BLASTP 2.2.17 [Aug-26-2007]
Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Reference for composition-based statistics:
Schäffer, Alejandro A., L. Aravind, Thomas L. Madden,
Schaffer, Alejandro A., L. Aravind, Thomas L. Madden,
Sergei Shavirin, John L. Spouge, Yuri I. Wolf,
Eugene V. Koonin, and Stephen F. Altschul (2001),
"Improving the accuracy of PSI-BLAST protein database searches with
composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005.
Query= ENSG00000119912__[Homo_sapiens]
(1019 letters)
Database: nr.pal
6,348,806 sequences; 2,166,943,470 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|155969707|ref|NP_004960.2| insulysin [Homo sapiens] >gi|... 2045 0.0
gi|114631804|ref|XP_507922.2| PREDICTED: insulysin isoform ... 2043 0.0
gi|149690214|ref|XP_001501085.1| PREDICTED: similar to insu... 2039 0.0
gi|109089936|ref|XP_001090249.1| PREDICTED: insulysin isofo... 2034 0.0
gi|115495235|ref|NP_001069317.1| insulin-degrading enzyme [... 2024 0.0
gi|124157|sp|P14735|IDE_HUMAN Insulin-degrading enzyme (Ins... 2016 0.0
gi|114631806|ref|XP_001146582.1| PREDICTED: insulysin isofo... 2003 0.0
gi|6981076|ref|NP_037291.1| insulin degrading enzyme [Rattu... 1963 0.0
gi|121583922|ref|NP_112419.2| insulin degrading enzyme [Mus... 1962 0.0
gi|151567732|pdb|2JG4|A Chain A, Substrate-Free Ide Structu... 1959 0.0
gi|118137776|pdb|2G47|A Chain A, Crystal Structure Of Human... 1959 0.0
gi|114631808|ref|XP_001146520.1| PREDICTED: insulysin isofo... 1957 0.0
gi|14548072|sp|Q9JHR7|IDE_MOUSE Insulin-degrading enzyme (I... 1955 0.0
gi|73998234|ref|XP_534963.2| PREDICTED: similar to Insulin-... 1952 0.0
gi|109089938|ref|XP_001090137.1| PREDICTED: insulysin isofo... 1951 0.0
gi|149631907|ref|XP_001506502.1| PREDICTED: similar to insu... 1922 0.0
gi|148709839|gb|EDL41785.1| insulin degrading enzyme [Mus m... 1898 0.0
gi|148238275|ref|NP_001082994.1| insulin-degrading enzyme [... 1800 0.0
gi|146455165|dbj|BAF62161.1| insulin-degrading enzyme [Dani... 1798 0.0
gi|114631810|ref|XP_001146439.1| PREDICTED: insulysin isofo... 1707 0.0
gi|109089940|ref|XP_001090017.1| PREDICTED: insulysin isofo... 1701 0.0
gi|62087988|dbj|BAD92441.1| insulysin variant [Homo sapiens] 1202 0.0
gi|156374406|ref|XP_001629798.1| predicted protein [Nematos... 1165 0.0
gi|119570477|gb|EAW50092.1| insulin-degrading enzyme, isofo... 1077 0.0
gi|91077850|ref|XP_971897.1| PREDICTED: similar to Insulin-... 1075 0.0
gi|156553458|ref|XP_001603463.1| PREDICTED: similar to meta... 1066 0.0
gi|157130296|ref|XP_001661876.1| metalloprotease [Aedes aeg... 983 0.0
gi|170039557|ref|XP_001847597.1| metalloprotease [Culex pip... 982 0.0
gi|118092865|ref|XP_421686.2| PREDICTED: similar to insulin... 967 0.0
gi|47212631|emb|CAF89725.1| unnamed protein product [Tetrao... 944 0.0
gi|115960881|ref|XP_001194830.1| PREDICTED: similar to Insu... 910 0.0
gi|115754788|ref|XP_795975.2| PREDICTED: similar to Insulin... 904 0.0
gi|29335981|gb|AAO74689.1| RE17458p [Drosophila melanogaster] 903 0.0
gi|24667426|ref|NP_524182.2| Insulin degrading metalloprote... 902 0.0
gi|85701357|sp|P22817|IDE_DROME Insulin-degrading enzyme (I... 900 0.0
gi|158290012|ref|XP_311589.4| AGAP010351-PA [Anopheles gamb... 897 0.0
gi|157168|gb|AAA28439.1| insulin-degrading enzyme 892 0.0
gi|125980214|ref|XP_001354132.1| GA18943-PA [Drosophila pse... 885 0.0
gi|170583894|ref|XP_001896776.1| insulin-degrading enzyme, ... 815 0.0
gi|157107788|ref|XP_001649937.1| metalloprotease [Aedes aeg... 793 0.0
gi|157763786|ref|XP_001674236.1| Hypothetical protein CBG09... 768 0.0
gi|50556892|ref|XP_505854.1| hypothetical protein [Yarrowia... 752 0.0
gi|25146566|ref|NP_741542.1| F44E7.4b [Caenorhabditis elega... 751 0.0
gi|71018347|ref|XP_759404.1| hypothetical protein UM03257.1... 745 0.0
gi|25146563|ref|NP_741543.1| F44E7.4a [Caenorhabditis elega... 742 0.0
gi|32566665|ref|NP_504514.2| F44E7.4c [Caenorhabditis elega... 742 0.0
gi|71994338|ref|NP_001023928.1| F44E7.4d [Caenorhabditis el... 733 0.0
gi|164660082|ref|XP_001731164.1| hypothetical protein MGL_1... 733 0.0
gi|72001443|ref|NP_507226.2| Y70C5C.1 [Caenorhabditis elega... 718 0.0
gi|70985270|ref|XP_748141.1| a-pheromone processing metallo... 718 0.0
gi|159125935|gb|EDP51051.1| a-pheromone processing metallop... 717 0.0
gi|119499149|ref|XP_001266332.1| a-pheromone processing met... 712 0.0
gi|168036094|ref|XP_001770543.1| predicted protein [Physcom... 710 0.0
gi|67902114|ref|XP_681313.1| hypothetical protein AN8044.2 ... 704 0.0
gi|168018705|ref|XP_001761886.1| predicted protein [Physcom... 699 0.0
gi|121719273|ref|XP_001276340.1| a-pheromone processing met... 695 0.0
gi|111380663|gb|ABH09708.1| STE23-like protein [Penicillium... 689 0.0
gi|151940910|gb|EDN59292.1| metalloprotease [Saccharomyces ... 687 0.0
gi|85078440|ref|XP_956166.1| hypothetical protein NCU00481 ... 687 0.0
gi|145251972|ref|XP_001397499.1| hypothetical protein An16g... 686 0.0
gi|42742289|ref|NP_013493.2| Metalloprotease involved, with... 686 0.0
gi|119182813|ref|XP_001242515.1| hypothetical protein CIMG_... 683 0.0
gi|157348694|emb|CAO23586.1| unnamed protein product [Vitis... 683 0.0
gi|169771821|ref|XP_001820380.1| [Aspergillus oryzae] >gi|8... 683 0.0
gi|15485612|emb|CAC67408.1| insulin degrading enzyme [Solan... 677 0.0
gi|115472891|ref|NP_001060044.1| Os07g0570300 [Oryza sativa... 675 0.0
gi|110741612|dbj|BAE98754.1| putative zinc protease [Arabid... 667 0.0
gi|15227435|ref|NP_181710.1| peptidase M16 family protein /... 667 0.0
gi|115440299|ref|NP_001044429.1| Os01g0778800 [Oryza sativa... 662 0.0
gi|169615713|ref|XP_001801272.1| hypothetical protein SNOG_... 659 0.0
gi|145615549|ref|XP_360292.2| hypothetical protein MGG_1314... 659 0.0
gi|168022776|ref|XP_001763915.1| predicted protein [Physcom... 657 0.0
gi|46125067|ref|XP_387087.1| hypothetical protein FG06911.1... 656 0.0
gi|33146781|dbj|BAC79699.1| putative insulin degrading enzy... 655 0.0
gi|157348693|emb|CAO23585.1| unnamed protein product [Vitis... 654 0.0
gi|50308347|ref|XP_454175.1| unnamed protein product [Kluyv... 652 0.0
gi|134115569|ref|XP_773498.1| hypothetical protein CNBI1120... 651 0.0
gi|58261390|ref|XP_568105.1| insulin degrading enzyme [Cryp... 650 0.0
gi|115443270|ref|XP_001218442.1| hypothetical protein ATEG_... 649 0.0
gi|125600783|gb|EAZ40359.1| hypothetical protein OsJ_023842... 645 0.0
gi|125558861|gb|EAZ04397.1| hypothetical protein OsI_025629... 645 0.0
gi|156847399|ref|XP_001646584.1| hypothetical protein Kpol_... 643 0.0
gi|168046294|ref|XP_001775609.1| predicted protein [Physcom... 633 e-179
gi|6706418|emb|CAB66104.1| protease-like protein [Arabidops... 632 e-179
gi|125558862|gb|EAZ04398.1| hypothetical protein OsI_025630... 628 e-178
gi|45190659|ref|NP_984913.1| AER053Cp [Ashbya gossypii ATCC... 627 e-177
gi|154284960|ref|XP_001543275.1| conserved hypothetical pro... 626 e-177
gi|50289291|ref|XP_447076.1| unnamed protein product [Candi... 623 e-176
gi|145238158|ref|XP_001391726.1| hypothetical protein An07g... 622 e-176
gi|156048290|ref|XP_001590112.1| hypothetical protein SS1G_... 622 e-176
gi|19114878|ref|NP_593966.1| metallopeptidase [Schizosaccha... 621 e-176
gi|125527921|gb|EAY76035.1| hypothetical protein OsI_003882... 617 e-174
gi|71982342|ref|NP_504531.2| C02G6.2 [Caenorhabditis elegan... 612 e-173
gi|150864794|ref|XP_001383768.2| hypothetical protein PICST... 610 e-172
gi|68473366|ref|XP_719241.1| a-factor pheromone maturation ... 606 e-171
gi|53792210|dbj|BAD52843.1| putative insulin degrading enzy... 603 e-170
gi|146421697|ref|XP_001486793.1| hypothetical protein PGUG_... 594 e-167
gi|50405813|ref|XP_456547.1| hypothetical protein DEHA0A052... 594 e-167
gi|125600784|gb|EAZ40360.1| hypothetical protein OsJ_023843... 588 e-166
gi|149236525|ref|XP_001524140.1| conserved hypothetical pro... 587 e-165
>gi|155969707|ref|NP_004960.2| insulysin [Homo sapiens]
gi|55959215|emb|CAI13670.1| insulin-degrading enzyme [Homo sapiens]
gi|64653345|gb|AAH96337.1| Insulin-degrading enzyme [Homo sapiens]
gi|64653350|gb|AAH96339.1| Insulin-degrading enzyme [Homo sapiens]
gi|64654515|gb|AAH96336.1| Insulin-degrading enzyme [Homo sapiens]
gi|119570475|gb|EAW50090.1| insulin-degrading enzyme, isoform CRA_a [Homo sapiens]
gi|119570476|gb|EAW50091.1| insulin-degrading enzyme, isoform CRA_a [Homo sapiens]
Length = 1019
Score = 2045 bits (5299), Expect = 0.0, Method: Composition-based stats.
