ref|XP_961360.1| hypothetical protein NCU03633 ... 186 2e-45
gi|91084321|ref|XP_972334.1| PREDICTED: similar to mevalona... 184 7e-45
gi|169859430|ref|XP_001836355.1| hypothetical protein CC1G_... 181 6e-44
gi|116206428|ref|XP_001229023.1| hypothetical protein CHGG_... 181 6e-44
gi|121706910|ref|XP_001271672.1| mevalonate kinase [Aspergi... 179 3e-43
gi|115398019|ref|XP_001214601.1| conserved hypothetical pro... 179 3e-43
gi|67526823|ref|XP_661473.1| hypothetical protein AN3869.2 ... 176 3e-42
gi|70994538|ref|XP_752047.1| mevalonate kinase [Aspergillus... 176 3e-42
gi|119500972|ref|XP_001267243.1| mevalonate kinase [Neosart... 174 8e-42
gi|47200914|emb|CAF88123.1| unnamed protein product [Tetrao... 174 8e-42
gi|125574393|gb|EAZ15677.1| hypothetical protein OsJ_029886... 174 1e-41
gi|169773659|ref|XP_001821298.1| [Aspergillus oryzae] >gi|8... 172 3e-41
gi|125531485|gb|EAY78050.1| hypothetical protein OsI_032009... 172 4e-41
gi|146414678|ref|XP_001483309.1| hypothetical protein PGUG_... 171 7e-41
gi|6323864|ref|NP_013935.1| Mevalonate kinase, acts in the ... 171 1e-40
gi|50305147|ref|XP_452532.1| unnamed protein product [Kluyv... 171 1e-40
gi|50546973|ref|XP_500956.1| hypothetical protein [Yarrowia... 169 3e-40
gi|71022827|ref|XP_761643.1| hypothetical protein UM05496.1... 168 5e-40
gi|45190937|ref|NP_985191.1| AER335Wp [Ashbya gossypii ATCC... 167 1e-39
gi|110748754|ref|XP_624545.2| PREDICTED: similar to Mevalon... 164 1e-38
gi|50287417|ref|XP_446138.1| unnamed protein product [Candi... 164 1e-38
gi|145257009|ref|XP_001401587.1| hypothetical protein An04g... 164 2e-38
gi|46123069|ref|XP_386088.1| hypothetical protein FG05912.1... 163 2e-38
gi|153792072|ref|NP_001093299.1| mevalonate kinase [Bombyx ... 163 3e-38
gi|119181177|ref|XP_001241830.1| hypothetical protein CIMG_... 162 4e-38
gi|39978123|ref|XP_370449.1| hypothetical protein MGG_06946... 160 1e-37
gi|157113429|ref|XP_001657825.1| mevalonate kinase [Aedes a... 159 2e-37
gi|125560302|gb|EAZ05750.1| hypothetical protein OsI_026982... 159 3e-37
gi|147801314|emb|CAN77024.1| hypothetical protein [Vitis vi... 158 7e-37
gi|72041321|ref|XP_793882.1| PREDICTED: similar to mevalona... 153 3e-35
gi|78707210|ref|NP_001027412.1| CG33671 CG33671-PA [Drosoph... 148 7e-34
gi|9049522|gb|AAF82406.1| truncated mevalonate kinase [Homo... 144 1e-32
gi|108947727|gb|ABG24208.1| mevalonate kinase [Arnebia euch... 126 3e-27
gi|2804172|dbj|BAA24409.1| mevalonate kinase [Saccharomyces... 121 8e-26
gi|71993790|ref|NP_001022866.1| Y42G9A.4a [Caenorhabditis e... 120 1e-25
gi|157776698|ref|XP_001666415.1| hypothetical protein CBG21... 117 2e-24
gi|119719800|ref|YP_920295.1| mevalonate kinase [Thermofilu... 114 9e-24
gi|14520757|ref|NP_126232.1| mevalonate kinase [Pyrococcus ... 109 4e-22
gi|14591399|ref|NP_143478.1| mevalonate kinase [Pyrococcus ... 106 2e-21
gi|57641409|ref|YP_183887.1| mevalonate kinase [Thermococcu... 97 2e-18
gi|18978009|ref|NP_579366.1| mevalonate kinase [Pyrococcus ... 97 2e-18
gi|124027753|ref|YP_001013073.1| Mevalonate kinase [Hyperth... 92 7e-17
gi|123490584|ref|XP_001325649.1| mevalonate kinase family p... 90 3e-16
gi|116753789|ref|YP_842907.1| mevalonate kinase [Methanosae... 88 1e-15
gi|91774304|ref|YP_566996.1| mevalonate kinase [Methanococc... 87 2e-15
gi|21227864|ref|NP_633786.1| mevalonate kinase [Methanosarc... 85 8e-15
gi|126465130|ref|YP_001040239.1| mevalonate kinase [Staphyl... 85 9e-15
gi|110668819|ref|YP_658630.1| mevalonate kinase [Haloquadra... 84 2e-14
gi|84489658|ref|YP_447890.1| putative mevalonate kinase [Me... 82 8e-14
gi|55377012|ref|YP_134862.1| mevalonate kinase [Haloarcula ... 81 2e-13
gi|20089491|ref|NP_615566.1| mevalonate kinase [Methanosarc... 79 7e-13
gi|159900828|ref|YP_001547075.1| mevalonate kinase [Herpeto... 78 9e-13
gi|73668945|ref|YP_304960.1| mevalonate kinase [Methanosarc... 77 2e-12
gi|47197810|emb|CAF89434.1| unnamed protein product [Tetrao... 76 4e-12
gi|2497518|sp|Q50559|KIME_METTH Mevalonate kinase (MK) >gi|... 76 5e-12
gi|147921498|ref|YP_684687.1| mevalonate kinase [uncultured... 75 7e-12
gi|148656261|ref|YP_001276466.1| mevalonate kinase [Roseifl... 75 8e-12
gi|15678075|ref|NP_275189.1| mevalonate kinase [Methanother... 74 2e-11
>gi|450346|emb|CAA53059.1| unnamed protein product [Hepatitis B virus]
Length = 557
Score = 768 bits (1984), Expect = 0.0, Method: Composition-based stats.
Identities = 388/396 (97%), Positives = 388/396 (97%)
Query: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 60
MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR
Sbjct: 162 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 221
Query: 61 AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC 120
AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC
Sbjct: 222 AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC 281
Query: 121 RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE 180
RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE
Sbjct: 282 RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE 341
Query: 181 DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP 240
DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP
Sbjct: 342 DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP 401
Query: 241 RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM 300
RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM
Sbjct: 402 RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM 461
Query: 301 NQHHLNALGVGHASLDQLCQVTRARGLHSKLTXXXXXXXXITLLKPGLEQPEVEATKQAL 360
NQHHLNALGVGHASLDQLCQVTRARGLHSKLT ITLLKPGLEQPEVEATKQAL
Sbjct: 462 NQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL 521
Query: 361 TSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL 396
TSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL
Sbjct: 522 TSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL 557
>gi|4557769|ref|NP_000422.1| mevalonate kinase [Homo sapiens]
gi|167001643|ref|NP_001107657.1| mevalonate kinase [Homo sapiens]
gi|417215|sp|Q03426|KIME_HUMAN Mevalonate kinase (MK)
gi|187561|gb|AAB59362.1| mevalonate kinase
gi|450347|emb|CAA53060.1| unnamed protein product [Homo sapiens]
gi|9049533|gb|AAF82407.1| mevalonate kinase [Homo sapiens]
gi|16359371|gb|AAH16140.1| MVK protein [Homo sapiens]
gi|119618278|gb|EAW97872.1| mevalonate kinase (mevalonic aciduria), isoform CRA_c [Homo
sapiens]
gi|119618279|gb|EAW97873.1| mevalonate kinase (mevalonic aciduria), isoform CRA_c [Homo
sapiens]
gi|123980372|gb|ABM82015.1| mevalonate kinase (mevalonic aciduria) [synthetic construct]
gi|123995191|gb|ABM85197.1| mevalonate kinase (mevalonic aciduria) [synthetic construct]
Length = 396
Score = 762 bits (1967), Expect = 0.0, Method: Composition-based stats.
