BLASTP 2.2.17 [Aug-26-2007]
Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Reference for composition-based statistics:
Schäffer, Alejandro A., L. Aravind, Thomas L. Madden,
Schaffer, Alejandro A., L. Aravind, Thomas L. Madden,
Sergei Shavirin, John L. Spouge, Yuri I. Wolf,
Eugene V. Koonin, and Stephen F. Altschul (2001),
"Improving the accuracy of PSI-BLAST protein database searches with
composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005.
Query= ENSG00000117305__[Homo_sapiens]
(325 letters)
Database: nr.pal
6,348,806 sequences; 2,166,943,470 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|62198232|ref|NP_000182.2| 3-hydroxymethyl-3-methylglutar... 598 e-169
gi|114554638|ref|XP_001166273.1| PREDICTED: 3-hydroxymethyl... 597 e-169
gi|184503|gb|AAA92733.1| hydroxymethylglutaryl-CoA lyase [H... 597 e-169
gi|61213670|sp|Q5R9E1|HMGCL_PONPY Hydroxymethylglutaryl-CoA... 588 e-166
gi|61213704|sp|Q8HXZ6|HMGCL_MACFA Hydroxymethylglutaryl-CoA... 572 e-162
gi|90077136|dbj|BAE88248.1| unnamed protein product [Macaca... 568 e-160
gi|114554640|ref|XP_513200.2| PREDICTED: similar to 3-hydro... 564 e-159
gi|1292941|gb|AAB19099.1| hydroxymethylglutaryl-CoA lyase 561 e-158
gi|56202566|emb|CAI23161.1| 3-hydroxymethyl-3-methylglutary... 557 e-157
gi|114554642|ref|XP_001166216.1| PREDICTED: similar to 3-hy... 556 e-157
gi|83754896|pdb|2CW6|A Chain A, Crystal Structure Of Human ... 553 e-156
gi|13242293|ref|NP_077362.1| 3-hydroxy-3-methylglutaryl-Coe... 546 e-154
gi|149694251|ref|XP_001504254.1| PREDICTED: similar to inte... 545 e-153
gi|115495073|ref|NP_001068600.1| 3-hydroxymethyl-3-methylgl... 541 e-152
gi|19343556|gb|AAH25440.1| Hmgcl protein [Mus musculus] >gi... 540 e-152
gi|6680233|ref|NP_032280.1| 3-hydroxy-3-methylglutaryl-Coen... 538 e-151
gi|74194970|dbj|BAE26056.1| unnamed protein product [Mus mu... 536 e-150
gi|585257|sp|P38060|HMGCL_MOUSE Hydroxymethylglutaryl-CoA l... 534 e-150
gi|108999140|ref|XP_001104722.1| PREDICTED: 3-hydroxymethyl... 531 e-149
gi|114554644|ref|XP_001166145.1| PREDICTED: similar to 3-hy... 528 e-148
gi|73950222|ref|XP_535360.2| PREDICTED: similar to Hydroxym... 522 e-146
gi|50759896|ref|XP_417834.1| PREDICTED: similar to Hydroxym... 473 e-131
gi|126328575|ref|XP_001363832.1| PREDICTED: similar to alph... 460 e-128
gi|547653|sp|P35915|HMGCL_CHICK Hydroxymethylglutaryl-CoA l... 456 e-127
gi|41055014|ref|NP_957509.1| hypothetical protein LOC394190... 448 e-124
gi|211947|gb|AAA92728.1| hydroxymethylglutaryl-CoA lyase 446 e-123
gi|148232581|ref|NP_001085152.1| hypothetical protein LOC43... 444 e-123
gi|47219546|emb|CAG09900.1| unnamed protein product [Tetrao... 440 e-122
gi|19526275|gb|AAL89669.1|AF411956_10 hydroxymethylglutaryl... 431 e-119
gi|73973416|ref|XP_538973.2| PREDICTED: similar to 3-hydrox... 429 e-118
gi|109071671|ref|XP_001105003.1| PREDICTED: similar to 3-hy... 427 e-118
gi|149732643|ref|XP_001499476.1| PREDICTED: similar to 3-hy... 427 e-118
gi|109150427|ref|NP_061909.2| 3-hydroxymethyl-3-methylgluta... 427 e-118
gi|109150422|ref|NP_001035865.1| 3-hydroxymethyl-3-methylgl... 427 e-118
gi|50744846|ref|XP_419903.1| PREDICTED: similar to 3-hydrox... 426 e-117
gi|126310275|ref|XP_001371535.1| PREDICTED: similar to 3-hy... 420 e-116
gi|149019133|gb|EDL77774.1| similar to 3-hydroxymethyl-3-me... 419 e-115
gi|33239379|ref|NP_776092.1| 3-hydroxymethyl-3-methylglutar... 418 e-115
gi|119915033|ref|XP_615612.3| PREDICTED: similar to 3-hydro... 416 e-114
gi|62653916|ref|XP_345954.2| PREDICTED: similar to 3-hydrox... 415 e-114
gi|119915031|ref|XP_001252308.1| PREDICTED: similar to 3-hy... 414 e-114
gi|160333724|ref|NP_001103870.1| hypothetical protein LOC57... 412 e-113
gi|115749044|ref|XP_001196745.1| PREDICTED: similar to MGC8... 393 e-108
gi|156399405|ref|XP_001638492.1| predicted protein [Nematos... 373 e-102
gi|158293482|ref|XP_314824.4| AGAP008717-PA [Anopheles gamb... 369 e-100
gi|157126265|ref|XP_001654565.1| hydroxymethylglutaryl-coa ... 369 e-100
gi|125984033|ref|XP_001355781.1| GA10298-PA [Drosophila pse... 367 e-100
gi|84453198|dbj|BAE71196.1| putative hydroxymethylglutaryl-... 365 2e-99
gi|170031762|ref|XP_001843753.1| hydroxymethylglutaryl-CoA ... 364 4e-99
gi|125525336|gb|EAY73450.1| hypothetical protein OsI_001297... 363 1e-98
gi|125569854|gb|EAZ11369.1| hypothetical protein OsJ_001194... 363 1e-98
gi|108862158|gb|ABA95738.2| Hydroxymethylglutaryl-CoA lyase... 362 2e-98
gi|18401240|ref|NP_565629.1| hydroxymethylglutaryl-CoA lyas... 361 4e-98
gi|157343219|emb|CAO67270.1| unnamed protein product [Vitis... 360 6e-98
gi|66772937|gb|AAY55779.1| IP10508p [Drosophila melanogaster] 360 1e-97
gi|115484067|ref|NP_001065695.1| Os11g0137200 [Oryza sativa... 359 1e-97
gi|24582381|ref|NP_609089.1| CG10399 CG10399-PA [Drosophila... 359 1e-97
gi|115487212|ref|NP_001066093.1| Os12g0134000 [Oryza sativa... 358 4e-97
gi|167533391|ref|XP_001748375.1| predicted protein [Monosig... 357 5e-97
gi|168030137|ref|XP_001767580.1| predicted protein [Physcom... 357 6e-97
gi|30683260|ref|NP_850087.1| hydroxymethylglutaryl-CoA lyas... 357 7e-97
gi|144899161|emb|CAM76025.1| Pyruvate carboxyltransferase [... 355 3e-96
gi|56783756|dbj|BAD81168.1| putative hydroxymethylglutaryl-... 355 3e-96
gi|23016672|ref|ZP_00056425.1| COG0119: Isopropylmalate/hom... 354 4e-96
gi|115435876|ref|NP_001042696.1| Os01g0269000 [Oryza sativa... 354 4e-96
gi|66810321|ref|XP_638884.1| hydroxymethylglutaryl-CoA lyas... 354 6e-96
gi|149911150|ref|ZP_01899775.1| Hydroxymethylglutaryl-CoA l... 352 2e-95
gi|71905728|ref|YP_283315.1| Pyruvate carboxyltransferase [... 351 4e-95
gi|88813679|ref|ZP_01128907.1| Pyruvate carboxyltransferase... 350 7e-95
gi|163750398|ref|ZP_02157638.1| hydroxymethylglutaryl-CoA l... 350 8e-95
gi|157347577|emb|CAO18214.1| unnamed protein product [Vitis... 350 8e-95
gi|124360527|gb|ABN08537.1| Pyruvate carboxyltransferase [M... 348 2e-94