Identities = 1004/1019 (98%), Positives = 1004/1019 (98%)
Query: 1 MRYRLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED 60
MRYRLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED
Sbjct: 1 MRYRLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED 60
Query: 61 KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK 120
KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK
Sbjct: 61 KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK 120
Query: 121 YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD 180
YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD
Sbjct: 121 YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD 180
Query: 181 REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE 240
REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE
Sbjct: 181 REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE 240
Query: 241 LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVXXXXXXXXXXXXXXXKQ 300
LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNV KQ
Sbjct: 241 LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ 300
Query: 301 LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV 360
LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV
Sbjct: 301 LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV 360
Query: 361 GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 420
GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV
Sbjct: 361 GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 420
Query: 421 AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI 480
AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI
Sbjct: 421 AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI 480
Query: 481 VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL 540
VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL
Sbjct: 481 VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL 540
Query: 541 EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL 600
EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL
Sbjct: 541 EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL 600
Query: 601 KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE 660
KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE
Sbjct: 601 KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE 660
Query: 661 IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 720
IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL
Sbjct: 661 IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 720
Query: 721 SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 780
SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ
Sbjct: 721 SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 780
Query: 781 QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 840
QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA
Sbjct: 781 QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 840
Query: 841 NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL 900
NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL
Sbjct: 841 NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL 900
Query: 901 SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA 960
SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA
Sbjct: 901 SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA 960
Query: 961 REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL 1019
REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL
Sbjct: 961 REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL 1019
>gi|114631804|ref|XP_507922.2| PREDICTED: insulysin isoform 4 [Pan troglodytes]
Length = 1019
Score = 2043 bits (5293), Expect = 0.0, Method: Composition-based stats.
Identities = 1003/1019 (98%), Positives = 1003/1019 (98%)
Query: 1 MRYRLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED 60
MRYRLAWLLHPAL STFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED
Sbjct: 1 MRYRLAWLLHPALSSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED 60
Query: 61 KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK 120
KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK
Sbjct: 61 KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK 120
Query: 121 YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD 180
YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD
Sbjct: 121 YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD 180
Query: 181 REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE 240
REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE
Sbjct: 181 REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE 240
Query: 241 LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVXXXXXXXXXXXXXXXKQ 300
LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNV KQ
Sbjct: 241 LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ 300
Query: 301 LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV 360
LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV
Sbjct: 301 LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV 360
Query: 361 GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 420
GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV
Sbjct: 361 GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 420
Query: 421 AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI 480
AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI
Sbjct: 421 AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI 480
Query: 481 VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL 540
VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL
Sbjct: 481 VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL 540
Query: 541 EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL 600
EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL
Sbjct: 541 EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL 600
Query: 601 KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE 660
KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE
Sbjct: 601 KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE 660
Query: 661 IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 720
IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL
Sbjct: 661 IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 720
Query: 721 SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 780
SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ
Sbjct: 721 SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 780
Query: 781 QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 840
QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA
Sbjct: 781 QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 840
Query: 841 NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL 900
NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL
Sbjct: 841 NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL 900
Query: 901 SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA 960
SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA
Sbjct: 901 SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA 960
Query: 961 REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL 1019
REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL
Sbjct: 961 REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL 1019
>gi|149690214|ref|XP_001501085.1| PREDICTED: similar to insulin-degrading enzyme [Equus caballus]
Length = 1212
Score = 2039 bits (5283), Expect = 0.0, Method: Composition-based stats.
Identities = 990/1019 (97%), Positives = 997/1019 (97%)
Query: 1 MRYRLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED 60
MRYRLAWLLHPALPSTFRS LGARLPPPERL GFQKKTYSKMNNPAIKR+GNHI KSPED
Sbjct: 194 MRYRLAWLLHPALPSTFRSALGARLPPPERLSGFQKKTYSKMNNPAIKRLGNHIIKSPED 253
Query: 61 KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK 120
KREYRGL+LANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK
Sbjct: 254 KREYRGLQLANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK 313
Query: 121 YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD 180
YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD
Sbjct: 314 YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD 373
Query: 181 REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE 240
REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE
Sbjct: 374 REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE 433
Query: 241 LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVXXXXXXXXXXXXXXXKQ 300
LLKFHS YYSSNLMA+CVLGRESLDDLT+LVVKLFSEVENKNV KQ
Sbjct: 434 LLKFHSTYYSSNLMAICVLGRESLDDLTDLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ 493
Query: 301 LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV 360
LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV
Sbjct: 494 LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV 553
Query: 361 GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 420
GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV
Sbjct: 554 GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 613
Query: 421 AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI 480
AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVA+
Sbjct: 614 AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAV 673
Query: 481 VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL 540
VSKSFEGKTD TEEWYGTQY+QEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEIL L
Sbjct: 674 VSKSFEGKTDCTEEWYGTQYRQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILSL 733
Query: 541 EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL 600
EKEATPYP+LIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL
Sbjct: 734 EKEATPYPSLIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL 793
Query: 601 KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE 660
KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE
Sbjct: 794 KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE 853
Query: 661 IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 720
IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL
Sbjct: 854 IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 913
Query: 721 SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 780
SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ
Sbjct: 914 SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 973
Query: 781 QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 840
QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA
Sbjct: 974 QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 1033
Query: 841 NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL 900
NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL
Sbjct: 1034 NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL 1093
Query: 901 SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA 960
SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA
Sbjct: 1094 SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA 1153
Query: 961 REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL 1019
REMDSCPVVGEFPCQNDINLSQAP LPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL
Sbjct: 1154 REMDSCPVVGEFPCQNDINLSQAPGLPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL 1212
>gi|109089936|ref|XP_001090249.1| PREDICTED: insulysin isoform 3 [Macaca mulatta]
Length = 1019
Score = 2035 bits (5271), Expect = 0.0, Method: Composition-based stats.
Identities = 998/1019 (97%), Positives = 1001/1019 (98%)
Query: 1 MRYRLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED 60
MRYRLAWL HPALPSTFRSV GARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED
Sbjct: 1 MRYRLAWLRHPALPSTFRSVFGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED 60
Query: 61 KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK 120
KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK
Sbjct: 61 KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK 120
Query: 121 YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD 180
YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD
Sbjct: 121 YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD 180
Query: 181 REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE 240
REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE
Sbjct: 181 REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE 240
Query: 241 LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVXXXXXXXXXXXXXXXKQ 300
LLKFHS YYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENK+V KQ
Sbjct: 241 LLKFHSTYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKSVPLPEFPEHPFQEEHLKQ 300
Query: 301 LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV 360
LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV
Sbjct: 301 LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV 360
Query: 361 GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 420
GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV
Sbjct: 361 GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 420
Query: 421 AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI 480
AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVA+
Sbjct: 421 AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAV 480
Query: 481 VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL 540
VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL
Sbjct: 481 VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL 540
Query: 541 EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL 600
EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL
Sbjct: 541 EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL 600
Query: 601 KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE 660
KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE
Sbjct: 601 KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE 660
Query: 661 IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 720
IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL
Sbjct: 661 IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 720
Query: 721 SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 780
SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ
Sbjct: 721 SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 780
Query: 781 QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 840
QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA
Sbjct: 781 QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 840
Query: 841 NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL 900
NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL
Sbjct: 841 NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL 900
Query: 901 SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA 960
SAECAKYWGEIISQQY+FDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA
Sbjct: 901 SAECAKYWGEIISQQYHFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA 960
Query: 961 REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL 1019
REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL
Sbjct: 961 REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL 1019
>gi|115495235|ref|NP_001069317.1| insulin-degrading enzyme [Bos taurus]
gi|122135053|sp|Q24K02|IDE_BOVIN Insulin-degrading enzyme (Insulysin) (Insulinase) (Insulin protease)
gi|89994089|gb|AAI14106.1| Similar to Insulin-degrading enzyme (Insulysin) (Insulinase) (Insulin
protease) [Bos taurus]
Length = 1019
Score = 2024 bits (5244), Expect = 0.0, Method: Composition-based stats.
Identities = 992/1019 (97%), Positives = 996/1019 (97%)
Query: 1 MRYRLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED 60
MRYRLAWLLH ALPSTFRSVLGARLPP ERLCGFQKKTYSKMNNPAIKRIG+HI KS ED
Sbjct: 1 MRYRLAWLLHSALPSTFRSVLGARLPPSERLCGFQKKTYSKMNNPAIKRIGHHIIKSHED 60
Query: 61 KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK 120
KREYRGLELANGIKVLL+SDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK
Sbjct: 61 KREYRGLELANGIKVLLVSDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK 120
Query: 121 YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD 180
YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD
Sbjct: 121 YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD 180
Query: 181 REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE 240
REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE
Sbjct: 181 REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE 240
Query: 241 LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVXXXXXXXXXXXXXXXKQ 300
LLKFHS YYSSNLMA+CVLGRESLDDLTNLVVKLFSEVENKNV KQ
Sbjct: 241 LLKFHSTYYSSNLMAICVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ 300
Query: 301 LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV 360
LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV
Sbjct: 301 LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV 360
Query: 361 GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 420
GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV
Sbjct: 361 GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 420
Query: 421 AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI 480
AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI
Sbjct: 421 AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI 480
Query: 481 VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL 540
VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLP KNEFIPTNFEIL L
Sbjct: 481 VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPMKNEFIPTNFEILSL 540
Query: 541 EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL 600
EKEATPYP+LIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL
Sbjct: 541 EKEATPYPSLIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL 600
Query: 601 KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE 660
KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE
Sbjct: 601 KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE 660
Query: 661 IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 720
IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL
Sbjct: 661 IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 720
Query: 721 SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 780
SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ
Sbjct: 721 SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 780
Query: 781 QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 840
QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA
Sbjct: 781 QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 840
Query: 841 NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL 900
NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL
Sbjct: 841 NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL 900
Query: 901 SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA 960
SAECAKYWGEIISQQYNFDRDN EVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA
Sbjct: 901 SAECAKYWGEIISQQYNFDRDNIEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA 960
Query: 961 REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL 1019
REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL
Sbjct: 961 REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL 1019
>gi|124157|sp|P14735|IDE_HUMAN Insulin-degrading enzyme (Insulysin) (Insulinase) (Insulin protease)
gi|184556|gb|AAA52712.1| insulin-degrading enzyme
Length = 1019
Score = 2016 bits (5224), Expect = 0.0, Method: Composition-based stats.
