BLASTP 2.2.17 [Aug-26-2007]
Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Reference for composition-based statistics:
Schäffer, Alejandro A., L. Aravind, Thomas L. Madden,
Schaffer, Alejandro A., L. Aravind, Thomas L. Madden,
Sergei Shavirin, John L. Spouge, Yuri I. Wolf,
Eugene V. Koonin, and Stephen F. Altschul (2001),
"Improving the accuracy of PSI-BLAST protein database searches with
composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005.
Query= XP_828183__[Trypanosoma_brucei]
(413 letters)
Database: nr.pal
6,348,806 sequences; 2,166,943,470 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|71754537|ref|XP_828183.1| isocitrate dehydrogenase [Tryp... 858 0.0
gi|71659757|ref|XP_821599.1| isocitrate dehydrogenase, puta... 681 0.0
gi|157109449|ref|XP_001650675.1| nadp-specific isocitrate d... 593 e-168
gi|159481269|ref|XP_001698704.1| isocitrate dehydrogenase, ... 590 e-167
gi|170028051|ref|XP_001841910.1| isocitrate dehydrogenase c... 589 e-166
gi|158296265|ref|XP_001688948.1| AGAP006660-PA [Anopheles g... 586 e-165
gi|118093509|ref|XP_421965.2| PREDICTED: similar to cytosol... 585 e-165
gi|155966095|gb|ABU41004.1| isocitrate dehydrogenase 1 [Ans... 585 e-165
gi|49168486|emb|CAG38738.1| IDH1 [Homo sapiens] 584 e-165
gi|57164307|ref|NP_001009276.1| cytosolic NADP-isocitrate d... 583 e-165
gi|74005281|ref|XP_860821.1| PREDICTED: similar to Isocitra... 583 e-165
gi|149641842|ref|XP_001511049.1| PREDICTED: similar to cyto... 583 e-165
gi|109100767|ref|XP_001107627.1| PREDICTED: isocitrate dehy... 583 e-164
gi|28178825|ref|NP_005887.2| isocitrate dehydrogenase 1 (NA... 582 e-164
gi|75832090|ref|NP_851355.2| isocitrate dehydrogenase 1 (NA... 582 e-164
gi|62203298|gb|AAH93020.1| Isocitrate dehydrogenase 1 (NADP... 582 e-164
gi|31873324|emb|CAD97653.1| hypothetical protein [Homo sapi... 581 e-164
gi|149755011|ref|XP_001505172.1| PREDICTED: similar to Isoc... 581 e-164
gi|148232240|ref|NP_001088022.1| hypothetical protein LOC49... 581 e-164
gi|75056526|sp|Q9XSG3|IDHC_BOVIN Isocitrate dehydrogenase [... 580 e-164
gi|74005285|ref|XP_850187.1| PREDICTED: similar to Isocitra... 580 e-164
gi|41393155|ref|NP_958907.1| isocitrate dehydrogenase 1 (NA... 580 e-164
gi|114582991|ref|XP_001141655.1| PREDICTED: isocitrate dehy... 579 e-163
gi|169158156|emb|CAQ15240.1| isocitrate dehydrogenase 1 (NA... 579 e-163
gi|115697799|ref|XP_001176537.1| PREDICTED: similar to Isoc... 579 e-163
gi|116259420|sp|Q5R9C5|IDHC_PONPY Isocitrate dehydrogenase ... 578 e-163
gi|55725879|emb|CAH89719.1| hypothetical protein [Pongo pyg... 578 e-163
gi|6807655|emb|CAB66637.1| hypothetical protein [Homo sapie... 578 e-163
gi|47217126|emb|CAG02627.1| unnamed protein product [Tetrao... 578 e-163
gi|13928690|ref|NP_113698.1| isocitrate dehydrogenase 1 (NA... 578 e-163
gi|6647554|sp|O88844|IDHC_MOUSE Isocitrate dehydrogenase [N... 578 e-163
gi|6647567|sp|Q9Z2K9|IDHC_MICME Isocitrate dehydrogenase [N... 577 e-163
gi|3641398|gb|AAD02918.1| NADP-dependent isocitrate dehydro... 577 e-163
gi|149241012|pdb|2CMJ|A Chain A, Crystal Structure Of Mouse... 577 e-163
gi|162417975|ref|NP_034627.3| isocitrate dehydrogenase 1 (N... 577 e-163
gi|74195675|dbj|BAE39644.1| unnamed protein product [Mus mu... 577 e-163
gi|156386405|ref|XP_001633903.1| predicted protein [Nematos... 576 e-163
gi|49065470|emb|CAG38553.1| IDH1 [Homo sapiens] 576 e-163
gi|26352311|dbj|BAC39792.1| unnamed protein product [Mus mu... 576 e-162
gi|57242927|gb|AAH88986.1| Isocitrate dehydrogenase 1 (NADP... 576 e-162
gi|6647566|sp|Q9Z2K8|IDHC_MICOH Isocitrate dehydrogenase [N... 576 e-162
gi|72088537|ref|XP_780121.1| PREDICTED: similar to cytosoli... 575 e-162
gi|74005283|ref|XP_860853.1| PREDICTED: similar to Isocitra... 575 e-162
gi|55729814|emb|CAH91635.1| hypothetical protein [Pongo pyg... 574 e-162
gi|54303717|gb|AAV33246.1| isocitrate dehydrogenase [Toxopl... 573 e-161
gi|126337907|ref|XP_001365492.1| PREDICTED: similar to cyto... 572 e-161
gi|117927597|ref|YP_872148.1| isocitrate dehydrogenase [Aci... 571 e-161
gi|91091256|ref|XP_968850.1| PREDICTED: similar to CG7176-P... 570 e-161
gi|144228251|gb|ABO93633.1| isocitrate dehydrogenase 2 [Tox... 570 e-161
gi|114051866|ref|NP_001040134.1| isocitrate dehydrogenase [... 570 e-161
gi|50955486|ref|YP_062774.1| isocitrate dehydrogenase [Leif... 569 e-160
gi|42525054|ref|NP_970434.1| isocitrate dehydrogenase [Bdel... 568 e-160
gi|31339162|dbj|BAC77065.1| NADP-specific isocitrate dehydr... 568 e-160
gi|114152704|gb|ABI52605.1| isocitrate dehydrogenase [Gryll... 566 e-160
gi|2497259|sp|Q40345|IDHP_MEDSA Isocitrate dehydrogenase [N... 566 e-160
gi|15610475|ref|NP_217856.1| isocitrate dehydrogenase [Myco... 566 e-159
gi|109891934|sp|Q04467|IDHP_BOVIN Isocitrate dehydrogenase ... 566 e-159
gi|28461205|ref|NP_786984.1| isocitrate dehydrogenase 2 (NA... 566 e-159
gi|124599478|gb|EAY58582.1| isocitrate dehydrogenase [NADP]... 566 e-159
gi|170781034|ref|YP_001709366.1| isocitrate dehydrogenase [... 566 e-159
gi|148273721|ref|YP_001223282.1| isocitrate dehydrogenase [... 566 e-159
gi|73951496|ref|XP_536192.2| PREDICTED: similar to isocitra... 566 e-159
gi|940877|emb|CAA53300.1| isocitrate dehydrogenase (NADP+) ... 565 e-159
gi|71896205|ref|NP_001026770.1| hypothetical protein LOC431... 565 e-159
gi|146180442|ref|XP_001020930.2| dehydrogenase, isocitrate/... 565 e-159
gi|121639267|ref|YP_979491.1| isocitrate dehydrogenase [Myc... 565 e-159
gi|158518416|sp|P54071|IDHP_MOUSE Isocitrate dehydrogenase ... 565 e-159
gi|168052755|ref|XP_001778805.1| predicted protein [Physcom... 565 e-159
gi|27370516|ref|NP_766599.1| isocitrate dehydrogenase 2 (NA... 565 e-159
gi|126273797|ref|XP_001369305.1| PREDICTED: hypothetical pr... 565 e-159
gi|62897391|dbj|BAD96636.1| isocitrate dehydrogenase 2 (NAD... 564 e-159
gi|44921641|gb|AAS49171.1| NADP-dependent isocitrate dehydr... 564 e-159
gi|27065480|pdb|1LWD|A Chain A, Crystal Structure Of Nadp-D... 564 e-159
gi|462384|sp|P33198|IDHP_PIG Isocitrate dehydrogenase [NADP... 563 e-159
gi|93115142|gb|ABE98244.1| mitochondrial isocitrate dehydro... 563 e-159
gi|15221788|ref|NP_175836.1| ICDH (ICDH); isocitrate dehydr... 563 e-159
gi|3747089|gb|AAC64182.1| NADP-dependent isocitrate dehydro... 563 e-158
gi|28178832|ref|NP_002159.2| isocitrate dehydrogenase 2 (NA... 562 e-158
gi|1708400|sp|P50217|IDHC_SOLTU Isocitrate dehydrogenase [N... 562 e-158
gi|119622488|gb|EAX02083.1| isocitrate dehydrogenase 2 (NAD... 562 e-158
gi|114658862|ref|XP_510589.2| PREDICTED: isocitrate dehydro... 562 e-158
gi|872121|emb|CAA49208.1| isocitrate dehydrogenase (NADP+) ... 562 e-158
