BLASTP 2.2.17 [Aug-26-2007]
Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Reference for composition-based statistics:
Schäffer, Alejandro A., L. Aravind, Thomas L. Madden,
Schaffer, Alejandro A., L. Aravind, Thomas L. Madden,
Sergei Shavirin, John L. Spouge, Yuri I. Wolf,
Eugene V. Koonin, and Stephen F. Altschul (2001),
"Improving the accuracy of PSI-BLAST protein database searches with
composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005.
Query= XP_822405.1__[Trypanosoma_brucei]
(210 letters)
Database: nr.pal
6,348,806 sequences; 2,166,943,470 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|71746700|ref|XP_822405.1| hypoxanthine-guanine phosphori... 414 e-114
gi|71746686|ref|XP_822398.1| hypoxanthine-guanine phosphori... 408 e-112
gi|71656748|ref|XP_816916.1| hypoxanthine-guanine phosphori... 215 2e-54
gi|49258400|pdb|1P17|A Chain A, Hypoxanthine Phosphoribosyl... 215 2e-54
gi|7245408|pdb|1TC2|A Chain A, Ternary Substrate Complex Of... 214 4e-54
gi|6435813|pdb|1TC1|A Chain A, A 1.4 Angstrom Crystal Struc... 213 5e-54
gi|71649336|ref|XP_813396.1| hypoxanthine-guanine phosphori... 213 6e-54
gi|21465601|pdb|1I0L|A Chain A, Analysis Of An Invariant As... 211 2e-53
gi|21465605|pdb|1I14|A Chain A, Analysis Of An Invariant As... 211 2e-53
gi|21465599|pdb|1I0I|A Chain A, Analysis Of An Invariant As... 211 3e-53
gi|21465603|pdb|1I13|A Chain A, Analysis Of An Invariant As... 210 6e-53
gi|26395149|sp|Q27541|HPRT_CRIFA Hypoxanthine-guanine phosp... 169 1e-40
gi|146080155|ref|XP_001463947.1| HGPRT,hypoxanthine-guanine... 162 2e-38
gi|157868946|ref|XP_001683025.1| hypoxanthine-guanine phosp... 161 3e-38
gi|71746684|ref|XP_822397.1| hypoxanthine-guanine phosphori... 159 8e-38
gi|154337142|ref|XP_001564804.1| hypoxanthine-guanine phosp... 159 2e-37
gi|51247209|pdb|1PZM|A Chain A, Crystal Structure Of Hgprt-... 157 3e-37
gi|91701622|gb|ABE47510.1| hypoxanthine-guanine phosphoribo... 154 4e-36
gi|91701618|gb|ABE47508.1| hypoxanthine-guanine phosphoribo... 153 8e-36
gi|91701620|gb|ABE47509.1| hypoxanthine-guanine phosphoribo... 152 1e-35
gi|71649338|ref|XP_813397.1| hypoxanthine-guanine phosphori... 148 3e-34
gi|71656750|ref|XP_816917.1| hypoxanthine-guanine phosphori... 147 4e-34
gi|154337144|ref|XP_001564805.1| xanthine phosphoribosyltra... 145 1e-33
gi|5759078|gb|AAD50967.1|AF170105_2 xanthine phosphoribosyl... 138 2e-31
gi|7381265|gb|AAF61462.1|AF139722_1 hypoxanthine-guanine ph... 137 6e-31
gi|157868948|ref|XP_001683026.1| xanthine phosphoribosyltra... 136 9e-31
gi|146080158|ref|XP_001463948.1| XRPT, xanthine phosphoribo... 135 1e-30
gi|163782339|ref|ZP_02177337.1| hypoxanthine-guanine phosph... 135 2e-30
gi|158321041|ref|YP_001513548.1| hypoxanthine phosphoribosy... 133 8e-30
gi|147678887|ref|YP_001213102.1| hypoxanthine-guanine phosp... 133 8e-30
gi|134300215|ref|YP_001113711.1| hypoxanthine phosphoribosy... 132 1e-29
gi|119357713|ref|YP_912357.1| hypoxanthine phosphoribosyltr... 132 2e-29
gi|85858559|ref|YP_460761.1| hypoxanthine-guanine phosphori... 132 2e-29
gi|67938140|ref|ZP_00530669.1| Hypoxanthine phosphoribosyl ... 131 2e-29
gi|150389408|ref|YP_001319457.1| hypoxanthine phosphoribosy... 131 2e-29
gi|167729801|emb|CAO80713.1| Hypoxanthine-guanine phosphori... 131 2e-29
gi|145596818|ref|YP_001161115.1| hypoxanthine phosphoribosy... 130 4e-29
gi|159040236|ref|YP_001539489.1| hypoxanthine phosphoribosy... 130 5e-29
gi|158320387|ref|YP_001512894.1| hypoxanthine phosphoribosy... 130 7e-29
gi|51891638|ref|YP_074329.1| hypoxanthine-guanine phosphori... 129 1e-28
gi|121535065|ref|ZP_01666882.1| hypoxanthine phosphoribosyl... 129 2e-28
gi|169193152|ref|ZP_02852841.1| hypoxanthine phosphoribosyl... 129 2e-28
gi|28211841|ref|NP_782785.1| hypoxanthine-guanine phosphori... 129 2e-28
gi|28377430|ref|NP_784322.1| hypoxanthine-guanine phosphori... 128 2e-28
gi|154499605|ref|ZP_02037643.1| hypothetical protein BACCAP... 128 2e-28
gi|160943997|ref|ZP_02091227.1| hypothetical protein FAEPRA... 127 4e-28
gi|168189338|ref|ZP_02623616.1| hypoxanthine phosphoribosyl... 127 6e-28
gi|167628195|ref|YP_001678694.1| hypoxanthine phosphoribosy... 126 9e-28
gi|126700851|ref|YP_001089748.1| hypoxanthine phosphoribosy... 126 1e-27
gi|119714707|ref|YP_921672.1| hypoxanthine phosphoribosyltr... 125 1e-27
gi|145953742|ref|ZP_01802750.1| hypothetical protein CdifQ_... 125 2e-27
gi|168138219|ref|ZP_02581448.1| hypoxanthine phosphoribosyl... 124 3e-27
gi|108805622|ref|YP_645559.1| hypoxanthine phosphoribosyltr... 124 3e-27
gi|75761781|ref|ZP_00741717.1| Hypoxanthine-guanine phospho... 124 3e-27
gi|84495020|ref|ZP_00994139.1| putative hypoxanthine phosph... 124 3e-27
gi|29831208|ref|NP_825842.1| hypoxanthine phosphoribosyltra... 124 3e-27
gi|119025426|ref|YP_909271.1| hypoxanthine-guanine phosphor... 124 3e-27
gi|16273078|ref|NP_439311.1| hypoxanthine-guanine phosphori... 124 4e-27
gi|66809283|ref|XP_638364.1| hypoxanthine phosphoribosyltra... 124 4e-27
gi|159466726|ref|XP_001691549.1| hypothetical protein CHLRE... 124 4e-27
gi|15601986|ref|NP_245058.1| hypoxanthine-guanine phosphori... 124 4e-27
gi|145627876|ref|ZP_01783677.1| hypoxanthine-guanine phosph... 124 5e-27
gi|167938108|ref|ZP_02525183.1| hypoxanthine phosphoribosyl... 124 5e-27
gi|167855570|ref|ZP_02478331.1| hypoxanthine phosphoribosyl... 124 5e-27