Identities = 998/1019 (97%), Positives = 999/1019 (98%)
Query: 1 MRYRLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED 60
MRYRLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED
Sbjct: 1 MRYRLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED 60
Query: 61 KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK 120
KREYRGLELANGIKVLL+SDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK
Sbjct: 61 KREYRGLELANGIKVLLMSDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK 120
Query: 121 YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD 180
YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD
Sbjct: 121 YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD 180
Query: 181 REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE 240
REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE
Sbjct: 181 REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE 240
Query: 241 LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVXXXXXXXXXXXXXXXKQ 300
LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNV KQ
Sbjct: 241 LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ 300
Query: 301 LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV 360
LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV
Sbjct: 301 LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV 360
Query: 361 GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 420
GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV
Sbjct: 361 GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 420
Query: 421 AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI 480
AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI
Sbjct: 421 AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI 480
Query: 481 VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL 540
VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL
Sbjct: 481 VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL 540
Query: 541 EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL 600
EKEATPYPALIKDT MSKLWFKQDDK PKACLNFEFFSPFAYVDPLHCNMAYLYLELL
Sbjct: 541 EKEATPYPALIKDTVMSKLWFKQDDKKKKPKACLNFEFFSPFAYVDPLHCNMAYLYLELL 600
Query: 601 KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE 660
KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE
Sbjct: 601 KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE 660
Query: 661 IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 720
IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL
Sbjct: 661 IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 720
Query: 721 SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 780
SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ
Sbjct: 721 SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 780
Query: 781 QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 840
QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA
Sbjct: 781 QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 840
Query: 841 NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL 900
NGIQ LRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL
Sbjct: 841 NGIQSLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL 900
Query: 901 SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA 960
SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA
Sbjct: 901 SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA 960
Query: 961 REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL 1019
REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL
Sbjct: 961 REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL 1019
>gi|114631806|ref|XP_001146582.1| PREDICTED: insulysin isoform 3 [Pan troglodytes]
Length = 1019
Score = 2003 bits (5188), Expect = 0.0, Method: Composition-based stats.
Identities = 980/1019 (96%), Positives = 988/1019 (96%)
Query: 1 MRYRLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED 60
MRYRLAWLLHPAL STFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED
Sbjct: 1 MRYRLAWLLHPALSSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED 60
Query: 61 KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK 120
KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK
Sbjct: 61 KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK 120
Query: 121 YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD 180
YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD
Sbjct: 121 YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD 180
Query: 181 REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE 240
REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE
Sbjct: 181 REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE 240
Query: 241 LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVXXXXXXXXXXXXXXXKQ 300
LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNV KQ
Sbjct: 241 LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ 300
Query: 301 LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV 360
LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV
Sbjct: 301 LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV 360
Query: 361 GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 420
GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV
Sbjct: 361 GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 420
Query: 421 AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI 480
AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI
Sbjct: 421 AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI 480
Query: 481 VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL 540
VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL
Sbjct: 481 VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL 540
Query: 541 EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL 600
EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFS + Y DPLHCNM YL++ LL
Sbjct: 541 EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSRYIYADPLHCNMTYLFIRLL 600
Query: 601 KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE 660
KD L EY YAA L+GLSY + + + + LSVKGYNDKQPILLKKIIEKMATFEIDEKRFE
Sbjct: 601 KDDLKEYTYAARLSGLSYGIASGMNAILLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE 660
Query: 661 IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 720
IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL
Sbjct: 661 IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 720
Query: 721 SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 780
SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ
Sbjct: 721 SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 780
Query: 781 QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 840
QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA
Sbjct: 781 QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 840
Query: 841 NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL 900
NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL
Sbjct: 841 NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL 900
Query: 901 SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA 960
SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA
Sbjct: 901 SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA 960
Query: 961 REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL 1019
REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL
Sbjct: 961 REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL 1019
>gi|6981076|ref|NP_037291.1| insulin degrading enzyme [Rattus norvegicus]
gi|547706|sp|P35559|IDE_RAT Insulin-degrading enzyme (Insulysin) (Insulinase) (Insulin protease)
gi|56492|emb|CAA47689.1| insulin-degrading enzyme [Rattus norvegicus]
gi|149062773|gb|EDM13196.1| insulin degrading enzyme [Rattus norvegicus]
Length = 1019
Score = 1963 bits (5086), Expect = 0.0, Method: Composition-based stats.
Identities = 958/1019 (94%), Positives = 980/1019 (96%)
Query: 1 MRYRLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED 60
MR L WLLHPALPST S+LGAR PP +RLCGF K+ YS MNNPAI+RI +HI KSPED
Sbjct: 1 MRNGLVWLLHPALPSTLHSILGARPPPVKRLCGFPKQIYSTMNNPAIQRIEDHIVKSPED 60
Query: 61 KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK 120
KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNI GLSHFCEHMLFLGTKK
Sbjct: 61 KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIPGLSHFCEHMLFLGTKK 120
Query: 121 YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD 180
YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFD SCKD
Sbjct: 121 YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDASCKD 180
Query: 181 REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE 240
REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVR+E
Sbjct: 181 REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVREE 240
Query: 241 LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVXXXXXXXXXXXXXXXKQ 300
LLKFHS YYSSNLMA+CVLGRESLDDLTNLVVKLFSEVENKNV KQ
Sbjct: 241 LLKFHSTYYSSNLMAICVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ 300
Query: 301 LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV 360
LYKIVPIKDIRNLYVTFPIPDLQ+YYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV
Sbjct: 301 LYKIVPIKDIRNLYVTFPIPDLQQYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV 360
Query: 361 GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 420
GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV
Sbjct: 361 GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 420
Query: 421 AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI 480
AFRFKDKERPRGYTSKIAG LHYYPL VLTAEYLLEEFRPDLI+MVLDKLRPENVRVAI
Sbjct: 421 AFRFKDKERPRGYTSKIAGKLHYYPLNGVLTAEYLLEEFRPDLIDMVLDKLRPENVRVAI 480
Query: 481 VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL 540
VSKSFEGKTDRTE+WYGTQYKQEAIP++VI+KWQNADLNGKFKLPTKNEFIPTNFEIL L
Sbjct: 481 VSKSFEGKTDRTEQWYGTQYKQEAIPEDVIQKWQNADLNGKFKLPTKNEFIPTNFEILAL 540
Query: 541 EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL 600
EK+ATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL
Sbjct: 541 EKDATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL 600
Query: 601 KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE 660
KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKI EKMATFEID+KRFE
Sbjct: 601 KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKITEKMATFEIDKKRFE 660
Query: 661 IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 720
IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL
Sbjct: 661 IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 720
Query: 721 SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 780
SRLHIEALLHGNITKQAALG+MQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ
Sbjct: 721 SRLHIEALLHGNITKQAALGVMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 780
Query: 781 QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 840
+RNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA
Sbjct: 781 RRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 840
Query: 841 NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL 900
NGIQGLRFIIQSEKPPHYLESRVEAFLITMEK+IEDMTEEAFQKHIQALAIRRLDKPKKL
Sbjct: 841 NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKAIEDMTEEAFQKHIQALAIRRLDKPKKL 900
Query: 901 SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA 960
SAECAKYWGEIISQQYN+DRDN EVAYLKTL+K+DIIKFYKEMLAVDAPRRHKVSVHVLA
Sbjct: 901 SAECAKYWGEIISQQYNYDRDNIEVAYLKTLSKDDIIKFYKEMLAVDAPRRHKVSVHVLA 960
Query: 961 REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL 1019
REMDSCPVVGEFP QNDINLS+AP LPQPEVI NMTEFKRGLPLFPLVKPHINFMAAKL
Sbjct: 961 REMDSCPVVGEFPSQNDINLSEAPPLPQPEVIHNMTEFKRGLPLFPLVKPHINFMAAKL 1019
>gi|121583922|ref|NP_112419.2| insulin degrading enzyme [Mus musculus]
gi|27371196|gb|AAH41675.1| Insulin degrading enzyme [Mus musculus]
Length = 1019
Score = 1962 bits (5082), Expect = 0.0, Method: Composition-based stats.
Identities = 955/1019 (93%), Positives = 980/1019 (96%)
Query: 1 MRYRLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED 60
MR L WLLHPALP T RS+LGAR PP +RLCGF K+TYS M+NPAI+RI + I KSPED
Sbjct: 1 MRNGLVWLLHPALPGTLRSILGARPPPAKRLCGFPKQTYSTMSNPAIQRIEDQIVKSPED 60
Query: 61 KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK 120
KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNI GLSHFCEHMLFLGTKK
Sbjct: 61 KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIPGLSHFCEHMLFLGTKK 120
Query: 121 YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD 180
YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFD SCKD
Sbjct: 121 YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDASCKD 180
Query: 181 REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE 240
REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVR+E
Sbjct: 181 REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVREE 240
Query: 241 LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVXXXXXXXXXXXXXXXKQ 300
LLKFHS YYSSNLMA+CVLGRESLDDLTNLVVKLFSEVENKNV +Q
Sbjct: 241 LLKFHSTYYSSNLMAICVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLRQ 300
Query: 301 LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV 360
LYKIVPIKDIRNLYVTFPIPDLQ+YYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV
Sbjct: 301 LYKIVPIKDIRNLYVTFPIPDLQQYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV 360
Query: 361 GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 420
GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV
Sbjct: 361 GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 420
Query: 421 AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI 480
AFRFKDKERPRGYTSKIAG LHYYPL VLTAEYLLEEFRPDLI+MVLDKLRPENVRVAI
Sbjct: 421 AFRFKDKERPRGYTSKIAGKLHYYPLNGVLTAEYLLEEFRPDLIDMVLDKLRPENVRVAI 480
Query: 481 VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL 540
VSKSFEGKTDRTE+WYGTQYKQEAIP+++I+KWQNADLNGKFKLPTKNEFIPTNFEIL L
Sbjct: 481 VSKSFEGKTDRTEQWYGTQYKQEAIPEDIIQKWQNADLNGKFKLPTKNEFIPTNFEILSL 540
Query: 541 EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL 600
EK+ATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL
Sbjct: 541 EKDATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL 600
Query: 601 KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE 660
KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKI EKMATFEID+KRFE
Sbjct: 601 KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKITEKMATFEIDKKRFE 660
Query: 661 IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 720
IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL
Sbjct: 661 IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 720
Query: 721 SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 780
SRLHIEALLHGNITKQAALG+MQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ
Sbjct: 721 SRLHIEALLHGNITKQAALGVMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 780
Query: 781 QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 840
QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA
Sbjct: 781 QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 840
Query: 841 NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL 900
NGIQGLRFIIQSEKPPHYLESRVEAFLITMEK+IEDMTEEAFQKHIQALAIRRLDKPKKL
Sbjct: 841 NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKAIEDMTEEAFQKHIQALAIRRLDKPKKL 900
Query: 901 SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA 960
SAECAKYWGEIISQQYN+DRDN EVAYLKTLTK+DII+FY+EMLAVDAPRRHKVSVHVLA
Sbjct: 901 SAECAKYWGEIISQQYNYDRDNIEVAYLKTLTKDDIIRFYQEMLAVDAPRRHKVSVHVLA 960
Query: 961 REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL 1019
REMDSCPVVGEFP QNDINLS+AP LPQPEVI NMTEFKRGLPLFPLVKPHINFMAAKL
Sbjct: 961 REMDSCPVVGEFPSQNDINLSEAPPLPQPEVIHNMTEFKRGLPLFPLVKPHINFMAAKL 1019
>gi|151567732|pdb|2JG4|A Chain A, Substrate-Free Ide Structure In Its Closed Conformation
gi|151567733|pdb|2JG4|B Chain B, Substrate-Free Ide Structure In Its Closed Conformation
Length = 990
Score = 1959 bits (5076), Expect = 0.0, Method: Composition-based stats.
