BLASTP 2.2.17 [Aug-26-2007]
Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Reference for composition-based statistics:
Schäffer, Alejandro A., L. Aravind, Thomas L. Madden,
Schaffer, Alejandro A., L. Aravind, Thomas L. Madden,
Sergei Shavirin, John L. Spouge, Yuri I. Wolf,
Eugene V. Koonin, and Stephen F. Altschul (2001),
"Improving the accuracy of PSI-BLAST protein database searches with
composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005.
Query= XP_825204__[Trypanosoma_brucei]
(437 letters)
Database: nr.pal
6,348,806 sequences; 2,166,943,470 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|72392799|ref|XP_847200.1| isocitrate dehydrogenase [NADP... 909 0.0
gi|71649278|ref|XP_813368.1| isocitrate dehydrogenase [NADP... 751 0.0
gi|94469637|gb|ABF20272.1| mitochondrial isocitrate dehydro... 705 0.0
gi|146079062|ref|XP_001463680.1| isocitrate dehydrogenase [... 700 0.0
gi|94469581|gb|ABF20244.1| mitochondrial isocitrate dehydro... 700 0.0
gi|157865307|ref|XP_001681361.1| isocitrate dehydrogenase [... 699 0.0
gi|94469635|gb|ABF20271.1| mitochondrial isocitrate dehydro... 693 0.0
gi|154333083|ref|XP_001562802.1| isocitrate dehydrogenase [... 687 0.0
gi|159481269|ref|XP_001698704.1| isocitrate dehydrogenase, ... 598 e-169
gi|27370516|ref|NP_766599.1| isocitrate dehydrogenase 2 (NA... 574 e-162
gi|28461205|ref|NP_786984.1| isocitrate dehydrogenase 2 (NA... 574 e-162
gi|27065480|pdb|1LWD|A Chain A, Crystal Structure Of Nadp-D... 573 e-162
gi|109891934|sp|Q04467|IDHP_BOVIN Isocitrate dehydrogenase ... 573 e-162
gi|158518416|sp|P54071|IDHP_MOUSE Isocitrate dehydrogenase ... 573 e-161
gi|462384|sp|P33198|IDHP_PIG Isocitrate dehydrogenase [NADP... 573 e-161
gi|71896205|ref|NP_001026770.1| hypothetical protein LOC431... 572 e-161
gi|126273797|ref|XP_001369305.1| PREDICTED: hypothetical pr... 572 e-161
gi|62079055|ref|NP_001014183.1| hypothetical protein LOC361... 571 e-161
gi|119622488|gb|EAX02083.1| isocitrate dehydrogenase 2 (NAD... 570 e-161
gi|114658864|ref|XP_001168316.1| PREDICTED: isocitrate dehy... 569 e-160
gi|114658862|ref|XP_510589.2| PREDICTED: isocitrate dehydro... 567 e-160
gi|109082346|ref|XP_001095686.1| PREDICTED: isocitrate dehy... 567 e-160
gi|73951496|ref|XP_536192.2| PREDICTED: similar to isocitra... 567 e-160
gi|28178832|ref|NP_002159.2| isocitrate dehydrogenase 2 (NA... 566 e-160
gi|872121|emb|CAA49208.1| isocitrate dehydrogenase (NADP+) ... 566 e-160
gi|52345502|ref|NP_001004799.1| MGC69505 protein [Xenopus t... 566 e-159
gi|93115142|gb|ABE98244.1| mitochondrial isocitrate dehydro... 565 e-159
gi|62897391|dbj|BAD96636.1| isocitrate dehydrogenase 2 (NAD... 565 e-159
gi|41054651|ref|NP_955858.1| isocitrate dehydrogenase 2 (NA... 565 e-159
gi|71659757|ref|XP_821599.1| isocitrate dehydrogenase, puta... 565 e-159
gi|144228251|gb|ABO93633.1| isocitrate dehydrogenase 2 [Tox... 564 e-159
gi|47217869|emb|CAG02362.1| unnamed protein product [Tetrao... 564 e-159
gi|1236984|gb|AAC52473.1| isocitrate dehydrogenase 561 e-158
gi|1589591|prf||2211361A isocitrate dehydrogenase 561 e-158
gi|47224185|emb|CAG13105.1| unnamed protein product [Tetrao... 561 e-158
gi|168052755|ref|XP_001778805.1| predicted protein [Physcom... 560 e-158
gi|149279565|ref|ZP_01885694.1| isocitrate dehydrogenase [P... 560 e-157
gi|42525054|ref|NP_970434.1| isocitrate dehydrogenase [Bdel... 560 e-157
gi|145481051|ref|XP_001426548.1| hypothetical protein GSPAT... 559 e-157
gi|148227256|ref|NP_001080321.1| hypothetical protein LOC38... 559 e-157
gi|6320137|ref|NP_010217.1| Mitochondrial NADP-specific iso... 559 e-157
gi|156543824|ref|XP_001608101.1| PREDICTED: similar to isoc... 559 e-157
gi|145542716|ref|XP_001457045.1| hypothetical protein GSPAT... 558 e-157
gi|17550822|ref|NP_509875.1| C34F6.8 [Caenorhabditis elegan... 558 e-157
gi|158296265|ref|XP_001688948.1| AGAP006660-PA [Anopheles g... 558 e-157
gi|168052303|ref|XP_001778590.1| predicted protein [Physcom... 557 e-157
gi|115438939|ref|NP_001043749.1| Os01g0654500 [Oryza sativa... 557 e-157
gi|3747089|gb|AAC64182.1| NADP-dependent isocitrate dehydro... 557 e-157
gi|15982950|gb|AAL11503.1|AF367443_1 NADP-dependent isocitr... 556 e-157
gi|83858780|ref|ZP_00952302.1| isocitrate dehydrogenase [Oc... 556 e-157
gi|157768436|ref|XP_001676039.1| Hypothetical protein CBG17... 556 e-156
gi|156386405|ref|XP_001633903.1| predicted protein [Nematos... 556 e-156
gi|37962884|gb|AAR05796.1| NADP+-isocitrate dehydrogenase [... 556 e-156
gi|50303483|ref|XP_451683.1| unnamed protein product [Kluyv... 555 e-156
gi|72088537|ref|XP_780121.1| PREDICTED: similar to cytosoli... 555 e-156
gi|31339162|dbj|BAC77065.1| NADP-specific isocitrate dehydr... 555 e-156
gi|74005281|ref|XP_860821.1| PREDICTED: similar to Isocitra... 555 e-156
gi|114658860|ref|XP_001168291.1| PREDICTED: isocitrate dehy... 555 e-156
gi|2497259|sp|Q40345|IDHP_MEDSA Isocitrate dehydrogenase [N... 555 e-156
gi|54303717|gb|AAV33246.1| isocitrate dehydrogenase [Toxopl... 555 e-156
gi|57164307|ref|NP_001009276.1| cytosolic NADP-isocitrate d... 554 e-156
gi|149755011|ref|XP_001505172.1| PREDICTED: similar to Isoc... 553 e-156
gi|6807655|emb|CAB66637.1| hypothetical protein [Homo sapie... 552 e-155
gi|145553437|ref|XP_001462393.1| hypothetical protein GSPAT... 552 e-155
gi|114658858|ref|XP_001168261.1| PREDICTED: isocitrate dehy... 551 e-155
gi|3021512|emb|CAA65503.1| isocitrate dehydrogenase (NADP+)... 551 e-155
gi|3021513|emb|CAA65504.1| isocitrate dehydrogenase (NADP+)... 551 e-155
gi|49168486|emb|CAG38738.1| IDH1 [Homo sapiens] 551 e-155
gi|28178825|ref|NP_005887.2| isocitrate dehydrogenase 1 (NA... 551 e-155
gi|74005285|ref|XP_850187.1| PREDICTED: similar to Isocitra... 551 e-155
gi|110764717|ref|XP_623673.2| PREDICTED: similar to Isocitr... 551 e-155
gi|149641842|ref|XP_001511049.1| PREDICTED: similar to cyto... 550 e-155
gi|158423489|ref|YP_001524781.1| NADP-dependent isocitrate ... 550 e-155
gi|62203298|gb|AAH93020.1| Isocitrate dehydrogenase 1 (NADP... 550 e-155
gi|22326811|ref|NP_196963.2| isocitrate dehydrogenase, puta... 550 e-155
gi|6647554|sp|O88844|IDHC_MOUSE Isocitrate dehydrogenase [N... 550 e-155
gi|149241012|pdb|2CMJ|A Chain A, Crystal Structure Of Mouse... 550 e-155
gi|145537055|ref|XP_001454244.1| hypothetical protein GSPAT... 550 e-154
gi|49065470|emb|CAG38553.1| IDH1 [Homo sapiens] 550 e-154
gi|115697799|ref|XP_001176537.1| PREDICTED: similar to Isoc... 549 e-154
gi|158291350|ref|XP_312860.4| AGAP003168-PA [Anopheles gamb... 549 e-154
gi|155966095|gb|ABU41004.1| isocitrate dehydrogenase 1 [Ans... 549 e-154
gi|114582991|ref|XP_001141655.1| PREDICTED: isocitrate dehy... 549 e-154
gi|75832090|ref|NP_851355.2| isocitrate dehydrogenase 1 (NA... 549 e-154
gi|150025915|ref|YP_001296741.1| isocitrate dehydrogenase [... 549 e-154
gi|47217126|emb|CAG02627.1| unnamed protein product [Tetrao... 548 e-154
gi|50286037|ref|XP_445447.1| unnamed protein product [Candi... 548 e-154
gi|82941453|dbj|BAE48792.1| NADP-isocitrate dehydrogenase [... 548 e-154
gi|118093509|ref|XP_421965.2| PREDICTED: similar to cytosol... 548 e-154
gi|91083633|ref|XP_970446.1| PREDICTED: similar to isocitra... 548 e-154
gi|3641398|gb|AAD02918.1| NADP-dependent isocitrate dehydro... 548 e-154
gi|109100767|ref|XP_001107627.1| PREDICTED: isocitrate dehy... 548 e-154
gi|146180442|ref|XP_001020930.2| dehydrogenase, isocitrate/... 548 e-154
gi|55729814|emb|CAH91635.1| hypothetical protein [Pongo pyg... 548 e-154
gi|116259420|sp|Q5R9C5|IDHC_PONPY Isocitrate dehydrogenase ... 547 e-154
gi|170034336|ref|XP_001845030.1| isocitrate dehydrogenase [... 547 e-154
gi|162417975|ref|NP_034627.3| isocitrate dehydrogenase 1 (N... 547 e-154
gi|91091256|ref|XP_968850.1| PREDICTED: similar to CG7176-P... 547 e-154
gi|126135008|ref|XP_001384028.1| Isocitrate dehydrogenase [... 547 e-154
gi|74005283|ref|XP_860853.1| PREDICTED: similar to Isocitra... 547 e-154
>gi|72392799|ref|XP_847200.1| isocitrate dehydrogenase [NADP], mitochondrial precursor, putative
[Trypanosoma brucei TREU927]
gi|62358502|gb|AAX78964.1| isocitrate dehydrogenase [NADP], mitochondrial precursor, putative
[Trypanosoma brucei]
gi|70803230|gb|AAZ13134.1| isocitrate dehydrogenase [NADP], mitochondrial precursor, putative
[Trypanosoma brucei]
Length = 437
Score = 909 bits (2348), Expect = 0.0, Method: Composition-based stats.
