BLASTP 2.2.17 [Aug-26-2007]
Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Reference for composition-based statistics:
Schäffer, Alejandro A., L. Aravind, Thomas L. Madden,
Schaffer, Alejandro A., L. Aravind, Thomas L. Madden,
Sergei Shavirin, John L. Spouge, Yuri I. Wolf,
Eugene V. Koonin, and Stephen F. Altschul (2001),
"Improving the accuracy of PSI-BLAST protein database searches with
composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005.
Query= XP_822397.1__[Trypanosoma_brucei]
(234 letters)
Database: nr.pal
6,348,806 sequences; 2,166,943,470 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|71746684|ref|XP_822397.1| hypoxanthine-guanine phosphori... 471 e-131
gi|71649338|ref|XP_813397.1| hypoxanthine-guanine phosphori... 298 2e-79
gi|71656750|ref|XP_816917.1| hypoxanthine-guanine phosphori... 296 1e-78
gi|154337144|ref|XP_001564805.1| xanthine phosphoribosyltra... 263 6e-69
gi|157868948|ref|XP_001683026.1| xanthine phosphoribosyltra... 254 3e-66
gi|5759078|gb|AAD50967.1|AF170105_2 xanthine phosphoribosyl... 254 4e-66
gi|146080158|ref|XP_001463948.1| XRPT, xanthine phosphoribo... 233 6e-60
gi|71746686|ref|XP_822398.1| hypoxanthine-guanine phosphori... 161 3e-38
gi|71746700|ref|XP_822405.1| hypoxanthine-guanine phosphori... 159 1e-37
gi|26395149|sp|Q27541|HPRT_CRIFA Hypoxanthine-guanine phosp... 141 3e-32
gi|71656748|ref|XP_816916.1| hypoxanthine-guanine phosphori... 140 1e-31
gi|51247209|pdb|1PZM|A Chain A, Crystal Structure Of Hgprt-... 139 1e-31
gi|7245408|pdb|1TC2|A Chain A, Ternary Substrate Complex Of... 139 2e-31
gi|6435813|pdb|1TC1|A Chain A, A 1.4 Angstrom Crystal Struc... 139 2e-31
gi|146080155|ref|XP_001463947.1| HGPRT,hypoxanthine-guanine... 138 3e-31
gi|49258400|pdb|1P17|A Chain A, Hypoxanthine Phosphoribosyl... 138 4e-31
gi|21465605|pdb|1I14|A Chain A, Analysis Of An Invariant As... 137 6e-31
gi|71649336|ref|XP_813396.1| hypoxanthine-guanine phosphori... 137 6e-31
gi|21465601|pdb|1I0L|A Chain A, Analysis Of An Invariant As... 137 6e-31
gi|154337142|ref|XP_001564804.1| hypoxanthine-guanine phosp... 137 6e-31
gi|157868946|ref|XP_001683025.1| hypoxanthine-guanine phosp... 137 8e-31
gi|21465599|pdb|1I0I|A Chain A, Analysis Of An Invariant As... 136 9e-31
gi|21465603|pdb|1I13|A Chain A, Analysis Of An Invariant As... 136 1e-30
gi|116333184|ref|YP_794711.1| Hypoxanthine-guanine phosphor... 131 4e-29
gi|169193152|ref|ZP_02852841.1| hypoxanthine phosphoribosyl... 130 6e-29
gi|7381265|gb|AAF61462.1|AF139722_1 hypoxanthine-guanine ph... 127 6e-28
gi|28377430|ref|NP_784322.1| hypoxanthine-guanine phosphori... 127 8e-28
gi|134300215|ref|YP_001113711.1| hypoxanthine phosphoribosy... 125 3e-27
gi|158320387|ref|YP_001512894.1| hypoxanthine phosphoribosy... 124 3e-27
gi|91701622|gb|ABE47510.1| hypoxanthine-guanine phosphoribo... 124 5e-27
gi|150389408|ref|YP_001319457.1| hypoxanthine phosphoribosy... 124 6e-27
gi|91701618|gb|ABE47508.1| hypoxanthine-guanine phosphoribo... 123 1e-26
gi|91701620|gb|ABE47509.1| hypoxanthine-guanine phosphoribo... 123 1e-26
gi|125622901|ref|YP_001031384.1| hypoxanthine phosphoribosy... 123 1e-26
gi|116510860|ref|YP_808076.1| Hypoxanthine-guanine phosphor... 122 1e-26
gi|92088686|ref|ZP_01273646.1| Hypoxanthine phosphoribosyl ... 122 1e-26
gi|15672002|ref|NP_266176.1| hypoxantine-guanine phosphoryb... 122 2e-26
gi|148543504|ref|YP_001270874.1| hypoxanthine phosphoribosy... 121 3e-26
gi|158321041|ref|YP_001513548.1| hypoxanthine phosphoribosy... 120 6e-26
gi|51891638|ref|YP_074329.1| hypoxanthine-guanine phosphori... 120 8e-26
gi|81096412|ref|ZP_00874757.1| Hypoxanthine phosphoribosyl ... 119 1e-25
gi|121535065|ref|ZP_01666882.1| hypoxanthine phosphoribosyl... 118 3e-25
gi|91201682|emb|CAJ74742.1| similar to hypoxanthine-guanine... 118 3e-25
gi|147678887|ref|YP_001213102.1| hypoxanthine-guanine phosp... 118 3e-25
gi|146317676|ref|YP_001197388.1| Hypoxanthine-guanine phosp... 118 4e-25
gi|90962326|ref|YP_536242.1| Hypoxanthine-guanine phosphori... 117 4e-25
gi|159466726|ref|XP_001691549.1| hypothetical protein CHLRE... 117 5e-25
gi|125716900|ref|YP_001034033.1| Hypoxanthine guanine phosp... 116 1e-24
gi|160947240|ref|ZP_02094407.1| hypothetical protein PEPMIC... 116 1e-24
gi|116493274|ref|YP_805009.1| Hypoxanthine-guanine phosphor... 115 2e-24
gi|160943997|ref|ZP_02091227.1| hypothetical protein FAEPRA... 115 2e-24
gi|157690850|ref|YP_001485312.1| hypoxanthine phosphoribosy... 115 2e-24
gi|78187382|ref|YP_375425.1| Hypoxanthine phosphoribosyl tr... 115 2e-24
gi|118045742|ref|ZP_01514399.1| hypoxanthine phosphoribosyl... 115 3e-24
gi|116495972|ref|YP_807706.1| Hypoxanthine-guanine phosphor... 115 3e-24
gi|154499605|ref|ZP_02037643.1| hypothetical protein BACCAP... 114 4e-24
gi|167772097|ref|ZP_02444150.1| hypothetical protein ANACOL... 114 4e-24
gi|150390663|ref|YP_001320712.1| hypoxanthine phosphoribosy... 114 5e-24
gi|29374905|ref|NP_814058.1| hypoxanthine-guanine phosphori... 114 5e-24
gi|167465128|ref|ZP_02330217.1| hypothetical protein Plarl_... 114 5e-24
gi|118380011|ref|XP_001023170.1| hypoxanthine phosphoribosy... 113 1e-23
gi|85858559|ref|YP_460761.1| hypoxanthine-guanine phosphori... 113 1e-23
gi|73663555|ref|YP_302336.1| putative hypoxanthine-guanine ... 113 1e-23
gi|15899961|ref|NP_344565.1| hypoxanthine-guanine phosphori... 112 1e-23