Identities = 388/396 (97%), Positives = 388/396 (97%)
Query: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 60
MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR
Sbjct: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 60
Query: 61 AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC 120
AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC
Sbjct: 61 AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC 120
Query: 121 RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE 180
RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE
Sbjct: 121 RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE 180
Query: 181 DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP 240
DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP
Sbjct: 181 DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP 240
Query: 241 RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM 300
RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM
Sbjct: 241 RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM 300
Query: 301 NQHHLNALGVGHASLDQLCQVTRARGLHSKLTXXXXXXXXITLLKPGLEQPEVEATKQAL 360
NQHHLNALGVGHASLDQLCQVTRARGLHSKLT ITLLKPGLEQPEVEATKQAL
Sbjct: 301 NQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL 360
Query: 361 TSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL 396
TSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL
Sbjct: 361 TSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL 396
>gi|33303805|gb|AAQ02416.1| mevalonate kinase [synthetic construct]
Length = 397
Score = 761 bits (1966), Expect = 0.0, Method: Composition-based stats.
Identities = 388/396 (97%), Positives = 388/396 (97%)
Query: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 60
MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR
Sbjct: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 60
Query: 61 AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC 120
AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC
Sbjct: 61 AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC 120
Query: 121 RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE 180
RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE
Sbjct: 121 RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE 180
Query: 181 DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP 240
DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP
Sbjct: 181 DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP 240
Query: 241 RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM 300
RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM
Sbjct: 241 RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM 300
Query: 301 NQHHLNALGVGHASLDQLCQVTRARGLHSKLTXXXXXXXXITLLKPGLEQPEVEATKQAL 360
NQHHLNALGVGHASLDQLCQVTRARGLHSKLT ITLLKPGLEQPEVEATKQAL
Sbjct: 301 NQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL 360
Query: 361 TSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL 396
TSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL
Sbjct: 361 TSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL 396
>gi|62089024|dbj|BAD92959.1| mevalonate kinase variant [Homo sapiens]
Length = 421
Score = 761 bits (1965), Expect = 0.0, Method: Composition-based stats.
Identities = 387/396 (97%), Positives = 388/396 (97%)
Query: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 60
MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDL+LPNIGIKR
Sbjct: 26 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLNLPNIGIKR 85
Query: 61 AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC 120
AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC
Sbjct: 86 AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC 145
Query: 121 RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE 180
RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE
Sbjct: 146 RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE 205
Query: 181 DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP 240
DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP
Sbjct: 206 DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP 265
Query: 241 RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM 300
RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM
Sbjct: 266 RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM 325
Query: 301 NQHHLNALGVGHASLDQLCQVTRARGLHSKLTXXXXXXXXITLLKPGLEQPEVEATKQAL 360
NQHHLNALGVGHASLDQLCQVTRARGLHSKLT ITLLKPGLEQPEVEATKQAL
Sbjct: 326 NQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL 385
Query: 361 TSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL 396
TSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL
Sbjct: 386 TSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL 421
>gi|109098668|ref|XP_001105759.1| PREDICTED: mevalonate kinase isoform 2 [Macaca mulatta]
gi|109098670|ref|XP_001105815.1| PREDICTED: mevalonate kinase isoform 3 [Macaca mulatta]
Length = 396
Score = 725 bits (1872), Expect = 0.0, Method: Composition-based stats.
Identities = 373/396 (94%), Positives = 375/396 (94%)
Query: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 60
MLSEVLLVSAPGKVILHGEHAVVHGKVALAV+LNLRTFLRLQPHSNGKVDLSLPNIGIK
Sbjct: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVALNLRTFLRLQPHSNGKVDLSLPNIGIKW 60
Query: 61 AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC 120
AWDVARLQ LDTSFLEQGD TTPT E VEKLKEVAGLPDDCAVTE LAVLAFLYLYLSIC
Sbjct: 61 AWDVARLQLLDTSFLEQGDATTPTPELVEKLKEVAGLPDDCAVTESLAVLAFLYLYLSIC 120
Query: 121 RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE 180
RKQRALPSLDIVVWSELP GAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGD VNRWTKE
Sbjct: 121 RKQRALPSLDIVVWSELPHGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDRVNRWTKE 180
Query: 181 DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP 240
DLELINKWAFQGER+IHGNPSGVDNAVSTWGGALRY QGKISSLKR PALQILLTNTKVP
Sbjct: 181 DLELINKWAFQGERVIHGNPSGVDNAVSTWGGALRYQQGKISSLKRPPALQILLTNTKVP 240
Query: 241 RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM 300
RNTR LVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM
Sbjct: 241 RNTRTLVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM 300
Query: 301 NQHHLNALGVGHASLDQLCQVTRARGLHSKLTXXXXXXXXITLLKPGLEQPEVEATKQAL 360
NQHHLNALGVGHASLDQLCQVTRA GLHSKLT ITLLKPGLEQPEVEATKQAL
Sbjct: 301 NQHHLNALGVGHASLDQLCQVTRAHGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL 360
Query: 361 TSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL 396
TSCGFDC ETSIGAPGVSIHSATSLDSRVQQALDGL
Sbjct: 361 TSCGFDCWETSIGAPGVSIHSATSLDSRVQQALDGL 396
>gi|73995337|ref|XP_543435.2| PREDICTED: similar to Mevalonate kinase (MK) [Canis familiaris]
Length = 409
Score = 639 bits (1648), Expect = 0.0, Method: Composition-based stats.
Identities = 327/400 (81%), Positives = 350/400 (87%), Gaps = 4/400 (1%)
Query: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 60
MLSEVLLVSAPGKVILHGEHAVVHGK+ALAV+LNLRTFLRLQPHSNGK+ L+LPNIG+KR
Sbjct: 10 MLSEVLLVSAPGKVILHGEHAVVHGKIALAVALNLRTFLRLQPHSNGKMCLNLPNIGVKR 69
Query: 61 AWDVARLQSLDTSFLE----QGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLY 116
AWDVARLQ DTSFLE GD PTSEQVEKLKEVAG+P D A E LAVLAFLYLY
Sbjct: 70 AWDVARLQLQDTSFLEPGNATGDAAAPTSEQVEKLKEVAGIPKDGADPECLAVLAFLYLY 129
Query: 117 LSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNR 176
LSICRKQR LPSLDI VWSELP GAGLGSSAAYSVCLAAALLT CE IPNP +G+ +R
Sbjct: 130 LSICRKQRTLPSLDITVWSELPTGAGLGSSAAYSVCLAAALLTACEAIPNPQNNGESASR 189
Query: 177 WTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTN 236
WT EDLELINKWAFQGERMIHGNPSGVDN +STWGGALRY QGKISS+KR PAL+ILLTN
Sbjct: 190 WTMEDLELINKWAFQGERMIHGNPSGVDNTISTWGGALRYQQGKISSIKRLPALKILLTN 249
Query: 237 TKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEE 296
TKVPR+T+ALVA VR+RLLKFPEIVAPLLTSI+AISLECER L EM APAPE YLVLEE
Sbjct: 250 TKVPRSTKALVASVRSRLLKFPEIVAPLLTSINAISLECERTLEEMASAPAPEHYLVLEE 309
Query: 297 LIDMNQHHLNALGVGHASLDQLCQVTRARGLHSKLTXXXXXXXXITLLKPGLEQPEVEAT 356
LID+NQHHLNALGVGHASLDQLCQVT A GLHSKLT ITLL+P LEQP+VEA
Sbjct: 310 LIDINQHHLNALGVGHASLDQLCQVTMAHGLHSKLTGAGGGGCGITLLRPDLEQPKVEAM 369
Query: 357 KQALTSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL 396
KQALTSCGFDC ET IGAPG+SIHSA SLD++VQ+ALDGL
Sbjct: 370 KQALTSCGFDCWETRIGAPGISIHSAASLDTQVQRALDGL 409
>gi|62751666|ref|NP_001015528.1| mevalonate kinase [Bos taurus]
gi|75060948|sp|Q5E9T8|KIME_BOVIN Mevalonate kinase (MK)
gi|59858029|gb|AAX08849.1| mevalonate kinase [Bos taurus]
gi|74356342|gb|AAI04541.1| Mevalonate kinase (mevalonic aciduria) [Bos taurus]
Length = 396
Score = 632 bits (1631), Expect = e-179, Method: Composition-based stats.
