BLASTP 2.2.17 [Aug-26-2007]
Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Reference for composition-based statistics:
Schäffer, Alejandro A., L. Aravind, Thomas L. Madden,
Schaffer, Alejandro A., L. Aravind, Thomas L. Madden,
Sergei Shavirin, John L. Spouge, Yuri I. Wolf,
Eugene V. Koonin, and Stephen F. Altschul (2001),
"Improving the accuracy of PSI-BLAST protein database searches with
composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005.
Query= YMR208W__[Saccharomyces_cerevisiae]
(443 letters)
Database: nr.pal
6,348,806 sequences; 2,166,943,470 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|6323864|ref|NP_013935.1| Mevalonate kinase, acts in the ... 810 0.0
gi|2804172|dbj|BAA24409.1| mevalonate kinase [Saccharomyces... 461 e-128
gi|50287417|ref|XP_446138.1| unnamed protein product [Candi... 378 e-103
gi|45190937|ref|NP_985191.1| AER335Wp [Ashbya gossypii ATCC... 340 2e-91
gi|50305147|ref|XP_452532.1| unnamed protein product [Kluyv... 327 1e-87
gi|68464835|ref|XP_723495.1| mevalonate kinase [Candida alb... 249 4e-64
gi|50424525|ref|XP_460851.1| hypothetical protein DEHA0F121... 244 7e-63
gi|149246950|ref|XP_001527900.1| hypothetical protein LELG_... 229 4e-58
gi|146414678|ref|XP_001483309.1| hypothetical protein PGUG_... 208 6e-52
gi|116206428|ref|XP_001229023.1| hypothetical protein CHGG_... 203 3e-50
gi|50546973|ref|XP_500956.1| hypothetical protein [Yarrowia... 198 6e-49
gi|85102580|ref|XP_961360.1| hypothetical protein NCU03633 ... 198 7e-49
gi|46123069|ref|XP_386088.1| hypothetical protein FG05912.1... 194 8e-48
gi|145257009|ref|XP_001401587.1| hypothetical protein An04g... 194 1e-47
gi|121706910|ref|XP_001271672.1| mevalonate kinase [Aspergi... 192 3e-47
gi|115398019|ref|XP_001214601.1| conserved hypothetical pro... 192 5e-47
gi|169773659|ref|XP_001821298.1| [Aspergillus oryzae] >gi|8... 190 2e-46
gi|67526823|ref|XP_661473.1| hypothetical protein AN3869.2 ... 189 4e-46
gi|39978123|ref|XP_370449.1| hypothetical protein MGG_06946... 186 2e-45
gi|119181177|ref|XP_001241830.1| hypothetical protein CIMG_... 186 3e-45
gi|70994538|ref|XP_752047.1| mevalonate kinase [Aspergillus... 181 1e-43
gi|119500972|ref|XP_001267243.1| mevalonate kinase [Neosart... 178 9e-43
gi|71022827|ref|XP_761643.1| hypothetical protein UM05496.1... 147 1e-33
gi|72125755|ref|XP_790690.1| PREDICTED: similar to Mevalona... 133 3e-29
gi|123227559|emb|CAM15186.1| novel protein similar to verte... 133 3e-29
gi|55925207|ref|NP_001007350.1| hypothetical protein LOC492... 132 6e-29
gi|62089024|dbj|BAD92959.1| mevalonate kinase variant [Homo... 131 8e-29
gi|126324791|ref|XP_001364115.1| PREDICTED: similar to meva... 131 1e-28
gi|450346|emb|CAA53059.1| unnamed protein product [Hepatiti... 131 1e-28
gi|4557769|ref|NP_000422.1| mevalonate kinase [Homo sapiens... 130 1e-28
gi|33303805|gb|AAQ02416.1| mevalonate kinase [synthetic con... 130 2e-28
gi|73995337|ref|XP_543435.2| PREDICTED: similar to Mevalona... 129 5e-28
gi|157113429|ref|XP_001657825.1| mevalonate kinase [Aedes a... 127 1e-27
gi|109098668|ref|XP_001105759.1| PREDICTED: mevalonate kina... 126 4e-27
gi|169859430|ref|XP_001836355.1| hypothetical protein CC1G_... 125 5e-27
gi|61555432|gb|AAX46713.1| mevalonate kinase [Bos taurus] 125 7e-27
gi|59857699|gb|AAX08684.1| mevalonate kinase [Bos taurus] 125 9e-27
gi|62751666|ref|NP_001015528.1| mevalonate kinase [Bos taur... 125 9e-27
gi|19113749|ref|NP_592837.1| mevalonate kinase Erg12 (predi... 122 7e-26
gi|109098672|ref|XP_001105689.1| PREDICTED: mevalonate kina... 122 7e-26
gi|47226511|emb|CAG08527.1| unnamed protein product [Tetrao... 122 7e-26
gi|58260880|ref|XP_567850.1| cystathionine beta-lyase [Cryp... 119 6e-25
gi|58260882|ref|XP_567851.1| cystathionine beta-lyase [Cryp... 118 8e-25
gi|16905216|gb|AAL31086.1|AC091749_15 putative mevalonate k... 115 5e-24
gi|115481534|ref|NP_001064360.1| Os10g0329300 [Oryza sativa... 115 5e-24
gi|66824057|ref|XP_645383.1| hypothetical protein DDBDRAFT_... 114 2e-23
gi|91084321|ref|XP_972334.1| PREDICTED: similar to mevalona... 113 2e-23
gi|5578718|gb|AAD45421.1|L77688_1 mevalonate kinase [Arabid... 108 6e-22
gi|15240936|ref|NP_198097.1| MK/MVK; mevalonate kinase [Ara... 108 1e-21
gi|78707210|ref|NP_001027412.1| CG33671 CG33671-PA [Drosoph... 106 3e-21
gi|74203980|dbj|BAE28997.1| unnamed protein product [Mus mu... 102 6e-20
gi|12963731|ref|NP_076045.1| mevalonate kinase [Mus musculu... 102 6e-20
gi|87240539|gb|ABD32397.1| Mevalonate and galactokinase [Me... 102 7e-20
gi|125531485|gb|EAY78050.1| hypothetical protein OsI_032009... 101 1e-19
gi|61555394|gb|AAX46707.1| mevalonate kinase [Bos taurus] 101 1e-19
gi|125574393|gb|EAZ15677.1| hypothetical protein OsJ_029886... 100 3e-19
gi|13592007|ref|NP_112325.1| mevalonate kinase [Rattus norv... 98 1e-18
gi|153792072|ref|NP_001093299.1| mevalonate kinase [Bombyx ... 96 5e-18
gi|125560302|gb|EAZ05750.1| hypothetical protein OsI_026982... 93 4e-17
gi|110748754|ref|XP_624545.2| PREDICTED: similar to Mevalon... 93 4e-17
gi|71993806|ref|NP_001022869.1| Y42G9A.4d [Caenorhabditis e... 91 1e-16
gi|71993800|ref|NP_001022868.1| Y42G9A.4c [Caenorhabditis e... 91 1e-16
gi|147801314|emb|CAN77024.1| hypothetical protein [Vitis vi... 90 3e-16
gi|71993795|ref|NP_001022867.1| Y42G9A.4b [Caenorhabditis e... 90 3e-16
gi|16417946|gb|AAL18925.1|AF429384_1 mevalonate kinase [Hev... 90 4e-16
gi|82898655|ref|XP_918559.1| PREDICTED: similar to mevalona... 89 9e-16
gi|57641409|ref|YP_183887.1| mevalonate kinase [Thermococcu... 88 1e-15
gi|18978009|ref|NP_579366.1| mevalonate kinase [Pyrococcus ... 84 2e-14
gi|119618276|gb|EAW97870.1| mevalonate kinase (mevalonic ac... 83 4e-14
gi|119719800|ref|YP_920295.1| mevalonate kinase [Thermofilu... 73 4e-11
gi|146185755|ref|XP_001032429.2| DnaJ domain containing pro... 71 2e-10
gi|47200914|emb|CAF88123.1| unnamed protein product [Tetrao... 67 3e-09
gi|159900828|ref|YP_001547075.1| mevalonate kinase [Herpeto... 66 4e-09
gi|14591399|ref|NP_143478.1| mevalonate kinase [Pyrococcus ... 65 8e-09
gi|14520757|ref|NP_126232.1| mevalonate kinase [Pyrococcus ... 65 1e-08
gi|108947727|gb|ABG24208.1| mevalonate kinase [Arnebia euch... 63 4e-08
gi|116753789|ref|YP_842907.1| mevalonate kinase [Methanosae... 62 8e-08
gi|72041321|ref|XP_793882.1| PREDICTED: similar to mevalona... 61 2e-07
gi|126465130|ref|YP_001040239.1| mevalonate kinase [Staphyl... 59 8e-07
gi|154342246|ref|XP_001567071.1| mevalonate kinase, putativ... 57 2e-06
gi|147921498|ref|YP_684687.1| mevalonate kinase [uncultured... 57 3e-06
gi|15897316|ref|NP_341921.1| Mevalonate kinase [Sulfolobus ... 56 5e-06
gi|71993790|ref|NP_001022866.1| Y42G9A.4a [Caenorhabditis e... 56 5e-06
gi|157776698|ref|XP_001666415.1| hypothetical protein CBG21... 56 6e-06
gi|123490584|ref|XP_001325649.1| mevalonate kinase family p... 55 8e-06
gi|72388266|ref|XP_844557.1| mevalonate kinase, putative [T... 55 8e-06
gi|124027753|ref|YP_001013073.1| Mevalonate kinase [Hyperth... 54 2e-05
gi|163846458|ref|YP_001634502.1| mevalonate kinase [Chlorof... 53 4e-05
gi|115377877|ref|ZP_01465063.1| mevalonate kinase [Stigmate... 53 4e-05
gi|146094774|ref|XP_001467381.1| mevalonate kinase [Leishma... 53 5e-05
gi|118098609|ref|XP_001231562.1| PREDICTED: hypothetical pr... 51 1e-04
gi|11499870|ref|NP_071114.1| mevalonate kinase (mvk) [Archa... 51 1e-04
gi|84489658|ref|YP_447890.1| putative mevalonate kinase [Me... 51 2e-04
gi|149063615|gb|EDM13938.1| mevalonate kinase, isoform CRA_... 51 2e-04
gi|71651924|ref|XP_814628.1| mevalonate kinase, putative [T... 51 2e-04
gi|149063616|gb|EDM13939.1| mevalonate kinase, isoform CRA_... 51 2e-04
gi|148687960|gb|EDL19907.1| mevalonate kinase, isoform CRA_... 50 3e-04
gi|71397724|ref|XP_802528.1| mevalonate kinase, putative [T... 50 3e-04
gi|148643499|ref|YP_001274012.1| mevalonate kinase [Methano... 50 4e-04
gi|156741717|ref|YP_001431846.1| mevalonate kinase [Roseifl... 49 7e-04
>gi|6323864|ref|NP_013935.1| Mevalonate kinase, acts in the biosynthesis of isoprenoids and
sterols, including ergosterol, from mevalonate; Erg12p
[Saccharomyces cerevisiae]
gi|125407|sp|P07277|KIME_YEAST Mevalonate kinase (MK) (MvK)
gi|3684|emb|CAA39359.1| mevalonate kinase [Saccharomyces cerevisiae]
gi|4287|emb|CAA29487.1| unnamed protein product [Saccharomyces cerevisiae]
gi|854460|emb|CAA89923.1| Rar1p [Saccharomyces cerevisiae]
Length = 443
Score = 810 bits (2092), Expect = 0.0, Method: Composition-based stats.