gi|29374905|ref|NP_814058.1| hypoxanthine-guanine phosphori... 124 6e-27
gi|78187382|ref|YP_375425.1| Hypoxanthine phosphoribosyl tr... 123 6e-27
gi|150019040|ref|YP_001311294.1| hypoxanthine phosphoribosy... 123 6e-27
gi|148828311|ref|YP_001293064.1| hypoxanthine-guanine phosp... 123 7e-27
gi|150390663|ref|YP_001320712.1| hypoxanthine phosphoribosy... 123 7e-27
gi|46128995|ref|ZP_00155585.2| COG0634: Hypoxanthine-guanin... 123 9e-27
gi|68249702|ref|YP_248814.1| hypoxanthine-guanine phosphori... 123 9e-27
gi|21221832|ref|NP_627611.1| hypoxanthine phosphoribosyltra... 123 9e-27
gi|163938072|ref|YP_001642956.1| hypoxanthine phosphoribosy... 123 1e-26
gi|68552907|ref|ZP_00592291.1| Hypoxanthine phosphoribosyl ... 122 1e-26
gi|69245449|ref|ZP_00603444.1| Hypoxanthine phosphoribosyl ... 122 1e-26
gi|167465128|ref|ZP_02330217.1| hypothetical protein Plarl_... 122 1e-26
gi|145633117|ref|ZP_01788849.1| hypoxanthine-guanine phosph... 122 1e-26
gi|30018335|ref|NP_829966.1| hypoxanthine-guanine phosphori... 122 2e-26
gi|168264858|ref|ZP_02686823.1| hypothetical protein LmonFS... 122 2e-26
gi|42631455|ref|ZP_00156993.1| COG0634: Hypoxanthine-guanin... 122 2e-26
gi|15606004|ref|NP_213381.1| hypoxanthine-guanine phosphori... 122 2e-26
gi|167013674|ref|ZP_02276207.1| hypothetical protein LmonFS... 122 2e-26
gi|152973912|ref|YP_001373429.1| hypoxanthine phosphoribosy... 122 2e-26
gi|16802265|ref|NP_463750.1| fusion protein, N-terminal par... 122 2e-26
gi|153172864|ref|ZP_01928838.1| tRNA(Ile)-lysidine syntheta... 122 2e-26
gi|47093161|ref|ZP_00230936.1| conserved hypothetical prote... 122 2e-26
gi|153165181|ref|ZP_01926199.1| tRNA(Ile)-lysidine syntheta... 122 2e-26
gi|46906451|ref|YP_012840.1| conserved hypothetical protein... 122 2e-26
gi|166997010|ref|ZP_02263469.1| hypoxanthine phosphoribosyl... 122 2e-26
gi|30260255|ref|NP_842632.1| hypoxanthine-guanine phosphori... 122 2e-26
gi|153198228|ref|ZP_01942347.1| tRNA(Ile)-lysidine syntheta... 122 2e-26
gi|16799328|ref|NP_469596.1| fusion protein, N-terminal par... 122 2e-26
gi|126208162|ref|YP_001053387.1| yypoxanthine phosphoribosy... 121 2e-26
gi|53729184|ref|ZP_00134029.2| COG0634: Hypoxanthine-guanin... 121 2e-26
gi|168190944|ref|ZP_02625222.1| hypoxanthine phosphoribosyl... 121 3e-26
gi|41393671|gb|AAS02076.1| hypoxanthine-guanine phosphoribo... 121 3e-26
gi|169825697|ref|YP_001695855.1| Hypoxanthine-guanine phosp... 121 3e-26
gi|116871602|ref|YP_848383.1| conserved hypothetical/hypoxa... 121 3e-26
gi|145635605|ref|ZP_01791303.1| hypoxanthine-guanine phosph... 121 3e-26
gi|88854793|ref|ZP_01129459.1| hypoxanthine phosphoribosylt... 121 3e-26
>gi|71746700|ref|XP_822405.1| hypoxanthine-guanine phosphoribosyltransferase [Trypanosoma brucei]
gi|70832073|gb|EAN77577.1| hypoxanthine-guanine phosphoribosyltransferase [Trypanosoma brucei]
Length = 210
Score = 414 bits (1065), Expect = e-114, Method: Composition-based stats.
Identities = 210/210 (100%), Positives = 210/210 (100%)
Query: 1 MEPACKYDFATSVLFTEAELHTRMRGVAQRIADDYSNCNLKPLENPLVVVSVLRGSFVFT 60
MEPACKYDFATSVLFTEAELHTRMRGVAQRIADDYSNCNLKPLENPLVVVSVLRGSFVFT
Sbjct: 1 MEPACKYDFATSVLFTEAELHTRMRGVAQRIADDYSNCNLKPLENPLVVVSVLRGSFVFT 60
Query: 61 ADMVRILGDFGVPTRVEFLRASSYGHDTKSCGRVDVKADGLCDIRGKHVLVLEDILDTAL 120
ADMVRILGDFGVPTRVEFLRASSYGHDTKSCGRVDVKADGLCDIRGKHVLVLEDILDTAL
Sbjct: 61 ADMVRILGDFGVPTRVEFLRASSYGHDTKSCGRVDVKADGLCDIRGKHVLVLEDILDTAL 120
Query: 121 TLREVVDSLKKSEPASIKTLVAIDKPGGRKIPFTAEYVVADVPNVFVVGYGLDYDQSYRE 180
TLREVVDSLKKSEPASIKTLVAIDKPGGRKIPFTAEYVVADVPNVFVVGYGLDYDQSYRE
Sbjct: 121 TLREVVDSLKKSEPASIKTLVAIDKPGGRKIPFTAEYVVADVPNVFVVGYGLDYDQSYRE 180
Query: 181 VRDVVILKPSVYETWGKELERRKAAVKAKL 210
VRDVVILKPSVYETWGKELERRKAAVKAKL
Sbjct: 181 VRDVVILKPSVYETWGKELERRKAAVKAKL 210
>gi|71746686|ref|XP_822398.1| hypoxanthine-guanine phosphoribosyltransferase [Trypanosoma brucei]
gi|547672|sp|Q07010|HPRT_TRYBB Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) (HGPRTase)
gi|162105|gb|AAA16328.1| hypoxanthine-guanine phosphoribosyltransferase
gi|70832066|gb|EAN77570.1| hypoxanthine-guanine phosphoribosyltransferase [Trypanosoma brucei]
Length = 210
Score = 408 bits (1048), Expect = e-112, Method: Composition-based stats.
Identities = 205/209 (98%), Positives = 208/209 (99%)
Query: 1 MEPACKYDFATSVLFTEAELHTRMRGVAQRIADDYSNCNLKPLENPLVVVSVLRGSFVFT 60
MEPACKYDFATSVLFTEAELHTRMRGVAQRIADDYSNCNLKPLENPLV+VSVL+GSFVFT
Sbjct: 1 MEPACKYDFATSVLFTEAELHTRMRGVAQRIADDYSNCNLKPLENPLVIVSVLKGSFVFT 60
Query: 61 ADMVRILGDFGVPTRVEFLRASSYGHDTKSCGRVDVKADGLCDIRGKHVLVLEDILDTAL 120
ADMVRILGDFGVPTRVEFLRASSYGHDTKSCGRVDVKADGLCDIRGKHVLVLEDILDTAL
Sbjct: 61 ADMVRILGDFGVPTRVEFLRASSYGHDTKSCGRVDVKADGLCDIRGKHVLVLEDILDTAL 120
Query: 121 TLREVVDSLKKSEPASIKTLVAIDKPGGRKIPFTAEYVVADVPNVFVVGYGLDYDQSYRE 180
TLREVVDSLKKSEPASIKTLVAIDKPGGRKIPFTAEYVVADVPNVFVVGYGLDYDQSYRE
Sbjct: 121 TLREVVDSLKKSEPASIKTLVAIDKPGGRKIPFTAEYVVADVPNVFVVGYGLDYDQSYRE 180
Query: 181 VRDVVILKPSVYETWGKELERRKAAVKAK 209
VRDVVILKPSVYETWGKELERRKAA +AK
Sbjct: 181 VRDVVILKPSVYETWGKELERRKAAGEAK 209
>gi|71656748|ref|XP_816916.1| hypoxanthine-guanine phosphoribosyltransferase, putative
[Trypanosoma cruzi strain CL Brener]
gi|70882076|gb|EAN95065.1| hypoxanthine-guanine phosphoribosyltransferase, putative
[Trypanosoma cruzi]
Length = 241
Score = 215 bits (547), Expect = 2e-54, Method: Composition-based stats.