Identities = 962/978 (98%), Positives = 963/978 (98%)
Query: 42 MNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPP 101
MNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPP
Sbjct: 13 MNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPP 72
Query: 102 NIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGA 161
NIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGA
Sbjct: 73 NIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGA 132
Query: 162 LDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTG 221
LDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTG
Sbjct: 133 LDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTG 192
Query: 222 NKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENK 281
NKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENK
Sbjct: 193 NKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENK 252
Query: 282 NVXXXXXXXXXXXXXXXKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHE 341
NV KQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHE
Sbjct: 253 NVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHE 312
Query: 342 GPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKL 401
GPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKL
Sbjct: 313 GPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKL 372
Query: 402 RAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRP 461
RAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRP
Sbjct: 373 RAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRP 432
Query: 462 DLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGK 521
DLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGK
Sbjct: 433 DLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGK 492
Query: 522 FKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSP 581
FKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSP
Sbjct: 493 FKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSP 552
Query: 582 FAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPIL 641
FAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPIL
Sbjct: 553 FAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPIL 612
Query: 642 LKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELK 701
LKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELK
Sbjct: 613 LKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELK 672
Query: 702 EALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPS 761
EALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPS
Sbjct: 673 EALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPS 732
Query: 762 QLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFN 821
QLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFN
Sbjct: 733 QLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFN 792
Query: 822 TLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEA 881
TLRTKEQLG+IVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEA
Sbjct: 793 TLRTKEQLGFIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEA 852
Query: 882 FQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYK 941
FQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYK
Sbjct: 853 FQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYK 912
Query: 942 EMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRG 1001
EMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRG
Sbjct: 913 EMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRG 972
Query: 1002 LPLFPLVKPHINFMAAKL 1019
LPLFPLVKPHINFMAAKL
Sbjct: 973 LPLFPLVKPHINFMAAKL 990
>gi|118137776|pdb|2G47|A Chain A, Crystal Structure Of Human Insulin-Degrading Enzyme In
Complex With Amyloid-Beta (1-40)
gi|118137777|pdb|2G47|B Chain B, Crystal Structure Of Human Insulin-Degrading Enzyme In
Complex With Amyloid-Beta (1-40)
gi|118137780|pdb|2G48|A Chain A, Crystal Structure Of Human Insulin-Degrading Enzyme In
Complex With Amylin
gi|118137781|pdb|2G48|B Chain B, Crystal Structure Of Human Insulin-Degrading Enzyme In
Complex With Amylin
gi|118137784|pdb|2G49|A Chain A, Crystal Structure Of Human Insulin-Degrading Enzyme In
Complex With Glucagon
gi|118137785|pdb|2G49|B Chain B, Crystal Structure Of Human Insulin-Degrading Enzyme In
Complex With Glucagon
gi|118137792|pdb|2G54|A Chain A, Crystal Structure Of Zn-Bound Human Insulin-Degrading Enzyme
In Complex With Insulin B Chain
gi|118137793|pdb|2G54|B Chain B, Crystal Structure Of Zn-Bound Human Insulin-Degrading Enzyme
In Complex With Insulin B Chain
gi|118137796|pdb|2G56|A Chain A, Crystal Structure Of Human Insulin-Degrading Enzyme In
Complex With Insulin B Chain
gi|118137797|pdb|2G56|B Chain B, Crystal Structure Of Human Insulin-Degrading Enzyme In
Complex With Insulin B Chain
gi|151567697|pdb|2JBU|A Chain A, Crystal Structure Of Human Insulin Degrading Enzyme
Complexed With Co-Purified Peptides.
gi|151567698|pdb|2JBU|B Chain B, Crystal Structure Of Human Insulin Degrading Enzyme
Complexed With Co-Purified Peptides.
Length = 990
Score = 1959 bits (5076), Expect = 0.0, Method: Composition-based stats.
Identities = 962/978 (98%), Positives = 963/978 (98%)
Query: 42 MNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPP 101
MNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPP
Sbjct: 13 MNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPP 72
Query: 102 NIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGA 161
NIAGLSHFC+HMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGA
Sbjct: 73 NIAGLSHFCQHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGA 132
Query: 162 LDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTG 221
LDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTG
Sbjct: 133 LDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTG 192
Query: 222 NKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENK 281
NKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENK
Sbjct: 193 NKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENK 252
Query: 282 NVXXXXXXXXXXXXXXXKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHE 341
NV KQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHE
Sbjct: 253 NVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHE 312
Query: 342 GPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKL 401
GPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKL
Sbjct: 313 GPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKL 372
Query: 402 RAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRP 461
RAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRP
Sbjct: 373 RAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRP 432
Query: 462 DLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGK 521
DLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGK
Sbjct: 433 DLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGK 492
Query: 522 FKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSP 581
FKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSP
Sbjct: 493 FKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSP 552
Query: 582 FAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPIL 641
FAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPIL
Sbjct: 553 FAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPIL 612
Query: 642 LKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELK 701
LKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELK
Sbjct: 613 LKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELK 672
Query: 702 EALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPS 761
EALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPS
Sbjct: 673 EALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPS 732
Query: 762 QLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFN 821
QLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFN
Sbjct: 733 QLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFN 792
Query: 822 TLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEA 881
TLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEA
Sbjct: 793 TLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEA 852
Query: 882 FQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYK 941
FQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYK
Sbjct: 853 FQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYK 912
Query: 942 EMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRG 1001
EMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRG
Sbjct: 913 EMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRG 972
Query: 1002 LPLFPLVKPHINFMAAKL 1019
LPLFPLVKPHINFMAAKL
Sbjct: 973 LPLFPLVKPHINFMAAKL 990
>gi|114631808|ref|XP_001146520.1| PREDICTED: insulysin isoform 2 [Pan troglodytes]
gi|119570478|gb|EAW50093.1| insulin-degrading enzyme, isoform CRA_c [Homo sapiens]
Length = 978
Score = 1957 bits (5071), Expect = 0.0, Method: Composition-based stats.
Identities = 963/978 (98%), Positives = 963/978 (98%)
Query: 42 MNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPP 101
MNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPP
Sbjct: 1 MNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPP 60
Query: 102 NIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGA 161
NIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGA
Sbjct: 61 NIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGA 120
Query: 162 LDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTG 221
LDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTG
Sbjct: 121 LDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTG 180
Query: 222 NKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENK 281
NKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENK
Sbjct: 181 NKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENK 240
Query: 282 NVXXXXXXXXXXXXXXXKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHE 341
NV KQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHE
Sbjct: 241 NVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHE 300
Query: 342 GPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKL 401
GPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKL
Sbjct: 301 GPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKL 360
Query: 402 RAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRP 461
RAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRP
Sbjct: 361 RAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRP 420
Query: 462 DLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGK 521
DLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGK
Sbjct: 421 DLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGK 480
Query: 522 FKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSP 581
FKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSP
Sbjct: 481 FKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSP 540
Query: 582 FAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPIL 641
FAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPIL
Sbjct: 541 FAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPIL 600
Query: 642 LKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELK 701
LKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELK
Sbjct: 601 LKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELK 660
Query: 702 EALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPS 761
EALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPS
Sbjct: 661 EALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPS 720
Query: 762 QLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFN 821
QLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFN
Sbjct: 721 QLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFN 780
Query: 822 TLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEA 881
TLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEA
Sbjct: 781 TLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEA 840
Query: 882 FQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYK 941
FQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYK
Sbjct: 841 FQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYK 900
Query: 942 EMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRG 1001
EMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRG
Sbjct: 901 EMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRG 960
Query: 1002 LPLFPLVKPHINFMAAKL 1019
LPLFPLVKPHINFMAAKL
Sbjct: 961 LPLFPLVKPHINFMAAKL 978
>gi|14548072|sp|Q9JHR7|IDE_MOUSE Insulin-degrading enzyme (Insulysin) (Insulinase) (Insulin protease)
gi|9663735|emb|CAC01233.1| insulin degrading enzyme [Mus musculus]
Length = 1019
Score = 1955 bits (5064), Expect = 0.0, Method: Composition-based stats.