Identities = 406/443 (91%), Positives = 406/443 (91%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFN 60
MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFN
Sbjct: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFN 60
Query: 61 HKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLY 120
HKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLY
Sbjct: 61 HKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLY 120
Query: 121 MFVCLCPHAKNIKFSLKSTLPIXXXXXXXXXXXXXXXXXXXYLGGLIGSNDLEKLSENDK 180
MFVCLCPHAKNIKFSLKSTLPI YLGGLIGSNDLEKLSENDK
Sbjct: 121 MFVCLCPHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLIGSNDLEKLSENDK 180
Query: 181 HIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLDDFPAIPMI 240
HIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLDDFPAIPMI
Sbjct: 181 HIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLDDFPAIPMI 240
Query: 241 LTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSKCKGTDDEA 300
LTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSKCKGTDDEA
Sbjct: 241 LTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSKCKGTDDEA 300
Query: 301 VETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIXXXXXXXXXXXXXXXX 360
VETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRI
Sbjct: 301 VETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGAGGGGCSLT 360
Query: 361 XXRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLNKDLKIKSLVFQLFEN 420
RRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLNKDLKIKSLVFQLFEN
Sbjct: 361 LLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLNKDLKIKSLVFQLFEN 420
Query: 421 KTTTKQQIDDLLLPGNTNLPWTS 443
KTTTKQQIDDLLLPGNTNLPWTS
Sbjct: 421 KTTTKQQIDDLLLPGNTNLPWTS 443
>gi|2804172|dbj|BAA24409.1| mevalonate kinase [Saccharomyces cerevisiae]
Length = 246
Score = 461 bits (1187), Expect = e-128, Method: Composition-based stats.
Identities = 227/246 (92%), Positives = 227/246 (92%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFN 60
MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFN
Sbjct: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFN 60
Query: 61 HKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLY 120
HKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLY
Sbjct: 61 HKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLY 120
Query: 121 MFVCLCPHAKNIKFSLKSTLPIXXXXXXXXXXXXXXXXXXXYLGGLIGSNDLEKLSENDK 180
MFVCLCPHAKNIKFSLKSTLPI YLGGLIGSNDLEKLSENDK
Sbjct: 121 MFVCLCPHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLIGSNDLEKLSENDK 180
Query: 181 HIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLDDFPAIPMI 240
HIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLDDFPAIPMI
Sbjct: 181 HIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLDDFPAIPMI 240
Query: 241 LTYTRI 246
LTYTRI
Sbjct: 241 LTYTRI 246
>gi|50287417|ref|XP_446138.1| unnamed protein product [Candida glabrata]
gi|49525445|emb|CAG59062.1| unnamed protein product [Candida glabrata CBS 138]
Length = 430
Score = 378 bits (970), Expect = e-103, Method: Composition-based stats.
Identities = 213/441 (48%), Positives = 279/441 (63%), Gaps = 35/441 (7%)
Query: 3 LPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISE--SSAPDTIELDFPDISFN 60
LPFL SAPGKVI+FGEHSAVYN+PAVAASVS+LRTYLL+S S+A D+IEL FPDI F+
Sbjct: 7 LPFLVSAPGKVILFGEHSAVYNEPAVAASVSSLRTYLLVSPAGSNAEDSIELSFPDIGFD 66
Query: 61 HKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLY 120
H W + + + + L A++ T L++ELV LL+ +L L ES HYHAAFCFLY
Sbjct: 67 HVWKRKELEPVLRE---TALLQAAREDTKNLNEELVGLLNVILEPLKESLHYHAAFCFLY 123
Query: 121 MFVCLCPHAKNIKFSLKSTLPIXXXXXXXXXXXXXXXXXXXYLGGLIGSNDLEKLSENDK 180
+F LCP A NIKFS+KSTLPI LGG + + E LS DK
Sbjct: 124 LFCTLCPSATNIKFSVKSTLPIGAGLGSSAAISVSLAMAMLRLGGKLVTG--ESLSGEDK 181
Query: 181 HIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLDDFP--AIP 238
++N+WAFIGEKCIHGTPSGIDNAVATYGNA+LF++ + T +F+FLD F IP
Sbjct: 182 ALINEWAFIGEKCIHGTPSGIDNAVATYGNAVLFKRSAD----GTTDFEFLDKFHELKIP 237
Query: 239 MILTYTRIPRSTKDLVARVRVLVTEKFPEVMKP-ILDAMGECALQGLEIMTKLSKCKGTD 297
M+LTYTRIPRSTK LV+ VR L + K+P+V++ ++ AMGE AL+ ++I+
Sbjct: 238 MVLTYTRIPRSTKVLVSSVRDL-SNKYPKVIQDHVIKAMGELALESVDIL---------- 286
Query: 298 DEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIXXXXXXXXXXXXX 357
+ + N+ YE+LL+L+ INHGLLV+IGVSHPGLE+I+NLS I
Sbjct: 287 NSGIGGNDSNYERLLDLVNINHGLLVAIGVSHPGLEIIRNLSITNSIGATKLTGAGGGGC 346
Query: 358 XXXXXRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCL---LSAKNLNKDLKIKSLV 414
+D+ Q ++D FK++L Y +F ++LGG G C+ L A+ N LV
Sbjct: 347 AFTVLNKDVPQTEVDKFKEELSKKHGYLSFTSELGGAGSCMTPTLVAEQYN-------LV 399
Query: 415 FQLFENKTTTKQQIDDLLLPG 435
LFEN K+++D LLP
Sbjct: 400 APLFENTENNKEELDKTLLPA 420
>gi|45190937|ref|NP_985191.1| AER335Wp [Ashbya gossypii ATCC 10895]
gi|44984005|gb|AAS53015.1| AER335Wp [Ashbya gossypii ATCC 10895]
Length = 428
Score = 340 bits (871), Expect = 2e-91, Method: Composition-based stats.
