BLASTP 2.2.17 [Aug-26-2007]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Reference for composition-based statistics:
Schäffer, Alejandro A., L. Aravind, Thomas L. Madden, 
Schaffer, Alejandro A., L. Aravind, Thomas L. Madden,
Sergei Shavirin, John L. Spouge, Yuri I. Wolf,  
Eugene V. Koonin, and Stephen F. Altschul (2001), 
"Improving the accuracy of PSI-BLAST protein database searches with 
composition-based statistics and other refinements",  Nucleic Acids Res. 29:2994-3005.

Query= ENSG00000117305__[Homo_sapiens]
         (325 letters)

Database: nr.pal 
           6,348,806 sequences; 2,166,943,470 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|62198232|ref|NP_000182.2|  3-hydroxymethyl-3-methylglutar...   598   e-169
gi|114554638|ref|XP_001166273.1|  PREDICTED: 3-hydroxymethyl...   597   e-169
gi|184503|gb|AAA92733.1|  hydroxymethylglutaryl-CoA lyase [H...   597   e-169
gi|61213670|sp|Q5R9E1|HMGCL_PONPY  Hydroxymethylglutaryl-CoA...   588   e-166
gi|61213704|sp|Q8HXZ6|HMGCL_MACFA  Hydroxymethylglutaryl-CoA...   572   e-162
gi|90077136|dbj|BAE88248.1|  unnamed protein product [Macaca...   568   e-160
gi|114554640|ref|XP_513200.2|  PREDICTED: similar to 3-hydro...   564   e-159
gi|1292941|gb|AAB19099.1|  hydroxymethylglutaryl-CoA lyase        561   e-158
gi|56202566|emb|CAI23161.1|  3-hydroxymethyl-3-methylglutary...   557   e-157
gi|114554642|ref|XP_001166216.1|  PREDICTED: similar to 3-hy...   556   e-157
gi|83754896|pdb|2CW6|A  Chain A, Crystal Structure Of Human ...   553   e-156
gi|13242293|ref|NP_077362.1|  3-hydroxy-3-methylglutaryl-Coe...   546   e-154
gi|149694251|ref|XP_001504254.1|  PREDICTED: similar to inte...   545   e-153
gi|115495073|ref|NP_001068600.1|  3-hydroxymethyl-3-methylgl...   541   e-152
gi|19343556|gb|AAH25440.1|  Hmgcl protein [Mus musculus] >gi...   540   e-152
gi|6680233|ref|NP_032280.1|  3-hydroxy-3-methylglutaryl-Coen...   538   e-151
gi|74194970|dbj|BAE26056.1|  unnamed protein product [Mus mu...   536   e-150
gi|585257|sp|P38060|HMGCL_MOUSE  Hydroxymethylglutaryl-CoA l...   534   e-150
gi|108999140|ref|XP_001104722.1|  PREDICTED: 3-hydroxymethyl...   531   e-149
gi|114554644|ref|XP_001166145.1|  PREDICTED: similar to 3-hy...   528   e-148
gi|73950222|ref|XP_535360.2|  PREDICTED: similar to Hydroxym...   522   e-146
gi|50759896|ref|XP_417834.1|  PREDICTED: similar to Hydroxym...   473   e-131
gi|126328575|ref|XP_001363832.1|  PREDICTED: similar to alph...   460   e-128
gi|547653|sp|P35915|HMGCL_CHICK  Hydroxymethylglutaryl-CoA l...   456   e-127
gi|41055014|ref|NP_957509.1|  hypothetical protein LOC394190...   448   e-124
gi|211947|gb|AAA92728.1|  hydroxymethylglutaryl-CoA lyase         446   e-123
gi|148232581|ref|NP_001085152.1|  hypothetical protein LOC43...   444   e-123
gi|47219546|emb|CAG09900.1|  unnamed protein product [Tetrao...   440   e-122
gi|19526275|gb|AAL89669.1|AF411956_10  hydroxymethylglutaryl...   431   e-119
gi|73973416|ref|XP_538973.2|  PREDICTED: similar to 3-hydrox...   429   e-118
gi|109071671|ref|XP_001105003.1|  PREDICTED: similar to 3-hy...   427   e-118
gi|149732643|ref|XP_001499476.1|  PREDICTED: similar to 3-hy...   427   e-118
gi|109150427|ref|NP_061909.2|  3-hydroxymethyl-3-methylgluta...   427   e-118
gi|109150422|ref|NP_001035865.1|  3-hydroxymethyl-3-methylgl...   427   e-118
gi|50744846|ref|XP_419903.1|  PREDICTED: similar to 3-hydrox...   426   e-117
gi|126310275|ref|XP_001371535.1|  PREDICTED: similar to 3-hy...   420   e-116
gi|149019133|gb|EDL77774.1|  similar to 3-hydroxymethyl-3-me...   419   e-115
gi|33239379|ref|NP_776092.1|  3-hydroxymethyl-3-methylglutar...   418   e-115
gi|119915033|ref|XP_615612.3|  PREDICTED: similar to 3-hydro...   416   e-114
gi|62653916|ref|XP_345954.2|  PREDICTED: similar to 3-hydrox...   415   e-114
gi|119915031|ref|XP_001252308.1|  PREDICTED: similar to 3-hy...   414   e-114
gi|160333724|ref|NP_001103870.1|  hypothetical protein LOC57...   412   e-113
gi|115749044|ref|XP_001196745.1|  PREDICTED: similar to MGC8...   393   e-108
gi|156399405|ref|XP_001638492.1|  predicted protein [Nematos...   373   e-102
gi|158293482|ref|XP_314824.4|  AGAP008717-PA [Anopheles gamb...   369   e-100
gi|157126265|ref|XP_001654565.1|  hydroxymethylglutaryl-coa ...   369   e-100
gi|125984033|ref|XP_001355781.1|  GA10298-PA [Drosophila pse...   367   e-100
gi|84453198|dbj|BAE71196.1|  putative hydroxymethylglutaryl-...   365   2e-99
gi|170031762|ref|XP_001843753.1|  hydroxymethylglutaryl-CoA ...   364   4e-99
gi|125525336|gb|EAY73450.1|  hypothetical protein OsI_001297...   363   1e-98
gi|125569854|gb|EAZ11369.1|  hypothetical protein OsJ_001194...   363   1e-98
gi|108862158|gb|ABA95738.2|  Hydroxymethylglutaryl-CoA lyase...   362   2e-98
gi|18401240|ref|NP_565629.1|  hydroxymethylglutaryl-CoA lyas...   361   4e-98
gi|157343219|emb|CAO67270.1|  unnamed protein product [Vitis...   360   6e-98
gi|66772937|gb|AAY55779.1|  IP10508p [Drosophila melanogaster]    360   1e-97
gi|115484067|ref|NP_001065695.1|  Os11g0137200 [Oryza sativa...   359   1e-97
gi|24582381|ref|NP_609089.1|  CG10399 CG10399-PA [Drosophila...   359   1e-97
gi|115487212|ref|NP_001066093.1|  Os12g0134000 [Oryza sativa...   358   4e-97
gi|167533391|ref|XP_001748375.1|  predicted protein [Monosig...   357   5e-97
gi|168030137|ref|XP_001767580.1|  predicted protein [Physcom...   357   6e-97
gi|30683260|ref|NP_850087.1|  hydroxymethylglutaryl-CoA lyas...   357   7e-97
gi|144899161|emb|CAM76025.1|  Pyruvate carboxyltransferase [...   355   3e-96
gi|56783756|dbj|BAD81168.1|  putative hydroxymethylglutaryl-...   355   3e-96
gi|23016672|ref|ZP_00056425.1|  COG0119: Isopropylmalate/hom...   354   4e-96
gi|115435876|ref|NP_001042696.1|  Os01g0269000 [Oryza sativa...   354   4e-96
gi|66810321|ref|XP_638884.1|  hydroxymethylglutaryl-CoA lyas...   354   6e-96
gi|149911150|ref|ZP_01899775.1|  Hydroxymethylglutaryl-CoA l...   352   2e-95
gi|71905728|ref|YP_283315.1|  Pyruvate carboxyltransferase [...   351   4e-95
gi|88813679|ref|ZP_01128907.1|  Pyruvate carboxyltransferase...   350   7e-95
gi|163750398|ref|ZP_02157638.1|  hydroxymethylglutaryl-CoA l...   350   8e-95
gi|157347577|emb|CAO18214.1|  unnamed protein product [Vitis...   350   8e-95
gi|124360527|gb|ABN08537.1|  Pyruvate carboxyltransferase [M...   348   2e-94
gi|87120147|ref|ZP_01076043.1|  3-hydroxymethylglutaryl-CoA ...   348   3e-94
gi|157962622|ref|YP_001502656.1|  pyruvate carboxyltransfera...   347   5e-94
gi|146307057|ref|YP_001187522.1|  hydroxymethylglutaryl-CoA ...   346   1e-93
gi|83309772|ref|YP_420036.1|  Isopropylmalate/homocitrate/ci...   346   1e-93
gi|71280227|ref|YP_268341.1|  hydroxymethylglutaryl-CoA lyas...   345   2e-93
gi|109899236|ref|YP_662491.1|  pyruvate carboxyltransferase ...   345   3e-93
gi|157374593|ref|YP_001473193.1|  pyruvate carboxyltransfera...   344   5e-93
gi|94502147|ref|ZP_01308647.1|  hydroxymethylglutaryl-CoA ly...   344   6e-93
gi|84326699|ref|ZP_00974724.1|  COG0119: Isopropylmalate/hom...   343   8e-93
gi|167624821|ref|YP_001675115.1|  pyruvate carboxyltransfera...   343   1e-92
gi|127513502|ref|YP_001094699.1|  pyruvate carboxyltransfera...   343   1e-92
gi|168038042|ref|XP_001771511.1|  predicted protein [Physcom...   342   2e-92
gi|108755216|emb|CAK32536.1|  Hydroxymethylglutaryl-CoA lyas...   340   6e-92
gi|57209295|emb|CAI40662.1|  novel protein similar to 3-hydr...   340   6e-92
gi|120555041|ref|YP_959392.1|  pyruvate carboxyltransferase ...   340   8e-92
gi|146283542|ref|YP_001173695.1|  hydroxymethylglutaryl-CoA ...   340   8e-92
gi|77165359|ref|YP_343884.1|  Pyruvate carboxyltransferase [...   340   9e-92
gi|170727566|ref|YP_001761592.1|  pyruvate carboxyltransfera...   340   1e-91
gi|119774495|ref|YP_927235.1|  pyruvate carboxyltransferase ...   340   1e-91
gi|67155614|ref|ZP_00417242.1|  HMG-CoA lyase-like [Azotobac...   339   1e-91
gi|89092352|ref|ZP_01165306.1|  Pyruvate carboxyltransferase...   338   2e-91
gi|149377182|ref|ZP_01894930.1|  3-hydroxymethylglutaryl-CoA...   338   3e-91
gi|119477419|ref|ZP_01617610.1|  hydroxymethylglutaryl-CoA l...   338   3e-91
gi|145480821|ref|XP_001426433.1|  hypothetical protein GSPAT...   338   4e-91
gi|126667844|ref|ZP_01738810.1|  3-hydroxymethylglutaryl-CoA...   337   5e-91
gi|118384118|ref|XP_001025212.1|  HMGL-like family protein [...   336   1e-90
gi|56478076|ref|YP_159665.1|  3-hydroxymethylglutaryl-CoA or...   335   2e-90
gi|119615503|gb|EAW95097.1|  3-hydroxymethyl-3-methylglutary...   335   2e-90
>gi|62198232|ref|NP_000182.2| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase
           (hydroxymethylglutaricaciduria) [Homo sapiens]
 gi|24418852|sp|P35914|HMGCL_HUMAN Hydroxymethylglutaryl-CoA lyase, mitochondrial precursor (HMG-CoA
           lyase) (HL) (3-hydroxy-3-methylglutarate-CoA lyase)
 gi|14714839|gb|AAH10570.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase
           (hydroxymethylglutaricaciduria) [Homo sapiens]
 gi|32879927|gb|AAP88794.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase
           (hydroxymethylglutaricaciduria) [Homo sapiens]
 gi|48145885|emb|CAG33165.1| HMGCL [Homo sapiens]
 gi|60654783|gb|AAX31956.1| 3-hydroxymethyl-3-methylglutaryl-coenzyme A lyase [synthetic
           construct]
 gi|60654785|gb|AAX31957.1| 3-hydroxymethyl-3-methylglutaryl-coenzyme A lyase [synthetic
           construct]
 gi|60654787|gb|AAX31958.1| 3-hydroxymethyl-3-methylglutaryl-coenzyme A lyase [synthetic
           construct]
 gi|60654789|gb|AAX31959.1| 3-hydroxymethyl-3-methylglutaryl-coenzyme A lyase [synthetic
           construct]
 gi|119615500|gb|EAW95094.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase
           (hydroxymethylglutaricaciduria), isoform CRA_a [Homo
           sapiens]
 gi|123982536|gb|ABM83009.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase
           (hydroxymethylglutaricaciduria) [synthetic construct]
 gi|123997201|gb|ABM86202.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase
           (hydroxymethylglutaricaciduria) [synthetic construct]
          Length = 325