gi|87120147|ref|ZP_01076043.1| 3-hydroxymethylglutaryl-CoA ... 348 3e-94
gi|157962622|ref|YP_001502656.1| pyruvate carboxyltransfera... 347 5e-94
gi|146307057|ref|YP_001187522.1| hydroxymethylglutaryl-CoA ... 346 1e-93
gi|83309772|ref|YP_420036.1| Isopropylmalate/homocitrate/ci... 346 1e-93
gi|71280227|ref|YP_268341.1| hydroxymethylglutaryl-CoA lyas... 345 2e-93
gi|109899236|ref|YP_662491.1| pyruvate carboxyltransferase ... 345 3e-93
gi|157374593|ref|YP_001473193.1| pyruvate carboxyltransfera... 344 5e-93
gi|94502147|ref|ZP_01308647.1| hydroxymethylglutaryl-CoA ly... 344 6e-93
gi|84326699|ref|ZP_00974724.1| COG0119: Isopropylmalate/hom... 343 8e-93
gi|167624821|ref|YP_001675115.1| pyruvate carboxyltransfera... 343 1e-92
gi|127513502|ref|YP_001094699.1| pyruvate carboxyltransfera... 343 1e-92
gi|168038042|ref|XP_001771511.1| predicted protein [Physcom... 342 2e-92
gi|108755216|emb|CAK32536.1| Hydroxymethylglutaryl-CoA lyas... 340 6e-92
gi|57209295|emb|CAI40662.1| novel protein similar to 3-hydr... 340 6e-92
gi|120555041|ref|YP_959392.1| pyruvate carboxyltransferase ... 340 8e-92
gi|146283542|ref|YP_001173695.1| hydroxymethylglutaryl-CoA ... 340 8e-92
gi|77165359|ref|YP_343884.1| Pyruvate carboxyltransferase [... 340 9e-92
gi|170727566|ref|YP_001761592.1| pyruvate carboxyltransfera... 340 1e-91
gi|119774495|ref|YP_927235.1| pyruvate carboxyltransferase ... 340 1e-91
gi|67155614|ref|ZP_00417242.1| HMG-CoA lyase-like [Azotobac... 339 1e-91
gi|89092352|ref|ZP_01165306.1| Pyruvate carboxyltransferase... 338 2e-91
gi|149377182|ref|ZP_01894930.1| 3-hydroxymethylglutaryl-CoA... 338 3e-91
gi|119477419|ref|ZP_01617610.1| hydroxymethylglutaryl-CoA l... 338 3e-91
gi|145480821|ref|XP_001426433.1| hypothetical protein GSPAT... 338 4e-91
gi|126667844|ref|ZP_01738810.1| 3-hydroxymethylglutaryl-CoA... 337 5e-91
gi|118384118|ref|XP_001025212.1| HMGL-like family protein [... 336 1e-90
gi|56478076|ref|YP_159665.1| 3-hydroxymethylglutaryl-CoA or... 335 2e-90
gi|119615503|gb|EAW95097.1| 3-hydroxymethyl-3-methylglutary... 335 2e-90
>gi|62198232|ref|NP_000182.2| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase
(hydroxymethylglutaricaciduria) [Homo sapiens]
gi|24418852|sp|P35914|HMGCL_HUMAN Hydroxymethylglutaryl-CoA lyase, mitochondrial precursor (HMG-CoA
lyase) (HL) (3-hydroxy-3-methylglutarate-CoA lyase)
gi|14714839|gb|AAH10570.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase
(hydroxymethylglutaricaciduria) [Homo sapiens]
gi|32879927|gb|AAP88794.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase
(hydroxymethylglutaricaciduria) [Homo sapiens]
gi|48145885|emb|CAG33165.1| HMGCL [Homo sapiens]
gi|60654783|gb|AAX31956.1| 3-hydroxymethyl-3-methylglutaryl-coenzyme A lyase [synthetic
construct]
gi|60654785|gb|AAX31957.1| 3-hydroxymethyl-3-methylglutaryl-coenzyme A lyase [synthetic
construct]
gi|60654787|gb|AAX31958.1| 3-hydroxymethyl-3-methylglutaryl-coenzyme A lyase [synthetic
construct]
gi|60654789|gb|AAX31959.1| 3-hydroxymethyl-3-methylglutaryl-coenzyme A lyase [synthetic
construct]
gi|119615500|gb|EAW95094.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase
(hydroxymethylglutaricaciduria), isoform CRA_a [Homo
sapiens]
gi|123982536|gb|ABM83009.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase
(hydroxymethylglutaricaciduria) [synthetic construct]
gi|123997201|gb|ABM86202.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase
(hydroxymethylglutaricaciduria) [synthetic construct]
Length = 325
Score = 598 bits (1543), Expect = e-169, Method: Composition-based stats.
Identities = 311/325 (95%), Positives = 311/325 (95%)
Query: 1 MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI
Sbjct: 1 MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
Query: 61 DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLXXXXXXXXXX 120
DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNL
Sbjct: 61 DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAG 120
Query: 121 XXXXVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
VIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI
Sbjct: 121 AKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
Query: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ
Sbjct: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
Query: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL
Sbjct: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
Query: 301 EAGNFICQALNRKTSSKVAQATCKL 325
EAGNFICQALNRKTSSKVAQATCKL
Sbjct: 301 EAGNFICQALNRKTSSKVAQATCKL 325
>gi|114554638|ref|XP_001166273.1| PREDICTED: 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase
(hydroxymethylglutaricaciduria) isoform 3 [Pan
troglodytes]
Length = 325
Score = 597 bits (1540), Expect = e-169, Method: Composition-based stats.
Identities = 310/325 (95%), Positives = 311/325 (95%)
Query: 1 MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKL+
Sbjct: 1 MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLV 60
Query: 61 DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLXXXXXXXXXX 120
DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNL
Sbjct: 61 DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAG 120
Query: 121 XXXXVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
VIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI
Sbjct: 121 AKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
Query: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ
Sbjct: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
Query: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL
Sbjct: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
Query: 301 EAGNFICQALNRKTSSKVAQATCKL 325
EAGNFICQALNRKTSSKVAQATCKL
Sbjct: 301 EAGNFICQALNRKTSSKVAQATCKL 325
>gi|184503|gb|AAA92733.1| hydroxymethylglutaryl-CoA lyase [Homo sapiens]
Length = 325
Score = 597 bits (1539), Expect = e-169, Method: Composition-based stats.
