BLASTP 2.2.17 [Aug-26-2007]
Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Reference for composition-based statistics:
Schäffer, Alejandro A., L. Aravind, Thomas L. Madden,
Schaffer, Alejandro A., L. Aravind, Thomas L. Madden,
Sergei Shavirin, John L. Spouge, Yuri I. Wolf,
Eugene V. Koonin, and Stephen F. Altschul (2001),
"Improving the accuracy of PSI-BLAST protein database searches with
composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005.
Query= ENSG00000110921__[Homo_sapiens]
(396 letters)
Database: All non-redundant GenBank CDS
translations+PDB+SwissProt+PIR+PRF excluding environmental samples
from WGS projects
6,899,187 sequences; 2,350,152,223 total letters
Searching..................................................done
Results from round 1
Score E
Sequences producing significant alignments: (bits) Value
emb|CAA53059.1| unnamed protein product [Hepatitis B virus] 767 0.0
ref|NP_000422.1| mevalonate kinase [Homo sapiens] >gi|16700... 762 0.0
gb|AAQ02416.1| mevalonate kinase [synthetic construct] 761 0.0
dbj|BAD92959.1| mevalonate kinase variant [Homo sapiens] 761 0.0
ref|XP_001105759.1| PREDICTED: mevalonate kinase isoform 2 ... 726 0.0
ref|XP_543435.2| PREDICTED: similar to Mevalonate kinase (M... 639 0.0
ref|NP_001015528.1| mevalonate kinase [Bos taurus] >gi|7506... 632 e-179
gb|AAX08684.1| mevalonate kinase [Bos taurus] 630 e-179
ref|XP_001496887.1| PREDICTED: similar to mevalonate kinase... 621 e-176
ref|XP_001105689.1| PREDICTED: mevalonate kinase isoform 1 ... 607 e-172
gb|AAX46713.1| mevalonate kinase [Bos taurus] 603 e-171
ref|NP_112325.1| mevalonate kinase [Rattus norvegicus] >gi|... 596 e-168
ref|NP_076045.1| mevalonate kinase [Mus musculus] >gi|89281... 582 e-164
dbj|BAE28997.1| unnamed protein product [Mus musculus] 573 e-162
ref|XP_001364115.1| PREDICTED: similar to mevalonate kinase... 551 e-155
ref|XP_918559.1| PREDICTED: similar to mevalonate kinase [M... 513 e-144
emb|CAM15186.1| novel protein similar to vertebrate mevalon... 419 e-115
ref|NP_001007350.1| hypothetical protein LOC492477 [Danio r... 417 e-115
gb|AAX46707.1| mevalonate kinase [Bos taurus] 414 e-114
emb|CAG08527.1| unnamed protein product [Tetraodon nigrovir... 399 e-109
gb|EAW97870.1| mevalonate kinase (mevalonic aciduria), isof... 377 e-102
gb|ABR68258.1| mevalonate kinase [Monodelphis domestica] 373 e-101
ref|XP_790690.1| PREDICTED: similar to Mevalonate kinase (M... 331 5e-89
ref|XP_001628178.1| predicted protein [Nematostella vectens... 289 2e-76
gb|EDL19907.1| mevalonate kinase, isoform CRA_a [Mus muscul... 266 2e-69
gb|EDM13938.1| mevalonate kinase, isoform CRA_b [Rattus nor... 257 1e-66
gb|EDM13939.1| mevalonate kinase, isoform CRA_c [Rattus nor... 256 2e-66
ref|XP_001779131.1| predicted protein [Physcomitrella paten... 251 7e-65
ref|XP_567851.1| cystathionine beta-lyase [Cryptococcus neo... 246 2e-63
ref|XP_567850.1| cystathionine beta-lyase [Cryptococcus neo... 246 2e-63
gb|AAD45421.1|L77688_1 mevalonate kinase [Arabidopsis thali... 238 5e-61
gb|AAL18925.1|AF429384_1 mevalonate kinase [Hevea brasilien... 236 2e-60
gb|ABK95983.1| unknown [Populus trichocarpa] 235 4e-60
ref|NP_198097.1| MK/MVK; mevalonate kinase [Arabidopsis tha... 234 8e-60
ref|XP_645383.1| hypothetical protein DDBDRAFT_0168621 [Dic... 233 2e-59
emb|CAO17636.1| unnamed protein product [Vitis vinifera] 233 3e-59
ref|XP_001527900.1| hypothetical protein LELG_00420 [Lodder... 232 5e-59
ref|XP_723495.1| mevalonate kinase [Candida albicans SC5314... 229 2e-58
gb|ABD32397.1| Mevalonate and galactokinase [Medicago trunc... 225 4e-57
ref|XP_460851.1| hypothetical protein DEHA0F12188g [Debaryo... 222 4e-56
ref|XP_001382664.2| mevalonate kinase [Pichia stipitis CBS ... 220 2e-55
ref|NP_001064360.1| Os10g0329300 [Oryza sativa (japonica cu... 219 3e-55
ref|XP_001231562.1| PREDICTED: hypothetical protein [Gallus... 217 1e-54
ref|NP_592837.1| mevalonate kinase Erg12 (predicted) [Schiz... 209 3e-52
ref|XP_961360.1| hypothetical protein NCU03633 [Neurospora ... 206 2e-51
gb|EAW97871.1| mevalonate kinase (mevalonic aciduria), isof... 206 2e-51
gb|AAL31086.1|AC091749_15 putative mevalonate kinase [Oryza... 206 2e-51
ref|XP_001836355.1| hypothetical protein CC1G_06440 [Coprin... 202 4e-50
ref|XP_001911734.1| unnamed protein product [Podospora anse... 201 1e-49
ref|XP_001229023.1| hypothetical protein CHGG_02507 [Chaeto... 200 2e-49
ref|XP_001271672.1| mevalonate kinase [Aspergillus clavatus... 199 3e-49
ref|XP_001214601.1| conserved hypothetical protein [Aspergi... 199 3e-49
ref|NP_001022868.1| Y42G9A.4c [Caenorhabditis elegans] >gi|... 197 1e-48
ref|XP_001559870.1| hypothetical protein BC1G_01429 [Botryo... 197 1e-48
ref|XP_661473.1| hypothetical protein AN3869.2 [Aspergillus... 197 1e-48
ref|NP_001022869.1| Y42G9A.4d [Caenorhabditis elegans] >gi|... 197 2e-48
gb|EDP50156.1| mevalonate kinase [Aspergillus fumigatus A1163] 196 3e-48
ref|XP_752047.1| mevalonate kinase [Aspergillus fumigatus A... 196 3e-48
ref|NP_001022867.1| Y42G9A.4b [Caenorhabditis elegans] >gi|... 196 3e-48
ref|XP_001730996.1| hypothetical protein MGL_1995 [Malassez... 195 7e-48
ref|XP_001267243.1| mevalonate kinase [Neosartorya fischeri... 194 7e-48
ref|XP_001821298.1| hypothetical protein [Aspergillus oryza... 192 3e-47
ref|XP_001483309.1| hypothetical protein PGUG_04038 [Pichia... 192 5e-47
ref|XP_001593159.1| hypothetical protein SS1G_06081 [Sclero... 191 6e-47
ref|NP_013935.1| Mevalonate kinase, acts in the biosynthesi... 191 7e-47
gb|EDN64144.1| mevalonate kinase [Saccharomyces cerevisiae ... 191 7e-47
ref|XP_452532.1| unnamed protein product [Kluyveromyces lac... 191 1e-46
ref|XP_500956.1| hypothetical protein [Yarrowia lipolytica]... 189 3e-46
ref|XP_972334.1| PREDICTED: similar to mevalonate kinase [T... 188 7e-46
ref|XP_761643.1| hypothetical protein UM05496.1 [Ustilago m... 188 7e-46
ref|XP_001900710.1| mevalonate kinase family protein [Brugi... 187 1e-45
gb|EEH48028.1| mevalonate kinase [Paracoccidioides brasilie... 187 2e-45
ref|NP_985191.1| AER335Wp [Ashbya gossypii ATCC 10895] >gi|... 187 2e-45
ref|XP_001608063.1| PREDICTED: similar to mevalonate kinase... 185 7e-45
ref|XP_446138.1| unnamed protein product [Candida glabrata]... 184 1e-44
ref|XP_001401587.1| hypothetical protein An04g02190 [Asperg... 184 1e-44
ref|XP_386088.1| hypothetical protein FG05912.1 [Gibberella... 184 2e-44
ref|XP_001846214.1| mevalonate kinase [Culex pipiens quinqu... 183 2e-44
ref|XP_001241830.1| hypothetical protein CIMG_05726 [Coccid... 182 4e-44
ref|XP_370449.1| hypothetical protein MGG_06946 [Magnaporth... 181 8e-44
ref|XP_001657825.1| mevalonate kinase [Aedes aegypti] >gi|1... 180 1e-43
ref|XP_624545.2| PREDICTED: similar to Mevalonate kinase (M... 180 1e-43
ref|XP_001644409.1| hypothetical protein Kpol_1064p33 [Vand... 180 2e-43
ref|NP_001093299.1| mevalonate kinase [Bombyx mori] >gi|146... 179 4e-43
emb|CAN77024.1| hypothetical protein [Vitis vinifera] 177 1e-42
gb|EAZ05750.1| hypothetical protein OsI_026982 [Oryza sativ... 176 2e-42
gb|EEH37797.1| mevalonate kinase [Paracoccidioides brasilie... 174 1e-41
emb|CAF88123.1| unnamed protein product [Tetraodon nigrovir... 173 2e-41
gb|EAZ15677.1| hypothetical protein OsJ_029886 [Oryza sativ... 173 2e-41
gb|EAY78050.1| hypothetical protein OsI_032009 [Oryza sativ... 172 6e-41
ref|XP_319701.4| AGAP008947-PA [Anopheles gambiae str. PEST... 171 1e-40
ref|NP_001027412.1| CG33671 CG33671-PA [Drosophila melanoga... 160 2e-37
ref|XP_793882.1| PREDICTED: similar to mevalonate kinase va... 153 3e-35
ref|XP_001540400.1| conserved hypothetical protein [Ajellom... 153 3e-35
gb|EDU45497.1| mevalonate kinase [Pyrenophora tritici-repen... 153 3e-35
gb|AAF82406.1| truncated mevalonate kinase [Homo sapiens] 144 1e-32
ref|YP_920295.1| mevalonate kinase [Thermofilum pendens Hrk... 128 7e-28
ref|NP_126232.1| mevalonate kinase [Pyrococcus abyssi GE5] ... 128 9e-28
gb|ABG24208.1| mevalonate kinase [Arnebia euchroma] 126 4e-27
ref|NP_143478.1| mevalonate kinase [Pyrococcus horikoshii O... 125 7e-27
dbj|BAA24409.1| mevalonate kinase [Saccharomyces cerevisiae] 122 7e-26
ref|NP_001022866.1| Y42G9A.4a [Caenorhabditis elegans] >gi|... 120 2e-25
ref|XP_001666415.1| hypothetical protein CBG21109 [Caenorha... 116 3e-24
ref|YP_183887.1| mevalonate kinase [Thermococcus kodakarens... 116 3e-24
ref|XP_001519270.1| PREDICTED: hypothetical protein, partia... 115 8e-24
ref|NP_579366.1| mevalonate kinase [Pyrococcus furiosus DSM... 113 3e-23
ref|ZP_01906658.1| mevalonate kinase [Plesiocystis pacifica... 112 6e-23
ref|XP_001516501.1| PREDICTED: hypothetical protein, partia... 108 8e-22
ref|YP_842907.1| mevalonate kinase [Methanosaeta thermophil... 105 5e-21
ref|XP_001794454.1| hypothetical protein SNOG_03909 [Phaeos... 103 2e-20
ref|YP_001581649.1| mevalonate kinase [Nitrosopumilus marit... 103 3e-20
ref|NP_633786.1| mevalonate kinase [Methanosarcina mazei Go... 103 3e-20
ref|YP_566996.1| mevalonate kinase [Methanococcoides burton... 102 5e-20
ref|YP_001013073.1| Mevalonate kinase [Hyperthermus butylic... 102 6e-20
ref|XP_001325649.1| mevalonate kinase family protein [Trich... 102 6e-20
ref|YP_658630.1| mevalonate kinase [Haloquadratum walsbyi D... 101 1e-19
ref|YP_447890.1| putative mevalonate kinase [Methanosphaera... 99 5e-19
ref|ZP_03999700.1| mevalonate kinase [Halogeometricum borin... 97 2e-18
ref|YP_134862.1| mevalonate kinase [Haloarcula marismortui ... 96 3e-18
ref|ZP_02015315.1| mevalonate kinase [Halorubrum lacusprofu... 96 6e-18
gb|ABR67422.1| mevalonate kinase 1 [Cucumis melo] 94 2e-17
ref|YP_001040239.1| mevalonate kinase [Staphylothermus mari... 94 2e-17
ref|YP_684687.1| mevalonate kinase [uncultured methanogenic... 94 2e-17
ref|NP_148611.1| mevalonate kinase [Aeropyrum pernix K1] >g... 87 3e-15
ref|YP_001276466.1| mevalonate kinase [Roseiflexus sp. RS-1... 86 4e-15
ref|YP_001547075.1| mevalonate kinase [Herpetosiphon aurant... 86 7e-15
ref|YP_327075.1| mevalonate kinase [Natronomonas pharaonis ... 82 6e-14
ref|XP_001744350.1| predicted protein [Monosiga brevicollis... 82 9e-14
ref|ZP_03943398.1| possible mevalonate kinase [Lactobacillu... 81 2e-13
ref|YP_001634502.1| mevalonate kinase [Chloroflexus auranti... 80 3e-13
ref|YP_001614848.1| hypothetical protein sce4205 [Sorangium... 80 3e-13
ref|ZP_01695505.1| mevalonate kinase [Bacillus coagulans 36... 79 5e-13
ref|NP_615566.1| mevalonate kinase [Methanosarcina acetivor... 79 7e-13
ref|ZP_03940390.1| possible mevalonate kinase [Lactobacillu... 79 7e-13
ref|YP_504301.1| mevalonate kinase [Methanospirillum hungat... 79 7e-13
ref|YP_804427.1| Mevalonate kinase [Pediococcus pentosaceus... 79 7e-13
ref|YP_304960.1| mevalonate kinase [Methanosarcina barkeri ... 79 8e-13
ref|ZP_03954541.1| possible mevalonate kinase [Lactobacillu... 78 1e-12
ref|YP_001431846.1| mevalonate kinase [Roseiflexus castenho... 78 2e-12
pdb|1VIS|A Chain A, Crystal Structure Of Mevalonate Kinase 77 3e-12
ref|ZP_01465063.1| mevalonate kinase [Stigmatella aurantiac... 76 4e-12
ref|XP_955731.1| mevalonate kinase [Encephalitozoon cunicul... 76 4e-12
ref|ZP_03845964.1| mevalonate kinase [Lactobacillus sakei s... 76 4e-12
ref|YP_001030120.1| hypothetical protein Mlab_0681 [Methano... 76 5e-12
emb|CAF89434.1| unnamed protein product [Tetraodon nigrovir... 76 5e-12
pdb|1KKH|A Chain A, Crystal Structure Of The Methanococcus ... 76 6e-12
ref|NP_248080.1| mevalonate kinase [Methanocaldococcus jann... 76 6e-12
ref|XP_001032429.2| DnaJ domain containing protein [Tetrahy... 75 7e-12
sp|Q50559|KIME_METTH Mevalonate kinase (MK) >gi|1184118|gb|... 75 8e-12
ref|NP_280049.1| Mvk [Halobacterium sp. NRC-1] >gi|16923595... 75 8e-12
ref|XP_001567071.1| mevalonate kinase, putative [Leishmania... 75 1e-11
ref|NP_691146.1| mevalonate kinase [Oceanobacillus iheyensi... 74 1e-11
ref|YP_806709.1| Mevalonate kinase [Lactobacillus casei ATC... 74 2e-11
ref|ZP_01946351.1| mevalonate kinase [Coxiella burnetii 'MS... 74 2e-11
ref|NP_819638.1| phosphomevalonate kinase, putative [Coxiel... 74 3e-11
ref|NP_275189.1| mevalonate kinase [Methanothermobacter the... 74 3e-11
ref|XP_001458185.1| hypothetical protein GSPATT00003653001 ... 73 3e-11
ref|YP_395519.1| Mevalonate kinase [Lactobacillus sakei sub... 73 3e-11
ref|YP_633174.1| mevalonate kinase [Myxococcus xanthus DK 1... 73 5e-11
ref|ZP_03873469.1| mevalonate kinase [Halomicrobium mukohat... 72 6e-11
ref|YP_001620791.1| mevalonate kinase [Acholeplasma laidlaw... 70 2e-10
ref|ZP_03957037.1| mevalonate kinase [Lactobacillus ruminis... 70 3e-10
ref|XP_001347016.1| Mevalonate kinase, putative [Paramecium... 70 4e-10
ref|YP_001405370.1| mevalonate kinase [Candidatus Methanore... 69 6e-10
gb|AAO45760.1| mevalonate kinase-like protein [Cucumis melo] 68 1e-09
ref|YP_302212.1| mevalonate kinase [Staphylococcus saprophy... 67 2e-09
ref|ZP_03871887.1| mevalonate kinase [Halorhabdus utahensis... 67 3e-09
ref|ZP_02185318.1| mevalonate kinase [Carnobacterium sp. AT... 65 7e-09
ref|NP_071114.1| mevalonate kinase (mvk) [Archaeoglobus ful... 65 7e-09
ref|YP_001540788.1| mevalonate kinase [Caldivirga maquiling... 64 2e-08
ref|NP_269075.1| mevalonate kinase [Streptococcus pyogenes ... 64 2e-08
ref|XP_001467381.1| mevalonate kinase [Leishmania infantum ... 64 2e-08
ref|NP_607080.1| mevalonate kinase [Streptococcus pyogenes ... 64 2e-08
ref|ZP_01514039.1| mevalonate kinase [Chloroflexus aggregan... 64 2e-08
ref|YP_795031.1| Mevalonate kinase [Lactobacillus brevis AT... 64 3e-08
ref|NP_819639.1| mevalonate kinase, putative [Coxiella burn... 64 3e-08
ref|NP_664399.1| mevalonate kinase [Streptococcus pyogenes ... 63 4e-08
ref|YP_060017.1| Mevalonate kinase [Streptococcus pyogenes ... 63 4e-08
ref|NP_814642.1| mevalonate kinase [Enterococcus faecalis V... 63 4e-08
ref|YP_598349.1| Mevalonate kinase [Streptococcus pyogenes ... 63 5e-08
ref|YP_280130.1| mevalonate kinase [Streptococcus pyogenes ... 62 6e-08
ref|YP_001424028.1| putative phopshomevalonate kinase [Coxi... 62 9e-08
ref|ZP_03947872.1| mevalonate kinase [Enterococcus faecalis... 61 1e-07
ref|XP_814628.1| mevalonate kinase, putative [Trypanosoma c... 61 1e-07
ref|YP_001329799.1| mevalonate kinase [Methanococcus maripa... 61 1e-07
gb|AAG02440.1|AF290093_1 mevalonate kinase [Enterococcus fa... 61 2e-07
ref|ZP_03882650.1| mevalonate kinase [Haliangium ochraceum ... 61 2e-07
ref|YP_001056718.1| mevalonate kinase [Pyrobaculum calidifo... 61 2e-07
ref|ZP_02689018.1| mevalonate kinase [Listeria monocytogene... 61 2e-07
ref|ZP_01926008.1| mevalonate kinase [Listeria monocytogene... 60 2e-07
ref|ZP_01942559.1| mevalonate kinase [Listeria monocytogene... 60 2e-07
ref|XP_001685041.1| mevalonate kinase, putative [Leishmania... 60 3e-07
pdb|2HFU|A Chain A, Crystal Structure Of L. Major Mevalonat... 60 3e-07
ref|NP_720650.1| putative mevalonate kinase [Streptococcus ... 60 3e-07
ref|ZP_00230799.1| mevalonate kinase [Listeria monocytogene... 60 3e-07
ref|YP_012624.1| mevalonate kinase [Listeria monocytogenes ... 60 4e-07
ref|XP_001708461.1| Mevalonate kinase [Giardia lamblia ATCC... 59 5e-07
ref|YP_848214.1| mevalonate kinase [Listeria welshimeri ser... 59 5e-07
ref|YP_535578.1| Mevalonate kinase [Lactobacillus salivariu... 59 7e-07
ref|YP_001047720.1| mevalonate kinase [Methanoculleus maris... 59 7e-07
ref|XP_844557.1| mevalonate kinase, putative [Trypanosoma b... 59 8e-07
ref|NP_469357.1| hypothetical protein lin0010 [Listeria inn... 59 9e-07
ref|NP_463543.1| hypothetical protein lmo0010 [Listeria mon... 59 9e-07
ref|XP_802528.1| mevalonate kinase, putative [Trypanosoma c... 58 1e-06
ref|YP_001209700.1| GHMP kinase family protein [Dichelobact... 57 2e-06
ref|YP_001197657.1| Mevalonate kinase [Streptococcus suis 0... 57 2e-06
pdb|2HFS|A Chain A, Crystal Structure Of L. Major Mevalonat... 57 2e-06
ref|NP_614276.1| Mevalonate kinase [Methanopyrus kandleri A... 57 3e-06
ref|YP_876537.1| mevalonate kinase [Cenarchaeum symbiosum A... 57 3e-06
gb|AAG02424.1|AF290087_1 mevalonate kinase [Staphylococcus ... 57 3e-06
ref|ZP_04008555.1| mevalonate kinase [Lactobacillus salivar... 57 4e-06
ref|YP_929988.1| mevalonate kinase [Pyrobaculum islandicum ... 57 4e-06
ref|ZP_03980950.1| possible Mevalonate kinase [Enterococcus... 56 4e-06
ref|YP_040044.1| mevalonate kinase [Staphylococcus aureus s... 56 4e-06
ref|NP_645362.1| mevalonate kinase [Staphylococcus aureus s... 56 6e-06
ref|NP_785308.1| mevalonate kinase [Lactobacillus plantarum... 55 7e-06
ref|ZP_00604007.1| Mevalonate kinase [Enterococcus faecium ... 55 7e-06
ref|ZP_00875673.1| Mevalonate kinase [Streptococcus suis 89... 55 8e-06