gi|114771134|ref|ZP_01448574.1| hypoxanthine phosphoribosyl... 112 2e-23
gi|168705168|ref|ZP_02737445.1| hypoxanthine-guanine phosph... 112 2e-23
gi|169831788|ref|YP_001717770.1| hypoxanthine phosphoribosy... 112 2e-23
gi|116748861|ref|YP_845548.1| hypoxanthine phosphoribosyltr... 112 3e-23
gi|34762817|ref|ZP_00143803.1| Hypoxanthine-guanine phospho... 111 3e-23
gi|47085697|ref|NP_998151.1| hypoxanthine phosphoribosyltra... 111 3e-23
gi|145953742|ref|ZP_01802750.1| hypothetical protein CdifQ_... 111 3e-23
gi|37522359|ref|NP_925736.1| hypoxanthine phosphoribosyltra... 111 4e-23
gi|126700851|ref|YP_001089748.1| hypoxanthine phosphoribosy... 111 4e-23
gi|56961887|ref|YP_173609.1| hypoxanthine-guanine phosphori... 111 4e-23
gi|157149744|ref|YP_001451359.1| hypoxanthine phosphoribosy... 111 4e-23
gi|163791059|ref|ZP_02185480.1| hypoxanthine-guanine phosph... 111 5e-23
gi|148997946|ref|ZP_01825459.1| hypoxanthine phosphoribosyl... 110 5e-23
gi|148229801|ref|NP_001090235.1| phosphoribosyl transferase... 110 5e-23
gi|89211109|ref|ZP_01189486.1| Hypoxanthine phosphoribosyl ... 110 5e-23
gi|163942549|ref|YP_001647433.1| hypoxanthine phosphoribosy... 110 7e-23
gi|167006909|ref|ZP_02272383.1| Hypoxanthine-guanine phosph... 110 7e-23
gi|81429210|ref|YP_396211.1| Hypoxanthine phosphoribosyltra... 110 8e-23
gi|153893575|ref|ZP_02014261.1| Hypoxanthine phosphoribosyl... 110 1e-22
gi|459817|gb|AAB59392.1| hypoxanthine phosphoribosyltransfe... 110 1e-22
gi|109132354|ref|XP_001097691.1| PREDICTED: similar to Hypo... 109 1e-22
gi|22536200|ref|NP_687051.1| hypoxanthine-guanine phosphori... 109 1e-22
gi|45361471|ref|NP_989312.1| hypoxanthine phosphoribosyltra... 109 1e-22
gi|42784021|ref|NP_981268.1| hypoxanthine-guanine phosphori... 109 2e-22
gi|126342411|ref|XP_001375158.1| PREDICTED: similar to hypo... 109 2e-22
gi|164449238|gb|ABY56069.1| hypoxanthine phosphoribosyltran... 109 2e-22
gi|119632165|gb|EAX11760.1| hypoxanthine phosphoribosyltran... 109 2e-22
gi|152977166|ref|YP_001376683.1| hypoxanthine phosphoribosy... 108 2e-22
gi|166984605|ref|ZP_02255942.1| hypoxanthine-guanine phosph... 108 2e-22
gi|89272902|emb|CAJ82941.1| hypoxanthine phosphoribosyltran... 108 2e-22
gi|19703633|ref|NP_603195.1| Hypoxanthine-guanine phosphori... 108 2e-22
gi|45382333|ref|NP_990179.1| hypoxanthine phosphoribosyltra... 108 3e-22
gi|54695568|gb|AAV38156.1| hypoxanthine phosphoribosyltrans... 108 3e-22
gi|459815|gb|AAB59391.1| hypoxanthine phosphoribosyltransfe... 108 3e-22
gi|4504483|ref|NP_000185.1| hypoxanthine phosphoribosyltran... 108 3e-22
gi|309315|gb|AAA96232.1| hprt gene product 108 3e-22
>gi|71746684|ref|XP_822397.1| hypoxanthine-guanine phosphoribosyltransferase [Trypanosoma brucei]
gi|70832065|gb|EAN77569.1| hypoxanthine-guanine phosphoribosyltransferase, putative
[Trypanosoma brucei]
Length = 234
Score = 471 bits (1213), Expect = e-131, Method: Composition-based stats.
Identities = 234/234 (100%), Positives = 234/234 (100%)
Query: 1 MHSGHPLKPNFVGRDADGNVTVDGRSYPMAESVVATESTIHRSMKEMAQTLANAYKTLKH 60
MHSGHPLKPNFVGRDADGNVTVDGRSYPMAESVVATESTIHRSMKEMAQTLANAYKTLKH
Sbjct: 1 MHSGHPLKPNFVGRDADGNVTVDGRSYPMAESVVATESTIHRSMKEMAQTLANAYKTLKH 60
Query: 61 RDTHNKGNSALAPITDENPLIIISVLKGSYIFTADMVRYLGDCGLPNVVDFIRITSYRGT 120
RDTHNKGNSALAPITDENPLIIISVLKGSYIFTADMVRYLGDCGLPNVVDFIRITSYRGT
Sbjct: 61 RDTHNKGNSALAPITDENPLIIISVLKGSYIFTADMVRYLGDCGLPNVVDFIRITSYRGT 120
Query: 121 TKSSGTVQVLDNLRFTELTGKHVLIMEDIADTGRTMKLLVEKIRREYRPASLKVCVLVDK 180
TKSSGTVQVLDNLRFTELTGKHVLIMEDIADTGRTMKLLVEKIRREYRPASLKVCVLVDK
Sbjct: 121 TKSSGTVQVLDNLRFTELTGKHVLIMEDIADTGRTMKLLVEKIRREYRPASLKVCVLVDK 180
Query: 181 PGGRVVDFKPEFVCLTAPTRYVVGYGFEVNDRYRNYRHVFVLKPEYAKRYPSKL 234
PGGRVVDFKPEFVCLTAPTRYVVGYGFEVNDRYRNYRHVFVLKPEYAKRYPSKL
Sbjct: 181 PGGRVVDFKPEFVCLTAPTRYVVGYGFEVNDRYRNYRHVFVLKPEYAKRYPSKL 234
>gi|71649338|ref|XP_813397.1| hypoxanthine-guanine phosphoribosyltransferase, putative
[Trypanosoma cruzi strain CL Brener]
gi|70878275|gb|EAN91546.1| hypoxanthine-guanine phosphoribosyltransferase, putative
[Trypanosoma cruzi]
Length = 231
Score = 298 bits (762), Expect = 2e-79, Method: Composition-based stats.
Identities = 138/223 (61%), Positives = 183/223 (82%), Gaps = 3/223 (1%)
Query: 12 VGRDADGNVTVDGRSYPMAESVVATESTIHRSMKEMAQTLANAYKTLKHRDTHNKGNSAL 71
V R+A+G + VDG++YPMAE +VATES I RS+K +A+ +A+ Y+ L HRDTH G +
Sbjct: 12 VSRNAEGVIVVDGKAYPMAEELVATESVIQRSIKAVAKQIADFYRPLSHRDTH--GGGGV 69
Query: 72 APITDENPLIIISVLKGSYIFTADMVRYLGDCGLPNVVDFIRITSYRGTTKSSGTVQVLD 131
API+DENPLIIISVLKGSYIFTADMVRYLGD GLP+VVDF+R+ SYRGT+ S+ +Q+L
Sbjct: 70 APISDENPLIIISVLKGSYIFTADMVRYLGDYGLPHVVDFLRVASYRGTS-STNKMQLLA 128
Query: 132 NLRFTELTGKHVLIMEDIADTGRTMKLLVEKIRREYRPASLKVCVLVDKPGGRVVDFKPE 191
+F L GKHVLI+EDI D+G+T++ +++K++RE++PA+LKVCVL DKPGGR V +P+
Sbjct: 129 ETQFKALRGKHVLILEDIVDSGKTLRYILDKVQREHQPATLKVCVLADKPGGRRVTMQPD 188
Query: 192 FVCLTAPTRYVVGYGFEVNDRYRNYRHVFVLKPEYAKRYPSKL 234
FVCLT P +YV+GYGFEVNDR+R +RH+F L+P A+RYP+ L
Sbjct: 189 FVCLTVPNKYVIGYGFEVNDRFRCFRHIFTLRPGEARRYPAHL 231
>gi|71656750|ref|XP_816917.1| hypoxanthine-guanine phosphoribosyltransferase, putative
[Trypanosoma cruzi strain CL Brener]
gi|70882077|gb|EAN95066.1| hypoxanthine-guanine phosphoribosyltransferase, putative
[Trypanosoma cruzi]
Length = 231
Score = 296 bits (757), Expect = 1e-78, Method: Composition-based stats.