Identities = 310/325 (95%), Positives = 310/325 (95%)
Query: 1 MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI
Sbjct: 1 MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
Query: 61 DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLXXXXXXXXXX 120
DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNL
Sbjct: 61 DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAG 120
Query: 121 XXXXVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
VIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI
Sbjct: 121 AKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
Query: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ
Sbjct: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
Query: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
AL NTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL
Sbjct: 241 ALTNTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
Query: 301 EAGNFICQALNRKTSSKVAQATCKL 325
EAGNFICQALNRKTSSKVAQATCKL
Sbjct: 301 EAGNFICQALNRKTSSKVAQATCKL 325
>gi|61213670|sp|Q5R9E1|HMGCL_PONPY Hydroxymethylglutaryl-CoA lyase, mitochondrial precursor (HMG-CoA
lyase) (HL) (3-hydroxy-3-methylglutarate-CoA lyase)
gi|55729782|emb|CAH91619.1| hypothetical protein [Pongo pygmaeus]
Length = 325
Score = 588 bits (1516), Expect = e-166, Method: Composition-based stats.
Identities = 307/325 (94%), Positives = 308/325 (94%)
Query: 1 MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
MAAMRKA+PRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI
Sbjct: 1 MAAMRKAVPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
Query: 61 DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLXXXXXXXXXX 120
DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNL
Sbjct: 61 DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAG 120
Query: 121 XXXXVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
IFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI
Sbjct: 121 AKEVAIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
Query: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
SPAKVAEVTKK YSMGCYEISLGDTIGVGTPGIMK MLSAVMQEVPLAALAVHCHDTYGQ
Sbjct: 181 SPAKVAEVTKKLYSMGCYEISLGDTIGVGTPGIMKGMLSAVMQEVPLAALAVHCHDTYGQ 240
Query: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL
Sbjct: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
Query: 301 EAGNFICQALNRKTSSKVAQATCKL 325
EAGNFICQALNRKTSSKVAQATCKL
Sbjct: 301 EAGNFICQALNRKTSSKVAQATCKL 325
>gi|61213704|sp|Q8HXZ6|HMGCL_MACFA Hydroxymethylglutaryl-CoA lyase, mitochondrial precursor (HMG-CoA
lyase) (HL) (3-hydroxy-3-methylglutarate-CoA lyase)
gi|23574743|dbj|BAC20595.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase [Macaca
fascicularis]
Length = 325
Score = 572 bits (1475), Expect = e-162, Method: Composition-based stats.
Identities = 299/325 (92%), Positives = 301/325 (92%)
Query: 1 MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
MAAM KALPRRLVGLASLRAVSTSSM TLPK+VKIVEVGPRDGLQNEKNIVSTPVKIKLI
Sbjct: 1 MAAMTKALPRRLVGLASLRAVSTSSMDTLPKQVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
Query: 61 DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLXXXXXXXXXX 120
DMLSEAGLSVIE TSFVSPKWVPQM DH EVLKGIQKFPGI YPVL PNL
Sbjct: 61 DMLSEAGLSVIEATSFVSPKWVPQMADHAEVLKGIQKFPGITYPVLIPNLKGFEAAVAAG 120
Query: 121 XXXXVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
IFGAASELFTKKN+NCSIEESFQRFDAILKAAQSANISVRGYVSC LGCPYEGKI
Sbjct: 121 AKEVSIFGAASELFTKKNVNCSIEESFQRFDAILKAAQSANISVRGYVSCVLGCPYEGKI 180
Query: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVP AALAVHCHDTYGQ
Sbjct: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPPAALAVHCHDTYGQ 240
Query: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL
Sbjct: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
Query: 301 EAGNFICQALNRKTSSKVAQATCKL 325
EAGNFICQALNRKTSSKVAQATCKL
Sbjct: 301 EAGNFICQALNRKTSSKVAQATCKL 325
>gi|90077136|dbj|BAE88248.1| unnamed protein product [Macaca fascicularis]
Length = 325
Score = 568 bits (1465), Expect = e-160, Method: Composition-based stats.
Identities = 298/325 (91%), Positives = 300/325 (92%)
Query: 1 MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
MAAM KALPRRLVGLASLRAVSTSSM TLPK+VKIVEVGPRDGLQN+KNIVSTPVKIKLI
Sbjct: 1 MAAMTKALPRRLVGLASLRAVSTSSMDTLPKQVKIVEVGPRDGLQNKKNIVSTPVKIKLI 60
Query: 61 DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLXXXXXXXXXX 120
DMLSEAGLSVIE TSFVSPKWVPQM DH EVLKGIQKFPGI YPVL PNL
Sbjct: 61 DMLSEAGLSVIEATSFVSPKWVPQMADHAEVLKGIQKFPGITYPVLIPNLKGFEAAVAAG 120
Query: 121 XXXXVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
IFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSC LGCPYEGKI
Sbjct: 121 AKEVSIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCVLGCPYEGKI 180
Query: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVP AALAVHCHDTYGQ
Sbjct: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPPAALAVHCHDTYGQ 240
Query: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQK L
Sbjct: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKPL 300
Query: 301 EAGNFICQALNRKTSSKVAQATCKL 325
EAGNFICQALNRKTSSKVAQATCKL
Sbjct: 301 EAGNFICQALNRKTSSKVAQATCKL 325
>gi|114554640|ref|XP_513200.2| PREDICTED: similar to 3-hydroxymethyl-3-methylglutaryl-Coenzyme A
lyase (hydroxymethylglutaricaciduria) isoform 4 [Pan
troglodytes]
Length = 316
Score = 564 bits (1453), Expect = e-159, Method: Composition-based stats.
Identities = 290/305 (95%), Positives = 291/305 (95%)
Query: 21 VSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPK 80
VSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKL+DMLSEAGLSVIETTSFVSPK
Sbjct: 12 VSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLVDMLSEAGLSVIETTSFVSPK 71
Query: 81 WVPQMGDHTEVLKGIQKFPGINYPVLTPNLXXXXXXXXXXXXXXVIFGAASELFTKKNIN 140
WVPQMGDHTEVLKGIQKFPGINYPVLTPNL VIFGAASELFTKKNIN
Sbjct: 72 WVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNIN 131
Query: 141 CSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEI 200
CSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEI
Sbjct: 132 CSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEI 191
Query: 201 SLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSV 260
SLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSV
Sbjct: 192 SLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSV 251
Query: 261 AGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQ 320
AGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQ
Sbjct: 252 AGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQ 311
Query: 321 ATCKL 325
ATCKL
Sbjct: 312 ATCKL 316
>gi|1292941|gb|AAB19099.1| hydroxymethylglutaryl-CoA lyase
Length = 305
Score = 561 bits (1445), Expect = e-158, Method: Composition-based stats.