Identities = 953/1019 (93%), Positives = 978/1019 (95%)
Query: 1 MRYRLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED 60
MR L WLLHPALP T RS+LGAR PP +RLCGF K+TYS M+NPAI+RI + I KSPED
Sbjct: 1 MRNGLVWLLHPALPGTLRSILGARPPPAKRLCGFPKQTYSTMSNPAIQRIEDQIVKSPED 60
Query: 61 KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK 120
KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNI GLSHFCEHMLFLGTKK
Sbjct: 61 KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIPGLSHFCEHMLFLGTKK 120
Query: 121 YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD 180
YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPL D SCKD
Sbjct: 121 YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLLDASCKD 180
Query: 181 REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE 240
REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVR+E
Sbjct: 181 REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVREE 240
Query: 241 LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVXXXXXXXXXXXXXXXKQ 300
LLKFHS YYSSNLMA+CVLGRESLDDLTNLVVKLFSEVENKNV +Q
Sbjct: 241 LLKFHSTYYSSNLMAICVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLRQ 300
Query: 301 LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV 360
LYKIVPIKDIRNLYVTFPIPDLQ+YYKSNPG+YLGHLIGHEGPGSLLSELKSKGWVNTLV
Sbjct: 301 LYKIVPIKDIRNLYVTFPIPDLQQYYKSNPGYYLGHLIGHEGPGSLLSELKSKGWVNTLV 360
Query: 361 GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 420
GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV
Sbjct: 361 GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 420
Query: 421 AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI 480
AFRFKDKERPRGYTSKIAG LHYYPL VLTAEYLLEEFRPDLI+MVLDKLRPENVRVAI
Sbjct: 421 AFRFKDKERPRGYTSKIAGKLHYYPLNGVLTAEYLLEEFRPDLIDMVLDKLRPENVRVAI 480
Query: 481 VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL 540
VSKSFEGKTDRTE+WYGTQYKQEAIP++VI+KWQNADLNGKFKLPTKNEFIPTNFEIL L
Sbjct: 481 VSKSFEGKTDRTEQWYGTQYKQEAIPEDVIQKWQNADLNGKFKLPTKNEFIPTNFEILSL 540
Query: 541 EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL 600
EK+ATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL
Sbjct: 541 EKDATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL 600
Query: 601 KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE 660
KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVK YNDKQPILLKKI EKMATFEID+KRFE
Sbjct: 601 KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKRYNDKQPILLKKITEKMATFEIDKKRFE 660
Query: 661 IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 720
IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL
Sbjct: 661 IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 720
Query: 721 SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 780
SRLHIEALLHGNITKQAALG+MQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ
Sbjct: 721 SRLHIEALLHGNITKQAALGVMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 780
Query: 781 QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 840
QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA
Sbjct: 781 QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 840
Query: 841 NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL 900
NGIQGLRFIIQSEKPPHYLESRVEAFLITMEK+IEDMTEEAFQKHIQALAIRRLDKPKKL
Sbjct: 841 NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKAIEDMTEEAFQKHIQALAIRRLDKPKKL 900
Query: 901 SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA 960
SAECAKYWGEIISQQYN+DRDN EVAYLKTLTK+DII+FY+EMLAVDAPRRHKVSVHVLA
Sbjct: 901 SAECAKYWGEIISQQYNYDRDNIEVAYLKTLTKDDIIRFYQEMLAVDAPRRHKVSVHVLA 960
Query: 961 REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL 1019
REMDSCPVVGEFP QNDINLS+AP LPQPEVI NMTEFKRGLPLFPLVKPHINFMAAKL
Sbjct: 961 REMDSCPVVGEFPSQNDINLSEAPPLPQPEVIHNMTEFKRGLPLFPLVKPHINFMAAKL 1019
>gi|73998234|ref|XP_534963.2| PREDICTED: similar to Insulin-degrading enzyme (Insulysin)
(Insulinase) (Insulin protease) [Canis familiaris]
Length = 994
Score = 1952 bits (5058), Expect = 0.0, Method: Composition-based stats.
Identities = 965/1019 (94%), Positives = 971/1019 (95%), Gaps = 25/1019 (2%)
Query: 1 MRYRLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED 60
MRY LAWLLH A PSTFRSVLGARLP PERLCGFQ+K+YSKMNNPAIKR+GNHI KSPED
Sbjct: 1 MRYPLAWLLHSARPSTFRSVLGARLPLPERLCGFQEKSYSKMNNPAIKRLGNHIIKSPED 60
Query: 61 KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK 120
KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK
Sbjct: 61 KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK 120
Query: 121 YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD 180
YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD
Sbjct: 121 YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD 180
Query: 181 REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE 240
REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE
Sbjct: 181 REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE 240
Query: 241 LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVXXXXXXXXXXXXXXXKQ 300
LLKFHS YYSSNLMA+CVLGRESLDDLTNLVVKLFSEVENKNV KQ
Sbjct: 241 LLKFHSTYYSSNLMAICVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ 300
Query: 301 LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV 360
LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV
Sbjct: 301 LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV 360
Query: 361 GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 420
GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV
Sbjct: 361 GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 420
Query: 421 AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI 480
AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI
Sbjct: 421 AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI 480
Query: 481 VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL 540
VSKSFEGKTDRTEEWYGTQYKQEA+PDEVIK IL L
Sbjct: 481 VSKSFEGKTDRTEEWYGTQYKQEAVPDEVIK-------------------------ILSL 515
Query: 541 EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL 600
EKEA PYP+LIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL
Sbjct: 516 EKEAHPYPSLIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL 575
Query: 601 KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE 660
KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE
Sbjct: 576 KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE 635
Query: 661 IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 720
IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL
Sbjct: 636 IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 695
Query: 721 SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 780
SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ
Sbjct: 696 SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 755
Query: 781 QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 840
QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA
Sbjct: 756 QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 815
Query: 841 NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL 900
NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL
Sbjct: 816 NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL 875
Query: 901 SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA 960
SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA
Sbjct: 876 SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA 935
Query: 961 REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL 1019
REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL
Sbjct: 936 REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL 994
>gi|109089938|ref|XP_001090137.1| PREDICTED: insulysin isoform 2 [Macaca mulatta]
Length = 978
Score = 1951 bits (5055), Expect = 0.0, Method: Composition-based stats.
Identities = 959/978 (98%), Positives = 962/978 (98%)
Query: 42 MNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPP 101
MNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPP
Sbjct: 1 MNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPP 60
Query: 102 NIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGA 161
NIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGA
Sbjct: 61 NIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGA 120
Query: 162 LDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTG 221
LDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTG
Sbjct: 121 LDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTG 180
Query: 222 NKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENK 281
NKYTLETRPNQEGIDVRQELLKFHS YYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENK
Sbjct: 181 NKYTLETRPNQEGIDVRQELLKFHSTYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENK 240
Query: 282 NVXXXXXXXXXXXXXXXKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHE 341
+V KQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHE
Sbjct: 241 SVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHE 300
Query: 342 GPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKL 401
GPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKL
Sbjct: 301 GPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKL 360
Query: 402 RAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRP 461
RAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRP
Sbjct: 361 RAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRP 420
Query: 462 DLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGK 521
DLIEMVLDKLRPENVRVA+VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGK
Sbjct: 421 DLIEMVLDKLRPENVRVAVVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGK 480
Query: 522 FKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSP 581
FKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSP
Sbjct: 481 FKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSP 540
Query: 582 FAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPIL 641
FAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPIL
Sbjct: 541 FAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPIL 600
Query: 642 LKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELK 701
LKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELK
Sbjct: 601 LKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELK 660
Query: 702 EALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPS 761
EALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPS
Sbjct: 661 EALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPS 720
Query: 762 QLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFN 821
QLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFN
Sbjct: 721 QLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFN 780
Query: 822 TLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEA 881
TLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEA
Sbjct: 781 TLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEA 840
Query: 882 FQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYK 941
FQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQY+FDRDNTEVAYLKTLTKEDIIKFYK
Sbjct: 841 FQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYHFDRDNTEVAYLKTLTKEDIIKFYK 900
Query: 942 EMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRG 1001
EMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRG
Sbjct: 901 EMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRG 960
Query: 1002 LPLFPLVKPHINFMAAKL 1019
LPLFPLVKPHINFMAAKL
Sbjct: 961 LPLFPLVKPHINFMAAKL 978
>gi|149631907|ref|XP_001506502.1| PREDICTED: similar to insulin-degrading enzyme [Ornithorhynchus
anatinus]
Length = 1301
Score = 1922 bits (4979), Expect = 0.0, Method: Composition-based stats.
Identities = 924/986 (93%), Positives = 950/986 (96%)
Query: 34 FQKKTYSKMNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVH 93
FQ+ +Y KM++ A+KRI N+I KSPEDKREYRGLELANGIK +LISDPTTDKSSAALDVH
Sbjct: 316 FQRYSYGKMDHSAVKRIVNNIIKSPEDKREYRGLELANGIKAILISDPTTDKSSAALDVH 375
Query: 94 IGSLSDPPNIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDV 153
IGSLSDPPNIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDV
Sbjct: 376 IGSLSDPPNIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDV 435
Query: 154 SHEHLEGALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKH 213
SHEHLEGALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNP H
Sbjct: 436 SHEHLEGALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPNH 495
Query: 214 PFSKFGTGNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVK 273
PFSKFGTGNKYTLETRP +EGIDVRQELLKFHS YYSSNLMA+CVLGRESLD+LT+LVVK
Sbjct: 496 PFSKFGTGNKYTLETRPTKEGIDVRQELLKFHSTYYSSNLMAICVLGRESLDELTSLVVK 555
Query: 274 LFSEVENKNVXXXXXXXXXXXXXXXKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHY 333
LFSEVENKNV +Q+YK+VPIKDIRNLYVTFPIPDLQKYYKSNPGHY
Sbjct: 556 LFSEVENKNVPLPEFPEHPFQEHHLRQIYKVVPIKDIRNLYVTFPIPDLQKYYKSNPGHY 615
Query: 334 LGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILH 393
LGHLIGHEGPGSLLSELK+KGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILH
Sbjct: 616 LGHLIGHEGPGSLLSELKAKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILH 675
Query: 394 MFQYIQKLRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAE 453
MFQYIQKLR EGPQEWVFQECKDLNAVAFRFKDKERPRGYTSK+ G+LHYYPLEEVL AE
Sbjct: 676 MFQYIQKLRTEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKLGGMLHYYPLEEVLAAE 735
Query: 454 YLLEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKW 513
YLLEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTD+TEEWYGTQYKQEAI DEVIKKW
Sbjct: 736 YLLEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDQTEEWYGTQYKQEAISDEVIKKW 795
Query: 514 QNADLNGKFKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKAC 573
QNADLNGKFKLP KNEFIP+NFEIL LEKEA YPALIKDTAMSKLWFKQDDKFFLPKAC
Sbjct: 796 QNADLNGKFKLPMKNEFIPSNFEILQLEKEAPSYPALIKDTAMSKLWFKQDDKFFLPKAC 855
Query: 574 LNFEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKG 633
LNFEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKG
Sbjct: 856 LNFEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKG 915
Query: 634 YNDKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEV 693
YNDKQPILLKKI+EKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEV
Sbjct: 916 YNDKQPILLKKIVEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEV 975
Query: 694 AWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHA 753
AWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALG+MQMVEDTLIEHA
Sbjct: 976 AWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGVMQMVEDTLIEHA 1035
Query: 754 HTKPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQ 813
HTKPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQ
Sbjct: 1036 HTKPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQ 1095
Query: 814 IISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKS 873
IISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKS
Sbjct: 1096 IISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKS 1155
Query: 874 IEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTK 933
IEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTK
Sbjct: 1156 IEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTK 1215
Query: 934 EDIIKFYKEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQ 993
EDII+FYKEMLAV+APRRHKVSVHVLAREMDSCPVVGEFPCQND+NL+ APALPQPEVI+
Sbjct: 1216 EDIIRFYKEMLAVEAPRRHKVSVHVLAREMDSCPVVGEFPCQNDVNLAAAPALPQPEVIE 1275
Query: 994 NMTEFKRGLPLFPLVKPHINFMAAKL 1019
NMT FKR LPLFPLVKPHIN MAAKL
Sbjct: 1276 NMTAFKRSLPLFPLVKPHINLMAAKL 1301
>gi|148709839|gb|EDL41785.1| insulin degrading enzyme [Mus musculus]
Length = 978
Score = 1898 bits (4917), Expect = 0.0, Method: Composition-based stats.