Identities = 104/201 (51%), Positives = 145/201 (72%)
Query: 6 KYDFATSVLFTEAELHTRMRGVAQRIADDYSNCNLKPLENPLVVVSVLRGSFVFTADMVR 65
+Y+FA +LFTE E+ TR++ VA+RIADDY L+P NPLV++SVL+GSF+FTAD+ R
Sbjct: 24 EYEFAEKILFTEEEIRTRIKEVAKRIADDYKGKGLRPYVNPLVLISVLKGSFMFTADLCR 83
Query: 66 ILGDFGVPTRVEFLRASSYGHDTKSCGRVDVKADGLCDIRGKHVLVLEDILDTALTLREV 125
L DF VP R+EF+ SSYG S G+V + D I G HVL++EDI+DTALTL +
Sbjct: 84 ALCDFNVPVRMEFICVSSYGEGLTSSGQVRMLLDTRHSIEGHHVLIVEDIVDTALTLNYL 143
Query: 126 VDSLKKSEPASIKTLVAIDKPGGRKIPFTAEYVVADVPNVFVVGYGLDYDQSYREVRDVV 185
PAS+KT+V +DK GR++PF+A+YVVA++PN FV+GYGLDYD +YRE+RD+V
Sbjct: 144 YHMYFTRRPASLKTVVLLDKREGRRVPFSADYVVANIPNAFVIGYGLDYDDTYRELRDIV 203
Query: 186 ILKPSVYETWGKELERRKAAV 206
+L+P VY ++++ A+
Sbjct: 204 VLRPEVYAEREAARQKKQRAI 224
>gi|49258400|pdb|1P17|A Chain A, Hypoxanthine Phosphoribosyltransferase From Trypanosoma
Cruzi, K68r Mutant, Complexed With The Product Imp
gi|49258401|pdb|1P17|B Chain B, Hypoxanthine Phosphoribosyltransferase From Trypanosoma
Cruzi, K68r Mutant, Complexed With The Product Imp
gi|49258402|pdb|1P17|C Chain C, Hypoxanthine Phosphoribosyltransferase From Trypanosoma
Cruzi, K68r Mutant, Complexed With The Product Imp
gi|49258403|pdb|1P17|D Chain D, Hypoxanthine Phosphoribosyltransferase From Trypanosoma
Cruzi, K68r Mutant, Complexed With The Product Imp
gi|49258404|pdb|1P18|A Chain A, Hypoxanthine Phosphoribosyltransferase From Trypanosoma
Cruzi, K68r Mutant, Ternary Substrates Complex
gi|49258405|pdb|1P18|B Chain B, Hypoxanthine Phosphoribosyltransferase From Trypanosoma
Cruzi, K68r Mutant, Ternary Substrates Complex
Length = 221
Score = 215 bits (547), Expect = 2e-54, Method: Composition-based stats.
Identities = 105/201 (52%), Positives = 145/201 (72%)
Query: 6 KYDFATSVLFTEAELHTRMRGVAQRIADDYSNCNLKPLENPLVVVSVLRGSFVFTADMVR 65
+Y+FA +LFTE E+ TR++ VA+RIADDY L+P NPLV++SVLRGSF+FTAD+ R
Sbjct: 4 EYEFAEKILFTEEEIRTRIKEVAKRIADDYKGKGLRPYVNPLVLISVLRGSFMFTADLCR 63
Query: 66 ILGDFGVPTRVEFLRASSYGHDTKSCGRVDVKADGLCDIRGKHVLVLEDILDTALTLREV 125
L DF VP R+EF+ SSYG S G+V + D I G HVL++EDI+DTALTL +
Sbjct: 64 ALCDFNVPVRMEFICVSSYGEGLTSSGQVRMLLDTRHSIEGHHVLIVEDIVDTALTLNYL 123
Query: 126 VDSLKKSEPASIKTLVAIDKPGGRKIPFTAEYVVADVPNVFVVGYGLDYDQSYREVRDVV 185
PAS+KT+V +DK GR++PF+A+YVVA++PN FV+GYGLDYD +YRE+RD+V
Sbjct: 124 YHMYFTRRPASLKTVVLLDKREGRRVPFSADYVVANIPNAFVIGYGLDYDDTYRELRDIV 183
Query: 186 ILKPSVYETWGKELERRKAAV 206
+L+P VY ++++ A+
Sbjct: 184 VLRPEVYAEREAARQKKQRAI 204
>gi|7245408|pdb|1TC2|A Chain A, Ternary Substrate Complex Of The Hypoxanthine
Phosphoribosyltransferase From Trypanosoma Cruzi
gi|7245409|pdb|1TC2|B Chain B, Ternary Substrate Complex Of The Hypoxanthine
Phosphoribosyltransferase From Trypanosoma Cruzi
gi|49258406|pdb|1P19|A Chain A, Hypoxanthine Phosphoribosyltransferase From Trypanosoma
Cruzi, In Complex With The Product Imp
gi|49258407|pdb|1P19|B Chain B, Hypoxanthine Phosphoribosyltransferase From Trypanosoma
Cruzi, In Complex With The Product Imp
gi|49258408|pdb|1P19|C Chain C, Hypoxanthine Phosphoribosyltransferase From Trypanosoma
Cruzi, In Complex With The Product Imp
gi|49258409|pdb|1P19|D Chain D, Hypoxanthine Phosphoribosyltransferase From Trypanosoma
Cruzi, In Complex With The Product Imp
Length = 221
Score = 214 bits (544), Expect = 4e-54, Method: Composition-based stats.
Identities = 104/201 (51%), Positives = 145/201 (72%)
Query: 6 KYDFATSVLFTEAELHTRMRGVAQRIADDYSNCNLKPLENPLVVVSVLRGSFVFTADMVR 65
+Y+FA +LFTE E+ TR++ VA+RIADDY L+P NPLV++SVL+GSF+FTAD+ R
Sbjct: 4 EYEFAEKILFTEEEIRTRIKEVAKRIADDYKGKGLRPYVNPLVLISVLKGSFMFTADLCR 63
Query: 66 ILGDFGVPTRVEFLRASSYGHDTKSCGRVDVKADGLCDIRGKHVLVLEDILDTALTLREV 125
L DF VP R+EF+ SSYG S G+V + D I G HVL++EDI+DTALTL +
Sbjct: 64 ALCDFNVPVRMEFICVSSYGEGLTSSGQVRMLLDTRHSIEGHHVLIVEDIVDTALTLNYL 123
Query: 126 VDSLKKSEPASIKTLVAIDKPGGRKIPFTAEYVVADVPNVFVVGYGLDYDQSYREVRDVV 185
PAS+KT+V +DK GR++PF+A+YVVA++PN FV+GYGLDYD +YRE+RD+V
Sbjct: 124 YHMYFTRRPASLKTVVLLDKREGRRVPFSADYVVANIPNAFVIGYGLDYDDTYRELRDIV 183
Query: 186 ILKPSVYETWGKELERRKAAV 206
+L+P VY ++++ A+
Sbjct: 184 VLRPEVYAEREAARQKKQRAI 204
>gi|6435813|pdb|1TC1|A Chain A, A 1.4 Angstrom Crystal Structure For The Hypoxanthine
Phosphoribosyltransferase Of Trypanosoma Cruzi
gi|6435814|pdb|1TC1|B Chain B, A 1.4 Angstrom Crystal Structure For The Hypoxanthine
Phosphoribosyltransferase Of Trypanosoma Cruzi
Length = 220
Score = 213 bits (543), Expect = 5e-54, Method: Composition-based stats.