gi|83591696|ref|YP_425448.1| isocitrate dehydrogenase [Rhod... 561 e-158
gi|3811009|dbj|BAA34113.1| NADP specific isocitrate dehydro... 561 e-158
gi|109082346|ref|XP_001095686.1| PREDICTED: isocitrate dehy... 561 e-158
gi|62079055|ref|NP_001014183.1| hypothetical protein LOC361... 561 e-158
gi|157755515|ref|XP_001670101.1| Hypothetical protein CBG21... 561 e-158
gi|22326811|ref|NP_196963.2| isocitrate dehydrogenase, puta... 561 e-158
gi|114658864|ref|XP_001168316.1| PREDICTED: isocitrate dehy... 560 e-158
gi|168052303|ref|XP_001778590.1| predicted protein [Physcom... 560 e-158
gi|115465563|ref|NP_001056381.1| Os05g0573200 [Oryza sativa... 560 e-158
gi|169989|gb|AAA33978.1| NADPH-specific isocitrate dehydrog... 560 e-158
gi|1708402|sp|P50218|IDHC_TOBAC Isocitrate dehydrogenase [N... 560 e-158
gi|145553437|ref|XP_001462393.1| hypothetical protein GSPAT... 560 e-157
gi|479386|pir||S33612 isocitrate dehydrogenase (NADP) (EC 1... 559 e-157
gi|17540874|ref|NP_501665.1| F59B8.2 [Caenorhabditis elegan... 559 e-157
gi|41054651|ref|NP_955858.1| isocitrate dehydrogenase 2 (NA... 559 e-157
gi|145537055|ref|XP_001454244.1| hypothetical protein GSPAT... 559 e-157
gi|115438939|ref|NP_001043749.1| Os01g0654500 [Oryza sativa... 558 e-157
gi|115459338|ref|NP_001053269.1| Os04g0508200 [Oryza sativa... 558 e-157
>gi|71754537|ref|XP_828183.1| isocitrate dehydrogenase [Trypanosoma brucei TREU927]
gi|70833569|gb|EAN79071.1| isocitrate dehydrogenase, putative [Trypanosoma brucei]
Length = 413
Score = 858 bits (2216), Expect = 0.0, Method: Composition-based stats.
Identities = 413/413 (100%), Positives = 413/413 (100%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA
Sbjct: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL
Sbjct: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGGVMMG 180
VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGGVMMG
Sbjct: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGGVMMG 180
Query: 181 MYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKT 240
MYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKT
Sbjct: 181 MYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKT 240
Query: 241 CGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGK 300
CGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGK
Sbjct: 241 CGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGK 300
Query: 301 TVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLED 360
TVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLED
Sbjct: 301 TVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLED 360
Query: 361 VIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
VIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV
Sbjct: 361 VIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
>gi|71659757|ref|XP_821599.1| isocitrate dehydrogenase, putative [Trypanosoma cruzi strain CL
Brener]
gi|70886982|gb|EAN99748.1| isocitrate dehydrogenase, putative [Trypanosoma cruzi]
Length = 413
Score = 681 bits (1756), Expect = 0.0, Method: Composition-based stats.
Identities = 311/413 (75%), Positives = 364/413 (88%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M KI G +VELDGDEMTRVIWK IKE LIFPF++VPIEYYDL MENRDKT+D+VTV+A
Sbjct: 1 MQKIKVAGTVVELDGDEMTRVIWKMIKEELIFPFLDVPIEYYDLGMENRDKTDDQVTVDA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A+AIKKHGVGVKCATITPDEARV+EFNLK+MW+SPNGTIR ILGGTVFREPI+C NVPRL
Sbjct: 61 AHAIKKHGVGVKCATITPDEARVREFNLKQMWKSPNGTIRNILGGTVFREPIMCKNVPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGGVMMG 180
VTTWK P+VIGRHAFGDQY ATD VV PGTFE+ F+P +GG +V KVFD+KSGGV+MG
Sbjct: 121 VTTWKHPIVIGRHAFGDQYRATDLVVNGPGTFEIHFVPESGGAAQVQKVFDFKSGGVLMG 180
Query: 181 MYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKT 240
MYNTD+SI+DFA+SCFE+AL++KWPLYLSTKNTILK YDGRFKDIFAEMYKA YE +K
Sbjct: 181 MYNTDESIKDFAKSCFEYALSKKWPLYLSTKNTILKRYDGRFKDIFAEMYKASYEADYKK 240
Query: 241 CGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGK 300
GI+YEHRLIDDMVA+ M+SEGGYVWACKNYDGDVQSDS+AQGFGSLG+MTS+LM+PDG+
Sbjct: 241 AGIWYEHRLIDDMVAYAMKSEGGYVWACKNYDGDVQSDSVAQGFGSLGLMTSVLMSPDGR 300
Query: 301 TVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLED 360
TVE EAAHGTVTRHYR +QKG+ETSTNPVASIFAWTR L HR ++D N L++F+ LE
Sbjct: 301 TVEAEAAHGTVTRHYRQHQKGEETSTNPVASIFAWTRGLMHRGKLDQNEKLVQFSMLLEK 360
Query: 361 VIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
V+++TIEAG MT+DLAICIKG +V R+DYLNT EFI ++ ++ A ++SK+
Sbjct: 361 VVVSTIEAGFMTKDLAICIKGMNHVTRSDYLNTQEFIHKLADEMRKAYERSKI 413
>gi|157109449|ref|XP_001650675.1| nadp-specific isocitrate dehydrogenase [Aedes aegypti]
gi|94469026|gb|ABF18362.1| NADP-dependent isocitrate dehydrogenase [Aedes aegypti]
gi|108883996|gb|EAT48221.1| nadp-specific isocitrate dehydrogenase [Aedes aegypti]
Length = 409
Score = 593 bits (1530), Expect = e-168, Method: Composition-based stats.
Identities = 280/406 (68%), Positives = 330/406 (81%), Gaps = 1/406 (0%)
Query: 3 KISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEAAY 62
KI A G +V++ GDEMTR+IW IKE LI PF+++ + YDL ME+RDKT+D+VT++ A
Sbjct: 4 KIKA-GPVVDILGDEMTRIIWDSIKEKLILPFLDIELHTYDLGMEHRDKTDDQVTIDCAE 62
Query: 63 AIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRLVT 122
A+KK+ VG+KCATITPDEARVKEFNLKKMWRSPNGTIR ILGGTVFRE IIC N+PRLV
Sbjct: 63 AVKKYNVGIKCATITPDEARVKEFNLKKMWRSPNGTIRNILGGTVFREAIICKNIPRLVP 122
Query: 123 TWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGGVMMGMY 182
W+KP+VIGRHA GDQY ATD VV G E++F P GGEP Y V YK GV M MY
Sbjct: 123 GWEKPIVIGRHAHGDQYKATDFVVPGAGDLEIKFTPKAGGEPISYVVHQYKGPGVAMAMY 182
Query: 183 NTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKTCG 242
N DDSI DFA S F+ AL RK+PLYLSTKNTILK YDGRFKDIF E+Y+ Y+T+F+ G
Sbjct: 183 NLDDSIVDFAHSSFKVALDRKFPLYLSTKNTILKKYDGRFKDIFQEIYEKEYKTQFEAAG 242
Query: 243 IFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGKTV 302
I+YEHRLIDDMVA+CM++EGG+VWACKNYDGDVQSD++AQGFGSLG+MTS+L+ PDGKTV
Sbjct: 243 IWYEHRLIDDMVAYCMKAEGGFVWACKNYDGDVQSDTVAQGFGSLGLMTSVLVCPDGKTV 302
Query: 303 EVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLEDVI 362
E EAAHGTVTRHYR YQ+GKETSTNP+ASIFAWTR L HRA++DNN L +F + LE V
Sbjct: 303 EAEAAHGTVTRHYRQYQQGKETSTNPIASIFAWTRGLLHRAKLDNNAELKKFAETLEKVC 362
Query: 363 IATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAM 408
I TIE+G+MT+DLAICIKG NV RADYL T EF+ + LK A+
Sbjct: 363 IDTIESGSMTKDLAICIKGMANVTRADYLETFEFMTKLGDNLKAAL 408
>gi|159481269|ref|XP_001698704.1| isocitrate dehydrogenase, NADP-dependent [Chlamydomonas
reinhardtii]
gi|158273598|gb|EDO99386.1| isocitrate dehydrogenase, NADP-dependent [Chlamydomonas
reinhardtii]
Length = 483
Score = 590 bits (1521), Expect = e-167, Method: Composition-based stats.