Identities = 319/396 (80%), Positives = 344/396 (86%)
Query: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 60
MLSEVLLVSAPGKVILHGEHAVVHGKVALAV+LNLRTFLRLQPHSNG+V L+LPNIG++R
Sbjct: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVALNLRTFLRLQPHSNGRVGLNLPNIGVRR 60
Query: 61 AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC 120
AWDVA LQ LDTSFL GD T++ VEKLKEVAG P DC E LAVLAFLYLYLSIC
Sbjct: 61 AWDVASLQLLDTSFLGHGDSAALTAKHVEKLKEVAGFPKDCVDPEHLAVLAFLYLYLSIC 120
Query: 121 RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE 180
+ QRALPSLDI VWSELP GAGLGSSAAYSVCLAAALLT CEEIPNPLKDG+ RWT+E
Sbjct: 121 QSQRALPSLDITVWSELPTGAGLGSSAAYSVCLAAALLTACEEIPNPLKDGEAAGRWTEE 180
Query: 181 DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP 240
+LELINKWAFQGER+IHGNPSGVDNAVSTWGGALRY QGKISSLKR P L+ILL NTKVP
Sbjct: 181 NLELINKWAFQGERVIHGNPSGVDNAVSTWGGALRYQQGKISSLKRPPVLKILLINTKVP 240
Query: 241 RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM 300
R+T+ LVA VR+RLLKFPEIVAPLLTSIDAISLECERVLGEM AP PE YL LEELIDM
Sbjct: 241 RSTKVLVANVRSRLLKFPEIVAPLLTSIDAISLECERVLGEMAAAPTPEHYLTLEELIDM 300
Query: 301 NQHHLNALGVGHASLDQLCQVTRARGLHSKLTXXXXXXXXITLLKPGLEQPEVEATKQAL 360
NQHHLNALGVGHASLDQLCQVT A GLHSKLT ITLL+P +E+P VEATK+AL
Sbjct: 301 NQHHLNALGVGHASLDQLCQVTTAHGLHSKLTGAGGGGCGITLLRPDVERPAVEATKRAL 360
Query: 361 TSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL 396
+ CGFDC ETS+GAPGVS+H+A SLD+ VQQ LD L
Sbjct: 361 SGCGFDCWETSVGAPGVSVHTAASLDASVQQGLDSL 396
>gi|59857699|gb|AAX08684.1| mevalonate kinase [Bos taurus]
Length = 396
Score = 631 bits (1628), Expect = e-179, Method: Composition-based stats.
Identities = 318/396 (80%), Positives = 343/396 (86%)
Query: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 60
MLSEVLLVSAPGKVILHGEHAVVHGKVALAV+LNLRTFLRLQPHSNG+V L+LPNIG++R
Sbjct: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVALNLRTFLRLQPHSNGRVGLNLPNIGVRR 60
Query: 61 AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC 120
AWDVA LQ LDTSFL GD T++ VEKLKEVAG P DC E LAVLAFLYLYLSIC
Sbjct: 61 AWDVASLQLLDTSFLGHGDSAALTAKHVEKLKEVAGFPKDCVDPEHLAVLAFLYLYLSIC 120
Query: 121 RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE 180
+ QR LPSLDI VWSELP GAGLGSSAAYSVCLAAALLT CEEIPNPLKDG+ RWT+E
Sbjct: 121 QSQRVLPSLDITVWSELPTGAGLGSSAAYSVCLAAALLTACEEIPNPLKDGEAAGRWTEE 180
Query: 181 DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP 240
+LELINKWAFQGER+IHGNPSGVDNAVSTWGGALRY QGKISSLKR P L+ILL NTKVP
Sbjct: 181 NLELINKWAFQGERVIHGNPSGVDNAVSTWGGALRYQQGKISSLKRPPVLKILLINTKVP 240
Query: 241 RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM 300
R+T+ LVA VR+RLLKFPEIVAPLLTSIDAISLECERVLGEM AP PE YL LEELIDM
Sbjct: 241 RSTKVLVANVRSRLLKFPEIVAPLLTSIDAISLECERVLGEMAAAPTPEHYLTLEELIDM 300
Query: 301 NQHHLNALGVGHASLDQLCQVTRARGLHSKLTXXXXXXXXITLLKPGLEQPEVEATKQAL 360
NQHHLNALGVGHASLDQLCQVT A GLHSKLT ITLL+P +E+P VEATK+AL
Sbjct: 301 NQHHLNALGVGHASLDQLCQVTTAHGLHSKLTGAGGGGCGITLLRPDVERPAVEATKRAL 360
Query: 361 TSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL 396
+ CGFDC ETS+GAPGVS+H+A SLD+ VQQ LD L
Sbjct: 361 SGCGFDCWETSVGAPGVSVHTAASLDASVQQGLDSL 396
>gi|109098672|ref|XP_001105689.1| PREDICTED: mevalonate kinase isoform 1 [Macaca mulatta]
Length = 344
Score = 607 bits (1565), Expect = e-172, Method: Composition-based stats.
Identities = 323/396 (81%), Positives = 325/396 (82%), Gaps = 52/396 (13%)
Query: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 60
MLSEVLLVSAPGKVILHGEHAVVHGKVALAV+LNLRTFLRLQPHSNGKVDLSLPNIGIK
Sbjct: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVALNLRTFLRLQPHSNGKVDLSLPNIGIKW 60
Query: 61 AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC 120
AWDVARLQ LDTSFLEQGD TTPT E VEKLKEVAGLPDDCAVTE LAVLAFLYLYLSIC
Sbjct: 61 AWDVARLQLLDTSFLEQGDATTPTPELVEKLKEVAGLPDDCAVTESLAVLAFLYLYLSIC 120
Query: 121 RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE 180
RKQ RWTKE
Sbjct: 121 RKQ----------------------------------------------------RWTKE 128
Query: 181 DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP 240
DLELINKWAFQGER+IHGNPSGVDNAVSTWGGALRY QGKISSLKR PALQILLTNTKVP
Sbjct: 129 DLELINKWAFQGERVIHGNPSGVDNAVSTWGGALRYQQGKISSLKRPPALQILLTNTKVP 188
Query: 241 RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM 300
RNTR LVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM
Sbjct: 189 RNTRTLVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM 248
Query: 301 NQHHLNALGVGHASLDQLCQVTRARGLHSKLTXXXXXXXXITLLKPGLEQPEVEATKQAL 360
NQHHLNALGVGHASLDQLCQVTRA GLHSKLT ITLLKPGLEQPEVEATKQAL
Sbjct: 249 NQHHLNALGVGHASLDQLCQVTRAHGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL 308
Query: 361 TSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL 396
TSCGFDC ETSIGAPGVSIHSATSLDSRVQQALDGL
Sbjct: 309 TSCGFDCWETSIGAPGVSIHSATSLDSRVQQALDGL 344
>gi|61555432|gb|AAX46713.1| mevalonate kinase [Bos taurus]
Length = 440
Score = 603 bits (1555), Expect = e-171, Method: Composition-based stats.