Identities = 104/201 (51%), Positives = 145/201 (72%)
Query: 6 KYDFATSVLFTEAELHTRMRGVAQRIADDYSNCNLKPLENPLVVVSVLRGSFVFTADMVR 65
+Y+FA +LFTE E+ TR++ VA+RIADDY L+P NPLV++SVL+GSF+FTAD+ R
Sbjct: 3 EYEFAEKILFTEEEIRTRIKEVAKRIADDYKGKGLRPYVNPLVLISVLKGSFMFTADLCR 62
Query: 66 ILGDFGVPTRVEFLRASSYGHDTKSCGRVDVKADGLCDIRGKHVLVLEDILDTALTLREV 125
L DF VP R+EF+ SSYG S G+V + D I G HVL++EDI+DTALTL +
Sbjct: 63 ALCDFNVPVRMEFICVSSYGEGLTSSGQVRMLLDTRHSIEGHHVLIVEDIVDTALTLNYL 122
Query: 126 VDSLKKSEPASIKTLVAIDKPGGRKIPFTAEYVVADVPNVFVVGYGLDYDQSYREVRDVV 185
PAS+KT+V +DK GR++PF+A+YVVA++PN FV+GYGLDYD +YRE+RD+V
Sbjct: 123 YHMYFTRRPASLKTVVLLDKREGRRVPFSADYVVANIPNAFVIGYGLDYDDTYRELRDIV 182
Query: 186 ILKPSVYETWGKELERRKAAV 206
+L+P VY ++++ A+
Sbjct: 183 VLRPEVYAEREAARQKKQRAI 203
>gi|71649336|ref|XP_813396.1| hypoxanthine-guanine phosphoribosyltransferase, putative
[Trypanosoma cruzi strain CL Brener]
gi|386724|gb|AAB46391.1| hypoxanthine-guanine phosphoribosyltransferase
gi|70878274|gb|EAN91545.1| hypoxanthine-guanine phosphoribosyltransferase, putative
[Trypanosoma cruzi]
Length = 221
Score = 213 bits (543), Expect = 6e-54, Method: Composition-based stats.
Identities = 104/201 (51%), Positives = 144/201 (71%)
Query: 6 KYDFATSVLFTEAELHTRMRGVAQRIADDYSNCNLKPLENPLVVVSVLRGSFVFTADMVR 65
+Y+FA +LFTE E+ TR+ VA+RIADDY L+P NPLV++SVL+GSF+FTAD+ R
Sbjct: 4 EYEFAEKILFTEEEIRTRIMEVAKRIADDYKGKGLRPYVNPLVLISVLKGSFMFTADLCR 63
Query: 66 ILGDFGVPTRVEFLRASSYGHDTKSCGRVDVKADGLCDIRGKHVLVLEDILDTALTLREV 125
L DF VP R+EF+ SSYG S G+V + D I G HVL++EDI+DTALTL +
Sbjct: 64 ALSDFNVPVRMEFICVSSYGEGVTSSGQVRMLLDTRHSIEGHHVLIVEDIVDTALTLNYL 123
Query: 126 VDSLKKSEPASIKTLVAIDKPGGRKIPFTAEYVVADVPNVFVVGYGLDYDQSYREVRDVV 185
PAS+KT+V +DK GR++PF+A+YVVA++PN FV+GYGLDYD +YRE+RD+V
Sbjct: 124 YHMYFTRRPASLKTVVLLDKREGRRVPFSADYVVANIPNAFVIGYGLDYDDTYRELRDIV 183
Query: 186 ILKPSVYETWGKELERRKAAV 206
+L+P VY ++++ A+
Sbjct: 184 VLRPEVYAEREAARQKKQRAI 204
>gi|21465601|pdb|1I0L|A Chain A, Analysis Of An Invariant Aspartic Acid In Hprts-Asparagine
Mutant
gi|21465602|pdb|1I0L|B Chain B, Analysis Of An Invariant Aspartic Acid In Hprts-Asparagine
Mutant
Length = 221
Score = 211 bits (538), Expect = 2e-53, Method: Composition-based stats.
Identities = 102/187 (54%), Positives = 139/187 (74%)
Query: 6 KYDFATSVLFTEAELHTRMRGVAQRIADDYSNCNLKPLENPLVVVSVLRGSFVFTADMVR 65
+Y+FA +LFTE E+ TR++ VA+RIADDY L+P NPLV++SVL+GSF+FTAD+ R
Sbjct: 4 EYEFAEKILFTEEEIRTRIKEVAKRIADDYKGKGLRPYVNPLVLISVLKGSFMFTADLCR 63
Query: 66 ILGDFGVPTRVEFLRASSYGHDTKSCGRVDVKADGLCDIRGKHVLVLEDILDTALTLREV 125
L DF VP R+EF+ SSYG S G+V + D I G HVL++EDI++TALTL +
Sbjct: 64 ALCDFNVPVRMEFICVSSYGEGLTSSGQVRMLLDTRHSIEGHHVLIVEDIVNTALTLNYL 123
Query: 126 VDSLKKSEPASIKTLVAIDKPGGRKIPFTAEYVVADVPNVFVVGYGLDYDQSYREVRDVV 185
PAS+KT+V +DK GR++PF+A+YVVA++PN FV+GYGLDYD +YRE+RD+V
Sbjct: 124 YHMYFTRRPASLKTVVLLDKREGRRVPFSADYVVANIPNAFVIGYGLDYDDTYRELRDIV 183
Query: 186 ILKPSVY 192
+L+P VY
Sbjct: 184 VLRPEVY 190
>gi|21465605|pdb|1I14|A Chain A, Analysis Of An Invariant Aspartic Acid In Hprts-Glutamic
Acid Mutant
gi|21465606|pdb|1I14|B Chain B, Analysis Of An Invariant Aspartic Acid In Hprts-Glutamic
Acid Mutant
Length = 221
Score = 211 bits (537), Expect = 2e-53, Method: Composition-based stats.