Identities = 137/223 (61%), Positives = 183/223 (82%), Gaps = 3/223 (1%)
Query: 12 VGRDADGNVTVDGRSYPMAESVVATESTIHRSMKEMAQTLANAYKTLKHRDTHNKGNSAL 71
V R+A+G + VDG++YPMAE +VATES I RS+K +A+ +A+ Y+ L HRDTH G +
Sbjct: 12 VSRNAEGVIVVDGKAYPMAEELVATESVIQRSIKAVAKQIADFYRPLSHRDTH--GGGGV 69
Query: 72 APITDENPLIIISVLKGSYIFTADMVRYLGDCGLPNVVDFIRITSYRGTTKSSGTVQVLD 131
API+DENPLIIISVLKGSYIFTADMVRYLGD GLP+VVDF+R+ SYRGT+ S+ +++L
Sbjct: 70 APISDENPLIIISVLKGSYIFTADMVRYLGDYGLPHVVDFLRVASYRGTS-STNKMKLLA 128
Query: 132 NLRFTELTGKHVLIMEDIADTGRTMKLLVEKIRREYRPASLKVCVLVDKPGGRVVDFKPE 191
+F L GKHVLI+EDI D+G+T++ +++K++RE++PA+LKVCVL DKPGGR V +P+
Sbjct: 129 ETQFKALRGKHVLILEDIVDSGKTLRYILDKVQREHQPATLKVCVLADKPGGRRVTMQPD 188
Query: 192 FVCLTAPTRYVVGYGFEVNDRYRNYRHVFVLKPEYAKRYPSKL 234
FVCLT P +YV+GYGFEVNDR+R +RH+F L+P A+RYP+ L
Sbjct: 189 FVCLTVPNKYVIGYGFEVNDRFRCFRHIFTLRPGEARRYPAHL 231
>gi|154337144|ref|XP_001564805.1| xanthine phosphoribosyltransferase [Leishmania braziliensis
MHOM/BR/75/M2904]
gi|134061843|emb|CAM38880.1| xanthine phosphoribosyltransferase [Leishmania braziliensis]
Length = 240
Score = 263 bits (672), Expect = 6e-69, Method: Composition-based stats.
Identities = 128/229 (55%), Positives = 164/229 (71%), Gaps = 9/229 (3%)
Query: 15 DADGNVTVDGRSYPMAESVVATESTIHRSMKEMAQTLANAYKTLKHRDTHNKGNSAL--- 71
DA G V VDGR YPMA S++ATE I +K MAQT+AN YK L HRD N A
Sbjct: 12 DAQGRVFVDGREYPMASSIIATEDVIQSKIKAMAQTIANDYKLLTHRDCRLPPNVATGME 71
Query: 72 -----APITDENPLIIISVLKGSYIFTADMVRYLGDCGLPNVVDFIRITSYRGTTKSSGT 126
API+ +NPLII+SVLKGSYIFTAD +RYLGDCGLP+VVDF+R+TSY T+S+G
Sbjct: 72 TVVSEAPISYDNPLIIVSVLKGSYIFTADFIRYLGDCGLPHVVDFVRLTSYNDGTRSTGR 131
Query: 127 VQVLDNLRFTELTGKHVLIMEDIADTGRTMKLLVEKIRREYRPASLKVCVLVDK-PGGRV 185
V +L L+F L GKHVLI+ED+ D+GRT+ L I +Y+P S+K V+V+K R
Sbjct: 132 VAMLSGLKFENLRGKHVLIVEDVCDSGRTLHFLRTSIIEKYQPKSIKTLVMVNKEAAARK 191
Query: 186 VDFKPEFVCLTAPTRYVVGYGFEVNDRYRNYRHVFVLKPEYAKRYPSKL 234
VDF+PE+ CL++P +Y++GYGFEVNDRYR+ RH+ +L+ A RYP+KL
Sbjct: 192 VDFEPEYACLSSPNKYIIGYGFEVNDRYRDLRHILILRDGEATRYPAKL 240
>gi|157868948|ref|XP_001683026.1| xanthine phosphoribosyltransferase [Leishmania major]
gi|68223909|emb|CAJ04332.1| xanthine phosphoribosyltransferase [Leishmania major]
Length = 238
Score = 254 bits (649), Expect = 3e-66, Method: Composition-based stats.
Identities = 124/227 (54%), Positives = 161/227 (70%), Gaps = 7/227 (3%)
Query: 15 DADGNVTVDGRSYPMAESVVATESTIHRSMKEMAQTLANAYKTLKHRDTH------NKGN 68
DA G V VDGR YPMA +VATE I ++K MA T+A YK+L HRD
Sbjct: 12 DAQGRVFVDGREYPMASGIVATEDVIQANIKAMANTIAKDYKSLSHRDVRLSPGTAATAE 71
Query: 69 SALAPITDENPLIIISVLKGSYIFTADMVRYLGDCGLPNVVDFIRITSYRGTTKSSGTVQ 128
+A API+ +NPLIIISVLKGSYIFT+D +RYLGDCGLP+VVDF+R+ SY T S+G +
Sbjct: 72 AAEAPISYDNPLIIISVLKGSYIFTSDFIRYLGDCGLPHVVDFVRLASYNSDTTSTGQIS 131
Query: 129 VLDNLRFTELTGKHVLIMEDIADTGRTMKLLVEKIRREYRPASLKVCVLVDKP-GGRVVD 187
+L LRF L GKHVLI+ED+ D+GRT++ L + I +++P S+K V+V+K R +D
Sbjct: 132 MLAGLRFENLRGKHVLIVEDVCDSGRTLRFLRDYIMEKFQPKSVKTLVMVNKEQAARKLD 191
Query: 188 FKPEFVCLTAPTRYVVGYGFEVNDRYRNYRHVFVLKPEYAKRYPSKL 234
F PE+ CL P +Y+VGYGFEVNDRYR+ RH+F+L+ A RYP+KL
Sbjct: 192 FDPEYFCLAGPNKYIVGYGFEVNDRYRDLRHIFILRDGEATRYPAKL 238
>gi|5759078|gb|AAD50967.1|AF170105_2 xanthine phosphoribosyltransferase XPRT [Leishmania donovani]
Length = 241
Score = 254 bits (648), Expect = 4e-66, Method: Composition-based stats.
Identities = 125/230 (54%), Positives = 161/230 (70%), Gaps = 10/230 (4%)
Query: 15 DADGNVTVDGRSYPMAESVVATESTIHRSMKEMAQTLANAYKTLKHRDTH---------N 65
DA G V VDGR YPMA +VATE I ++K MA T+A YK+L HRD
Sbjct: 12 DAQGRVFVDGREYPMASGIVATEDVIQTNIKAMAHTIAKDYKSLSHRDARLSPSTAETAE 71
Query: 66 KGNSALAPITDENPLIIISVLKGSYIFTADMVRYLGDCGLPNVVDFIRITSYRGTTKSSG 125
+A API+ +NPLIIISVLKGSYIFT+D +RYLGDCGLP+VVDF+R+ SY TKS+G
Sbjct: 72 AAEAAEAPISYDNPLIIISVLKGSYIFTSDFIRYLGDCGLPHVVDFVRLASYNSGTKSTG 131
Query: 126 TVQVLDNLRFTELTGKHVLIMEDIADTGRTMKLLVEKIRREYRPASLKVCVLVDKP-GGR 184
+ +L LRF L GKHVLI+ED+ D+GRT++ L + I +++P S+K V+V+K R
Sbjct: 132 QISMLAGLRFENLRGKHVLIVEDVCDSGRTLRFLRDYIMEKFQPKSIKTLVMVNKEQAAR 191
Query: 185 VVDFKPEFVCLTAPTRYVVGYGFEVNDRYRNYRHVFVLKPEYAKRYPSKL 234
VDF PE+ CL P +Y+VGYGFEVNDRYR+ RH+ +L+ A RYP+KL
Sbjct: 192 KVDFDPEYFCLAGPNKYIVGYGFEVNDRYRDLRHILILRDGEATRYPAKL 241
>gi|146080158|ref|XP_001463948.1| XRPT, xanthine phosphoribosyltransferase [Leishmania infantum
JPCM5]
gi|134068037|emb|CAM66322.1| XRPT, xanthine phosphoribosyltransferase [Leishmania infantum]
Length = 216
Score = 233 bits (595), Expect = 6e-60, Method: Composition-based stats.