ref|NP_988455.1| Mevalonate kinase [Methanococcus maripalud... 55 8e-06
ref|YP_001096789.1| mevalonate kinase [Methanococcus maripa... 54 2e-05
ref|YP_001737496.1| mevalonate kinase [Candidatus Korarchae... 54 3e-05
ref|YP_001549383.1| mevalonate kinase [Methanococcus maripa... 53 3e-05
ref|YP_254317.1| mevalonate kinase [Staphylococcus haemolyt... 53 4e-05
ref|ZP_01167630.1| GHMP kinase [Oceanospirillum sp. MED92] ... 52 6e-05
ref|YP_001844008.1| mevalonate kinase [Lactobacillus fermen... 52 7e-05
ref|ZP_03944901.1| possible mevalonate kinase [Lactobacillu... 52 7e-05
ref|YP_001274012.1| mevalonate kinase [Methanobrevibacter s... 52 1e-04
ref|YP_001795021.1| mevalonate kinase [Thermoproteus neutro... 52 1e-04
ref|NP_560495.1| mevalonate kinase [Pyrobaculum aerophilum ... 51 2e-04
ref|NP_371114.1| mevalonate kinase [Staphylococcus aureus s... 51 2e-04
ref|YP_118418.1| putative mevalonate kinase [Nocardia farci... 50 3e-04
gb|ACC62032.1| mevalonate kinase [Picrorhiza kurrooa] 50 3e-04
ref|ZP_03913910.1| mevalonate kinase [Leuconostoc mesentero... 50 3e-04
ref|YP_810664.1| Mevalonate kinase [Oenococcus oeni PSU-1] ... 50 4e-04
ref|YP_818851.1| Mevalonate kinase [Leuconostoc mesenteroid... 50 4e-04
ref|ZP_01695503.1| phosphomevalonate kinase [Bacillus coagu... 50 5e-04
ref|YP_001323164.1| mevalonate kinase [Methanococcus vannie... 49 5e-04
ref|ZP_03974667.1| mevalonate kinase [Lactobacillus reuteri... 49 6e-04
ref|YP_001271514.1| mevalonate kinase [Lactobacillus reuter... 49 7e-04
ref|YP_391998.1| GHMP kinase [Thiomicrospira crunogena XCL-... 49 7e-04
emb|CAD24422.1| phosphomevalonate kinase [Paracoccus zeaxan... 49 0.001
ref|ZP_01167629.1| mevalonate kinase, putative [Oceanospiri... 48 0.001
ref|NP_266560.1| mevalonate kinase [Lactococcus lactis subs... 48 0.001
ref|ZP_02519050.1| mevalonate kinase [Borrelia burgdorferi ... 48 0.002
ref|ZP_01544345.1| mevalonate kinase [Oenococcus oeni ATCC ... 47 0.002
ref|YP_001435347.1| mevalonate kinase [Ignicoccus hospitali... 47 0.002
ref|YP_001884107.1| mevalonate kinase [Borrelia hermsii DAH... 47 0.002
ref|YP_001153805.1| mevalonate kinase [Pyrobaculum arsenati... 47 0.002
ref|ZP_02725132.1| mevalonate kinase [Borrelia burgdorferi ... 47 0.002
ref|YP_001031775.1| Mvk protein [Lactococcus lactis subsp. ... 47 0.002
ref|ZP_03957035.1| phosphomevalonate kinase [Lactobacillus ... 47 0.002
ref|NP_212822.1| mevalonate kinase [Borrelia burgdorferi B3... 47 0.002
ref|ZP_02520518.1| mevalonate kinase [Borrelia burgdorferi ... 47 0.002
ref|ZP_02719710.1| mevalonate kinase [Borrelia burgdorferi ... 47 0.002
ref|YP_808480.1| Mevalonate kinase [Lactococcus lactis subs... 47 0.003
ref|YP_001449558.1| mevalonate kinase [Streptococcus gordon... 47 0.004
dbj|BAB07790.1| mevalonate kinase [Streptomyces sp. CL190] 46 0.004
ref|ZP_01273283.1| Mevalonate kinase [Lactobacillus reuteri... 46 0.004
ref|YP_001727922.1| Mevalonate kinase [Leuconostoc citreum ... 46 0.005
dbj|BAD86800.1| mevalonate kinase [Streptomyces sp. KO-3988] 46 0.006
ref|YP_825098.1| galactokinase [Solibacter usitatus Ellin60... 45 0.007
ref|XP_001861666.1| mevalonate kinase [Culex pipiens quinqu... 45 0.008
ref|ZP_03959183.1| possible mevalonate kinase [Lactobacillu... 45 0.008
dbj|BAD86802.1| phosphomevalonate kinase [Streptomyces sp. ... 45 0.009
emb|CAD24421.1| mevalonate kinase [Paracoccus zeaxanthinifa... 45 0.011
ref|ZP_02919501.1| hypothetical protein STRINF_00343 [Strep... 45 0.011
ref|NP_691148.1| phosphomevalonate kinase [Oceanobacillus i... 45 0.012
ref|YP_001034340.1| Mevalonate kinase, putative [Streptococ... 45 0.012
ref|YP_814846.1| Mevalonate kinase [Lactobacillus gasseri A... 45 0.014
ref|ZP_03807562.1| mevalonate kinase [Lactobacillus jenseni... 45 0.014
ref|ZP_01273285.1| Gram positive phosphomevalonate kinase [... 44 0.017
ref|ZP_03974669.1| phosphomevalonate kinase [Lactobacillus ... 44 0.017
ref|ZP_02368550.1| mevalonate kinase, putative [Borrelia va... 44 0.019
ref|ZP_02193921.1| mevalonate kinase [Methanococcus voltae ... 44 0.020
ref|ZP_03937041.1| possible mevalonate kinase [Gardnerella ... 44 0.023
gb|AAG02435.1|AF290091_1 mevalonate kinase [Staphylococcus ... 44 0.024
ref|ZP_03895349.1| galactokinase [Eggerthella lenta DSM 224... 44 0.024
ref|ZP_03859053.1| mevalonate kinase [Thermobaculum terrenu... 44 0.024
ref|YP_187834.1| mevalonate kinase [Staphylococcus epidermi... 44 0.026
ref|ZP_03808267.1| mevalonate kinase [Lactobacillus gasseri... 44 0.026
ref|ZP_03954539.1| phosphomevalonate kinase [Lactobacillus ... 44 0.027
ref|ZP_03943396.1| phosphomevalonate kinase [Lactobacillus ... 44 0.029
gb|ABS50475.1| NapT6 [Streptomyces sp. CNQ525] 44 0.030
ref|YP_710139.1| mevalonate kinase, putative [Borrelia afze... 43 0.039
emb|CAL34097.1| putative mevalonate kinase [Streptomyces ci... 43 0.044
ref|YP_001324970.1| mevalonate kinase [Methanococcus aeolic... 43 0.048
ref|ZP_02529481.1| mevalonate kinase, putative [Borrelia af... 43 0.052
ref|ZP_03951014.1| mevalonate kinase [Lactobacillus gasseri... 42 0.064
ref|ZP_04021895.1| phosphomevalonate kinase [Lactobacillus ... 42 0.066
ref|YP_907150.1| mevalonate kinase, Erg12 [Mycobacterium ul... 42 0.068
ref|YP_804425.1| Phosphomevalonate kinase [Pediococcus pent... 42 0.073
ref|XP_001423293.1| hypothetical protein GSPATT00000330001 ... 42 0.076
ref|ZP_03940388.1| phosphomevalonate kinase [Lactobacillus ... 42 0.084
ref|YP_391999.1| GHMP kinase [Thiomicrospira crunogena XCL-... 42 0.092
ref|ZP_03898197.1| galactokinase [Dyadobacter fermentans DS... 42 0.10
ref|ZP_03956253.1| phosphomevalonate kinase [Lactobacillus ... 42 0.10
ref|ZP_03956255.1| mevalonate kinase [Lactobacillus jenseni... 42 0.11
ref|YP_073131.1| mevalonate kinase, putative [Borrelia gari... 42 0.11
ref|YP_795033.1| Mevalonate kinase [Lactobacillus brevis AT... 41 0.16
ref|NP_688324.1| mevalonate kinase, putative [Streptococcus... 41 0.18
>emb|CAA53059.1| unnamed protein product [Hepatitis B virus]
Length = 557
Score = 767 bits (1980), Expect = 0.0, Method: Composition-based stats.
Identities = 396/396 (100%), Positives = 396/396 (100%)
Query: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 60
MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR
Sbjct: 162 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 221
Query: 61 AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC 120
AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC
Sbjct: 222 AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC 281
Query: 121 RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE 180
RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE
Sbjct: 282 RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE 341
Query: 181 DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP 240
DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP
Sbjct: 342 DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP 401
Query: 241 RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM 300
RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM
Sbjct: 402 RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM 461
Query: 301 NQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL 360
NQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL
Sbjct: 462 NQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL 521
Query: 361 TSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL 396
TSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL
Sbjct: 522 TSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL 557
>ref|NP_000422.1| mevalonate kinase [Homo sapiens]
ref|NP_001107657.1| mevalonate kinase [Homo sapiens]
sp|Q03426|KIME_HUMAN Mevalonate kinase (MK)
gb|AAB59362.1| mevalonate kinase
emb|CAA53060.1| unnamed protein product [Homo sapiens]
gb|AAF82407.1| mevalonate kinase [Homo sapiens]
gb|AAH16140.1| MVK protein [Homo sapiens]
gb|EAW97872.1| mevalonate kinase (mevalonic aciduria), isoform CRA_c [Homo
sapiens]
gb|EAW97873.1| mevalonate kinase (mevalonic aciduria), isoform CRA_c [Homo
sapiens]
gb|ABM82015.1| mevalonate kinase (mevalonic aciduria) [synthetic construct]
gb|ABM85197.1| mevalonate kinase (mevalonic aciduria) [synthetic construct]
Length = 396
Score = 762 bits (1968), Expect = 0.0, Method: Composition-based stats.
Identities = 396/396 (100%), Positives = 396/396 (100%)
Query: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 60
MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR
Sbjct: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 60
Query: 61 AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC 120
AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC
Sbjct: 61 AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC 120
Query: 121 RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE 180
RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE
Sbjct: 121 RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE 180
Query: 181 DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP 240
DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP
Sbjct: 181 DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP 240
Query: 241 RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM 300
RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM
Sbjct: 241 RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM 300
Query: 301 NQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL 360
NQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL
Sbjct: 301 NQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL 360
Query: 361 TSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL 396
TSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL
Sbjct: 361 TSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL 396
>gb|AAQ02416.1| mevalonate kinase [synthetic construct]
Length = 397
Score = 761 bits (1966), Expect = 0.0, Method: Composition-based stats.
Identities = 396/396 (100%), Positives = 396/396 (100%)
Query: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 60
MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR
Sbjct: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 60
Query: 61 AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC 120
AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC
Sbjct: 61 AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC 120
Query: 121 RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE 180
RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE
Sbjct: 121 RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE 180
Query: 181 DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP 240
DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP
Sbjct: 181 DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP 240
Query: 241 RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM 300
RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM
Sbjct: 241 RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM 300
Query: 301 NQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL 360
NQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL
Sbjct: 301 NQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL 360
Query: 361 TSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL 396
TSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL
Sbjct: 361 TSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL 396
>dbj|BAD92959.1| mevalonate kinase variant [Homo sapiens]
Length = 421
Score = 761 bits (1965), Expect = 0.0, Method: Composition-based stats.
Identities = 395/396 (99%), Positives = 396/396 (100%)
Query: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 60
MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDL+LPNIGIKR
Sbjct: 26 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLNLPNIGIKR 85
Query: 61 AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC 120
AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC
Sbjct: 86 AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC 145
Query: 121 RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE 180
RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE
Sbjct: 146 RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE 205
Query: 181 DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP 240
DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP
Sbjct: 206 DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP 265
Query: 241 RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM 300
RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM
Sbjct: 266 RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM 325
Query: 301 NQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL 360
NQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL
Sbjct: 326 NQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL 385
Query: 361 TSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL 396
TSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL
Sbjct: 386 TSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL 421
>ref|XP_001105759.1| PREDICTED: mevalonate kinase isoform 2 [Macaca mulatta]
ref|XP_001105815.1| PREDICTED: mevalonate kinase isoform 3 [Macaca mulatta]
Length = 396
Score = 726 bits (1873), Expect = 0.0, Method: Composition-based stats.
Identities = 381/396 (96%), Positives = 383/396 (96%)
Query: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 60
MLSEVLLVSAPGKVILHGEHAVVHGKVALAV+LNLRTFLRLQPHSNGKVDLSLPNIGIK
Sbjct: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVALNLRTFLRLQPHSNGKVDLSLPNIGIKW 60
Query: 61 AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC 120
AWDVARLQ LDTSFLEQGD TTPT E VEKLKEVAGLPDDCAVTE LAVLAFLYLYLSIC
Sbjct: 61 AWDVARLQLLDTSFLEQGDATTPTPELVEKLKEVAGLPDDCAVTESLAVLAFLYLYLSIC 120
Query: 121 RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE 180
RKQRALPSLDIVVWSELP GAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGD VNRWTKE
Sbjct: 121 RKQRALPSLDIVVWSELPHGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDRVNRWTKE 180
Query: 181 DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP 240
DLELINKWAFQGER+IHGNPSGVDNAVSTWGGALRY QGKISSLKR PALQILLTNTKVP
Sbjct: 181 DLELINKWAFQGERVIHGNPSGVDNAVSTWGGALRYQQGKISSLKRPPALQILLTNTKVP 240
Query: 241 RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM 300
RNTR LVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM
Sbjct: 241 RNTRTLVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM 300
Query: 301 NQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL 360
NQHHLNALGVGHASLDQLCQVTRA GLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL
Sbjct: 301 NQHHLNALGVGHASLDQLCQVTRAHGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL 360
Query: 361 TSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL 396
TSCGFDC ETSIGAPGVSIHSATSLDSRVQQALDGL
Sbjct: 361 TSCGFDCWETSIGAPGVSIHSATSLDSRVQQALDGL 396
>ref|XP_543435.2| PREDICTED: similar to Mevalonate kinase (MK) [Canis familiaris]
Length = 409
Score = 639 bits (1648), Expect = 0.0, Method: Composition-based stats.
Identities = 335/400 (83%), Positives = 358/400 (89%), Gaps = 4/400 (1%)
Query: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 60
MLSEVLLVSAPGKVILHGEHAVVHGK+ALAV+LNLRTFLRLQPHSNGK+ L+LPNIG+KR
Sbjct: 10 MLSEVLLVSAPGKVILHGEHAVVHGKIALAVALNLRTFLRLQPHSNGKMCLNLPNIGVKR 69
Query: 61 AWDVARLQSLDTSFLE----QGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLY 116
AWDVARLQ DTSFLE GD PTSEQVEKLKEVAG+P D A E LAVLAFLYLY
Sbjct: 70 AWDVARLQLQDTSFLEPGNATGDAAAPTSEQVEKLKEVAGIPKDGADPECLAVLAFLYLY 129
Query: 117 LSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNR 176
LSICRKQR LPSLDI VWSELP GAGLGSSAAYSVCLAAALLT CE IPNP +G+ +R
Sbjct: 130 LSICRKQRTLPSLDITVWSELPTGAGLGSSAAYSVCLAAALLTACEAIPNPQNNGESASR 189
Query: 177 WTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTN 236
WT EDLELINKWAFQGERMIHGNPSGVDN +STWGGALRY QGKISS+KR PAL+ILLTN
Sbjct: 190 WTMEDLELINKWAFQGERMIHGNPSGVDNTISTWGGALRYQQGKISSIKRLPALKILLTN 249
Query: 237 TKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEE 296
TKVPR+T+ALVA VR+RLLKFPEIVAPLLTSI+AISLECER L EM APAPE YLVLEE
Sbjct: 250 TKVPRSTKALVASVRSRLLKFPEIVAPLLTSINAISLECERTLEEMASAPAPEHYLVLEE 309
Query: 297 LIDMNQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEAT 356
LID+NQHHLNALGVGHASLDQLCQVT A GLHSKLTGAGGGGCGITLL+P LEQP+VEA
Sbjct: 310 LIDINQHHLNALGVGHASLDQLCQVTMAHGLHSKLTGAGGGGCGITLLRPDLEQPKVEAM 369
Query: 357 KQALTSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL 396
KQALTSCGFDC ET IGAPG+SIHSA SLD++VQ+ALDGL
Sbjct: 370 KQALTSCGFDCWETRIGAPGISIHSAASLDTQVQRALDGL 409
>ref|NP_001015528.1| mevalonate kinase [Bos taurus]
sp|Q5E9T8|KIME_BOVIN Mevalonate kinase (MK)
gb|AAX08849.1| mevalonate kinase [Bos taurus]
gb|AAI04541.1| Mevalonate kinase (mevalonic aciduria) [Bos taurus]
Length = 396
Score = 632 bits (1630), Expect = e-179, Method: Composition-based stats.