Identities = 268/399 (67%), Positives = 325/399 (81%)
Query: 3 KISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEAAY 62
KI +V+LDGDEMTRVIW++IK+ LI P++++ I Y+DL + NRDKT D+VT EAAY
Sbjct: 74 KIHVANPVVDLDGDEMTRVIWQQIKDKLILPYLDLKIVYFDLGLPNRDKTNDKVTEEAAY 133
Query: 63 AIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRLVT 122
AIK+H VG+KCATITPDEARVKEF LKKMW+SPNGTIR IL GTVFREPI+ SN+PRLV
Sbjct: 134 AIKEHNVGIKCATITPDEARVKEFGLKKMWKSPNGTIRNILNGTVFREPIVISNIPRLVP 193
Query: 123 TWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGGVMMGMY 182
W KP+V+GRHAFGDQY ATD VV PG EM F PA GG P+ ++V+ ++ GV MGMY
Sbjct: 194 GWTKPIVVGRHAFGDQYKATDFVVDGPGKLEMIFTPAAGGAPRKFEVYSFEGPGVAMGMY 253
Query: 183 NTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKTCG 242
NT++SIR FA SCFE+AL ++WPLYLSTKNTILK YDGRF IFAE Y+ Y+ +++ G
Sbjct: 254 NTEESIRGFASSCFEYALQKRWPLYLSTKNTILKSYDGRFLQIFAETYETQYKKQYEEAG 313
Query: 243 IFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGKTV 302
I+YEHRLIDDMVA ++S GG+VWACKNYDGDVQSD +AQG+GSLG+MTS+L+TPDGKTV
Sbjct: 314 IWYEHRLIDDMVAQGLKSSGGFVWACKNYDGDVQSDIVAQGYGSLGLMTSVLVTPDGKTV 373
Query: 303 EVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLEDVI 362
E EAAHGTVTRH+R+YQKGK TSTNPVASIFAWTR LAHR ++DNN L+++T LE +
Sbjct: 374 EAEAAHGTVTRHWREYQKGKPTSTNPVASIFAWTRGLAHRGKLDNNAELIQWTHDLEAAV 433
Query: 363 IATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVS 401
I TIE G MT+DLAIC+ G V YLNT+ F+DAV+
Sbjct: 434 IETIEQGHMTKDLAICVHGTTKVTPDQYLNTEPFMDAVA 472
>gi|170028051|ref|XP_001841910.1| isocitrate dehydrogenase cytoplasmic [Culex pipiens
quinquefasciatus]
gi|167868380|gb|EDS31763.1| isocitrate dehydrogenase cytoplasmic [Culex pipiens
quinquefasciatus]
Length = 409
Score = 589 bits (1519), Expect = e-166, Method: Composition-based stats.
Identities = 278/406 (68%), Positives = 331/406 (81%), Gaps = 1/406 (0%)
Query: 3 KISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEAAY 62
KI A G +V++ GDEMTR+IW IKE LI PF+++ + +DL +E+RDKTED+VTV+ A
Sbjct: 4 KIKA-GPVVDILGDEMTRIIWDSIKEKLILPFLDIELHTFDLGIEHRDKTEDQVTVDCAE 62
Query: 63 AIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRLVT 122
AIKK+ VG+KCATITPDEARV+EF LK+MWRSPNGTIR ILGGTVFRE IIC NVPRLV
Sbjct: 63 AIKKYNVGIKCATITPDEARVEEFKLKQMWRSPNGTIRNILGGTVFREAIICKNVPRLVP 122
Query: 123 TWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGGVMMGMY 182
W+KP+VIGRHA GDQY ATD VV GT E++F P++GGEP Y V YK GV M MY
Sbjct: 123 GWEKPIVIGRHAHGDQYKATDFVVPGAGTLELKFTPSSGGEPISYVVNQYKGPGVAMAMY 182
Query: 183 NTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKTCG 242
N DDSIRDFA S F+ AL RK+PLYLSTKNTILK YDGRFKDIF E+Y+A Y+ +++ G
Sbjct: 183 NLDDSIRDFAHSSFKVALDRKFPLYLSTKNTILKKYDGRFKDIFQEIYEADYKKQYEAAG 242
Query: 243 IFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGKTV 302
I+YEHRLIDDMVA+CM++EGG+VWACKNYDGDVQSD++AQGFGSLG+MTS+L+ PDGKTV
Sbjct: 243 IWYEHRLIDDMVAYCMKAEGGFVWACKNYDGDVQSDTVAQGFGSLGLMTSVLVCPDGKTV 302
Query: 303 EVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLEDVI 362
E EAAHGTVTRHYR YQ+GKETSTNP+ASIFAWTR L HRA++DNN L +F + LE V
Sbjct: 303 EAEAAHGTVTRHYRQYQQGKETSTNPIASIFAWTRGLLHRAKLDNNAELKKFAETLEKVC 362
Query: 363 IATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAM 408
I TIE+G MT+DLAICIKG V R+DYL T EF+ + LK A+
Sbjct: 363 IDTIESGFMTKDLAICIKGMSGVQRSDYLETFEFMTKLGDNLKAAL 408
>gi|158296265|ref|XP_001688948.1| AGAP006660-PA [Anopheles gambiae str. PEST]
gi|158296267|ref|XP_001688949.1| AGAP006660-PB [Anopheles gambiae str. PEST]
gi|158296269|ref|XP_316694.4| AGAP006660-PC [Anopheles gambiae str. PEST]
gi|157016428|gb|EDO63954.1| AGAP006660-PA [Anopheles gambiae str. PEST]
gi|157016429|gb|EDO63955.1| AGAP006660-PB [Anopheles gambiae str. PEST]
gi|157016430|gb|EAA11493.4| AGAP006660-PC [Anopheles gambiae str. PEST]
Length = 413
Score = 586 bits (1510), Expect = e-165, Method: Composition-based stats.
Identities = 272/412 (66%), Positives = 334/412 (81%), Gaps = 1/412 (0%)
Query: 2 NKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEAA 61
+KI A G +V++ GDEMTR+IW IKE LI PF+++ + YDL +E+RD T D+VT++ A
Sbjct: 3 SKIKA-GPVVDILGDEMTRIIWDSIKEKLILPFLDIELHTYDLGIEHRDATNDQVTIDCA 61
Query: 62 YAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRLV 121
A+K++ VG+KCATITPDEARV+EF LK+MWRSPNGTIR ILGGTVFRE IIC NVPRLV
Sbjct: 62 EAVKRYNVGIKCATITPDEARVEEFKLKQMWRSPNGTIRNILGGTVFREAIICKNVPRLV 121
Query: 122 TTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGGVMMGM 181
W+KP++IGRHA GDQY ATD VV PG EM+F PA+G EP Y V +YKS GV MGM
Sbjct: 122 PGWEKPIIIGRHAHGDQYKATDFVVPVPGKLEMKFTPADGSEPTTYVVNEYKSAGVAMGM 181
Query: 182 YNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKTC 241
YN DDSI DFA S F+ AL RK+PLYLSTKNTILK YDGRFKDIF E+Y Y+ +F+
Sbjct: 182 YNLDDSICDFAHSSFKVALDRKFPLYLSTKNTILKKYDGRFKDIFQEIYDKDYKKQFEAL 241
Query: 242 GIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGKT 301
GI+YEHRLIDDMVA+CM++EGG+VWACKNYDGDVQSD++AQGFGSLG+MTS+L+ PDG+T
Sbjct: 242 GIWYEHRLIDDMVAYCMKAEGGFVWACKNYDGDVQSDTVAQGFGSLGLMTSVLVCPDGRT 301
Query: 302 VEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLEDV 361
VE EAAHGTVTRHYR +Q+GKETSTNP+ASIFAWTR L HRA++D+N L F + LE V
Sbjct: 302 VESEAAHGTVTRHYRQHQQGKETSTNPIASIFAWTRGLLHRAKLDDNAELKRFAETLEKV 361
Query: 362 IIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
I TIE+G MT+DLAICIKG NV R DY+ T EF++ + + L+ A+ +S++
Sbjct: 362 CIDTIESGFMTKDLAICIKGMANVKRTDYMETFEFMNKLGENLQAALTQSRL 413
>gi|118093509|ref|XP_421965.2| PREDICTED: similar to cytosolic NADP-dependent isocitrate
dehydrogenase [Gallus gallus]
Length = 415
Score = 585 bits (1509), Expect = e-165, Method: Composition-based stats.