Identities = 115/216 (53%), Positives = 151/216 (69%), Gaps = 10/216 (4%)
Query: 29 MAESVVATESTIHRSMKEMAQTLANAYKTLKHRDTH---------NKGNSALAPITDENP 79
MA +VATE I ++K MA T+A YK+L HRD +A API+ +NP
Sbjct: 1 MASGIVATEDVIQTNIKAMAHTIAKDYKSLSHRDARLSPSTAETAEAAEAAEAPISYDNP 60
Query: 80 LIIISVLKGSYIFTADMVRYLGDCGLPNVVDFIRITSYRGTTKSSGTVQVLDNLRFTELT 139
LIIISVLKGSYIFT+D +RYLGDCGLP+VVDF+R+ SY TKS+G + +L LRF L
Sbjct: 61 LIIISVLKGSYIFTSDFIRYLGDCGLPHVVDFVRLASYNSGTKSTGQISMLAGLRFENLR 120
Query: 140 GKHVLIMEDIADTGRTMKLLVEKIRREYRPASLKVCVLVDKP-GGRVVDFKPEFVCLTAP 198
GKHVLI+ED+ D+GRT++ L + I +++P S+K V+V+K R VDF PE+ CL P
Sbjct: 121 GKHVLIVEDVCDSGRTLRFLRDYIMEKFQPKSIKTLVMVNKEQAARKVDFDPEYFCLAGP 180
Query: 199 TRYVVGYGFEVNDRYRNYRHVFVLKPEYAKRYPSKL 234
+Y+VGYGFEVNDRYR+ RH+ +L+ A RYP+KL
Sbjct: 181 NKYIVGYGFEVNDRYRDLRHILILRDGEATRYPAKL 216
>gi|71746686|ref|XP_822398.1| hypoxanthine-guanine phosphoribosyltransferase [Trypanosoma brucei]
gi|547672|sp|Q07010|HPRT_TRYBB Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) (HGPRTase)
gi|162105|gb|AAA16328.1| hypoxanthine-guanine phosphoribosyltransferase
gi|70832066|gb|EAN77570.1| hypoxanthine-guanine phosphoribosyltransferase [Trypanosoma brucei]
Length = 210
Score = 161 bits (408), Expect = 3e-38, Method: Composition-based stats.
Identities = 91/209 (43%), Positives = 129/209 (61%), Gaps = 17/209 (8%)
Query: 27 YPMAESVVATESTIHRSMKEMAQTLANAYKTLKHRDTHNKGNSALAPITDENPLIIISVL 86
Y A SV+ TE+ +H M+ +AQ +A+ Y N L P+ ENPL+I+SVL
Sbjct: 7 YDFATSVLFTEAELHTRMRGVAQRIADDYS-----------NCNLKPL--ENPLVIVSVL 53
Query: 87 KGSYIFTADMVRYLGDCGLPNVVDFIRITSYRGTTKSSGTVQV-LDNLRFTELTGKHVLI 145
KGS++FTADMVR LGD G+P V+F+R +SY TKS G V V D L ++ GKHVL+
Sbjct: 54 KGSFVFTADMVRILGDFGVPTRVEFLRASSYGHDTKSCGRVDVKADGL--CDIRGKHVLV 111
Query: 146 MEDIADTGRTMKLLVEKIRREYRPASLKVCVLVDKPGGRVVDFKPEFVCLTAPTRYVVGY 205
+EDI DT T++ +V+ +++ PAS+K V +DKPGGR + F E+V P +VVGY
Sbjct: 112 LEDILDTALTLREVVDSLKKS-EPASIKTLVAIDKPGGRKIPFTAEYVVADVPNVFVVGY 170
Query: 206 GFEVNDRYRNYRHVFVLKPEYAKRYPSKL 234
G + + YR R V +LKP + + +L
Sbjct: 171 GLDYDQSYREVRDVVILKPSVYETWGKEL 199
>gi|71746700|ref|XP_822405.1| hypoxanthine-guanine phosphoribosyltransferase [Trypanosoma brucei]
gi|70832073|gb|EAN77577.1| hypoxanthine-guanine phosphoribosyltransferase [Trypanosoma brucei]
Length = 210
Score = 159 bits (403), Expect = 1e-37, Method: Composition-based stats.
Identities = 89/209 (42%), Positives = 129/209 (61%), Gaps = 17/209 (8%)
Query: 27 YPMAESVVATESTIHRSMKEMAQTLANAYKTLKHRDTHNKGNSALAPITDENPLIIISVL 86
Y A SV+ TE+ +H M+ +AQ +A+ Y N L P+ ENPL+++SVL
Sbjct: 7 YDFATSVLFTEAELHTRMRGVAQRIADDYS-----------NCNLKPL--ENPLVVVSVL 53
Query: 87 KGSYIFTADMVRYLGDCGLPNVVDFIRITSYRGTTKSSGTVQV-LDNLRFTELTGKHVLI 145
+GS++FTADMVR LGD G+P V+F+R +SY TKS G V V D L ++ GKHVL+
Sbjct: 54 RGSFVFTADMVRILGDFGVPTRVEFLRASSYGHDTKSCGRVDVKADGL--CDIRGKHVLV 111
Query: 146 MEDIADTGRTMKLLVEKIRREYRPASLKVCVLVDKPGGRVVDFKPEFVCLTAPTRYVVGY 205
+EDI DT T++ +V+ +++ PAS+K V +DKPGGR + F E+V P +VVGY
Sbjct: 112 LEDILDTALTLREVVDSLKKS-EPASIKTLVAIDKPGGRKIPFTAEYVVADVPNVFVVGY 170
Query: 206 GFEVNDRYRNYRHVFVLKPEYAKRYPSKL 234
G + + YR R V +LKP + + +L
Sbjct: 171 GLDYDQSYREVRDVVILKPSVYETWGKEL 199
>gi|26395149|sp|Q27541|HPRT_CRIFA Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) (HGPRTase)
gi|643084|gb|AAB04164.1| hypoxanthine-guanine phophoribosyltransferase
Length = 208
Score = 141 bits (356), Expect = 3e-32, Method: Composition-based stats.
Identities = 80/210 (38%), Positives = 125/210 (59%), Gaps = 16/210 (7%)
Query: 25 RSYPMAESVVATESTIHRSMKEMAQTLANAYKTLKHRDTHNKGNSALAPITDENPLIIIS 84
R YPM+ +AT+ I + + A+ +A YK ++DENPL ++
Sbjct: 15 RHYPMSCRTLATQEQIWSATAKCAKQIAEDYKQYN--------------LSDENPLYLLC 60
Query: 85 VLKGSYIFTADMVRYLGDCGLPNVVDFIRITSYRGTTKSSGTVQVLDNLRFTELTGKHVL 144
VLKGS++FTAD+ R+L D G+P ++FI +SY K+SG V++L ++R + +H+L
Sbjct: 61 VLKGSFMFTADLARFLCDEGVPVRIEFICASSYGTDVKTSGEVRLLLDVR-DPVENRHLL 119
Query: 145 IMEDIADTGRTMKLLVEKIRREYRPASLKVCVLVDKPGGRVVDFKPEFVCLTAPTRYVVG 204
I+EDI D+ T++ L ++ + +PASLK VL+DKP GR V ++ +T P +V+G
Sbjct: 120 IVEDIVDSAITLEYL-KRFLQAKQPASLKTVVLLDKPSGRKVTLSVDYPVITIPHAFVIG 178
Query: 205 YGFEVNDRYRNYRHVFVLKPEYAKRYPSKL 234
YG + + YR R V VLK EY ++ SKL
Sbjct: 179 YGMDFAEAYRELRDVCVLKKEYYEKPASKL 208
>gi|71656748|ref|XP_816916.1| hypoxanthine-guanine phosphoribosyltransferase, putative
[Trypanosoma cruzi strain CL Brener]
gi|70882076|gb|EAN95065.1| hypoxanthine-guanine phosphoribosyltransferase, putative
[Trypanosoma cruzi]
Length = 241
Score = 140 bits (352), Expect = 1e-31, Method: Composition-based stats.