Identities = 327/396 (82%), Positives = 352/396 (88%)
Query: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 60
MLSEVLLVSAPGKVILHGEHAVVHGKVALAV+LNLRTFLRLQPHSNG+V L+LPNIG++R
Sbjct: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVALNLRTFLRLQPHSNGRVGLNLPNIGVRR 60
Query: 61 AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC 120
AWDVA LQ LDTSFL GD T++ VEKLKEVAG P DC E LAVLAFLYLYLSIC
Sbjct: 61 AWDVASLQLLDTSFLGHGDSAALTAKHVEKLKEVAGFPKDCVDPEHLAVLAFLYLYLSIC 120
Query: 121 RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE 180
+ QRALPSLDI VWSELP GAGLGSSAAYSVCLAAALLT CEEIPNPLKDG+ RWT+E
Sbjct: 121 QSQRALPSLDITVWSELPTGAGLGSSAAYSVCLAAALLTACEEIPNPLKDGEAAGRWTEE 180
Query: 181 DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP 240
+LELINKWAFQGER+IHGNPSGVDNAVSTWGGALRY QGKISSLKR P L+ILL NTKVP
Sbjct: 181 NLELINKWAFQGERVIHGNPSGVDNAVSTWGGALRYQQGKISSLKRPPVLKILLINTKVP 240
Query: 241 RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM 300
R+T+ LVA VR+RLLKFPEIVAPLLTSIDAISLECERVLGEM AP PE YL LEELIDM
Sbjct: 241 RSTKVLVANVRSRLLKFPEIVAPLLTSIDAISLECERVLGEMAAAPTPEHYLTLEELIDM 300
Query: 301 NQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL 360
NQHHLNALGVGHASLDQLCQVT A GLHSKLTGAGGGGCGITLL+P +E+P VEATK+AL
Sbjct: 301 NQHHLNALGVGHASLDQLCQVTTAHGLHSKLTGAGGGGCGITLLRPDVERPAVEATKRAL 360
Query: 361 TSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL 396
+ CGFDC ETS+GAPGVS+H+A SLD+ VQQ LD L
Sbjct: 361 SGCGFDCWETSVGAPGVSVHTAASLDASVQQGLDSL 396
>gb|AAX08684.1| mevalonate kinase [Bos taurus]
Length = 396
Score = 630 bits (1626), Expect = e-179, Method: Composition-based stats.
Identities = 326/396 (82%), Positives = 351/396 (88%)
Query: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 60
MLSEVLLVSAPGKVILHGEHAVVHGKVALAV+LNLRTFLRLQPHSNG+V L+LPNIG++R
Sbjct: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVALNLRTFLRLQPHSNGRVGLNLPNIGVRR 60
Query: 61 AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC 120
AWDVA LQ LDTSFL GD T++ VEKLKEVAG P DC E LAVLAFLYLYLSIC
Sbjct: 61 AWDVASLQLLDTSFLGHGDSAALTAKHVEKLKEVAGFPKDCVDPEHLAVLAFLYLYLSIC 120
Query: 121 RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE 180
+ QR LPSLDI VWSELP GAGLGSSAAYSVCLAAALLT CEEIPNPLKDG+ RWT+E
Sbjct: 121 QSQRVLPSLDITVWSELPTGAGLGSSAAYSVCLAAALLTACEEIPNPLKDGEAAGRWTEE 180
Query: 181 DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP 240
+LELINKWAFQGER+IHGNPSGVDNAVSTWGGALRY QGKISSLKR P L+ILL NTKVP
Sbjct: 181 NLELINKWAFQGERVIHGNPSGVDNAVSTWGGALRYQQGKISSLKRPPVLKILLINTKVP 240
Query: 241 RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM 300
R+T+ LVA VR+RLLKFPEIVAPLLTSIDAISLECERVLGEM AP PE YL LEELIDM
Sbjct: 241 RSTKVLVANVRSRLLKFPEIVAPLLTSIDAISLECERVLGEMAAAPTPEHYLTLEELIDM 300
Query: 301 NQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL 360
NQHHLNALGVGHASLDQLCQVT A GLHSKLTGAGGGGCGITLL+P +E+P VEATK+AL
Sbjct: 301 NQHHLNALGVGHASLDQLCQVTTAHGLHSKLTGAGGGGCGITLLRPDVERPAVEATKRAL 360
Query: 361 TSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL 396
+ CGFDC ETS+GAPGVS+H+A SLD+ VQQ LD L
Sbjct: 361 SGCGFDCWETSVGAPGVSVHTAASLDASVQQGLDSL 396
>ref|XP_001496887.1| PREDICTED: similar to mevalonate kinase [Equus caballus]
Length = 407
Score = 621 bits (1602), Expect = e-176, Method: Composition-based stats.
Identities = 335/397 (84%), Positives = 360/397 (90%), Gaps = 1/397 (0%)
Query: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 60
MLSEVLLVSAPGKVILHGEHAVVHGKVALAV+LNLRTFLRLQPHS GKV L+LPNIGIK+
Sbjct: 11 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVALNLRTFLRLQPHSTGKVGLNLPNIGIKQ 70
Query: 61 AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTER-LAVLAFLYLYLSI 119
AWDVA LQ LDTSFLEQGD+T T EQVEKLKEVAG P+DCA + LAVLAFL+LYLSI
Sbjct: 71 AWDVASLQLLDTSFLEQGDITALTPEQVEKLKEVAGCPEDCANDHKWLAVLAFLFLYLSI 130
Query: 120 CRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTK 179
CRKQRALPSLD+ VWSELPPGAGLGSSAAYSVCLAAA L CEEIPNPLKDG+ +RWT+
Sbjct: 131 CRKQRALPSLDVTVWSELPPGAGLGSSAAYSVCLAAAFLAACEEIPNPLKDGEPTSRWTE 190
Query: 180 EDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKV 239
EDLELINKWAFQGER+IHGNPSGVDN VSTWGGALRY QGKISSLKR PAL+ILLTNTKV
Sbjct: 191 EDLELINKWAFQGERVIHGNPSGVDNTVSTWGGALRYQQGKISSLKRPPALKILLTNTKV 250
Query: 240 PRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELID 299
PR+T+ALVAGVRNRLLKFPEIVAP+LTSI+AISLECERVL EM AP P YLVLEELID
Sbjct: 251 PRSTKALVAGVRNRLLKFPEIVAPVLTSIEAISLECERVLAEMASAPTPGHYLVLEELID 310
Query: 300 MNQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQA 359
MNQHHLNALGVGHASLDQLCQVT A GLHSKLTG GGGGCGITLL+P L++ EVEA KQA
Sbjct: 311 MNQHHLNALGVGHASLDQLCQVTTAHGLHSKLTGGGGGGCGITLLRPDLQRLEVEAAKQA 370
Query: 360 LTSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL 396
LT CGFDC ETSIGAPGVS+H+ATSLD+ + QALDG+
Sbjct: 371 LTGCGFDCWETSIGAPGVSVHAATSLDAPILQALDGI 407
>ref|XP_001105689.1| PREDICTED: mevalonate kinase isoform 1 [Macaca mulatta]
Length = 344
Score = 607 bits (1565), Expect = e-172, Method: Composition-based stats.
Identities = 331/396 (83%), Positives = 333/396 (84%), Gaps = 52/396 (13%)
Query: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 60
MLSEVLLVSAPGKVILHGEHAVVHGKVALAV+LNLRTFLRLQPHSNGKVDLSLPNIGIK
Sbjct: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVALNLRTFLRLQPHSNGKVDLSLPNIGIKW 60
Query: 61 AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC 120
AWDVARLQ LDTSFLEQGD TTPT E VEKLKEVAGLPDDCAVTE LAVLAFLYLYLSIC
Sbjct: 61 AWDVARLQLLDTSFLEQGDATTPTPELVEKLKEVAGLPDDCAVTESLAVLAFLYLYLSIC 120
Query: 121 RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE 180
RKQ RWTKE
Sbjct: 121 RKQ----------------------------------------------------RWTKE 128
Query: 181 DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP 240
DLELINKWAFQGER+IHGNPSGVDNAVSTWGGALRY QGKISSLKR PALQILLTNTKVP
Sbjct: 129 DLELINKWAFQGERVIHGNPSGVDNAVSTWGGALRYQQGKISSLKRPPALQILLTNTKVP 188
Query: 241 RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM 300
RNTR LVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM
Sbjct: 189 RNTRTLVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM 248
Query: 301 NQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL 360
NQHHLNALGVGHASLDQLCQVTRA GLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL
Sbjct: 249 NQHHLNALGVGHASLDQLCQVTRAHGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL 308
Query: 361 TSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL 396
TSCGFDC ETSIGAPGVSIHSATSLDSRVQQALDGL
Sbjct: 309 TSCGFDCWETSIGAPGVSIHSATSLDSRVQQALDGL 344
>gb|AAX46713.1| mevalonate kinase [Bos taurus]
Length = 440
Score = 603 bits (1555), Expect = e-171, Method: Composition-based stats.
Identities = 314/379 (82%), Positives = 338/379 (89%)
Query: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 60
MLSE LLVSAPGKVILHGEHAVVHGKVALA++LNLRTFLRLQPHSNG+V L+LPNIG++R
Sbjct: 1 MLSEALLVSAPGKVILHGEHAVVHGKVALAMALNLRTFLRLQPHSNGRVGLNLPNIGVRR 60
Query: 61 AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC 120
AWDVA LQ LDTSFL GD T++ VEKLKEVAG P DC E LAVLAFLYLYLSIC
Sbjct: 61 AWDVASLQLLDTSFLGHGDSAALTAKHVEKLKEVAGFPKDCVDPEHLAVLAFLYLYLSIC 120
Query: 121 RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE 180
+ QRALPSLDI VWSELP GAGLGSSAAYSVCLAAALLT CEEIPNPLKDG+ RWT+E
Sbjct: 121 QSQRALPSLDITVWSELPTGAGLGSSAAYSVCLAAALLTACEEIPNPLKDGEAAGRWTEE 180
Query: 181 DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP 240
+LELINKWAFQGER+IHGNPSGVDNAVSTWGGALRY QGKISSLKR P L+ILL NTKVP
Sbjct: 181 NLELINKWAFQGERVIHGNPSGVDNAVSTWGGALRYQQGKISSLKRPPVLKILLINTKVP 240
Query: 241 RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM 300
R+T+ LVA VR+RLLKFPEIVAPLLTSIDAISLECERVLGEM AP PE YL LEELIDM
Sbjct: 241 RSTKVLVANVRSRLLKFPEIVAPLLTSIDAISLECERVLGEMAAAPTPEHYLTLEELIDM 300
Query: 301 NQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL 360
NQHHLNALGVGHASLDQLCQVT A GLHSKLTGAGGGGCGITLL+P +E+PEVEATK+AL
Sbjct: 301 NQHHLNALGVGHASLDQLCQVTTAHGLHSKLTGAGGGGCGITLLRPDVERPEVEATKRAL 360
Query: 361 TSCGFDCLETSIGAPGVSI 379
+ GFDC ETS+GAPGVS+
Sbjct: 361 SGYGFDCWETSVGAPGVSV 379
>ref|NP_112325.1| mevalonate kinase [Rattus norvegicus]
sp|P17256|KIME_RAT Mevalonate kinase (MK)
pdb|1KVK|A Chain A, The Structure Of Binary Complex Between A Mammalian
Mevalonate Kinase And Atp: Insights Into The Reaction
Mechanism And Human Inherited Disease
gb|AAA41588.1| mevalonate kinase (EC 2.7.1.36)
gb|EDM13937.1| mevalonate kinase, isoform CRA_a [Rattus norvegicus]
Length = 395
Score = 596 bits (1536), Expect = e-168, Method: Composition-based stats.
Identities = 322/393 (81%), Positives = 355/393 (90%)
Query: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 60
MLSEVLLVSAPGKVILHGEHAVVHGKVALAV+LNLRTFL L+P SNGKV L+LPN+GIK+
Sbjct: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVALNLRTFLVLRPQSNGKVSLNLPNVGIKQ 60
Query: 61 AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC 120
WDVA LQ LDT FLEQGDV PT EQ+EKLK+VAGLP DC E L++LAFLYLYL+IC
Sbjct: 61 VWDVATLQLLDTGFLEQGDVPAPTLEQLEKLKKVAGLPRDCVGNEGLSLLAFLYLYLAIC 120
Query: 121 RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE 180
RKQR LPSLDI+VWSELPPGAGLGSSAAYSVC+AAALLT CEE+ NPLKD + W +E
Sbjct: 121 RKQRTLPSLDIMVWSELPPGAGLGSSAAYSVCVAAALLTACEEVTNPLKDRGSIGSWPEE 180
Query: 181 DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP 240
DL+ INKWA++GER+IHGNPSGVDN+VSTWGGALRY QGK+SSLKR PALQILLTNTKVP
Sbjct: 181 DLKSINKWAYEGERVIHGNPSGVDNSVSTWGGALRYQQGKMSSLKRLPALQILLTNTKVP 240
Query: 241 RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM 300
R+T+ALVAGVR+RL+KFPEI+APLLTSIDAISLECERVLGEM AP PEQYLVLEEL+DM
Sbjct: 241 RSTKALVAGVRSRLIKFPEIMAPLLTSIDAISLECERVLGEMAAAPVPEQYLVLEELMDM 300
Query: 301 NQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL 360
NQHHLNALGVGHASLDQLCQVT A GLHSKLTGAGGGGCGITLLKPGLE+ +VEA KQAL
Sbjct: 301 NQHHLNALGVGHASLDQLCQVTAAHGLHSKLTGAGGGGCGITLLKPGLERAKVEAAKQAL 360
Query: 361 TSCGFDCLETSIGAPGVSIHSATSLDSRVQQAL 393
T CGFDC ETSIGAPGVS+HSATS++ V+QAL
Sbjct: 361 TGCGFDCWETSIGAPGVSMHSATSIEDPVRQAL 393
>ref|NP_076045.1| mevalonate kinase [Mus musculus]
sp|Q9R008|KIME_MOUSE Mevalonate kinase (MK)
gb|AAF00700.1|AF137598_1 mevalonate kinase [Mus musculus]
gb|AAH05606.1| Mevalonate kinase [Mus musculus]
Length = 395
Score = 582 bits (1501), Expect = e-164, Method: Composition-based stats.
Identities = 319/393 (81%), Positives = 347/393 (88%)
Query: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 60
MLSE LLVSAPGKVILHGEHAVVHGKVALA +LNLRTFL L+P SNGKV ++LPNIGIK+
Sbjct: 1 MLSEALLVSAPGKVILHGEHAVVHGKVALAAALNLRTFLLLRPQSNGKVSVNLPNIGIKQ 60
Query: 61 AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC 120
WDV LQ LDTSFLEQGDV+ PT EQ+EKLK++ LP D A E +A+LAFLYLYL+IC
Sbjct: 61 VWDVGMLQRLDTSFLEQGDVSVPTLEQLEKLKKMGDLPRDRAGNEGMALLAFLYLYLAIC 120
Query: 121 RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE 180
RKQR LPSLD+VVWSELPPGAGLGSSAAYSVCLAAALLT CEE+ NPLKDG V+RW +E
Sbjct: 121 RKQRTLPSLDMVVWSELPPGAGLGSSAAYSVCLAAALLTACEEVSNPLKDGVSVSRWPEE 180
Query: 181 DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP 240
DL+ INKWAF+GER+IHGNPSGVDNAVSTWGGALR+ QG +SSLK P+LQILLTNTKVP
Sbjct: 181 DLKSINKWAFEGERVIHGNPSGVDNAVSTWGGALRFQQGTMSSLKSLPSLQILLTNTKVP 240
Query: 241 RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM 300
R+T+ALVA VR+RL KFPEIVAPLLTSIDAISLECERVLGEM AP PEQYLVLEELIDM
Sbjct: 241 RSTKALVAAVRSRLTKFPEIVAPLLTSIDAISLECERVLGEMVAAPVPEQYLVLEELIDM 300
Query: 301 NQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL 360
NQHHLNALGVGH SLDQLCQVT A GLHSKLTGAGGGGCGITLLKPGLEQ VEA KQAL
Sbjct: 301 NQHHLNALGVGHNSLDQLCQVTAAHGLHSKLTGAGGGGCGITLLKPGLEQATVEAAKQAL 360
Query: 361 TSCGFDCLETSIGAPGVSIHSATSLDSRVQQAL 393
TSCGFDC ETSIGAPGVS HSA ++ V+QAL
Sbjct: 361 TSCGFDCWETSIGAPGVSTHSAAAVGDPVRQAL 393
>dbj|BAE28997.1| unnamed protein product [Mus musculus]
Length = 407
Score = 573 bits (1478), Expect = e-162, Method: Composition-based stats.
Identities = 319/405 (78%), Positives = 347/405 (85%), Gaps = 12/405 (2%)
Query: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 60
MLSE LLVSAPGKVILHGEHAVVHGKVALA +LNLRTFL L+P SNGKV ++LPNIGIK+
Sbjct: 1 MLSEALLVSAPGKVILHGEHAVVHGKVALAAALNLRTFLLLRPQSNGKVSVNLPNIGIKQ 60
Query: 61 AWDVARLQSLDTSFL------------EQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLA 108
WDV LQ LDTSFL EQGDV+ PT EQ+EKLK++ LP D A E +A
Sbjct: 61 VWDVGMLQRLDTSFLGLSPTCLFARVTEQGDVSVPTLEQLEKLKKMGDLPRDRAGNEGMA 120
Query: 109 VLAFLYLYLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPL 168
+LAFLYLYL+ICRKQR LPSLD+VVWSELPPGAGLGSSAAYSVCLAAALLT CEE+ NPL
Sbjct: 121 LLAFLYLYLAICRKQRTLPSLDMVVWSELPPGAGLGSSAAYSVCLAAALLTACEEVSNPL 180
Query: 169 KDGDCVNRWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSP 228
KDG V+RW +EDL+ INKWAF+GER+IHGNPSGVDNAVSTWGGALR+ QG +SSLK P
Sbjct: 181 KDGVSVSRWPEEDLKSINKWAFEGERVIHGNPSGVDNAVSTWGGALRFQQGTMSSLKSLP 240
Query: 229 ALQILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAP 288
+LQILLTNTKVPR+T+ALVA VR+RL KFPEIVAPLLTSIDAISLECERVLGEM AP P
Sbjct: 241 SLQILLTNTKVPRSTKALVAAVRSRLTKFPEIVAPLLTSIDAISLECERVLGEMVAAPVP 300
Query: 289 EQYLVLEELIDMNQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGL 348
EQYLVLEELIDMNQHHLNALGVGH SLDQLCQVT A GLHSKLTGAGGGGCGITLLKPGL
Sbjct: 301 EQYLVLEELIDMNQHHLNALGVGHNSLDQLCQVTAAHGLHSKLTGAGGGGCGITLLKPGL 360
Query: 349 EQPEVEATKQALTSCGFDCLETSIGAPGVSIHSATSLDSRVQQAL 393
EQ VEA KQALTSCGFDC ETSIGAPGVS HSA ++ V+QAL
Sbjct: 361 EQATVEAAKQALTSCGFDCWETSIGAPGVSTHSAAAVGDPVRQAL 405
>ref|XP_001364115.1| PREDICTED: similar to mevalonate kinase [Monodelphis domestica]
Length = 396
Score = 551 bits (1420), Expect = e-155, Method: Composition-based stats.