 Score =  598 bits (1543), Expect = e-169,   Method: Composition-based stats.
 Identities = 311/325 (95%), Positives = 311/325 (95%)

Query: 1   MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
           MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI
Sbjct: 1   MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60

Query: 61  DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLXXXXXXXXXX 120
           DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNL          
Sbjct: 61  DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAG 120

Query: 121 XXXXVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
               VIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI
Sbjct: 121 AKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180

Query: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
           SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ
Sbjct: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240

Query: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
           ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL
Sbjct: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300

Query: 301 EAGNFICQALNRKTSSKVAQATCKL 325
           EAGNFICQALNRKTSSKVAQATCKL
Sbjct: 301 EAGNFICQALNRKTSSKVAQATCKL 325
>gi|114554638|ref|XP_001166273.1| PREDICTED: 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase
           (hydroxymethylglutaricaciduria) isoform 3 [Pan
           troglodytes]
          Length = 325

 Score =  597 bits (1540), Expect = e-169,   Method: Composition-based stats.
 Identities = 310/325 (95%), Positives = 311/325 (95%)

Query: 1   MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
           MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKL+
Sbjct: 1   MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLV 60

Query: 61  DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLXXXXXXXXXX 120
           DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNL          
Sbjct: 61  DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAG 120

Query: 121 XXXXVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
               VIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI
Sbjct: 121 AKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180

Query: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
           SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ
Sbjct: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240

Query: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
           ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL
Sbjct: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300