Identities = 182/440 (41%), Positives = 257/440 (58%), Gaps = 29/440 (6%)
Query: 3 LPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFNHK 62
LPF+TSAPGKVIIFGEHSAVYNKPA+AASVS+LRTYL + + D + ++FPDI F +
Sbjct: 14 LPFITSAPGKVIIFGEHSAVYNKPAIAASVSSLRTYLFVEADAESDAVRMEFPDIGFQYS 73
Query: 63 WSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLYMF 122
W A+ + V ++ L E+++ +D LL L + HAA CFLY++
Sbjct: 74 WKHEALTAVPREAVVRAFCSRE------LDAEVLAHVDRLLMGLEGALARHAALCFLYIY 127
Query: 123 VCLCPHAKNIKFSLKSTLPIXXXXXXXXXXXXXXXXXXXYLGGLIGSNDLEKLSENDKHI 182
CLC + ++F++KSTLPI LGG + L++ +
Sbjct: 128 TCLCREVQGVRFTVKSTLPIGAGLGSSASIAVCLALAMGRLGGHVQCES-GALTKEQQDF 186
Query: 183 VNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLDDFPAIPMILT 242
VN+WA +GE+CIHGTPSGIDNAVATYG+A+LF++ T F L DFP +PMILT
Sbjct: 187 VNRWALVGEQCIHGTPSGIDNAVATYGDAVLFQRQPDGST----KFDHLSDFPQMPMILT 242
Query: 243 YTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSKCKGTDDEAVE 302
T++P+STK LVA V LV E+ P + PIL+ M + Q E++ L +
Sbjct: 243 NTKVPKSTKVLVANVGKLV-EQEPLITAPILNTMAQVVTQAHELLPLL-----------Q 290
Query: 303 TNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIXXXXXXXXXXXXXXXXXX 362
++ +Y +LL+L+RINHGLLV++GVSHP LE ++ L D L I
Sbjct: 291 GDDTVYTRLLQLVRINHGLLVALGVSHPSLEHVRALCDTLGIGATKLTGAGGGGCALTLL 350
Query: 363 RRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLNKDL-KIKSLVFQLFENK 421
+RD+ E ++ F+K L D YE+F T LGG GCCL +++ + L +IK+L FQ +
Sbjct: 351 KRDVEDELVEQFRKTLLDKHGYESFTTGLGGVGCCLATSQTIRPHLDRIKTL-FQ----E 405
Query: 422 TTTKQQIDDLLLPGNTNLPW 441
T +QQ+ + LLPG + + W
Sbjct: 406 DTPQQQLAEALLPGASPIDW 425
>gi|50305147|ref|XP_452532.1| unnamed protein product [Kluyveromyces lactis]
gi|49641665|emb|CAH01383.1| unnamed protein product [Kluyveromyces lactis NRRL Y-1140]
Length = 419
Score = 327 bits (838), Expect = 1e-87, Method: Composition-based stats.
Identities = 193/441 (43%), Positives = 263/441 (59%), Gaps = 32/441 (7%)
Query: 4 PFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFNHKW 63
PF+ SAPGKVIIFGEHSAV+NK A+AASVS+LRTYLLI +S D +ELDFPDI+++ KW
Sbjct: 10 PFIVSAPGKVIIFGEHSAVFNKNAIAASVSSLRTYLLIEQSKDGDGVELDFPDINYDSKW 69
Query: 64 SINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLYMFV 123
S + I + V K L +L L+ LL L +S +Y+AA FLY+++
Sbjct: 70 STEELKTIDSEVV------KQAAGLKHLCPKLKEQLNLLLEGLKDSLNYYAALSFLYLYL 123
Query: 124 CLCPHAKNIKFSLKSTLPIXXXXXXXXXXXXXXXXXXXYLGGLIGSNDLEKLSENDKHIV 183
LCP+ K +KF++KSTLPI +GG I + + +S+ +K +
Sbjct: 124 SLCPNVKGLKFTVKSTLPIGAGLGSSASISVCLALAMARMGGHISCD--KSISQEEKEFI 181
Query: 184 NQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLDDFPAIPMILTY 243
N WAFIGE CIHGTPSGIDNAVATYGNA+ F++ T F + +FP +PM+LT
Sbjct: 182 NHWAFIGECCIHGTPSGIDNAVATYGNAVKFKRQEDGST----KFDQISNFPQLPMVLTN 237
Query: 244 TRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSKCKGTDDEAVET 303
TRI RSTK LV+ V LV K P + +PIL+AM + AL+G E+++ +SK
Sbjct: 238 TRIKRSTKILVSGVGDLVNRK-PLITEPILEAMNQVALRGSELLSDISK----------- 285
Query: 304 NNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIXXXXXXXXXXXXXXXXXXR 363
+ Y++LLELIRINHGLLV+IGVSHPGLE+IK LSD+L+I
Sbjct: 286 -DIHYDELLELIRINHGLLVAIGVSHPGLEVIKQLSDELKIGQTKLTGAGGGGCAFTLLN 344
Query: 364 RDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLNKDLKIKSLVFQLFENKTT 423
+D+ + F +KL ++ Y+ FET LGG GCC + KN + +K L +
Sbjct: 345 KDVDHSSVRKFHEKLHSNYGYQIFETGLGGVGCCFVDLKNEQYE-SLKHLFID-----SA 398
Query: 424 TKQQIDDLLLPG-NTNLPWTS 443
T Q++ LLP + +L WT+
Sbjct: 399 TVQEVSLALLPSPDGSLTWTA 419
>gi|68464835|ref|XP_723495.1| mevalonate kinase [Candida albicans SC5314]
gi|68465212|ref|XP_723305.1| mevalonate kinase [Candida albicans SC5314]
gi|46445332|gb|EAL04601.1| hypothetical protein CaO19.12272 [Candida albicans SC5314]
gi|46445529|gb|EAL04797.1| hypothetical protein CaO19.4809 [Candida albicans SC5314]
Length = 431
Score = 249 bits (635), Expect = 4e-64, Method: Composition-based stats.
Identities = 158/419 (37%), Positives = 219/419 (52%), Gaps = 33/419 (7%)
Query: 3 LPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFNHK 62
LPF+ APGKVIIFGEH+AVY KPA+AA++S LR YLL+S SS +TI L FPDI +H
Sbjct: 4 LPFIVGAPGKVIIFGEHAAVYGKPAIAAALS-LRCYLLVSPSSDSNTIRLQFPDIKLDHS 62
Query: 63 WSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLYMF 122
W+I D + A Q L E+V L L HY+A FCFLY+
Sbjct: 63 WNIKDLPWEEIKPYLTYDSANKPQIPSELVPEIVDKLSSFLNGFDNKMHYYACFCFLYLL 122
Query: 123 VCLC-PHAKNIKFSLKSTLPIXXXXXXXXXXXXXXXXXXXYLGGLIGSNDLEKLSENDK- 180
+ LC + F ++STLPI +GG I L ENDK
Sbjct: 123 MNLCDSKVSGMNFIVRSTLPIGAGLGSSASTSVCLSSALALMGGWINK---PSLHENDKL 179
Query: 181 --------HIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDS--HNGTINTNNFKF 230
+++W+ IGEKC HG PSGIDNAVAT+G A++F++ S +I TN
Sbjct: 180 DTADIPDLEFIDKWSLIGEKCFHGNPSGIDNAVATFGGAVMFQRTSTPEQPSIRTN---- 235
Query: 231 LDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKL 290
+ +FPAI ++LT T++P+ST DLVA V L E F + IL A+ + + ++M +
Sbjct: 236 MRNFPAIKLLLTNTKVPKSTADLVAGVGRLNAE-FNSISTSILTAIEHLSQEAYKVM--M 292
Query: 291 SKCKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIXXXXXX 350
+ G ++ V L +L+ INHGLLV++GVSHP LE +K + D RI
Sbjct: 293 NPMFGKEETNV---------LRKLVNINHGLLVALGVSHPALETVKIIGDKHRIGATKLT 343
Query: 351 XXXXXXXXXXXXRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLNKDLK 409
D+ + I + K+ +D YE+FET LGG G +L ++L+ K
Sbjct: 344 GAGGGGCAITLVNDDVEESVIHNAIKEFEDS-GYESFETSLGGKGVGILFHEDLDDATK 401
>gi|50424525|ref|XP_460851.1| hypothetical protein DEHA0F12188g [Debaryomyces hansenii CBS767]
gi|49656520|emb|CAG89196.1| unnamed protein product [Debaryomyces hansenii CBS767]
Length = 433
Score = 244 bits (624), Expect = 7e-63, Method: Composition-based stats.
Identities = 156/414 (37%), Positives = 213/414 (51%), Gaps = 30/414 (7%)
Query: 4 PFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFNHKW 63
PFL SAPGKVII+GEHSAVY KPA+AA++S LR YLL++ + I LDFPDI +H W
Sbjct: 5 PFLVSAPGKVIIYGEHSAVYGKPAIAAALS-LRAYLLVTPCEDVNDIRLDFPDIGLSHSW 63
Query: 64 SINDFNAITEDQVNSQKLAKAQQA-TDGLSQELVSLLDPLLAQLSESFHYHAAFCFLYMF 122
N N ED + T+ L E+V LL +LA + HY A CFLY++
Sbjct: 64 --NKENIPWEDIRKFVTFKDEKPVVTEELVPEIVDLLSTVLADVESKLHYTACLCFLYLY 121
Query: 123 VCLC-PHAKNIKFSLKSTLPIXXXXXXXXXXXXXXXXXXXYLGGLIG------SNDLEKL 175
L ++F +KSTLPI LG + + + K
Sbjct: 122 ANLSNKDVPGMRFIVKSTLPIGAGLGSSACTAVCLASALARLGKHVSAACHTSTEKVYKK 181
Query: 176 SENDKHIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDS--HNGTINTNNFKFLDD 233
+D ++ W+ +GEKC HG PSGIDNAVATYG A++F++ + ++ T + +
Sbjct: 182 ENSDLDFIDSWSLMGEKCFHGNPSGIDNAVATYGGAVMFQRTTIPSKPSVRTT----MRN 237
Query: 234 FPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSKC 293
FP I +IL T++PRST LV V V +P+ ILDAM + +IM + S
Sbjct: 238 FPPIKLILINTKVPRSTAALVGNV-AQVNRTYPKCAGSILDAMEHLVFEAYQIMIRPSFG 296
Query: 294 KGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIXXXXXXXXX 353
K D QL EL+ INHGLLV++GVSHP LE IK + D I
Sbjct: 297 KEEKD-----------QLRELVNINHGLLVALGVSHPALEKIKIIGDTHGIGSTKLTGAG 345
Query: 354 XXXXXXXXXRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLNKD 407
D+ +E I K+ +++ YETFET LGG G LS ++++KD
Sbjct: 346 GGGCAISLVHDDVEEEVIQKAIKEFENE-GYETFETSLGGKGVGSLSLEDVDKD 398
>gi|149246950|ref|XP_001527900.1| hypothetical protein LELG_00420 [Lodderomyces elongisporus NRRL
YB-4239]
gi|146447854|gb|EDK42242.1| hypothetical protein LELG_00420 [Lodderomyces elongisporus NRRL
YB-4239]
Length = 439
Score = 229 bits (583), Expect = 4e-58, Method: Composition-based stats.