Identities = 306/379 (80%), Positives = 330/379 (87%)
Query: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 60
MLSE LLVSAPGKVILHGEHAVVHGKVALA++LNLRTFLRLQPHSNG+V L+LPNIG++R
Sbjct: 1 MLSEALLVSAPGKVILHGEHAVVHGKVALAMALNLRTFLRLQPHSNGRVGLNLPNIGVRR 60
Query: 61 AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC 120
AWDVA LQ LDTSFL GD T++ VEKLKEVAG P DC E LAVLAFLYLYLSIC
Sbjct: 61 AWDVASLQLLDTSFLGHGDSAALTAKHVEKLKEVAGFPKDCVDPEHLAVLAFLYLYLSIC 120
Query: 121 RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE 180
+ QRALPSLDI VWSELP GAGLGSSAAYSVCLAAALLT CEEIPNPLKDG+ RWT+E
Sbjct: 121 QSQRALPSLDITVWSELPTGAGLGSSAAYSVCLAAALLTACEEIPNPLKDGEAAGRWTEE 180
Query: 181 DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP 240
+LELINKWAFQGER+IHGNPSGVDNAVSTWGGALRY QGKISSLKR P L+ILL NTKVP
Sbjct: 181 NLELINKWAFQGERVIHGNPSGVDNAVSTWGGALRYQQGKISSLKRPPVLKILLINTKVP 240
Query: 241 RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM 300
R+T+ LVA VR+RLLKFPEIVAPLLTSIDAISLECERVLGEM AP PE YL LEELIDM
Sbjct: 241 RSTKVLVANVRSRLLKFPEIVAPLLTSIDAISLECERVLGEMAAAPTPEHYLTLEELIDM 300
Query: 301 NQHHLNALGVGHASLDQLCQVTRARGLHSKLTXXXXXXXXITLLKPGLEQPEVEATKQAL 360
NQHHLNALGVGHASLDQLCQVT A GLHSKLT ITLL+P +E+PEVEATK+AL
Sbjct: 301 NQHHLNALGVGHASLDQLCQVTTAHGLHSKLTGAGGGGCGITLLRPDVERPEVEATKRAL 360
Query: 361 TSCGFDCLETSIGAPGVSI 379
+ GFDC ETS+GAPGVS+
Sbjct: 361 SGYGFDCWETSVGAPGVSV 379
>gi|13592007|ref|NP_112325.1| mevalonate kinase [Rattus norvegicus]
gi|125406|sp|P17256|KIME_RAT Mevalonate kinase (MK)
gi|20151083|pdb|1KVK|A Chain A, The Structure Of Binary Complex Between A Mammalian
Mevalonate Kinase And Atp: Insights Into The Reaction
Mechanism And Human Inherited Disease
gi|205378|gb|AAA41588.1| mevalonate kinase (EC 2.7.1.36)
gi|149063614|gb|EDM13937.1| mevalonate kinase, isoform CRA_a [Rattus norvegicus]
Length = 395
Score = 598 bits (1541), Expect = e-169, Method: Composition-based stats.
Identities = 314/393 (79%), Positives = 347/393 (88%)
Query: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 60
MLSEVLLVSAPGKVILHGEHAVVHGKVALAV+LNLRTFL L+P SNGKV L+LPN+GIK+
Sbjct: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVALNLRTFLVLRPQSNGKVSLNLPNVGIKQ 60
Query: 61 AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC 120
WDVA LQ LDT FLEQGDV PT EQ+EKLK+VAGLP DC E L++LAFLYLYL+IC
Sbjct: 61 VWDVATLQLLDTGFLEQGDVPAPTLEQLEKLKKVAGLPRDCVGNEGLSLLAFLYLYLAIC 120
Query: 121 RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE 180
RKQR LPSLDI+VWSELPPGAGLGSSAAYSVC+AAALLT CEE+ NPLKD + W +E
Sbjct: 121 RKQRTLPSLDIMVWSELPPGAGLGSSAAYSVCVAAALLTACEEVTNPLKDRGSIGSWPEE 180
Query: 181 DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP 240
DL+ INKWA++GER+IHGNPSGVDN+VSTWGGALRY QGK+SSLKR PALQILLTNTKVP
Sbjct: 181 DLKSINKWAYEGERVIHGNPSGVDNSVSTWGGALRYQQGKMSSLKRLPALQILLTNTKVP 240
Query: 241 RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM 300
R+T+ALVAGVR+RL+KFPEI+APLLTSIDAISLECERVLGEM AP PEQYLVLEEL+DM
Sbjct: 241 RSTKALVAGVRSRLIKFPEIMAPLLTSIDAISLECERVLGEMAAAPVPEQYLVLEELMDM 300
Query: 301 NQHHLNALGVGHASLDQLCQVTRARGLHSKLTXXXXXXXXITLLKPGLEQPEVEATKQAL 360
NQHHLNALGVGHASLDQLCQVT A GLHSKLT ITLLKPGLE+ +VEA KQAL
Sbjct: 301 NQHHLNALGVGHASLDQLCQVTAAHGLHSKLTGAGGGGCGITLLKPGLERAKVEAAKQAL 360
Query: 361 TSCGFDCLETSIGAPGVSIHSATSLDSRVQQAL 393
T CGFDC ETSIGAPGVS+HSATS++ V+QAL
Sbjct: 361 TGCGFDCWETSIGAPGVSMHSATSIEDPVRQAL 393
>gi|12963731|ref|NP_076045.1| mevalonate kinase [Mus musculus]
gi|8928154|sp|Q9R008|KIME_MOUSE Mevalonate kinase (MK)
gi|6006984|gb|AAF00700.1|AF137598_1 mevalonate kinase [Mus musculus]
gi|13542811|gb|AAH05606.1| Mevalonate kinase [Mus musculus]
Length = 395
Score = 583 bits (1503), Expect = e-165, Method: Composition-based stats.