Identities = 926/978 (94%), Positives = 948/978 (96%)
Query: 42 MNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPP 101
M+NPAI+RI + I KSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPP
Sbjct: 1 MSNPAIQRIEDQIVKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPP 60
Query: 102 NIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGA 161
NI GLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGA
Sbjct: 61 NIPGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGA 120
Query: 162 LDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTG 221
LDRFAQFFLCPLFD SCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTG
Sbjct: 121 LDRFAQFFLCPLFDASCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTG 180
Query: 222 NKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENK 281
NKYTLETRPNQEGIDVR+ELLKFHS YYSSNLMA+CVLGRESLDDLTNLVVKLFSEVENK
Sbjct: 181 NKYTLETRPNQEGIDVREELLKFHSTYYSSNLMAICVLGRESLDDLTNLVVKLFSEVENK 240
Query: 282 NVXXXXXXXXXXXXXXXKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHE 341
NV +QLYKIVPIKDIRNLYVTFPIPDLQ+YYKSNPGHYLGHLIGHE
Sbjct: 241 NVPLPEFPEHPFQEEHLRQLYKIVPIKDIRNLYVTFPIPDLQQYYKSNPGHYLGHLIGHE 300
Query: 342 GPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKL 401
GPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKL
Sbjct: 301 GPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKL 360
Query: 402 RAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRP 461
RAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAG LHYYPL VLTAEYLLEEFRP
Sbjct: 361 RAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGKLHYYPLNGVLTAEYLLEEFRP 420
Query: 462 DLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGK 521
DLI+MVLDKLRPENVRVAIVSKSFEGKTDRTE+WYGTQYKQEAIP+++I+KWQNADLNGK
Sbjct: 421 DLIDMVLDKLRPENVRVAIVSKSFEGKTDRTEQWYGTQYKQEAIPEDIIQKWQNADLNGK 480
Query: 522 FKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSP 581
FKLPTKNEFIPTNFEIL LEK+ATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSP
Sbjct: 481 FKLPTKNEFIPTNFEILSLEKDATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSP 540
Query: 582 FAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPIL 641
FAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPIL
Sbjct: 541 FAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPIL 600
Query: 642 LKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELK 701
LKKI EKMATFEID+KRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELK
Sbjct: 601 LKKITEKMATFEIDKKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELK 660
Query: 702 EALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPS 761
EALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALG+MQMVEDTLIEHAHTKPLLPS
Sbjct: 661 EALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGVMQMVEDTLIEHAHTKPLLPS 720
Query: 762 QLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFN 821
QLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFN
Sbjct: 721 QLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFN 780
Query: 822 TLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEA 881
TLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEK+IEDMTEEA
Sbjct: 781 TLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKAIEDMTEEA 840
Query: 882 FQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYK 941
FQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYN+DRDN EVAYLKTLTK+DII+FY+
Sbjct: 841 FQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNYDRDNIEVAYLKTLTKDDIIRFYQ 900
Query: 942 EMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRG 1001
EMLAVDAPRRHKVSVHVLAREMDSCPVVGEFP QNDINLS+AP LPQPEVI NMTEFKRG
Sbjct: 901 EMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPSQNDINLSEAPPLPQPEVIHNMTEFKRG 960
Query: 1002 LPLFPLVKPHINFMAAKL 1019
LPLFPLVKPHINFMAAKL
Sbjct: 961 LPLFPLVKPHINFMAAKL 978
>gi|148238275|ref|NP_001082994.1| insulin-degrading enzyme [Danio rerio]
gi|141796249|gb|AAI39608.1| Zgc:162603 protein [Danio rerio]
Length = 978
Score = 1800 bits (4661), Expect = 0.0, Method: Composition-based stats.
Identities = 860/978 (87%), Positives = 923/978 (94%)
Query: 42 MNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPP 101
M++PA+KR+ + I +SPEDKREYRGLE NG+K +LISDPTTDKSSAALDVH+GSLSDP
Sbjct: 1 MSDPAVKRVVSDIIRSPEDKREYRGLEFTNGLKAILISDPTTDKSSAALDVHMGSLSDPE 60
Query: 102 NIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGA 161
NI+GL+HFCEHMLFLGT+KYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHL+GA
Sbjct: 61 NISGLAHFCEHMLFLGTEKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLQGA 120
Query: 162 LDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTG 221
LDRFAQFFLCPLFDESCKDREVNAVDSEHEKN+MNDAWRLFQLEKATGNPKHPFSKFGTG
Sbjct: 121 LDRFAQFFLCPLFDESCKDREVNAVDSEHEKNLMNDAWRLFQLEKATGNPKHPFSKFGTG 180
Query: 222 NKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENK 281
NK TLETRP+Q+GID+R+ELLKFHS YYSSNLM +CVLGRE+LD+LT++VVKLF EVENK
Sbjct: 181 NKLTLETRPSQQGIDIREELLKFHSTYYSSNLMGLCVLGRETLDELTSMVVKLFGEVENK 240
Query: 282 NVXXXXXXXXXXXXXXXKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHE 341
NV +Q YK+VPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHE
Sbjct: 241 NVPVPEFPTHPFQEEHLRQFYKVVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHE 300
Query: 342 GPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKL 401
GPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDII HMFQYIQKL
Sbjct: 301 GPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIIFHMFQYIQKL 360
Query: 402 RAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRP 461
R EGPQEWVFQECKDLN VAFRFKDKERPRGYTSK+AG+LHYYPLEE+L AEYLLEEFRP
Sbjct: 361 RTEGPQEWVFQECKDLNTVAFRFKDKERPRGYTSKVAGLLHYYPLEEILAAEYLLEEFRP 420
Query: 462 DLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGK 521
DLIEMVLDKLRPENVRVA+VSKSFEG+TDRTEEWYGTQYKQEAI DE IKKW NADLNGK
Sbjct: 421 DLIEMVLDKLRPENVRVAVVSKSFEGQTDRTEEWYGTQYKQEAITDEAIKKWDNADLNGK 480
Query: 522 FKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSP 581
FKLP KNEFIPTNFEI PLEK++ P LIKDTAMSK+WFKQDDKFFLPKACLNFEFFSP
Sbjct: 481 FKLPMKNEFIPTNFEIYPLEKDSPSAPTLIKDTAMSKVWFKQDDKFFLPKACLNFEFFSP 540
Query: 582 FAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPIL 641
FAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNT+YGMYLSVKGYNDKQ IL
Sbjct: 541 FAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTVYGMYLSVKGYNDKQHIL 600
Query: 642 LKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELK 701
LKKIIEKMATFEIDEKRF+IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDEL+
Sbjct: 601 LKKIIEKMATFEIDEKRFDIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELR 660
Query: 702 EALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPS 761
+ALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQ+AL +MQM+EDTLIEHAHTKPLLPS
Sbjct: 661 DALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQSALEMMQMLEDTLIEHAHTKPLLPS 720
Query: 762 QLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFN 821
QL+RYREVQ+PD GW+VYQQRNEVHNNCGIEIYYQTDMQ+T ENM LELFCQIISEPCFN
Sbjct: 721 QLIRYREVQVPDGGWYVYQQRNEVHNNCGIEIYYQTDMQNTHENMLLELFCQIISEPCFN 780
Query: 822 TLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEA 881
TLRTKEQLGYIVFSGPRRANG+QGLRFIIQSEK PHYLESRVEAFL TMEKS+E+M +EA
Sbjct: 781 TLRTKEQLGYIVFSGPRRANGVQGLRFIIQSEKAPHYLESRVEAFLKTMEKSVEEMGDEA 840
Query: 882 FQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYK 941
FQKHIQALAIRRLDKPKKL+AECAKYWGEIISQQYNFDRDN EVAYLKTLTKE I++FY+
Sbjct: 841 FQKHIQALAIRRLDKPKKLAAECAKYWGEIISQQYNFDRDNIEVAYLKTLTKEHIMQFYR 900
Query: 942 EMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRG 1001
++LA+DAPRRHKVSVHVL+REMDSCP+VGEFP QND+NL+ AP+LPQP ++Q+MTEFKR
Sbjct: 901 DLLAIDAPRRHKVSVHVLSREMDSCPLVGEFPAQNDVNLAPAPSLPQPSLVQDMTEFKRS 960
Query: 1002 LPLFPLVKPHINFMAAKL 1019
LPLFPL KPHINFMAAKL
Sbjct: 961 LPLFPLTKPHINFMAAKL 978
>gi|146455165|dbj|BAF62161.1| insulin-degrading enzyme [Danio rerio]
Length = 998
Score = 1798 bits (4656), Expect = 0.0, Method: Composition-based stats.