Identities = 274/406 (67%), Positives = 331/406 (81%), Gaps = 1/406 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M+K G +VE+ GDEMTRVIW+ IKE LIFP+V++ + YDL +E+RD T D+VTVEA
Sbjct: 1 MSKKIHGGSVVEMQGDEMTRVIWELIKEKLIFPYVDLDLHSYDLGIEHRDATNDKVTVEA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIKK+ VG+KCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 61 AEAIKKYHVGIKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKS-GGVMM 179
V+ W KP+VIGRHA+GDQY ATD VV PG EM + P +GG+P Y V +++S GGV M
Sbjct: 121 VSGWVKPIVIGRHAYGDQYRATDFVVPGPGKVEMTYTPGDGGKPVTYLVHNFESCGGVAM 180
Query: 180 GMYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFK 239
GMYN D SI+DFA S F+ AL++ WPLY+STKNTILK YDGRFKDIF E+Y Y+++F+
Sbjct: 181 GMYNLDQSIKDFAHSSFQMALSKGWPLYMSTKNTILKRYDGRFKDIFQEIYDREYKSQFE 240
Query: 240 TCGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDG 299
I+YEHRLIDDMVA ++SEGG+VWACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDG
Sbjct: 241 AKKIWYEHRLIDDMVAQALKSEGGFVWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDG 300
Query: 300 KTVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLE 359
KTVE EAAHGTVTRHYR +QKG+ETSTNP+ASIFAWTR LAHRA++DNN +L F LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMHQKGQETSTNPIASIFAWTRGLAHRAKLDNNTSLKTFATALE 360
Query: 360 DVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLK 405
+V I TIE+G MT+DLA CIKG NV R+DYLNT EF+D ++ LK
Sbjct: 361 EVCIETIESGFMTKDLAACIKGLPNVTRSDYLNTFEFMDKLAANLK 406
>gi|155966095|gb|ABU41004.1| isocitrate dehydrogenase 1 [Anser anser]
Length = 415
Score = 585 bits (1508), Expect = e-165, Method: Composition-based stats.
Identities = 273/406 (67%), Positives = 332/406 (81%), Gaps = 1/406 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M+K G +VE+ GDEMTRVIW+ IKE LIFP+V++ + YDL +E+RD T D+VTVEA
Sbjct: 1 MSKKIHGGSVVEMQGDEMTRVIWELIKEKLIFPYVDLDLHSYDLGIEHRDATNDKVTVEA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIKK+ VG+KCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 61 AEAIKKYHVGIKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKS-GGVMM 179
V+ W KP+VIGRHA+GDQY ATD VV PG EM + P +GG+P Y V +++S GGV M
Sbjct: 121 VSGWVKPIVIGRHAYGDQYRATDFVVPGPGKVEMTYTPGDGGKPVTYLVHNFESCGGVAM 180
Query: 180 GMYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFK 239
GM+N D SI+DFA S F+ AL++ WPLY+STKNTILK YDGRFKDIF E+Y Y+++F+
Sbjct: 181 GMFNLDQSIKDFAHSSFQMALSKGWPLYMSTKNTILKRYDGRFKDIFQEIYDREYKSQFE 240
Query: 240 TCGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDG 299
I+YEHRLIDDMVA ++SEGG+VWACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDG
Sbjct: 241 AKKIWYEHRLIDDMVAQALKSEGGFVWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDG 300
Query: 300 KTVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLE 359
KTVE EAAHGTVTRHYR +QKG+ETSTNP+ASIFAWTR LAHRA++DNN +L F LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMHQKGQETSTNPIASIFAWTRGLAHRAKLDNNTSLKTFAAALE 360
Query: 360 DVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLK 405
+V I TIE+G MT+DLA CIKG NV R+DYLNT EF+D +++ LK
Sbjct: 361 EVCIETIESGFMTKDLAACIKGLPNVTRSDYLNTFEFMDKLAENLK 406
>gi|49168486|emb|CAG38738.1| IDH1 [Homo sapiens]
Length = 414
Score = 584 bits (1506), Expect = e-165, Method: Composition-based stats.
Identities = 274/414 (66%), Positives = 332/414 (80%), Gaps = 1/414 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M+K + G +VE+ GDEMTR+IW+ IKE LIFP+V + + YDL +ENRD T D+VT +A
Sbjct: 1 MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIKKH VGVKCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 61 AEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGG-VMM 179
V+ W KP++IGRHA+GDQY ATD VV PG EM + P++G + Y V +++ GG V M
Sbjct: 121 VSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEMTYTPSDGTQKVTYLVHNFEEGGGVAM 180
Query: 180 GMYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFK 239
GMYN D SI DFA S F+ AL++ WPLYLSTKNTILK YDGRFKDIF E+Y Y+++F+
Sbjct: 181 GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE 240
Query: 240 TCGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDG 299
I+YEHRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDG
Sbjct: 241 AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG 300
Query: 300 KTVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLE 359
KTVE EAAHGTVTRHYR YQKG+ETSTNP+ASIFAWTR LAHRA++DNN L F LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALE 360
Query: 360 DVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
+V I TIEAG MT+DLA CIKG NV R+DYLNT EF+D + + LK+ + ++K+
Sbjct: 361 EVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL 414
>gi|57164307|ref|NP_001009276.1| cytosolic NADP-isocitrate dehydrogenase [Ovis aries]
gi|75053124|sp|Q6XUZ5|IDHC_SHEEP Isocitrate dehydrogenase [NADP] cytoplasmic (Cytosolic
NADP-isocitrate dehydrogenase) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP)
gi|37784370|gb|AAP41947.1| cytosolic NADP-isocitrate dehydrogenase [Ovis aries]
Length = 414
Score = 583 bits (1503), Expect = e-165, Method: Composition-based stats.
Identities = 271/407 (66%), Positives = 332/407 (81%), Gaps = 1/407 (0%)
Query: 8 GVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEAAYAIKKH 67
G +VE+ GDEMTR+IW+ IKE LIFP+V++ + YDLS+ENRD T D+VT +AA AIKK+
Sbjct: 8 GSVVEMQGDEMTRIIWELIKEKLIFPYVDLDLHSYDLSIENRDATNDQVTKDAAEAIKKY 67
Query: 68 GVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRLVTTWKKP 127
VGVKCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRLV+ W KP
Sbjct: 68 NVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKP 127
Query: 128 VVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDY-KSGGVMMGMYNTDD 186
++IGRHA+GDQY ATD VV PG E+ + P++G VY V ++ +SGGV MGM+N D
Sbjct: 128 IIIGRHAYGDQYRATDFVVPGPGKVEICYTPSDGSPKTVYLVHNFTESGGVAMGMFNQDK 187
Query: 187 SIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKTCGIFYE 246
SI DFA S F+ AL++ WPLYLSTKNTILK YDGRFKDIF E+Y Y+++F+ I+YE
Sbjct: 188 SIEDFAHSSFQMALSKNWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQNIWYE 247
Query: 247 HRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGKTVEVEA 306
HRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDGKTVE EA
Sbjct: 248 HRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEA 307
Query: 307 AHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLEDVIIATI 366
AHGTVTRHYR YQKG+ETSTNP+ASIFAWTR LAHRA++DNN L F + LE+V I TI
Sbjct: 308 AHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELSFFAKALEEVCIETI 367
Query: 367 EAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
EAG MT+DLA CIKG NV R+DYLNT EF+D + + L++ + ++K+
Sbjct: 368 EAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLQLKLAQAKL 414
>gi|74005281|ref|XP_860821.1| PREDICTED: similar to Isocitrate dehydrogenase [NADP] cytoplasmic
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) (IDP) isoform 4 [Canis familiaris]
Length = 415
Score = 583 bits (1503), Expect = e-165, Method: Composition-based stats.