Identities = 287/396 (72%), Positives = 327/396 (82%)
Query: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 60
ML E LLVSAPGKVILHGEHAVVHGKVALA +LNLRTFLR++PH +GKV L LPN+ R
Sbjct: 1 MLPETLLVSAPGKVILHGEHAVVHGKVALAEALNLRTFLRMRPHKDGKVRLVLPNLETSR 60
Query: 61 AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC 120
WDV++LQ L SFL+ G+ T PT+EQVEKLK AG + E LAVLAFLYLYL IC
Sbjct: 61 EWDVSKLQLLHASFLDSGEPTAPTTEQVEKLKAFAGFMTGSSERECLAVLAFLYLYLFIC 120
Query: 121 RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE 180
RK R LPS+DIVVWSELP GAGLGSSAAYSVCLAAALL CEEI N LK+G RW ++
Sbjct: 121 RKHRPLPSMDIVVWSELPTGAGLGSSAAYSVCLAAALLASCEEIMNRLKEGATSARWNED 180
Query: 181 DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP 240
+L LIN+WAF GE++IHGNPSGVDN+VSTWGGALR+ +G ISSL+R P L+ILLTNTKVP
Sbjct: 181 ELNLINRWAFLGEKVIHGNPSGVDNSVSTWGGALRFQKGNISSLQRIPVLKILLTNTKVP 240
Query: 241 RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM 300
R+T+ALVA V++RL KFPEI+ PLL SIDAIS ECERVLG M P PEQY+VLEELIDM
Sbjct: 241 RSTKALVASVKDRLAKFPEIMNPLLVSIDAISQECERVLGVMAATPTPEQYMVLEELIDM 300
Query: 301 NQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL 360
NQHHLNA+GVGH+SLD+LCQVT A GLHSKLTGAGGGGCG TLL+PGL+Q VEA KQAL
Sbjct: 301 NQHHLNAIGVGHSSLDRLCQVTAAHGLHSKLTGAGGGGCGFTLLRPGLDQSVVEAIKQAL 360
Query: 361 TSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL 396
TSCGF+C ET+IG PGVS+HS SL + V QAL+ L
Sbjct: 361 TSCGFECWETTIGGPGVSLHSEASLKANVLQALNSL 396
>ref|XP_918559.1| PREDICTED: similar to mevalonate kinase [Mus musculus]
Length = 382
Score = 513 bits (1322), Expect = e-144, Method: Composition-based stats.
Identities = 286/367 (77%), Positives = 316/367 (86%)
Query: 27 VALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKRAWDVARLQSLDTSFLEQGDVTTPTSE 86
VALA +LNLRTFL L+P SNGKV ++LPNIGIK+ WDV LQ LDTSFLEQGDV+ PT E
Sbjct: 14 VALAAALNLRTFLLLRPQSNGKVSVNLPNIGIKQVWDVGMLQRLDTSFLEQGDVSVPTLE 73
Query: 87 QVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSICRKQRALPSLDIVVWSELPPGAGLGSS 146
Q+EKLK++ LP D A E +A+LAFLYLYL+ICRKQR LPSLD+VVWSELPPGAGLGSS
Sbjct: 74 QLEKLKKMGDLPRDRAGNEGMALLAFLYLYLAICRKQRTLPSLDMVVWSELPPGAGLGSS 133
Query: 147 AAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKEDLELINKWAFQGERMIHGNPSGVDNA 206
AAYSVCLAAALLT CEE+ NPLKDG V+RW +EDL+ INKWAF+GER+IHGNPSGVDNA
Sbjct: 134 AAYSVCLAAALLTACEEVSNPLKDGVSVSRWPEEDLKSINKWAFEGERVIHGNPSGVDNA 193
Query: 207 VSTWGGALRYHQGKISSLKRSPALQILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLT 266
+STWG ++ + S L R P+LQILLTNTKVPR+T+ALVA VR+RL KFPEIVAPLLT
Sbjct: 194 ISTWGKSVCSLSSRESRLSRLPSLQILLTNTKVPRSTKALVAAVRSRLTKFPEIVAPLLT 253
Query: 267 SIDAISLECERVLGEMGEAPAPEQYLVLEELIDMNQHHLNALGVGHASLDQLCQVTRARG 326
SIDAISLECERVLGEM AP PEQYLVLEELIDMNQHHLNALGVGH SLDQLCQVT A G
Sbjct: 254 SIDAISLECERVLGEMVAAPVPEQYLVLEELIDMNQHHLNALGVGHNSLDQLCQVTAAHG 313
Query: 327 LHSKLTGAGGGGCGITLLKPGLEQPEVEATKQALTSCGFDCLETSIGAPGVSIHSATSLD 386
LHSKLTGAGGGGCGITLLKPGLEQ VEA KQALTSCGFDC ETSIGAPGVS HSA ++
Sbjct: 314 LHSKLTGAGGGGCGITLLKPGLEQATVEAAKQALTSCGFDCWETSIGAPGVSTHSAAAVG 373
Query: 387 SRVQQAL 393
V+QAL
Sbjct: 374 DPVRQAL 380
>emb|CAM15186.1| novel protein similar to vertebrate mevalonate kinase (mevalonic
aciduria) (MVK) [Danio rerio]
Length = 396
Score = 419 bits (1076), Expect = e-115, Method: Composition-based stats.
Identities = 224/396 (56%), Positives = 294/396 (74%), Gaps = 4/396 (1%)
Query: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 60
M S L VSAPGKVILHGEH+VVHGKVALAVS+NLRT+LRLQ S+G+V ++LPNI
Sbjct: 1 MQSRELFVSAPGKVILHGEHSVVHGKVALAVSVNLRTYLRLQSTSSGQVCINLPNIDTFL 60
Query: 61 AWDVARLQSL-DTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSI 119
+W++ LQ L S EQ D ++ ++KL+E G+ DD T +AVLAFLY+Y+++
Sbjct: 61 SWEITALQPLLAGSKAEQRDPKELDADLLKKLREFTGISDDSTDTRSMAVLAFLYMYITV 120
Query: 120 CRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTK 179
+ +L S+ + VWSELP GAGLGSSAAY+VCL+AALL+ I L RW+K
Sbjct: 121 FAE--SLASITVSVWSELPTGAGLGSSAAYNVCLSAALLSARGNISPLLMAQQESARWSK 178
Query: 180 EDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKV 239
+++ELIN+WAF GE++IHGNPSGVDNAV TWGG LRYH G I+ L P L+ILLTNTKV
Sbjct: 179 DEMELINRWAFMGEKIIHGNPSGVDNAVGTWGGFLRYHSGNITPLSWVPILRILLTNTKV 238
Query: 240 PRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGE-APAPEQYLVLEELI 298
PR+T+ LV+GV++++ KFP ++ P+L S+ A+S CE+ L EM E P+ E Y +LEELI
Sbjct: 239 PRSTKVLVSGVKDKINKFPSVMRPVLESVSAVSCTCEQTLTEMAEHGPSAEHYNILEELI 298
Query: 299 DMNQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQ 358
D+NQHHLN +GVGH+SLD LC+VT ++GLHSKLTGAGGGGCGITLL+P + +++T +
Sbjct: 299 DINQHHLNVMGVGHSSLDTLCRVTLSKGLHSKLTGAGGGGCGITLLRPETDTSVIQSTVE 358
Query: 359 ALTSCGFDCLETSIGAPGVSIHSATSLDSRVQQALD 394
L +CGFDC ETSIGAPGV HS+ ++ V + L+
Sbjct: 359 ELKACGFDCWETSIGAPGVQQHSSAAISPDVLKILN 394
>ref|NP_001007350.1| hypothetical protein LOC492477 [Danio rerio]
gb|AAH85528.1| Zgc:103473 [Danio rerio]
gb|AAI64491.1| Zgc:103473 protein [synthetic construct]
Length = 396
Score = 417 bits (1073), Expect = e-115, Method: Composition-based stats.
Identities = 224/396 (56%), Positives = 293/396 (73%), Gaps = 4/396 (1%)
Query: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 60
M S L VSAPGKVILHGEH+VVHGKVALAVS+NLRT+LRLQ S+G+V ++LPNI
Sbjct: 1 MQSRELFVSAPGKVILHGEHSVVHGKVALAVSVNLRTYLRLQSTSSGQVCINLPNIDTFL 60
Query: 61 AWDVARLQSL-DTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSI 119
+W++ LQ L S EQ D ++ ++KL+E G+ DD T +AVLAFLY+YL++
Sbjct: 61 SWEITALQPLLAGSKAEQRDPKELDADLLKKLREFTGISDDSTDTRSMAVLAFLYMYLTV 120
Query: 120 CRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTK 179
+ +L S+ + VWSELP GAGLGSSAAY+VCL+AALL+ I L RW+K
Sbjct: 121 FAE--SLASITVSVWSELPTGAGLGSSAAYNVCLSAALLSARGNISPLLMAQQESARWSK 178
Query: 180 EDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKV 239
+++ELIN+WAF GE++IHGNPSGVDNAV TWGG LRYH G I+ L P L+ILLTNTKV
Sbjct: 179 DEMELINRWAFMGEKIIHGNPSGVDNAVGTWGGFLRYHSGNITPLSWVPILRILLTNTKV 238
Query: 240 PRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGE-APAPEQYLVLEELI 298
PR+T+ LV+GV++++ KFP ++ P+L S+ A+S CE+ L EM E P+ E Y +LEELI
Sbjct: 239 PRSTKVLVSGVKDKINKFPSVMRPVLESVSAVSCTCEQTLTEMAEHGPSAEHYNILEELI 298
Query: 299 DMNQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQ 358
D+NQHHLN +GVGH+SLD LC+VT ++GLHSKLTGAGGGGCGITLL+P + +++ +
Sbjct: 299 DINQHHLNVMGVGHSSLDTLCRVTLSKGLHSKLTGAGGGGCGITLLRPETDTSVIQSAVE 358
Query: 359 ALTSCGFDCLETSIGAPGVSIHSATSLDSRVQQALD 394
L +CGFDC ETSIGAPGV HS+ ++ V + L+
Sbjct: 359 ELKACGFDCWETSIGAPGVQQHSSAAISPDVLKILN 394
>gb|AAX46707.1| mevalonate kinase [Bos taurus]
Length = 363
Score = 414 bits (1063), Expect = e-114, Method: Composition-based stats.
Identities = 207/253 (81%), Positives = 223/253 (88%)
Query: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 60
MLSEVLLVSAPGKVILHGEHAVVHGKVALAV+LNLRTFLRLQPHSNG+V L+LPNIG++R
Sbjct: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVALNLRTFLRLQPHSNGRVGLNLPNIGVRR 60
Query: 61 AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC 120
AWDVA LQ LDTSFL GD T++ VEKLKEVAG P DC E LAVLAFLYLYLSIC
Sbjct: 61 AWDVASLQLLDTSFLGHGDSAALTAKHVEKLKEVAGFPKDCVDPEHLAVLAFLYLYLSIC 120
Query: 121 RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE 180
+ QR LPSLDI VWSELP GAGLGSSAAYSVCLAAALLT CEEIPNPLKDG+ RWT+E
Sbjct: 121 QSQRVLPSLDITVWSELPTGAGLGSSAAYSVCLAAALLTACEEIPNPLKDGEAAGRWTEE 180
Query: 181 DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP 240
+LELINKWAFQGER+IHGNPSGVDNAVSTWGGALRY QGKISSLKR P L+ILL NTKVP
Sbjct: 181 NLELINKWAFQGERVIHGNPSGVDNAVSTWGGALRYQQGKISSLKRPPVLKILLINTKVP 240
Query: 241 RNTRALVAGVRNR 253
R+T+ LVA VR+R
Sbjct: 241 RSTKVLVANVRSR 253
>emb|CAG08527.1| unnamed protein product [Tetraodon nigroviridis]
Length = 394
Score = 399 bits (1024), Expect = e-109, Method: Composition-based stats.
Identities = 223/390 (57%), Positives = 275/390 (70%), Gaps = 3/390 (0%)
Query: 6 LLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKRAWDVA 65
+ VSAPGK ILHGEHAVVHGKVALAVSLNLR++LRL+ S G V ++LPNI W+++
Sbjct: 6 IYVSAPGKAILHGEHAVVHGKVALAVSLNLRSYLRLEATSTGTVGVNLPNIDTFLHWNLS 65
Query: 66 RLQSLDTSFLE-QGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSICRKQR 124
L+ S G V + + +L+E G+ + T ++A L FLYLYLS
Sbjct: 66 ELKQFAPSVTGGTGQVKLLDPDLLRRLREYVGVANGNLNTSQMATLTFLYLYLS-AFGSG 124
Query: 125 ALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKEDLEL 184
LPSL + VWSELP GAGLGSSAAY+VCLAAALL I +PLK+ + RW +E+LEL
Sbjct: 125 ELPSLTVSVWSELPTGAGLGSSAAYTVCLAAALLCASGAISSPLKEWEHTARWCQEELEL 184
Query: 185 INKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVPRNTR 244
IN WAFQGE +IHGNPSGVDNAV TWGG LR+ GKI L R P L+ILLTNTKVPR+T+
Sbjct: 185 INSWAFQGEMIIHGNPSGVDNAVGTWGGMLRFLAGKIIPLSRVPLLRILLTNTKVPRSTK 244
Query: 245 ALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAP-APEQYLVLEELIDMNQH 303
LV+ V++++ KFP ++AP+L S+DAIS CE+VL EM P E Y LEELID+NQH
Sbjct: 245 VLVSRVKDKINKFPSVMAPVLDSVDAISCTCEKVLSEMTSEPITGEHYNALEELIDINQH 304
Query: 304 HLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQALTSC 363
HLN +GVGH +LD LC++T +GLHSKLTGAGGGGCGITLL+P V+AT Q L C
Sbjct: 305 HLNVMGVGHPALDTLCRITLTKGLHSKLTGAGGGGCGITLLRPETGSAVVQATVQDLKDC 364
Query: 364 GFDCLETSIGAPGVSIHSATSLDSRVQQAL 393
GFDC ETSIG PGV H+ S+ + + L
Sbjct: 365 GFDCWETSIGGPGVQQHAPVSVKEEILEVL 394
>gb|EAW97870.1| mevalonate kinase (mevalonic aciduria), isoform CRA_a [Homo
sapiens]
Length = 202
Score = 377 bits (967), Expect = e-102, Method: Composition-based stats.
Identities = 202/202 (100%), Positives = 202/202 (100%)
Query: 195 MIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVPRNTRALVAGVRNRL 254
MIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVPRNTRALVAGVRNRL
Sbjct: 1 MIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVPRNTRALVAGVRNRL 60
Query: 255 LKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDMNQHHLNALGVGHAS 314
LKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDMNQHHLNALGVGHAS
Sbjct: 61 LKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDMNQHHLNALGVGHAS 120
Query: 315 LDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQALTSCGFDCLETSIGA 374
LDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQALTSCGFDCLETSIGA
Sbjct: 121 LDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQALTSCGFDCLETSIGA 180
Query: 375 PGVSIHSATSLDSRVQQALDGL 396
PGVSIHSATSLDSRVQQALDGL
Sbjct: 181 PGVSIHSATSLDSRVQQALDGL 202
>gb|ABR68258.1| mevalonate kinase [Monodelphis domestica]
Length = 253
Score = 373 bits (957), Expect = e-101, Method: Composition-based stats.
Identities = 192/252 (76%), Positives = 218/252 (86%)
Query: 126 LPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKEDLELI 185
LPS+DIVVWSELP GAGLGSSAAYSVCLAAALL CEEI N LK+G RW +++L LI
Sbjct: 2 LPSMDIVVWSELPTGAGLGSSAAYSVCLAAALLASCEEIMNRLKEGATSARWNEDELNLI 61
Query: 186 NKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVPRNTRA 245
N+WAF GE++IHGNPSGVDN+VSTWGGALR+ +G ISSL+R P L+ILLTNTKVPR+T+A
Sbjct: 62 NRWAFLGEKVIHGNPSGVDNSVSTWGGALRFQKGNISSLQRIPVLKILLTNTKVPRSTKA 121
Query: 246 LVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDMNQHHL 305
LVA V++RL KFPEI+ PLL SIDAIS ECERVLG M P PEQY+VLEELIDMNQHHL
Sbjct: 122 LVASVKDRLAKFPEIMNPLLVSIDAISQECERVLGVMAATPTPEQYMVLEELIDMNQHHL 181
Query: 306 NALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQALTSCGF 365
NA+GVGH+SLD+LCQVT A GLHSKLTGAGGGGCG TLL+PGL+Q VEA KQALTSCGF
Sbjct: 182 NAIGVGHSSLDRLCQVTAAHGLHSKLTGAGGGGCGFTLLRPGLDQSVVEAIKQALTSCGF 241
Query: 366 DCLETSIGAPGV 377
+C ET+IG PGV
Sbjct: 242 ECWETTIGGPGV 253
>ref|XP_790690.1| PREDICTED: similar to Mevalonate kinase (MK) [Strongylocentrotus
purpuratus]
ref|XP_001200159.1| PREDICTED: similar to Mevalonate kinase (MK) [Strongylocentrotus
purpuratus]
Length = 413
Score = 331 bits (849), Expect = 5e-89, Method: Composition-based stats.
Identities = 179/385 (46%), Positives = 252/385 (65%), Gaps = 14/385 (3%)
Query: 6 LLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKRAWDVA 65
+ +SAPGK+ILHGEHAVVHGK ALA LNLR++L L+ +G++ L+LP+I ++R+WDV
Sbjct: 16 IFISAPGKIILHGEHAVVHGKTALAAGLNLRSYLCLKEKDSGRLHLNLPDIDLERSWDVL 75
Query: 66 RLQS-----LDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC 120
LQ L++ +E P+ E +++L+ G D T+RLAV+AFLYLYL I
Sbjct: 76 ELQEQFRDLLNSDVME----VKPSVEIMQRLRLFLGY-SDTETTKRLAVMAFLYLYLCIA 130
Query: 121 RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE 180
+ P LD +V S LPPGAGLGSSAA+SVCLAA LLT + I PL D W++E
Sbjct: 131 GRNGKFPILDTLVSSALPPGAGLGSSAAFSVCLAAGLLTWAKAII-PLSLSDNTLDWSRE 189
Query: 181 DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP 240
D+ELIN WA++GER+IHGNPSG+DN++S GGA+ Y Q I+ L+ P L ILL NT V
Sbjct: 190 DMELINTWAYEGERVIHGNPSGIDNSISVHGGAIEYRQKVITPLENMPELSILLVNTCVA 249
Query: 241 RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQ---YLVLEEL 297
R+T+ LVAGV+ R K+P++ P+L SI+ IS EC+R L + + ++ + L EL
Sbjct: 250 RSTKELVAGVQRRHDKYPKVYGPILDSIEEISQECKRTLQALKTGESLDKDGAFKSLGEL 309
Query: 298 IDMNQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATK 357
+D+NQ L +GV H +++ + + A +H+KLTGAGGGGC LL P + + V+A +
Sbjct: 310 VDINQQLLYVIGVSHPAINNIVRSAAAYKIHAKLTGAGGGGCVFALLPPDIPKDSVKALQ 369
Query: 358 QALTSCGFDCLETSIGAPGVSIHSA 382
L ++ TS+GA GV +H +
Sbjct: 370 ADLFRHNYESWITSLGAHGVMMHRS 394
>ref|XP_001628178.1| predicted protein [Nematostella vectensis]
gb|EDO36115.1| predicted protein [Nematostella vectensis]
Length = 415
Score = 289 bits (740), Expect = 2e-76, Method: Composition-based stats.