Identities = 148/412 (35%), Positives = 220/412 (53%), Gaps = 36/412 (8%)
Query: 2 SLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSA-PDTIELDFPDISFN 60
SL F+ SAPGKVIIFGEH+AVY KPA+AA++S LR +LL++ S+ + + L FPDI +
Sbjct: 8 SLKFVVSAPGKVIIFGEHAAVYGKPAIAAALS-LRCFLLVTPSTGDSNMVRLKFPDIGLD 66
Query: 61 HKWSINDFNAIT-EDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFL 119
H W I+ T + +V + K Q + L E+V L PLL L ++ HY A FCFL
Sbjct: 67 HSWDISSIPWETIKAKVKADSNGKPQPPAE-LDPEIVDSLSPLLRNLDDNVHYIACFCFL 125
Query: 120 YMFVCLCPH-AKNIKFSLKSTLPIXXXXXXXXXXXXXXXXXXXYLGGLIGSNDLEKLSEN 178
Y++ LC + F ++STLPI LG I KLS +
Sbjct: 126 YLYTNLCSQDLQGYTFVVRSTLPIGAGLGSSASTAVCLSAALSKLGNWIKD---PKLSNH 182
Query: 179 DK---------HIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEK--DSHNGTINTNN 227
D ++ W+ IGEKC HG PSGIDNAVAT+G A+ +++ +S ++ ++
Sbjct: 183 DHVLESEIPELDFIDNWSLIGEKCFHGNPSGIDNAVATHGGAVKYQRILNSTKSSLRSS- 241
Query: 228 FKFLDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIM 287
+ DFP I ++LT T++P+ST LVA V L T++FP++ PIL+A+ + Q E+M
Sbjct: 242 ---IRDFPPIKLLLTNTKVPKSTAKLVAGVGEL-TKEFPDITNPILNAVEFISEQAYEVM 297
Query: 288 TKLSKCKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIXXX 347
+ + L +L+ +NHGLLV++GVSHP LE +K +SD +
Sbjct: 298 -----------HLPQFGKQETATLRKLVNMNHGLLVALGVSHPALETVKIISDKYNLGAT 346
Query: 348 XXXXXXXXXXXXXXXRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLL 399
I + I + K+ +++ +E+FET LGG G +L
Sbjct: 347 KLTGAGGGGCAITLVDESIDKSVIHNAMKEYENE-GFESFETSLGGKGVGML 397
>gi|146414678|ref|XP_001483309.1| hypothetical protein PGUG_04038 [Pichia guilliermondii ATCC 6260]
gi|146391782|gb|EDK39940.1| hypothetical protein PGUG_04038 [Pichia guilliermondii ATCC 6260]
Length = 423
Score = 208 bits (530), Expect = 6e-52, Method: Composition-based stats.
Identities = 142/414 (34%), Positives = 212/414 (51%), Gaps = 40/414 (9%)
Query: 4 PFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFNHKW 63
PF SAPGKVI+FGEH+AVY KPA+AA++S L + D++ L+FPDI +H W
Sbjct: 3 PFYISAPGKVILFGEHAAVYGKPALAAALSLRAYLLATETND--DSLRLEFPDIQLSHSW 60
Query: 64 SINDF---NAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLY 120
+++ NA Q + ++ TD L+ E+++L+ L + + HY CFLY
Sbjct: 61 KLSELPWENA----QAHIERKNGKPVPTDELNPEVINLIGEFLGDIESTAHYTTCLCFLY 116
Query: 121 MFVCLC-PHAKNIKFSLKSTLPIXXXXXXXXXXXXXXXXXXXYLGGLIGSNDLEK----L 175
+++ LC P + F ++STLPI LGG I S +
Sbjct: 117 LYLHLCDPLVASRSFCIRSTLPIGAGLGSSASAAVCLTSTLALLGGHIRSPQYSEKQRVS 176
Query: 176 SEN-DKHIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEK--DSHNGTINTNNFKFLD 232
SEN D ++ W+ +GEKC HG PSGIDNAVAT+G A+++++ ++ T +
Sbjct: 177 SENPDAEFIDSWSLMGEKCFHGNPSGIDNAVATHGGAVMYQRMLAPDMPSVRTA----MR 232
Query: 233 DFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSK 292
+FP + ++LT T++PRST +LV V V + P+ ILDA+ A IM+ S
Sbjct: 233 NFPPLKLLLTNTKVPRSTAELVGGV-AKVNTRHPKTAGSILDAVSHLATDAYHIMSHPSF 291
Query: 293 CKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIXXXXXXXX 352
E E L +L+ INHGLLV++GVSHP LE IK + D RI
Sbjct: 292 AA-----------EDRESLRQLVNINHGLLVALGVSHPALEKIKMIGDTNRIGATKLTGA 340
Query: 353 XXXXXXXXXXRRDITQEQIDSFKKKLQDDFS---YETFETDLGGTGCCLLSAKN 403
+++ E ++ K++++F+ +ETFE LGG G L N
Sbjct: 341 GGGGCAITLLNDEVSHEVLE----KVENEFTQEGFETFEATLGGKGVGALFCDN 390
>gi|116206428|ref|XP_001229023.1| hypothetical protein CHGG_02507 [Chaetomium globosum CBS 148.51]
gi|88183104|gb|EAQ90572.1| hypothetical protein CHGG_02507 [Chaetomium globosum CBS 148.51]
Length = 532
Score = 203 bits (516), Expect = 3e-50, Method: Composition-based stats.
Identities = 140/412 (33%), Positives = 216/412 (52%), Gaps = 30/412 (7%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISE-SSAPDTIELDFPDISF 59
M F+ SAPGKVI+FGEHS V+ K A+AA++S LR+YLL++ S + T+ L FPDI F
Sbjct: 82 MMPAFMVSAPGKVIVFGEHSVVHGKAAIAAAIS-LRSYLLVTTLSKSKRTVTLKFPDIDF 140
Query: 60 NHKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLS-------ESFHY 112
+H W+I++ T Q + +K + L ELV+ + P LA +S H
Sbjct: 141 DHCWNIDELPWATFQQPSKKKYYYS--LVTELDPELVAAIQPFLANVSPDKPAGIRKVHQ 198
Query: 113 HAAFCFLYMFVCLCPHA-KNIKFSLKSTLPIXXXXXXXXXXXX-XXXXXXXYLGGLIGSN 170
++A FLYMF+ L + +++L+ST+PI L L G +
Sbjct: 199 NSAGSFLYMFLSLGSQSFPGCQYTLRSTIPIGAGLGSSATIAVCMSAALLLQLRTLAGPH 258
Query: 171 DLEKLSENDKHI--VNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNF 228
+ E I +N+WA++ E IHG PSG+DN VAT G A++F++ + +
Sbjct: 259 PDQPADEARMQIERINRWAYVYEMFIHGNPSGVDNTVATQGKAVVFQRTDYG---KPPSV 315
Query: 229 KFLDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMT 288
+ L DFP +P++L TR+P+ST VA+V L P ++ ILDAM + A E++T
Sbjct: 316 RPLWDFPELPLLLVDTRVPKSTAHEVAKVGKL-KNTHPVLVGSILDAMDKVADASAEVLT 374
Query: 289 KLSKCKGTDDEAVETNNEL-YEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIXXX 347
+E +T +E ++ EL+ +NHGLLVS+GVSHP LE ++ L D I
Sbjct: 375 ---------EEGFDTQSEASLARVGELMTVNHGLLVSLGVSHPRLERVRELVDHEGIGWT 425
Query: 348 XXXXXXXXXXXXXXXRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLL 399
+ + ++++ + +L D+ +E FET LGG G +L
Sbjct: 426 KLTGAGGGGCCITLLKPGVERKKLRKLQAQL-DEEGFEKFETTLGGDGVGVL 476
>gi|50546973|ref|XP_500956.1| hypothetical protein [Yarrowia lipolytica]
gi|49646822|emb|CAG83209.1| unnamed protein product [Yarrowia lipolytica CLIB122]
Length = 449
Score = 198 bits (504), Expect = 6e-49, Method: Composition-based stats.