Identities = 437/437 (100%), Positives = 437/437 (100%)
Query: 1 MFRRVACAASSVNAGALTPRFVSTTRPSLGRIKVSGTVVDMDGDEMTRIIWALIKEKLIL 60
MFRRVACAASSVNAGALTPRFVSTTRPSLGRIKVSGTVVDMDGDEMTRIIWALIKEKLIL
Sbjct: 1 MFRRVACAASSVNAGALTPRFVSTTRPSLGRIKVSGTVVDMDGDEMTRIIWALIKEKLIL 60
Query: 61 PHVDVPIEYYDLSITSRDASNDKVTEQAAEAIQRHNVGIKCATITPDEARVKEFNLKKMW 120
PHVDVPIEYYDLSITSRDASNDKVTEQAAEAIQRHNVGIKCATITPDEARVKEFNLKKMW
Sbjct: 61 PHVDVPIEYYDLSITSRDASNDKVTEQAAEAIQRHNVGIKCATITPDEARVKEFNLKKMW 120
Query: 121 KSPNGTIRNILGGTVFREPIIVKNVPRVVPQWSEPIIVGRHAYGDQYKATESLFPPGRLE 180
KSPNGTIRNILGGTVFREPIIVKNVPRVVPQWSEPIIVGRHAYGDQYKATESLFPPGRLE
Sbjct: 121 KSPNGTIRNILGGTVFREPIIVKNVPRVVPQWSEPIIVGRHAYGDQYKATESLFPPGRLE 180
Query: 181 LVHTPANGGSPQVLEVFNFKGEGVGLAMYNTRESVEAFAESCFEYAIMRRYPLVLSTKNT 240
LVHTPANGGSPQVLEVFNFKGEGVGLAMYNTRESVEAFAESCFEYAIMRRYPLVLSTKNT
Sbjct: 181 LVHTPANGGSPQVLEVFNFKGEGVGLAMYNTRESVEAFAESCFEYAIMRRYPLVLSTKNT 240
Query: 241 ILKKYDGLFLETFQRMYDTKYREQFERLNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDG 300
ILKKYDGLFLETFQRMYDTKYREQFERLNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDG
Sbjct: 241 ILKKYDGLFLETFQRMYDTKYREQFERLNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDG 300
Query: 301 DVQSDIVAQGFGSLGLMTSVLLCPDGKTIESEAAHGTVTRHYREHQKGKETSTNSVASIF 360
DVQSDIVAQGFGSLGLMTSVLLCPDGKTIESEAAHGTVTRHYREHQKGKETSTNSVASIF
Sbjct: 301 DVQSDIVAQGFGSLGLMTSVLLCPDGKTIESEAAHGTVTRHYREHQKGKETSTNSVASIF 360
Query: 361 AWTRGLAHRGKLDGNAPLVEFASSLERATIKTIEGGHMTKDLALCVHGAAALQRSHYETT 420
AWTRGLAHRGKLDGNAPLVEFASSLERATIKTIEGGHMTKDLALCVHGAAALQRSHYETT
Sbjct: 361 AWTRGLAHRGKLDGNAPLVEFASSLERATIKTIEGGHMTKDLALCVHGAAALQRSHYETT 420
Query: 421 EVFIDSVAEELARSVKG 437
EVFIDSVAEELARSVKG
Sbjct: 421 EVFIDSVAEELARSVKG 437
>gi|71649278|ref|XP_813368.1| isocitrate dehydrogenase [NADP], mitochondrial precursor, putative
[Trypanosoma cruzi strain CL Brener]
gi|70878244|gb|EAN91517.1| isocitrate dehydrogenase [NADP], mitochondrial precursor, putative
[Trypanosoma cruzi]
Length = 433
Score = 751 bits (1940), Expect = 0.0, Method: Composition-based stats.
Identities = 356/434 (82%), Positives = 392/434 (90%), Gaps = 4/434 (0%)
Query: 1 MFRRVACAASSVNAGALTPRFVSTTRPSLGRIKVSGTVVDMDGDEMTRIIWALIKEKLIL 60
MFRRVAC A ++STTRP L RIKVSG VVDMDGDEMTRIIW+LIKEKLIL
Sbjct: 1 MFRRVACRVPFTAAAVC---YMSTTRPRLERIKVSGKVVDMDGDEMTRIIWSLIKEKLIL 57
Query: 61 PHVDVPIEYYDLSITSRDASNDKVTEQAAEAIQRHNVGIKCATITPDEARVKEFNLKKMW 120
P+VDVPIEYYDLSIT+RDA+NDKVTEQAAEAI RHNVGIKCATITPDEARVKEFNLKKMW
Sbjct: 58 PYVDVPIEYYDLSITNRDATNDKVTEQAAEAILRHNVGIKCATITPDEARVKEFNLKKMW 117
Query: 121 KSPNGTIRNILGGTVFREPIIVKNVPRVVPQWSEPIIVGRHAYGDQYKATESLFPPGRLE 180
KSPNGTIRNI+GGTVFREPII+KN+PRVVPQW EPIIVGRHA+GDQY AT+++FP GRLE
Sbjct: 118 KSPNGTIRNIVGGTVFREPIIIKNIPRVVPQWREPIIVGRHAFGDQYAATDAVFPAGRLE 177
Query: 181 LVHTPANGGSPQVLEVFNFKGEGVGLAMYNTRESVEAFAESCFEYAIMRRYPLVLSTKNT 240
LVHTP GGSPQVL+V+ FKGEGVGLAMYNT ES+EAFA SCFEYA++R++PLVLSTKNT
Sbjct: 178 LVHTPP-GGSPQVLDVYTFKGEGVGLAMYNTLESIEAFAVSCFEYALLRKFPLVLSTKNT 236
Query: 241 ILKKYDGLFLETFQRMYDTKYREQFERLNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDG 300
ILKKYDGLFLETFQR+YD KY++QFE+L LTY HRLIDDQVAQMIKGNGGFVWACKNYDG
Sbjct: 237 ILKKYDGLFLETFQRLYDNKYKDQFEQLKLTYTHRLIDDQVAQMIKGNGGFVWACKNYDG 296
Query: 301 DVQSDIVAQGFGSLGLMTSVLLCPDGKTIESEAAHGTVTRHYREHQKGKETSTNSVASIF 360
DVQSDIVAQGFGSLGLMTSVLL PDGKTIE+EAAHGTVTRHYRE+QKGKETSTNSVASIF
Sbjct: 297 DVQSDIVAQGFGSLGLMTSVLLRPDGKTIEAEAAHGTVTRHYREYQKGKETSTNSVASIF 356
Query: 361 AWTRGLAHRGKLDGNAPLVEFASSLERATIKTIEGGHMTKDLALCVHGAAALQRSHYETT 420
AWTRGL+HRGKLDGN L FA++LE A I+TIE G MTKDLA+C++G LQRSHYETT
Sbjct: 357 AWTRGLSHRGKLDGNPALTNFAAALELAVIRTIEAGRMTKDLAICIYGQEKLQRSHYETT 416
Query: 421 EVFIDSVAEELARS 434
F++SVA ELAR+
Sbjct: 417 HEFLESVAAELART 430
>gi|94469637|gb|ABF20272.1| mitochondrial isocitrate dehydrogenase [Leishmania tropica]
Length = 435
Score = 705 bits (1820), Expect = 0.0, Method: Composition-based stats.