Identities = 167/416 (40%), Positives = 243/416 (58%), Gaps = 43/416 (10%)
Query: 6 LLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSN-GKVDLSLPNIGIKRAWDV 64
++VSAPGK+ILHGEHAVV+GK A+AVS+ LRT + LQ H N KV L L ++ WD+
Sbjct: 6 VVVSAPGKIILHGEHAVVYGKAAIAVSIGLRTTVVLQRHKNESKVSLLLKDLDYILTWDL 65
Query: 65 ARLQSLDTSF--LEQGDVTTPTSEQVE---------KLKEVAGLPDDCAVTERLAVLAFL 113
+Q + + + + D P+ E + K EV G+ D A FL
Sbjct: 66 TDIQKILVAVPQVSRTDTVLPSDEMLSLIDKLIDSSKFVEVEGVKD--------AARVFL 117
Query: 114 YLYLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNP------ 167
+L S R + LP++++ V + LP GAGLGSSAAYS+ LAAA+L + IP P
Sbjct: 118 FLMTSTLRDRDRLPAIEVEVKTALPLGAGLGSSAAYSISLAAAMLLSMQTIPLPKYVKKT 177
Query: 168 ------LKDGDCV--NRWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQG 219
KD D + E L L+ +WAF+ E+++HG PSG+DN+++T+GGAL + G
Sbjct: 178 PESETTAKDTDSYQYDDIETESLRLVCQWAFEAEKIMHGQPSGIDNSIATYGGALLFQNG 237
Query: 220 KISSLKRSPALQILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVL 279
+I+ L+ P L ILL +T++PR+TR +VAGVR+R ++FP + L ++D I EC ++
Sbjct: 238 EITHLESMPLLSILLIDTQIPRSTRVMVAGVRDRYIEFPTVYMSLFEAVDGICHECIKIF 297
Query: 280 GEMG-----EAPAPE---QYLVLEELIDMNQHHLNALGVGHASLDQLCQVTRARGLHSKL 331
++ + P E Y LE L+D+NQ L+ GV H SLD LC +T GLH+KL
Sbjct: 298 SKIHNLKNEDVPKSEFVRYYQRLESLVDVNQQLLSLFGVSHPSLDSLCHMTSKYGLHTKL 357
Query: 332 TGAGGGGCGITLLKPGLEQPEV-EATKQALTSCGFDCLETSIGAPGVSIHSATSLD 386
TGAGGGGC ITL+ PG ++ +V E + + +T +G+ GV +H A +D
Sbjct: 358 TGAGGGGCAITLIPPGTDKDKVAELMNKLQKEFKYKVWQTPLGSRGVIVHEAIPVD 413
>gb|EDL19907.1| mevalonate kinase, isoform CRA_a [Mus musculus]
gb|EDL19908.1| mevalonate kinase, isoform CRA_a [Mus musculus]
Length = 221
Score = 266 bits (681), Expect = 2e-69, Method: Composition-based stats.
Identities = 149/214 (69%), Positives = 169/214 (78%), Gaps = 17/214 (7%)
Query: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 60
MLSE LLVS VALA +LNLRTFL L+P SNGKV ++LPNIGIK+
Sbjct: 1 MLSEALLVS-----------------VALAAALNLRTFLLLRPQSNGKVSVNLPNIGIKQ 43
Query: 61 AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC 120
WDV LQ LDTSFLEQGDV+ PT EQ+EKLK++ LP D A E +A+LAFLYLYL+IC
Sbjct: 44 VWDVGMLQRLDTSFLEQGDVSVPTLEQLEKLKKMGDLPRDRAGNEGMALLAFLYLYLAIC 103
Query: 121 RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE 180
RKQR LPSLD+VVWSELPPGAGLGSSAAYSVCLAAALLT CEE+ NPLKDG V+RW +E
Sbjct: 104 RKQRTLPSLDMVVWSELPPGAGLGSSAAYSVCLAAALLTACEEVSNPLKDGVSVSRWPEE 163
Query: 181 DLELINKWAFQGERMIHGNPSGVDNAVSTWGGAL 214
DL+ INKWAF+GER+IHGNPSGVDNA+STW L
Sbjct: 164 DLKSINKWAFEGERVIHGNPSGVDNAISTWASRL 197
>gb|EDM13938.1| mevalonate kinase, isoform CRA_b [Rattus norvegicus]
Length = 255
Score = 257 bits (657), Expect = 1e-66, Method: Composition-based stats.
Identities = 135/181 (74%), Positives = 154/181 (85%)
Query: 34 NLRTFLRLQPHSNGKVDLSLPNIGIKRAWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKE 93
NLRTFL L+P SNGKV L+LPN+GIK+ WDVA LQ LDT FLEQGDV PT EQ+EKLK+
Sbjct: 51 NLRTFLVLRPQSNGKVSLNLPNVGIKQVWDVATLQLLDTGFLEQGDVPAPTLEQLEKLKK 110
Query: 94 VAGLPDDCAVTERLAVLAFLYLYLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCL 153
VAGLP DC E L++LAFLYLYL+ICRKQR LPSLDI+VWSELPPGAGLGSSAAYSVC+
Sbjct: 111 VAGLPRDCVGNEGLSLLAFLYLYLAICRKQRTLPSLDIMVWSELPPGAGLGSSAAYSVCV 170
Query: 154 AAALLTVCEEIPNPLKDGDCVNRWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGA 213
AAALLT CEE+ NPLKD + W +EDL+ INKWA++GER+IHGNPSGVDN+VSTWG
Sbjct: 171 AAALLTACEEVTNPLKDRGSIGSWPEEDLKSINKWAYEGERVIHGNPSGVDNSVSTWGSQ 230
Query: 214 L 214
L
Sbjct: 231 L 231
>gb|EDM13939.1| mevalonate kinase, isoform CRA_c [Rattus norvegicus]
Length = 219
Score = 256 bits (654), Expect = 2e-66, Method: Composition-based stats.
Identities = 135/181 (74%), Positives = 154/181 (85%)
Query: 34 NLRTFLRLQPHSNGKVDLSLPNIGIKRAWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKE 93
NLRTFL L+P SNGKV L+LPN+GIK+ WDVA LQ LDT FLEQGDV PT EQ+EKLK+
Sbjct: 15 NLRTFLVLRPQSNGKVSLNLPNVGIKQVWDVATLQLLDTGFLEQGDVPAPTLEQLEKLKK 74
Query: 94 VAGLPDDCAVTERLAVLAFLYLYLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCL 153
VAGLP DC E L++LAFLYLYL+ICRKQR LPSLDI+VWSELPPGAGLGSSAAYSVC+
Sbjct: 75 VAGLPRDCVGNEGLSLLAFLYLYLAICRKQRTLPSLDIMVWSELPPGAGLGSSAAYSVCV 134
Query: 154 AAALLTVCEEIPNPLKDGDCVNRWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGA 213
AAALLT CEE+ NPLKD + W +EDL+ INKWA++GER+IHGNPSGVDN+VSTWG
Sbjct: 135 AAALLTACEEVTNPLKDRGSIGSWPEEDLKSINKWAYEGERVIHGNPSGVDNSVSTWGSQ 194
Query: 214 L 214
L
Sbjct: 195 L 195
>ref|XP_001779131.1| predicted protein [Physcomitrella patens subsp. patens]
gb|EDQ56077.1| predicted protein [Physcomitrella patens subsp. patens]
Length = 406
Score = 251 bits (641), Expect = 7e-65, Method: Composition-based stats.
Identities = 167/395 (42%), Positives = 217/395 (54%), Gaps = 34/395 (8%)
Query: 10 APGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKRAWDVARLQS 69
APGKVIL GEHAVVHG A+A +L L T ++P + L LP +G+ W + ++
Sbjct: 15 APGKVILSGEHAVVHGTSAVAAALGLYTTATIRPGMDDSCVLDLPQLGVYSKWPLKMIEE 74
Query: 70 LDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTER--------------LAVLAFLYL 115
L T Q + P V E + P A ER AV AFL+L
Sbjct: 75 LIT----QPHLLNPKPAHVTSYSE-SEWPQLAAFVERQVRSLSAKGAKGADAAVTAFLFL 129
Query: 116 YLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEI--PNPLKDGDC 173
Y SI Q A + V SELP GAGLGSSAAY V L ALL EI P G+
Sbjct: 130 YTSILGLQPA----TVRVSSELPVGAGLGSSAAYCVALTTALLAYSREIELPQLPSVGEE 185
Query: 174 VNR----WTKED---LELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKR 226
V+ W D ++L+NKWAF+GER+IHG PSG+DN VST+G +++ +G+I+ L
Sbjct: 186 VSTDRKIWFDVDEKKVDLVNKWAFEGERIIHGRPSGIDNTVSTYGYVVKFKKGQITRLHT 245
Query: 227 SPALQILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAP 286
L++LLTNT+V RNT+ALVAGV R L+ P + + +ID I+ E +L E
Sbjct: 246 QMPLRMLLTNTQVGRNTKALVAGVGERALRHPAAMGAIFKAIDEIAEEVVTILQTPPETA 305
Query: 287 --APEQYLVLEELIDMNQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLL 344
Q + L+EL+DMNQ L +GV H S++ +CQ+T A L SKLTGAGGGGC +TLL
Sbjct: 306 RLGKIQEIRLQELVDMNQGLLQGIGVSHLSIESICQITAAYRLSSKLTGAGGGGCVLTLL 365
Query: 345 KPGLEQPEVEATKQALTSCGFDCLETSIGAPGVSI 379
L VE K + GF C E IG GV +
Sbjct: 366 PHKLSSTSVELVKVDIEGKGFSCFEAVIGGNGVQV 400
>ref|XP_567851.1| cystathionine beta-lyase [Cryptococcus neoformans var. neoformans
JEC21]
ref|XP_772806.1| hypothetical protein CNBK1800 [Cryptococcus neoformans var.
neoformans B-3501A]
gb|EAL18159.1| hypothetical protein CNBK1800 [Cryptococcus neoformans var.
neoformans B-3501A]
gb|AAW46334.1| cystathionine beta-lyase, putative [Cryptococcus neoformans var.
neoformans JEC21]
Length = 900
Score = 246 bits (629), Expect = 2e-63, Method: Composition-based stats.
Identities = 161/405 (39%), Positives = 219/405 (54%), Gaps = 47/405 (11%)
Query: 2 LSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKRA 61
+ E + VSAPGKVIL GEHAVVHG A+A S++LR F L P +GKV L +PNIG++
Sbjct: 478 IEEDIAVSAPGKVILFGEHAVVHGVTAIASSVDLRCFSVLSPRRDGKVGLEVPNIGVELE 537
Query: 62 WDVARL-----------------QSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVT 104
W++++L + LDT+ L+ + T +V K T
Sbjct: 538 WEISKLPWNLLPVHANGGRHVADKELDTALLQAVEGAVNTHVEVGK-------------T 584
Query: 105 ERLAVLAFLYLYLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEI 164
A +AFLYLY+ I ++ S+ S LP AGLGSSAAYS C+AA+ L + +
Sbjct: 585 GIGACVAFLYLYMMISGEETNALSVTFTASSNLPISAGLGSSAAYSTCVAASFLLARQHL 644
Query: 165 PNPLKDGDCVNRWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRY------HQ 218
P D R KED +L++ WAF E+++HGNPSG+DNAV+ GGA+ + Q
Sbjct: 645 TIPSAD-----RLPKEDTDLVDGWAFLAEKVLHGNPSGIDNAVAVRGGAVAFTRSVGGKQ 699
Query: 219 GKISSLKRSPALQILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERV 278
G + L ++++LLTNT VPR+T+ LVAGV + L P+ V +L SI IS E +
Sbjct: 700 GGMDGLFEFSSVRLLLTNTLVPRDTKTLVAGVSAKRLAEPQAVNSILDSIQTISDEARSL 759
Query: 279 LGEMGEAPAPEQYLV--LEELIDMNQHHLNALGVGHASLDQLCQVTRAR--GLHSKLTGA 334
LG G P LV LE LI N HL LGV H SL+ + T L +KLTGA
Sbjct: 760 LG--GGKPVERSILVKRLEALIKENHEHLVELGVSHPSLEMIVAATAQAPFELATKLTGA 817
Query: 335 GGGGCGITLLKPGLEQPEVEATKQALTSCGFDCLETSIGAPGVSI 379
GGGGC +TL+ + + Q L GF T++G PG +
Sbjct: 818 GGGGCALTLIPDDFPESSLNELIQTLEGHGFQAHLTTLGGPGFGV 862
>ref|XP_567850.1| cystathionine beta-lyase [Cryptococcus neoformans var. neoformans
JEC21]
ref|XP_772807.1| hypothetical protein CNBK1800 [Cryptococcus neoformans var.
neoformans B-3501A]
gb|EAL18160.1| hypothetical protein CNBK1800 [Cryptococcus neoformans var.
neoformans B-3501A]
gb|AAW46333.1| cystathionine beta-lyase, putative [Cryptococcus neoformans var.
neoformans JEC21]
Length = 918
Score = 246 bits (628), Expect = 2e-63, Method: Composition-based stats.
Identities = 161/405 (39%), Positives = 219/405 (54%), Gaps = 47/405 (11%)
Query: 2 LSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKRA 61
+ E + VSAPGKVIL GEHAVVHG A+A S++LR F L P +GKV L +PNIG++
Sbjct: 478 IEEDIAVSAPGKVILFGEHAVVHGVTAIASSVDLRCFSVLSPRRDGKVGLEVPNIGVELE 537
Query: 62 WDVARL-----------------QSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVT 104
W++++L + LDT+ L+ + T +V K T
Sbjct: 538 WEISKLPWNLLPVHANGGRHVADKELDTALLQAVEGAVNTHVEVGK-------------T 584
Query: 105 ERLAVLAFLYLYLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEI 164
A +AFLYLY+ I ++ S+ S LP AGLGSSAAYS C+AA+ L + +
Sbjct: 585 GIGACVAFLYLYMMISGEETNALSVTFTASSNLPISAGLGSSAAYSTCVAASFLLARQHL 644
Query: 165 PNPLKDGDCVNRWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRY------HQ 218
P D R KED +L++ WAF E+++HGNPSG+DNAV+ GGA+ + Q
Sbjct: 645 TIPSAD-----RLPKEDTDLVDGWAFLAEKVLHGNPSGIDNAVAVRGGAVAFTRSVGGKQ 699
Query: 219 GKISSLKRSPALQILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERV 278
G + L ++++LLTNT VPR+T+ LVAGV + L P+ V +L SI IS E +
Sbjct: 700 GGMDGLFEFSSVRLLLTNTLVPRDTKTLVAGVSAKRLAEPQAVNSILDSIQTISDEARSL 759
Query: 279 LGEMGEAPAPEQYLV--LEELIDMNQHHLNALGVGHASLDQLCQVTRAR--GLHSKLTGA 334
LG G P LV LE LI N HL LGV H SL+ + T L +KLTGA
Sbjct: 760 LG--GGKPVERSILVKRLEALIKENHEHLVELGVSHPSLEMIVAATAQAPFELATKLTGA 817
Query: 335 GGGGCGITLLKPGLEQPEVEATKQALTSCGFDCLETSIGAPGVSI 379
GGGGC +TL+ + + Q L GF T++G PG +
Sbjct: 818 GGGGCALTLIPDDFPESSLNELIQTLEGHGFQAHLTTLGGPGFGV 862
>gb|AAD45421.1|L77688_1 mevalonate kinase [Arabidopsis thaliana]
Length = 376
Score = 238 bits (608), Expect = 5e-61, Method: Composition-based stats.
Identities = 150/384 (39%), Positives = 228/384 (59%), Gaps = 30/384 (7%)
Query: 10 APGKVILHGEHAVVHGKVALAVSLNLRTFLRLQ---PHSNGKVDLSLPNIGIKRAWDVAR 66
APGK+IL GEHAVVHG A+A +++L T++ L+ P +N ++ L L +I ++ +W +AR
Sbjct: 7 APGKIILAGEHAVVHGSTAVAAAIDLYTYVTLRFPLPSNNDRLTLQLKDISLEFSWSLAR 66
Query: 67 LQS---LDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLA-----FLYLYLS 118
++ D+S L + +TP S E LK +A L ++ + + L+ FL+LY
Sbjct: 67 IKEAIPYDSSTLCR---STPASCSEETLKSIAVLVEEQNLPKEKMWLSSGISTFLWLYTR 123
Query: 119 ICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWT 178
I A +V+ SELP G+GLGSSAA V L AALL + + + N W+
Sbjct: 124 IIGFNPA----TVVINSELPYGSGLGSSAALCVALTAALLA------SSISEKTRGNGWS 173
Query: 179 KED---LELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLT 235
D LEL+NKWAF+GE++IHG PSG+DN VS +G +++ G+I+ L+ + L++L+T
Sbjct: 174 SLDETNLELLNKWAFEGEKIIHGKPSGIDNTVSAYGNMIKFCSGEITRLQSNMPLRMLIT 233
Query: 236 NTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLE 295
NT+V RNT+ALV+GV R ++ P+ + + ++D+IS E ++ E E+ ++
Sbjct: 234 NTRVGRNTKALVSGVSQRAVRHPDAMKSVFNAVDSISKELAAIIQSKDETSVTEKEERIK 293
Query: 296 ELIDMNQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEA 355
EL++MNQ L ++GV H+S++ + T L SKLTGAGGGGC +TLL G V+
Sbjct: 294 ELMEMNQGLLLSMGVSHSSIEAVILTTVKHKLVSKLTGAGGGGCVLTLLPTG---TVVDK 350
Query: 356 TKQALTSCGFDCLETSIGAPGVSI 379
+ L S GF C IG G I
Sbjct: 351 VVEELESSGFQCFTALIGGNGAQI 374
>gb|AAL18925.1|AF429384_1 mevalonate kinase [Hevea brasiliensis]
dbj|BAF98283.1| mevalonate kinase [Hevea brasiliensis]
Length = 386
Score = 236 bits (603), Expect = 2e-60, Method: Composition-based stats.