Identities = 311/393 (79%), Positives = 339/393 (86%)
Query: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 60
MLSE LLVSAPGKVILHGEHAVVHGKVALA +LNLRTFL L+P SNGKV ++LPNIGIK+
Sbjct: 1 MLSEALLVSAPGKVILHGEHAVVHGKVALAAALNLRTFLLLRPQSNGKVSVNLPNIGIKQ 60
Query: 61 AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC 120
WDV LQ LDTSFLEQGDV+ PT EQ+EKLK++ LP D A E +A+LAFLYLYL+IC
Sbjct: 61 VWDVGMLQRLDTSFLEQGDVSVPTLEQLEKLKKMGDLPRDRAGNEGMALLAFLYLYLAIC 120
Query: 121 RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE 180
RKQR LPSLD+VVWSELPPGAGLGSSAAYSVCLAAALLT CEE+ NPLKDG V+RW +E
Sbjct: 121 RKQRTLPSLDMVVWSELPPGAGLGSSAAYSVCLAAALLTACEEVSNPLKDGVSVSRWPEE 180
Query: 181 DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP 240
DL+ INKWAF+GER+IHGNPSGVDNAVSTWGGALR+ QG +SSLK P+LQILLTNTKVP
Sbjct: 181 DLKSINKWAFEGERVIHGNPSGVDNAVSTWGGALRFQQGTMSSLKSLPSLQILLTNTKVP 240
Query: 241 RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM 300
R+T+ALVA VR+RL KFPEIVAPLLTSIDAISLECERVLGEM AP PEQYLVLEELIDM
Sbjct: 241 RSTKALVAAVRSRLTKFPEIVAPLLTSIDAISLECERVLGEMVAAPVPEQYLVLEELIDM 300
Query: 301 NQHHLNALGVGHASLDQLCQVTRARGLHSKLTXXXXXXXXITLLKPGLEQPEVEATKQAL 360
NQHHLNALGVGH SLDQLCQVT A GLHSKLT ITLLKPGLEQ VEA KQAL
Sbjct: 301 NQHHLNALGVGHNSLDQLCQVTAAHGLHSKLTGAGGGGCGITLLKPGLEQATVEAAKQAL 360
Query: 361 TSCGFDCLETSIGAPGVSIHSATSLDSRVQQAL 393
TSCGFDC ETSIGAPGVS HSA ++ V+QAL
Sbjct: 361 TSCGFDCWETSIGAPGVSTHSAAAVGDPVRQAL 393
>gi|74203980|dbj|BAE28997.1| unnamed protein product [Mus musculus]
Length = 407
Score = 575 bits (1481), Expect = e-162, Method: Composition-based stats.
Identities = 311/405 (76%), Positives = 339/405 (83%), Gaps = 12/405 (2%)
Query: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 60
MLSE LLVSAPGKVILHGEHAVVHGKVALA +LNLRTFL L+P SNGKV ++LPNIGIK+
Sbjct: 1 MLSEALLVSAPGKVILHGEHAVVHGKVALAAALNLRTFLLLRPQSNGKVSVNLPNIGIKQ 60
Query: 61 AWDVARLQSLDTSFL------------EQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLA 108
WDV LQ LDTSFL EQGDV+ PT EQ+EKLK++ LP D A E +A
Sbjct: 61 VWDVGMLQRLDTSFLGLSPTCLFARVTEQGDVSVPTLEQLEKLKKMGDLPRDRAGNEGMA 120
Query: 109 VLAFLYLYLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPL 168
+LAFLYLYL+ICRKQR LPSLD+VVWSELPPGAGLGSSAAYSVCLAAALLT CEE+ NPL
Sbjct: 121 LLAFLYLYLAICRKQRTLPSLDMVVWSELPPGAGLGSSAAYSVCLAAALLTACEEVSNPL 180
Query: 169 KDGDCVNRWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSP 228
KDG V+RW +EDL+ INKWAF+GER+IHGNPSGVDNAVSTWGGALR+ QG +SSLK P
Sbjct: 181 KDGVSVSRWPEEDLKSINKWAFEGERVIHGNPSGVDNAVSTWGGALRFQQGTMSSLKSLP 240
Query: 229 ALQILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAP 288
+LQILLTNTKVPR+T+ALVA VR+RL KFPEIVAPLLTSIDAISLECERVLGEM AP P
Sbjct: 241 SLQILLTNTKVPRSTKALVAAVRSRLTKFPEIVAPLLTSIDAISLECERVLGEMVAAPVP 300
Query: 289 EQYLVLEELIDMNQHHLNALGVGHASLDQLCQVTRARGLHSKLTXXXXXXXXITLLKPGL 348
EQYLVLEELIDMNQHHLNALGVGH SLDQLCQVT A GLHSKLT ITLLKPGL
Sbjct: 301 EQYLVLEELIDMNQHHLNALGVGHNSLDQLCQVTAAHGLHSKLTGAGGGGCGITLLKPGL 360
Query: 349 EQPEVEATKQALTSCGFDCLETSIGAPGVSIHSATSLDSRVQQAL 393
EQ VEA KQALTSCGFDC ETSIGAPGVS HSA ++ V+QAL
Sbjct: 361 EQATVEAAKQALTSCGFDCWETSIGAPGVSTHSAAAVGDPVRQAL 405
>gi|126324791|ref|XP_001364115.1| PREDICTED: similar to mevalonate kinase [Monodelphis domestica]
Length = 396
Score = 551 bits (1419), Expect = e-155, Method: Composition-based stats.
Identities = 279/396 (70%), Positives = 319/396 (80%)
Query: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 60
ML E LLVSAPGKVILHGEHAVVHGKVALA +LNLRTFLR++PH +GKV L LPN+ R
Sbjct: 1 MLPETLLVSAPGKVILHGEHAVVHGKVALAEALNLRTFLRMRPHKDGKVRLVLPNLETSR 60
Query: 61 AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC 120
WDV++LQ L SFL+ G+ T PT+EQVEKLK AG + E LAVLAFLYLYL IC
Sbjct: 61 EWDVSKLQLLHASFLDSGEPTAPTTEQVEKLKAFAGFMTGSSERECLAVLAFLYLYLFIC 120
Query: 121 RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE 180
RK R LPS+DIVVWSELP GAGLGSSAAYSVCLAAALL CEEI N LK+G RW ++
Sbjct: 121 RKHRPLPSMDIVVWSELPTGAGLGSSAAYSVCLAAALLASCEEIMNRLKEGATSARWNED 180
Query: 181 DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP 240
+L LIN+WAF GE++IHGNPSGVDN+VSTWGGALR+ +G ISSL+R P L+ILLTNTKVP
Sbjct: 181 ELNLINRWAFLGEKVIHGNPSGVDNSVSTWGGALRFQKGNISSLQRIPVLKILLTNTKVP 240
Query: 241 RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM 300
R+T+ALVA V++RL KFPEI+ PLL SIDAIS ECERVLG M P PEQY+VLEELIDM
Sbjct: 241 RSTKALVASVKDRLAKFPEIMNPLLVSIDAISQECERVLGVMAATPTPEQYMVLEELIDM 300
Query: 301 NQHHLNALGVGHASLDQLCQVTRARGLHSKLTXXXXXXXXITLLKPGLEQPEVEATKQAL 360
NQHHLNA+GVGH+SLD+LCQVT A GLHSKLT TLL+PGL+Q VEA KQAL
Sbjct: 301 NQHHLNAIGVGHSSLDRLCQVTAAHGLHSKLTGAGGGGCGFTLLRPGLDQSVVEAIKQAL 360
Query: 361 TSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL 396
TSCGF+C ET+IG PGVS+HS SL + V QAL+ L
Sbjct: 361 TSCGFECWETTIGGPGVSLHSEASLKANVLQALNSL 396
>gi|82898655|ref|XP_918559.1| PREDICTED: similar to mevalonate kinase [Mus musculus]
Length = 382
Score = 514 bits (1325), Expect = e-144, Method: Composition-based stats.