Query: 301 EAGNFICQALNRKTSSKVAQATCKL 325
           EAGNFICQALNRKTSSKVAQATCKL
Sbjct: 301 EAGNFICQALNRKTSSKVAQATCKL 325
>gi|184503|gb|AAA92733.1| hydroxymethylglutaryl-CoA lyase [Homo sapiens]
          Length = 325

 Score =  597 bits (1539), Expect = e-169,   Method: Composition-based stats.
 Identities = 310/325 (95%), Positives = 310/325 (95%)

Query: 1   MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
           MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI
Sbjct: 1   MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60

Query: 61  DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLXXXXXXXXXX 120
           DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNL          
Sbjct: 61  DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAG 120

Query: 121 XXXXVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
               VIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI
Sbjct: 121 AKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180

Query: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
           SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ
Sbjct: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240

Query: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
           AL NTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL
Sbjct: 241 ALTNTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300

Query: 301 EAGNFICQALNRKTSSKVAQATCKL 325
           EAGNFICQALNRKTSSKVAQATCKL
Sbjct: 301 EAGNFICQALNRKTSSKVAQATCKL 325
>gi|61213670|sp|Q5R9E1|HMGCL_PONPY Hydroxymethylglutaryl-CoA lyase, mitochondrial precursor (HMG-CoA
           lyase) (HL) (3-hydroxy-3-methylglutarate-CoA lyase)
 gi|55729782|emb|CAH91619.1| hypothetical protein [Pongo pygmaeus]
          Length = 325

 Score =  588 bits (1516), Expect = e-166,   Method: Composition-based stats.
 Identities = 307/325 (94%), Positives = 308/325 (94%)

Query: 1   MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
           MAAMRKA+PRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI
Sbjct: 1   MAAMRKAVPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60

Query: 61  DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLXXXXXXXXXX 120
           DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNL          
Sbjct: 61  DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAG 120

Query: 121 XXXXVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
                IFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI
Sbjct: 121 AKEVAIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180

Query: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
           SPAKVAEVTKK YSMGCYEISLGDTIGVGTPGIMK MLSAVMQEVPLAALAVHCHDTYGQ
Sbjct: 181 SPAKVAEVTKKLYSMGCYEISLGDTIGVGTPGIMKGMLSAVMQEVPLAALAVHCHDTYGQ 240

Query: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
           ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL
Sbjct: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300

Query: 301 EAGNFICQALNRKTSSKVAQATCKL 325
           EAGNFICQALNRKTSSKVAQATCKL
Sbjct: 301 EAGNFICQALNRKTSSKVAQATCKL 325
>gi|61213704|sp|Q8HXZ6|HMGCL_MACFA Hydroxymethylglutaryl-CoA lyase, mitochondrial precursor (HMG-CoA
           lyase) (HL) (3-hydroxy-3-methylglutarate-CoA lyase)
 gi|23574743|dbj|BAC20595.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase [Macaca
           fascicularis]
          Length = 325

 Score =  572 bits (1475), Expect = e-162,   Method: Composition-based stats.
 Identities = 299/325 (92%), Positives = 301/325 (92%)

Query: 1   MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
           MAAM KALPRRLVGLASLRAVSTSSM TLPK+VKIVEVGPRDGLQNEKNIVSTPVKIKLI
Sbjct: 1   MAAMTKALPRRLVGLASLRAVSTSSMDTLPKQVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60

Query: 61  DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLXXXXXXXXXX 120
           DMLSEAGLSVIE TSFVSPKWVPQM DH EVLKGIQKFPGI YPVL PNL          
Sbjct: 61  DMLSEAGLSVIEATSFVSPKWVPQMADHAEVLKGIQKFPGITYPVLIPNLKGFEAAVAAG 120

Query: 121 XXXXVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
                IFGAASELFTKKN+NCSIEESFQRFDAILKAAQSANISVRGYVSC LGCPYEGKI
Sbjct: 121 AKEVSIFGAASELFTKKNVNCSIEESFQRFDAILKAAQSANISVRGYVSCVLGCPYEGKI 180

Query: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
           SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVP AALAVHCHDTYGQ
Sbjct: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPPAALAVHCHDTYGQ 240

Query: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
           ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL
Sbjct: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300

Query: 301 EAGNFICQALNRKTSSKVAQATCKL 325
           EAGNFICQALNRKTSSKVAQATCKL
Sbjct: 301 EAGNFICQALNRKTSSKVAQATCKL 325
>gi|90077136|dbj|BAE88248.1| unnamed protein product [Macaca fascicularis]
          Length = 325

 Score =  568 bits (1465), Expect = e-160,   Method: Composition-based stats.
 Identities = 298/325 (91%), Positives = 300/325 (92%)

Query: 1   MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
           MAAM KALPRRLVGLASLRAVSTSSM TLPK+VKIVEVGPRDGLQN+KNIVSTPVKIKLI
Sbjct: 1   MAAMTKALPRRLVGLASLRAVSTSSMDTLPKQVKIVEVGPRDGLQNKKNIVSTPVKIKLI 60

Query: 61  DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLXXXXXXXXXX 120
           DMLSEAGLSVIE TSFVSPKWVPQM DH EVLKGIQKFPGI YPVL PNL          
Sbjct: 61  DMLSEAGLSVIEATSFVSPKWVPQMADHAEVLKGIQKFPGITYPVLIPNLKGFEAAVAAG 120

Query: 121 XXXXVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
                IFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSC LGCPYEGKI
Sbjct: 121 AKEVSIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCVLGCPYEGKI 180

Query: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
           SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVP AALAVHCHDTYGQ
Sbjct: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPPAALAVHCHDTYGQ 240

Query: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
           ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQK L
Sbjct: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKPL 300

Query: 301 EAGNFICQALNRKTSSKVAQATCKL 325
           EAGNFICQALNRKTSSKVAQATCKL
Sbjct: 301 EAGNFICQALNRKTSSKVAQATCKL 325
>gi|114554640|ref|XP_513200.2| PREDICTED: similar to 3-hydroxymethyl-3-methylglutaryl-Coenzyme A
           lyase (hydroxymethylglutaricaciduria) isoform 4 [Pan
           troglodytes]
          Length = 316

 Score =  564 bits (1453), Expect = e-159,   Method: Composition-based stats.
 Identities = 290/305 (95%), Positives = 291/305 (95%)

Query: 21  VSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPK 80
           VSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKL+DMLSEAGLSVIETTSFVSPK
Sbjct: 12  VSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLVDMLSEAGLSVIETTSFVSPK 71

Query: 81  WVPQMGDHTEVLKGIQKFPGINYPVLTPNLXXXXXXXXXXXXXXVIFGAASELFTKKNIN 140
           WVPQMGDHTEVLKGIQKFPGINYPVLTPNL              VIFGAASELFTKKNIN
Sbjct: 72  WVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNIN 131

Query: 141 CSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEI 200
           CSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEI
Sbjct: 132 CSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEI 191

Query: 201 SLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSV 260
           SLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSV
Sbjct: 192 SLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSV 251

Query: 261 AGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQ 320
           AGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQ
Sbjct: 252 AGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQ 311

Query: 321 ATCKL 325
           ATCKL
Sbjct: 312 ATCKL 316
>gi|1292941|gb|AAB19099.1| hydroxymethylglutaryl-CoA lyase
          Length = 305

 Score =  561 bits (1445), Expect = e-158,   Method: Composition-based stats.
 Identities = 290/305 (95%), Positives = 291/305 (95%)