Identities = 290/305 (95%), Positives = 291/305 (95%)
Query: 21 VSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPK 80
VSTSSMGTLPKRVKIVEVGP+DGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPK
Sbjct: 1 VSTSSMGTLPKRVKIVEVGPQDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPK 60
Query: 81 WVPQMGDHTEVLKGIQKFPGINYPVLTPNLXXXXXXXXXXXXXXVIFGAASELFTKKNIN 140
WVPQMGDHTEVLKGIQKFPGINYPVLTPNL VIFGAASELFTKKNIN
Sbjct: 61 WVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNIN 120
Query: 141 CSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEI 200
CSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEI
Sbjct: 121 CSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEI 180
Query: 201 SLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSV 260
SLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSV
Sbjct: 181 SLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSV 240
Query: 261 AGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQ 320
AGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQ
Sbjct: 241 AGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQ 300
Query: 321 ATCKL 325
ATCKL
Sbjct: 301 ATCKL 305
>gi|56202566|emb|CAI23161.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase
(hydroxymethylglutaricaciduria) [Homo sapiens]
gi|119615501|gb|EAW95095.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase
(hydroxymethylglutaricaciduria), isoform CRA_b [Homo
sapiens]
Length = 300
Score = 557 bits (1435), Expect = e-157, Method: Composition-based stats.
Identities = 286/300 (95%), Positives = 286/300 (95%)
Query: 26 MGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQM 85
MGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQM
Sbjct: 1 MGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQM 60
Query: 86 GDHTEVLKGIQKFPGINYPVLTPNLXXXXXXXXXXXXXXVIFGAASELFTKKNINCSIEE 145
GDHTEVLKGIQKFPGINYPVLTPNL VIFGAASELFTKKNINCSIEE
Sbjct: 61 GDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNINCSIEE 120
Query: 146 SFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLGDT 205
SFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLGDT
Sbjct: 121 SFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLGDT 180
Query: 206 IGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGG 265
IGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGG
Sbjct: 181 IGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGG 240
Query: 266 CPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQATCKL 325
CPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQATCKL
Sbjct: 241 CPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQATCKL 300
>gi|114554642|ref|XP_001166216.1| PREDICTED: similar to 3-hydroxymethyl-3-methylglutaryl-Coenzyme A
lyase (hydroxymethylglutaricaciduria) isoform 2 [Pan
troglodytes]
Length = 300
Score = 556 bits (1433), Expect = e-157, Method: Composition-based stats.
Identities = 285/300 (95%), Positives = 286/300 (95%)
Query: 26 MGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQM 85
MGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKL+DMLSEAGLSVIETTSFVSPKWVPQM
Sbjct: 1 MGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLVDMLSEAGLSVIETTSFVSPKWVPQM 60
Query: 86 GDHTEVLKGIQKFPGINYPVLTPNLXXXXXXXXXXXXXXVIFGAASELFTKKNINCSIEE 145
GDHTEVLKGIQKFPGINYPVLTPNL VIFGAASELFTKKNINCSIEE
Sbjct: 61 GDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNINCSIEE 120
Query: 146 SFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLGDT 205
SFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLGDT
Sbjct: 121 SFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLGDT 180
Query: 206 IGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGG 265
IGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGG
Sbjct: 181 IGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGG 240
Query: 266 CPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQATCKL 325
CPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQATCKL
Sbjct: 241 CPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQATCKL 300
>gi|83754896|pdb|2CW6|A Chain A, Crystal Structure Of Human Hmg-Coa Lyase: Insights Into
Catalysis And The Molecular Basis For
Hydroxymethylglutaric Aciduria
gi|83754897|pdb|2CW6|B Chain B, Crystal Structure Of Human Hmg-Coa Lyase: Insights Into
Catalysis And The Molecular Basis For
Hydroxymethylglutaric Aciduria
gi|83754898|pdb|2CW6|C Chain C, Crystal Structure Of Human Hmg-Coa Lyase: Insights Into
Catalysis And The Molecular Basis For
Hydroxymethylglutaric Aciduria
gi|83754899|pdb|2CW6|D Chain D, Crystal Structure Of Human Hmg-Coa Lyase: Insights Into
Catalysis And The Molecular Basis For
Hydroxymethylglutaric Aciduria
gi|83754900|pdb|2CW6|E Chain E, Crystal Structure Of Human Hmg-Coa Lyase: Insights Into
Catalysis And The Molecular Basis For
Hydroxymethylglutaric Aciduria
gi|83754901|pdb|2CW6|F Chain F, Crystal Structure Of Human Hmg-Coa Lyase: Insights Into
Catalysis And The Molecular Basis For
Hydroxymethylglutaric Aciduria
Length = 298
Score = 553 bits (1425), Expect = e-156, Method: Composition-based stats.
Identities = 284/298 (95%), Positives = 284/298 (95%)
Query: 28 TLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQMGD 87
TLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQMGD
Sbjct: 1 TLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQMGD 60
Query: 88 HTEVLKGIQKFPGINYPVLTPNLXXXXXXXXXXXXXXVIFGAASELFTKKNINCSIEESF 147
HTEVLKGIQKFPGINYPVLTPNL VIFGAASELFTKKNINCSIEESF
Sbjct: 61 HTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNINCSIEESF 120
Query: 148 QRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLGDTIG 207
QRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLGDTIG
Sbjct: 121 QRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLGDTIG 180
Query: 208 VGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGGCP 267
VGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGGCP
Sbjct: 181 VGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGGCP 240
Query: 268 YAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQATCKL 325
YAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQATCKL
Sbjct: 241 YAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQATCKL 298
>gi|13242293|ref|NP_077362.1| 3-hydroxy-3-methylglutaryl-Coenzyme A lyase [Rattus norvegicus]
gi|2495261|sp|P97519|HMGCL_RAT Hydroxymethylglutaryl-CoA lyase, mitochondrial precursor (HMG-CoA
lyase) (HL) (3-hydroxy-3-methylglutarate-CoA lyase)
gi|1743378|emb|CAA71148.1| 3-hydroxy-3-methylglutaryl CoA lyase [Rattus norvegicus]
gi|38511566|gb|AAH61797.1| 3-hydroxy-3-methylglutaryl-Coenzyme A lyase [Rattus norvegicus]
gi|149024282|gb|EDL80779.1| 3-hydroxy-3-methylglutaryl-Coenzyme A lyase, isoform CRA_a [Rattus
norvegicus]
Length = 325
Score = 546 bits (1408), Expect = e-154, Method: Composition-based stats.