Identities = 278/367 (75%), Positives = 308/367 (83%)
Query: 27 VALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKRAWDVARLQSLDTSFLEQGDVTTPTSE 86
VALA +LNLRTFL L+P SNGKV ++LPNIGIK+ WDV LQ LDTSFLEQGDV+ PT E
Sbjct: 14 VALAAALNLRTFLLLRPQSNGKVSVNLPNIGIKQVWDVGMLQRLDTSFLEQGDVSVPTLE 73
Query: 87 QVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSICRKQRALPSLDIVVWSELPPGAGLGSS 146
Q+EKLK++ LP D A E +A+LAFLYLYL+ICRKQR LPSLD+VVWSELPPGAGLGSS
Sbjct: 74 QLEKLKKMGDLPRDRAGNEGMALLAFLYLYLAICRKQRTLPSLDMVVWSELPPGAGLGSS 133
Query: 147 AAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKEDLELINKWAFQGERMIHGNPSGVDNA 206
AAYSVCLAAALLT CEE+ NPLKDG V+RW +EDL+ INKWAF+GER+IHGNPSGVDNA
Sbjct: 134 AAYSVCLAAALLTACEEVSNPLKDGVSVSRWPEEDLKSINKWAFEGERVIHGNPSGVDNA 193
Query: 207 VSTWGGALRYHQGKISSLKRSPALQILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLT 266
+STWG ++ + S L R P+LQILLTNTKVPR+T+ALVA VR+RL KFPEIVAPLLT
Sbjct: 194 ISTWGKSVCSLSSRESRLSRLPSLQILLTNTKVPRSTKALVAAVRSRLTKFPEIVAPLLT 253
Query: 267 SIDAISLECERVLGEMGEAPAPEQYLVLEELIDMNQHHLNALGVGHASLDQLCQVTRARG 326
SIDAISLECERVLGEM AP PEQYLVLEELIDMNQHHLNALGVGH SLDQLCQVT A G
Sbjct: 254 SIDAISLECERVLGEMVAAPVPEQYLVLEELIDMNQHHLNALGVGHNSLDQLCQVTAAHG 313
Query: 327 LHSKLTXXXXXXXXITLLKPGLEQPEVEATKQALTSCGFDCLETSIGAPGVSIHSATSLD 386
LHSKLT ITLLKPGLEQ VEA KQALTSCGFDC ETSIGAPGVS HSA ++
Sbjct: 314 LHSKLTGAGGGGCGITLLKPGLEQATVEAAKQALTSCGFDCWETSIGAPGVSTHSAAAVG 373
Query: 387 SRVQQAL 393
V+QAL
Sbjct: 374 DPVRQAL 380
>gi|123227559|emb|CAM15186.1| novel protein similar to vertebrate mevalonate kinase (mevalonic
aciduria) (MVK) [Danio rerio]
Length = 396
Score = 419 bits (1077), Expect = e-115, Method: Composition-based stats.
Identities = 216/396 (54%), Positives = 286/396 (72%), Gaps = 4/396 (1%)
Query: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 60
M S L VSAPGKVILHGEH+VVHGKVALAVS+NLRT+LRLQ S+G+V ++LPNI
Sbjct: 1 MQSRELFVSAPGKVILHGEHSVVHGKVALAVSVNLRTYLRLQSTSSGQVCINLPNIDTFL 60
Query: 61 AWDVARLQSL-DTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSI 119
+W++ LQ L S EQ D ++ ++KL+E G+ DD T +AVLAFLY+Y+++
Sbjct: 61 SWEITALQPLLAGSKAEQRDPKELDADLLKKLREFTGISDDSTDTRSMAVLAFLYMYITV 120
Query: 120 CRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTK 179
+ +L S+ + VWSELP GAGLGSSAAY+VCL+AALL+ I L RW+K
Sbjct: 121 FAE--SLASITVSVWSELPTGAGLGSSAAYNVCLSAALLSARGNISPLLMAQQESARWSK 178
Query: 180 EDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKV 239
+++ELIN+WAF GE++IHGNPSGVDNAV TWGG LRYH G I+ L P L+ILLTNTKV
Sbjct: 179 DEMELINRWAFMGEKIIHGNPSGVDNAVGTWGGFLRYHSGNITPLSWVPILRILLTNTKV 238
Query: 240 PRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGE-APAPEQYLVLEELI 298
PR+T+ LV+GV++++ KFP ++ P+L S+ A+S CE+ L EM E P+ E Y +LEELI
Sbjct: 239 PRSTKVLVSGVKDKINKFPSVMRPVLESVSAVSCTCEQTLTEMAEHGPSAEHYNILEELI 298
Query: 299 DMNQHHLNALGVGHASLDQLCQVTRARGLHSKLTXXXXXXXXITLLKPGLEQPEVEATKQ 358
D+NQHHLN +GVGH+SLD LC+VT ++GLHSKLT ITLL+P + +++T +
Sbjct: 299 DINQHHLNVMGVGHSSLDTLCRVTLSKGLHSKLTGAGGGGCGITLLRPETDTSVIQSTVE 358
Query: 359 ALTSCGFDCLETSIGAPGVSIHSATSLDSRVQQALD 394
L +CGFDC ETSIGAPGV HS+ ++ V + L+
Sbjct: 359 ELKACGFDCWETSIGAPGVQQHSSAAISPDVLKILN 394
>gi|55925207|ref|NP_001007350.1| hypothetical protein LOC492477 [Danio rerio]
gi|55250855|gb|AAH85528.1| Zgc:103473 [Danio rerio]
Length = 396
Score = 418 bits (1074), Expect = e-115, Method: Composition-based stats.
Identities = 216/396 (54%), Positives = 285/396 (71%), Gaps = 4/396 (1%)
Query: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 60
M S L VSAPGKVILHGEH+VVHGKVALAVS+NLRT+LRLQ S+G+V ++LPNI
Sbjct: 1 MQSRELFVSAPGKVILHGEHSVVHGKVALAVSVNLRTYLRLQSTSSGQVCINLPNIDTFL 60
Query: 61 AWDVARLQSL-DTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSI 119
+W++ LQ L S EQ D ++ ++KL+E G+ DD T +AVLAFLY+YL++
Sbjct: 61 SWEITALQPLLAGSKAEQRDPKELDADLLKKLREFTGISDDSTDTRSMAVLAFLYMYLTV 120
Query: 120 CRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTK 179
+ +L S+ + VWSELP GAGLGSSAAY+VCL+AALL+ I L RW+K
Sbjct: 121 FAE--SLASITVSVWSELPTGAGLGSSAAYNVCLSAALLSARGNISPLLMAQQESARWSK 178
Query: 180 EDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKV 239
+++ELIN+WAF GE++IHGNPSGVDNAV TWGG LRYH G I+ L P L+ILLTNTKV
Sbjct: 179 DEMELINRWAFMGEKIIHGNPSGVDNAVGTWGGFLRYHSGNITPLSWVPILRILLTNTKV 238
Query: 240 PRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGE-APAPEQYLVLEELI 298
PR+T+ LV+GV++++ KFP ++ P+L S+ A+S CE+ L EM E P+ E Y +LEELI
Sbjct: 239 PRSTKVLVSGVKDKINKFPSVMRPVLESVSAVSCTCEQTLTEMAEHGPSAEHYNILEELI 298
Query: 299 DMNQHHLNALGVGHASLDQLCQVTRARGLHSKLTXXXXXXXXITLLKPGLEQPEVEATKQ 358
D+NQHHLN +GVGH+SLD LC+VT ++GLHSKLT ITLL+P + +++ +
Sbjct: 299 DINQHHLNVMGVGHSSLDTLCRVTLSKGLHSKLTGAGGGGCGITLLRPETDTSVIQSAVE 358
Query: 359 ALTSCGFDCLETSIGAPGVSIHSATSLDSRVQQALD 394
L +CGFDC ETSIGAPGV HS+ ++ V + L+
Sbjct: 359 ELKACGFDCWETSIGAPGVQQHSSAAISPDVLKILN 394
>gi|61555394|gb|AAX46707.1| mevalonate kinase [Bos taurus]
Length = 363
Score = 416 bits (1069), Expect = e-114, Method: Composition-based stats.