Identities = 324/436 (74%), Positives = 385/436 (88%), Gaps = 4/436 (0%)
Query: 1 MFRRVACAASSVNAGALTPRFVSTTRPSLG-RIKVSGTVVDMDGDEMTRIIWALIKEKLI 59
MFR+V+ A++S +T R S+T L RIKV VVDMDGDEMTRIIW+ IKEKLI
Sbjct: 1 MFRQVSAASAS---SLVTARSFSSTNVYLDKRIKVKNEVVDMDGDEMTRIIWSFIKEKLI 57
Query: 60 LPHVDVPIEYYDLSITSRDASNDKVTEQAAEAIQRHNVGIKCATITPDEARVKEFNLKKM 119
LP+VDVPI Y+DLS+T+RDA+NDKVT +AAEAI++ NVGIKCATITPDEARVKEFNLKKM
Sbjct: 58 LPYVDVPINYFDLSVTNRDATNDKVTVEAAEAIKKCNVGIKCATITPDEARVKEFNLKKM 117
Query: 120 WKSPNGTIRNILGGTVFREPIIVKNVPRVVPQWSEPIIVGRHAYGDQYKATESLFPPGRL 179
WKSPNGTIRNILGGTVFREPIIV N+PR+VPQW PI+VGRHA+GDQYKAT+++ PG+L
Sbjct: 118 WKSPNGTIRNILGGTVFREPIIVSNIPRIVPQWHNPIVVGRHAFGDQYKATDAVLKPGKL 177
Query: 180 ELVHTPANGGSPQVLEVFNFKGEGVGLAMYNTRESVEAFAESCFEYAIMRRYPLVLSTKN 239
+LVHTPA+G +P L+V++FKG+GVGLAMYNT+ES+E FA+SCF+YA+MR+YPLVL+TKN
Sbjct: 178 QLVHTPADGSAPTTLDVYDFKGDGVGLAMYNTKESIEGFAKSCFQYALMRKYPLVLTTKN 237
Query: 240 TILKKYDGLFLETFQRMYDTKYREQFERLNLTYVHRLIDDQVAQMIKGNGGFVWACKNYD 299
TILKKYDG+FL+TFQRMYD +Y+ FE+ +TY HRLIDDQVAQMIKG GGFVWACKNYD
Sbjct: 238 TILKKYDGMFLQTFQRMYDEQYKADFEKAGITYNHRLIDDQVAQMIKGEGGFVWACKNYD 297
Query: 300 GDVQSDIVAQGFGSLGLMTSVLLCPDGKTIESEAAHGTVTRHYREHQKGKETSTNSVASI 359
GDVQSDIVAQGFGSLGLMTSVL+CPDGKTIE+EAAHGTVTRHYR+HQ+GKETSTNSVASI
Sbjct: 298 GDVQSDIVAQGFGSLGLMTSVLMCPDGKTIEAEAAHGTVTRHYRQHQQGKETSTNSVASI 357
Query: 360 FAWTRGLAHRGKLDGNAPLVEFASSLERATIKTIEGGHMTKDLALCVHGAAALQRSHYET 419
+AWTRGLAHRGKLDGN+ LV F+ +LER +K IE GHMTKDLALCV+G++ ++R HYET
Sbjct: 358 YAWTRGLAHRGKLDGNSDLVRFSETLERVVVKAIEDGHMTKDLALCVYGSSGVKREHYET 417
Query: 420 TEVFIDSVAEELARSV 435
TE F+DSV L +++
Sbjct: 418 TEQFLDSVDAALKKAM 433
>gi|146079062|ref|XP_001463680.1| isocitrate dehydrogenase [NADP], mitochondrial precursor, putative
[Leishmania infantum JPCM5]
gi|134067767|emb|CAM66047.1| isocitrate dehydrogenase [NADP], mitochondrial precursor, putative
[Leishmania infantum]
Length = 435
Score = 700 bits (1807), Expect = 0.0, Method: Composition-based stats.
Identities = 314/405 (77%), Positives = 369/405 (91%)
Query: 31 RIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQAAE 90
RIKV VVDMDGDEMTRIIW+ IKEKLILP+VDVPI Y+DLS+T+RDA+NDKVT +AAE
Sbjct: 29 RIKVKNEVVDMDGDEMTRIIWSFIKEKLILPYVDVPINYFDLSVTNRDATNDKVTVEAAE 88
Query: 91 AIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRVVP 150
AI++ NVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIV N+PR+VP
Sbjct: 89 AIKKCNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVSNIPRIVP 148
Query: 151 QWSEPIIVGRHAYGDQYKATESLFPPGRLELVHTPANGGSPQVLEVFNFKGEGVGLAMYN 210
QW PI+VGRHA+GDQYKAT+++ PG+L+LVHTPA+G +P L+V++FKGEGVGLAMYN
Sbjct: 149 QWHNPIVVGRHAFGDQYKATDAVLKPGKLQLVHTPADGSAPTTLDVYDFKGEGVGLAMYN 208
Query: 211 TRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFERLNL 270
T+ES+E FA+SCF+YA+MR+YPLVL+TKNTILKKYDG+FL+TFQRMYD +Y+ FE+ +
Sbjct: 209 TKESIEGFAKSCFQYALMRKYPLVLTTKNTILKKYDGMFLQTFQRMYDEQYKADFEKAGI 268
Query: 271 TYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDGKTIE 330
TY HRLIDDQVAQMIKG GGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVL+CPDGKTIE
Sbjct: 269 TYNHRLIDDQVAQMIKGEGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLMCPDGKTIE 328
Query: 331 SEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLERATI 390
+EAAHGTVTRHYR+HQ+GKETSTNSVASI+AWTRGLAHRGKLDGN+ LV+F+ +LER +
Sbjct: 329 AEAAHGTVTRHYRQHQQGKETSTNSVASIYAWTRGLAHRGKLDGNSDLVKFSETLERVVV 388
Query: 391 KTIEGGHMTKDLALCVHGAAALQRSHYETTEVFIDSVAEELARSV 435
K IE GHMTKDLALCV+G++ ++R HYETTE F+DSV L +++
Sbjct: 389 KAIEDGHMTKDLALCVYGSSGVKREHYETTEQFLDSVDAALKKAM 433
>gi|94469581|gb|ABF20244.1| mitochondrial isocitrate dehydrogenase [Leishmania infantum]
gi|94469583|gb|ABF20245.1| mitochondrial isocitrate dehydrogenase [Leishmania infantum]
gi|94469585|gb|ABF20246.1| mitochondrial isocitrate dehydrogenase [Leishmania infantum]
gi|94469587|gb|ABF20247.1| mitochondrial isocitrate dehydrogenase [Leishmania infantum]
gi|94469589|gb|ABF20248.1| mitochondrial isocitrate dehydrogenase [Leishmania infantum]
gi|94469591|gb|ABF20249.1| mitochondrial isocitrate dehydrogenase [Leishmania infantum]
gi|94469593|gb|ABF20250.1| mitochondrial isocitrate dehydrogenase [Leishmania infantum]
gi|94469595|gb|ABF20251.1| mitochondrial isocitrate dehydrogenase [Leishmania infantum]
gi|94469597|gb|ABF20252.1| mitochondrial isocitrate dehydrogenase [Leishmania donovani]
gi|94469599|gb|ABF20253.1| mitochondrial isocitrate dehydrogenase [Leishmania donovani]
gi|94469601|gb|ABF20254.1| mitochondrial isocitrate dehydrogenase [Leishmania donovani
archibaldi]
gi|94469603|gb|ABF20255.1| mitochondrial isocitrate dehydrogenase [Leishmania donovani]
gi|94469605|gb|ABF20256.1| mitochondrial isocitrate dehydrogenase [Leishmania donovani]
gi|94469607|gb|ABF20257.1| mitochondrial isocitrate dehydrogenase [Leishmania infantum]
gi|94469609|gb|ABF20258.1| mitochondrial isocitrate dehydrogenase [Leishmania infantum]
gi|94469611|gb|ABF20259.1| mitochondrial isocitrate dehydrogenase [Leishmania donovani]
gi|94469613|gb|ABF20260.1| mitochondrial isocitrate dehydrogenase [Leishmania donovani]
gi|94469615|gb|ABF20261.1| mitochondrial isocitrate dehydrogenase [Leishmania infantum]
gi|94469617|gb|ABF20262.1| mitochondrial isocitrate dehydrogenase [Leishmania infantum]
gi|94469619|gb|ABF20263.1| mitochondrial isocitrate dehydrogenase [Leishmania infantum]
gi|94469621|gb|ABF20264.1| mitochondrial isocitrate dehydrogenase [Leishmania infantum]
gi|94469623|gb|ABF20265.1| mitochondrial isocitrate dehydrogenase [Leishmania infantum]
gi|94469625|gb|ABF20266.1| mitochondrial isocitrate dehydrogenase [Leishmania infantum]
gi|94469627|gb|ABF20267.1| mitochondrial isocitrate dehydrogenase [Leishmania donovani
archibaldi]
gi|94469629|gb|ABF20268.1| mitochondrial isocitrate dehydrogenase [Leishmania donovani
archibaldi]
gi|94469631|gb|ABF20269.1| mitochondrial isocitrate dehydrogenase [Leishmania donovani]
gi|94469633|gb|ABF20270.1| mitochondrial isocitrate dehydrogenase [Leishmania infantum]
Length = 435
Score = 700 bits (1806), Expect = 0.0, Method: Composition-based stats.
Identities = 314/405 (77%), Positives = 369/405 (91%)
Query: 31 RIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQAAE 90
RIKV VVDMDGDEMTRIIW+ IKEKLILP+VDVPI Y+DLS+T+RDA+NDKVT +AAE
Sbjct: 29 RIKVKNEVVDMDGDEMTRIIWSFIKEKLILPYVDVPINYFDLSVTNRDATNDKVTVEAAE 88
Query: 91 AIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRVVP 150
AI++ NVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIV N+PR+VP
Sbjct: 89 AIKKCNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVSNIPRIVP 148
Query: 151 QWSEPIIVGRHAYGDQYKATESLFPPGRLELVHTPANGGSPQVLEVFNFKGEGVGLAMYN 210
QW PI+VGRHA+GDQYKAT+++ PG+L+LVHTPA+G +P L+V++FKGEGVGLAMYN
Sbjct: 149 QWHNPIVVGRHAFGDQYKATDAVLKPGKLQLVHTPADGSAPTTLDVYDFKGEGVGLAMYN 208
Query: 211 TRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFERLNL 270
T+ES+E FA+SCF+YA+MR+YPLVL+TKNTILKKYDG+FL+TFQRMYD +Y+ FE+ +
Sbjct: 209 TKESIEGFAKSCFQYALMRKYPLVLTTKNTILKKYDGMFLQTFQRMYDEQYKADFEKAGI 268
Query: 271 TYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDGKTIE 330
TY HRLIDDQVAQMIKG GGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVL+CPDGKTIE
Sbjct: 269 TYNHRLIDDQVAQMIKGEGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLMCPDGKTIE 328
Query: 331 SEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLERATI 390
+EAAHGTVTRHYR+HQ+GKETSTNSVASI+AWTRGLAHRGKLDGN+ LV+F+ +LER +
Sbjct: 329 AEAAHGTVTRHYRQHQQGKETSTNSVASIYAWTRGLAHRGKLDGNSDLVKFSETLERVVV 388
Query: 391 KTIEGGHMTKDLALCVHGAAALQRSHYETTEVFIDSVAEELARSV 435
K IE GHMTKDLALCV+G++ ++R HYETTE F+DSV L +++
Sbjct: 389 KAIEDGHMTKDLALCVYGSSGVKREHYETTEQFLDSVDAALKKAM 433
>gi|157865307|ref|XP_001681361.1| isocitrate dehydrogenase [NADP], mitochondrial precursor, putative
[Leishmania major]
gi|68124657|emb|CAJ02471.1| isocitrate dehydrogenase [NADP], mitochondrial precursor, putative
[Leishmania major]
Length = 435
Score = 699 bits (1804), Expect = 0.0, Method: Composition-based stats.