Identities = 132/372 (35%), Positives = 203/372 (54%), Gaps = 50/372 (13%)
Query: 3 LPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIE-LDFPDISFNH 61
+ ++ SAPGKVI+FGEH+AV+ KPA+AA++ LRTYLL+ +++ L+FPDI N
Sbjct: 1 MDYIISAPGKVILFGEHAAVFGKPAIAAAID-LRTYLLVETTTSDTPTVTLEFPDIHLNF 59
Query: 62 KWSINDFNAITE----DQVN-SQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAF 116
K ++ ++T D +N S + D LS L L +P L ++ ++ A
Sbjct: 60 KVQVDKLASLTAQTKADHLNWSTPKTLDKHIFDSLSS-LALLEEPGLTKVQQA----AVV 114
Query: 117 CFLYMFVCLCPHA---KNIKFSLKSTLPIXXXXXXXXXXXXXXXXXXXYLGGLIG---SN 170
FLY+++ LCP + + + ++STLPI L G + +
Sbjct: 115 SFLYLYIHLCPPSVCEDSSNWVVRSTLPIGAGLGSSASICVCLAAGLLVLNGQLSIDQAR 174
Query: 171 DLEKLSENDKHIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKF 230
D + L+E +V+ W+F+GE CIHG PSGIDNAVAT G ALLF++ NN
Sbjct: 175 DFKSLTEKQLSLVDDWSFVGEMCIHGNPSGIDNAVATQGGALLFQR--------PNNRVP 226
Query: 231 LDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKL 290
L D P + ++LT T+ PRST DLV V VL T++F +M PI+ ++GE + Q +EI+++
Sbjct: 227 LVDIPEMKLLLTNTKHPRSTADLVGGVGVL-TKEFGSIMDPIMTSVGEISNQAMEIISRG 285
Query: 291 SK----------------------CKGTDDEA-VETNNELYEQLLELIRINHGLLVSIGV 327
K C +D A ++ ++ ++ L+RINHGLL+++GV
Sbjct: 286 KKMVDQSNLEIEQGILPQPTSEDACNVMEDGATLQKLRDIGSEMQHLVRINHGLLIAMGV 345
Query: 328 SHPGLELIKNLS 339
SHP LE+I+ S
Sbjct: 346 SHPKLEIIRTAS 357
>gi|85102580|ref|XP_961360.1| hypothetical protein NCU03633 [Neurospora crassa OR74A]
gi|12718384|emb|CAC28692.1| related to MEVALONATE KINASE [Neurospora crassa]
gi|28922904|gb|EAA32124.1| hypothetical protein NCU03633 [Neurospora crassa OR74A]
Length = 528
Score = 198 bits (503), Expect = 7e-49, Method: Composition-based stats.
Identities = 137/407 (33%), Positives = 213/407 (52%), Gaps = 28/407 (6%)
Query: 5 FLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISE-SSAPDTIELDFPDISFNHKW 63
F+ SAPGKVI+FGEH+ V+ K A+AA++S LR+YLL++ S + T+ L FPDI FNH W
Sbjct: 80 FMVSAPGKVIVFGEHAVVHGKAAIAAAIS-LRSYLLVNTLSKSKRTVTLKFPDIDFNHSW 138
Query: 64 SINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLS-------ESFHYHAAF 116
+I++ Q +K + + QELV + P LA +S H ++A
Sbjct: 139 NIDELPWKIFQQPGKKKYYYS--LVTEIDQELVDAVQPFLADVSIDKPADIRKVHQNSAG 196
Query: 117 CFLYMFVCLCPHA-KNIKFSLKSTLPIXXXXXXXXXXXX-XXXXXXXYLGGLIGSNDLEK 174
FLYMF+ L + +++L+ST+PI L L G + +
Sbjct: 197 SFLYMFLSLGSQSFPGCQYTLRSTIPIGAGLGSSATIAVCLSAALLLQLRTLSGPHPDQP 256
Query: 175 LSENDKHI--VNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLD 232
E I +N+WAF+ E IHG PSG+DN V+T G A++F++ +N + + L
Sbjct: 257 PEEARLQIERINRWAFVYEMFIHGNPSGVDNTVSTQGKAVVFQRTDYN---QPPSVRPLW 313
Query: 233 DFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSK 292
DFP +P++L TR +ST VA+V L +K P+++ IL A+ + +++ + +
Sbjct: 314 DFPKLPLLLVDTRTAKSTAHEVAKVATL-KKKHPQLVGTILTAIDQVTQSSAQLIEE--Q 370
Query: 293 CKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIXXXXXXXX 352
T+DE E ++ E++ INHGLLVS+GVSHP LE ++ L D I
Sbjct: 371 GFNTEDE------ESLSKVGEMMTINHGLLVSLGVSHPRLERVRELVDHEGIGWTKLTGA 424
Query: 353 XXXXXXXXXXRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLL 399
R + +E++D +++L D+ Y FET LG G +L
Sbjct: 425 GGGGCSITLLRPGVPREKLDKLEQRL-DEEGYSKFETTLGSDGVGVL 470
>gi|46123069|ref|XP_386088.1| hypothetical protein FG05912.1 [Gibberella zeae PH-1]
Length = 508
Score = 194 bits (494), Expect = 8e-48, Method: Composition-based stats.
Identities = 139/411 (33%), Positives = 214/411 (52%), Gaps = 28/411 (6%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISE-SSAPDTIELDFPDISF 59
M+ PF+ SAPGKVI+FGEHS V+ K A+AA++S LR+YL ++ S + T+ L F DI
Sbjct: 57 MAPPFMVSAPGKVIVFGEHSVVHGKAAIAAAIS-LRSYLHVTTLSKSKRTVSLRFADIGL 115
Query: 60 NHKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSES-------FHY 112
H W+I D Q S+K + T+ L +LV+ + P + +S + H+
Sbjct: 116 VHTWNIEDL-PWEAFQQPSKKKSYYSLVTE-LDPDLVAAIQPHIEVVSPNHPEEIRRVHH 173
Query: 113 HAAFCFLYMFVCL-CPHAKNIKFSLKSTLPIXXXXXXXXXXXX-XXXXXXXYLGGLIGSN 170
+ FLY+F+ L P ++L+ST+PI L L G +
Sbjct: 174 SSVSAFLYLFLSLGSPSFPPCLYTLRSTIPIGAGLGSSASVSVCLASALLLQLRTLSGPH 233
Query: 171 DLEKLSENDKHI--VNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNF 228
+ E + +N+WAF+ E CIHG PSG+DN VAT G A++F++ ++ N
Sbjct: 234 PDQPADEARLQVERINRWAFVSEMCIHGNPSGVDNTVATQGKAVVFQRTDYS---KPPNV 290
Query: 229 KFLDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMT 288
+ L DFP +P++L TR +ST VA+V L + P+++ ILDAM + E++
Sbjct: 291 RPLWDFPELPLLLVDTRQAKSTAHEVAKVAKL-KQTHPKLVNSILDAMDKVTDAASELIE 349
Query: 289 KLSKCKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIXXXX 348
+ S D+ +VE ++ EL+ INHGLLVS+GVSHP LE ++ L D I
Sbjct: 350 ETS----FDNGSVED----LSKVGELMTINHGLLVSLGVSHPRLERVRELVDHEGIGWTK 401
Query: 349 XXXXXXXXXXXXXXRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLL 399
R D+ E++ +++L+ + +Y FET LGG G +L
Sbjct: 402 LTGAGGGGCSITLLRPDVPAEKLQKLEERLETE-NYAKFETTLGGDGIGVL 451
>gi|145257009|ref|XP_001401587.1| hypothetical protein An04g02190 [Aspergillus niger]
gi|134058497|emb|CAL00706.1| unnamed protein product [Aspergillus niger]
Length = 448
Score = 194 bits (493), Expect = 1e-47, Method: Composition-based stats.
Identities = 135/411 (32%), Positives = 209/411 (50%), Gaps = 28/411 (6%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISE-SSAPDTIELDFPDISF 59
M+ PF+ SAPGKVI+FGEH+ V+ K A+AA++S LR+Y L++ S + TI L+ D+ F
Sbjct: 1 MAPPFMVSAPGKVIVFGEHAVVHGKAAMAAAIS-LRSYFLVTTLSKSQRTITLNLRDMDF 59
Query: 60 NHKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLS-------ESFHY 112
NH W+I+D Q + +K L +EL L P + +S H
Sbjct: 60 NHTWNIDDLPWDFFKQPSKKKY--YYDLVTSLDEELYDSLKPCVEDISPKAPEEIRKKHK 117
Query: 113 HAAFCFLYMFVCL-CPHAKNIKFSLKSTLPIXXXXXXXXXX-XXXXXXXXXYLGGLIGSN 170
+A FLY+F L P ++L+ST+P+ + L G +
Sbjct: 118 GSALAFLYLFCSLGSPQHPGAIYTLRSTIPMGAGLGSSASVCTCFSAALLLQIRTLAGPH 177
Query: 171 DLEKLSENDKHI--VNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNF 228
D + E + I +N+WAF+GE CIHG PSG+DN V+T G A++F ++ ++
Sbjct: 178 DDQPPDEAELQIERINRWAFVGELCIHGNPSGVDNTVSTGGKAVIFRREDYS---KPPKV 234
Query: 229 KFLDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMT 288
L +FP +P++L TR RST VA+V L E P V + ILDA+ + + +
Sbjct: 235 IPLPNFPELPLLLVDTRQSRSTAVEVAKVGKLKKEH-PLVTESILDAIDKVTV------S 287
Query: 289 KLSKCKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIXXXX 348
S +G + ++++ E E + L+R+NHG LVS+GVSHP LE I+ L D I
Sbjct: 288 AQSAIQGVEGDSID--KETLEHIGTLVRVNHGFLVSLGVSHPRLERIRELVDFANIGWTK 345
Query: 349 XXXXXXXXXXXXXXRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLL 399
R D + + + ++KL + ++ +ET LGG G +L
Sbjct: 346 LTGAGGGGCAITLLRPDASVDALRELERKLAAE-NFSKYETTLGGDGIGVL 395
>gi|121706910|ref|XP_001271672.1| mevalonate kinase [Aspergillus clavatus NRRL 1]
gi|119399820|gb|EAW10246.1| mevalonate kinase [Aspergillus clavatus NRRL 1]
Length = 536
Score = 192 bits (489), Expect = 3e-47, Method: Composition-based stats.