Identities = 270/408 (66%), Positives = 328/408 (80%), Gaps = 2/408 (0%)
Query: 8 GVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEAAYAIKKH 67
G +VE+ GDEMTR+IW+ IKE LIFP+V + + YDL +ENRD T D+VT +AA AIKK+
Sbjct: 8 GSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKY 67
Query: 68 GVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRLVTTWKKP 127
VGVKCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRLV+ W KP
Sbjct: 68 NVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKP 127
Query: 128 VVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVY--KVFDYKSGGVMMGMYNTD 185
++IGRHA+GDQY ATD VV PG E+ + P++G E Y +V +K GGV MGMYN D
Sbjct: 128 IIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGSEKMTYLIQVLSFKGGGVAMGMYNQD 187
Query: 186 DSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKTCGIFY 245
SI DFA S F+ AL++ WPLYLSTKNTILK YDGRFKDIF E+Y Y+++F+ I+Y
Sbjct: 188 KSIEDFAHSSFQMALSKSWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQNIWY 247
Query: 246 EHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGKTVEVE 305
EHRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDGKTVE E
Sbjct: 248 EHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAE 307
Query: 306 AAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLEDVIIAT 365
AAHGTVTRHYR YQKG+ETSTNP+ASIFAWTR LAHRA++DNN L F + LE+V + T
Sbjct: 308 AAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELSFFAKALEEVCVET 367
Query: 366 IEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
IEAG MT+DLA CIKG NV R+DYLNT EF+D + + L + + ++K+
Sbjct: 368 IEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLNIKLAQAKL 415
>gi|149641842|ref|XP_001511049.1| PREDICTED: similar to cytosolic NADP-dependent isocitrate
dehydrogenase [Ornithorhynchus anatinus]
Length = 415
Score = 583 bits (1503), Expect = e-165, Method: Composition-based stats.
Identities = 270/402 (67%), Positives = 326/402 (81%), Gaps = 1/402 (0%)
Query: 8 GVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEAAYAIKKH 67
G +VE+ GDEMTRVIW+ IKE LIFP+V++ + YDL +ENRD T D+VT EAA AIKK+
Sbjct: 8 GSVVEMQGDEMTRVIWELIKEKLIFPYVDLDLHSYDLGIENRDATNDKVTSEAAEAIKKY 67
Query: 68 GVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRLVTTWKKP 127
VG+KCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRLV+ W KP
Sbjct: 68 NVGIKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKP 127
Query: 128 VVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGG-VMMGMYNTDD 186
++IGRHA+GDQY ATD VV PG EM + P +GG+ Y V ++++GG V MGMYN D
Sbjct: 128 IIIGRHAYGDQYRATDFVVPRPGKVEMVYTPQDGGKAVTYLVHNFEAGGGVAMGMYNLDQ 187
Query: 187 SIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKTCGIFYE 246
SIRDFA S F+ AL++ WPLY+STKNTILK YDGRFKDIF E+Y+ Y +KF+ I+YE
Sbjct: 188 SIRDFAHSSFQMALSKSWPLYMSTKNTILKRYDGRFKDIFQEIYEKQYRSKFEAKKIWYE 247
Query: 247 HRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGKTVEVEA 306
HRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDGKTVE EA
Sbjct: 248 HRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDGKTVEAEA 307
Query: 307 AHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLEDVIIATI 366
AHGTVTRH+R +QKG+ETSTNP+ASIFAW+R LAHRA++DNN L F LEDV + TI
Sbjct: 308 AHGTVTRHFRMHQKGQETSTNPIASIFAWSRGLAHRAKLDNNTELSTFATTLEDVCVETI 367
Query: 367 EAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAM 408
EAG MT+DLA CIKG NV R+DYLNT EF+D + + LK +
Sbjct: 368 EAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKAKL 409
>gi|109100767|ref|XP_001107627.1| PREDICTED: isocitrate dehydrogenase 1 (NADP+), soluble isoform 1
[Macaca mulatta]
gi|109100769|ref|XP_001107810.1| PREDICTED: isocitrate dehydrogenase 1 (NADP+), soluble isoform 2
[Macaca mulatta]
gi|109100771|ref|XP_001107875.1| PREDICTED: isocitrate dehydrogenase 1 (NADP+), soluble isoform 3
[Macaca mulatta]
gi|109100773|ref|XP_001107934.1| PREDICTED: isocitrate dehydrogenase 1 (NADP+), soluble isoform 4
[Macaca mulatta]
gi|109100775|ref|XP_001107992.1| PREDICTED: isocitrate dehydrogenase 1 (NADP+), soluble isoform 5
[Macaca mulatta]
Length = 414
Score = 583 bits (1502), Expect = e-164, Method: Composition-based stats.
Identities = 273/414 (65%), Positives = 333/414 (80%), Gaps = 1/414 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M+K + G +VEL GDEMTR+IW+ IKE LIFP+V + ++ YDL +ENRD T D+VT +A
Sbjct: 1 MSKKISGGSVVELQGDEMTRIIWELIKEKLIFPYVELDLQSYDLGIENRDATNDQVTKDA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIKK+ VGVKCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 61 AEAIKKYNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGG-VMM 179
V+ W KP++IGRHA+GDQY ATD VV PG E+ + P++G + Y V +++ GG V M
Sbjct: 121 VSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAM 180
Query: 180 GMYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFK 239
GMYN D SI DFA S F+ AL++ WPLYLSTKNTILK YDGRFKDIF E+Y Y+++F+
Sbjct: 181 GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE 240
Query: 240 TCGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDG 299
I+YEHRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDG
Sbjct: 241 AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG 300
Query: 300 KTVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLE 359
KTVE EAAHGTVTRHYR YQKG+ETSTNP+ASIFAWTR LAHRA++DNN L F LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALE 360
Query: 360 DVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
+V I TIEAG MT+DLA CIKG NV R+DYLNT EF+D + + LK+ + ++K+
Sbjct: 361 EVCIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL 414
>gi|28178825|ref|NP_005887.2| isocitrate dehydrogenase 1 (NADP+), soluble [Homo sapiens]
gi|21903432|sp|O75874|IDHC_HUMAN Isocitrate dehydrogenase [NADP] cytoplasmic (Cytosolic
NADP-isocitrate dehydrogenase) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP)
gi|50513663|pdb|1T09|A Chain A, Crystal Structure Of Human Cytosolic Nadp(+)-Dependent
Isocitrate Dehydrogenase In Complex Nadp
gi|50513664|pdb|1T09|B Chain B, Crystal Structure Of Human Cytosolic Nadp(+)-Dependent
Isocitrate Dehydrogenase In Complex Nadp
gi|50513678|pdb|1T0L|A Chain A, Crystal Structure Of Human Cytosolic Nadp(+)-Dependent
Isocitrate Dehydrogenase In Complex With Nadp,
Isocitrate, And Calcium(2+)
gi|50513679|pdb|1T0L|B Chain B, Crystal Structure Of Human Cytosolic Nadp(+)-Dependent
Isocitrate Dehydrogenase In Complex With Nadp,
Isocitrate, And Calcium(2+)
gi|50513680|pdb|1T0L|C Chain C, Crystal Structure Of Human Cytosolic Nadp(+)-Dependent
Isocitrate Dehydrogenase In Complex With Nadp,
Isocitrate, And Calcium(2+)
gi|50513681|pdb|1T0L|D Chain D, Crystal Structure Of Human Cytosolic Nadp(+)-Dependent
Isocitrate Dehydrogenase In Complex With Nadp,
Isocitrate, And Calcium(2+)
gi|4761223|gb|AAD29284.1|AF113917_1 NADP+-dependent isocitrate dehydrogenase [Homo sapiens]
gi|15277488|gb|AAH12846.1| IDH1 protein [Homo sapiens]
gi|49456351|emb|CAG46496.1| IDH1 [Homo sapiens]
gi|62702297|gb|AAX93221.1| unknown [Homo sapiens]
gi|119590845|gb|EAW70439.1| isocitrate dehydrogenase 1 (NADP+), soluble, isoform CRA_a [Homo
sapiens]
gi|119590847|gb|EAW70441.1| isocitrate dehydrogenase 1 (NADP+), soluble, isoform CRA_a [Homo
sapiens]
gi|119590848|gb|EAW70442.1| isocitrate dehydrogenase 1 (NADP+), soluble, isoform CRA_a [Homo
sapiens]
gi|123981064|gb|ABM82361.1| isocitrate dehydrogenase 1 (NADP+), soluble [synthetic construct]
gi|157928200|gb|ABW03396.1| isocitrate dehydrogenase 1 (NADP+), soluble [synthetic construct]
Length = 414
Score = 582 bits (1501), Expect = e-164, Method: Composition-based stats.