Identities = 313/405 (77%), Positives = 369/405 (91%)
Query: 31 RIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQAAE 90
RIKV VVDMDGDEMTRIIW+ IKEKLILP+VDVPI Y+DLS+T+RDA+NDKVT +AAE
Sbjct: 29 RIKVKNEVVDMDGDEMTRIIWSFIKEKLILPYVDVPINYFDLSVTNRDATNDKVTVEAAE 88
Query: 91 AIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRVVP 150
A+++ NVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIV N+PR+VP
Sbjct: 89 AVKKCNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVSNIPRIVP 148
Query: 151 QWSEPIIVGRHAYGDQYKATESLFPPGRLELVHTPANGGSPQVLEVFNFKGEGVGLAMYN 210
QW PI+VGRHA+GDQYKAT+++ PG+L+LVHTPA+G +P L+V++FKGEGVGLAMYN
Sbjct: 149 QWHNPIVVGRHAFGDQYKATDAVLKPGKLQLVHTPADGSAPTTLDVYDFKGEGVGLAMYN 208
Query: 211 TRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFERLNL 270
T+ES+E FA+SCF+YA+MR+YPLVL+TKNTILKKYDG+FL+TFQRMYD +Y+ FE+ +
Sbjct: 209 TKESIEGFAKSCFQYALMRKYPLVLTTKNTILKKYDGMFLQTFQRMYDEQYKADFEKAGI 268
Query: 271 TYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDGKTIE 330
TY HRLIDDQVAQMIKG GGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVL+CPDGKTIE
Sbjct: 269 TYNHRLIDDQVAQMIKGEGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLMCPDGKTIE 328
Query: 331 SEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLERATI 390
+EAAHGTVTRHYR+HQ+GKETSTNSVASI+AWTRGLAHRGKLDGN+ LV+F+ +LER +
Sbjct: 329 AEAAHGTVTRHYRQHQQGKETSTNSVASIYAWTRGLAHRGKLDGNSDLVKFSETLERVVV 388
Query: 391 KTIEGGHMTKDLALCVHGAAALQRSHYETTEVFIDSVAEELARSV 435
K IE GHMTKDLALCV+G++ ++R HYETTE F+DSV L +++
Sbjct: 389 KAIEDGHMTKDLALCVYGSSGVKREHYETTEQFLDSVDTALKKAM 433
>gi|94469635|gb|ABF20271.1| mitochondrial isocitrate dehydrogenase [Leishmania gerbilli]
Length = 435
Score = 693 bits (1788), Expect = 0.0, Method: Composition-based stats.
Identities = 312/405 (77%), Positives = 367/405 (90%)
Query: 31 RIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQAAE 90
RIKV VVDMDGDEMTRIIW+ IKEKLILP+VDVPI Y+DLS+T+RDA+NDKVT +AAE
Sbjct: 29 RIKVKNEVVDMDGDEMTRIIWSSIKEKLILPYVDVPINYFDLSVTNRDATNDKVTVEAAE 88
Query: 91 AIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRVVP 150
AI++ NVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIV N+PR+VP
Sbjct: 89 AIKKCNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVSNIPRIVP 148
Query: 151 QWSEPIIVGRHAYGDQYKATESLFPPGRLELVHTPANGGSPQVLEVFNFKGEGVGLAMYN 210
QW PI+VGRHA+GDQYKAT+++ PG+L+LVHTPA+G +P L+V++FKGEGVGLAMYN
Sbjct: 149 QWHNPIVVGRHAFGDQYKATDAVLKPGKLQLVHTPADGSAPTTLDVYDFKGEGVGLAMYN 208
Query: 211 TRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFERLNL 270
T+ES+E FA+SCF+YA+MR+YPLVL+TKNTILKKYDG+FL+TFQRMYD +Y+ FE+ +
Sbjct: 209 TKESIEGFAKSCFQYALMRKYPLVLTTKNTILKKYDGMFLQTFQRMYDEQYKADFEKAGI 268
Query: 271 TYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDGKTIE 330
TY HRLIDDQVAQMIKG GGFVWACKNY GD QSDIVAQGFGSLGLMTSVL+CPDGKTIE
Sbjct: 269 TYNHRLIDDQVAQMIKGEGGFVWACKNYGGDAQSDIVAQGFGSLGLMTSVLMCPDGKTIE 328
Query: 331 SEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLERATI 390
+EAAHGTVTRHYR+HQ+GKETSTNSVASI+AWTRGLAHRGKLDGN+ LV+F+ +LER +
Sbjct: 329 AEAAHGTVTRHYRQHQQGKETSTNSVASIYAWTRGLAHRGKLDGNSDLVKFSETLERVVV 388
Query: 391 KTIEGGHMTKDLALCVHGAAALQRSHYETTEVFIDSVAEELARSV 435
K IE GHMTKDLALCV+G++ ++R HYETTE F+DSV L +++
Sbjct: 389 KAIEDGHMTKDLALCVYGSSGVKREHYETTEQFLDSVDAALKKAM 433
>gi|154333083|ref|XP_001562802.1| isocitrate dehydrogenase [NADP], mitochondrial precursor, putative
[Leishmania braziliensis MHOM/BR/75/M2904]
gi|134059807|emb|CAM37233.1| isocitrate dehydrogenase [NADP], mitochondrial precursor, putative
[Leishmania braziliensis]
Length = 435
Score = 687 bits (1774), Expect = 0.0, Method: Composition-based stats.
Identities = 311/417 (74%), Positives = 369/417 (88%), Gaps = 1/417 (0%)
Query: 20 RFVSTTRPSLG-RIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRD 78
R S+T LG RIKV VVDMDGDEMTRIIW+LIKEKLILP+VDVPI Y+DLS+T RD
Sbjct: 17 RAFSSTNVCLGKRIKVKNEVVDMDGDEMTRIIWSLIKEKLILPYVDVPINYFDLSVTHRD 76
Query: 79 ASNDKVTEQAAEAIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFRE 138
A+NDKVT AAEAI + NVGIKCATITPDE+RV EFNLKKMWKSPNGTIRNILGGTVFRE
Sbjct: 77 ATNDKVTVDAAEAIMKCNVGIKCATITPDESRVTEFNLKKMWKSPNGTIRNILGGTVFRE 136
Query: 139 PIIVKNVPRVVPQWSEPIIVGRHAYGDQYKATESLFPPGRLELVHTPANGGSPQVLEVFN 198
PIIV N+PR+V W EPI+VGRHA+GDQYKAT++++ PG+L+LVHTPA+G +P L+V++
Sbjct: 137 PIIVSNIPRIVKHWKEPIVVGRHAFGDQYKATDTIYKPGKLQLVHTPADGSAPTTLDVYD 196
Query: 199 FKGEGVGLAMYNTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYD 258
FK EGVG+AMYNT++S+E FA+SCF+YA+MR+YPLVL+TKNTILKKYDG+FL+TFQRMY+
Sbjct: 197 FKSEGVGMAMYNTKKSIEGFAKSCFQYALMRKYPLVLTTKNTILKKYDGVFLQTFQRMYE 256
Query: 259 TKYREQFERLNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMT 318
+Y+ FE+ +TY HRLIDDQVAQMIKG GGFVWACKNYDGDVQSDIVAQGFGSLGLMT
Sbjct: 257 EQYKSDFEKAGITYNHRLIDDQVAQMIKGEGGFVWACKNYDGDVQSDIVAQGFGSLGLMT 316
Query: 319 SVLLCPDGKTIESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPL 378
SVL+CPDGKTIE+EAAHGTVTRHYR+HQ+GKETSTNS+ASI+AWTRGLAHRGKLDGN L
Sbjct: 317 SVLMCPDGKTIEAEAAHGTVTRHYRQHQQGKETSTNSIASIYAWTRGLAHRGKLDGNCDL 376
Query: 379 VEFASSLERATIKTIEGGHMTKDLALCVHGAAALQRSHYETTEVFIDSVAEELARSV 435
V+F+ LE+ IKT+E GHMTKDLALCVHG++ ++R YETTE F++SV L +++
Sbjct: 377 VKFSDMLEKVVIKTVEDGHMTKDLALCVHGSSGVKREQYETTEEFLNSVDAALKKAM 433
>gi|159481269|ref|XP_001698704.1| isocitrate dehydrogenase, NADP-dependent [Chlamydomonas
reinhardtii]
gi|158273598|gb|EDO99386.1| isocitrate dehydrogenase, NADP-dependent [Chlamydomonas
reinhardtii]
Length = 483
Score = 598 bits (1543), Expect = e-169, Method: Composition-based stats.