Identities = 858/979 (87%), Positives = 922/979 (94%)
Query: 41 KMNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDP 100
+M++PA+KR+ + I +SPEDKREYRGLE NG+K +LISDPTTDKSSAALDVH+GSLSDP
Sbjct: 20 RMSDPAVKRVVSDIIRSPEDKREYRGLESTNGLKAILISDPTTDKSSAALDVHMGSLSDP 79
Query: 101 PNIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEG 160
NI+GL+HFCEHMLFLGT+KYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHL+G
Sbjct: 80 ENISGLAHFCEHMLFLGTEKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLQG 139
Query: 161 ALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGT 220
ALDRFAQFFLCPLFDESCKDREVNAVDSEHEKN+MNDAWRLFQLEKATGNPKHPFSKFGT
Sbjct: 140 ALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNLMNDAWRLFQLEKATGNPKHPFSKFGT 199
Query: 221 GNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVEN 280
GNK TLETRP+Q+GID+R+ELLKFHS YYSSNLM +CVLGRE+LD+LT++VVKLF EVEN
Sbjct: 200 GNKLTLETRPSQQGIDIREELLKFHSTYYSSNLMGLCVLGRETLDELTSMVVKLFGEVEN 259
Query: 281 KNVXXXXXXXXXXXXXXXKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGH 340
KNV +Q YK+VPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGH
Sbjct: 260 KNVPVPEFPTHPFQEEHLRQFYKVVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGH 319
Query: 341 EGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQK 400
EGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDII HMFQYIQK
Sbjct: 320 EGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIIFHMFQYIQK 379
Query: 401 LRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFR 460
LR EGPQEWVFQECKDLN VAFRFKDKERPRGYTSK+AG+LHYYPLEE+L AEYLLEEFR
Sbjct: 380 LRTEGPQEWVFQECKDLNTVAFRFKDKERPRGYTSKVAGLLHYYPLEEILAAEYLLEEFR 439
Query: 461 PDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNG 520
PDLIEMVLDKLRPENVRVA+VSKSFEG+TDRTEEWYGTQYKQEAI DE IKKW NADLNG
Sbjct: 440 PDLIEMVLDKLRPENVRVAVVSKSFEGQTDRTEEWYGTQYKQEAITDEAIKKWDNADLNG 499
Query: 521 KFKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFS 580
KFKLP KNEFIPTNFEI PLEK++ P LIKDTAMSK+WFKQDDKFFLPKACLNFEFFS
Sbjct: 500 KFKLPMKNEFIPTNFEIYPLEKDSPSAPTLIKDTAMSKVWFKQDDKFFLPKACLNFEFFS 559
Query: 581 PFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPI 640
PFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNT+YGMYLSVKGYNDKQ I
Sbjct: 560 PFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTVYGMYLSVKGYNDKQHI 619
Query: 641 LLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDEL 700
LLKKIIEKMATFEIDEKRF+IIKEAYMR LNNFRAEQPHQHAMYYLRLLMTEVAWTKDEL
Sbjct: 620 LLKKIIEKMATFEIDEKRFDIIKEAYMRPLNNFRAEQPHQHAMYYLRLLMTEVAWTKDEL 679
Query: 701 KEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLP 760
++ALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQ+AL +MQM+EDTLIEHAHTKPLLP
Sbjct: 680 RDALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQSALEMMQMLEDTLIEHAHTKPLLP 739
Query: 761 SQLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCF 820
SQL+RYREVQ+PD GW+VYQQRNEVHNNCGIEIYYQTDMQ+T ENM LELFCQIISEPCF
Sbjct: 740 SQLIRYREVQVPDGGWYVYQQRNEVHNNCGIEIYYQTDMQNTHENMLLELFCQIISEPCF 799
Query: 821 NTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEE 880
NTLRTKEQLGYIVFSGPRRANG+QGLRFIIQSEK PHYLESRVEAFL TMEKS+E+M +E
Sbjct: 800 NTLRTKEQLGYIVFSGPRRANGVQGLRFIIQSEKAPHYLESRVEAFLKTMEKSVEEMGDE 859
Query: 881 AFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFY 940
AFQKHIQALAIRRLDKPKKL+AECAKYWGEIISQQYNFDRDN EVAYLKTLTKE I++FY
Sbjct: 860 AFQKHIQALAIRRLDKPKKLAAECAKYWGEIISQQYNFDRDNIEVAYLKTLTKEHIMQFY 919
Query: 941 KEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKR 1000
+++LA+DAPRRHKVSVHVL+REMDSCP+VGEFP QND+NL+ AP+LPQP ++Q+MTEFKR
Sbjct: 920 RDLLAIDAPRRHKVSVHVLSREMDSCPLVGEFPAQNDVNLAPAPSLPQPSLVQDMTEFKR 979
Query: 1001 GLPLFPLVKPHINFMAAKL 1019
LPLFPL KPHINFMAA L
Sbjct: 980 SLPLFPLTKPHINFMAANL 998
>gi|114631810|ref|XP_001146439.1| PREDICTED: insulysin isoform 1 [Pan troglodytes]
Length = 861
Score = 1707 bits (4420), Expect = 0.0, Method: Composition-based stats.
Identities = 841/856 (98%), Positives = 841/856 (98%)
Query: 164 RFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNK 223
RFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNK
Sbjct: 6 RFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNK 65
Query: 224 YTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNV 283
YTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNV
Sbjct: 66 YTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNV 125
Query: 284 XXXXXXXXXXXXXXXKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGP 343
KQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGP
Sbjct: 126 PLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGP 185
Query: 344 GSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRA 403
GSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRA
Sbjct: 186 GSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRA 245
Query: 404 EGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDL 463
EGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDL
Sbjct: 246 EGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDL 305
Query: 464 IEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFK 523
IEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFK
Sbjct: 306 IEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFK 365
Query: 524 LPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFA 583
LPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFA
Sbjct: 366 LPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFA 425
Query: 584 YVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLK 643
YVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLK
Sbjct: 426 YVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLK 485
Query: 644 KIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEA 703
KIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEA
Sbjct: 486 KIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEA 545
Query: 704 LDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQL 763
LDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQL
Sbjct: 546 LDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQL 605
Query: 764 VRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTL 823
VRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTL
Sbjct: 606 VRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTL 665
Query: 824 RTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQ 883
RTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQ
Sbjct: 666 RTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQ 725
Query: 884 KHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEM 943
KHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEM
Sbjct: 726 KHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEM 785
Query: 944 LAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLP 1003
LAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLP
Sbjct: 786 LAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLP 845
Query: 1004 LFPLVKPHINFMAAKL 1019
LFPLVKPHINFMAAKL
Sbjct: 846 LFPLVKPHINFMAAKL 861
>gi|109089940|ref|XP_001090017.1| PREDICTED: insulysin isoform 1 [Macaca mulatta]
Length = 861
Score = 1701 bits (4404), Expect = 0.0, Method: Composition-based stats.
Identities = 837/856 (97%), Positives = 840/856 (98%)
Query: 164 RFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNK 223
RFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNK
Sbjct: 6 RFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNK 65
Query: 224 YTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNV 283
YTLETRPNQEGIDVRQELLKFHS YYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENK+V
Sbjct: 66 YTLETRPNQEGIDVRQELLKFHSTYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKSV 125
Query: 284 XXXXXXXXXXXXXXXKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGP 343
KQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGP
Sbjct: 126 PLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGP 185
Query: 344 GSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRA 403
GSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRA
Sbjct: 186 GSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRA 245
Query: 404 EGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDL 463
EGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDL
Sbjct: 246 EGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDL 305
Query: 464 IEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFK 523
IEMVLDKLRPENVRVA+VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFK
Sbjct: 306 IEMVLDKLRPENVRVAVVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFK 365
Query: 524 LPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFA 583
LPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFA
Sbjct: 366 LPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFA 425
Query: 584 YVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLK 643
YVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLK
Sbjct: 426 YVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLK 485
Query: 644 KIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEA 703
KIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEA
Sbjct: 486 KIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEA 545
Query: 704 LDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQL 763
LDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQL
Sbjct: 546 LDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQL 605
Query: 764 VRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTL 823
VRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTL
Sbjct: 606 VRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTL 665
Query: 824 RTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQ 883
RTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQ
Sbjct: 666 RTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQ 725
Query: 884 KHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEM 943
KHIQALAIRRLDKPKKLSAECAKYWGEIISQQY+FDRDNTEVAYLKTLTKEDIIKFYKEM
Sbjct: 726 KHIQALAIRRLDKPKKLSAECAKYWGEIISQQYHFDRDNTEVAYLKTLTKEDIIKFYKEM 785
Query: 944 LAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLP 1003
LAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLP
Sbjct: 786 LAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLP 845
Query: 1004 LFPLVKPHINFMAAKL 1019
LFPLVKPHINFMAAKL
Sbjct: 846 LFPLVKPHINFMAAKL 861
>gi|62087988|dbj|BAD92441.1| insulysin variant [Homo sapiens]
Length = 594
Score = 1202 bits (3111), Expect = 0.0, Method: Composition-based stats.
Identities = 593/594 (99%), Positives = 593/594 (99%)
Query: 426 DKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAIVSKSF 485
DKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAIVSK F
Sbjct: 1 DKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAIVSKCF 60
Query: 486 EGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPLEKEAT 545
EGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPLEKEAT
Sbjct: 61 EGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPLEKEAT 120
Query: 546 PYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELLKDSLN 605
PYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELLKDSLN
Sbjct: 121 PYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELLKDSLN 180
Query: 606 EYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFEIIKEA 665
EYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFEIIKEA
Sbjct: 181 EYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFEIIKEA 240
Query: 666 YMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHI 725
YMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHI
Sbjct: 241 YMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHI 300
Query: 726 EALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQRNEV 785
EALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQRNEV
Sbjct: 301 EALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQRNEV 360
Query: 786 HNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRANGIQG 845
HNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRANGIQG
Sbjct: 361 HNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRANGIQG 420
Query: 846 LRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKLSAECA 905
LRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKLSAECA
Sbjct: 421 LRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKLSAECA 480
Query: 906 KYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLAREMDS 965
KYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLAREMDS
Sbjct: 481 KYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLAREMDS 540
Query: 966 CPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL 1019
CPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL
Sbjct: 541 CPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL 594
>gi|156374406|ref|XP_001629798.1| predicted protein [Nematostella vectensis]
gi|156216806|gb|EDO37735.1| predicted protein [Nematostella vectensis]
Length = 947
Score = 1165 bits (3013), Expect = 0.0, Method: Composition-based stats.