Identities = 276/325 (84%), Positives = 298/325 (91%)
Query: 1 MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
MA +RKA P+RLVGLASLRA STSSMGTLPKRVKIVEVGPRDGLQNEK+IV TPVKIKLI
Sbjct: 1 MATVRKAFPQRLVGLASLRAASTSSMGTLPKRVKIVEVGPRDGLQNEKSIVPTPVKIKLI 60
Query: 61 DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLXXXXXXXXXX 120
DMLSEAGL VIE TSFVSPKWVPQM DH++VLKGIQKFPGINYPVLTPN+
Sbjct: 61 DMLSEAGLPVIEATSFVSPKWVPQMADHSDVLKGIQKFPGINYPVLTPNMKGFEEAVAAG 120
Query: 121 XXXXVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
IFGAASELFT+KN+NCSIEESFQRFD +++AA++A+ISVRGYVSCALGCPYEGK+
Sbjct: 121 AKEVSIFGAASELFTRKNVNCSIEESFQRFDGVMQAARAASISVRGYVSCALGCPYEGKV 180
Query: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
SPAKVAEV KK YSMGCYEISLGDTIGVGTPG+MKDML+AV+ EVP+AALAVHCHDTYGQ
Sbjct: 181 SPAKVAEVAKKLYSMGCYEISLGDTIGVGTPGLMKDMLTAVLHEVPVAALAVHCHDTYGQ 240
Query: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
ALANTL+ALQMGVSVVDSSVAGLGGCPYA+GASGNLATEDLVYML GLGIHTGVNLQKLL
Sbjct: 241 ALANTLVALQMGVSVVDSSVAGLGGCPYAKGASGNLATEDLVYMLTGLGIHTGVNLQKLL 300
Query: 301 EAGNFICQALNRKTSSKVAQATCKL 325
EAG+FICQALNRKTSSKVAQATCKL
Sbjct: 301 EAGDFICQALNRKTSSKVAQATCKL 325
>gi|149694251|ref|XP_001504254.1| PREDICTED: similar to interleukin 13 receptor alpha 1-binding
protein-1 [Equus caballus]
Length = 325
Score = 545 bits (1404), Expect = e-153, Method: Composition-based stats.
Identities = 283/325 (87%), Positives = 292/325 (89%)
Query: 1 MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
MA +RK LPRRL GLASLRAVSTSS+GT PKRVKIVEVGPRDGLQNEKNIV T +KIKLI
Sbjct: 1 MATVRKGLPRRLAGLASLRAVSTSSVGTFPKRVKIVEVGPRDGLQNEKNIVPTAMKIKLI 60
Query: 61 DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLXXXXXXXXXX 120
DMLSEAGL VIE TSFVSPKWVPQM DHTEVLKGIQKFPGINYPVLTPN
Sbjct: 61 DMLSEAGLPVIEATSFVSPKWVPQMADHTEVLKGIQKFPGINYPVLTPNFKGFQAAVAAG 120
Query: 121 XXXXVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
+FGAASELFTKKNINCSIEES QRF +LKAA++A+I VRGYVSCALGCPYEGKI
Sbjct: 121 AKEVAVFGAASELFTKKNINCSIEESIQRFGEVLKAARAASIPVRGYVSCALGCPYEGKI 180
Query: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
SPAKVAEVTKK YSMGCYEISLGDTIGVGTPG MKDMLSAVMQEVP+AALAVHCHDTYGQ
Sbjct: 181 SPAKVAEVTKKMYSMGCYEISLGDTIGVGTPGGMKDMLSAVMQEVPVAALAVHCHDTYGQ 240
Query: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYML GLGIHTGVNLQKLL
Sbjct: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLAGLGIHTGVNLQKLL 300
Query: 301 EAGNFICQALNRKTSSKVAQATCKL 325
EAG FICQALNRKTSSKVAQATCKL
Sbjct: 301 EAGTFICQALNRKTSSKVAQATCKL 325
>gi|115495073|ref|NP_001068600.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase
(hydroxymethylglutaricaciduria) [Bos taurus]
gi|116242512|sp|Q29448|HMGCL_BOVIN Hydroxymethylglutaryl-CoA lyase, mitochondrial precursor (HMG-CoA
lyase) (HL) (3-hydroxy-3-methylglutarate-CoA lyase)
gi|109939905|gb|AAI18277.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase
(hydroxymethylglutaricaciduria) [Bos taurus]
Length = 325
Score = 541 bits (1393), Expect = e-152, Method: Composition-based stats.
Identities = 276/325 (84%), Positives = 291/325 (89%)
Query: 1 MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
MA ++K LPRRLVGLA+LRAVSTSS+GT PK+VKIVEVGPRDGLQNEKNIV TPVKIKLI
Sbjct: 1 MATVKKVLPRRLVGLATLRAVSTSSVGTFPKQVKIVEVGPRDGLQNEKNIVPTPVKIKLI 60
Query: 61 DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLXXXXXXXXXX 120
DMLSEAGL V+E TSFVSPKWVPQM DH EVLKGIQKFPG+NYPVLTPN
Sbjct: 61 DMLSEAGLPVVEATSFVSPKWVPQMADHAEVLKGIQKFPGVNYPVLTPNFKGFQAAVAAG 120
Query: 121 XXXXVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
IFGAASELFTKKNINCSI+ES QRFD ILKAA++A ISVRGYVSC LGCPYEGKI
Sbjct: 121 AKEVAIFGAASELFTKKNINCSIDESLQRFDEILKAARAAGISVRGYVSCVLGCPYEGKI 180
Query: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
SPAKVAEVTKK YSMGCYEISLGDTIGVGTPG MKDMLSAV+QEVP+ ALAVHCHDTYGQ
Sbjct: 181 SPAKVAEVTKKLYSMGCYEISLGDTIGVGTPGAMKDMLSAVLQEVPVTALAVHCHDTYGQ 240
Query: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
ALANTL ALQMGVSV+DSSVAGLGGCPYAQGASGNLATEDLVYML GLGIHTGVNLQKLL
Sbjct: 241 ALANTLTALQMGVSVMDSSVAGLGGCPYAQGASGNLATEDLVYMLAGLGIHTGVNLQKLL 300
Query: 301 EAGNFICQALNRKTSSKVAQATCKL 325
EAG FICQALNR+T+SKVAQATCKL
Sbjct: 301 EAGAFICQALNRRTNSKVAQATCKL 325
>gi|19343556|gb|AAH25440.1| Hmgcl protein [Mus musculus]
gi|74180317|dbj|BAE32329.1| unnamed protein product [Mus musculus]
gi|74204922|dbj|BAE20956.1| unnamed protein product [Mus musculus]
gi|74208228|dbj|BAE26328.1| unnamed protein product [Mus musculus]
gi|123122205|emb|CAM15901.1| 3-hydroxy-3-methylglutaryl-Coenzyme A lyase [Mus musculus]
gi|148698016|gb|EDL29963.1| 3-hydroxy-3-methylglutaryl-Coenzyme A lyase [Mus musculus]
Length = 325
Score = 540 bits (1392), Expect = e-152, Method: Composition-based stats.
Identities = 273/325 (84%), Positives = 295/325 (90%)
Query: 1 MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
MA++RKA PRRLVGL SLRAVSTSSMGTLPK+VKIVEVGPRDGLQNEK+IV TPVKI+LI
Sbjct: 1 MASVRKAFPRRLVGLTSLRAVSTSSMGTLPKQVKIVEVGPRDGLQNEKSIVPTPVKIRLI 60
Query: 61 DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLXXXXXXXXXX 120
DMLSEAGL VIE TSFVSPKWVPQM DH++VLKGIQKFPGINYPVLTPN+
Sbjct: 61 DMLSEAGLPVIEATSFVSPKWVPQMADHSDVLKGIQKFPGINYPVLTPNMKGFEEAVAAG 120
Query: 121 XXXXVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
+FGA SELFT+KN NCSIEESFQRF +++AAQ+A+ISVRGYVSCALGCPYEGK+
Sbjct: 121 AKEVSVFGAVSELFTRKNANCSIEESFQRFAGVMQAAQAASISVRGYVSCALGCPYEGKV 180
Query: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
SPAKVAEV KK YSMGCYEISLGDTIGVGTPG+MKDML+AVM EVP+ ALAVHCHDTYGQ
Sbjct: 181 SPAKVAEVAKKLYSMGCYEISLGDTIGVGTPGLMKDMLTAVMHEVPVTALAVHCHDTYGQ 240
Query: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
ALANTL+ALQMGVSVVDSSVAGLGGCPYA+GASGNLATEDLVYML GLGIHTGVNLQKLL
Sbjct: 241 ALANTLVALQMGVSVVDSSVAGLGGCPYAKGASGNLATEDLVYMLNGLGIHTGVNLQKLL 300
Query: 301 EAGNFICQALNRKTSSKVAQATCKL 325
EAG+FICQALNRKTSSKVAQATCKL
Sbjct: 301 EAGDFICQALNRKTSSKVAQATCKL 325
>gi|6680233|ref|NP_032280.1| 3-hydroxy-3-methylglutaryl-Coenzyme A lyase [Mus musculus]
gi|1292952|gb|AAB03107.1| 3-hydroxy-3-methylglutaryl-CoA lyase
Length = 325
Score = 538 bits (1385), Expect = e-151, Method: Composition-based stats.