Identities = 153/385 (39%), Positives = 228/385 (59%), Gaps = 30/385 (7%)
Query: 10 APGKVILHGEHAVVHGKVALAVSLNLRTFLRLQ---PHSNGKVDLSLPNIGIKRAWDVAR 66
APGK+IL GEHAVVHG A+A S+NL T++ L ++ + L L ++ ++ +W + R
Sbjct: 7 APGKIILSGEHAVVHGSTAVAASINLYTYVTLSFATAENDDSLKLQLKDLALEFSWPIGR 66
Query: 67 LQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVL-----AFLYLYLSICR 121
++ S L +T TS +E +K ++ L ++ + E L AFL+LY SI
Sbjct: 67 IREA-LSNLGAPSSSTRTSCSMESIKTISALVEEENIPEAKIALTSGVSAFLWLYTSI-- 123
Query: 122 KQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWT--- 178
+ +VV S+LP G+GLGSSAA+ V L+AALL + + K W+
Sbjct: 124 --QGFKPATVVVTSDLPLGSGLGSSAAFCVALSAALLAFSDSVNVDTKHLG----WSIFG 177
Query: 179 KEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTK 238
+ DLEL+NKWA +GE++IHG PSG+DN VS +G +++ G ++ +K + L++L+TNT+
Sbjct: 178 ESDLELLNKWALEGEKIIHGKPSGIDNTVSAYGNMIKFKSGNLTRIKSNMPLKMLVTNTR 237
Query: 239 VPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLV----- 293
V RNT+ALVAGV R L+ P ++ + ++D+IS E ++ ++PAP+ +
Sbjct: 238 VGRNTKALVAGVSERTLRHPNAMSFVFNAVDSISNELANII----QSPAPDDVSITEKEE 293
Query: 294 -LEELIDMNQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPE 352
LEEL++MNQ L +GV HAS++ + + T L SKLTGAGGGGC +TLL L
Sbjct: 294 KLEELMEMNQGLLQCMGVSHASIETVLRTTLKYKLASKLTGAGGGGCVLTLLPTLLSGTV 353
Query: 353 VEATKQALTSCGFDCLETSIGAPGV 377
V+ L SCGF CL IG GV
Sbjct: 354 VDKAIAELESCGFQCLIAGIGGNGV 378
>gb|ABK95983.1| unknown [Populus trichocarpa]
Length = 387
Score = 235 bits (600), Expect = 4e-60, Method: Composition-based stats.
Identities = 162/392 (41%), Positives = 234/392 (59%), Gaps = 28/392 (7%)
Query: 10 APGKVILHGEHAVVHGKVALAVSLNLRTFLRLQ-PHSN---GKVDLSLPNIGIKRAWDVA 65
APGK+IL GEHAVVHG A+A S+ L T++ LQ P SN ++ L L ++ ++ +W +
Sbjct: 7 APGKIILSGEHAVVHGSTAVAASIGLCTYVSLQVPPSNENDDRLTLQLKDMALEFSWPIG 66
Query: 66 RLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERL-----AVLAFLYLYLSIC 120
R++ +S L +TPTS E K + L ++ + E V AFL+LY SI
Sbjct: 67 RIKEALSS-LGGPFPSTPTSCSAESFKLILALIEEQNILEEKISLASGVSAFLWLYTSIL 125
Query: 121 RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLK-DGDCVNRWTK 179
+ +VV S+LP G+GLGSSAA V +AALL + + +K +G V + +
Sbjct: 126 ----GIKPATVVVTSDLPLGSGLGSSAALCVAFSAALLACSDTVNIDMKQEGWLV--FGE 179
Query: 180 EDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKV 239
+LEL+NKWAF+GE++IHG PSG+DN VST+G +++ G ++ +K S L++L+TNTKV
Sbjct: 180 SELELLNKWAFEGEKIIHGKPSGIDNTVSTYGNMIKFRSGNLTRIKSSMPLKMLITNTKV 239
Query: 240 PRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLV------ 293
RNT+ALVAGV R L+ P+ ++ + ++D+IS E V+ + PA + +
Sbjct: 240 GRNTKALVAGVSERTLRNPDAMSSVFNAVDSISKELANVI----QTPASDDLSITAKEEK 295
Query: 294 LEELIDMNQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEV 353
LEEL++MN L +GV HAS++ + + T L SKLTGAGGGGC +TLL L V
Sbjct: 296 LEELMEMNHGLLQCMGVSHASIETVLRTTLKYKLASKLTGAGGGGCVLTLLPTLLSGTIV 355
Query: 354 EATKQALTSCGFDCLETSIGAPGVSI-HSATS 384
+ L SCGF CL IG G I SA+S
Sbjct: 356 DKVIAELESCGFQCLIAGIGGNGAEICFSASS 387
>ref|NP_198097.1| MK/MVK; mevalonate kinase [Arabidopsis thaliana]
ref|NP_851084.1| MK/MVK; mevalonate kinase [Arabidopsis thaliana]
sp|P46086|KIME_ARATH Mevalonate kinase (MK)
gb|AAD31719.1|AF141853_1 mevalonate kinase [Arabidopsis thaliana]
emb|CAA54820.1| mevalonate kinase [Arabidopsis thaliana]
gb|AAM13164.1| mevalonate kinase [Arabidopsis thaliana]
gb|AAM60916.1| mevalonate kinase [Arabidopsis thaliana]
gb|AAN72115.1| mevalonate kinase [Arabidopsis thaliana]
Length = 378
Score = 234 bits (597), Expect = 8e-60, Method: Composition-based stats.
Identities = 149/386 (38%), Positives = 227/386 (58%), Gaps = 32/386 (8%)
Query: 10 APGKVILHGEHAVVHGKVALAVSLNLRTFLRLQ-----PHSNGKVDLSLPNIGIKRAWDV 64
APGK+IL GEHAVVHG A+A +++L T++ L+ +N ++ L L +I ++ +W +
Sbjct: 7 APGKIILAGEHAVVHGSTAVAAAIDLYTYVTLRFPLPSAENNDRLTLQLKDISLEFSWSL 66
Query: 65 ARLQS---LDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLA-----FLYLY 116
AR++ D+S L + +TP S E LK +A L ++ + + L+ FL+LY
Sbjct: 67 ARIKEAIPYDSSTLCR---STPASCSEETLKSIAVLVEEQNLPKEKMWLSSGISTFLWLY 123
Query: 117 LSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNR 176
I A +V+ SELP G+GLGSSAA V L AALL + + + N
Sbjct: 124 TRIIGFNPA----TVVINSELPYGSGLGSSAALCVALTAALLA------SSISEKTRGNG 173
Query: 177 WTKED---LELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQIL 233
W+ D LEL+NKWAF+GE++IHG PSG+DN VS +G +++ G+I+ L+ + L++L
Sbjct: 174 WSSLDETNLELLNKWAFEGEKIIHGKPSGIDNTVSAYGNMIKFCSGEITRLQSNMPLRML 233
Query: 234 LTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLV 293
+TNT+V RNT+ALV+GV R ++ P+ + + ++D+IS E ++ E E+
Sbjct: 234 ITNTRVGRNTKALVSGVSQRAVRHPDAMKSVFNAVDSISKELAAIIQSKDETSVTEKEER 293
Query: 294 LEELIDMNQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEV 353
++EL++MNQ L ++GV H+S++ + T L SKLTGAGGGGC +TLL G V
Sbjct: 294 IKELMEMNQGLLLSMGVSHSSIEAVILTTVKHKLVSKLTGAGGGGCVLTLLPTG---TVV 350
Query: 354 EATKQALTSCGFDCLETSIGAPGVSI 379
+ + L S GF C IG G I
Sbjct: 351 DKVVEELESSGFQCFTALIGGNGAQI 376
>ref|XP_645383.1| hypothetical protein DDBDRAFT_0168621 [Dictyostelium discoideum
AX4]
sp|Q86AG7|KIME_DICDI Mevalonate kinase (MK)
gb|AAO51522.1| similar to Rattus norvegicus (Rat). Mevalonate kinase (EC 2.7.1.36)
(MK) [Dictyostelium discoideum]
gb|EAL71443.1| hypothetical protein DDBDRAFT_0168621 [Dictyostelium discoideum
AX4]
Length = 390
Score = 233 bits (593), Expect = 2e-59, Method: Composition-based stats.
Identities = 144/394 (36%), Positives = 222/394 (56%), Gaps = 35/394 (8%)
Query: 5 VLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNI---GIKRA 61
++ VSAPGK+IL GEHAVV K A+A +L+LRT + P++N + L P++ G+ R
Sbjct: 8 IIQVSAPGKIILFGEHAVVLEKTAIASALSLRTTVTFTPNTNNTLLLDFPDLAGFGV-RE 66
Query: 62 WDVARLQSLDTSFLEQGDVTTPT------SEQVEKLKEVAGLPDDCAVTERLAVLAFLYL 115
W + + LD F D+ P +++ K+ ++ G + FL+L
Sbjct: 67 WSLDEFKKLD-HFPNDIDILKPIECSELFQQELNKIIDIKG------------IHTFLFL 113
Query: 116 YLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLT-----VCEEIPNPLKD 170
+ ++ + +A +I + S+LP GAGLGSSA++ V + A LL +C +
Sbjct: 114 FCALTKCTKAY---NIKITSDLPIGAGLGSSASFCVSICAGLLKAFDTYICGGCKQCIGG 170
Query: 171 GDCVNRWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRS--P 228
+ E L LIN W+ QGE+++HG PSG+DNAV+T+G AL + + + + P
Sbjct: 171 QGQQQQICNEQLNLINLWSLQGEKIMHGTPSGIDNAVATFGKALTFTRKNGYKILENGIP 230
Query: 229 ALQILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAP 288
L+IL+TNT+V R+T+ LV GV R +P ++ P+ ID IS +C +
Sbjct: 231 PLRILITNTRVSRSTKTLVEGVIQRSKLYPTLIDPVSNLIDTISSQCIESFNQYHTDKDY 290
Query: 289 EQYL-VLEELIDMNQHHLNA-LGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKP 346
E+ ++ + DMNQH L+ GVGH+S+D + +T++ G H+KLTGAGGGGC ITLLK
Sbjct: 291 EKLQQTMDLMFDMNQHLLSGCYGVGHSSIDTIVSITKSLGFHTKLTGAGGGGCVITLLKQ 350
Query: 347 GLEQPEVEATKQALTSCGFDCLETSIGAPGVSIH 380
++ K L+S GF+ E +IG PGVSI+
Sbjct: 351 DTTIDQLSNLKLTLSSNGFESWEATIGDPGVSIN 384
>emb|CAO17636.1| unnamed protein product [Vitis vinifera]
Length = 388
Score = 233 bits (593), Expect = 3e-59, Method: Composition-based stats.
Identities = 156/392 (39%), Positives = 226/392 (57%), Gaps = 39/392 (9%)
Query: 10 APGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHS----NGKVDLSLPNIGIKRAWDVA 65
APGK+IL GEHAVVHG A+A S+NL T + L+ HS + + L L ++ ++ +W +
Sbjct: 7 APGKIILAGEHAVVHGSAAVAASINLYTHVSLRFHSISDDDHTLKLHLKDMALEFSWSIE 66
Query: 66 R----LQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERL-----AVLAFLYLY 116
R LQ + F +TPT+ E +K +A L + + E V AFL+LY
Sbjct: 67 RIKEVLQEVGCPF-----SSTPTTCTPEFIKLIAALLIEQNIPEAKLGLASGVSAFLWLY 121
Query: 117 LSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNR 176
I + +V+ SELP G+GLGSSA++ V L+AALL + +
Sbjct: 122 TCI----QGFKPATVVITSELPLGSGLGSSASFCVSLSAALLALSDSASLDFSHPG---- 173
Query: 177 WT---KEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQIL 233
W+ + +LEL+NKWAF+GE++IHG PSG+DN+VST+G +++ G ++ L + L++L
Sbjct: 174 WSVFGENELELVNKWAFEGEKIIHGKPSGIDNSVSTFGNMIKFKSGSLTRLSSNMPLKML 233
Query: 234 LTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLV 293
+TNTKV RNT+ALVAGV R L+ P + + ++D IS E ++ ++PAP++ +
Sbjct: 234 VTNTKVGRNTKALVAGVSERTLRHPNAMKAVFNAVDFISEELSTII----QSPAPDELSI 289
Query: 294 LE------ELIDMNQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPG 347
E EL++MNQ L +GV HAS++ + + T L SKLTGAGGGGC +TLL
Sbjct: 290 TEKEEKLGELMEMNQGLLQCMGVSHASIETVLRTTLKYKLASKLTGAGGGGCVLTLLPTL 349
Query: 348 LEQPEVEATKQALTSCGFDCLETSIGAPGVSI 379
L V AL SC F CL IG GV I
Sbjct: 350 LSGTVVNKVIAALESCEFQCLIAGIGGNGVEI 381
>ref|XP_001527900.1| hypothetical protein LELG_00420 [Lodderomyces elongisporus NRRL
YB-4239]
gb|EDK42242.1| hypothetical protein LELG_00420 [Lodderomyces elongisporus NRRL
YB-4239]
Length = 439
Score = 232 bits (591), Expect = 5e-59, Method: Composition-based stats.
Identities = 151/394 (38%), Positives = 224/394 (56%), Gaps = 28/394 (7%)
Query: 6 LLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHS--NGKVDLSLPNIGIKRAWD 63
+VSAPGKVI+ GEHA V+GK A+A +L+LR FL + P + + V L P+IG+ +WD
Sbjct: 11 FVVSAPGKVIIFGEHAAVYGKPAIAAALSLRCFLLVTPSTGDSNMVRLKFPDIGLDHSWD 70
Query: 64 VARLQ----SLDTSFLEQGDVTTPTS---EQVEKLKEVAGLPDDCAVTERLAVLAFLYLY 116
++ + G P E V+ L + DD +A FLYLY
Sbjct: 71 ISSIPWETIKAKVKADSNGKPQPPAELDPEIVDSLSPLLRNLDDN--VHYIACFCFLYLY 128
Query: 117 LSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNP-LKDGDCVN 175
++C + L VV S LP GAGLGSSA+ +VCL+AAL + I +P L + D V
Sbjct: 129 TNLCSQD--LQGYTFVVRSTLPIGAGLGSSASTAVCLSAALSKLGNWIKDPKLSNHDHVL 186
Query: 176 RWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQ---GKISSLKRS----P 228
+L+ I+ W+ GE+ HGNPSG+DNAV+T GGA++Y + SSL+ S P
Sbjct: 187 ESEIPELDFIDNWSLIGEKCFHGNPSGIDNAVATHGGAVKYQRILNSTKSSLRSSIRDFP 246
Query: 229 ALQILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERV--LGEMGEAP 286
+++LLTNTKVP++T LVAGV +FP+I P+L +++ IS + V L + G+
Sbjct: 247 PIKLLLTNTKVPKSTAKLVAGVGELTKEFPDITNPILNAVEFISEQAYEVMHLPQFGK-- 304
Query: 287 APEQYLVLEELIDMNQHHLNALGVGHASLDQLCQVTRARGL-HSKLTGAGGGGCGITLLK 345
++ L +L++MN L ALGV H +L+ + ++ L +KLTGAGGGGC ITL+
Sbjct: 305 --QETATLRKLVNMNHGLLVALGVSHPALETVKIISDKYNLGATKLTGAGGGGCAITLVD 362
Query: 346 PGLEQPEVEATKQALTSCGFDCLETSIGAPGVSI 379
+++ + + + GF+ ETS+G GV +
Sbjct: 363 ESIDKSVIHNAMKEYENEGFESFETSLGGKGVGM 396
>ref|XP_723495.1| mevalonate kinase [Candida albicans SC5314]
ref|XP_723305.1| mevalonate kinase [Candida albicans SC5314]
gb|EAL04601.1| hypothetical protein CaO19.12272 [Candida albicans SC5314]
gb|EAL04797.1| hypothetical protein CaO19.4809 [Candida albicans SC5314]
Length = 431
Score = 229 bits (585), Expect = 2e-58, Method: Composition-based stats.
Identities = 146/398 (36%), Positives = 224/398 (56%), Gaps = 23/398 (5%)
Query: 6 LLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGK-VDLSLPNIGIKRAWDV 64
+V APGKVI+ GEHA V+GK A+A +L+LR +L + P S+ + L P+I + +W++
Sbjct: 6 FIVGAPGKVIIFGEHAAVYGKPAIAAALSLRCYLLVSPSSDSNTIRLQFPDIKLDHSWNI 65
Query: 65 ARLQSLDTS-FLEQGDVTTP------TSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYL 117
L + +L P E V+KL D+ A FLYL +
Sbjct: 66 KDLPWEEIKPYLTYDSANKPQIPSELVPEIVDKLSSFLNGFDN--KMHYYACFCFLYLLM 123
Query: 118 SICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNP-LKDGDCVNR 176
++C + + ++ +V S LP GAGLGSSA+ SVCL++AL + I P L + D ++
Sbjct: 124 NLCDSK--VSGMNFIVRSTLPIGAGLGSSASTSVCLSSALALMGGWINKPSLHENDKLDT 181
Query: 177 WTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKI-------SSLKRSPA 229
DLE I+KW+ GE+ HGNPSG+DNAV+T+GGA+ + + ++++ PA
Sbjct: 182 ADIPDLEFIDKWSLIGEKCFHGNPSGIDNAVATFGGAVMFQRTSTPEQPSIRTNMRNFPA 241
Query: 230 LQILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPE 289
+++LLTNTKVP++T LVAGV +F I +LT+I+ +S E +V+ M E
Sbjct: 242 IKLLLTNTKVPKSTADLVAGVGRLNAEFNSISTSILTAIEHLSQEAYKVM--MNPMFGKE 299
Query: 290 QYLVLEELIDMNQHHLNALGVGHASLDQLCQV-TRARGLHSKLTGAGGGGCGITLLKPGL 348
+ VL +L+++N L ALGV H +L+ + + + R +KLTGAGGGGC ITL+ +
Sbjct: 300 ETNVLRKLVNINHGLLVALGVSHPALETVKIIGDKHRIGATKLTGAGGGGCAITLVNDDV 359
Query: 349 EQPEVEATKQALTSCGFDCLETSIGAPGVSIHSATSLD 386
E+ + + G++ ETS+G GV I LD
Sbjct: 360 EESVIHNAIKEFEDSGYESFETSLGGKGVGILFHEDLD 397
>gb|ABD32397.1| Mevalonate and galactokinase [Medicago truncatula]
Length = 388
Score = 225 bits (574), Expect = 4e-57, Method: Composition-based stats.