Identities = 86/210 (40%), Positives = 123/210 (58%), Gaps = 16/210 (7%)
Query: 25 RSYPMAESVVATESTIHRSMKEMAQTLANAYKTLKHRDTHNKGNSALAPITDENPLIIIS 84
R Y AE ++ TE I +KE+A+ +A+ YK L P NPL++IS
Sbjct: 23 REYEFAEKILFTEEEIRTRIKEVAKRIADDYK-----------GKGLRPYV--NPLVLIS 69
Query: 85 VLKGSYIFTADMVRYLGDCGLPNVVDFIRITSYRGTTKSSGTVQVLDNLRFTELTGKHVL 144
VLKGS++FTAD+ R L D +P ++FI ++SY SSG V++L + R + + G HVL
Sbjct: 70 VLKGSFMFTADLCRALCDFNVPVRMEFICVSSYGEGLTSSGQVRMLLDTRHS-IEGHHVL 128
Query: 145 IMEDIADTGRTMKLLVEKIRREYRPASLKVCVLVDKPGGRVVDFKPEFVCLTAPTRYVVG 204
I+EDI DT T+ L + RPASLK VL+DK GR V F ++V P +V+G
Sbjct: 129 IVEDIVDTALTLNYLYH-MYFTRRPASLKTVVLLDKREGRRVPFSADYVVANIPNAFVIG 187
Query: 205 YGFEVNDRYRNYRHVFVLKPE-YAKRYPSK 233
YG + +D YR R + VL+PE YA+R ++
Sbjct: 188 YGLDYDDTYRELRDIVVLRPEVYAEREAAR 217
>gi|51247209|pdb|1PZM|A Chain A, Crystal Structure Of Hgprt-Ase From Leishmania Tarentolae
In Complex With Gmp
gi|51247210|pdb|1PZM|B Chain B, Crystal Structure Of Hgprt-Ase From Leishmania Tarentolae
In Complex With Gmp
Length = 211
Score = 139 bits (351), Expect = 1e-31, Method: Composition-based stats.
Identities = 82/225 (36%), Positives = 131/225 (58%), Gaps = 16/225 (7%)
Query: 10 NFVGRDADGNVTVDGRSYPMAESVVATESTIHRSMKEMAQTLANAYKTLKHRDTHNKGNS 69
N V +D V R+YPM+ + T+ + + + A+ +A YK D H
Sbjct: 3 NSVKSPSDHVGDVGRRNYPMSARTLVTQEQVWAATAKCAKKIAADYK-----DFH----- 52
Query: 70 ALAPITDENPLIIISVLKGSYIFTADMVRYLGDCGLPNVVDFIRITSYRGTTKSSGTVQV 129
+T +NPL ++ VLKGS+IFTAD+ R+L D G+P V+FI +SY ++SG V++
Sbjct: 53 ----LTADNPLYLLCVLKGSFIFTADLARFLADEGVPVKVEFICASSYGSGVETSGQVRM 108
Query: 130 LDNLRFTELTGKHVLIMEDIADTGRTMKLLVEKIRREYRPASLKVCVLVDKPGGRVVDFK 189
L ++R + +H++++EDI D+ T++ L+ + +PASLK VL+DKP GR VD
Sbjct: 109 LLDVR-DSVENRHIMLVEDIVDSAITLQYLM-RFMLAKKPASLKTVVLLDKPSGRKVDVL 166
Query: 190 PEFVCLTAPTRYVVGYGFEVNDRYRNYRHVFVLKPEYAKRYPSKL 234
++ +T P +V+GYG + + YR R + VLK EY ++ SKL
Sbjct: 167 VDYPVITIPRAFVIGYGMDFAESYRELRDICVLKKEYYEKAESKL 211
>gi|7245408|pdb|1TC2|A Chain A, Ternary Substrate Complex Of The Hypoxanthine
Phosphoribosyltransferase From Trypanosoma Cruzi
gi|7245409|pdb|1TC2|B Chain B, Ternary Substrate Complex Of The Hypoxanthine
Phosphoribosyltransferase From Trypanosoma Cruzi
gi|49258406|pdb|1P19|A Chain A, Hypoxanthine Phosphoribosyltransferase From Trypanosoma
Cruzi, In Complex With The Product Imp
gi|49258407|pdb|1P19|B Chain B, Hypoxanthine Phosphoribosyltransferase From Trypanosoma
Cruzi, In Complex With The Product Imp
gi|49258408|pdb|1P19|C Chain C, Hypoxanthine Phosphoribosyltransferase From Trypanosoma
Cruzi, In Complex With The Product Imp
gi|49258409|pdb|1P19|D Chain D, Hypoxanthine Phosphoribosyltransferase From Trypanosoma
Cruzi, In Complex With The Product Imp
Length = 221
Score = 139 bits (350), Expect = 2e-31, Method: Composition-based stats.
Identities = 86/210 (40%), Positives = 123/210 (58%), Gaps = 16/210 (7%)
Query: 25 RSYPMAESVVATESTIHRSMKEMAQTLANAYKTLKHRDTHNKGNSALAPITDENPLIIIS 84
R Y AE ++ TE I +KE+A+ +A+ YK L P NPL++IS
Sbjct: 3 REYEFAEKILFTEEEIRTRIKEVAKRIADDYK-----------GKGLRPYV--NPLVLIS 49
Query: 85 VLKGSYIFTADMVRYLGDCGLPNVVDFIRITSYRGTTKSSGTVQVLDNLRFTELTGKHVL 144
VLKGS++FTAD+ R L D +P ++FI ++SY SSG V++L + R + + G HVL
Sbjct: 50 VLKGSFMFTADLCRALCDFNVPVRMEFICVSSYGEGLTSSGQVRMLLDTRHS-IEGHHVL 108
Query: 145 IMEDIADTGRTMKLLVEKIRREYRPASLKVCVLVDKPGGRVVDFKPEFVCLTAPTRYVVG 204
I+EDI DT T+ L + RPASLK VL+DK GR V F ++V P +V+G
Sbjct: 109 IVEDIVDTALTLNYLYH-MYFTRRPASLKTVVLLDKREGRRVPFSADYVVANIPNAFVIG 167
Query: 205 YGFEVNDRYRNYRHVFVLKPE-YAKRYPSK 233
YG + +D YR R + VL+PE YA+R ++
Sbjct: 168 YGLDYDDTYRELRDIVVLRPEVYAEREAAR 197
>gi|6435813|pdb|1TC1|A Chain A, A 1.4 Angstrom Crystal Structure For The Hypoxanthine
Phosphoribosyltransferase Of Trypanosoma Cruzi
gi|6435814|pdb|1TC1|B Chain B, A 1.4 Angstrom Crystal Structure For The Hypoxanthine
Phosphoribosyltransferase Of Trypanosoma Cruzi
Length = 220
Score = 139 bits (349), Expect = 2e-31, Method: Composition-based stats.