Identities = 271/325 (83%), Positives = 295/325 (90%)
Query: 1 MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
MA++RKA PRRLVGL SLRAVSTSSMGTLPK+VKIVEVGPRDGLQNEK+IV TPVKI+LI
Sbjct: 1 MASVRKAFPRRLVGLTSLRAVSTSSMGTLPKQVKIVEVGPRDGLQNEKSIVPTPVKIRLI 60
Query: 61 DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLXXXXXXXXXX 120
D++SEAGL VIE TSFVSPKWVPQM DH++VLKGIQKFPGINYPVLTPN+
Sbjct: 61 DIVSEAGLPVIEATSFVSPKWVPQMADHSDVLKGIQKFPGINYPVLTPNMKGFEEAVAAG 120
Query: 121 XXXXVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
+FGA SELFT+KN NCSIEESFQRF +++AAQ+A+ISVRGYVSCALGCPYEGK+
Sbjct: 121 AKEVSVFGAVSELFTRKNANCSIEESFQRFAGVMQAAQAASISVRGYVSCALGCPYEGKV 180
Query: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
SPAKVAEV KK YSMGCYEISLGDTIGVGTPG+MKDML+AVM EVP+ ALAVHCHDTYGQ
Sbjct: 181 SPAKVAEVAKKLYSMGCYEISLGDTIGVGTPGLMKDMLTAVMHEVPVTALAVHCHDTYGQ 240
Query: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
ALANTL+ALQMGVSVVDSSVAGLGGCPYA+GASGNLATEDLVYML GLGIHTGVNLQKLL
Sbjct: 241 ALANTLVALQMGVSVVDSSVAGLGGCPYAKGASGNLATEDLVYMLNGLGIHTGVNLQKLL 300
Query: 301 EAGNFICQALNRKTSSKVAQATCKL 325
EAG+FICQALNRKTSSKVAQATCKL
Sbjct: 301 EAGDFICQALNRKTSSKVAQATCKL 325
>gi|74194970|dbj|BAE26056.1| unnamed protein product [Mus musculus]
Length = 325
Score = 536 bits (1380), Expect = e-150, Method: Composition-based stats.
Identities = 271/325 (83%), Positives = 293/325 (90%)
Query: 1 MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
MA++RKA PRRLVGL SLRAVSTSSMGTLPK+VKIVEVGPRDGLQNEK+IV TPVKI+LI
Sbjct: 1 MASVRKAFPRRLVGLTSLRAVSTSSMGTLPKQVKIVEVGPRDGLQNEKSIVPTPVKIRLI 60
Query: 61 DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLXXXXXXXXXX 120
DMLSEAGL VIE TSFVSPKWVPQM DH++VLKGIQKFPGINYPVLTPN+
Sbjct: 61 DMLSEAGLPVIEATSFVSPKWVPQMADHSDVLKGIQKFPGINYPVLTPNMKGFEEAVAAG 120
Query: 121 XXXXVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
+FGA SELFT+KN NCSIEESFQRF +++AAQ+A+ISVRGYVSCALGCPYEGK+
Sbjct: 121 AKEVSVFGAVSELFTRKNANCSIEESFQRFAGVMQAAQAASISVRGYVSCALGCPYEGKV 180
Query: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
SPAKVAEV KK YSMGCYEISLGDTIGVGTP MKDML+AVM EVP+ ALAVHCHDTYGQ
Sbjct: 181 SPAKVAEVAKKLYSMGCYEISLGDTIGVGTPDXMKDMLTAVMHEVPVTALAVHCHDTYGQ 240
Query: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
ALANTL+ALQMGVSVV+SSVAGLGGCPYA+GASGNLATEDLVYML GLGIHTGVNLQKLL
Sbjct: 241 ALANTLVALQMGVSVVNSSVAGLGGCPYAKGASGNLATEDLVYMLNGLGIHTGVNLQKLL 300
Query: 301 EAGNFICQALNRKTSSKVAQATCKL 325
EAG+FICQALNRKTSSKVAQATCKL
Sbjct: 301 EAGDFICQALNRKTSSKVAQATCKL 325
>gi|585257|sp|P38060|HMGCL_MOUSE Hydroxymethylglutaryl-CoA lyase, mitochondrial precursor (HMG-CoA
lyase) (HL) (3-hydroxy-3-methylglutarate-CoA lyase)
gi|2143427|pir||I57009 3-Hydroxy-3-methylglutaryl coenzyme A lyase - mouse
gi|409499|gb|AAB27965.1| 3-Hydroxy-3-methylglutaryl coenzyme A lyase; HL [Mus sp.]
Length = 325
Score = 534 bits (1375), Expect = e-150, Method: Composition-based stats.
Identities = 270/325 (83%), Positives = 292/325 (89%)
Query: 1 MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
MA++RKA PRRLVGL SLRAVSTSSMGTLPK+VKIVEVGPRDGLQNEK+IV TPVKI+LI
Sbjct: 1 MASVRKAFPRRLVGLTSLRAVSTSSMGTLPKQVKIVEVGPRDGLQNEKSIVPTPVKIRLI 60
Query: 61 DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLXXXXXXXXXX 120
DMLSEAGL VIE TSFVSP WVPQM DH++VLKGIQKFPGINYPVLTPN+
Sbjct: 61 DMLSEAGLPVIEATSFVSPNWVPQMADHSDVLKGIQKFPGINYPVLTPNMKGFEEAVAAG 120
Query: 121 XXXXVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
+FGA SELFT+KN NCSIEESFQRF +++AAQ+A+ISVRGYVSCALGCPYEGK+
Sbjct: 121 AKEVSVFGAVSELFTRKNANCSIEESFQRFAGVMQAAQAASISVRGYVSCALGCPYEGKV 180
Query: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
SPAKVAEV KK YSMGCYEISLGDTIGVGTPG+MKDML+AVM EVP+ AL VHCHDT GQ
Sbjct: 181 SPAKVAEVAKKLYSMGCYEISLGDTIGVGTPGLMKDMLTAVMHEVPVTALGVHCHDTIGQ 240
Query: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
ALANTL+ALQMGVSVVDSSVAGLGGCPYA+GASGNLATEDLVYML GLGIHTGVNLQKLL
Sbjct: 241 ALANTLVALQMGVSVVDSSVAGLGGCPYAKGASGNLATEDLVYMLNGLGIHTGVNLQKLL 300
Query: 301 EAGNFICQALNRKTSSKVAQATCKL 325
EAG+FICQALNRKTSSKVAQATCKL
Sbjct: 301 EAGDFICQALNRKTSSKVAQATCKL 325
>gi|108999140|ref|XP_001104722.1| PREDICTED: 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase
(hydroxymethylglutaricaciduria) [Macaca mulatta]
Length = 331
Score = 531 bits (1368), Expect = e-149, Method: Composition-based stats.