Identities = 275/414 (66%), Positives = 338/414 (81%), Gaps = 1/414 (0%)
Query: 25 TRPSLGRIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKV 84
T + G+I V+ VVD+DGDEMTR+IW IK+KLILP++D+ I Y+DL + +RD +NDKV
Sbjct: 68 TMATAGKIHVANPVVDLDGDEMTRVIWQQIKDKLILPYLDLKIVYFDLGLPNRDKTNDKV 127
Query: 85 TEQAAEAIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKN 144
TE+AA AI+ HNVGIKCATITPDEARVKEF LKKMWKSPNGTIRNIL GTVFREPI++ N
Sbjct: 128 TEEAAYAIKEHNVGIKCATITPDEARVKEFGLKKMWKSPNGTIRNILNGTVFREPIVISN 187
Query: 145 VPRVVPQWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNFKGEG 203
+PR+VP W++PI+VGRHA+GDQYKAT+ + PG+LE++ TPA GG+P+ EV++F+G G
Sbjct: 188 IPRLVPGWTKPIVVGRHAFGDQYKATDFVVDGPGKLEMIFTPAAGGAPRKFEVYSFEGPG 247
Query: 204 VGLAMYNTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYRE 263
V + MYNT ES+ FA SCFEYA+ +R+PL LSTKNTILK YDG FL+ F Y+T+Y++
Sbjct: 248 VAMGMYNTEESIRGFASSCFEYALQKRWPLYLSTKNTILKSYDGRFLQIFAETYETQYKK 307
Query: 264 QFERLNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLC 323
Q+E + Y HRLIDD VAQ +K +GGFVWACKNYDGDVQSDIVAQG+GSLGLMTSVL+
Sbjct: 308 QYEEAGIWYEHRLIDDMVAQGLKSSGGFVWACKNYDGDVQSDIVAQGYGSLGLMTSVLVT 367
Query: 324 PDGKTIESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFAS 383
PDGKT+E+EAAHGTVTRH+RE+QKGK TSTN VASIFAWTRGLAHRGKLD NA L+++
Sbjct: 368 PDGKTVEAEAAHGTVTRHWREYQKGKPTSTNPVASIFAWTRGLAHRGKLDNNAELIQWTH 427
Query: 384 SLERATIKTIEGGHMTKDLALCVHGAAALQRSHYETTEVFIDSVAEELARSVKG 437
LE A I+TIE GHMTKDLA+CVHG + Y TE F+D+VA+ A+ G
Sbjct: 428 DLEAAVIETIEQGHMTKDLAICVHGTTKVTPDQYLNTEPFMDAVADTFAKKRGG 481
>gi|27370516|ref|NP_766599.1| isocitrate dehydrogenase 2 (NADP+), mitochondrial [Mus musculus]
gi|12003362|gb|AAG43538.1|AF212319_1 NADP+-specific isocitrate dehydrogenase [Mus musculus]
Length = 452
Score = 574 bits (1480), Expect = e-162, Method: Composition-based stats.
Identities = 263/407 (64%), Positives = 326/407 (80%), Gaps = 2/407 (0%)
Query: 31 RIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQAAE 90
RIKV VV+MDGDEMTRIIW IKEKLILPHVDV ++Y+DL + +RD +ND+VT +A
Sbjct: 43 RIKVEKPVVEMDGDEMTRIIWQFIKEKLILPHVDVQLKYFDLGLPNRDQTNDQVTIDSAL 102
Query: 91 AIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRVVP 150
A Q+++V +KCATITPDEARV+EF LKKMWKSPNGTIRNILGGTVFREPII KN+PR+VP
Sbjct: 103 ATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVP 162
Query: 151 QWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNFKGEGVGLAMY 209
W++PI +GRHA+GDQYKAT+ + G +LV TP +G S + EV+NF GVG+ MY
Sbjct: 163 GWTKPITIGRHAHGDQYKATDFVVDRAGTFKLVFTPKDGSSAKEWEVYNFPAGGVGMGMY 222
Query: 210 NTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFERLN 269
NT ES+ FA SCF+Y+I +++PL LSTKNTILK YDG F + FQ ++D Y+ F+R
Sbjct: 223 NTDESISGFAHSCFQYSIQKKWPLYLSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDRNK 282
Query: 270 LTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDGKTI 329
+ Y HRLIDD VAQ++K +GGFVWACKNYDGDVQSDI+AQGFGSLGLMTSVL+CPDGKTI
Sbjct: 283 IWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTI 342
Query: 330 ESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLERAT 389
E+EAAHGTVTRHYREHQKG+ TSTN +ASIFAWTRGL HRGKLDGN L+ FA +LE+
Sbjct: 343 EAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQTLEKVC 402
Query: 390 IKTIEGGHMTKDLALCVHGAAALQ-RSHYETTEVFIDSVAEELARSV 435
++T+E G MTKDLA C+HG + ++ H+ T F+D++ L R++
Sbjct: 403 VQTVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRAL 449
>gi|28461205|ref|NP_786984.1| isocitrate dehydrogenase 2 (NADP+), mitochondrial [Bos taurus]
gi|430|emb|CAA49207.1| isocitrate dehydrogenase (NADP+) [Bos taurus]
Length = 452
Score = 574 bits (1480), Expect = e-162, Method: Composition-based stats.
Identities = 270/444 (60%), Positives = 341/444 (76%), Gaps = 15/444 (3%)
Query: 4 RVACAASSVNAGALTPRFVSTTRPSL----------GRIKVSGTVVDMDGDEMTRIIWAL 53
R C AS + A PR + T P+L RIKV+ VV+MDGDEMTRIIW
Sbjct: 9 RSLCRASG-SGSAWAPR--ALTAPNLQEQPRRHYADKRIKVAKPVVEMDGDEMTRIIWQF 65
Query: 54 IKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQAAEAIQRHNVGIKCATITPDEARVKE 113
IKEKLILPHVDV ++Y+DL + +RD +ND+VT +A A Q+++V +KCATITPDEARV+E
Sbjct: 66 IKEKLILPHVDVQLKYFDLGLPNRDQTNDQVTIDSALATQKYSVAVKCATITPDEARVEE 125
Query: 114 FNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRVVPQWSEPIIVGRHAYGDQYKATESL 173
F LKKMWKSPNGTIRNILGGTVFREPII KN+PR+VP W++PI +GRHA+GDQYKAT+ +
Sbjct: 126 FKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYKATDFV 185
Query: 174 FP-PGRLELVHTPANGGSPQVLEVFNFKGEGVGLAMYNTRESVEAFAESCFEYAIMRRYP 232
G ++V TP +G P+ EV+NF GVG+ MYNT ES+ FA SCF+YAI +++P
Sbjct: 186 VDRAGTFKVVFTPKDGSGPKEWEVYNFPAGGVGMGMYNTDESISGFAHSCFQYAIQKKWP 245
Query: 233 LVLSTKNTILKKYDGLFLETFQRMYDTKYREQFERLNLTYVHRLIDDQVAQMIKGNGGFV 292
L +STKNTILK YDG F + FQ +++ Y+ +F++ + Y HRLIDD VAQ++K +GGFV
Sbjct: 246 LYMSTKNTILKAYDGRFKDIFQAIFEKHYKTEFDKHKIWYEHRLIDDMVAQVLKSSGGFV 305
Query: 293 WACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDGKTIESEAAHGTVTRHYREHQKGKETS 352
WACKNYDGDVQSDI+AQGFGSLGLMTSVL+CPDGKTIE+EAAHGTVTRHYREHQKG+ TS
Sbjct: 306 WACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTS 365
Query: 353 TNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLERATIKTIEGGHMTKDLALCVHGAAAL 412
TN +ASIFAWTRGL HRGKLDGN L+ FA +LE+ ++T+E G MTKDLA C+HG + +
Sbjct: 366 TNPIASIFAWTRGLEHRGKLDGNQDLIRFAQTLEKVCVETVESGAMTKDLAGCIHGLSNV 425
Query: 413 Q-RSHYETTEVFIDSVAEELARSV 435
+ H+ T F+D++ L R++
Sbjct: 426 KLNEHFLNTSDFLDTIKSNLDRAL 449
>gi|27065480|pdb|1LWD|A Chain A, Crystal Structure Of Nadp-Dependent Isocitrate
Dehydrogenase From Porcine Heart Mitochondria
gi|27065481|pdb|1LWD|B Chain B, Crystal Structure Of Nadp-Dependent Isocitrate
Dehydrogenase From Porcine Heart Mitochondria
Length = 413
Score = 573 bits (1478), Expect = e-162, Method: Composition-based stats.
Identities = 260/407 (63%), Positives = 327/407 (80%), Gaps = 2/407 (0%)
Query: 31 RIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQAAE 90
RIKV+ VV+MDGDEMTRIIW IKEKLILPHVDV ++Y+DL + +RD +ND+VT +A
Sbjct: 4 RIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDVQLKYFDLGLPNRDQTNDQVTIDSAL 63
Query: 91 AIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRVVP 150
A Q+++V +KCATITPDEARV+EF LKKMWKSPNGTIRNILGGTVFREPII KN+PR+VP
Sbjct: 64 ATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVP 123
Query: 151 QWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNFKGEGVGLAMY 209
W++PI +GRHA+GDQYKAT+ + G ++V TP +G S + EV+NF GVG+ MY
Sbjct: 124 GWTKPITIGRHAHGDQYKATDFVVDRAGTFKIVFTPKDGSSAKQWEVYNFPAGGVGMGMY 183
Query: 210 NTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFERLN 269
NT ES+ FA SCF+YAI +++PL +STKNTILK YDG F + FQ +++ Y+ F++
Sbjct: 184 NTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFEKHYKTDFDKYK 243
Query: 270 LTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDGKTI 329
+ Y HRLIDD VAQ++K +GGFVWACKNYDGDVQSDI+AQGFGSLGLMTSVL+CPDGKTI
Sbjct: 244 IWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTI 303
Query: 330 ESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLERAT 389
E+EAAHGTVTRHYREHQKG+ TSTN +ASIFAWTRGL HRGKLDGN L+ FA +LE+
Sbjct: 304 EAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQTLEKVC 363
Query: 390 IKTIEGGHMTKDLALCVHGAAALQ-RSHYETTEVFIDSVAEELARSV 435
++T+E G MTKDLA C+HG + ++ H+ T F+D++ L R++
Sbjct: 364 VETVESGAMTKDLAGCIHGLSNVKLNEHFLNTSDFLDTIKSNLDRAL 410
>gi|109891934|sp|Q04467|IDHP_BOVIN Isocitrate dehydrogenase [NADP], mitochondrial precursor
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) (IDP) (ICD-M)
gi|73587323|gb|AAI02510.1| Isocitrate dehydrogenase 2 (NADP+), mitochondrial [Bos taurus]
Length = 452
Score = 573 bits (1477), Expect = e-162, Method: Composition-based stats.