Query: 21  VSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPK 80
           VSTSSMGTLPKRVKIVEVGP+DGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPK
Sbjct: 1   VSTSSMGTLPKRVKIVEVGPQDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPK 60

Query: 81  WVPQMGDHTEVLKGIQKFPGINYPVLTPNLXXXXXXXXXXXXXXVIFGAASELFTKKNIN 140
           WVPQMGDHTEVLKGIQKFPGINYPVLTPNL              VIFGAASELFTKKNIN
Sbjct: 61  WVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNIN 120

Query: 141 CSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEI 200
           CSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEI
Sbjct: 121 CSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEI 180

Query: 201 SLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSV 260
           SLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSV
Sbjct: 181 SLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSV 240

Query: 261 AGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQ 320
           AGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQ
Sbjct: 241 AGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQ 300

Query: 321 ATCKL 325
           ATCKL
Sbjct: 301 ATCKL 305
>gi|56202566|emb|CAI23161.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase
           (hydroxymethylglutaricaciduria) [Homo sapiens]
 gi|119615501|gb|EAW95095.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase
           (hydroxymethylglutaricaciduria), isoform CRA_b [Homo
           sapiens]
          Length = 300

 Score =  557 bits (1435), Expect = e-157,   Method: Composition-based stats.
 Identities = 286/300 (95%), Positives = 286/300 (95%)

Query: 26  MGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQM 85
           MGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQM
Sbjct: 1   MGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQM 60

Query: 86  GDHTEVLKGIQKFPGINYPVLTPNLXXXXXXXXXXXXXXVIFGAASELFTKKNINCSIEE 145
           GDHTEVLKGIQKFPGINYPVLTPNL              VIFGAASELFTKKNINCSIEE
Sbjct: 61  GDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNINCSIEE 120

Query: 146 SFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLGDT 205
           SFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLGDT
Sbjct: 121 SFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLGDT 180

Query: 206 IGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGG 265
           IGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGG
Sbjct: 181 IGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGG 240

Query: 266 CPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQATCKL 325
           CPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQATCKL
Sbjct: 241 CPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQATCKL 300
>gi|114554642|ref|XP_001166216.1| PREDICTED: similar to 3-hydroxymethyl-3-methylglutaryl-Coenzyme A
           lyase (hydroxymethylglutaricaciduria) isoform 2 [Pan
           troglodytes]
          Length = 300

 Score =  556 bits (1433), Expect = e-157,   Method: Composition-based stats.
 Identities = 285/300 (95%), Positives = 286/300 (95%)

Query: 26  MGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQM 85
           MGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKL+DMLSEAGLSVIETTSFVSPKWVPQM
Sbjct: 1   MGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLVDMLSEAGLSVIETTSFVSPKWVPQM 60

Query: 86  GDHTEVLKGIQKFPGINYPVLTPNLXXXXXXXXXXXXXXVIFGAASELFTKKNINCSIEE 145
           GDHTEVLKGIQKFPGINYPVLTPNL              VIFGAASELFTKKNINCSIEE
Sbjct: 61  GDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNINCSIEE 120

Query: 146 SFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLGDT 205
           SFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLGDT
Sbjct: 121 SFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLGDT 180

Query: 206 IGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGG 265
           IGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGG
Sbjct: 181 IGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGG 240

Query: 266 CPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQATCKL 325
           CPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQATCKL
Sbjct: 241 CPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQATCKL 300
>gi|83754896|pdb|2CW6|A Chain A, Crystal Structure Of Human Hmg-Coa Lyase: Insights Into
           Catalysis And The Molecular Basis For
           Hydroxymethylglutaric Aciduria
 gi|83754897|pdb|2CW6|B Chain B, Crystal Structure Of Human Hmg-Coa Lyase: Insights Into
           Catalysis And The Molecular Basis For
           Hydroxymethylglutaric Aciduria
 gi|83754898|pdb|2CW6|C Chain C, Crystal Structure Of Human Hmg-Coa Lyase: Insights Into
           Catalysis And The Molecular Basis For
           Hydroxymethylglutaric Aciduria
 gi|83754899|pdb|2CW6|D Chain D, Crystal Structure Of Human Hmg-Coa Lyase: Insights Into
           Catalysis And The Molecular Basis For
           Hydroxymethylglutaric Aciduria
 gi|83754900|pdb|2CW6|E Chain E, Crystal Structure Of Human Hmg-Coa Lyase: Insights Into
           Catalysis And The Molecular Basis For
           Hydroxymethylglutaric Aciduria
 gi|83754901|pdb|2CW6|F Chain F, Crystal Structure Of Human Hmg-Coa Lyase: Insights Into
           Catalysis And The Molecular Basis For
           Hydroxymethylglutaric Aciduria
          Length = 298

 Score =  553 bits (1425), Expect = e-156,   Method: Composition-based stats.
 Identities = 284/298 (95%), Positives = 284/298 (95%)

Query: 28  TLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQMGD 87
           TLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQMGD
Sbjct: 1   TLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQMGD 60

Query: 88  HTEVLKGIQKFPGINYPVLTPNLXXXXXXXXXXXXXXVIFGAASELFTKKNINCSIEESF 147
           HTEVLKGIQKFPGINYPVLTPNL              VIFGAASELFTKKNINCSIEESF
Sbjct: 61  HTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNINCSIEESF 120

Query: 148 QRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLGDTIG 207
           QRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLGDTIG
Sbjct: 121 QRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLGDTIG 180

Query: 208 VGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGGCP 267
           VGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGGCP
Sbjct: 181 VGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGGCP 240

Query: 268 YAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQATCKL 325
           YAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQATCKL
Sbjct: 241 YAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQATCKL 298
>gi|13242293|ref|NP_077362.1| 3-hydroxy-3-methylglutaryl-Coenzyme A lyase [Rattus norvegicus]
 gi|2495261|sp|P97519|HMGCL_RAT Hydroxymethylglutaryl-CoA lyase, mitochondrial precursor (HMG-CoA
           lyase) (HL) (3-hydroxy-3-methylglutarate-CoA lyase)
 gi|1743378|emb|CAA71148.1| 3-hydroxy-3-methylglutaryl CoA lyase [Rattus norvegicus]
 gi|38511566|gb|AAH61797.1| 3-hydroxy-3-methylglutaryl-Coenzyme A lyase [Rattus norvegicus]
 gi|149024282|gb|EDL80779.1| 3-hydroxy-3-methylglutaryl-Coenzyme A lyase, isoform CRA_a [Rattus
           norvegicus]
          Length = 325

 Score =  546 bits (1408), Expect = e-154,   Method: Composition-based stats.
 Identities = 276/325 (84%), Positives = 298/325 (91%)

Query: 1   MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
           MA +RKA P+RLVGLASLRA STSSMGTLPKRVKIVEVGPRDGLQNEK+IV TPVKIKLI
Sbjct: 1   MATVRKAFPQRLVGLASLRAASTSSMGTLPKRVKIVEVGPRDGLQNEKSIVPTPVKIKLI 60

Query: 61  DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLXXXXXXXXXX 120
           DMLSEAGL VIE TSFVSPKWVPQM DH++VLKGIQKFPGINYPVLTPN+          
Sbjct: 61  DMLSEAGLPVIEATSFVSPKWVPQMADHSDVLKGIQKFPGINYPVLTPNMKGFEEAVAAG 120