Identities = 86/210 (40%), Positives = 123/210 (58%), Gaps = 16/210 (7%)
Query: 25 RSYPMAESVVATESTIHRSMKEMAQTLANAYKTLKHRDTHNKGNSALAPITDENPLIIIS 84
R Y AE ++ TE I +KE+A+ +A+ YK L P NPL++IS
Sbjct: 2 REYEFAEKILFTEEEIRTRIKEVAKRIADDYK-----------GKGLRPYV--NPLVLIS 48
Query: 85 VLKGSYIFTADMVRYLGDCGLPNVVDFIRITSYRGTTKSSGTVQVLDNLRFTELTGKHVL 144
VLKGS++FTAD+ R L D +P ++FI ++SY SSG V++L + R + + G HVL
Sbjct: 49 VLKGSFMFTADLCRALCDFNVPVRMEFICVSSYGEGLTSSGQVRMLLDTRHS-IEGHHVL 107
Query: 145 IMEDIADTGRTMKLLVEKIRREYRPASLKVCVLVDKPGGRVVDFKPEFVCLTAPTRYVVG 204
I+EDI DT T+ L + RPASLK VL+DK GR V F ++V P +V+G
Sbjct: 108 IVEDIVDTALTLNYLYH-MYFTRRPASLKTVVLLDKREGRRVPFSADYVVANIPNAFVIG 166
Query: 205 YGFEVNDRYRNYRHVFVLKPE-YAKRYPSK 233
YG + +D YR R + VL+PE YA+R ++
Sbjct: 167 YGLDYDDTYRELRDIVVLRPEVYAEREAAR 196
>gi|146080155|ref|XP_001463947.1| HGPRT,hypoxanthine-guanine phosphoribosynthesis protein [Leishmania
infantum JPCM5]
gi|1170359|sp|P43152|HPRT_LEIDO Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) (HGPRTase)
gi|5759077|gb|AAD50966.1|AF170105_1 hypoxanthine-guanine phosphoribosyltransferase HGPRT [Leishmania
donovani]
gi|409144|gb|AAB00074.1| hypoxanthine-guanine phosphoribosyltransferase
gi|134068036|emb|CAM66321.1| HGPRT,hypoxanthine-guanine phosphoribosynthesis protein [Leishmania
infantum]
Length = 211
Score = 138 bits (347), Expect = 3e-31, Method: Composition-based stats.
Identities = 76/210 (36%), Positives = 126/210 (60%), Gaps = 16/210 (7%)
Query: 25 RSYPMAESVVATESTIHRSMKEMAQTLANAYKTLKHRDTHNKGNSALAPITDENPLIIIS 84
R+YPM+ + T+ + + + A+ +A Y++ K +T +NPL ++
Sbjct: 18 RNYPMSAHTLVTQEQVWAATAKCAKKIAEDYRSFK--------------LTTDNPLYLLC 63
Query: 85 VLKGSYIFTADMVRYLGDCGLPNVVDFIRITSYRGTTKSSGTVQVLDNLRFTELTGKHVL 144
VLKGS+IFTAD+ R+L D G+P V+FI +SY ++SG V++L ++R + +H+L
Sbjct: 64 VLKGSFIFTADLARFLADEGVPVKVEFICASSYGTGVETSGQVRMLLDVR-DSVENRHIL 122
Query: 145 IMEDIADTGRTMKLLVEKIRREYRPASLKVCVLVDKPGGRVVDFKPEFVCLTAPTRYVVG 204
I+EDI D+ T++ L+ + +PASLK VL+DKP GR V+ ++ +T P +V+G
Sbjct: 123 IVEDIVDSAITLQYLM-RFMLAKKPASLKTVVLLDKPSGRKVEVLVDYPVITIPHAFVIG 181
Query: 205 YGFEVNDRYRNYRHVFVLKPEYAKRYPSKL 234
YG + + YR R + VLK EY ++ SK+
Sbjct: 182 YGMDYAESYRELRDICVLKKEYYEKPESKV 211
>gi|49258400|pdb|1P17|A Chain A, Hypoxanthine Phosphoribosyltransferase From Trypanosoma
Cruzi, K68r Mutant, Complexed With The Product Imp
gi|49258401|pdb|1P17|B Chain B, Hypoxanthine Phosphoribosyltransferase From Trypanosoma
Cruzi, K68r Mutant, Complexed With The Product Imp
gi|49258402|pdb|1P17|C Chain C, Hypoxanthine Phosphoribosyltransferase From Trypanosoma
Cruzi, K68r Mutant, Complexed With The Product Imp
gi|49258403|pdb|1P17|D Chain D, Hypoxanthine Phosphoribosyltransferase From Trypanosoma
Cruzi, K68r Mutant, Complexed With The Product Imp
gi|49258404|pdb|1P18|A Chain A, Hypoxanthine Phosphoribosyltransferase From Trypanosoma
Cruzi, K68r Mutant, Ternary Substrates Complex
gi|49258405|pdb|1P18|B Chain B, Hypoxanthine Phosphoribosyltransferase From Trypanosoma
Cruzi, K68r Mutant, Ternary Substrates Complex
Length = 221
Score = 138 bits (347), Expect = 4e-31, Method: Composition-based stats.
Identities = 85/210 (40%), Positives = 123/210 (58%), Gaps = 16/210 (7%)
Query: 25 RSYPMAESVVATESTIHRSMKEMAQTLANAYKTLKHRDTHNKGNSALAPITDENPLIIIS 84
R Y AE ++ TE I +KE+A+ +A+ YK L P NPL++IS
Sbjct: 3 REYEFAEKILFTEEEIRTRIKEVAKRIADDYK-----------GKGLRPYV--NPLVLIS 49
Query: 85 VLKGSYIFTADMVRYLGDCGLPNVVDFIRITSYRGTTKSSGTVQVLDNLRFTELTGKHVL 144
VL+GS++FTAD+ R L D +P ++FI ++SY SSG V++L + R + + G HVL
Sbjct: 50 VLRGSFMFTADLCRALCDFNVPVRMEFICVSSYGEGLTSSGQVRMLLDTRHS-IEGHHVL 108
Query: 145 IMEDIADTGRTMKLLVEKIRREYRPASLKVCVLVDKPGGRVVDFKPEFVCLTAPTRYVVG 204
I+EDI DT T+ L + RPASLK VL+DK GR V F ++V P +V+G
Sbjct: 109 IVEDIVDTALTLNYLYH-MYFTRRPASLKTVVLLDKREGRRVPFSADYVVANIPNAFVIG 167
Query: 205 YGFEVNDRYRNYRHVFVLKPE-YAKRYPSK 233
YG + +D YR R + VL+PE YA+R ++
Sbjct: 168 YGLDYDDTYRELRDIVVLRPEVYAEREAAR 197
>gi|21465605|pdb|1I14|A Chain A, Analysis Of An Invariant Aspartic Acid In Hprts-Glutamic
Acid Mutant
gi|21465606|pdb|1I14|B Chain B, Analysis Of An Invariant Aspartic Acid In Hprts-Glutamic
Acid Mutant
Length = 221
Score = 137 bits (345), Expect = 6e-31, Method: Composition-based stats.
Identities = 85/210 (40%), Positives = 123/210 (58%), Gaps = 16/210 (7%)
Query: 25 RSYPMAESVVATESTIHRSMKEMAQTLANAYKTLKHRDTHNKGNSALAPITDENPLIIIS 84
R Y AE ++ TE I +KE+A+ +A+ YK L P NPL++IS
Sbjct: 3 REYEFAEKILFTEEEIRTRIKEVAKRIADDYK-----------GKGLRPYV--NPLVLIS 49
Query: 85 VLKGSYIFTADMVRYLGDCGLPNVVDFIRITSYRGTTKSSGTVQVLDNLRFTELTGKHVL 144
VLKGS++FTAD+ R L D +P ++FI ++SY SSG V++L + R + + G HVL
Sbjct: 50 VLKGSFMFTADLCRALCDFNVPVRMEFICVSSYGEGLTSSGQVRMLLDTRHS-IEGHHVL 108
Query: 145 IMEDIADTGRTMKLLVEKIRREYRPASLKVCVLVDKPGGRVVDFKPEFVCLTAPTRYVVG 204
I+EDI +T T+ L + RPASLK VL+DK GR V F ++V P +V+G
Sbjct: 109 IVEDIVETALTLNYLYH-MYFTRRPASLKTVVLLDKREGRRVPFSADYVVANIPNAFVIG 167
Query: 205 YGFEVNDRYRNYRHVFVLKPE-YAKRYPSK 233
YG + +D YR R + VL+PE YA+R ++
Sbjct: 168 YGLDYDDTYRELRDIVVLRPEVYAEREAAR 197
>gi|71649336|ref|XP_813396.1| hypoxanthine-guanine phosphoribosyltransferase, putative
[Trypanosoma cruzi strain CL Brener]
gi|386724|gb|AAB46391.1| hypoxanthine-guanine phosphoribosyltransferase
gi|70878274|gb|EAN91545.1| hypoxanthine-guanine phosphoribosyltransferase, putative
[Trypanosoma cruzi]
Length = 221
Score = 137 bits (345), Expect = 6e-31, Method: Composition-based stats.