Identities = 155/389 (39%), Positives = 239/389 (61%), Gaps = 32/389 (8%)
Query: 10 APGKVILHGEHAVVHGKVALAVSLNLRTFLRLQ---PHSNGK--VDLSLPNIGIKRAWDV 64
APGK+IL GEHAVVHG A+A S++L T++ L+ P S + + L L + ++ W +
Sbjct: 7 APGKIILAGEHAVVHGSTAVASSIDLYTYVSLRFSTPSSENEESLRLLLKDTALEFEWPI 66
Query: 65 ARLQSLDTSFLEQGDV--TTPTSEQVEKLKEVAGLPDDCAVTERL-----AVLAFLYLYL 117
+R++ +F E + +TP S VE K +A L ++ + E V AFL+LY
Sbjct: 67 SRIRE---AFPESVSLLSSTPNSCSVECAKSIASLVEELNIPEAKIGLASGVAAFLWLYS 123
Query: 118 SICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIP-NPLKDGDCVNR 176
SI + +V+ S+LP G+GLGSSAA+ V LAAA L V + + + ++ G +
Sbjct: 124 SI----QGFKPATVVINSDLPLGSGLGSSAAFCVALAAAFLAVTDSVSVDVIRQG--WHS 177
Query: 177 WTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTN 236
+ +++L+L+NKWAF+GE++IHG PSG+DN VS++G + + G ++ +K + +L++L+TN
Sbjct: 178 FGEKELDLVNKWAFEGEKIIHGKPSGIDNTVSSYGNIISFKSGNLTRMKSNASLKMLITN 237
Query: 237 TKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLV--- 293
T+V RNT+ALVAGV R+L+ P+ +A + T++D+IS E VL ++P P++ V
Sbjct: 238 TRVGRNTKALVAGVSERMLRHPDAMAFVFTAVDSISKELTTVL----QSPTPDELSVTTL 293
Query: 294 ---LEELIDMNQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQ 350
+EEL++MNQ L ++GV HA+++ + + T L SKLTGAGGGGC +TLL L
Sbjct: 294 EEKVEELMEMNQGLLQSMGVSHATIETVLRTTLKYKLSSKLTGAGGGGCVLTLLPTLLSP 353
Query: 351 PEVEATKQALTSCGFDCLETSIGAPGVSI 379
V+ L S GF C IG GV I
Sbjct: 354 TVVDKVIAELESNGFQCFTAGIGGNGVEI 382
>ref|XP_460851.1| hypothetical protein DEHA0F12188g [Debaryomyces hansenii CBS767]
emb|CAG89196.1| unnamed protein product [Debaryomyces hansenii CBS767]
Length = 433
Score = 222 bits (566), Expect = 4e-56, Method: Composition-based stats.
Identities = 139/397 (35%), Positives = 223/397 (56%), Gaps = 22/397 (5%)
Query: 6 LLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSN-GKVDLSLPNIGIKRAWDV 64
LVSAPGKVI++GEH+ V+GK A+A +L+LR +L + P + + L P+IG+ +W+
Sbjct: 6 FLVSAPGKVIIYGEHSAVYGKPAIAAALSLRAYLLVTPCEDVNDIRLDFPDIGLSHSWNK 65
Query: 65 ARLQSLD----TSFLEQGDVTTP--TSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLS 118
+ D +F ++ V T E V+ L V L D + A L FLYLY +
Sbjct: 66 ENIPWEDIRKFVTFKDEKPVVTEELVPEIVDLLSTV--LADVESKLHYTACLCFLYLYAN 123
Query: 119 ICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDG-DCVNRW 177
+ K +P + +V S LP GAGLGSSA +VCLA+AL + + + + V +
Sbjct: 124 LSNKD--VPGMRFIVKSTLPIGAGLGSSACTAVCLASALARLGKHVSAACHTSTEKVYKK 181
Query: 178 TKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISS-------LKRSPAL 230
DL+ I+ W+ GE+ HGNPSG+DNAV+T+GGA+ + + I S ++ P +
Sbjct: 182 ENSDLDFIDSWSLMGEKCFHGNPSGIDNAVATYGGAVMFQRTTIPSKPSVRTTMRNFPPI 241
Query: 231 QILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQ 290
+++L NTKVPR+T ALV V +P+ +L +++ + E +++ + + E+
Sbjct: 242 KLILINTKVPRSTAALVGNVAQVNRTYPKCAGSILDAMEHLVFEAYQIM--IRPSFGKEE 299
Query: 291 YLVLEELIDMNQHHLNALGVGHASLDQLCQVTRARGLHS-KLTGAGGGGCGITLLKPGLE 349
L EL+++N L ALGV H +L+++ + G+ S KLTGAGGGGC I+L+ +E
Sbjct: 300 KDQLRELVNINHGLLVALGVSHPALEKIKIIGDTHGIGSTKLTGAGGGGCAISLVHDDVE 359
Query: 350 QPEVEATKQALTSCGFDCLETSIGAPGVSIHSATSLD 386
+ ++ + + G++ ETS+G GV S +D
Sbjct: 360 EEVIQKAIKEFENEGYETFETSLGGKGVGSLSLEDVD 396
>ref|XP_001382664.2| mevalonate kinase [Pichia stipitis CBS 6054]
gb|ABN64635.2| mevalonate kinase [Pichia stipitis CBS 6054]
Length = 432
Score = 220 bits (560), Expect = 2e-55, Method: Composition-based stats.
Identities = 140/394 (35%), Positives = 223/394 (56%), Gaps = 26/394 (6%)
Query: 2 LSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSN-GKVDLSLPNIGIKR 60
+S VSAPGKVI+ GEH+ V+GK A+A +L+LR +L + P + ++LS P+I +
Sbjct: 1 MSTPFFVSAPGKVIIFGEHSAVYGKPAIAAALSLRAYLLVTPSQDPDTINLSFPDINLTH 60
Query: 61 AWD--------VARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAF 112
+W+ + + +L + + + P E V++L V L D + A L F
Sbjct: 61 SWNKNDIPWDSIVKHINLVDNLPQTSEELVP--EIVDQLGSV--LADLNSSLHYTACLCF 116
Query: 113 LYLYLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNP-LKDG 171
LYLY +C ++ L + + S LP GAGLGSSA+ +VCLA+AL + + +
Sbjct: 117 LYLYTHLCNQE--LAGMSFCIRSTLPIGAGLGSSASTAVCLASALAILGNRVTSASFLQT 174
Query: 172 DCVNRWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQ-------GKISSL 224
D + + DL+ I+ W+ GE+ HGNPSG+DNAV+T GGA+ + + +S+
Sbjct: 175 DKILKKENNDLDFIDSWSLMGEKCFHGNPSGIDNAVATHGGAVMFQRMNNPAQPSVRTSM 234
Query: 225 KRSPALQILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGE 284
+ PA+++LLTNTKVPR+T LV GV +++P+ +L +++ +S +++ +
Sbjct: 235 RNFPAIKLLLTNTKVPRSTADLVGGVGKLNVEYPKTSNSILEAMEHLSNTAYQIM--VRP 292
Query: 285 APAPEQYLVLEELIDMNQHHLNALGVGHASLDQLCQVTRARGLHS-KLTGAGGGGCGITL 343
E+ L EL+++N L ALGV H SL+++ +T L S KLTGAGGGGC ITL
Sbjct: 293 FFGAEERKKLRELVNINHGLLVALGVSHPSLEKVKIITDTSKLGSTKLTGAGGGGCAITL 352
Query: 344 LKPGLEQPEVEATKQALTSCGFDCLETSIGAPGV 377
+ + + ++ L G++C ETS+G GV
Sbjct: 353 VDEDVSEADIAQGIAELEKEGYECFETSLGGKGV 386
>ref|NP_001064360.1| Os10g0329300 [Oryza sativa (japonica cultivar-group)]
gb|ABB47176.1| Mevalonate kinase, putative, expressed [Oryza sativa (japonica
cultivar-group)]
dbj|BAF26274.1| Os10g0329300 [Oryza sativa (japonica cultivar-group)]
Length = 401
Score = 219 bits (558), Expect = 3e-55, Method: Composition-based stats.
Identities = 147/395 (37%), Positives = 224/395 (56%), Gaps = 27/395 (6%)
Query: 4 EVLLVSAPGKVILHGEHAVVHGKVALAVSLNL--RTFLRLQPHSN----GKVDLSLPNIG 57
EV APGK+IL GEHAVVHG A+A +++L R L L P ++ ++L L + G
Sbjct: 2 EVCAARAPGKIILAGEHAVVHGSAAVAAAIDLYTRCSLCLMPLADDEAAATLELDLKDPG 61
Query: 58 IKRAWDVARLQS-LDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTE-----RLAVLA 111
+ +W RL+ L T P S ++L +A L ++ + E + A
Sbjct: 62 LTFSWPCGRLREVLLTDEAAGAREARPCSP--DRLASIARLLEEHEIPEAKIWLSAGLSA 119
Query: 112 FLYLYLSI--CRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLT---VCEEIPN 166
FL+LY SI CR + + V S+LP G+GLGSSAA+ V ++ LLT V +
Sbjct: 120 FLFLYTSILGCRPGK------VTVSSDLPMGSGLGSSAAFCVSMSGVLLTAAGVVTAVGG 173
Query: 167 PLKDGDCVNRWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKR 226
+G K+DLEL+N+WAFQGE++IHG PSG+DNAVST+G +++ +G++++LK
Sbjct: 174 ISGEGMGWELVGKDDLELVNRWAFQGEKIIHGKPSGIDNAVSTFGSMIKFKKGELTNLKS 233
Query: 227 SPALQILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERV--LGEMGE 284
S +++L+T+T+V RNT+ALVAGV R + + +A + ++++IS E + L E
Sbjct: 234 SNPVKMLITDTRVGRNTKALVAGVSERASRHSDAMASVFNAVNSISEEVSSIVELAANDE 293
Query: 285 APAPEQYLVLEELIDMNQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLL 344
+ L EL++MNQ L +GV H+S++ + + T L SKLTGAGGGGC +TL+
Sbjct: 294 IAITSKEEKLAELMEMNQGLLQCMGVSHSSIETVLRTTLKFNLVSKLTGAGGGGCVLTLI 353
Query: 345 KPGLEQPEVEATKQALTSCGFDCLETSIGAPGVSI 379
L +E L S F C + +G G+ +
Sbjct: 354 PTMLSNLVLEKVIAELESHSFRCFKVEVGGQGLQV 388
>ref|XP_001231562.1| PREDICTED: hypothetical protein [Gallus gallus]
Length = 527
Score = 217 bits (553), Expect = 1e-54, Method: Composition-based stats.
Identities = 127/237 (53%), Positives = 154/237 (64%), Gaps = 31/237 (13%)
Query: 6 LLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKRAWDVA 65
LLVSAPGKVILHGEHAVVHGK ALAV+L LRTFLRL+P ++ + LP +G++R WDVA
Sbjct: 179 LLVSAPGKVILHGEHAVVHGKAALAVALGLRTFLRLRPGGGERLRIHLPGVGVRREWDVA 238
Query: 66 RLQSLDTSFLEQ-------------------------------GDVTTPTSEQVEKLKEV 94
L +L E + +P EQ++ LKE
Sbjct: 239 ELSALRGRLTEWFYVKPGVGLDDPYGCFPTWGVVGFFEPEADFDESKSPGVEQLDVLKEF 298
Query: 95 AGLPDDCAVTERLAVLAFLYLYLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLA 154
AG+ D + + LA+LAFLY+ L+I K +PS+DI VWSELP GAGLGSSAAY+VCLA
Sbjct: 299 AGIAADASAPDSLAILAFLYMCLAISAKYGDVPSVDIAVWSELPTGAGLGSSAAYAVCLA 358
Query: 155 AALLTVCEEIPNPLKDGDCVNRWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWG 211
AALL C I PLKDG+ RW +E++ LIN WAFQGER+IHGNPSGVDNAV TWG
Sbjct: 359 AALLHACRAISCPLKDGEATARWPEEEMSLINSWAFQGERVIHGNPSGVDNAVGTWG 415
Score = 114 bits (285), Expect = 1e-23, Method: Composition-based stats.
Identities = 63/98 (64%), Positives = 78/98 (79%)
Query: 296 ELIDMNQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEA 355
EL D+NQHHLN +GVGH SLD+LC+VT + GLHSKLTGAGGGGCGITLL P VEA
Sbjct: 427 ELFDINQHHLNVIGVGHPSLDRLCRVTASHGLHSKLTGAGGGGCGITLLPPDATPLAVEA 486
Query: 356 TKQALTSCGFDCLETSIGAPGVSIHSATSLDSRVQQAL 393
K+ L +CGF+C ET IGAPGV++HS+++L++ V AL
Sbjct: 487 AKRDLCACGFECWETDIGAPGVTLHSSSALNAEVLHAL 524
>ref|NP_592837.1| mevalonate kinase Erg12 (predicted) [Schizosaccharomyces pombe
972h-]
sp|Q09780|KIME_SCHPO Putative mevalonate kinase (MK)
emb|CAA91104.1| mevalonate kinase Erg12 (predicted) [Schizosaccharomyces pombe]
dbj|BAA25169.1| putative mevalonate kinase [Schizosaccharomyces pombe]
Length = 404
Score = 209 bits (533), Expect = 3e-52, Method: Composition-based stats.
Identities = 142/386 (36%), Positives = 214/386 (55%), Gaps = 21/386 (5%)
Query: 2 LSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKRA 61
+S+ L+VS+PGK IL GEHAVV+G ALA +++LR++ +LQ +N ++ + + +IG +R
Sbjct: 1 MSKSLIVSSPGKTILFGEHAVVYGATALAAAVSLRSYCKLQTTNNNEIVIVMSDIGTERR 60
Query: 62 WDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAG--LPDDCAVTERLAVLAFLYLYLSI 119
W+ LQSL + +V P S L + G L ++ A+L LYL+ S+
Sbjct: 61 WN---LQSLPWQHVTVENVQHPASSPNLDLLQGLGELLKNEENGLIHSAMLCTLYLFTSL 117
Query: 120 CRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTK 179
+ + + S++P GAGLGSSA SV +A +LL I P + N+
Sbjct: 118 SSPSQG---CTLTISSQVPLGAGLGSSATISVVVATSLLLAFGNIEPPSSNSLQNNK--- 171
Query: 180 EDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRY-----HQGKISS-LKRSPALQIL 233
L LI W+F GE IHG PSG+DNAV+T GG + + HQ + LK L ++
Sbjct: 172 -ALALIEAWSFLGECCIHGTPSGIDNAVATNGGLIAFRKATAHQSAMKEFLKPKDTLSVM 230
Query: 234 LTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLV 293
+T+TK P++T+ LV GV + P ++ ++ +ID IS VL E+
Sbjct: 231 ITDTKQPKSTKKLVQGVFELKERLPTVIDSIIDAIDGISKSA--VLALTSESDKNSSAKK 288
Query: 294 LEELIDMNQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEV 353
L E I +NQ L LGV H S+D++ Q T++ G +KLTGAGGGGC ITLL P ++ E
Sbjct: 289 LGEFIVLNQKLLECLGVSHYSIDRVLQATKSIGW-TKLTGAGGGGCTITLLTPECKEEEF 347
Query: 354 EATKQALTSCGFDCLETSIGAPGVSI 379
+ K++L + + +G PGVS+
Sbjct: 348 KLCKESLLAHKNSIYDVQLGGPGVSV 373
>ref|XP_961360.1| hypothetical protein NCU03633 [Neurospora crassa OR74A]
emb|CAC28692.1| related to MEVALONATE KINASE [Neurospora crassa]
gb|EAA32124.1| hypothetical protein NCU03633 [Neurospora crassa OR74A]
Length = 528
Score = 206 bits (525), Expect = 2e-51, Method: Composition-based stats.
Identities = 138/394 (35%), Positives = 213/394 (54%), Gaps = 24/394 (6%)
Query: 6 LLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGK--VDLSLPNIGIKRAWD 63
+VSAPGKVI+ GEHAVVHGK A+A +++LR++L + S K V L P+I +W+
Sbjct: 80 FMVSAPGKVIVFGEHAVVHGKAAIAAAISLRSYLLVNTLSKSKRTVTLKFPDIDFNHSWN 139
Query: 64 VARL-----QSLDTSFLEQGDVTTPTSEQVEKLKEVAG-----LPDDCAVTERLAVLAFL 113
+ L Q VT E V+ ++ P D + + +FL
Sbjct: 140 IDELPWKIFQQPGKKKYYYSLVTEIDQELVDAVQPFLADVSIDKPADIRKVHQNSAGSFL 199
Query: 114 YLYLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDC 173
Y++LS+ ++ P + S +P GAGLGSSA +VCL+AALL + P D
Sbjct: 200 YMFLSL--GSQSFPGCQYTLRSTIPIGAGLGSSATIAVCLSAALLLQLRTLSGPHPDQP- 256
Query: 174 VNRWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQG------KISSLKRS 227
+ +E IN+WAF E IHGNPSGVDN VST G A+ + + + L
Sbjct: 257 -PEEARLQIERINRWAFVYEMFIHGNPSGVDNTVSTQGKAVVFQRTDYNQPPSVRPLWDF 315
Query: 228 PALQILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPA 287
P L +LL +T+ ++T VA V K P++V +LT+ID ++ +++ E G
Sbjct: 316 PKLPLLLVDTRTAKSTAHEVAKVATLKKKHPQLVGTILTAIDQVTQSSAQLIEEQGFNTE 375
Query: 288 PEQYLV-LEELIDMNQHHLNALGVGHASLDQLCQVTRARGLH-SKLTGAGGGGCGITLLK 345
E+ L + E++ +N L +LGV H L+++ ++ G+ +KLTGAGGGGC ITLL+
Sbjct: 376 DEESLSKVGEMMTINHGLLVSLGVSHPRLERVRELVDHEGIGWTKLTGAGGGGCSITLLR 435
Query: 346 PGLEQPEVEATKQALTSCGFDCLETSIGAPGVSI 379
PG+ + +++ +Q L G+ ET++G+ GV +
Sbjct: 436 PGVPREKLDKLEQRLDEEGYSKFETTLGSDGVGV 469
>gb|EAW97871.1| mevalonate kinase (mevalonic aciduria), isoform CRA_b [Homo
sapiens]
Length = 115
Score = 206 bits (525), Expect = 2e-51, Method: Composition-based stats.
Identities = 115/115 (100%), Positives = 115/115 (100%)
Query: 282 MGEAPAPEQYLVLEELIDMNQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGI 341
MGEAPAPEQYLVLEELIDMNQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGI
Sbjct: 1 MGEAPAPEQYLVLEELIDMNQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGI 60
Query: 342 TLLKPGLEQPEVEATKQALTSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL 396
TLLKPGLEQPEVEATKQALTSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL
Sbjct: 61 TLLKPGLEQPEVEATKQALTSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL 115
>gb|AAL31086.1|AC091749_15 putative mevalonate kinase [Oryza sativa]
Length = 367
Score = 206 bits (525), Expect = 2e-51, Method: Composition-based stats.