Identities = 550/914 (60%), Positives = 698/914 (76%), Gaps = 16/914 (1%)
Query: 46 AIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAG 105
+K + I KSP+D R+YRGL L NG+KVLLI D +TDKS+AA+DVHIGSL+DP + G
Sbjct: 3 GVKEVHKDIPKSPQDDRDYRGLLLENGLKVLLIHDSSTDKSAAAMDVHIGSLTDPKELPG 62
Query: 106 LSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRF 165
L+HFCEHMLFLGT+KYP EN Y+QFL+E+ GSSNAFTSGEHTNY+FDV +E L ALDRF
Sbjct: 63 LAHFCEHMLFLGTEKYPGENAYTQFLTENGGSSNAFTSGEHTNYFFDVKYESLSNALDRF 122
Query: 166 AQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYT 225
AQFFLCPLF+ KDREVNAVDSE+ KN +ND WRL QL+K+T +P HP++KF TGNK T
Sbjct: 123 AQFFLCPLFNADAKDREVNAVDSENSKNRLNDMWRLNQLDKSTVDPSHPYNKFCTGNKLT 182
Query: 226 LETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVXX 285
L+TRP ++GID R+ELLKFHS YYS+N+M++ V+GRESLD++T +VVKLFS V+NKNV
Sbjct: 183 LDTRPKEKGIDTREELLKFHSLYYSANIMSLSVIGRESLDEMTEMVVKLFSPVQNKNVTI 242
Query: 286 XXXXXXXXXXXXXKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGS 345
+ L+K+VP+KD++NL + FPIPD+ KYY P HY+ HLIGHEG GS
Sbjct: 243 PTFPEHPYGAEQVQTLFKVVPVKDMKNLNLMFPIPDMSKYYHFKPSHYISHLIGHEGEGS 302
Query: 346 LLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEG 405
LLSELK+KGWVN LV G +GA+GFMFF+ N++LT EG H+ +I +FQY++ LR E
Sbjct: 303 LLSELKAKGWVNALVAGALDGAKGFMFFMCNMELTNEGQDHIFEISTSVFQYLEMLRREE 362
Query: 406 PQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIE 465
P EWVF+ECK L V FRF DKE PR Y +A LH + +++VL +LL FRPDLI+
Sbjct: 363 PFEWVFEECKALAEVRFRFNDKETPRSYVCHLARSLHDFSIDDVLRGPHLLTSFRPDLIK 422
Query: 466 MVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLP 525
VLD L PE VR+ IVSK+FEGKTD+TEEWYGT+Y E I + IK W+N LN +P
Sbjct: 423 QVLDNLVPEKVRITIVSKAFEGKTDKTEEWYGTEYSMERIDQQQIKDWKNVSLNAALTIP 482
Query: 526 TKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYV 585
KNEFIPT+ +I P E +P ++K+WFKQD F LPKAC+ FE SP AY+
Sbjct: 483 KKNEFIPTDLDIRPAPGEDSP---------LTKVWFKQDVTFLLPKACMLFEITSPLAYI 533
Query: 586 DPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKI 645
DP HCNMAY++L+LLKDSLNEYAY AE+AG++Y+L NT+YG+++S++GYN KQ IL++KI
Sbjct: 534 DPCHCNMAYIFLQLLKDSLNEYAYDAEIAGVTYNLDNTMYGIFMSIRGYNHKQGILMEKI 593
Query: 646 IEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALD 705
+++M F++D RF +IKE Y + L NF+AEQPHQHA+YY L+ E+AW KDEL +AL+
Sbjct: 594 LKRMTKFKVDPNRFRLIKERYEQGLRNFKAEQPHQHALYYTSYLLEELAWHKDELIDALE 653
Query: 706 DVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVR 765
+VT+ +L+AFIPQLL RLHIE LLHGN+T++ ALG++ +E E++ TKPLLP QL R
Sbjct: 654 EVTIEKLQAFIPQLLGRLHIECLLHGNVTEKEALGLVDTMESIFTENSGTKPLLPLQLRR 713
Query: 766 YREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRT 825
+RE+QLP N VH+N IEIYYQ D+Q T NM LELFCQ+I E CFN LRT
Sbjct: 714 HREIQLP-------HTVNHVHSNSSIEIYYQCDLQETRSNMLLELFCQVIHESCFNILRT 766
Query: 826 KEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKH 885
+EQLGYIVFSGPRR NG QGLRFIIQS+K P L+SRVE FL ++ IE MT+E F+ H
Sbjct: 767 QEQLGYIVFSGPRRGNGAQGLRFIIQSDKEPSLLDSRVEVFLDKTKEMIESMTDEEFKNH 826
Query: 886 IQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLA 945
I ALA+RRLDKPKKL E K+WGEI+++QYNFDRDN EVA+L+TLTK+D++ FYK++L
Sbjct: 827 IDALAVRRLDKPKKLRTETQKHWGEILTRQYNFDRDNVEVAFLRTLTKDDLLNFYKDLLE 886
Query: 946 VDAPRRHKVSVHVL 959
APRRHK++VH+L
Sbjct: 887 PSAPRRHKLAVHIL 900
>gi|119570477|gb|EAW50092.1| insulin-degrading enzyme, isoform CRA_b [Homo sapiens]
Length = 568
Score = 1077 bits (2786), Expect = 0.0, Method: Composition-based stats.
Identities = 524/539 (97%), Positives = 524/539 (97%)
Query: 42 MNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPP 101
MNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPP
Sbjct: 1 MNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPP 60
Query: 102 NIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGA 161
NIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGA
Sbjct: 61 NIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGA 120
Query: 162 LDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTG 221
LDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTG
Sbjct: 121 LDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTG 180
Query: 222 NKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENK 281
NKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENK
Sbjct: 181 NKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENK 240
Query: 282 NVXXXXXXXXXXXXXXXKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHE 341
NV KQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHE
Sbjct: 241 NVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHE 300
Query: 342 GPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKL 401
GPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKL
Sbjct: 301 GPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKL 360
Query: 402 RAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRP 461
RAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRP
Sbjct: 361 RAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRP 420
Query: 462 DLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGK 521
DLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGK
Sbjct: 421 DLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGK 480
Query: 522 FKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFS 580
FKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFS
Sbjct: 481 FKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFS 539
>gi|91077850|ref|XP_971897.1| PREDICTED: similar to Insulin-degrading enzyme (Insulysin)
(Insulinase) (Insulin protease) [Tribolium castaneum]
Length = 977
Score = 1075 bits (2779), Expect = 0.0, Method: Composition-based stats.
Identities = 516/970 (53%), Positives = 708/970 (72%), Gaps = 8/970 (0%)
Query: 44 NPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNI 103
N ++R+ N I KS EDKR YRGLELAN +KVLL+SDPTTDKS+AA+DV++G +SDP ++
Sbjct: 6 NLVLRRVEN-IIKSQEDKRLYRGLELANHMKVLLVSDPTTDKSAAAMDVNVGFMSDPRDV 64
Query: 104 AGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALD 163
GL+HFCEHMLFLGTKKYP EN+Y+++LSEH GSSNA T +HT YYFD+ + L ALD
Sbjct: 65 YGLAHFCEHMLFLGTKKYPNENDYNKYLSEHGGSSNAATYPDHTIYYFDIVPDELNNALD 124
Query: 164 RFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNK 223
RF+QFF+ PLF ES DRE+NAV+SEHEKN+ ND WR QL+K +PKHP+ FGTGN+
Sbjct: 125 RFSQFFIAPLFTESATDREMNAVNSEHEKNIPNDVWRKDQLDKHLADPKHPYHTFGTGNR 184
Query: 224 YTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNV 283
+TL+T P ++ I+VR ELLKFH +YSSN+M + VLG+ESLDDL +VVKLFSEV++K +
Sbjct: 185 HTLDTLPKEKNINVRDELLKFHDKWYSSNIMCLAVLGKESLDDLEQMVVKLFSEVKDKAI 244
Query: 284 XXXXXXXXXXXXXXXKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGP 343
+ PIKD+RNL + FP DLQ+YYKS+P HY+ HL+GHEGP
Sbjct: 245 AAPRWEEHPFKDEHFGTCVYMYPIKDVRNLNIVFPCRDLQEYYKSSPSHYISHLMGHEGP 304
Query: 344 GSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRA 403
GS+LS LK++GW N LV G + RG FF + VDLTEEG+ H++DI+ +FQY+ L+
Sbjct: 305 GSILSTLKARGWSNNLVAGSRPAPRGLGFFGVTVDLTEEGIKHIDDIVELIFQYLNMLKR 364
Query: 404 EGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDL 463
+GPQ+WV E +D+ + FRFKDKE PR Y + + L Y +E+VL+ YL E+RPD+
Sbjct: 365 QGPQKWVQDENRDIGNMLFRFKDKESPRSYIAGLVHTLQDYSMEDVLSCMYLFSEWRPDI 424
Query: 464 IEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFK 523
IE V + PE +R+ +++K +E + D+ E WYGT+YK IP++ +++W+ ++L+G FK
Sbjct: 425 IEQVWNDFVPEKIRIVVLAKQYENELDQVEPWYGTKYKVAKIPEKTLERWRKSELSGDFK 484
Query: 524 LPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFA 583
LP KNEFIPT+FE+ P++KE T +P +I+DTA++++WFKQD+ F LPKA + F+F SP A
Sbjct: 485 LPEKNEFIPTDFELYPIDKEVTEHPVIIQDTALTRVWFKQDETFLLPKANVMFDFVSPLA 544
Query: 584 YVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLK 643
Y+DPL+CN+ ++ ++L +D+LNEYAYAAELAGL ++L NT YG+ L++ GY++KQ I L
Sbjct: 545 YLDPLNCNLTHMLVQLFRDALNEYAYAAELAGLKWELINTKYGLILAIGGYSNKQHIFLD 604
Query: 644 KIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEA 703
K++EK+ F+ID KRFEI KE Y+R+L NF AEQP+QHA+YYL L+TE +WTK EL
Sbjct: 605 KVMEKLTNFKIDPKRFEICKENYIRNLKNFAAEQPYQHAVYYLAALLTEHSWTKQELLAT 664
Query: 704 LDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQL 763
+ +T+ +L+AFIPQ+LS++HIE L+HGN K+ AL ++Q+VED L+ + PLLP QL
Sbjct: 665 TEQLTIDKLEAFIPQILSKMHIECLIHGNANKEKALQLVQIVEDRLLSTLNMSPLLPRQL 724
Query: 764 VRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTL 823
+ RE++L D +VY+ +NEVH IE+YYQ +QS NM LELF QI+ EPCF+ L
Sbjct: 725 LLNRELKLEDGCNYVYEVQNEVHKESCIELYYQCGLQSKENNMKLELFAQIVQEPCFDIL 784
Query: 824 RTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQ 883
RTKEQLGYIVFSG RR+NG+QGLR I+QS+K P L+ R+E FL M +++M+EE F
Sbjct: 785 RTKEQLGYIVFSGIRRSNGVQGLRIIVQSDKHPVRLDERIEEFLKNMLSYLKNMSEEEFA 844
Query: 884 KHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEM 943
+H +ALA +RL+KPK+LS + +WGEI SQQY+FDR N EVAYL+TLTKEDII FYK +
Sbjct: 845 RHREALAAQRLEKPKQLSTQTNIFWGEITSQQYHFDRANVEVAYLRTLTKEDIIDFYKSL 904
Query: 944 LAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLP 1003
L +A R K+SVHV++ + + ++ + V+ ++T FK
Sbjct: 905 LEENAQFRKKLSVHVVSMADGGAGKMAASDKEYTVD-------SKGTVVCDITVFKSSHE 957
Query: 1004 LFPLVKPHIN 1013
+ PLV+P+IN
Sbjct: 958 MHPLVQPYIN 967