Query: 121 XXXXVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
                IFGAASELFT+KN+NCSIEESFQRFD +++AA++A+ISVRGYVSCALGCPYEGK+
Sbjct: 121 AKEVSIFGAASELFTRKNVNCSIEESFQRFDGVMQAARAASISVRGYVSCALGCPYEGKV 180

Query: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
           SPAKVAEV KK YSMGCYEISLGDTIGVGTPG+MKDML+AV+ EVP+AALAVHCHDTYGQ
Sbjct: 181 SPAKVAEVAKKLYSMGCYEISLGDTIGVGTPGLMKDMLTAVLHEVPVAALAVHCHDTYGQ 240

Query: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
           ALANTL+ALQMGVSVVDSSVAGLGGCPYA+GASGNLATEDLVYML GLGIHTGVNLQKLL
Sbjct: 241 ALANTLVALQMGVSVVDSSVAGLGGCPYAKGASGNLATEDLVYMLTGLGIHTGVNLQKLL 300

Query: 301 EAGNFICQALNRKTSSKVAQATCKL 325
           EAG+FICQALNRKTSSKVAQATCKL
Sbjct: 301 EAGDFICQALNRKTSSKVAQATCKL 325
>gi|149694251|ref|XP_001504254.1| PREDICTED: similar to interleukin 13 receptor alpha 1-binding
           protein-1 [Equus caballus]
          Length = 325

 Score =  545 bits (1404), Expect = e-153,   Method: Composition-based stats.
 Identities = 283/325 (87%), Positives = 292/325 (89%)

Query: 1   MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
           MA +RK LPRRL GLASLRAVSTSS+GT PKRVKIVEVGPRDGLQNEKNIV T +KIKLI
Sbjct: 1   MATVRKGLPRRLAGLASLRAVSTSSVGTFPKRVKIVEVGPRDGLQNEKNIVPTAMKIKLI 60

Query: 61  DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLXXXXXXXXXX 120
           DMLSEAGL VIE TSFVSPKWVPQM DHTEVLKGIQKFPGINYPVLTPN           
Sbjct: 61  DMLSEAGLPVIEATSFVSPKWVPQMADHTEVLKGIQKFPGINYPVLTPNFKGFQAAVAAG 120

Query: 121 XXXXVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
                +FGAASELFTKKNINCSIEES QRF  +LKAA++A+I VRGYVSCALGCPYEGKI
Sbjct: 121 AKEVAVFGAASELFTKKNINCSIEESIQRFGEVLKAARAASIPVRGYVSCALGCPYEGKI 180

Query: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
           SPAKVAEVTKK YSMGCYEISLGDTIGVGTPG MKDMLSAVMQEVP+AALAVHCHDTYGQ
Sbjct: 181 SPAKVAEVTKKMYSMGCYEISLGDTIGVGTPGGMKDMLSAVMQEVPVAALAVHCHDTYGQ 240

Query: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
           ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYML GLGIHTGVNLQKLL
Sbjct: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLAGLGIHTGVNLQKLL 300

Query: 301 EAGNFICQALNRKTSSKVAQATCKL 325
           EAG FICQALNRKTSSKVAQATCKL
Sbjct: 301 EAGTFICQALNRKTSSKVAQATCKL 325
>gi|115495073|ref|NP_001068600.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase
           (hydroxymethylglutaricaciduria) [Bos taurus]
 gi|116242512|sp|Q29448|HMGCL_BOVIN Hydroxymethylglutaryl-CoA lyase, mitochondrial precursor (HMG-CoA
           lyase) (HL) (3-hydroxy-3-methylglutarate-CoA lyase)
 gi|109939905|gb|AAI18277.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase
           (hydroxymethylglutaricaciduria) [Bos taurus]
          Length = 325

 Score =  541 bits (1393), Expect = e-152,   Method: Composition-based stats.
 Identities = 276/325 (84%), Positives = 291/325 (89%)

Query: 1   MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
           MA ++K LPRRLVGLA+LRAVSTSS+GT PK+VKIVEVGPRDGLQNEKNIV TPVKIKLI
Sbjct: 1   MATVKKVLPRRLVGLATLRAVSTSSVGTFPKQVKIVEVGPRDGLQNEKNIVPTPVKIKLI 60

Query: 61  DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLXXXXXXXXXX 120
           DMLSEAGL V+E TSFVSPKWVPQM DH EVLKGIQKFPG+NYPVLTPN           
Sbjct: 61  DMLSEAGLPVVEATSFVSPKWVPQMADHAEVLKGIQKFPGVNYPVLTPNFKGFQAAVAAG 120

Query: 121 XXXXVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
                IFGAASELFTKKNINCSI+ES QRFD ILKAA++A ISVRGYVSC LGCPYEGKI
Sbjct: 121 AKEVAIFGAASELFTKKNINCSIDESLQRFDEILKAARAAGISVRGYVSCVLGCPYEGKI 180

Query: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
           SPAKVAEVTKK YSMGCYEISLGDTIGVGTPG MKDMLSAV+QEVP+ ALAVHCHDTYGQ
Sbjct: 181 SPAKVAEVTKKLYSMGCYEISLGDTIGVGTPGAMKDMLSAVLQEVPVTALAVHCHDTYGQ 240

Query: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
           ALANTL ALQMGVSV+DSSVAGLGGCPYAQGASGNLATEDLVYML GLGIHTGVNLQKLL
Sbjct: 241 ALANTLTALQMGVSVMDSSVAGLGGCPYAQGASGNLATEDLVYMLAGLGIHTGVNLQKLL 300

Query: 301 EAGNFICQALNRKTSSKVAQATCKL 325
           EAG FICQALNR+T+SKVAQATCKL
Sbjct: 301 EAGAFICQALNRRTNSKVAQATCKL 325
>gi|19343556|gb|AAH25440.1| Hmgcl protein [Mus musculus]
 gi|74180317|dbj|BAE32329.1| unnamed protein product [Mus musculus]
 gi|74204922|dbj|BAE20956.1| unnamed protein product [Mus musculus]
 gi|74208228|dbj|BAE26328.1| unnamed protein product [Mus musculus]
 gi|123122205|emb|CAM15901.1| 3-hydroxy-3-methylglutaryl-Coenzyme A lyase [Mus musculus]
 gi|148698016|gb|EDL29963.1| 3-hydroxy-3-methylglutaryl-Coenzyme A lyase [Mus musculus]
          Length = 325

 Score =  540 bits (1392), Expect = e-152,   Method: Composition-based stats.
 Identities = 273/325 (84%), Positives = 295/325 (90%)

Query: 1   MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
           MA++RKA PRRLVGL SLRAVSTSSMGTLPK+VKIVEVGPRDGLQNEK+IV TPVKI+LI
Sbjct: 1   MASVRKAFPRRLVGLTSLRAVSTSSMGTLPKQVKIVEVGPRDGLQNEKSIVPTPVKIRLI 60

Query: 61  DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLXXXXXXXXXX 120
           DMLSEAGL VIE TSFVSPKWVPQM DH++VLKGIQKFPGINYPVLTPN+          
Sbjct: 61  DMLSEAGLPVIEATSFVSPKWVPQMADHSDVLKGIQKFPGINYPVLTPNMKGFEEAVAAG 120

Query: 121 XXXXVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
                +FGA SELFT+KN NCSIEESFQRF  +++AAQ+A+ISVRGYVSCALGCPYEGK+
Sbjct: 121 AKEVSVFGAVSELFTRKNANCSIEESFQRFAGVMQAAQAASISVRGYVSCALGCPYEGKV 180