Identities = 260/407 (63%), Positives = 328/407 (80%), Gaps = 2/407 (0%)
Query: 31 RIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQAAE 90
RIKV+ VV+MDGDEMTRIIW IKEKLILPHVDV ++Y+DL + +RD +ND+VT +A
Sbjct: 43 RIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDVQLKYFDLGLPNRDQTNDQVTIDSAL 102
Query: 91 AIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRVVP 150
A Q+++V +KCATITPDEARV+EF LKKMWKSPNGTIRNILGGTVFREPII KN+PR+VP
Sbjct: 103 ATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVP 162
Query: 151 QWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNFKGEGVGLAMY 209
W++PI +GRHA+GDQYKAT+ + G ++V TP +G P+ EV+NF GVG+ MY
Sbjct: 163 GWTKPITIGRHAHGDQYKATDFVVDRAGTFKVVFTPKDGSGPKEWEVYNFPAGGVGMGMY 222
Query: 210 NTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFERLN 269
NT ES+ FA SCF+YAI +++PL +STKNTILK YDG F + FQ +++ Y+ +F++
Sbjct: 223 NTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQAIFEKHYKTEFDKHK 282
Query: 270 LTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDGKTI 329
+ Y HRLIDD VAQ++K +GGFVWACKNYDGDVQSDI+AQGFGSLGLMTSVL+CPDGKTI
Sbjct: 283 IWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTI 342
Query: 330 ESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLERAT 389
E+EAAHGTVTRHYREHQKG+ TSTN +ASIFAWTRGL HRGKLDGN L+ FA +LE+
Sbjct: 343 EAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQTLEKVC 402
Query: 390 IKTIEGGHMTKDLALCVHGAAALQ-RSHYETTEVFIDSVAEELARSV 435
++T+E G MTKDLA C+HG + ++ H+ T F+D++ L R++
Sbjct: 403 VETVESGAMTKDLAGCIHGLSNVKLNEHFLNTSDFLDTIKSNLDRAL 449
>gi|158518416|sp|P54071|IDHP_MOUSE Isocitrate dehydrogenase [NADP], mitochondrial precursor
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) (IDP) (ICD-M)
gi|26353038|dbj|BAC40149.1| unnamed protein product [Mus musculus]
gi|37748684|gb|AAH60030.1| Isocitrate dehydrogenase 2 (NADP+), mitochondrial [Mus musculus]
gi|74151586|dbj|BAE41142.1| unnamed protein product [Mus musculus]
gi|74179881|dbj|BAE36505.1| unnamed protein product [Mus musculus]
gi|74217055|dbj|BAE26628.1| unnamed protein product [Mus musculus]
gi|148675088|gb|EDL07035.1| isocitrate dehydrogenase 2 (NADP+), mitochondrial, isoform CRA_d
[Mus musculus]
Length = 452
Score = 573 bits (1476), Expect = e-161, Method: Composition-based stats.
Identities = 262/407 (64%), Positives = 326/407 (80%), Gaps = 2/407 (0%)
Query: 31 RIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQAAE 90
RIKV VV+MDGDEMTRIIW IKEKLILPHVDV ++Y+DL + +RD +ND+VT +A
Sbjct: 43 RIKVEKPVVEMDGDEMTRIIWQFIKEKLILPHVDVQLKYFDLGLPNRDQTNDQVTIDSAL 102
Query: 91 AIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRVVP 150
A Q+++V +KCATITPDEARV+EF LKKMWKSPNGTIRNILGGTVFREPII KN+PR+VP
Sbjct: 103 ATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVP 162
Query: 151 QWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNFKGEGVGLAMY 209
W++PI +GRHA+GDQYKAT+ + G +LV TP +G S + EV+NF GVG+ MY
Sbjct: 163 GWTKPITIGRHAHGDQYKATDFVVDRAGTFKLVFTPKDGSSAKEWEVYNFPAGGVGMGMY 222
Query: 210 NTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFERLN 269
NT ES+ FA SCF+Y+I +++PL LSTKNTILK YDG F + FQ ++D Y+ F++
Sbjct: 223 NTDESISGFAHSCFQYSIQKKWPLYLSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNK 282
Query: 270 LTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDGKTI 329
+ Y HRLIDD VAQ++K +GGFVWACKNYDGDVQSDI+AQGFGSLGLMTSVL+CPDGKTI
Sbjct: 283 IWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTI 342
Query: 330 ESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLERAT 389
E+EAAHGTVTRHYREHQKG+ TSTN +ASIFAWTRGL HRGKLDGN L+ FA +LE+
Sbjct: 343 EAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQTLEKVC 402
Query: 390 IKTIEGGHMTKDLALCVHGAAALQ-RSHYETTEVFIDSVAEELARSV 435
++T+E G MTKDLA C+HG + ++ H+ T F+D++ L R++
Sbjct: 403 VQTVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRAL 449
>gi|462384|sp|P33198|IDHP_PIG Isocitrate dehydrogenase [NADP], mitochondrial precursor
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) (IDP) (ICD-M)
gi|294223|gb|AAA31089.1| NADPH-specific isocitrate dehydrogenase
Length = 421
Score = 573 bits (1476), Expect = e-161, Method: Composition-based stats.
Identities = 260/407 (63%), Positives = 327/407 (80%), Gaps = 2/407 (0%)
Query: 31 RIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQAAE 90
RIKV+ VV+MDGDEMTRIIW IKEKLILPHVDV ++Y+DL + +RD +ND+VT +A
Sbjct: 12 RIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDVQLKYFDLGLPNRDQTNDQVTIDSAL 71
Query: 91 AIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRVVP 150
A Q+++V +KCATITPDEARV+EF LKKMWKSPNGTIRNILGGTVFREPII KN+PR+VP
Sbjct: 72 ATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVP 131
Query: 151 QWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNFKGEGVGLAMY 209
W++PI +GRHA+GDQYKAT+ + G ++V TP +G S + EV+NF GVG+ MY
Sbjct: 132 GWTKPITIGRHAHGDQYKATDFVVDRAGTFKIVFTPKDGSSAKQWEVYNFPAGGVGMGMY 191
Query: 210 NTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFERLN 269
NT ES+ FA SCF+YAI +++PL +STKNTILK YDG F + FQ +++ Y+ F++
Sbjct: 192 NTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFEKHYKTDFDKYK 251
Query: 270 LTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDGKTI 329
+ Y HRLIDD VAQ++K +GGFVWACKNYDGDVQSDI+AQGFGSLGLMTSVL+CPDGKTI
Sbjct: 252 IWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTI 311
Query: 330 ESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLERAT 389
E+EAAHGTVTRHYREHQKG+ TSTN +ASIFAWTRGL HRGKLDGN L+ FA +LE+
Sbjct: 312 EAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQTLEKVC 371
Query: 390 IKTIEGGHMTKDLALCVHGAAALQ-RSHYETTEVFIDSVAEELARSV 435
++T+E G MTKDLA C+HG + ++ H+ T F+D++ L R++
Sbjct: 372 VETVESGAMTKDLAGCIHGLSNVKLNEHFLNTSDFLDTIKSNLDRAL 418
>gi|71896205|ref|NP_001026770.1| hypothetical protein LOC431056 [Gallus gallus]
gi|53130364|emb|CAG31511.1| hypothetical protein [Gallus gallus]
Length = 452
Score = 572 bits (1475), Expect = e-161, Method: Composition-based stats.
Identities = 260/407 (63%), Positives = 329/407 (80%), Gaps = 2/407 (0%)
Query: 31 RIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQAAE 90
RIKV+ VV+MDGDEMTRIIWA IKEKLILP+VDV ++Y+DL + RD ++D+VT +A
Sbjct: 43 RIKVANPVVEMDGDEMTRIIWAFIKEKLILPNVDVQLKYFDLGLPHRDKTDDQVTIDSAL 102
Query: 91 AIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRVVP 150
A ++++V +KCATITPDEARV+EF LKKMWKSPNGTIRNILGGTVFREPII KN+PR+VP
Sbjct: 103 ATKKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVP 162
Query: 151 QWSEPIIVGRHAYGDQYKATESLF-PPGRLELVHTPANGGSPQVLEVFNFKGEGVGLAMY 209
W++PI +GRHA+GDQYKAT+ + G ++V TP +G + EVFNF G GVG+ MY
Sbjct: 163 GWTQPITIGRHAHGDQYKATDFVVNKSGTFKMVFTPKDGSGVKEWEVFNFPGGGVGMGMY 222
Query: 210 NTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFERLN 269
NT ES+ FA SCF+YAI +++PL +STKNTILK YDG F + FQ ++D Y+ +F++L
Sbjct: 223 NTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTEFDKLK 282
Query: 270 LTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDGKTI 329
+ Y HRLIDD VAQ++K +GGFVWACKNYDGDVQSDI+AQGFGSLGLMTSVL+CPDGKTI
Sbjct: 283 IWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTI 342
Query: 330 ESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLERAT 389
E+EAAHGTVTRHYREHQKG+ TSTN +ASIFAWTRGL HRGKLD N L++FA +LE+
Sbjct: 343 EAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDSNPELIKFAQTLEKVC 402
Query: 390 IKTIEGGHMTKDLALCVHGAAALQ-RSHYETTEVFIDSVAEELARSV 435
++T+E G MTKDLA C+HG A ++ H+ T F+D++ L +++
Sbjct: 403 VETVESGTMTKDLAGCIHGLANVKLNEHFVNTTDFLDAIKNTLDKAL 449
>gi|126273797|ref|XP_001369305.1| PREDICTED: hypothetical protein [Monodelphis domestica]
Length = 455
Score = 572 bits (1473), Expect = e-161, Method: Composition-based stats.