Identities = 134/411 (32%), Positives = 205/411 (49%), Gaps = 28/411 (6%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISE-SSAPDTIELDFPDISF 59
M+ F+ SAPGKVI++GEH+ V+ K A+AA++S LR+YLL++ S + T+ ++F DI
Sbjct: 85 MAPAFMVSAPGKVIVYGEHAVVHGKAAMAAAIS-LRSYLLVTTLSKSQRTVTMNFRDIGL 143
Query: 60 NHKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLS-------ESFHY 112
+H W+I+D + +K L ELV + P + +S H
Sbjct: 144 DHTWNIDDLPWDVFHHPSKKKF--YYNLVTSLDPELVDAIQPHVDAVSPDKPEDVRKIHR 201
Query: 113 HAAFCFLYMFVCL-CPHAKNIKFSLKSTLPIXXXXXXXXXX-XXXXXXXXXYLGGLIGSN 170
+A FLY+F+ L P ++L+ST+PI + L G +
Sbjct: 202 RSASAFLYLFLSLGSPQTPGAIYTLRSTIPIGAGLGSSASVCVCLSAALLLQIRTLAGPH 261
Query: 171 DLEKLSENDKHI--VNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNF 228
+ E + I +N+WAF+GE C HG PSG+DN V+ G A++F ++ +
Sbjct: 262 PDQPPDEAETQIERINRWAFVGEMCTHGNPSGVDNTVSAGGKAVIFRREDYT---KPPTV 318
Query: 229 KFLDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMT 288
L +FP +P++L TR RST VA+V L + P V + ILDA+ + L E +
Sbjct: 319 IPLPNFPELPLLLVDTRQARSTAAEVAKVGKL-KDDHPVVTEAILDAIDKVTLAAQEAIQ 377
Query: 289 KLSKCKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIXXXX 348
++ KG + ++ E L LIRINHG LVS+GVSHP LE I+ L D I
Sbjct: 378 DINS-KG-------VSAQILEHLGTLIRINHGFLVSLGVSHPRLERIRELVDYANIGWTK 429
Query: 349 XXXXXXXXXXXXXXRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLL 399
R D+ +E + ++KL + +E +ET LGG G +L
Sbjct: 430 LTGAGGGGCAITVLRPDVKEEAVRDLEQKLSVE-GFEKYETTLGGDGIGVL 479
>gi|115398019|ref|XP_001214601.1| conserved hypothetical protein [Aspergillus terreus NIH2624]
gi|114192792|gb|EAU34492.1| conserved hypothetical protein [Aspergillus terreus NIH2624]
Length = 541
Score = 192 bits (487), Expect = 5e-47, Method: Composition-based stats.
Identities = 135/407 (33%), Positives = 201/407 (49%), Gaps = 28/407 (6%)
Query: 5 FLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISE-SSAPDTIELDFPDISFNHKW 63
F+ SAPGKVI+FGEH+ V+ K A+AA++S LR+YLL++ + + T+ L+F DI H W
Sbjct: 96 FMVSAPGKVIVFGEHAVVHGKAAMAAAIS-LRSYLLVTTLTKSQRTVTLNFRDIGLAHTW 154
Query: 64 SINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLS-------ESFHYHAAF 116
+I+D Q +K L ELV + P + Q+S H +A
Sbjct: 155 NIDDLPWDVFHQPAKKKY--YYDLVTSLDPELVDAIQPYVDQVSPDLPEDQRKIHRRSAS 212
Query: 117 CFLYMFVCL-CPHAKNIKFSLKSTLPIXXXXXXXXXX-XXXXXXXXXYLGGLIGSNDLEK 174
FLY+ + L P ++L+ST+PI + L G + +
Sbjct: 213 AFLYLLLSLGSPQHPGAIYTLRSTIPIGAGLGSSASVCVCLSAALLLQIRTLAGPHPDQP 272
Query: 175 LSENDKHI--VNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLD 232
E + I +N+WAF+GE C HG PSG+DN V+ G A++F + ++ + + L
Sbjct: 273 PDEAEVQIERINRWAFVGEMCTHGNPSGVDNTVSAGGKAVIFRRTDYS---KPPSVRSLP 329
Query: 233 DFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSK 292
FP +P++L TR PRST VA+V L E+ P V + ILDA+ + L E++ K
Sbjct: 330 TFPELPLLLVDTRQPRSTAVEVAKVGKL-KEEHPVVTESILDAIDKLTLSAEELLDGCEK 388
Query: 293 CKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIXXXXXXXX 352
T+ E+ E+L L+RINHG LVS+GVSHP LE I+ L D I
Sbjct: 389 TGVTE--------EVLERLGTLVRINHGFLVSLGVSHPRLERIRELVDFANIGWTKLTGA 440
Query: 353 XXXXXXXXXXRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLL 399
R D + + + KL + + +ET LGG G +L
Sbjct: 441 GGGGCAITLLRPDADKNAVRDLEAKLAAE-GFAKYETTLGGDGIGVL 486
>gi|169773659|ref|XP_001821298.1| [Aspergillus oryzae]
gi|83769159|dbj|BAE59296.1| unnamed protein product [Aspergillus oryzae]
Length = 534
Score = 190 bits (482), Expect = 2e-46, Method: Composition-based stats.
Identities = 140/411 (34%), Positives = 207/411 (50%), Gaps = 28/411 (6%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISE-SSAPDTIELDFPDISF 59
M+ F+ SAPGKVI+FGEH+ V+ K A+AA++S LR+YLL++ + + TI L+F DI
Sbjct: 86 MAPAFMVSAPGKVIVFGEHAVVHGKAAMAAAIS-LRSYLLVTTLTKSQRTITLNFRDIGL 144
Query: 60 NHKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLS----ESFHYH-- 113
NH WSI++ Q +K + EL+ + PL+ ++S E H
Sbjct: 145 NHTWSIDELPWDLFHQPTKKKYY--YDLVTSIDPELLDAILPLVERISPDLPEDKRKHQR 202
Query: 114 -AAFCFLYMFVCL-CPHAKNIKFSLKSTLPIXXXXXXXXXXXX-XXXXXXXYLGGLIGSN 170
AA FLY+F L P ++L+ST+P + L G +
Sbjct: 203 GAATAFLYLFCALGSPQHPGAIYTLRSTIPTGAGLGSSASICVCISAALLLQIRTLAGPH 262
Query: 171 DLEKLSENDKHI--VNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNF 228
+ E + I +N+WAF+GE CIHG PSG+DN VA G A++F + ++ ++
Sbjct: 263 PDQPPDEAEVQIERINRWAFVGEMCIHGNPSGVDNTVAAGGKAVIFRRGDYSKPPAVSS- 321
Query: 229 KFLDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMT 288
L +FP +P++L TR RST VA+V L E+ P V + ILD + + EI+
Sbjct: 322 --LPNFPELPLLLVDTRQSRSTAVEVAKVGQLKEEQ-PLVTEAILDTIEKVNASAQEII- 377
Query: 289 KLSKCKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIXXXX 348
+ TD + + + E++ LIRINHGLLVS+GVSHP LE I+ L D I
Sbjct: 378 -----RETDSSGI--SKDTLERIGALIRINHGLLVSLGVSHPRLERIRELVDFANIGWTK 430
Query: 349 XXXXXXXXXXXXXXRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLL 399
R D I ++KL D+ + +ET LGG G +L
Sbjct: 431 LTGAGGGGCAITLLRPDADPSAIRQLEEKL-DEEGFAKYETTLGGDGVGVL 480
>gi|67526823|ref|XP_661473.1| hypothetical protein AN3869.2 [Aspergillus nidulans FGSC A4]
gi|40739944|gb|EAA59134.1| hypothetical protein AN3869.2 [Aspergillus nidulans FGSC A4]
Length = 735
Score = 189 bits (479), Expect = 4e-46, Method: Composition-based stats.