Identities = 273/414 (65%), Positives = 332/414 (80%), Gaps = 1/414 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M+K + G +VE+ GDEMTR+IW+ IKE LIFP+V + + YDL +ENRD T D+VT +A
Sbjct: 1 MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIKKH VGVKCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 61 AEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGG-VMM 179
V+ W KP++IGRHA+GDQY ATD VV PG E+ + P++G + Y V +++ GG V M
Sbjct: 121 VSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAM 180
Query: 180 GMYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFK 239
GMYN D SI DFA S F+ AL++ WPLYLSTKNTILK YDGRFKDIF E+Y Y+++F+
Sbjct: 181 GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE 240
Query: 240 TCGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDG 299
I+YEHRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDG
Sbjct: 241 AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG 300
Query: 300 KTVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLE 359
KTVE EAAHGTVTRHYR YQKG+ETSTNP+ASIFAWTR LAHRA++DNN L F LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALE 360
Query: 360 DVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
+V I TIEAG MT+DLA CIKG NV R+DYLNT EF+D + + LK+ + ++K+
Sbjct: 361 EVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL 414
>gi|75832090|ref|NP_851355.2| isocitrate dehydrogenase 1 (NADP+), soluble [Bos taurus]
gi|74354744|gb|AAI03369.1| Isocitrate dehydrogenase 1 (NADP+), soluble [Bos taurus]
Length = 414
Score = 582 bits (1501), Expect = e-164, Method: Composition-based stats.
Identities = 271/407 (66%), Positives = 330/407 (81%), Gaps = 1/407 (0%)
Query: 8 GVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEAAYAIKKH 67
G +VE+ GDEMTR+IW+ IKE LIFP+V + + YDL +ENRD T D+VT +AA AIKK+
Sbjct: 8 GSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKY 67
Query: 68 GVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRLVTTWKKP 127
VGVKCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRLV+ W KP
Sbjct: 68 NVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKP 127
Query: 128 VVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDY-KSGGVMMGMYNTDD 186
++IGRHA+GDQY ATD VV PG E+ + P++G VY V ++ +SGGV MGMYN D
Sbjct: 128 IIIGRHAYGDQYRATDFVVPGPGKVEISYTPSDGSPKTVYLVHNFTESGGVAMGMYNQDK 187
Query: 187 SIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKTCGIFYE 246
SI DFA S F+ AL++ WPLYLSTKNTILK YDGRFKDIF E+Y Y+++F+ I+YE
Sbjct: 188 SIEDFAHSSFQMALSKNWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSEFEAQNIWYE 247
Query: 247 HRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGKTVEVEA 306
HRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDGKTVE EA
Sbjct: 248 HRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEA 307
Query: 307 AHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLEDVIIATI 366
AHGTVTRHYR YQKG+ETSTNP+ASIFAWTR LAHRA++DNN L F + LE+V I TI
Sbjct: 308 AHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELSFFAKALEEVCIETI 367
Query: 367 EAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
EAG MT+DLA CIKG NV R+DYLNT EF+D + + L++ + ++K+
Sbjct: 368 EAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLQLKLAQAKL 414
>gi|62203298|gb|AAH93020.1| Isocitrate dehydrogenase 1 (NADP+), soluble [Homo sapiens]
Length = 414
Score = 582 bits (1499), Expect = e-164, Method: Composition-based stats.
Identities = 272/414 (65%), Positives = 332/414 (80%), Gaps = 1/414 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M+K + G +VE+ GDEMTR+IW+ IKE LIFP+V + + YDL +ENRD T D+VT +A
Sbjct: 1 MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIKKH VGVKCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 61 AEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGG-VMM 179
V+ W KP++IGRHA+GDQY ATD VV PG E+ + P++G + Y V +++ GG V M
Sbjct: 121 VSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAM 180
Query: 180 GMYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFK 239
GMYN D SI DFA S F+ AL++ WPLYLSTKNTILK YDGRFKDIF E+Y Y+++F+
Sbjct: 181 GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE 240
Query: 240 TCGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDG 299
I+YEHRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDG
Sbjct: 241 AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG 300
Query: 300 KTVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLE 359
KTVE E+AHGTVTRHYR YQKG+ETSTNP+ASIFAWTR LAHRA++DNN L F LE
Sbjct: 301 KTVEAESAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALE 360
Query: 360 DVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
+V I TIEAG MT+DLA CIKG NV R+DYLNT EF+D + + LK+ + ++K+
Sbjct: 361 EVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL 414
>gi|31873324|emb|CAD97653.1| hypothetical protein [Homo sapiens]
gi|117645206|emb|CAL38069.1| hypothetical protein [synthetic construct]
gi|117646694|emb|CAL37462.1| hypothetical protein [synthetic construct]
Length = 414
Score = 581 bits (1497), Expect = e-164, Method: Composition-based stats.
Identities = 273/414 (65%), Positives = 331/414 (79%), Gaps = 1/414 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M+K + G +VE+ GDEMTR+IW+ IKE LIFP+V + + YDL +ENRD T D+VT +A
Sbjct: 1 MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIKKH VGVKCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 61 AEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGG-VMM 179
V+ W KP++IGRHA+GDQY ATD VV PG E+ + P++G + Y V + + GG V M
Sbjct: 121 VSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNSEGGGGVAM 180
Query: 180 GMYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFK 239
GMYN D SI DFA S F+ AL++ WPLYLSTKNTILK YDGRFKDIF E+Y Y+++F+
Sbjct: 181 GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE 240
Query: 240 TCGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDG 299
I+YEHRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDG
Sbjct: 241 AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG 300
Query: 300 KTVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLE 359
KTVE EAAHGTVTRHYR YQKG+ETSTNP+ASIFAWTR LAHRA++DNN L F LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALE 360
Query: 360 DVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
+V I TIEAG MT+DLA CIKG NV R+DYLNT EF+D + + LK+ + ++K+
Sbjct: 361 EVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL 414
>gi|149755011|ref|XP_001505172.1| PREDICTED: similar to Isocitrate dehydrogenase [NADP] cytoplasmic
(Cytosolic NADP-isocitrate dehydrogenase)
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) (IDP) [Equus caballus]
Length = 414
Score = 581 bits (1497), Expect = e-164, Method: Composition-based stats.
Identities = 270/407 (66%), Positives = 328/407 (80%), Gaps = 1/407 (0%)
Query: 8 GVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEAAYAIKKH 67
G +VE+ GDEMTR+IW+ IKE LIFP V + + YDL +ENRD T D+VT +AA AIKK+
Sbjct: 8 GSVVEMQGDEMTRIIWELIKEKLIFPHVELDLHSYDLGIENRDATNDQVTKDAAEAIKKY 67
Query: 68 GVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRLVTTWKKP 127
VGVKCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRLV+ W KP
Sbjct: 68 NVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKP 127
Query: 128 VVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGG-VMMGMYNTDD 186
++IGRHA+GDQY ATD VV PG E+ + P++G + + Y V +++ GG V MGMYN D
Sbjct: 128 IIIGRHAYGDQYRATDFVVPGPGRVEITYTPSDGSQKRTYLVHNFEEGGGVAMGMYNQDK 187
Query: 187 SIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKTCGIFYE 246
SI DFA S F+ AL++ WPLYLSTKNTILK YDGRFKDIF E+Y Y ++F+ I+YE
Sbjct: 188 SIEDFAHSSFQMALSKSWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYRSQFEAQKIWYE 247
Query: 247 HRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGKTVEVEA 306
HRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDGKTVE EA
Sbjct: 248 HRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEA 307
Query: 307 AHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLEDVIIATI 366
AHGTVTRHYR YQKG+ETSTNP+ASIFAWTR LAHRA++DNN L F + LEDV + TI
Sbjct: 308 AHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELGFFAKALEDVCVETI 367
Query: 367 EAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
EAG MT+DLA CIKG NV R+DYLNT EF+D + + LK+ + ++K+
Sbjct: 368 EAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL 414
>gi|148232240|ref|NP_001088022.1| hypothetical protein LOC494713 [Xenopus laevis]
gi|52221142|gb|AAH82651.1| LOC494713 protein [Xenopus laevis]
Length = 415
Score = 581 bits (1497), Expect = e-164, Method: Composition-based stats.