Identities = 260/407 (63%), Positives = 324/407 (79%), Gaps = 2/407 (0%)
Query: 31 RIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQAAE 90
RIKV VV+MDGDEMTRIIW IKEKLILPHVDV ++Y+DL + RD ++D+VT +A
Sbjct: 46 RIKVDKPVVEMDGDEMTRIIWQFIKEKLILPHVDVQLKYFDLGLPHRDQTDDQVTIDSAL 105
Query: 91 AIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRVVP 150
A Q+++V +KCATITPDEARV+EF LKKMWKSPNGTIRNILGGTVFREPII KN+PR+VP
Sbjct: 106 ATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVP 165
Query: 151 QWSEPIIVGRHAYGDQYKATESLF-PPGRLELVHTPANGGSPQVLEVFNFKGEGVGLAMY 209
W+ PI +GRHA+GDQYKAT+ + G ++V TP +G + EV+NF GVG+ MY
Sbjct: 166 GWTRPITIGRHAHGDQYKATDFVVDKAGTFKMVFTPKDGSGAKEWEVYNFPAGGVGMGMY 225
Query: 210 NTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFERLN 269
NT ES+ FA SCF+YAI +++PL +STKNTILK YDG F + FQ ++D Y+ F++
Sbjct: 226 NTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNK 285
Query: 270 LTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDGKTI 329
+ Y HRLIDD VAQ++K NGGFVWACKNYDGDVQSDI+AQGFGSLGLMTSVL+CPDGKTI
Sbjct: 286 IWYEHRLIDDMVAQVLKSNGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTI 345
Query: 330 ESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLERAT 389
E+EAAHGTVTRHYREHQKG+ TSTN +ASIFAWTRGL HRGKLDGN L++FA +LE+
Sbjct: 346 EAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIKFAQTLEKVC 405
Query: 390 IKTIEGGHMTKDLALCVHGAAALQ-RSHYETTEVFIDSVAEELARSV 435
++T+E G MTKDLA C+HG + ++ HY T F+D++ L +++
Sbjct: 406 VQTVESGAMTKDLAGCIHGLSNVKLNEHYLNTGDFLDTIKNNLDKAL 452
>gi|62079055|ref|NP_001014183.1| hypothetical protein LOC361596 [Rattus norvegicus]
gi|119364595|sp|P56574|IDHP_RAT Isocitrate dehydrogenase [NADP], mitochondrial precursor
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) (IDP) (ICD-M)
gi|50370082|gb|AAH76398.1| Similar to NADP+-specific isocitrate dehydrogenase [Rattus
norvegicus]
gi|149057285|gb|EDM08608.1| similar to NADP+-specific isocitrate dehydrogenase, isoform CRA_b
[Rattus norvegicus]
Length = 452
Score = 571 bits (1471), Expect = e-161, Method: Composition-based stats.
Identities = 260/407 (63%), Positives = 325/407 (79%), Gaps = 2/407 (0%)
Query: 31 RIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQAAE 90
RIKV VV+MDGDEMTRIIW IKEKLILPHVDV ++Y+DL + +RD +ND+VT +A
Sbjct: 43 RIKVEKPVVEMDGDEMTRIIWQFIKEKLILPHVDVQLKYFDLGLPNRDQTNDQVTIDSAL 102
Query: 91 AIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRVVP 150
A Q+++V +KCATITPDEARV+EF LKKMWKSPNGTIRNILGGTVFREPII KN+PR+VP
Sbjct: 103 ATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVP 162
Query: 151 QWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNFKGEGVGLAMY 209
W++PI +GRHA+GDQYKAT+ + G +LV TP +G + EV+NF GVG+ MY
Sbjct: 163 GWTKPITIGRHAHGDQYKATDFVVDRAGMFKLVFTPKDGSGAKEWEVYNFPAGGVGMGMY 222
Query: 210 NTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFERLN 269
NT ES+ FA SCF+Y+I +++PL LSTKNTI+K YDG F + FQ ++D Y+ F++
Sbjct: 223 NTDESISGFAHSCFQYSIQKKWPLYLSTKNTIMKAYDGRFKDIFQEIFDKHYKTDFDKNK 282
Query: 270 LTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDGKTI 329
+ Y HRLIDD VAQ++K +GGFVWACKNYDGDVQSDI+AQGFGSLGLMTSVL+CPDGKTI
Sbjct: 283 IWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTI 342
Query: 330 ESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLERAT 389
E+EAAHGTVTRHYREHQKG+ TSTN +ASIFAWTRGL HRGKLDGN L+ FA +LE+
Sbjct: 343 EAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQTLEKVC 402
Query: 390 IKTIEGGHMTKDLALCVHGAAALQ-RSHYETTEVFIDSVAEELARSV 435
++T+E G MTKDLA C+HG + ++ H+ T F+D++ L R++
Sbjct: 403 VQTVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRAL 449
>gi|119622488|gb|EAX02083.1| isocitrate dehydrogenase 2 (NADP+), mitochondrial, isoform CRA_b
[Homo sapiens]
Length = 422
Score = 570 bits (1469), Expect = e-161, Method: Composition-based stats.
Identities = 261/418 (62%), Positives = 329/418 (78%), Gaps = 2/418 (0%)
Query: 20 RFVSTTRPSLGRIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDA 79
R VS + RIKV+ VV+MDGDEMTRIIW IKEKLILPHVD+ ++Y+DL + +RD
Sbjct: 2 RCVSLLLDADKRIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQ 61
Query: 80 SNDKVTEQAAEAIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREP 139
++D+VT +A A Q+++V +KCATITPDEARV+EF LKKMWKSPNGTIRNILGGTVFREP
Sbjct: 62 TDDQVTIDSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREP 121
Query: 140 IIVKNVPRVVPQWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFN 198
II KN+PR+VP W++PI +GRHA+GDQYKAT+ + G ++V TP +G + EV+N
Sbjct: 122 IICKNIPRLVPGWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYN 181
Query: 199 FKGEGVGLAMYNTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYD 258
F GVG+ MYNT ES+ FA SCF+YAI +++PL +STKNTILK YDG F + FQ ++D
Sbjct: 182 FPAGGVGMGMYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFD 241
Query: 259 TKYREQFERLNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMT 318
Y+ F++ + Y HRLIDD VAQ++K +GGFVWACKNYDGDVQSDI+AQGFGSLGLMT
Sbjct: 242 KHYKTDFDKNKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMT 301
Query: 319 SVLLCPDGKTIESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPL 378
SVL+CPDGKTIE+EAAHGTVTRHYREHQKG+ TSTN +ASIFAWTRGL HRGKLDGN L
Sbjct: 302 SVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDL 361
Query: 379 VEFASSLERATIKTIEGGHMTKDLALCVHGAAALQ-RSHYETTEVFIDSVAEELARSV 435
+ FA LE+ ++T+E G MTKDLA C+HG + ++ H+ T F+D++ L R++
Sbjct: 362 IRFAQMLEKVCVETVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRAL 419
>gi|114658864|ref|XP_001168316.1| PREDICTED: isocitrate dehydrogenase 2 (NADP+), mitochondrial
isoform 3 [Pan troglodytes]
Length = 415
Score = 569 bits (1466), Expect = e-160, Method: Composition-based stats.
Identities = 258/407 (63%), Positives = 326/407 (80%), Gaps = 2/407 (0%)
Query: 31 RIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQAAE 90
RIKV+ VV+MDGDEMTRIIW IKEKLILPHVD+ ++Y+DL + +RD ++D+VT +A
Sbjct: 6 RIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSAL 65
Query: 91 AIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRVVP 150
A Q+++V +KCATITPDEARV+EF LKKMWKSPNGTIRNILGGTVFREPII KN+PR+VP
Sbjct: 66 ATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVP 125
Query: 151 QWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNFKGEGVGLAMY 209
W++PI +GRHA+GDQYKAT+ + G ++V TP +G + EV+NF GVG+ MY
Sbjct: 126 GWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMY 185
Query: 210 NTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFERLN 269
NT ES+ FA SCF+YAI +++PL +STKNTILK YDG F + FQ ++D Y+ F++
Sbjct: 186 NTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNK 245
Query: 270 LTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDGKTI 329
+ Y HRLIDD VAQ++K +GGFVWACKNYDGDVQSDI+AQGFGSLGLMTSVL+CPDGKTI
Sbjct: 246 IWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTI 305
Query: 330 ESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLERAT 389
E+EAAHGTVTRHYREHQKG+ TSTN +ASIFAWTRGL HRGKLDGN L+ FA +LE+
Sbjct: 306 EAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQTLEKVC 365
Query: 390 IKTIEGGHMTKDLALCVHGAAALQ-RSHYETTEVFIDSVAEELARSV 435
++T+E G MTKDLA C+HG + ++ H+ T F+D++ L R++
Sbjct: 366 VETVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRAL 412
>gi|114658862|ref|XP_510589.2| PREDICTED: isocitrate dehydrogenase 2 (NADP+), mitochondrial
isoform 4 [Pan troglodytes]
Length = 452
Score = 567 bits (1462), Expect = e-160, Method: Composition-based stats.