Identities = 207/253 (81%), Positives = 223/253 (88%)
Query: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 60
MLSEVLLVSAPGKVILHGEHAVVHGKVALAV+LNLRTFLRLQPHSNG+V L+LPNIG++R
Sbjct: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVALNLRTFLRLQPHSNGRVGLNLPNIGVRR 60
Query: 61 AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC 120
AWDVA LQ LDTSFL GD T++ VEKLKEVAG P DC E LAVLAFLYLYLSIC
Sbjct: 61 AWDVASLQLLDTSFLGHGDSAALTAKHVEKLKEVAGFPKDCVDPEHLAVLAFLYLYLSIC 120
Query: 121 RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE 180
+ QR LPSLDI VWSELP GAGLGSSAAYSVCLAAALLT CEEIPNPLKDG+ RWT+E
Sbjct: 121 QSQRVLPSLDITVWSELPTGAGLGSSAAYSVCLAAALLTACEEIPNPLKDGEAAGRWTEE 180
Query: 181 DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP 240
+LELINKWAFQGER+IHGNPSGVDNAVSTWGGALRY QGKISSLKR P L+ILL NTKVP
Sbjct: 181 NLELINKWAFQGERVIHGNPSGVDNAVSTWGGALRYQQGKISSLKRPPVLKILLINTKVP 240
Query: 241 RNTRALVAGVRNR 253
R+T+ LVA VR+R
Sbjct: 241 RSTKVLVANVRSR 253
>gi|47226511|emb|CAG08527.1| unnamed protein product [Tetraodon nigroviridis]
Length = 394
Score = 401 bits (1030), Expect = e-110, Method: Composition-based stats.
Identities = 215/390 (55%), Positives = 267/390 (68%), Gaps = 3/390 (0%)
Query: 6 LLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKRAWDVA 65
+ VSAPGK ILHGEHAVVHGKVALAVSLNLR++LRL+ S G V ++LPNI W+++
Sbjct: 6 IYVSAPGKAILHGEHAVVHGKVALAVSLNLRSYLRLEATSTGTVGVNLPNIDTFLHWNLS 65
Query: 66 RLQSLDTSFLE-QGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSICRKQR 124
L+ S G V + + +L+E G+ + T ++A L FLYLYLS
Sbjct: 66 ELKQFAPSVTGGTGQVKLLDPDLLRRLREYVGVANGNLNTSQMATLTFLYLYLS-AFGSG 124
Query: 125 ALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKEDLEL 184
LPSL + VWSELP GAGLGSSAAY+VCLAAALL I +PLK+ + RW +E+LEL
Sbjct: 125 ELPSLTVSVWSELPTGAGLGSSAAYTVCLAAALLCASGAISSPLKEWEHTARWCQEELEL 184
Query: 185 INKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVPRNTR 244
IN WAFQGE +IHGNPSGVDNAV TWGG LR+ GKI L R P L+ILLTNTKVPR+T+
Sbjct: 185 INSWAFQGEMIIHGNPSGVDNAVGTWGGMLRFLAGKIIPLSRVPLLRILLTNTKVPRSTK 244
Query: 245 ALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAP-APEQYLVLEELIDMNQH 303
LV+ V++++ KFP ++AP+L S+DAIS CE+VL EM P E Y LEELID+NQH
Sbjct: 245 VLVSRVKDKINKFPSVMAPVLDSVDAISCTCEKVLSEMTSEPITGEHYNALEELIDINQH 304
Query: 304 HLNALGVGHASLDQLCQVTRARGLHSKLTXXXXXXXXITLLKPGLEQPEVEATKQALTSC 363
HLN +GVGH +LD LC++T +GLHSKLT ITLL+P V+AT Q L C
Sbjct: 305 HLNVMGVGHPALDTLCRITLTKGLHSKLTGAGGGGCGITLLRPETGSAVVQATVQDLKDC 364
Query: 364 GFDCLETSIGAPGVSIHSATSLDSRVQQAL 393
GFDC ETSIG PGV H+ S+ + + L
Sbjct: 365 GFDCWETSIGGPGVQQHAPVSVKEEILEVL 394
>gi|119618276|gb|EAW97870.1| mevalonate kinase (mevalonic aciduria), isoform CRA_a [Homo
sapiens]
Length = 202
Score = 378 bits (970), Expect = e-103, Method: Composition-based stats.
Identities = 194/202 (96%), Positives = 194/202 (96%)
Query: 195 MIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVPRNTRALVAGVRNRL 254
MIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVPRNTRALVAGVRNRL
Sbjct: 1 MIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVPRNTRALVAGVRNRL 60
Query: 255 LKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDMNQHHLNALGVGHAS 314
LKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDMNQHHLNALGVGHAS
Sbjct: 61 LKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDMNQHHLNALGVGHAS 120
Query: 315 LDQLCQVTRARGLHSKLTXXXXXXXXITLLKPGLEQPEVEATKQALTSCGFDCLETSIGA 374
LDQLCQVTRARGLHSKLT ITLLKPGLEQPEVEATKQALTSCGFDCLETSIGA
Sbjct: 121 LDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQALTSCGFDCLETSIGA 180
Query: 375 PGVSIHSATSLDSRVQQALDGL 396
PGVSIHSATSLDSRVQQALDGL
Sbjct: 181 PGVSIHSATSLDSRVQQALDGL 202
>gi|72125755|ref|XP_790690.1| PREDICTED: similar to Mevalonate kinase (MK) [Strongylocentrotus
purpuratus]
gi|115614665|ref|XP_001200159.1| PREDICTED: similar to Mevalonate kinase (MK) [Strongylocentrotus
purpuratus]
Length = 413
Score = 311 bits (798), Expect = 4e-83, Method: Composition-based stats.
Identities = 172/385 (44%), Positives = 245/385 (63%), Gaps = 14/385 (3%)
Query: 6 LLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKRAWDVA 65
+ +SAPGK+ILHGEHAVVHGK ALA LNLR++L L+ +G++ L+LP+I ++R+WDV
Sbjct: 16 IFISAPGKIILHGEHAVVHGKTALAAGLNLRSYLCLKEKDSGRLHLNLPDIDLERSWDVL 75
Query: 66 RLQS-----LDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC 120
LQ L++ +E P+ E +++L+ G D T+RLAV+AFLYLYL I
Sbjct: 76 ELQEQFRDLLNSDVME----VKPSVEIMQRLRLFLGY-SDTETTKRLAVMAFLYLYLCIA 130
Query: 121 RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE 180
+ P LD +V S LPPGAGLGSSAA+SVCLAA LLT + I PL D W++E
Sbjct: 131 GRNGKFPILDTLVSSALPPGAGLGSSAAFSVCLAAGLLTWAKAII-PLSLSDNTLDWSRE 189
Query: 181 DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP 240
D+ELIN WA++GER+IHGNPSG+DN++S GGA+ Y Q I+ L+ P L ILL NT V
Sbjct: 190 DMELINTWAYEGERVIHGNPSGIDNSISVHGGAIEYRQKVITPLENMPELSILLVNTCVA 249
Query: 241 RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQ---YLVLEEL 297
R+T+ LVAGV+ R K+P++ P+L SI+ IS EC+R L + + ++ + L EL
Sbjct: 250 RSTKELVAGVQRRHDKYPKVYGPILDSIEEISQECKRTLQALKTGESLDKDGAFKSLGEL 309
Query: 298 IDMNQHHLNALGVGHASLDQLCQVTRARGLHSKLTXXXXXXXXITLLKPGLEQPEVEATK 357
+D+NQ L +GV H +++ + + A +H+KLT LL P + + V+A +
Sbjct: 310 VDINQQLLYVIGVSHPAINNIVRSAAAYKIHAKLTGAGGGGCVFALLPPDIPKDSVKALQ 369
Query: 358 QALTSCGFDCLETSIGAPGVSIHSA 382
L ++ TS+GA GV +H +
Sbjct: 370 ADLFRHNYESWITSLGAHGVMMHRS 394
>gi|148687960|gb|EDL19907.1| mevalonate kinase, isoform CRA_a [Mus musculus]
gi|148687961|gb|EDL19908.1| mevalonate kinase, isoform CRA_a [Mus musculus]
Length = 221
Score = 266 bits (681), Expect = 2e-69, Method: Composition-based stats.