Identities = 270/409 (66%), Positives = 329/409 (80%), Gaps = 1/409 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M+K G +VE+ GDEMTRVIW IKE LI P+V + + YDL MENRD T+D+VTV+A
Sbjct: 1 MSKKINGGSVVEMQGDEMTRVIWDLIKEKLILPYVELDLHSYDLGMENRDATDDQVTVDA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIKK+ VG+KCATITPDE RV+EFNLK+MW+SPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 61 AEAIKKYNVGIKCATITPDEKRVEEFNLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKS-GGVMM 179
V+ W KP++IGRHA+GDQY ATD VV PG E+ F P +GGE Y + +++ GGV +
Sbjct: 121 VSGWIKPIIIGRHAYGDQYRATDFVVPGPGKVEISFTPKDGGEAIKYVIHNFEDCGGVAL 180
Query: 180 GMYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFK 239
GMYNTD SIRDFA S F+ AL++ WPLY+STKNTILK YDGRFKDIF E+Y+ Y+++F+
Sbjct: 181 GMYNTDQSIRDFAHSSFQMALSKSWPLYMSTKNTILKRYDGRFKDIFQEIYEKEYKSQFE 240
Query: 240 TCGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDG 299
I+YEHRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDG
Sbjct: 241 ENKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDG 300
Query: 300 KTVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLE 359
KTVE EAAHGTVTRHYR +QKG+ETSTNP+ASIFAW+R L HRA++DNN L F LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMHQKGQETSTNPIASIFAWSRGLDHRAKLDNNQELKNFATALE 360
Query: 360 DVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAM 408
+V I TIEAG MT+DLA CIKG NV R DYL+T EF+D + + L++ +
Sbjct: 361 EVCIETIEAGFMTKDLAACIKGLPNVQRGDYLSTFEFMDKLGENLQLKL 409
>gi|75056526|sp|Q9XSG3|IDHC_BOVIN Isocitrate dehydrogenase [NADP] cytoplasmic (Cytosolic
NADP-isocitrate dehydrogenase) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP)
gi|4959708|gb|AAD34457.1|AF136009_1 cytosolic NADP+-dependent isocitrate dehydrogenase [Bos taurus]
Length = 414
Score = 580 bits (1495), Expect = e-164, Method: Composition-based stats.
Identities = 270/407 (66%), Positives = 329/407 (80%), Gaps = 1/407 (0%)
Query: 8 GVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEAAYAIKKH 67
G +VE+ GDEMTR+IW+ IKE LIFP+V + + YDL +ENRD T D+VT +AA AIKK+
Sbjct: 8 GSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKY 67
Query: 68 GVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRLVTTWKKP 127
VGVKCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRLV+ W KP
Sbjct: 68 NVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKP 127
Query: 128 VVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDY-KSGGVMMGMYNTDD 186
++IGRHA+GDQY ATD VV PG E+ + P++G VY V ++ +SGGV MGMYN D
Sbjct: 128 IIIGRHAYGDQYRATDFVVPGPGKVEISYTPSDGSPKTVYLVHNFTESGGVAMGMYNQDK 187
Query: 187 SIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKTCGIFYE 246
SI DFA S F+ AL++ WPLYLSTKNTILK YDGRFKDIF E+Y Y+++F+ I+YE
Sbjct: 188 SIEDFAHSSFQMALSKNWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSEFEAQNIWYE 247
Query: 247 HRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGKTVEVEA 306
HRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDGKTVE EA
Sbjct: 248 HRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEA 307
Query: 307 AHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLEDVIIATI 366
AHGTVTRHYR YQKG+ET TNP+ASIFAWTR LAHRA++DNN L F + LE+V I TI
Sbjct: 308 AHGTVTRHYRMYQKGQETLTNPIASIFAWTRGLAHRAKLDNNKELSFFAKALEEVCIETI 367
Query: 367 EAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
EAG MT+DLA CIKG NV R+DYLNT EF+D + + L++ + ++K+
Sbjct: 368 EAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLQLKLAQAKL 414
>gi|74005285|ref|XP_850187.1| PREDICTED: similar to Isocitrate dehydrogenase [NADP] cytoplasmic
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) (IDP) isoform 2 [Canis familiaris]
gi|74005287|ref|XP_536047.2| PREDICTED: similar to Isocitrate dehydrogenase [NADP] cytoplasmic
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) (IDP) isoform 1 [Canis familiaris]
Length = 414
Score = 580 bits (1495), Expect = e-164, Method: Composition-based stats.
Identities = 269/407 (66%), Positives = 328/407 (80%), Gaps = 1/407 (0%)
Query: 8 GVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEAAYAIKKH 67
G +VE+ GDEMTR+IW+ IKE LIFP+V + + YDL +ENRD T D+VT +AA AIKK+
Sbjct: 8 GSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKY 67
Query: 68 GVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRLVTTWKKP 127
VGVKCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRLV+ W KP
Sbjct: 68 NVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKP 127
Query: 128 VVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGG-VMMGMYNTDD 186
++IGRHA+GDQY ATD VV PG E+ + P++G E Y V +++ GG V MGMYN D
Sbjct: 128 IIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGSEKMTYLVHNFEEGGGVAMGMYNQDK 187
Query: 187 SIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKTCGIFYE 246
SI DFA S F+ AL++ WPLYLSTKNTILK YDGRFKDIF E+Y Y+++F+ I+YE
Sbjct: 188 SIEDFAHSSFQMALSKSWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQNIWYE 247
Query: 247 HRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGKTVEVEA 306
HRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDGKTVE EA
Sbjct: 248 HRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEA 307
Query: 307 AHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLEDVIIATI 366
AHGTVTRHYR YQKG+ETSTNP+ASIFAWTR LAHRA++DNN L F + LE+V + TI
Sbjct: 308 AHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELSFFAKALEEVCVETI 367
Query: 367 EAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
EAG MT+DLA CIKG NV R+DYLNT EF+D + + L + + ++K+
Sbjct: 368 EAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLNIKLAQAKL 414
>gi|41393155|ref|NP_958907.1| isocitrate dehydrogenase 1 (NADP+), soluble [Danio rerio]
gi|28422788|gb|AAH46894.1| Isocitrate dehydrogenase 1 (NADP+), soluble [Danio rerio]
Length = 429
Score = 580 bits (1494), Expect = e-164, Method: Composition-based stats.