Identities = 102/187 (54%), Positives = 139/187 (74%)
Query: 6 KYDFATSVLFTEAELHTRMRGVAQRIADDYSNCNLKPLENPLVVVSVLRGSFVFTADMVR 65
+Y+FA +LFTE E+ TR++ VA+RIADDY L+P NPLV++SVL+GSF+FTAD+ R
Sbjct: 4 EYEFAEKILFTEEEIRTRIKEVAKRIADDYKGKGLRPYVNPLVLISVLKGSFMFTADLCR 63
Query: 66 ILGDFGVPTRVEFLRASSYGHDTKSCGRVDVKADGLCDIRGKHVLVLEDILDTALTLREV 125
L DF VP R+EF+ SSYG S G+V + D I G HVL++EDI++TALTL +
Sbjct: 64 ALCDFNVPVRMEFICVSSYGEGLTSSGQVRMLLDTRHSIEGHHVLIVEDIVETALTLNYL 123
Query: 126 VDSLKKSEPASIKTLVAIDKPGGRKIPFTAEYVVADVPNVFVVGYGLDYDQSYREVRDVV 185
PAS+KT+V +DK GR++PF+A+YVVA++PN FV+GYGLDYD +YRE+RD+V
Sbjct: 124 YHMYFTRRPASLKTVVLLDKREGRRVPFSADYVVANIPNAFVIGYGLDYDDTYRELRDIV 183
Query: 186 ILKPSVY 192
+L+P VY
Sbjct: 184 VLRPEVY 190
>gi|21465599|pdb|1I0I|A Chain A, Analysis Of An Invariant Aspartic Acid In Hprts-Glutamine
Mutant
gi|21465600|pdb|1I0I|B Chain B, Analysis Of An Invariant Aspartic Acid In Hprts-Glutamine
Mutant
Length = 221
Score = 211 bits (536), Expect = 3e-53, Method: Composition-based stats.
Identities = 102/187 (54%), Positives = 138/187 (73%)
Query: 6 KYDFATSVLFTEAELHTRMRGVAQRIADDYSNCNLKPLENPLVVVSVLRGSFVFTADMVR 65
+Y+FA +LFTE E+ TR++ VA+RIADDY L+P NPLV++SVL+GSF+FTAD+ R
Sbjct: 4 EYEFAEKILFTEEEIRTRIKEVAKRIADDYKGKGLRPYVNPLVLISVLKGSFMFTADLCR 63
Query: 66 ILGDFGVPTRVEFLRASSYGHDTKSCGRVDVKADGLCDIRGKHVLVLEDILDTALTLREV 125
L DF VP R+EF+ SSYG S G+V + D I G HVL++EDI+ TALTL +
Sbjct: 64 ALCDFNVPVRMEFICVSSYGEGLTSSGQVRMLLDTRHSIEGHHVLIVEDIVQTALTLNYL 123
Query: 126 VDSLKKSEPASIKTLVAIDKPGGRKIPFTAEYVVADVPNVFVVGYGLDYDQSYREVRDVV 185
PAS+KT+V +DK GR++PF+A+YVVA++PN FV+GYGLDYD +YRE+RD+V
Sbjct: 124 YHMYFTRRPASLKTVVLLDKREGRRVPFSADYVVANIPNAFVIGYGLDYDDTYRELRDIV 183
Query: 186 ILKPSVY 192
+L+P VY
Sbjct: 184 VLRPEVY 190
>gi|21465603|pdb|1I13|A Chain A, Analysis Of An Invariant Aspartic Acid In Hprts-Alanine
Mutant
gi|21465604|pdb|1I13|B Chain B, Analysis Of An Invariant Aspartic Acid In Hprts-Alanine
Mutant
Length = 221
Score = 210 bits (534), Expect = 6e-53, Method: Composition-based stats.
Identities = 102/187 (54%), Positives = 138/187 (73%)
Query: 6 KYDFATSVLFTEAELHTRMRGVAQRIADDYSNCNLKPLENPLVVVSVLRGSFVFTADMVR 65
+Y+FA +LFTE E+ TR++ VA+RIADDY L+P NPLV++SVL+GSF+FTAD+ R
Sbjct: 4 EYEFAEKILFTEEEIRTRIKEVAKRIADDYKGKGLRPYVNPLVLISVLKGSFMFTADLCR 63
Query: 66 ILGDFGVPTRVEFLRASSYGHDTKSCGRVDVKADGLCDIRGKHVLVLEDILDTALTLREV 125
L DF VP R+EF+ SSYG S G+V + D I G HVL++EDI+ TALTL +
Sbjct: 64 ALCDFNVPVRMEFICVSSYGEGLTSSGQVRMLLDTRHSIEGHHVLIVEDIVATALTLNYL 123
Query: 126 VDSLKKSEPASIKTLVAIDKPGGRKIPFTAEYVVADVPNVFVVGYGLDYDQSYREVRDVV 185
PAS+KT+V +DK GR++PF+A+YVVA++PN FV+GYGLDYD +YRE+RD+V
Sbjct: 124 YHMYFTRRPASLKTVVLLDKREGRRVPFSADYVVANIPNAFVIGYGLDYDDTYRELRDIV 183
Query: 186 ILKPSVY 192
+L+P VY
Sbjct: 184 VLRPEVY 190
>gi|26395149|sp|Q27541|HPRT_CRIFA Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) (HGPRTase)
gi|643084|gb|AAB04164.1| hypoxanthine-guanine phophoribosyltransferase
Length = 208
Score = 169 bits (427), Expect = 1e-40, Method: Composition-based stats.
Identities = 84/193 (43%), Positives = 128/193 (66%), Gaps = 1/193 (0%)
Query: 7 YDFATSVLFTEAELHTRMRGVAQRIADDYSNCNLKPLENPLVVVSVLRGSFVFTADMVRI 66
Y + L T+ ++ + A++IA+DY NL ENPL ++ VL+GSF+FTAD+ R
Sbjct: 17 YPMSCRTLATQEQIWSATAKCAKQIAEDYKQYNLSD-ENPLYLLCVLKGSFMFTADLARF 75
Query: 67 LGDFGVPTRVEFLRASSYGHDTKSCGRVDVKADGLCDIRGKHVLVLEDILDTALTLREVV 126
L D GVP R+EF+ ASSYG D K+ G V + D + +H+L++EDI+D+A+TL +
Sbjct: 76 LCDEGVPVRIEFICASSYGTDVKTSGEVRLLLDVRDPVENRHLLIVEDIVDSAITLEYLK 135
Query: 127 DSLKKSEPASIKTLVAIDKPGGRKIPFTAEYVVADVPNVFVVGYGLDYDQSYREVRDVVI 186
L+ +PAS+KT+V +DKP GRK+ + +Y V +P+ FV+GYG+D+ ++YRE+RDV +
Sbjct: 136 RFLQAKQPASLKTVVLLDKPSGRKVTLSVDYPVITIPHAFVIGYGMDFAEAYRELRDVCV 195
Query: 187 LKPSVYETWGKEL 199
LK YE +L
Sbjct: 196 LKKEYYEKPASKL 208
>gi|146080155|ref|XP_001463947.1| HGPRT,hypoxanthine-guanine phosphoribosynthesis protein [Leishmania
infantum JPCM5]
gi|1170359|sp|P43152|HPRT_LEIDO Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) (HGPRTase)
gi|5759077|gb|AAD50966.1|AF170105_1 hypoxanthine-guanine phosphoribosyltransferase HGPRT [Leishmania
donovani]
gi|409144|gb|AAB00074.1| hypoxanthine-guanine phosphoribosyltransferase
gi|134068036|emb|CAM66321.1| HGPRT,hypoxanthine-guanine phosphoribosynthesis protein [Leishmania
infantum]
Length = 211
Score = 162 bits (409), Expect = 2e-38, Method: Composition-based stats.