Identities = 149/214 (69%), Positives = 169/214 (78%), Gaps = 17/214 (7%)
Query: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 60
MLSE LLVS VALA +LNLRTFL L+P SNGKV ++LPNIGIK+
Sbjct: 1 MLSEALLVS-----------------VALAAALNLRTFLLLRPQSNGKVSVNLPNIGIKQ 43
Query: 61 AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC 120
WDV LQ LDTSFLEQGDV+ PT EQ+EKLK++ LP D A E +A+LAFLYLYL+IC
Sbjct: 44 VWDVGMLQRLDTSFLEQGDVSVPTLEQLEKLKKMGDLPRDRAGNEGMALLAFLYLYLAIC 103
Query: 121 RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE 180
RKQR LPSLD+VVWSELPPGAGLGSSAAYSVCLAAALLT CEE+ NPLKDG V+RW +E
Sbjct: 104 RKQRTLPSLDMVVWSELPPGAGLGSSAAYSVCLAAALLTACEEVSNPLKDGVSVSRWPEE 163
Query: 181 DLELINKWAFQGERMIHGNPSGVDNAVSTWGGAL 214
DL+ INKWAF+GER+IHGNPSGVDNA+STW L
Sbjct: 164 DLKSINKWAFEGERVIHGNPSGVDNAISTWASRL 197
>gi|149063615|gb|EDM13938.1| mevalonate kinase, isoform CRA_b [Rattus norvegicus]
Length = 255
Score = 258 bits (660), Expect = 4e-67, Method: Composition-based stats.
Identities = 135/181 (74%), Positives = 154/181 (85%)
Query: 34 NLRTFLRLQPHSNGKVDLSLPNIGIKRAWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKE 93
NLRTFL L+P SNGKV L+LPN+GIK+ WDVA LQ LDT FLEQGDV PT EQ+EKLK+
Sbjct: 51 NLRTFLVLRPQSNGKVSLNLPNVGIKQVWDVATLQLLDTGFLEQGDVPAPTLEQLEKLKK 110
Query: 94 VAGLPDDCAVTERLAVLAFLYLYLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCL 153
VAGLP DC E L++LAFLYLYL+ICRKQR LPSLDI+VWSELPPGAGLGSSAAYSVC+
Sbjct: 111 VAGLPRDCVGNEGLSLLAFLYLYLAICRKQRTLPSLDIMVWSELPPGAGLGSSAAYSVCV 170
Query: 154 AAALLTVCEEIPNPLKDGDCVNRWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGA 213
AAALLT CEE+ NPLKD + W +EDL+ INKWA++GER+IHGNPSGVDN+VSTWG
Sbjct: 171 AAALLTACEEVTNPLKDRGSIGSWPEEDLKSINKWAYEGERVIHGNPSGVDNSVSTWGSQ 230
Query: 214 L 214
L
Sbjct: 231 L 231
>gi|149063616|gb|EDM13939.1| mevalonate kinase, isoform CRA_c [Rattus norvegicus]
Length = 219
Score = 256 bits (655), Expect = 2e-66, Method: Composition-based stats.
Identities = 135/181 (74%), Positives = 154/181 (85%)
Query: 34 NLRTFLRLQPHSNGKVDLSLPNIGIKRAWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKE 93
NLRTFL L+P SNGKV L+LPN+GIK+ WDVA LQ LDT FLEQGDV PT EQ+EKLK+
Sbjct: 15 NLRTFLVLRPQSNGKVSLNLPNVGIKQVWDVATLQLLDTGFLEQGDVPAPTLEQLEKLKK 74
Query: 94 VAGLPDDCAVTERLAVLAFLYLYLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCL 153
VAGLP DC E L++LAFLYLYL+ICRKQR LPSLDI+VWSELPPGAGLGSSAAYSVC+
Sbjct: 75 VAGLPRDCVGNEGLSLLAFLYLYLAICRKQRTLPSLDIMVWSELPPGAGLGSSAAYSVCV 134
Query: 154 AAALLTVCEEIPNPLKDGDCVNRWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGA 213
AAALLT CEE+ NPLKD + W +EDL+ INKWA++GER+IHGNPSGVDN+VSTWG
Sbjct: 135 AAALLTACEEVTNPLKDRGSIGSWPEEDLKSINKWAYEGERVIHGNPSGVDNSVSTWGSQ 194
Query: 214 L 214
L
Sbjct: 195 L 195
>gi|58260882|ref|XP_567851.1| cystathionine beta-lyase [Cryptococcus neoformans var. neoformans
JEC21]
gi|134117159|ref|XP_772806.1| hypothetical protein CNBK1800 [Cryptococcus neoformans var.
neoformans B-3501A]
gi|50255424|gb|EAL18159.1| hypothetical protein CNBK1800 [Cryptococcus neoformans var.
neoformans B-3501A]
gi|57229932|gb|AAW46334.1| cystathionine beta-lyase, putative [Cryptococcus neoformans var.
neoformans JEC21]
Length = 900
Score = 227 bits (578), Expect = 1e-57, Method: Composition-based stats.
Identities = 154/405 (38%), Positives = 212/405 (52%), Gaps = 47/405 (11%)
Query: 2 LSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKRA 61
+ E + VSAPGKVIL GEHAVVHG A+A S++LR F L P +GKV L +PNIG++
Sbjct: 478 IEEDIAVSAPGKVILFGEHAVVHGVTAIASSVDLRCFSVLSPRRDGKVGLEVPNIGVELE 537
Query: 62 WDVARL-----------------QSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVT 104
W++++L + LDT+ L+ + T +V K T
Sbjct: 538 WEISKLPWNLLPVHANGGRHVADKELDTALLQAVEGAVNTHVEVGK-------------T 584
Query: 105 ERLAVLAFLYLYLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEI 164
A +AFLYLY+ I ++ S+ S LP AGLGSSAAYS C+AA+ L + +
Sbjct: 585 GIGACVAFLYLYMMISGEETNALSVTFTASSNLPISAGLGSSAAYSTCVAASFLLARQHL 644
Query: 165 PNPLKDGDCVNRWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRY------HQ 218
P D R KED +L++ WAF E+++HGNPSG+DNAV+ GGA+ + Q
Sbjct: 645 TIPSAD-----RLPKEDTDLVDGWAFLAEKVLHGNPSGIDNAVAVRGGAVAFTRSVGGKQ 699
Query: 219 GKISSLKRSPALQILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERV 278
G + L ++++LLTNT VPR+T+ LVAGV + L P+ V +L SI IS E +
Sbjct: 700 GGMDGLFEFSSVRLLLTNTLVPRDTKTLVAGVSAKRLAEPQAVNSILDSIQTISDEARSL 759
Query: 279 LGEMGEAPAPEQYLV--LEELIDMNQHHLNALGVGHASLDQLCQVTRAR--GLHSKLTXX 334
LG G P LV LE LI N HL LGV H SL+ + T L +KLT
Sbjct: 760 LG--GGKPVERSILVKRLEALIKENHEHLVELGVSHPSLEMIVAATAQAPFELATKLTGA 817
Query: 335 XXXXXXITLLKPGLEQPEVEATKQALTSCGFDCLETSIGAPGVSI 379
+TL+ + + Q L GF T++G PG +
Sbjct: 818 GGGGCALTLIPDDFPESSLNELIQTLEGHGFQAHLTTLGGPGFGV 862