Query: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
           SPAKVAEV KK YSMGCYEISLGDTIGVGTPG+MKDML+AVM EVP+ ALAVHCHDTYGQ
Sbjct: 181 SPAKVAEVAKKLYSMGCYEISLGDTIGVGTPGLMKDMLTAVMHEVPVTALAVHCHDTYGQ 240

Query: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
           ALANTL+ALQMGVSVVDSSVAGLGGCPYA+GASGNLATEDLVYML GLGIHTGVNLQKLL
Sbjct: 241 ALANTLVALQMGVSVVDSSVAGLGGCPYAKGASGNLATEDLVYMLNGLGIHTGVNLQKLL 300

Query: 301 EAGNFICQALNRKTSSKVAQATCKL 325
           EAG+FICQALNRKTSSKVAQATCKL
Sbjct: 301 EAGDFICQALNRKTSSKVAQATCKL 325
>gi|6680233|ref|NP_032280.1| 3-hydroxy-3-methylglutaryl-Coenzyme A lyase [Mus musculus]
 gi|1292952|gb|AAB03107.1| 3-hydroxy-3-methylglutaryl-CoA lyase
          Length = 325

 Score =  538 bits (1385), Expect = e-151,   Method: Composition-based stats.
 Identities = 271/325 (83%), Positives = 295/325 (90%)

Query: 1   MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
           MA++RKA PRRLVGL SLRAVSTSSMGTLPK+VKIVEVGPRDGLQNEK+IV TPVKI+LI
Sbjct: 1   MASVRKAFPRRLVGLTSLRAVSTSSMGTLPKQVKIVEVGPRDGLQNEKSIVPTPVKIRLI 60

Query: 61  DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLXXXXXXXXXX 120
           D++SEAGL VIE TSFVSPKWVPQM DH++VLKGIQKFPGINYPVLTPN+          
Sbjct: 61  DIVSEAGLPVIEATSFVSPKWVPQMADHSDVLKGIQKFPGINYPVLTPNMKGFEEAVAAG 120

Query: 121 XXXXVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
                +FGA SELFT+KN NCSIEESFQRF  +++AAQ+A+ISVRGYVSCALGCPYEGK+
Sbjct: 121 AKEVSVFGAVSELFTRKNANCSIEESFQRFAGVMQAAQAASISVRGYVSCALGCPYEGKV 180

Query: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
           SPAKVAEV KK YSMGCYEISLGDTIGVGTPG+MKDML+AVM EVP+ ALAVHCHDTYGQ
Sbjct: 181 SPAKVAEVAKKLYSMGCYEISLGDTIGVGTPGLMKDMLTAVMHEVPVTALAVHCHDTYGQ 240

Query: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
           ALANTL+ALQMGVSVVDSSVAGLGGCPYA+GASGNLATEDLVYML GLGIHTGVNLQKLL
Sbjct: 241 ALANTLVALQMGVSVVDSSVAGLGGCPYAKGASGNLATEDLVYMLNGLGIHTGVNLQKLL 300

Query: 301 EAGNFICQALNRKTSSKVAQATCKL 325
           EAG+FICQALNRKTSSKVAQATCKL
Sbjct: 301 EAGDFICQALNRKTSSKVAQATCKL 325
>gi|74194970|dbj|BAE26056.1| unnamed protein product [Mus musculus]
          Length = 325

 Score =  536 bits (1380), Expect = e-150,   Method: Composition-based stats.
 Identities = 271/325 (83%), Positives = 293/325 (90%)

Query: 1   MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
           MA++RKA PRRLVGL SLRAVSTSSMGTLPK+VKIVEVGPRDGLQNEK+IV TPVKI+LI
Sbjct: 1   MASVRKAFPRRLVGLTSLRAVSTSSMGTLPKQVKIVEVGPRDGLQNEKSIVPTPVKIRLI 60

Query: 61  DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLXXXXXXXXXX 120
           DMLSEAGL VIE TSFVSPKWVPQM DH++VLKGIQKFPGINYPVLTPN+          
Sbjct: 61  DMLSEAGLPVIEATSFVSPKWVPQMADHSDVLKGIQKFPGINYPVLTPNMKGFEEAVAAG 120

Query: 121 XXXXVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
                +FGA SELFT+KN NCSIEESFQRF  +++AAQ+A+ISVRGYVSCALGCPYEGK+
Sbjct: 121 AKEVSVFGAVSELFTRKNANCSIEESFQRFAGVMQAAQAASISVRGYVSCALGCPYEGKV 180

Query: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
           SPAKVAEV KK YSMGCYEISLGDTIGVGTP  MKDML+AVM EVP+ ALAVHCHDTYGQ
Sbjct: 181 SPAKVAEVAKKLYSMGCYEISLGDTIGVGTPDXMKDMLTAVMHEVPVTALAVHCHDTYGQ 240

Query: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
           ALANTL+ALQMGVSVV+SSVAGLGGCPYA+GASGNLATEDLVYML GLGIHTGVNLQKLL
Sbjct: 241 ALANTLVALQMGVSVVNSSVAGLGGCPYAKGASGNLATEDLVYMLNGLGIHTGVNLQKLL 300

Query: 301 EAGNFICQALNRKTSSKVAQATCKL 325
           EAG+FICQALNRKTSSKVAQATCKL
Sbjct: 301 EAGDFICQALNRKTSSKVAQATCKL 325
>gi|585257|sp|P38060|HMGCL_MOUSE Hydroxymethylglutaryl-CoA lyase, mitochondrial precursor (HMG-CoA
           lyase) (HL) (3-hydroxy-3-methylglutarate-CoA lyase)
 gi|2143427|pir||I57009 3-Hydroxy-3-methylglutaryl coenzyme A lyase - mouse
 gi|409499|gb|AAB27965.1| 3-Hydroxy-3-methylglutaryl coenzyme A lyase; HL [Mus sp.]
          Length = 325

 Score =  534 bits (1375), Expect = e-150,   Method: Composition-based stats.
 Identities = 270/325 (83%), Positives = 292/325 (89%)

Query: 1   MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
           MA++RKA PRRLVGL SLRAVSTSSMGTLPK+VKIVEVGPRDGLQNEK+IV TPVKI+LI
Sbjct: 1   MASVRKAFPRRLVGLTSLRAVSTSSMGTLPKQVKIVEVGPRDGLQNEKSIVPTPVKIRLI 60

Query: 61  DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLXXXXXXXXXX 120
           DMLSEAGL VIE TSFVSP WVPQM DH++VLKGIQKFPGINYPVLTPN+          
Sbjct: 61  DMLSEAGLPVIEATSFVSPNWVPQMADHSDVLKGIQKFPGINYPVLTPNMKGFEEAVAAG 120

Query: 121 XXXXVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
                +FGA SELFT+KN NCSIEESFQRF  +++AAQ+A+ISVRGYVSCALGCPYEGK+
Sbjct: 121 AKEVSVFGAVSELFTRKNANCSIEESFQRFAGVMQAAQAASISVRGYVSCALGCPYEGKV 180

Query: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
           SPAKVAEV KK YSMGCYEISLGDTIGVGTPG+MKDML+AVM EVP+ AL VHCHDT GQ
Sbjct: 181 SPAKVAEVAKKLYSMGCYEISLGDTIGVGTPGLMKDMLTAVMHEVPVTALGVHCHDTIGQ 240