Identities = 79/187 (42%), Positives = 125/187 (66%), Gaps = 1/187 (0%)
Query: 7 YDFATSVLFTEAELHTRMRGVAQRIADDYSNCNLKPLENPLVVVSVLRGSFVFTADMVRI 66
Y + L T+ ++ A++IA+DY + L +NPL ++ VL+GSF+FTAD+ R
Sbjct: 20 YPMSAHTLVTQEQVWAATAKCAKKIAEDYRSFKLTT-DNPLYLLCVLKGSFIFTADLARF 78
Query: 67 LGDFGVPTRVEFLRASSYGHDTKSCGRVDVKADGLCDIRGKHVLVLEDILDTALTLREVV 126
L D GVP +VEF+ ASSYG ++ G+V + D + +H+L++EDI+D+A+TL+ ++
Sbjct: 79 LADEGVPVKVEFICASSYGTGVETSGQVRMLLDVRDSVENRHILIVEDIVDSAITLQYLM 138
Query: 127 DSLKKSEPASIKTLVAIDKPGGRKIPFTAEYVVADVPNVFVVGYGLDYDQSYREVRDVVI 186
+ +PAS+KT+V +DKP GRK+ +Y V +P+ FV+GYG+DY +SYRE+RD+ +
Sbjct: 139 RFMLAKKPASLKTVVLLDKPSGRKVEVLVDYPVITIPHAFVIGYGMDYAESYRELRDICV 198
Query: 187 LKPSVYE 193
LK YE
Sbjct: 199 LKKEYYE 205
>gi|157868946|ref|XP_001683025.1| hypoxanthine-guanine phosphoribosyltransferase [Leishmania major]
gi|68223908|emb|CAJ04328.1| hypoxanthine-guanine phosphoribosyltransferase [Leishmania major]
Length = 211
Score = 161 bits (407), Expect = 3e-38, Method: Composition-based stats.
Identities = 79/187 (42%), Positives = 124/187 (66%), Gaps = 1/187 (0%)
Query: 7 YDFATSVLFTEAELHTRMRGVAQRIADDYSNCNLKPLENPLVVVSVLRGSFVFTADMVRI 66
Y + L T+ ++ A++IA+DY + L NPL ++ VL+GSF+FTAD+ R
Sbjct: 20 YPMSAHTLVTQEQVWAATAKCAKKIAEDYRSFKLTT-GNPLYLLCVLKGSFIFTADLARF 78
Query: 67 LGDFGVPTRVEFLRASSYGHDTKSCGRVDVKADGLCDIRGKHVLVLEDILDTALTLREVV 126
L D GVP +VEF+ ASSYG ++ G+V + D + +H+L++EDI+D+A+TL+ ++
Sbjct: 79 LADEGVPVKVEFICASSYGTGVETSGQVRMLLDVRDSVENRHILIVEDIVDSAITLQYLM 138
Query: 127 DSLKKSEPASIKTLVAIDKPGGRKIPFTAEYVVADVPNVFVVGYGLDYDQSYREVRDVVI 186
+ +PAS+KT+V +DKP GRK+ +Y V +P+ FV+GYG+DY +SYRE+RD+ +
Sbjct: 139 RFMLAKKPASLKTVVLLDKPSGRKVEVLVDYPVITIPHAFVIGYGMDYAESYRELRDICV 198
Query: 187 LKPSVYE 193
LK YE
Sbjct: 199 LKKEYYE 205
>gi|71746684|ref|XP_822397.1| hypoxanthine-guanine phosphoribosyltransferase [Trypanosoma brucei]
gi|70832065|gb|EAN77569.1| hypoxanthine-guanine phosphoribosyltransferase, putative
[Trypanosoma brucei]
Length = 234
Score = 159 bits (403), Expect = 8e-38, Method: Composition-based stats.
Identities = 89/209 (42%), Positives = 129/209 (61%), Gaps = 17/209 (8%)
Query: 7 YDFATSVLFTEAELHTRMRGVAQRIADDYS-----------NCNLKPL--ENPLVVVSVL 53
Y A SV+ TE+ +H M+ +AQ +A+ Y N L P+ ENPL+++SVL
Sbjct: 27 YPMAESVVATESTIHRSMKEMAQTLANAYKTLKHRDTHNKGNSALAPITDENPLIIISVL 86
Query: 54 RGSFVFTADMVRILGDFGVPTRVEFLRASSYGHDTKSCGRVDVKADGL--CDIRGKHVLV 111
+GS++FTADMVR LGD G+P V+F+R +SY TKS G V V D L ++ GKHVL+
Sbjct: 87 KGSYIFTADMVRYLGDCGLPNVVDFIRITSYRGTTKSSGTVQV-LDNLRFTELTGKHVLI 145
Query: 112 LEDILDTALTLREVVDSLKKS-EPASIKTLVAIDKPGGRKIPFTAEYVVADVPNVFVVGY 170
+EDI DT T++ +V+ +++ PAS+K V +DKPGGR + F E+V P +VVGY
Sbjct: 146 MEDIADTGRTMKLLVEKIRREYRPASLKVCVLVDKPGGRVVDFKPEFVCLTAPTRYVVGY 205
Query: 171 GLDYDQSYREVRDVVILKPSVYETWGKEL 199
G + + YR R V +LKP + + +L
Sbjct: 206 GFEVNDRYRNYRHVFVLKPEYAKRYPSKL 234
>gi|154337142|ref|XP_001564804.1| hypoxanthine-guanine phosphoribosyltransferase [Leishmania
braziliensis MHOM/BR/75/M2904]
gi|134061842|emb|CAM38879.1| hypoxanthine-guanine phosphoribosyltransferase [Leishmania
braziliensis]
Length = 211
Score = 159 bits (401), Expect = 2e-37, Method: Composition-based stats.
Identities = 80/186 (43%), Positives = 120/186 (64%), Gaps = 1/186 (0%)
Query: 7 YDFATSVLFTEAELHTRMRGVAQRIADDYSNCNLKPLENPLVVVSVLRGSFVFTADMVRI 66
Y + + T+ ++ A+ IA DY L P ENPL ++ VL+GSF+FTAD+ R
Sbjct: 20 YPMSARTVITQEQVWAATAQCAKTIAQDYEKFKLAP-ENPLYLLCVLKGSFIFTADLARF 78
Query: 67 LGDFGVPTRVEFLRASSYGHDTKSCGRVDVKADGLCDIRGKHVLVLEDILDTALTLREVV 126
L D GVP RVEF+ ASSYG ++ G+V + D + +H+L++EDI+D+A+TL+ ++
Sbjct: 79 LADEGVPVRVEFICASSYGEGVETSGQVRMLLDVRDSVEDRHILIVEDIVDSAITLQYLM 138
Query: 127 DSLKKSEPASIKTLVAIDKPGGRKIPFTAEYVVADVPNVFVVGYGLDYDQSYREVRDVVI 186
+ PAS+KT+V +DKP RK+ +Y + VP+VFV+GYG+D+ +SYRE+RDV
Sbjct: 139 RFMLAKRPASLKTVVLLDKPSRRKVKLLVDYPIIRVPDVFVIGYGMDFAESYRELRDVCE 198
Query: 187 LKPSVY 192
LK Y
Sbjct: 199 LKKEYY 204
>gi|51247209|pdb|1PZM|A Chain A, Crystal Structure Of Hgprt-Ase From Leishmania Tarentolae
In Complex With Gmp
gi|51247210|pdb|1PZM|B Chain B, Crystal Structure Of Hgprt-Ase From Leishmania Tarentolae
In Complex With Gmp
Length = 211
Score = 157 bits (398), Expect = 3e-37, Method: Composition-based stats.