Identities = 258/407 (63%), Positives = 326/407 (80%), Gaps = 2/407 (0%)
Query: 31 RIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQAAE 90
RIKV+ VV+MDGDEMTRIIW IKEKLILPHVD+ ++Y+DL + +RD ++D+VT +A
Sbjct: 43 RIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSAL 102
Query: 91 AIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRVVP 150
A Q+++V +KCATITPDEARV+EF LKKMWKSPNGTIRNILGGTVFREPII KN+PR+VP
Sbjct: 103 ATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVP 162
Query: 151 QWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNFKGEGVGLAMY 209
W++PI +GRHA+GDQYKAT+ + G ++V TP +G + EV+NF GVG+ MY
Sbjct: 163 GWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMY 222
Query: 210 NTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFERLN 269
NT ES+ FA SCF+YAI +++PL +STKNTILK YDG F + FQ ++D Y+ F++
Sbjct: 223 NTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNK 282
Query: 270 LTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDGKTI 329
+ Y HRLIDD VAQ++K +GGFVWACKNYDGDVQSDI+AQGFGSLGLMTSVL+CPDGKTI
Sbjct: 283 IWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTI 342
Query: 330 ESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLERAT 389
E+EAAHGTVTRHYREHQKG+ TSTN +ASIFAWTRGL HRGKLDGN L+ FA +LE+
Sbjct: 343 EAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQTLEKVC 402
Query: 390 IKTIEGGHMTKDLALCVHGAAALQ-RSHYETTEVFIDSVAEELARSV 435
++T+E G MTKDLA C+HG + ++ H+ T F+D++ L R++
Sbjct: 403 VETVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRAL 449
>gi|109082346|ref|XP_001095686.1| PREDICTED: isocitrate dehydrogenase 2 (NADP+), mitochondrial
[Macaca mulatta]
gi|75075872|sp|Q4R502|IDHP_MACFA Isocitrate dehydrogenase [NADP], mitochondrial precursor
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) (IDP) (ICD-M)
gi|67970962|dbj|BAE01823.1| unnamed protein product [Macaca fascicularis]
Length = 452
Score = 567 bits (1462), Expect = e-160, Method: Composition-based stats.
Identities = 258/407 (63%), Positives = 326/407 (80%), Gaps = 2/407 (0%)
Query: 31 RIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQAAE 90
RIKV+ VV+MDGDEMTRIIW IKEKLILPHVD+ ++Y+DL + +RD ++D+VT +A
Sbjct: 43 RIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSAL 102
Query: 91 AIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRVVP 150
A Q+++V +KCATITPDEARV+EF LKKMWKSPNGTIRNILGGTVFREPII KN+PR+VP
Sbjct: 103 ATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVP 162
Query: 151 QWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNFKGEGVGLAMY 209
W++PI +GRHA+GDQYKAT+ + G ++V TP +G + EV+NF GVG+ MY
Sbjct: 163 GWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMY 222
Query: 210 NTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFERLN 269
NT ES+ FA SCF+YAI +++PL +STKNTILK YDG F + FQ ++D Y+ F++
Sbjct: 223 NTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNK 282
Query: 270 LTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDGKTI 329
+ Y HRLIDD VAQ++K +GGFVWACKNYDGDVQSDI+AQGFGSLGLMTSVL+CPDGKTI
Sbjct: 283 IWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTI 342
Query: 330 ESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLERAT 389
E+EAAHGTVTRHYREHQKG+ TSTN +ASIFAWTRGL HRGKLDGN L+ FA +LE+
Sbjct: 343 EAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQTLEKVC 402
Query: 390 IKTIEGGHMTKDLALCVHGAAALQ-RSHYETTEVFIDSVAEELARSV 435
++T+E G MTKDLA C+HG + ++ H+ T F+D++ L R++
Sbjct: 403 VETVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRAL 449
>gi|73951496|ref|XP_536192.2| PREDICTED: similar to isocitrate dehydrogenase 2 (NADP+),
mitochondrial [Canis familiaris]
Length = 517
Score = 567 bits (1461), Expect = e-160, Method: Composition-based stats.
Identities = 257/407 (63%), Positives = 327/407 (80%), Gaps = 2/407 (0%)
Query: 31 RIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQAAE 90
RIKV+ VV+MDGDEMTRIIW IKEKLILPHVDV ++Y+DL + +RD +ND+VT +A
Sbjct: 109 RIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDVQLKYFDLGLPNRDQTNDQVTIDSAL 168
Query: 91 AIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRVVP 150
A Q+++V +KCATITPDEARV+EF LKKMWKSPNGTIRNILGGTVFREPII KN+PR+VP
Sbjct: 169 ATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVP 228
Query: 151 QWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNFKGEGVGLAMY 209
W++PI +GRHA+GDQYKAT+ + G +++ +P +G + EV+NF G GVG+ MY
Sbjct: 229 GWTKPITIGRHAHGDQYKATDFVVDRAGTFKIIFSPKDGSGAKEWEVYNFPGGGVGMGMY 288
Query: 210 NTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFERLN 269
NT ES+ FA SCF+YAI +++PL +STKNTILK YDG F + FQ +++ Y+ F++
Sbjct: 289 NTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFEKHYKTDFDKNK 348
Query: 270 LTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDGKTI 329
+ Y HRLIDD VAQ++K +GGFVWACKNYDGDVQSDI+AQGFGSLGLMTSVL+CPDGKTI
Sbjct: 349 IWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTI 408
Query: 330 ESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLERAT 389
E+EAAHGTVTRHYREHQKG+ TSTN +ASIFAWTRGL HRGKLDGN L+ FA +LE+
Sbjct: 409 EAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQTLEKVC 468
Query: 390 IKTIEGGHMTKDLALCVHGAAALQ-RSHYETTEVFIDSVAEELARSV 435
++T+E G MTKDLA C+HG + ++ H+ T F+D++ L +++
Sbjct: 469 VQTVESGAMTKDLAGCIHGLSNVKLNEHFLNTSDFLDTIKNNLDKAL 515
>gi|28178832|ref|NP_002159.2| isocitrate dehydrogenase 2 (NADP+), mitochondrial precursor [Homo
sapiens]
gi|20141568|sp|P48735|IDHP_HUMAN Isocitrate dehydrogenase [NADP], mitochondrial precursor
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) (IDP) (ICD-M)
gi|14328062|gb|AAH09244.1| Isocitrate dehydrogenase 2 (NADP+), mitochondrial [Homo sapiens]
gi|47938312|gb|AAH71828.1| Isocitrate dehydrogenase 2 (NADP+), mitochondrial [Homo sapiens]
gi|119622487|gb|EAX02082.1| isocitrate dehydrogenase 2 (NADP+), mitochondrial, isoform CRA_a
[Homo sapiens]
gi|123985895|gb|ABM83743.1| isocitrate dehydrogenase 2 (NADP+), mitochondrial [synthetic
construct]
gi|123998944|gb|ABM87062.1| isocitrate dehydrogenase 2 (NADP+), mitochondrial [synthetic
construct]
Length = 452
Score = 567 bits (1460), Expect = e-160, Method: Composition-based stats.
Identities = 258/407 (63%), Positives = 325/407 (79%), Gaps = 2/407 (0%)
Query: 31 RIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQAAE 90
RIKV+ VV+MDGDEMTRIIW IKEKLILPHVD+ ++Y+DL + +RD ++D+VT +A
Sbjct: 43 RIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSAL 102
Query: 91 AIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRVVP 150
A Q+++V +KCATITPDEARV+EF LKKMWKSPNGTIRNILGGTVFREPII KN+PR+VP
Sbjct: 103 ATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVP 162
Query: 151 QWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNFKGEGVGLAMY 209
W++PI +GRHA+GDQYKAT+ + G ++V TP +G + EV+NF GVG+ MY
Sbjct: 163 GWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMY 222
Query: 210 NTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFERLN 269
NT ES+ FA SCF+YAI +++PL +STKNTILK YDG F + FQ ++D Y+ F++
Sbjct: 223 NTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNK 282
Query: 270 LTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDGKTI 329
+ Y HRLIDD VAQ++K +GGFVWACKNYDGDVQSDI+AQGFGSLGLMTSVL+CPDGKTI
Sbjct: 283 IWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTI 342
Query: 330 ESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLERAT 389
E+EAAHGTVTRHYREHQKG+ TSTN +ASIFAWTRGL HRGKLDGN L+ FA LE+
Sbjct: 343 EAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQMLEKVC 402
Query: 390 IKTIEGGHMTKDLALCVHGAAALQ-RSHYETTEVFIDSVAEELARSV 435
++T+E G MTKDLA C+HG + ++ H+ T F+D++ L R++
Sbjct: 403 VETVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRAL 449
>gi|872121|emb|CAA49208.1| isocitrate dehydrogenase (NADP+) [Homo sapiens]
Length = 452
Score = 567 bits (1460), Expect = e-160, Method: Composition-based stats.
Identities = 258/407 (63%), Positives = 325/407 (79%), Gaps = 2/407 (0%)
Query: 31 RIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQAAE 90
RIKV+ VV+MDGDEMTRIIW IKEKLILPHVD+ ++Y+DL + +RD ++D+VT +A
Sbjct: 43 RIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSAL 102
Query: 91 AIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRVVP 150
A Q+++V +KCATITPDEARV+EF LKKMWKSPNGTIRNILGGTVFREPII KN+PR+VP
Sbjct: 103 ATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVP 162
Query: 151 QWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNFKGEGVGLAMY 209
W++PI +GRHA+GDQYKAT+ + G ++V TP +G + EV+NF GVG+ MY
Sbjct: 163 GWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMY 222
Query: 210 NTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFERLN 269
NT ES+ FA SCF+YAI +++PL +STKNTILK YDG F + FQ ++D Y+ F++
Sbjct: 223 NTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNK 282
Query: 270 LTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDGKTI 329
+ Y HRLIDD VAQ++K +GGFVWACKNYDGDVQSDI+AQGFGSLGLMTSVL+CPDGKTI
Sbjct: 283 IWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTI 342
Query: 330 ESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLERAT 389
E+EAAHGTVTRHYREHQKG+ TSTN +ASIFAWTRGL HRGKLDGN L+ FA LE+
Sbjct: 343 EAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQMLEKVC 402
Query: 390 IKTIEGGHMTKDLALCVHGAAALQ-RSHYETTEVFIDSVAEELARSV 435
++T+E G MTKDLA C+HG + ++ H+ T F+D++ L R++
Sbjct: 403 VETVESGAMTKDLAGCIHGLSNVKLNEHFLNTMDFLDTIKSNLDRAL 449