Query: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
           ALANTL+ALQMGVSVVDSSVAGLGGCPYA+GASGNLATEDLVYML GLGIHTGVNLQKLL
Sbjct: 241 ALANTLVALQMGVSVVDSSVAGLGGCPYAKGASGNLATEDLVYMLNGLGIHTGVNLQKLL 300

Query: 301 EAGNFICQALNRKTSSKVAQATCKL 325
           EAG+FICQALNRKTSSKVAQATCKL
Sbjct: 301 EAGDFICQALNRKTSSKVAQATCKL 325
>gi|108999140|ref|XP_001104722.1| PREDICTED: 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase
           (hydroxymethylglutaricaciduria) [Macaca mulatta]
          Length = 331

 Score =  531 bits (1368), Expect = e-149,   Method: Composition-based stats.
 Identities = 286/331 (86%), Positives = 288/331 (87%), Gaps = 6/331 (1%)

Query: 1   MAAMRKALPRRLVGLASLRAVSTSS------MGTLPKRVKIVEVGPRDGLQNEKNIVSTP 54
           MAAM KALPRRLVGLASLRAVS  S       GTL  RV  + V P  GL+   NIVSTP
Sbjct: 1   MAAMTKALPRRLVGLASLRAVSAPSRRGGGPAGTLTVRVGSLAVPPEWGLRFLTNIVSTP 60

Query: 55  VKIKLIDMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLXXXX 114
           VKIKLIDMLSEAGLSVIE TSFVSPKWVPQM DH EVLKGIQKFPGI YPVL PNL    
Sbjct: 61  VKIKLIDMLSEAGLSVIEATSFVSPKWVPQMADHAEVLKGIQKFPGITYPVLIPNLKGFE 120

Query: 115 XXXXXXXXXXVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGC 174
                      IFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSC LGC
Sbjct: 121 AAVAAGAKEVSIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCVLGC 180

Query: 175 PYEGKISPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHC 234
           PYEGKISPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVP AALAVHC
Sbjct: 181 PYEGKISPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPPAALAVHC 240

Query: 235 HDTYGQALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGV 294
           HDTYGQALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGV
Sbjct: 241 HDTYGQALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGV 300

Query: 295 NLQKLLEAGNFICQALNRKTSSKVAQATCKL 325
           NLQKLLEAGNFICQALNRKTSSKVAQATCKL
Sbjct: 301 NLQKLLEAGNFICQALNRKTSSKVAQATCKL 331
>gi|114554644|ref|XP_001166145.1| PREDICTED: similar to 3-hydroxymethyl-3-methylglutaryl-Coenzyme A
           lyase (hydroxymethylglutaricaciduria) isoform 1 [Pan
           troglodytes]
          Length = 293

 Score =  528 bits (1359), Expect = e-148,   Method: Composition-based stats.
 Identities = 284/325 (87%), Positives = 286/325 (88%), Gaps = 32/325 (9%)

Query: 1   MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
           MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKL+
Sbjct: 1   MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLV 60

Query: 61  DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLXXXXXXXXXX 120
           DMLSEAGLSVIETTSFVSPKWVPQ+                                   
Sbjct: 61  DMLSEAGLSVIETTSFVSPKWVPQVA--------------------------------AG 88

Query: 121 XXXXVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
               VIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI
Sbjct: 89  AKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 148

Query: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
           SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ
Sbjct: 149 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 208

Query: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
           ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL
Sbjct: 209 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 268

Query: 301 EAGNFICQALNRKTSSKVAQATCKL 325
           EAGNFICQALNRKTSSKVAQATCKL
Sbjct: 269 EAGNFICQALNRKTSSKVAQATCKL 293
>gi|73950222|ref|XP_535360.2| PREDICTED: similar to Hydroxymethylglutaryl-CoA lyase,
           mitochondrial precursor (HMG-CoA lyase) (HL)
           (3-hydroxy-3-methylglutarate-CoA lyase) isoform 1 [Canis
           familiaris]
          Length = 325

 Score =  522 bits (1344), Expect = e-146,   Method: Composition-based stats.
 Identities = 270/325 (83%), Positives = 281/325 (86%)

Query: 1   MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
           MAAMRK +PRRLVGLASLRAVST S+GT PK+VKIVEVG RDGLQNEKNIVST  KIKLI
Sbjct: 1   MAAMRKVVPRRLVGLASLRAVSTFSLGTFPKQVKIVEVGARDGLQNEKNIVSTSTKIKLI 60

Query: 61  DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLXXXXXXXXXX 120
           DMLSEAGL VIE TSFVSPKWVPQM D  EVLKGIQKFPGINYPVLTPN+          
Sbjct: 61  DMLSEAGLPVIEATSFVSPKWVPQMADCAEVLKGIQKFPGINYPVLTPNIKGFQAAVAAG 120

Query: 121 XXXXVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
                IF AASE FTKKN NCSI+E  QR D I +AAQ+A I VRGYVSC LGCPYEGKI
Sbjct: 121 AKEVTIFAAASEQFTKKNTNCSIDECLQRSDDIFRAAQAAGIPVRGYVSCVLGCPYEGKI 180

Query: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
           SPAKV EV KK YSMGCYEISLGDTIGVGTPG+MKDMLSAVM EVP++ALAVHCHDTYGQ
Sbjct: 181 SPAKVVEVAKKIYSMGCYEISLGDTIGVGTPGVMKDMLSAVMHEVPVSALAVHCHDTYGQ 240

Query: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
           ALANTLMALQMGVSVVDSSVAGLGGCPYA+GASGNLATEDLVYML GLGIHTGVNLQKLL
Sbjct: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYARGASGNLATEDLVYMLSGLGIHTGVNLQKLL 300

Query: 301 EAGNFICQALNRKTSSKVAQATCKL 325
           EAG FICQALNRKTSSKVAQA CKL
Sbjct: 301 EAGTFICQALNRKTSSKVAQAACKL 325
>gi|50759896|ref|XP_417834.1| PREDICTED: similar to Hydroxymethylglutaryl-CoA lyase (HMG-CoA
           lyase) (HL) (3-hydroxy-3-methylglutarate-CoA lyase)
           [Gallus gallus]
          Length = 319

 Score =  473 bits (1216), Expect = e-131,   Method: Composition-based stats.
 Identities = 238/325 (73%), Positives = 274/325 (84%), Gaps = 6/325 (1%)

Query: 1   MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
           MAA+R+ LPR  V   SLR VST++    P+RVK+VEVGPRDGLQNEK++V TPVKI+LI
Sbjct: 1   MAAVRRLLPRWAV---SLRPVSTAA---FPQRVKVVEVGPRDGLQNEKSVVPTPVKIRLI 54

Query: 61  DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLXXXXXXXXXX 120
           DMLSE GL VIE TSFVSP+WVPQM DH EV++GI K PG++YPVLTPNL          
Sbjct: 55  DMLSETGLPVIEATSFVSPRWVPQMADHAEVMQGINKLPGVSYPVLTPNLKGFQAAVAAG 114

Query: 121 XXXXVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
                IFGAASELFTKKNINCSIEES +RF  ++ AA++A+I VRGYVSC LGCPYEG I
Sbjct: 115 AKEVSIFGAASELFTKKNINCSIEESLERFSEVMNAARAASIPVRGYVSCVLGCPYEGNI 174