Identities = 77/187 (41%), Positives = 124/187 (66%), Gaps = 1/187 (0%)
Query: 7 YDFATSVLFTEAELHTRMRGVAQRIADDYSNCNLKPLENPLVVVSVLRGSFVFTADMVRI 66
Y + L T+ ++ A++IA DY + +L +NPL ++ VL+GSF+FTAD+ R
Sbjct: 20 YPMSARTLVTQEQVWAATAKCAKKIAADYKDFHLTA-DNPLYLLCVLKGSFIFTADLARF 78
Query: 67 LGDFGVPTRVEFLRASSYGHDTKSCGRVDVKADGLCDIRGKHVLVLEDILDTALTLREVV 126
L D GVP +VEF+ ASSYG ++ G+V + D + +H++++EDI+D+A+TL+ ++
Sbjct: 79 LADEGVPVKVEFICASSYGSGVETSGQVRMLLDVRDSVENRHIMLVEDIVDSAITLQYLM 138
Query: 127 DSLKKSEPASIKTLVAIDKPGGRKIPFTAEYVVADVPNVFVVGYGLDYDQSYREVRDVVI 186
+ +PAS+KT+V +DKP GRK+ +Y V +P FV+GYG+D+ +SYRE+RD+ +
Sbjct: 139 RFMLAKKPASLKTVVLLDKPSGRKVDVLVDYPVITIPRAFVIGYGMDFAESYRELRDICV 198
Query: 187 LKPSVYE 193
LK YE
Sbjct: 199 LKKEYYE 205
>gi|91701622|gb|ABE47510.1| hypoxanthine-guanine phosphoribosyltransferase [Leishmania
infantum]
Length = 168
Score = 154 bits (388), Expect = 4e-36, Method: Composition-based stats.
Identities = 74/161 (45%), Positives = 116/161 (72%), Gaps = 1/161 (0%)
Query: 28 AQRIADDYSNCNLKPLENPLVVVSVLRGSFVFTADMVRILGDFGVPTRVEFLRASSYGHD 87
A++IA+DY + L +NPL ++ VL+GSF+FTAD+ R L D GVP +VEF+ ASSYG
Sbjct: 6 AKKIAEDYRSFKLTT-DNPLYLLCVLKGSFIFTADLARFLADEGVPVKVEFICASSYGTG 64
Query: 88 TKSCGRVDVKADGLCDIRGKHVLVLEDILDTALTLREVVDSLKKSEPASIKTLVAIDKPG 147
++ G+V + D + +H+L++EDI+D+A+TL+ ++ + +PAS+KT+V +DKP
Sbjct: 65 VETSGQVRMLLDVRDSVENRHILIVEDIVDSAITLQYLMRFMLAKKPASLKTVVLLDKPS 124
Query: 148 GRKIPFTAEYVVADVPNVFVVGYGLDYDQSYREVRDVVILK 188
GRK+ +Y V +P+ FV+GYG+DY +SYRE+RD+ +LK
Sbjct: 125 GRKVEVLVDYPVITIPHAFVIGYGMDYAESYRELRDICVLK 165
>gi|91701618|gb|ABE47508.1| hypoxanthine-guanine phosphoribosyltransferase [Leishmania sp.
IMT208]
Length = 168
Score = 153 bits (386), Expect = 8e-36, Method: Composition-based stats.
Identities = 74/161 (45%), Positives = 115/161 (71%), Gaps = 1/161 (0%)
Query: 28 AQRIADDYSNCNLKPLENPLVVVSVLRGSFVFTADMVRILGDFGVPTRVEFLRASSYGHD 87
A++IA+DY + L NPL ++ VL+GSF+FTAD+ R L D GVP +VEF+ ASSYG
Sbjct: 6 AKKIAEDYRSFKLTTX-NPLYLLCVLKGSFIFTADLARFLADEGVPVKVEFICASSYGTG 64
Query: 88 TKSCGRVDVKADGLCDIRGKHVLVLEDILDTALTLREVVDSLKKSEPASIKTLVAIDKPG 147
++ G+V + D + +H+L++EDI+D+A+TL+ ++ + +PAS+KT+V +DKP
Sbjct: 65 VETSGQVRMLLDVRDSVENRHILIVEDIVDSAITLQYLMRFMLAKKPASLKTVVLLDKPS 124
Query: 148 GRKIPFTAEYVVADVPNVFVVGYGLDYDQSYREVRDVVILK 188
GRK+ +Y V +P+ FV+GYG+DY +SYRE+RD+ +LK
Sbjct: 125 GRKVEVLVDYPVITIPHAFVIGYGMDYAESYRELRDICVLK 165
>gi|91701620|gb|ABE47509.1| hypoxanthine-guanine phosphoribosyltransferase [Leishmania major]
Length = 168
Score = 152 bits (385), Expect = 1e-35, Method: Composition-based stats.
Identities = 74/161 (45%), Positives = 115/161 (71%), Gaps = 1/161 (0%)
Query: 28 AQRIADDYSNCNLKPLENPLVVVSVLRGSFVFTADMVRILGDFGVPTRVEFLRASSYGHD 87
A++IA+DY + L NPL ++ VL+GSF+FTAD+ R L D GVP +VEF+ ASSYG
Sbjct: 6 AKKIAEDYRSFKLTT-GNPLYLLCVLKGSFIFTADLARFLADEGVPVKVEFICASSYGTG 64
Query: 88 TKSCGRVDVKADGLCDIRGKHVLVLEDILDTALTLREVVDSLKKSEPASIKTLVAIDKPG 147
++ G+V + D + +H+L++EDI+D+A+TL+ ++ + +PAS+KT+V +DKP
Sbjct: 65 VETSGQVRMLLDVRDSVENRHILIVEDIVDSAITLQYLMRFMLAKKPASLKTVVLLDKPS 124
Query: 148 GRKIPFTAEYVVADVPNVFVVGYGLDYDQSYREVRDVVILK 188
GRK+ +Y V +P+ FV+GYG+DY +SYRE+RD+ +LK
Sbjct: 125 GRKVEVLVDYPVITIPHAFVIGYGMDYAESYRELRDICVLK 165
>gi|71649338|ref|XP_813397.1| hypoxanthine-guanine phosphoribosyltransferase, putative
[Trypanosoma cruzi strain CL Brener]
gi|70878275|gb|EAN91546.1| hypoxanthine-guanine phosphoribosyltransferase, putative
[Trypanosoma cruzi]
Length = 231
Score = 148 bits (373), Expect = 3e-34, Method: Composition-based stats.
Identities = 78/196 (39%), Positives = 126/196 (64%), Gaps = 14/196 (7%)
Query: 7 YDFATSVLFTEAELHTRMRGVAQRIADDYSNCN---------LKPL--ENPLVVVSVLRG 55
Y A ++ TE+ + ++ VA++IAD Y + + P+ ENPL+++SVL+G
Sbjct: 27 YPMAEELVATESVIQRSIKAVAKQIADFYRPLSHRDTHGGGGVAPISDENPLIIISVLKG 86
Query: 56 SFVFTADMVRILGDFGVPTRVEFLRASSYGHDTKSCGRVDVKADG-LCDIRGKHVLVLED 114
S++FTADMVR LGD+G+P V+FLR +SY T S ++ + A+ +RGKHVL+LED
Sbjct: 87 SYIFTADMVRYLGDYGLPHVVDFLRVASY-RGTSSTNKMQLLAETQFKALRGKHVLILED 145
Query: 115 ILDTALTLREVVDSLKKS-EPASIKTLVAIDKPGGRKIPFTAEYVVADVPNVFVVGYGLD 173
I+D+ TLR ++D +++ +PA++K V DKPGGR++ ++V VPN +V+GYG +
Sbjct: 146 IVDSGKTLRYILDKVQREHQPATLKVCVLADKPGGRRVTMQPDFVCLTVPNKYVIGYGFE 205
Query: 174 YDQSYREVRDVVILKP 189
+ +R R + L+P
Sbjct: 206 VNDRFRCFRHIFTLRP 221
>gi|71656750|ref|XP_816917.1| hypoxanthine-guanine phosphoribosyltransferase, putative
[Trypanosoma cruzi strain CL Brener]
gi|70882077|gb|EAN95066.1| hypoxanthine-guanine phosphoribosyltransferase, putative
[Trypanosoma cruzi]
Length = 231
Score = 147 bits (372), Expect = 4e-34, Method: Composition-based stats.