Identities = 85/210 (40%), Positives = 122/210 (58%), Gaps = 16/210 (7%)
Query: 25 RSYPMAESVVATESTIHRSMKEMAQTLANAYKTLKHRDTHNKGNSALAPITDENPLIIIS 84
R Y AE ++ TE I + E+A+ +A+ YK L P NPL++IS
Sbjct: 3 REYEFAEKILFTEEEIRTRIMEVAKRIADDYK-----------GKGLRPYV--NPLVLIS 49
Query: 85 VLKGSYIFTADMVRYLGDCGLPNVVDFIRITSYRGTTKSSGTVQVLDNLRFTELTGKHVL 144
VLKGS++FTAD+ R L D +P ++FI ++SY SSG V++L + R + + G HVL
Sbjct: 50 VLKGSFMFTADLCRALSDFNVPVRMEFICVSSYGEGVTSSGQVRMLLDTRHS-IEGHHVL 108
Query: 145 IMEDIADTGRTMKLLVEKIRREYRPASLKVCVLVDKPGGRVVDFKPEFVCLTAPTRYVVG 204
I+EDI DT T+ L + RPASLK VL+DK GR V F ++V P +V+G
Sbjct: 109 IVEDIVDTALTLNYLYH-MYFTRRPASLKTVVLLDKREGRRVPFSADYVVANIPNAFVIG 167
Query: 205 YGFEVNDRYRNYRHVFVLKPE-YAKRYPSK 233
YG + +D YR R + VL+PE YA+R ++
Sbjct: 168 YGLDYDDTYRELRDIVVLRPEVYAEREAAR 197
>gi|21465601|pdb|1I0L|A Chain A, Analysis Of An Invariant Aspartic Acid In Hprts-Asparagine
Mutant
gi|21465602|pdb|1I0L|B Chain B, Analysis Of An Invariant Aspartic Acid In Hprts-Asparagine
Mutant
Length = 221
Score = 137 bits (345), Expect = 6e-31, Method: Composition-based stats.
Identities = 85/210 (40%), Positives = 123/210 (58%), Gaps = 16/210 (7%)
Query: 25 RSYPMAESVVATESTIHRSMKEMAQTLANAYKTLKHRDTHNKGNSALAPITDENPLIIIS 84
R Y AE ++ TE I +KE+A+ +A+ YK L P NPL++IS
Sbjct: 3 REYEFAEKILFTEEEIRTRIKEVAKRIADDYK-----------GKGLRPYV--NPLVLIS 49
Query: 85 VLKGSYIFTADMVRYLGDCGLPNVVDFIRITSYRGTTKSSGTVQVLDNLRFTELTGKHVL 144
VLKGS++FTAD+ R L D +P ++FI ++SY SSG V++L + R + + G HVL
Sbjct: 50 VLKGSFMFTADLCRALCDFNVPVRMEFICVSSYGEGLTSSGQVRMLLDTRHS-IEGHHVL 108
Query: 145 IMEDIADTGRTMKLLVEKIRREYRPASLKVCVLVDKPGGRVVDFKPEFVCLTAPTRYVVG 204
I+EDI +T T+ L + RPASLK VL+DK GR V F ++V P +V+G
Sbjct: 109 IVEDIVNTALTLNYLYH-MYFTRRPASLKTVVLLDKREGRRVPFSADYVVANIPNAFVIG 167
Query: 205 YGFEVNDRYRNYRHVFVLKPE-YAKRYPSK 233
YG + +D YR R + VL+PE YA+R ++
Sbjct: 168 YGLDYDDTYRELRDIVVLRPEVYAEREAAR 197
>gi|154337142|ref|XP_001564804.1| hypoxanthine-guanine phosphoribosyltransferase [Leishmania
braziliensis MHOM/BR/75/M2904]
gi|134061842|emb|CAM38879.1| hypoxanthine-guanine phosphoribosyltransferase [Leishmania
braziliensis]
Length = 211
Score = 137 bits (345), Expect = 6e-31, Method: Composition-based stats.
Identities = 82/210 (39%), Positives = 122/210 (58%), Gaps = 16/210 (7%)
Query: 25 RSYPMAESVVATESTIHRSMKEMAQTLANAYKTLKHRDTHNKGNSALAPITDENPLIIIS 84
RSYPM+ V T+ + + + A+T+A Y+ K LAP ENPL ++
Sbjct: 18 RSYPMSARTVITQEQVWAATAQCAKTIAQDYEKFK-----------LAP---ENPLYLLC 63
Query: 85 VLKGSYIFTADMVRYLGDCGLPNVVDFIRITSYRGTTKSSGTVQVLDNLRFTELTGKHVL 144
VLKGS+IFTAD+ R+L D G+P V+FI +SY ++SG V++L ++R + +H+L
Sbjct: 64 VLKGSFIFTADLARFLADEGVPVRVEFICASSYGEGVETSGQVRMLLDVR-DSVEDRHIL 122
Query: 145 IMEDIADTGRTMKLLVEKIRREYRPASLKVCVLVDKPGGRVVDFKPEFVCLTAPTRYVVG 204
I+EDI D+ T++ L+ + RPASLK VL+DKP R V ++ + P +V+G
Sbjct: 123 IVEDIVDSAITLQYLM-RFMLAKRPASLKTVVLLDKPSRRKVKLLVDYPIIRVPDVFVIG 181
Query: 205 YGFEVNDRYRNYRHVFVLKPEYAKRYPSKL 234
YG + + YR R V LK EY + SKL
Sbjct: 182 YGMDFAESYRELRDVCELKKEYYLKPTSKL 211
>gi|157868946|ref|XP_001683025.1| hypoxanthine-guanine phosphoribosyltransferase [Leishmania major]
gi|68223908|emb|CAJ04328.1| hypoxanthine-guanine phosphoribosyltransferase [Leishmania major]
Length = 211
Score = 137 bits (344), Expect = 8e-31, Method: Composition-based stats.
Identities = 76/210 (36%), Positives = 125/210 (59%), Gaps = 16/210 (7%)
Query: 25 RSYPMAESVVATESTIHRSMKEMAQTLANAYKTLKHRDTHNKGNSALAPITDENPLIIIS 84
R+YPM+ + T+ + + + A+ +A Y++ K +T NPL ++
Sbjct: 18 RNYPMSAHTLVTQEQVWAATAKCAKKIAEDYRSFK--------------LTTGNPLYLLC 63
Query: 85 VLKGSYIFTADMVRYLGDCGLPNVVDFIRITSYRGTTKSSGTVQVLDNLRFTELTGKHVL 144
VLKGS+IFTAD+ R+L D G+P V+FI +SY ++SG V++L ++R + +H+L
Sbjct: 64 VLKGSFIFTADLARFLADEGVPVKVEFICASSYGTGVETSGQVRMLLDVR-DSVENRHIL 122
Query: 145 IMEDIADTGRTMKLLVEKIRREYRPASLKVCVLVDKPGGRVVDFKPEFVCLTAPTRYVVG 204
I+EDI D+ T++ L+ + +PASLK VL+DKP GR V+ ++ +T P +V+G
Sbjct: 123 IVEDIVDSAITLQYLM-RFMLAKKPASLKTVVLLDKPSGRKVEVLVDYPVITIPHAFVIG 181
Query: 205 YGFEVNDRYRNYRHVFVLKPEYAKRYPSKL 234
YG + + YR R + VLK EY ++ SK+
Sbjct: 182 YGMDYAESYRELRDICVLKKEYYEKPESKV 211
>gi|21465599|pdb|1I0I|A Chain A, Analysis Of An Invariant Aspartic Acid In Hprts-Glutamine
Mutant
gi|21465600|pdb|1I0I|B Chain B, Analysis Of An Invariant Aspartic Acid In Hprts-Glutamine
Mutant
Length = 221
Score = 136 bits (343), Expect = 9e-31, Method: Composition-based stats.