Identities = 286/331 (86%), Positives = 288/331 (87%), Gaps = 6/331 (1%)
Query: 1 MAAMRKALPRRLVGLASLRAVSTSS------MGTLPKRVKIVEVGPRDGLQNEKNIVSTP 54
MAAM KALPRRLVGLASLRAVS S GTL RV + V P GL+ NIVSTP
Sbjct: 1 MAAMTKALPRRLVGLASLRAVSAPSRRGGGPAGTLTVRVGSLAVPPEWGLRFLTNIVSTP 60
Query: 55 VKIKLIDMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLXXXX 114
VKIKLIDMLSEAGLSVIE TSFVSPKWVPQM DH EVLKGIQKFPGI YPVL PNL
Sbjct: 61 VKIKLIDMLSEAGLSVIEATSFVSPKWVPQMADHAEVLKGIQKFPGITYPVLIPNLKGFE 120
Query: 115 XXXXXXXXXXVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGC 174
IFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSC LGC
Sbjct: 121 AAVAAGAKEVSIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCVLGC 180
Query: 175 PYEGKISPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHC 234
PYEGKISPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVP AALAVHC
Sbjct: 181 PYEGKISPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPPAALAVHC 240
Query: 235 HDTYGQALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGV 294
HDTYGQALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGV
Sbjct: 241 HDTYGQALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGV 300
Query: 295 NLQKLLEAGNFICQALNRKTSSKVAQATCKL 325
NLQKLLEAGNFICQALNRKTSSKVAQATCKL
Sbjct: 301 NLQKLLEAGNFICQALNRKTSSKVAQATCKL 331
>gi|114554644|ref|XP_001166145.1| PREDICTED: similar to 3-hydroxymethyl-3-methylglutaryl-Coenzyme A
lyase (hydroxymethylglutaricaciduria) isoform 1 [Pan
troglodytes]
Length = 293
Score = 528 bits (1359), Expect = e-148, Method: Composition-based stats.
Identities = 284/325 (87%), Positives = 286/325 (88%), Gaps = 32/325 (9%)
Query: 1 MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKL+
Sbjct: 1 MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLV 60
Query: 61 DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLXXXXXXXXXX 120
DMLSEAGLSVIETTSFVSPKWVPQ+
Sbjct: 61 DMLSEAGLSVIETTSFVSPKWVPQVA--------------------------------AG 88
Query: 121 XXXXVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
VIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI
Sbjct: 89 AKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 148
Query: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ
Sbjct: 149 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 208
Query: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL
Sbjct: 209 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 268
Query: 301 EAGNFICQALNRKTSSKVAQATCKL 325
EAGNFICQALNRKTSSKVAQATCKL
Sbjct: 269 EAGNFICQALNRKTSSKVAQATCKL 293
>gi|73950222|ref|XP_535360.2| PREDICTED: similar to Hydroxymethylglutaryl-CoA lyase,
mitochondrial precursor (HMG-CoA lyase) (HL)
(3-hydroxy-3-methylglutarate-CoA lyase) isoform 1 [Canis
familiaris]
Length = 325
Score = 522 bits (1344), Expect = e-146, Method: Composition-based stats.
Identities = 270/325 (83%), Positives = 281/325 (86%)
Query: 1 MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
MAAMRK +PRRLVGLASLRAVST S+GT PK+VKIVEVG RDGLQNEKNIVST KIKLI
Sbjct: 1 MAAMRKVVPRRLVGLASLRAVSTFSLGTFPKQVKIVEVGARDGLQNEKNIVSTSTKIKLI 60
Query: 61 DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLXXXXXXXXXX 120
DMLSEAGL VIE TSFVSPKWVPQM D EVLKGIQKFPGINYPVLTPN+
Sbjct: 61 DMLSEAGLPVIEATSFVSPKWVPQMADCAEVLKGIQKFPGINYPVLTPNIKGFQAAVAAG 120
Query: 121 XXXXVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
IF AASE FTKKN NCSI+E QR D I +AAQ+A I VRGYVSC LGCPYEGKI
Sbjct: 121 AKEVTIFAAASEQFTKKNTNCSIDECLQRSDDIFRAAQAAGIPVRGYVSCVLGCPYEGKI 180
Query: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
SPAKV EV KK YSMGCYEISLGDTIGVGTPG+MKDMLSAVM EVP++ALAVHCHDTYGQ
Sbjct: 181 SPAKVVEVAKKIYSMGCYEISLGDTIGVGTPGVMKDMLSAVMHEVPVSALAVHCHDTYGQ 240
Query: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
ALANTLMALQMGVSVVDSSVAGLGGCPYA+GASGNLATEDLVYML GLGIHTGVNLQKLL
Sbjct: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYARGASGNLATEDLVYMLSGLGIHTGVNLQKLL 300
Query: 301 EAGNFICQALNRKTSSKVAQATCKL 325
EAG FICQALNRKTSSKVAQA CKL
Sbjct: 301 EAGTFICQALNRKTSSKVAQAACKL 325
>gi|50759896|ref|XP_417834.1| PREDICTED: similar to Hydroxymethylglutaryl-CoA lyase (HMG-CoA
lyase) (HL) (3-hydroxy-3-methylglutarate-CoA lyase)
[Gallus gallus]
Length = 319
Score = 473 bits (1216), Expect = e-131, Method: Composition-based stats.
Identities = 238/325 (73%), Positives = 274/325 (84%), Gaps = 6/325 (1%)
Query: 1 MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
MAA+R+ LPR V SLR VST++ P+RVK+VEVGPRDGLQNEK++V TPVKI+LI
Sbjct: 1 MAAVRRLLPRWAV---SLRPVSTAA---FPQRVKVVEVGPRDGLQNEKSVVPTPVKIRLI 54
Query: 61 DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLXXXXXXXXXX 120
DMLSE GL VIE TSFVSP+WVPQM DH EV++GI K PG++YPVLTPNL
Sbjct: 55 DMLSETGLPVIEATSFVSPRWVPQMADHAEVMQGINKLPGVSYPVLTPNLKGFQAAVAAG 114
Query: 121 XXXXVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
IFGAASELFTKKNINCSIEES +RF ++ AA++A+I VRGYVSC LGCPYEG I
Sbjct: 115 AKEVSIFGAASELFTKKNINCSIEESLERFSEVMNAARAASIPVRGYVSCVLGCPYEGNI 174
Query: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
S AKVAEV+KK YSMGCYEISLGDTIG+GTPG MK+ML+AVM+EVP+ ALAVHCHDTYGQ
Sbjct: 175 SAAKVAEVSKKMYSMGCYEISLGDTIGIGTPGSMKEMLAAVMKEVPVGALAVHCHDTYGQ 234
Query: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
ALAN L+ALQMGVSVVD+SVAGLGGCPYAQGASGN+ATEDLVYML GLGIHTGV+LQKL+
Sbjct: 235 ALANILVALQMGVSVVDASVAGLGGCPYAQGASGNVATEDLVYMLNGLGIHTGVDLQKLM 294
Query: 301 EAGNFICQALNRKTSSKVAQATCKL 325
+ G FIC ALNR+T+SKV+QA C+L
Sbjct: 295 DTGTFICNALNRRTNSKVSQAACRL 319
>gi|126328575|ref|XP_001363832.1| PREDICTED: similar to alpha-2-macroglobulin receptor [Monodelphis
domestica]
Length = 327
Score = 460 bits (1183), Expect = e-128, Method: Composition-based stats.