Identities = 78/196 (39%), Positives = 126/196 (64%), Gaps = 14/196 (7%)
Query: 7 YDFATSVLFTEAELHTRMRGVAQRIADDYSNCN---------LKPL--ENPLVVVSVLRG 55
Y A ++ TE+ + ++ VA++IAD Y + + P+ ENPL+++SVL+G
Sbjct: 27 YPMAEELVATESVIQRSIKAVAKQIADFYRPLSHRDTHGGGGVAPISDENPLIIISVLKG 86
Query: 56 SFVFTADMVRILGDFGVPTRVEFLRASSYGHDTKSCGRVDVKADG-LCDIRGKHVLVLED 114
S++FTADMVR LGD+G+P V+FLR +SY T S ++ + A+ +RGKHVL+LED
Sbjct: 87 SYIFTADMVRYLGDYGLPHVVDFLRVASY-RGTSSTNKMKLLAETQFKALRGKHVLILED 145
Query: 115 ILDTALTLREVVDSLKKS-EPASIKTLVAIDKPGGRKIPFTAEYVVADVPNVFVVGYGLD 173
I+D+ TLR ++D +++ +PA++K V DKPGGR++ ++V VPN +V+GYG +
Sbjct: 146 IVDSGKTLRYILDKVQREHQPATLKVCVLADKPGGRRVTMQPDFVCLTVPNKYVIGYGFE 205
Query: 174 YDQSYREVRDVVILKP 189
+ +R R + L+P
Sbjct: 206 VNDRFRCFRHIFTLRP 221
>gi|154337144|ref|XP_001564805.1| xanthine phosphoribosyltransferase [Leishmania braziliensis
MHOM/BR/75/M2904]
gi|134061843|emb|CAM38880.1| xanthine phosphoribosyltransferase [Leishmania braziliensis]
Length = 240
Score = 145 bits (367), Expect = 1e-33, Method: Composition-based stats.
Identities = 81/208 (38%), Positives = 130/208 (62%), Gaps = 26/208 (12%)
Query: 6 KYDFATSVLFTEAELHTRMRGVAQRIADDYS-----NCNLKP----------------LE 44
+Y A+S++ TE + ++++ +AQ IA+DY +C L P +
Sbjct: 23 EYPMASSIIATEDVIQSKIKAMAQTIANDYKLLTHRDCRLPPNVATGMETVVSEAPISYD 82
Query: 45 NPLVVVSVLRGSFVFTADMVRILGDFGVPTRVEFLRASSYGHDTKSCGRVDVKADGLC-- 102
NPL++VSVL+GS++FTAD +R LGD G+P V+F+R +SY T+S GRV + + GL
Sbjct: 83 NPLIIVSVLKGSYIFTADFIRYLGDCGLPHVVDFVRLTSYNDGTRSTGRVAMLS-GLKFE 141
Query: 103 DIRGKHVLVLEDILDTALTLREVVDS-LKKSEPASIKTLVAIDK-PGGRKIPFTAEYVVA 160
++RGKHVL++ED+ D+ TL + S ++K +P SIKTLV ++K RK+ F EY
Sbjct: 142 NLRGKHVLIVEDVCDSGRTLHFLRTSIIEKYQPKSIKTLVMVNKEAAARKVDFEPEYACL 201
Query: 161 DVPNVFVVGYGLDYDQSYREVRDVVILK 188
PN +++GYG + + YR++R ++IL+
Sbjct: 202 SSPNKYIIGYGFEVNDRYRDLRHILILR 229
>gi|5759078|gb|AAD50967.1|AF170105_2 xanthine phosphoribosyltransferase XPRT [Leishmania donovani]
Length = 241
Score = 138 bits (348), Expect = 2e-31, Method: Composition-based stats.
Identities = 79/209 (37%), Positives = 126/209 (60%), Gaps = 27/209 (12%)
Query: 6 KYDFATSVLFTEAELHTRMRGVAQRIADDYS-----NCNLKP-----------------L 43
+Y A+ ++ TE + T ++ +A IA DY + L P
Sbjct: 23 EYPMASGIVATEDVIQTNIKAMAHTIAKDYKSLSHRDARLSPSTAETAEAAEAAEAPISY 82
Query: 44 ENPLVVVSVLRGSFVFTADMVRILGDFGVPTRVEFLRASSYGHDTKSCGRVDVKADGLC- 102
+NPL+++SVL+GS++FT+D +R LGD G+P V+F+R +SY TKS G++ + A GL
Sbjct: 83 DNPLIIISVLKGSYIFTSDFIRYLGDCGLPHVVDFVRLASYNSGTKSTGQISMLA-GLRF 141
Query: 103 -DIRGKHVLVLEDILDTALTLREVVDS-LKKSEPASIKTLVAIDKP-GGRKIPFTAEYVV 159
++RGKHVL++ED+ D+ TLR + D ++K +P SIKTLV ++K RK+ F EY
Sbjct: 142 ENLRGKHVLIVEDVCDSGRTLRFLRDYIMEKFQPKSIKTLVMVNKEQAARKVDFDPEYFC 201
Query: 160 ADVPNVFVVGYGLDYDQSYREVRDVVILK 188
PN ++VGYG + + YR++R ++IL+
Sbjct: 202 LAGPNKYIVGYGFEVNDRYRDLRHILILR 230
>gi|7381265|gb|AAF61462.1|AF139722_1 hypoxanthine-guanine phosphoribosyltransferase; HGPRT [Leishmania
tarentolae]
Length = 210
Score = 137 bits (344), Expect = 6e-31, Method: Composition-based stats.
Identities = 72/187 (38%), Positives = 117/187 (62%), Gaps = 2/187 (1%)
Query: 7 YDFATSVLFTEAELHTRMRGVAQRIADDYSNCNLKPLENPLVVVSVLRGSFVFTADMVRI 66
Y + L T+ ++ A++IA DY + +L +NPL ++ VL+GSF+FTAD+ R
Sbjct: 20 YPMSARTLVTQEQVWAATAKCAKKIAADYKDFHLTA-DNPLYLLCVLKGSFIFTADLARF 78
Query: 67 LGDFGVPTRVEFLRASSYGHDTKSCGRVDVKADGLCDIRGKHVLVLEDILDTALTLREVV 126
L D GVP +VEF+ ASSYG ++ G+V + D + +H++++EDI+D+A+TL+ ++
Sbjct: 79 LADEGVPVKVEFICASSYGSGVETSGQVRMLLDVRDSVENRHIMLVEDIVDSAITLQYLM 138
Query: 127 DSLKKSEPASIKTLVAIDKPGGRKIPFTAEYVVADVPNVFVVGYGLDYDQSYREVRDVVI 186
+ +PAS+KT+V +DKP GRK+ +Y V +P+ FV+GY + R V D+ +
Sbjct: 139 RFMLAKKPASLKTVVLLDKPSGRKVDVLVDYPVITIPHAFVIGYVWTF-ADLRGVPDICV 197
Query: 187 LKPSVYE 193
LK YE
Sbjct: 198 LKKEYYE 204