Query: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
           S AKVAEV+KK YSMGCYEISLGDTIG+GTPG MK+ML+AVM+EVP+ ALAVHCHDTYGQ
Sbjct: 175 SAAKVAEVSKKMYSMGCYEISLGDTIGIGTPGSMKEMLAAVMKEVPVGALAVHCHDTYGQ 234

Query: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
           ALAN L+ALQMGVSVVD+SVAGLGGCPYAQGASGN+ATEDLVYML GLGIHTGV+LQKL+
Sbjct: 235 ALANILVALQMGVSVVDASVAGLGGCPYAQGASGNVATEDLVYMLNGLGIHTGVDLQKLM 294

Query: 301 EAGNFICQALNRKTSSKVAQATCKL 325
           + G FIC ALNR+T+SKV+QA C+L
Sbjct: 295 DTGTFICNALNRRTNSKVSQAACRL 319
>gi|126328575|ref|XP_001363832.1| PREDICTED: similar to alpha-2-macroglobulin receptor [Monodelphis
           domestica]
          Length = 327

 Score =  460 bits (1183), Expect = e-128,   Method: Composition-based stats.
 Identities = 239/313 (76%), Positives = 267/313 (85%)

Query: 9   PRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGL 68
           P RL G +SLRA+S+SS+   PK+VKIVEVGPRDGLQNEK+I+ T +KIKLIDMLS AGL
Sbjct: 10  PLRLAGTSSLRAISSSSLDAFPKQVKIVEVGPRDGLQNEKHILPTQMKIKLIDMLSAAGL 69

Query: 69  SVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLXXXXXXXXXXXXXXVIFG 128
            VIE TSFVSPKWVPQM DH EVL+GI+KFPGI+YPVLTPNL               IFG
Sbjct: 70  PVIEATSFVSPKWVPQMADHAEVLQGIEKFPGISYPVLTPNLRGFQAAVAAGAKEVAIFG 129

Query: 129 AASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEV 188
           AASELF+KKNINCSIEES+QRF+ +L  A+ ANI VRGYVSC LGCPYEGK+SPAKVAEV
Sbjct: 130 AASELFSKKNINCSIEESYQRFEEVLTEARCANIPVRGYVSCVLGCPYEGKVSPAKVAEV 189

Query: 189 TKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMA 248
            KK YSMGC+EISLGDTIGVGTP  MK+MLSAVM+E+P++ALAVHCHDTYGQALAN LMA
Sbjct: 190 AKKLYSMGCFEISLGDTIGVGTPLGMKNMLSAVMKEMPVSALAVHCHDTYGQALANILMA 249

Query: 249 LQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQ 308
           LQMGVSVVDSSVAGLGGCPY+ GASGN+ATEDL+YML GLGI TGVNLQKL +AG FIC+
Sbjct: 250 LQMGVSVVDSSVAGLGGCPYSPGASGNVATEDLLYMLNGLGIDTGVNLQKLTDAGKFICK 309

Query: 309 ALNRKTSSKVAQA 321
           ALNRK SSKVA A
Sbjct: 310 ALNRKNSSKVATA 322
>gi|547653|sp|P35915|HMGCL_CHICK Hydroxymethylglutaryl-CoA lyase (HMG-CoA lyase) (HL)
           (3-hydroxy-3-methylglutarate-CoA lyase)
          Length = 298

 Score =  456 bits (1173), Expect = e-127,   Method: Composition-based stats.
 Identities = 223/297 (75%), Positives = 255/297 (85%)

Query: 29  LPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQMGDH 88
            P+RVK+VEVGPRDGLQNEK++V TPVKI+LIDMLSE GL VIE TSFVSP+WVPQM DH
Sbjct: 2   FPQRVKVVEVGPRDGLQNEKSVVPTPVKIRLIDMLSETGLPVIEATSFVSPRWVPQMADH 61

Query: 89  TEVLKGIQKFPGINYPVLTPNLXXXXXXXXXXXXXXVIFGAASELFTKKNINCSIEESFQ 148
            EV++GI K PG++YPVLTPNL               IFGAASELFTKKNINCSIEES +
Sbjct: 62  AEVMQGINKLPGVSYPVLTPNLKGFQAAVAAGAKEVSIFGAASELFTKKNINCSIEESLE 121

Query: 149 RFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLGDTIGV 208
           RF  ++ AA++A+I VRGYVSC LGCPYEG IS AKVAEV+KK YSMGCYEISLGD IG+
Sbjct: 122 RFSEVMNAARAASIPVRGYVSCVLGCPYEGNISAAKVAEVSKKMYSMGCYEISLGDRIGI 181

Query: 209 GTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGGCPY 268
           GTPG MK+ML+AVM+EVP+ ALAVHCHDTYGQALAN L+ALQMGVSVVD+SVAGLGGCPY
Sbjct: 182 GTPGSMKEMLAAVMKEVPVGALAVHCHDTYGQALANILVALQMGVSVVDASVAGLGGCPY 241

Query: 269 AQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQATCKL 325
           AQGASGN+ATEDLVYML GLGIHTGV+LQKL++ G FIC ALNR+T+SKV+QA C+L
Sbjct: 242 AQGASGNVATEDLVYMLNGLGIHTGVDLQKLMDTGTFICNALNRRTNSKVSQAACRL 298
>gi|41055014|ref|NP_957509.1| hypothetical protein LOC394190 [Danio rerio]
 gi|28277949|gb|AAH46023.1| Zgc:56248 [Danio rerio]
          Length = 340

 Score =  448 bits (1152), Expect = e-124,   Method: Composition-based stats.
 Identities = 224/312 (71%), Positives = 262/312 (83%), Gaps = 2/312 (0%)

Query: 16  ASLRAVSTSSMGT--LPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIET 73
           A +R+VS S+  +  LP+RVKIVEVGPRDGLQNEK IV T VKI+LIDMLSEAGL VIE 
Sbjct: 29  ALIRSVSVSAAASQALPERVKIVEVGPRDGLQNEKTIVPTEVKIRLIDMLSEAGLPVIEA 88

Query: 74  TSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLXXXXXXXXXXXXXXVIFGAASEL 133
           TSFVSPKWVPQM D  EV++G+ K PG+NYPVLTPNL               IFGAASEL
Sbjct: 89  TSFVSPKWVPQMADQEEVMRGLHKKPGVNYPVLTPNLKGFQAAVKAGAKEVAIFGAASEL 148

Query: 134 FTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFY 193
           F+KKNINCS+EES  RF+ ++ AA+   +SVRGYVSC LGCPYEGK+SP+KVAEV K+ Y
Sbjct: 149 FSKKNINCSVEESLVRFEEVMTAAKQEGVSVRGYVSCVLGCPYEGKVSPSKVAEVAKRLY 208

Query: 194 SMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGV 253
           SMGCYE+SLGDTIGVGTPG M +ML+AV +E+P+ ALAVHCHDTYGQALAN L+ALQ GV
Sbjct: 209 SMGCYEVSLGDTIGVGTPGGMTEMLNAVKKELPVEALAVHCHDTYGQALANILVALQNGV 268

Query: 254 SVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRK 313
           SVVDSSVAGLGGCPYAQGASGN+ATED+VYML GLGIHTGV+L +LL+AG+FIC ++NR+
Sbjct: 269 SVVDSSVAGLGGCPYAQGASGNVATEDVVYMLHGLGIHTGVDLPRLLDAGSFICHSINRR 328

Query: 314 TSSKVAQATCKL 325
           T+SKVAQA+CKL
Sbjct: 329 TNSKVAQASCKL 340