Identities = 239/313 (76%), Positives = 267/313 (85%)
Query: 9 PRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGL 68
P RL G +SLRA+S+SS+ PK+VKIVEVGPRDGLQNEK+I+ T +KIKLIDMLS AGL
Sbjct: 10 PLRLAGTSSLRAISSSSLDAFPKQVKIVEVGPRDGLQNEKHILPTQMKIKLIDMLSAAGL 69
Query: 69 SVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLXXXXXXXXXXXXXXVIFG 128
VIE TSFVSPKWVPQM DH EVL+GI+KFPGI+YPVLTPNL IFG
Sbjct: 70 PVIEATSFVSPKWVPQMADHAEVLQGIEKFPGISYPVLTPNLRGFQAAVAAGAKEVAIFG 129
Query: 129 AASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEV 188
AASELF+KKNINCSIEES+QRF+ +L A+ ANI VRGYVSC LGCPYEGK+SPAKVAEV
Sbjct: 130 AASELFSKKNINCSIEESYQRFEEVLTEARCANIPVRGYVSCVLGCPYEGKVSPAKVAEV 189
Query: 189 TKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMA 248
KK YSMGC+EISLGDTIGVGTP MK+MLSAVM+E+P++ALAVHCHDTYGQALAN LMA
Sbjct: 190 AKKLYSMGCFEISLGDTIGVGTPLGMKNMLSAVMKEMPVSALAVHCHDTYGQALANILMA 249
Query: 249 LQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQ 308
LQMGVSVVDSSVAGLGGCPY+ GASGN+ATEDL+YML GLGI TGVNLQKL +AG FIC+
Sbjct: 250 LQMGVSVVDSSVAGLGGCPYSPGASGNVATEDLLYMLNGLGIDTGVNLQKLTDAGKFICK 309
Query: 309 ALNRKTSSKVAQA 321
ALNRK SSKVA A
Sbjct: 310 ALNRKNSSKVATA 322
>gi|547653|sp|P35915|HMGCL_CHICK Hydroxymethylglutaryl-CoA lyase (HMG-CoA lyase) (HL)
(3-hydroxy-3-methylglutarate-CoA lyase)
Length = 298
Score = 456 bits (1173), Expect = e-127, Method: Composition-based stats.
Identities = 223/297 (75%), Positives = 255/297 (85%)
Query: 29 LPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQMGDH 88
P+RVK+VEVGPRDGLQNEK++V TPVKI+LIDMLSE GL VIE TSFVSP+WVPQM DH
Sbjct: 2 FPQRVKVVEVGPRDGLQNEKSVVPTPVKIRLIDMLSETGLPVIEATSFVSPRWVPQMADH 61
Query: 89 TEVLKGIQKFPGINYPVLTPNLXXXXXXXXXXXXXXVIFGAASELFTKKNINCSIEESFQ 148
EV++GI K PG++YPVLTPNL IFGAASELFTKKNINCSIEES +
Sbjct: 62 AEVMQGINKLPGVSYPVLTPNLKGFQAAVAAGAKEVSIFGAASELFTKKNINCSIEESLE 121
Query: 149 RFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLGDTIGV 208
RF ++ AA++A+I VRGYVSC LGCPYEG IS AKVAEV+KK YSMGCYEISLGD IG+
Sbjct: 122 RFSEVMNAARAASIPVRGYVSCVLGCPYEGNISAAKVAEVSKKMYSMGCYEISLGDRIGI 181
Query: 209 GTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGGCPY 268
GTPG MK+ML+AVM+EVP+ ALAVHCHDTYGQALAN L+ALQMGVSVVD+SVAGLGGCPY
Sbjct: 182 GTPGSMKEMLAAVMKEVPVGALAVHCHDTYGQALANILVALQMGVSVVDASVAGLGGCPY 241
Query: 269 AQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQATCKL 325
AQGASGN+ATEDLVYML GLGIHTGV+LQKL++ G FIC ALNR+T+SKV+QA C+L
Sbjct: 242 AQGASGNVATEDLVYMLNGLGIHTGVDLQKLMDTGTFICNALNRRTNSKVSQAACRL 298
>gi|41055014|ref|NP_957509.1| hypothetical protein LOC394190 [Danio rerio]
gi|28277949|gb|AAH46023.1| Zgc:56248 [Danio rerio]
Length = 340
Score = 448 bits (1152), Expect = e-124, Method: Composition-based stats.
Identities = 224/312 (71%), Positives = 262/312 (83%), Gaps = 2/312 (0%)
Query: 16 ASLRAVSTSSMGT--LPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIET 73
A +R+VS S+ + LP+RVKIVEVGPRDGLQNEK IV T VKI+LIDMLSEAGL VIE
Sbjct: 29 ALIRSVSVSAAASQALPERVKIVEVGPRDGLQNEKTIVPTEVKIRLIDMLSEAGLPVIEA 88
Query: 74 TSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLXXXXXXXXXXXXXXVIFGAASEL 133
TSFVSPKWVPQM D EV++G+ K PG+NYPVLTPNL IFGAASEL
Sbjct: 89 TSFVSPKWVPQMADQEEVMRGLHKKPGVNYPVLTPNLKGFQAAVKAGAKEVAIFGAASEL 148
Query: 134 FTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFY 193
F+KKNINCS+EES RF+ ++ AA+ +SVRGYVSC LGCPYEGK+SP+KVAEV K+ Y
Sbjct: 149 FSKKNINCSVEESLVRFEEVMTAAKQEGVSVRGYVSCVLGCPYEGKVSPSKVAEVAKRLY 208
Query: 194 SMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGV 253
SMGCYE+SLGDTIGVGTPG M +ML+AV +E+P+ ALAVHCHDTYGQALAN L+ALQ GV
Sbjct: 209 SMGCYEVSLGDTIGVGTPGGMTEMLNAVKKELPVEALAVHCHDTYGQALANILVALQNGV 268
Query: 254 SVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRK 313
SVVDSSVAGLGGCPYAQGASGN+ATED+VYML GLGIHTGV+L +LL+AG+FIC ++NR+
Sbjct: 269 SVVDSSVAGLGGCPYAQGASGNVATEDVVYMLHGLGIHTGVDLPRLLDAGSFICHSINRR 328
Query: 314 TSSKVAQATCKL 325
T+SKVAQA+CKL
Sbjct: 329 TNSKVAQASCKL 340