Identities = 134/407 (32%), Positives = 206/407 (50%), Gaps = 28/407 (6%)
Query: 5 FLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISE-SSAPDTIELDFPDISFNHKW 63
F+ SAPGKVI++GEH+ V+ K A+AA++S LR+YLL++ S + TI L+F D + NH W
Sbjct: 291 FMVSAPGKVIVYGEHAVVHGKAAMAAAIS-LRSYLLVTTLSKSQRTITLNFRDTNLNHTW 349
Query: 64 SINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLS-------ESFHYHAAF 116
I+ + +K T L QEL + P + +S H +A
Sbjct: 350 DIDQLPWDLFHHPSKKKYYYDLVTT--LDQELYDAIQPHVEDISPDAPEEMRKIHKRSAS 407
Query: 117 CFLYMFVCL-CPHAKNIKFSLKSTLPIXXXXXXXXXX-XXXXXXXXXYLGGLIGSNDLEK 174
FLY+F+ L P + ++L+ST+PI + L G + +
Sbjct: 408 AFLYLFLSLGSPQSAGAIYTLRSTIPIGAGLGSSASVCVCMSAALLVQIRTLAGPHPDQP 467
Query: 175 LSENDKHI--VNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLD 232
E + I +N+WAF+GE CIHG PSG+DN V+ G A++F + ++ + + L
Sbjct: 468 PDEAEVQIERINRWAFVGEMCIHGNPSGVDNTVSAGGKAVIFRRGDYSKPPSVTS---LP 524
Query: 233 DFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSK 292
FP +P++L TR RST VA+V L E +P V + ILDA+ +++ + +
Sbjct: 525 TFPELPLLLVDTRQGRSTAVEVAKVGALRKE-WPVVTESILDAIDNVTASAEKVIREPNP 583
Query: 293 CKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIXXXXXXXX 352
+G ++ + +QL LIRINHG LVS+GVSHP LE I+ L D I
Sbjct: 584 -EGLSEKTL-------QQLGTLIRINHGFLVSLGVSHPRLERIRELVDYADIGWTKLTGA 635
Query: 353 XXXXXXXXXXRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLL 399
R D+ + + K +LQD+ ++ +ET LGG G +L
Sbjct: 636 GGGGCAITLLRPDLNDDSLRQLKSQLQDE-NFGIYETTLGGDGVGVL 681
>gi|39978123|ref|XP_370449.1| hypothetical protein MGG_06946 [Magnaporthe grisea 70-15]
gi|145013479|gb|EDJ98120.1| hypothetical protein MGG_06946 [Magnaporthe grisea 70-15]
Length = 494
Score = 186 bits (473), Expect = 2e-45, Method: Composition-based stats.
Identities = 131/394 (33%), Positives = 203/394 (51%), Gaps = 29/394 (7%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISE-SSAPDTIELDFPDISF 59
M F+ SAPGKVI+FGEHS VY K AVAA+++ LR+YLL++ S + TI L FPDI
Sbjct: 43 MMPAFMVSAPGKVIVFGEHSVVYGKKAVAAAIN-LRSYLLVTALSKSKRTITLRFPDIDL 101
Query: 60 NHKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLS-------ESFHY 112
H W+I+D T Q + +K L +L+ + P L +S H
Sbjct: 102 IHTWNIDDLPWSTFSQPSKKKYY--YDLVTSLDPDLMDAIQPHLEPVSSDAPDAQRKVHM 159
Query: 113 HAAFCFLYMFVCLCPHA-KNIKFSLKSTLPIXXXXXXXXXXXX-XXXXXXXYLGGLIGSN 170
AA FLY+F+ L HA ++L+ST+PI + L G +
Sbjct: 160 SAAAAFLYLFMSLGSHAFPGGIYTLRSTIPIGAGLGSSASISACLSAALLLQIRTLSGPH 219
Query: 171 DLEKLSENDKHI--VNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEK-DSHNGTINTNN 227
+ E + +N+WAF+ E CIHG PSG+DN V+T G A++F++ D + T
Sbjct: 220 PDQPPDEARVQVERINRWAFVAEMCIHGNPSGVDNTVSTQGKAVVFQRLDYARPPVVTPM 279
Query: 228 FKFLDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIM 287
+ DFP +P+++ T+ +STK V +V L E P+++ ILD+M + +++
Sbjct: 280 W----DFPELPLLVVDTKQAKSTKYEVEKVAKL-RETHPKIVNSILDSMDKLTQAATDVL 334
Query: 288 TKLSKCKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIXXX 347
T + D+E VE+ +++ EL+ +NHGLLVS+GVSHP LE ++ L D I
Sbjct: 335 TD----EDFDNEDVES----LQKVGELMGMNHGLLVSLGVSHPRLERVRELVDHEGIGWT 386
Query: 348 XXXXXXXXXXXXXXXRRDITQEQIDSFKKKLQDD 381
R D+ +E+++ K++L +
Sbjct: 387 KLTGAGGGGCSITLMRPDVPREKLERLKERLDHE 420
>gi|119181177|ref|XP_001241830.1| hypothetical protein CIMG_05726 [Coccidioides immitis RS]
gi|90300616|gb|EAS30247.1| hypothetical protein CIMG_05726 [Coccidioides immitis RS]
Length = 612
Score = 186 bits (472), Expect = 3e-45, Method: Composition-based stats.
Identities = 130/412 (31%), Positives = 205/412 (49%), Gaps = 30/412 (7%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISE-SSAPDTIELDFPDISF 59
M+ PF+ SAPGKVI+FGEH+ V+ K A+AA++S LR+YLL++ S + T+ L+F D
Sbjct: 163 MAPPFMVSAPGKVIVFGEHAVVHGKKAMAAAIS-LRSYLLVTTLSKSRRTVTLNFRDTGL 221
Query: 60 NHKWSINDFNAITEDQVN-SQKLAKAQQATDGLSQELVSLLDPLLAQLS-------ESFH 111
+H W D +++ D N S K L +L+ + P ++ +S H
Sbjct: 222 DHTW---DIDSLPWDVFNHSSKKKFYYDRVTSLDPDLLDAIRPHISNVSPDKPPEVRKVH 278
Query: 112 YHAAFCFLYMFVCL-CPHAKNIKFSLKSTLPIXXXXXXXXXX-XXXXXXXXXYLGGLIGS 169
+A FLY+++ L P + ++L+ST+PI + L G
Sbjct: 279 QGSASAFLYLYLSLGSPQSHGAIYTLRSTIPIGAGLGSSASVCVCLSAALLLQIRALAGP 338
Query: 170 NDLEKLSENDKHI--VNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNN 227
+ + E++ I +N+WAF+GE CIHG PSG+DN V+ G A++F + ++
Sbjct: 339 HPDQPFDESEVQIERINRWAFVGELCIHGNPSGVDNTVSAGGKAVIFRRGDYS---KPPT 395
Query: 228 FKFLDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIM 287
+ DFP +P++L +R RST VA+V L K + A+ +C L G++ +
Sbjct: 396 VIPILDFPELPLLLVNSRQSRSTATEVAKVGTL---------KKLHPAITDCLLDGIDQV 446
Query: 288 TKLSKCKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIXXX 347
T + + + + ++E L RINHGLLVS+GVSHP LE I+ L D I
Sbjct: 447 TTSAHDFISSENFDKNSSETLNYFGTLFRINHGLLVSLGVSHPRLERIRELVDHTGIGWT 506
Query: 348 XXXXXXXXXXXXXXXRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLL 399
R D + +++L D+ YE +ET LGG G +L
Sbjct: 507 KLTGAGGGGCAITLIRTDRESTALKPLERQL-DEEGYERYETTLGGQGVGVL 557
>gi|70994538|ref|XP_752047.1| mevalonate kinase [Aspergillus fumigatus Af293]
gi|66849681|gb|EAL90009.1| mevalonate kinase [Aspergillus fumigatus Af293]
Length = 538
Score = 181 bits (458), Expect = 1e-43, Method: Composition-based stats.
Identities = 133/414 (32%), Positives = 204/414 (49%), Gaps = 34/414 (8%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISE-SSAPDTIELDFPDISF 59
M+ F+ SAPGKVI++GEH+ V+ K A+AA++S LR+YLL++ S + TI ++F DI
Sbjct: 88 MAPAFMVSAPGKVIVYGEHAVVHGKAAMAAAIS-LRSYLLVTTLSKSQRTITMNFRDIGL 146
Query: 60 NHKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLS-------ESFHY 112
+H W+I++ + +K L ELV+ + P +S H
Sbjct: 147 DHTWNIDELPWDVFHHPSKKKF--YYDLVTSLDPELVAAIQPHADAVSPDKPEDVRKIHR 204
Query: 113 HAAFCFLYMFVCL-CPHAKNIKFSLKSTLPIXXXXXXXXXX-XXXXXXXXXYLGGLIGSN 170
+A FLY+F+ L ++L+ST+PI + L G +
Sbjct: 205 RSASAFLYLFLSLGSSQNPGAIYTLRSTIPIGAGLGSSASVCVCLSAALLLQIRTLAGPH 264
Query: 171 DLEKLSENDKHI--VNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNF 228
+ E + I +N+WAF+GE C HG PSG+DN V+ G A++F ++ ++
Sbjct: 265 PDQPPDEAEVQIERINRWAFVGEMCTHGNPSGVDNTVSAGGKAVVFRREDYSKPPTVTP- 323
Query: 229 KFLDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMT 288
L +FP +P++L TR RST VA+V L +++P V IL+A+ + L + +
Sbjct: 324 --LLNFPELPLLLVDTRQSRSTAVEVAKVGKL-KDEYPVVTDSILEAIDQVTLAAQQKIQ 380
Query: 289 KLSKCKGTDDEAVETNNELY---EQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIX 345
++S TN Y E L LIRINHG LVS+GVSHP LE I+ L D I
Sbjct: 381 EIS-----------TNGISYRTLEDLGTLIRINHGFLVSLGVSHPRLERIRELVDYADIG 429
Query: 346 XXXXXXXXXXXXXXXXXRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLL 399
R DI +E + ++KL + + +ET LGG G +L
Sbjct: 430 WTKLTGAGGGGCAITLLRPDIKEEAVRELEEKLSAE-GFVKYETTLGGDGIGVL 482
>gi|119500972|ref|XP_001267243.1| mevalonate kinase [Neosartorya fischeri NRRL 181]
gi|119415408|gb|EAW25346.1| mevalonate kinase [Neosartorya fischeri NRRL 181]
Length = 538
Score = 178 bits (451), Expect = 9e-43, Method: Composition-based stats.