Identities = 85/210 (40%), Positives = 122/210 (58%), Gaps = 16/210 (7%)
Query: 25 RSYPMAESVVATESTIHRSMKEMAQTLANAYKTLKHRDTHNKGNSALAPITDENPLIIIS 84
R Y AE ++ TE I +KE+A+ +A+ YK L P NPL++IS
Sbjct: 3 REYEFAEKILFTEEEIRTRIKEVAKRIADDYK-----------GKGLRPYV--NPLVLIS 49
Query: 85 VLKGSYIFTADMVRYLGDCGLPNVVDFIRITSYRGTTKSSGTVQVLDNLRFTELTGKHVL 144
VLKGS++FTAD+ R L D +P ++FI ++SY SSG V++L + R + + G HVL
Sbjct: 50 VLKGSFMFTADLCRALCDFNVPVRMEFICVSSYGEGLTSSGQVRMLLDTRHS-IEGHHVL 108
Query: 145 IMEDIADTGRTMKLLVEKIRREYRPASLKVCVLVDKPGGRVVDFKPEFVCLTAPTRYVVG 204
I+EDI T T+ L + RPASLK VL+DK GR V F ++V P +V+G
Sbjct: 109 IVEDIVQTALTLNYLYH-MYFTRRPASLKTVVLLDKREGRRVPFSADYVVANIPNAFVIG 167
Query: 205 YGFEVNDRYRNYRHVFVLKPE-YAKRYPSK 233
YG + +D YR R + VL+PE YA+R ++
Sbjct: 168 YGLDYDDTYRELRDIVVLRPEVYAEREAAR 197
>gi|21465603|pdb|1I13|A Chain A, Analysis Of An Invariant Aspartic Acid In Hprts-Alanine
Mutant
gi|21465604|pdb|1I13|B Chain B, Analysis Of An Invariant Aspartic Acid In Hprts-Alanine
Mutant
Length = 221
Score = 136 bits (342), Expect = 1e-30, Method: Composition-based stats.
Identities = 85/210 (40%), Positives = 122/210 (58%), Gaps = 16/210 (7%)
Query: 25 RSYPMAESVVATESTIHRSMKEMAQTLANAYKTLKHRDTHNKGNSALAPITDENPLIIIS 84
R Y AE ++ TE I +KE+A+ +A+ YK L P NPL++IS
Sbjct: 3 REYEFAEKILFTEEEIRTRIKEVAKRIADDYK-----------GKGLRPYV--NPLVLIS 49
Query: 85 VLKGSYIFTADMVRYLGDCGLPNVVDFIRITSYRGTTKSSGTVQVLDNLRFTELTGKHVL 144
VLKGS++FTAD+ R L D +P ++FI ++SY SSG V++L + R + + G HVL
Sbjct: 50 VLKGSFMFTADLCRALCDFNVPVRMEFICVSSYGEGLTSSGQVRMLLDTRHS-IEGHHVL 108
Query: 145 IMEDIADTGRTMKLLVEKIRREYRPASLKVCVLVDKPGGRVVDFKPEFVCLTAPTRYVVG 204
I+EDI T T+ L + RPASLK VL+DK GR V F ++V P +V+G
Sbjct: 109 IVEDIVATALTLNYLYH-MYFTRRPASLKTVVLLDKREGRRVPFSADYVVANIPNAFVIG 167
Query: 205 YGFEVNDRYRNYRHVFVLKPE-YAKRYPSK 233
YG + +D YR R + VL+PE YA+R ++
Sbjct: 168 YGLDYDDTYRELRDIVVLRPEVYAEREAAR 197
>gi|116333184|ref|YP_794711.1| Hypoxanthine-guanine phosphoribosyltransferase [Lactobacillus
brevis ATCC 367]
gi|116098531|gb|ABJ63680.1| hypoxanthine phosphoribosyltransferase [Lactobacillus brevis ATCC
367]
Length = 180
Score = 131 bits (329), Expect = 4e-29, Method: Composition-based stats.
Identities = 75/194 (38%), Positives = 118/194 (60%), Gaps = 25/194 (12%)
Query: 31 ESVVATESTIHRSMKEMAQTLANAYKTLKHRDTHNKGNSALAPITDENPLIIISVLKGSY 90
E V+ +E I + K + Q LA Y+ D+ PL++ VLKG+
Sbjct: 6 EKVLYSEEDIAAACKRLGQQLAEDYR-------------------DKTPLMV-CVLKGAI 45
Query: 91 IFTADMVRYLGDCGLPNVVDFIRITSYRGTTKSSGTVQVLDNLRFTELTGKHVLIMEDIA 150
+F D++R D + +DFI ++SY G T+SSGT+++L +L T++ G+ V+++EDI
Sbjct: 46 LFMTDVIR---DMDIYATIDFIDVSSYNGGTESSGTIRLLKDLD-TDVAGRDVVLVEDII 101
Query: 151 DTGRTMKLLVEKIRREYRPASLKVCVLVDKPGGRVVDFKPEFVCLTAPTRYVVGYGFEVN 210
DTGRT+K L E + ++ + S+KVC L+DKP GRVV+ K ++V P+ +VVGYG +
Sbjct: 102 DTGRTLKYL-EDLLKDRQAKSIKVCTLMDKPSGRVVEAKADYVGFNVPSEFVVGYGLDYE 160
Query: 211 DRYRNYRHVFVLKP 224
++YRN +V VLKP
Sbjct: 161 EKYRNLPYVGVLKP 174
>gi|169193152|ref|ZP_02852841.1| hypoxanthine phosphoribosyltransferase [Natranaerobius thermophilus
JW/NM-WN-LF]
gi|169000355|gb|EDS47284.1| hypoxanthine phosphoribosyltransferase [Natranaerobius thermophilus
JW/NM-WN-LF]
Length = 181
Score = 130 bits (328), Expect = 6e-29, Method: Composition-based stats.
Identities = 64/146 (43%), Positives = 98/146 (67%), Gaps = 5/146 (3%)
Query: 80 LIIISVLKGSYIFTADMVRYLGDCGLPNVVDFIRITSYRGTTKSSGTVQVLDNLRFTELT 139
+I + VLKGS++F AD++R L +PN +DF+ ++SY +TKSSG +++L +L T +
Sbjct: 39 VIAVGVLKGSFVFAADLLRQLS---IPNEIDFLAVSSYGASTKSSGIIRILKDLD-TSIE 94
Query: 140 GKHVLIMEDIADTGRTMKLLVEKIRREYRPASLKVCVLVDKPGGRVVDFKPEFVCLTAPT 199
KHVLI+EDI DTG T+ L+E + +PASLK+C L+DKP R VD P+++ P
Sbjct: 95 NKHVLIVEDIVDTGLTLNYLLETLSTR-KPASLKICTLLDKPDRREVDLTPDYIGFQIPD 153
Query: 200 RYVVGYGFEVNDRYRNYRHVFVLKPE 225
+VVGYG + + YR++ ++VL E
Sbjct: 154 LFVVGYGLDYAEYYRDWPAIYVLPEE 179