Identities = 270/409 (66%), Positives = 327/409 (79%), Gaps = 1/409 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M++ G +VE+ GDEMTRVIW+ IKE LIFP++ + + YDL MENRD T+D+VTVEA
Sbjct: 15 MSQKVKAGSVVEMQGDEMTRVIWELIKEKLIFPYLELDLHSYDLGMENRDATDDKVTVEA 74
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A A++++ VG+KCATITPDE RV+EF LK+MWRSPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 75 AEAVRRYNVGIKCATITPDEKRVEEFKLKQMWRSPNGTIRNILGGTVFREAIICKNIPRL 134
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYK-SGGVMM 179
V W KP++IGRHA GDQY ATD VV PGT EM + P NGGE + V D++ +GGV +
Sbjct: 135 VPGWIKPIIIGRHAHGDQYKATDFVVPGPGTVEMTYKPKNGGETLKFVVHDFEGTGGVAL 194
Query: 180 GMYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFK 239
GMYNTD SIRDFA S F+ L + WP+YLSTKNTILK YDGRFKDIF E+Y Y+ K++
Sbjct: 195 GMYNTDKSIRDFAHSSFQMGLNKGWPMYLSTKNTILKKYDGRFKDIFQEIYDKEYKAKYE 254
Query: 240 TCGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDG 299
GI+YEHRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDG
Sbjct: 255 AMGIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG 314
Query: 300 KTVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLE 359
+TVE EAAHGTVTRHYR +Q+GKETSTNP+ASIFAWTR L HRA +D N L F + LE
Sbjct: 315 RTVEAEAAHGTVTRHYRMHQQGKETSTNPIASIFAWTRGLLHRAELDKNAELRVFAEALE 374
Query: 360 DVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAM 408
V + TIEAG MT+DLAICIKG V R+DYLNT EF+D +++ LK+ +
Sbjct: 375 VVCVETIEAGFMTKDLAICIKGMSGVTRSDYLNTFEFLDKLAENLKIKL 423
>gi|114582991|ref|XP_001141655.1| PREDICTED: isocitrate dehydrogenase 1 (NADP+), soluble isoform 1
[Pan troglodytes]
gi|114582993|ref|XP_001141734.1| PREDICTED: isocitrate dehydrogenase 1 (NADP+), soluble isoform 2
[Pan troglodytes]
gi|114582995|ref|XP_001141810.1| PREDICTED: isocitrate dehydrogenase 1 (NADP+), soluble isoform 3
[Pan troglodytes]
gi|114582997|ref|XP_001141879.1| PREDICTED: isocitrate dehydrogenase 1 (NADP+), soluble isoform 4
[Pan troglodytes]
gi|114582999|ref|XP_001141947.1| PREDICTED: isocitrate dehydrogenase 1 (NADP+), soluble isoform 5
[Pan troglodytes]
gi|114583001|ref|XP_001142041.1| PREDICTED: isocitrate dehydrogenase 1 (NADP+), soluble isoform 6
[Pan troglodytes]
gi|114583003|ref|XP_001142113.1| PREDICTED: isocitrate dehydrogenase 1 (NADP+), soluble isoform 7
[Pan troglodytes]
gi|114583005|ref|XP_001142197.1| PREDICTED: isocitrate dehydrogenase 1 (NADP+), soluble isoform 8
[Pan troglodytes]
Length = 414
Score = 579 bits (1493), Expect = e-163, Method: Composition-based stats.
Identities = 272/414 (65%), Positives = 332/414 (80%), Gaps = 1/414 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M+K + G +VE+ GDEMTR+IW+ IKE LIFP+V + + YDL +ENRD T D+VT +A
Sbjct: 1 MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIKK+ VGVKCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 61 AEAIKKYNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGG-VMM 179
V+ W KP++IGRHA+GDQY ATD VV PG E+ + P++G + Y V +++ GG V M
Sbjct: 121 VSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAM 180
Query: 180 GMYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFK 239
GMYN D SI DFA S F+ AL++ WPLYLSTKNTILK YDGRFKDIF E+Y Y+++F+
Sbjct: 181 GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKRYKSQFE 240
Query: 240 TCGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDG 299
I+YEHRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDG
Sbjct: 241 AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG 300
Query: 300 KTVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLE 359
KTVE EAAHGTVTRHYR YQKG+ETSTNP+ASIFAWTR LAHRA++DNN L F LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALE 360
Query: 360 DVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
+V I TIEAG MT+DLA CIKG NV R+DYLNT EF+D + + LK+ + ++K+
Sbjct: 361 EVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL 414
>gi|169158156|emb|CAQ15240.1| isocitrate dehydrogenase 1 (NADP+), soluble [Danio rerio]
Length = 429
Score = 579 bits (1493), Expect = e-163, Method: Composition-based stats.
Identities = 270/409 (66%), Positives = 327/409 (79%), Gaps = 1/409 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M++ G +VE+ GDEMTRVIW+ IKE LIFP++ + + YDL MENRD T+D+VTVEA
Sbjct: 15 MSQKIKAGSVVEMQGDEMTRVIWELIKEKLIFPYLELDLHSYDLGMENRDATDDKVTVEA 74
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A A++++ VG+KCATITPDE RV+EF LK+MWRSPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 75 AEAVRRYNVGIKCATITPDEKRVEEFKLKQMWRSPNGTIRNILGGTVFREAIICKNIPRL 134
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYK-SGGVMM 179
V W KP++IGRHA GDQY ATD VV PGT EM + P NGGE + V D++ +GGV +
Sbjct: 135 VPGWIKPIIIGRHAHGDQYKATDFVVPGPGTVEMTYKPKNGGETLKFVVHDFEGTGGVAL 194
Query: 180 GMYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFK 239
GMYNTD SIRDFA S F+ L + WP+YLSTKNTILK YDGRFKDIF E+Y Y+ K++
Sbjct: 195 GMYNTDKSIRDFAHSSFQMGLNKGWPMYLSTKNTILKKYDGRFKDIFQEIYDKEYKAKYE 254
Query: 240 TCGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDG 299
GI+YEHRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDG
Sbjct: 255 AMGIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG 314
Query: 300 KTVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLE 359
+TVE EAAHGTVTRHYR +Q+GKETSTNP+ASIFAWTR L HRA +D N L F + LE
Sbjct: 315 RTVEAEAAHGTVTRHYRMHQQGKETSTNPIASIFAWTRGLLHRAELDKNAELRVFAEALE 374
Query: 360 DVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAM 408
V + TIEAG MT+DLAICIKG V R+DYLNT EF+D +++ LK+ +
Sbjct: 375 VVCVETIEAGFMTKDLAICIKGMSGVTRSDYLNTFEFLDKLAENLKIKL 423
>gi|115697799|ref|XP_001176537.1| PREDICTED: similar to Isocitrate dehydrogenase 2 (NADP+),
mitochondrial [Strongylocentrotus purpuratus]
gi|115744264|ref|XP_785580.2| PREDICTED: similar to Isocitrate dehydrogenase 2 (NADP+),
mitochondrial [Strongylocentrotus purpuratus]
Length = 449
Score = 579 bits (1492), Expect = e-163, Method: Composition-based stats.
Identities = 266/407 (65%), Positives = 324/407 (79%)
Query: 3 KISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEAAY 62
+I +VELDGDEMTRVIW+KIKETLIFP++NV YYDL + RD+T D+VTV+AA
Sbjct: 43 RIEVAKPVVELDGDEMTRVIWEKIKETLIFPYLNVECLYYDLGLPYRDQTNDQVTVDAAV 102
Query: 63 AIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRLVT 122
AIK+H VG+KCATITPDE RV EFNLK+MW+SPNGT+R ILGGTVFREPI+C +PRLV
Sbjct: 103 AIKEHNVGIKCATITPDEERVVEFNLKEMWKSPNGTLRNILGGTVFREPILCDTIPRLVP 162
Query: 123 TWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGGVMMGMY 182
W K + IGRHAFGDQY ATD V+KEPG FE+ F PA+G EP +VF++ GG M MY
Sbjct: 163 GWTKAITIGRHAFGDQYRATDMVIKEPGKFELVFSPASGAEPTRTEVFNFPGGGCGMAMY 222
Query: 183 NTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKTCG 242
NTD+SI FA SCF++ALA+KWPLYLSTKNTILK YDGRFKDIF E++ A Y+ + + G
Sbjct: 223 NTDESITGFAHSCFQYALAKKWPLYLSTKNTILKRYDGRFKDIFEEIFVANYKKDYDSAG 282
Query: 243 IFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGKTV 302
I+YEHRLIDDMVA ++S G +VWACKNYDGDVQSD +AQG+GSLG+MTS+LM PDGKT+
Sbjct: 283 IWYEHRLIDDMVAQALKSSGEFVWACKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTI 342
Query: 303 EVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLEDVI 362
E EAAHGTVTRH+R++QKG TSTNP+ASIFAWTR L HRA++DNN L F LE V
Sbjct: 343 ESEAAHGTVTRHFREHQKGNATSTNPIASIFAWTRGLEHRAKLDNNPDLKHFCTTLEKVC 402
Query: 363 IATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQ 409
+ T+++G MT+DLA CI G KNV YLNT +F++A+S L A++
Sbjct: 403 VDTVDSGMMTKDLAGCIHGLKNVKPEHYLNTMDFLNAISVNLDKALK 449