Identities = 131/411 (31%), Positives = 201/411 (48%), Gaps = 28/411 (6%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISE-SSAPDTIELDFPDISF 59
M+ F+ SAPGKVI++GEH+ V+ K A+AA++S LR+YLL++ S + TI ++F DI
Sbjct: 88 MAPAFMVSAPGKVIVYGEHAVVHGKAAMAAAIS-LRSYLLVTTLSKSQRTITMNFRDIGL 146
Query: 60 NHKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLS-------ESFHY 112
+H W+I++ + +K L ELV+ + P +S H
Sbjct: 147 DHTWNIDELPWDVFHHPSKKKF--YYDLVTSLDPELVAAIQPHADAVSPEKPEDVRKIHR 204
Query: 113 HAAFCFLYMFVCL-CPHAKNIKFSLKSTLPIXXXXXXXXXX-XXXXXXXXXYLGGLIGSN 170
+A FLY+F+ L ++L+ST+PI + L G +
Sbjct: 205 RSASAFLYLFLSLGSSQNPGAIYTLRSTIPIGAGLGSSASVCVCLSAALLLQIRTLAGPH 264
Query: 171 DLEKLSENDKHI--VNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNF 228
+ E + I +N+WAF+GE C HG PSG+DN V+ G A++F ++ ++
Sbjct: 265 PDQPPDEAEVQIERINRWAFVGEMCTHGNPSGVDNTVSAGGKAVVFRREDYSKPPTVTP- 323
Query: 229 KFLDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMT 288
L +FP +P++L TR RST VA+V L E P V IL+A+ + L + +
Sbjct: 324 --LLNFPELPLLLVDTRQSRSTAVEVAKVGKLKDEH-PVVADSILEAIDQVTLAAQQKIQ 380
Query: 289 KLSKCKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIXXXX 348
++S G + + E L LIRINHG LVS+GVSHP LE I+ L D I
Sbjct: 381 EIST-NGISERTL-------EDLGTLIRINHGFLVSLGVSHPRLERIRELVDYADIGWTK 432
Query: 349 XXXXXXXXXXXXXXRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLL 399
R D +E + ++KL + + +ET LGG G +L
Sbjct: 433 LTGAGGGGCAITLLRPDTKEEAVRELEEKLNAE-GFVKYETTLGGDGIGVL 482
>gi|71022827|ref|XP_761643.1| hypothetical protein UM05496.1 [Ustilago maydis 521]
gi|46101196|gb|EAK86429.1| hypothetical protein UM05496.1 [Ustilago maydis 521]
Length = 953
Score = 147 bits (372), Expect = 1e-33, Method: Composition-based stats.
Identities = 120/398 (30%), Positives = 187/398 (46%), Gaps = 28/398 (7%)
Query: 6 LTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFNHKWSI 65
+ SAPGKVI+FGEH+ V+ AVAASV ALR Y +S I LD PD+ H W+I
Sbjct: 535 VVSAPGKVILFGEHAVVHGITAVAASV-ALRCYANVSPRE-DGKISLDLPDLGVIHTWNI 592
Query: 66 ND--FNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQ-LSESFHYHAA-FCFLYM 121
D ++A+ + + D L + L+ ++ ++ ++ES HAA FL +
Sbjct: 593 ADLPWSAV------PKSIQGGGAVPDSLDKTLIGAIEKVVGDTVNESERSHAASIAFLVL 646
Query: 122 FVCLCPHA--KNIKFSLKSTLPIXXXXXXXXXXXXXXXXXXXYLGGLIGSNDLEKLSEND 179
++C+ A + F L+S LPI L G I + E +E+
Sbjct: 647 YMCIAGQADARAQAFVLRSALPIGAGLGSSAALSSCLAAALTILYGRIPAPGSELSAEHS 706
Query: 180 KHIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLDDFPAIPM 239
HI N+WAF+ EK IHGTPSG+DN VA +G A+ F + + T+ N L F +
Sbjct: 707 THI-NEWAFLSEKVIHGTPSGVDNTVAVHGGAIAFTRAHPSNTLTANKMNKLKGFSSFRF 765
Query: 240 ILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSKCKGTDDE 299
+L + + R K L+A V +K E + AL ++ + ++ T +
Sbjct: 766 LLVDSCVGREGKKLIAHV---AAQKESEPTRV------NAALARIQTIADSAQLVLTGNS 816
Query: 300 AVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIXXXXXXXXXXXXX-- 357
+ + +E QL ELI+ NH LV + VSH LELIKN ++
Sbjct: 817 GL-SRSEQVAQLRELIKQNHSELVGLEVSHASLELIKNKTESFAPDQLATKLTGAGGGGC 875
Query: 358 XXXXXRRDITQEQIDSFKKKLQDDFSYETFETDLGGTG 395
D +E++ +L++ ++ +ET +GG G
Sbjct: 876 AVTLLPDDFEEEKVKELMSELENA-GFKCYETRVGGDG 912
>gi|72125755|ref|XP_790690.1| PREDICTED: similar to Mevalonate kinase (MK) [Strongylocentrotus
purpuratus]
gi|115614665|ref|XP_001200159.1| PREDICTED: similar to Mevalonate kinase (MK) [Strongylocentrotus
purpuratus]
Length = 413
Score = 133 bits (334), Expect = 3e-29, Method: Composition-based stats.
Identities = 99/339 (29%), Positives = 162/339 (47%), Gaps = 38/339 (11%)
Query: 8 SAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFNHKWSIND 67
SAPGK+I+ GEH+ V+ K A+AA ++ LR+YL + E + + L+ PDI W + +
Sbjct: 19 SAPGKIILHGEHAVVHGKTALAAGLN-LRSYLCLKEKDS-GRLHLNLPDIDLERSWDVLE 76
Query: 68 FNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLA-QLSESFHYHAAFCFLYMFVCLC 126
D +NS + S E++ L L +E+ A FLY+++C+
Sbjct: 77 LQEQFRDLLNSDVMEVKP------SVEIMQRLRLFLGYSDTETTKRLAVMAFLYLYLCIA 130
Query: 127 PHAKNIKFSLKSTLPIXXXXXXXXXXXXXXXXXXXYLGGLIG----------SNDLEKLS 176
+N KF + TL + GL+ S++ S
Sbjct: 131 --GRNGKFPILDTL-VSSALPPGAGLGSSAAFSVCLAAGLLTWAKAIIPLSLSDNTLDWS 187
Query: 177 ENDKHIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLDDFPA 236
D ++N WA+ GE+ IHG PSGIDN+++ +G A+ + + L++ P
Sbjct: 188 REDMELINTWAYEGERVIHGNPSGIDNSISVHGGAIEYRQKV---------ITPLENMPE 238
Query: 237 IPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSKCKGT 296
+ ++L T + RSTK+LVA V+ +K+P+V PILD++ E + + + L +
Sbjct: 239 LSILLVNTCVARSTKELVAGVQ-RRHDKYPKVYGPILDSIEEISQECKRTLQALKTGESL 297
Query: 297 DDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELI 335
D + ++ L EL+ IN LL IGVSHP + I
Sbjct: 298 DKDGA------FKSLGELVDINQQLLYVIGVSHPAINNI 330
>gi|123227559|emb|CAM15186.1| novel protein similar to vertebrate mevalonate kinase (mevalonic
aciduria) (MVK) [Danio rerio]
Length = 396
Score = 133 bits (334), Expect = 3e-29, Method: Composition-based stats.
Identities = 109/344 (31%), Positives = 164/344 (47%), Gaps = 38/344 (11%)
Query: 2 SLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFNH 61
S SAPGKVI+ GEHS V+ K A+A SV+ LRTYL + +S++ + ++ P+I
Sbjct: 3 SRELFVSAPGKVILHGEHSVVHGKVALAVSVN-LRTYLRL-QSTSSGQVCINLPNIDTFL 60
Query: 62 KWSINDFNAITEDQVNSQKLAKAQQATDGLSQ--ELVSLLDPLLAQLSESFHYHAAFCFL 119
W I + Q+ K A D L + E + D S A FL
Sbjct: 61 SWEITALQPLLAGSKAEQRDPKELDA-DLLKKLREFTGISDD-----STDTRSMAVLAFL 114
Query: 120 YMFVCLCPHA-KNIKFSLKSTLPIXXXXXXXXXXXXXXXXXXXYLGG-----LIGSNDLE 173
YM++ + + +I S+ S LP G L+ +
Sbjct: 115 YMYITVFAESLASITVSVWSELPTGAGLGSSAAYNVCLSAALLSARGNISPLLMAQQESA 174
Query: 174 KLSENDKHIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLDD 233
+ S+++ ++N+WAF+GEK IHG PSG+DNAV T+G L + H+G I L
Sbjct: 175 RWSKDEMELINRWAFMGEKIIHGNPSGVDNAVGTWGGFLRY----HSGNITP-----LSW 225
Query: 234 FPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSKC 293
P + ++LT T++PRSTK LV+ V+ + KFP VM+P+L+++ + C
Sbjct: 226 VPILRILLTNTKVPRSTKVLVSGVKDKIN-KFPSVMRPVLESVSAVS----------CTC 274
Query: 294 KGTDDEAVE--TNNELYEQLLELIRINHGLLVSIGVSHPGLELI 335
+ T E E + E Y L ELI IN L +GV H L+ +
Sbjct: 275 EQTLTEMAEHGPSAEHYNILEELIDINQHHLNVMGVGHSSLDTL 318