Identities = 139/360 (38%), Positives = 212/360 (58%), Gaps = 27/360 (7%)
Query: 4 EVLLVSAPGKVILHGEHAVVHGKVALAVSLNL--RTFLRLQPHSNGK----VDLSLPNIG 57
EV APGK+IL GEHAVVHG A+A +++L R L L P ++ + ++L L + G
Sbjct: 2 EVCAARAPGKIILAGEHAVVHGSAAVAAAIDLYTRCSLCLMPLADDEAAATLELDLKDPG 61
Query: 58 IKRAWDVARLQS-LDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTE-----RLAVLA 111
+ +W RL+ L T P S ++L +A L ++ + E + A
Sbjct: 62 LTFSWPCGRLREVLLTDEAAGAREARPCSP--DRLASIARLLEEHEIPEAKIWLSAGLSA 119
Query: 112 FLYLYLSI--CRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLT---VCEEIPN 166
FL+LY SI CR + + V S+LP G+GLGSSAA+ V ++ LLT V +
Sbjct: 120 FLFLYTSILGCRPGK------VTVSSDLPMGSGLGSSAAFCVSMSGVLLTAAGVVTAVGG 173
Query: 167 PLKDGDCVNRWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKR 226
+G K+DLEL+N+WAFQGE++IHG PSG+DNAVST+G +++ +G++++LK
Sbjct: 174 ISGEGMGWELVGKDDLELVNRWAFQGEKIIHGKPSGIDNAVSTFGSMIKFKKGELTNLKS 233
Query: 227 SPALQILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERV--LGEMGE 284
S +++L+T+T+V RNT+ALVAGV R + + +A + ++++IS E + L E
Sbjct: 234 SNPVKMLITDTRVGRNTKALVAGVSERASRHSDAMASVFNAVNSISEEVSSIVELAANDE 293
Query: 285 APAPEQYLVLEELIDMNQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLL 344
+ L EL++MNQ L +GV H+S++ + + T L SKLTGAGGGGC +TL+
Sbjct: 294 IAITSKEEKLAELMEMNQGLLQCMGVSHSSIETVLRTTLKFNLVSKLTGAGGGGCVLTLI 353
>ref|XP_001836355.1| hypothetical protein CC1G_06440 [Coprinopsis cinerea okayama7#130]
gb|EAU85539.1| hypothetical protein CC1G_06440 [Coprinopsis cinerea okayama7#130]
Length = 914
Score = 202 bits (514), Expect = 4e-50, Method: Composition-based stats.
Identities = 153/398 (38%), Positives = 218/398 (54%), Gaps = 26/398 (6%)
Query: 7 LVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIG-IKRAWDVA 65
VSAPGKVIL GEHAVVHG A+A S++LR + P ++ K+ ++G WD+
Sbjct: 447 FVSAPGKVILFGEHAVVHGVTAIAASVDLRCYGLTTPRTDNKLSAHFKDLGNFYHEWDID 506
Query: 66 RLQSLDTSFLEQGDVTTPTSEQ--VEKLKE--VAGLPDDCAVTERLAVLAFLYLYLSICR 121
L + + G+ +Q +E L + +A L D+ R A LAFLYLY+++ R
Sbjct: 507 SLPWDALTPIPPGEEHPEELDQRLIEALSQSVLAELGDENK-QARAATLAFLYLYMTLAR 565
Query: 122 KQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDC------VN 175
Q PS + + LP GAGLGSSA++S C A ALL + I P K V+
Sbjct: 566 GQHR-PSFNFTARATLPVGAGLGSSASFSACAATALLLLHRRISVPAKPAPSTETHIHVS 624
Query: 176 RWTKEDL-----ELINKWAFQGERMIHGNPSGVDNAVSTWGGALRY------HQGKISSL 224
+ L E +N+WAF E+++HGNPSGVDN+V+ +GGAL Y +G + +
Sbjct: 625 HEGRRALPASVAEDVNRWAFVAEKILHGNPSGVDNSVAVFGGALAYTRPGFGKKGGMEQI 684
Query: 225 KRSPALQILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGE 284
+ +L+ LLTN++VPR+T+ LVAGV + PE+V +L +I +IS E R L + E
Sbjct: 685 QGFKSLKFLLTNSQVPRDTKKLVAGVGEKKENEPELVNGILAAIQSISDEARRALAD-PE 743
Query: 285 APAPEQYLVLEELIDMNQHHLNALGVGHASLDQLCQVT-RARGLHSKLTGAGGGGCGITL 343
L+ELI N HL LGV H SL+++ + T GL +KLTGAGGGGC +TL
Sbjct: 744 LSRDALLSALQELIKENHDHLVTLGVSHPSLEKIREKTSEPYGLKTKLTGAGGGGCAVTL 803
Query: 344 LKPGLEQPEVEATKQALTSCGFDCLETSIGAPGVSIHS 381
+ ++ + L GF TS+G G+ I S
Sbjct: 804 IPDDFKEEVLNGLIDELIREGFHPYLTSVGGSGLGILS 841
>ref|XP_001911734.1| unnamed protein product [Podospora anserina]
emb|CAP73562.1| unnamed protein product [Podospora anserina]
Length = 528
Score = 201 bits (510), Expect = 1e-49, Method: Composition-based stats.
Identities = 138/397 (34%), Positives = 211/397 (53%), Gaps = 30/397 (7%)
Query: 6 LLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGK--VDLSLPNIGIKRAWD 63
+VSAPGKVI+ GEHAVVHGK A+A S+ LR++L + S + V L P+I +W
Sbjct: 77 FMVSAPGKVIVFGEHAVVHGKAAIAASIALRSYLLVTSLSKSRKTVTLKFPDIDFDHSW- 135
Query: 64 VARLQSLDTSFLEQGD--------VTTPTSEQVEKLKEVAG-----LPDDCAVTERLAVL 110
R+ L + +Q VT E V ++ P D + +
Sbjct: 136 --RIDELPWAIFQQPSKKKYYYSLVTEIDQELVAAIQPYLADVSPDKPADVRKVHQNSAG 193
Query: 111 AFLYLYLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKD 170
+FLY++LS+ ++ P+ + S +P GAGLGSSA +VCL+AALL + P D
Sbjct: 194 SFLYMFLSL--GSQSFPACQYTLRSTIPIGAGLGSSATIAVCLSAALLLQLRTLSGPHPD 251
Query: 171 GDCVNRWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISS------L 224
+ +E IN+WA+ E IHGNPSGVDN VST G A+ + + S L
Sbjct: 252 QP--PEEARMQIERINRWAYVYEMFIHGNPSGVDNTVSTQGKAVMFQRTDYSKAPDVKPL 309
Query: 225 KRSPALQILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGE 284
P L +LL +T+ P++T VA V P++V +L +ID ++ ++ E
Sbjct: 310 WDFPELPLLLVDTRTPKSTAHEVAKVGRLKDTHPKLVGSILDAIDKVTQTSAELIAEDDF 369
Query: 285 APAPEQYLV-LEELIDMNQHHLNALGVGHASLDQLCQVTRARGLH-SKLTGAGGGGCGIT 342
+ E L + EL+++N L +LGV H L+++ ++ +G+ +KLTGAGGGGC IT
Sbjct: 370 STEKEDSLRRVGELMNINHGLLVSLGVSHPRLERVRELVDHQGIGWTKLTGAGGGGCSIT 429
Query: 343 LLKPGLEQPEVEATKQALTSCGFDCLETSIGAPGVSI 379
LLKPG+ + ++ ++ L G+ ET++G GV +
Sbjct: 430 LLKPGVPREKLARLEEQLDEEGYQRFETTLGGDGVGV 466
>ref|XP_001229023.1| hypothetical protein CHGG_02507 [Chaetomium globosum CBS 148.51]
gb|EAQ90572.1| hypothetical protein CHGG_02507 [Chaetomium globosum CBS 148.51]
Length = 532
Score = 200 bits (509), Expect = 2e-49, Method: Composition-based stats.
Identities = 141/394 (35%), Positives = 212/394 (53%), Gaps = 24/394 (6%)
Query: 6 LLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGK--VDLSLPNIGIKRAWD 63
+VSAPGKVI+ GEH+VVHGK A+A +++LR++L + S K V L P+I W+
Sbjct: 86 FMVSAPGKVIVFGEHSVVHGKAAIAAAISLRSYLLVTTLSKSKRTVTLKFPDIDFDHCWN 145
Query: 64 V-----ARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAG--LPDDCAVTERL---AVLAFL 113
+ A Q VT E V ++ PD A ++ + +FL
Sbjct: 146 IDELPWATFQQPSKKKYYYSLVTELDPELVAAIQPFLANVSPDKPAGIRKVHQNSAGSFL 205
Query: 114 YLYLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDC 173
Y++LS+ ++ P + S +P GAGLGSSA +VC++AALL + P D
Sbjct: 206 YMFLSL--GSQSFPGCQYTLRSTIPIGAGLGSSATIAVCMSAALLLQLRTLAGPHPDQPA 263
Query: 174 VNRWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQ---GKISSLK---RS 227
+ +E IN+WA+ E IHGNPSGVDN V+T G A+ + + GK S++
Sbjct: 264 DE--ARMQIERINRWAYVYEMFIHGNPSGVDNTVATQGKAVVFQRTDYGKPPSVRPLWDF 321
Query: 228 PALQILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPA 287
P L +LL +T+VP++T VA V P +V +L ++D ++ VL E G
Sbjct: 322 PELPLLLVDTRVPKSTAHEVAKVGKLKNTHPVLVGSILDAMDKVADASAEVLTEEGFDTQ 381
Query: 288 PEQYLV-LEELIDMNQHHLNALGVGHASLDQLCQVTRARGLH-SKLTGAGGGGCGITLLK 345
E L + EL+ +N L +LGV H L+++ ++ G+ +KLTGAGGGGC ITLLK
Sbjct: 382 SEASLARVGELMTVNHGLLVSLGVSHPRLERVRELVDHEGIGWTKLTGAGGGGCCITLLK 441
Query: 346 PGLEQPEVEATKQALTSCGFDCLETSIGAPGVSI 379
PG+E+ ++ + L GF+ ET++G GV +
Sbjct: 442 PGVERKKLRKLQAQLDEEGFEKFETTLGGDGVGV 475
Searching..................................................done
Results from round 2
Score E
Sequences producing significant alignments: (bits) Value
Sequences used in model and found again:
emb|CAA53059.1| unnamed protein product [Hepatitis B virus] 566 e-159
dbj|BAD92959.1| mevalonate kinase variant [Homo sapiens] 551 e-155
ref|XP_001105759.1| PREDICTED: mevalonate kinase isoform 2 ... 551 e-155
ref|NP_000422.1| mevalonate kinase [Homo sapiens] >gi|16700... 550 e-155
gb|AAQ02416.1| mevalonate kinase [synthetic construct] 550 e-155
ref|NP_001015528.1| mevalonate kinase [Bos taurus] >gi|7506... 510 e-143
ref|XP_543435.2| PREDICTED: similar to Mevalonate kinase (M... 510 e-143
gb|AAX08684.1| mevalonate kinase [Bos taurus] 510 e-143
ref|XP_001496887.1| PREDICTED: similar to mevalonate kinase... 509 e-142
gb|AAX46713.1| mevalonate kinase [Bos taurus] 494 e-138
ref|XP_001364115.1| PREDICTED: similar to mevalonate kinase... 484 e-135
ref|NP_076045.1| mevalonate kinase [Mus musculus] >gi|89281... 484 e-135
ref|NP_112325.1| mevalonate kinase [Rattus norvegicus] >gi|... 482 e-134
dbj|BAE28997.1| unnamed protein product [Mus musculus] 475 e-132
ref|XP_001105689.1| PREDICTED: mevalonate kinase isoform 1 ... 460 e-127
emb|CAM15186.1| novel protein similar to vertebrate mevalon... 414 e-114
ref|NP_001007350.1| hypothetical protein LOC492477 [Danio r... 414 e-114
ref|XP_918559.1| PREDICTED: similar to mevalonate kinase [M... 413 e-113
ref|XP_001911734.1| unnamed protein product [Podospora anse... 411 e-113
ref|XP_001229023.1| hypothetical protein CHGG_02507 [Chaeto... 408 e-112
ref|XP_961360.1| hypothetical protein NCU03633 [Neurospora ... 408 e-112
ref|XP_001593159.1| hypothetical protein SS1G_06081 [Sclero... 407 e-112
ref|XP_386088.1| hypothetical protein FG05912.1 [Gibberella... 404 e-111
ref|XP_661473.1| hypothetical protein AN3869.2 [Aspergillus... 403 e-110
ref|XP_001214601.1| conserved hypothetical protein [Aspergi... 403 e-110
ref|XP_001271672.1| mevalonate kinase [Aspergillus clavatus... 403 e-110
gb|EEH48028.1| mevalonate kinase [Paracoccidioides brasilie... 401 e-110
ref|XP_001821298.1| hypothetical protein [Aspergillus oryza... 401 e-110
emb|CAG08527.1| unnamed protein product [Tetraodon nigrovir... 401 e-110
ref|XP_001241830.1| hypothetical protein CIMG_05726 [Coccid... 401 e-110
ref|XP_001267243.1| mevalonate kinase [Neosartorya fischeri... 400 e-110
ref|XP_752047.1| mevalonate kinase [Aspergillus fumigatus A... 400 e-109
gb|EDP50156.1| mevalonate kinase [Aspergillus fumigatus A1163] 400 e-109
ref|XP_790690.1| PREDICTED: similar to Mevalonate kinase (M... 398 e-109
ref|XP_001559870.1| hypothetical protein BC1G_01429 [Botryo... 398 e-109
ref|XP_460851.1| hypothetical protein DEHA0F12188g [Debaryo... 395 e-108
ref|XP_723495.1| mevalonate kinase [Candida albicans SC5314... 395 e-108
ref|XP_001401587.1| hypothetical protein An04g02190 [Asperg... 394 e-108
ref|XP_370449.1| hypothetical protein MGG_06946 [Magnaporth... 393 e-107
ref|XP_001527900.1| hypothetical protein LELG_00420 [Lodder... 391 e-107
ref|XP_001382664.2| mevalonate kinase [Pichia stipitis CBS ... 386 e-105
gb|EEH37797.1| mevalonate kinase [Paracoccidioides brasilie... 372 e-101
ref|XP_001628178.1| predicted protein [Nematostella vectens... 360 8e-98
gb|AAD45421.1|L77688_1 mevalonate kinase [Arabidopsis thali... 356 2e-96
ref|NP_013935.1| Mevalonate kinase, acts in the biosynthesi... 356 2e-96
gb|EDN64144.1| mevalonate kinase [Saccharomyces cerevisiae ... 354 5e-96
ref|XP_001483309.1| hypothetical protein PGUG_04038 [Pichia... 354 8e-96
ref|NP_198097.1| MK/MVK; mevalonate kinase [Arabidopsis tha... 351 5e-95
gb|AAL18925.1|AF429384_1 mevalonate kinase [Hevea brasilien... 349 2e-94
gb|AAX46707.1| mevalonate kinase [Bos taurus] 348 5e-94
emb|CAO17636.1| unnamed protein product [Vitis vinifera] 346 2e-93
ref|XP_001779131.1| predicted protein [Physcomitrella paten... 344 8e-93
gb|ABK95983.1| unknown [Populus trichocarpa] 344 9e-93
ref|NP_001064360.1| Os10g0329300 [Oryza sativa (japonica cu... 342 4e-92
ref|NP_985191.1| AER335Wp [Ashbya gossypii ATCC 10895] >gi|... 340 1e-91
ref|XP_567851.1| cystathionine beta-lyase [Cryptococcus neo... 339 3e-91
ref|XP_567850.1| cystathionine beta-lyase [Cryptococcus neo... 338 4e-91
ref|XP_645383.1| hypothetical protein DDBDRAFT_0168621 [Dic... 338 7e-91
ref|XP_001846214.1| mevalonate kinase [Culex pipiens quinqu... 334 5e-90
ref|XP_001836355.1| hypothetical protein CC1G_06440 [Coprin... 334 1e-89
ref|XP_001657825.1| mevalonate kinase [Aedes aegypti] >gi|1... 332 4e-89
ref|XP_446138.1| unnamed protein product [Candida glabrata]... 330 1e-88
ref|XP_001644409.1| hypothetical protein Kpol_1064p33 [Vand... 328 4e-88
ref|NP_592837.1| mevalonate kinase Erg12 (predicted) [Schiz... 326 2e-87
ref|XP_500956.1| hypothetical protein [Yarrowia lipolytica]... 324 6e-87
ref|XP_452532.1| unnamed protein product [Kluyveromyces lac... 323 2e-86
ref|NP_001093299.1| mevalonate kinase [Bombyx mori] >gi|146... 321 5e-86
gb|ABD32397.1| Mevalonate and galactokinase [Medicago trunc... 321 9e-86
ref|XP_624545.2| PREDICTED: similar to Mevalonate kinase (M... 320 1e-85
ref|XP_001540400.1| conserved hypothetical protein [Ajellom... 320 1e-85
gb|EDU45497.1| mevalonate kinase [Pyrenophora tritici-repen... 314 7e-84
ref|XP_001608063.1| PREDICTED: similar to mevalonate kinase... 314 9e-84
gb|ABR68258.1| mevalonate kinase [Monodelphis domestica] 313 1e-83
ref|XP_761643.1| hypothetical protein UM05496.1 [Ustilago m... 311 5e-83
gb|AAL31086.1|AC091749_15 putative mevalonate kinase [Oryza... 309 3e-82
ref|XP_001730996.1| hypothetical protein MGL_1995 [Malassez... 308 6e-82
ref|XP_972334.1| PREDICTED: similar to mevalonate kinase [T... 299 3e-79
ref|NP_001027412.1| CG33671 CG33671-PA [Drosophila melanoga... 290 1e-76
ref|XP_319701.4| AGAP008947-PA [Anopheles gambiae str. PEST... 289 3e-76
ref|NP_126232.1| mevalonate kinase [Pyrococcus abyssi GE5] ... 286 2e-75
ref|YP_183887.1| mevalonate kinase [Thermococcus kodakarens... 284 9e-75
ref|NP_143478.1| mevalonate kinase [Pyrococcus horikoshii O... 282 3e-74
ref|NP_001022868.1| Y42G9A.4c [Caenorhabditis elegans] >gi|... 281 9e-74
ref|NP_001022869.1| Y42G9A.4d [Caenorhabditis elegans] >gi|... 279 3e-73
ref|NP_001022867.1| Y42G9A.4b [Caenorhabditis elegans] >gi|... 279 3e-73
ref|NP_579366.1| mevalonate kinase [Pyrococcus furiosus DSM... 273 2e-71
ref|XP_001900710.1| mevalonate kinase family protein [Brugi... 271 6e-71
gb|EAW97870.1| mevalonate kinase (mevalonic aciduria), isof... 265 3e-69
gb|EAZ05750.1| hypothetical protein OsI_026982 [Oryza sativ... 264 7e-69
ref|YP_658630.1| mevalonate kinase [Haloquadratum walsbyi D... 264 7e-69
ref|YP_920295.1| mevalonate kinase [Thermofilum pendens Hrk... 259 2e-67
gb|EAZ15677.1| hypothetical protein OsJ_029886 [Oryza sativ... 258 5e-67
emb|CAN77024.1| hypothetical protein [Vitis vinifera] 257 1e-66
gb|EAY78050.1| hypothetical protein OsI_032009 [Oryza sativ... 254 1e-65
ref|ZP_03999700.1| mevalonate kinase [Halogeometricum borin... 254 1e-65
ref|NP_633786.1| mevalonate kinase [Methanosarcina mazei Go... 251 6e-65
ref|YP_001040239.1| mevalonate kinase [Staphylothermus mari... 247 1e-63
ref|YP_447890.1| putative mevalonate kinase [Methanosphaera... 245 4e-63
ref|ZP_02015315.1| mevalonate kinase [Halorubrum lacusprofu... 244 1e-62
ref|YP_842907.1| mevalonate kinase [Methanosaeta thermophil... 244 1e-62
ref|YP_566996.1| mevalonate kinase [Methanococcoides burton... 243 2e-62
ref|YP_134862.1| mevalonate kinase [Haloarcula marismortui ... 242 4e-62
ref|YP_684687.1| mevalonate kinase [uncultured methanogenic... 237 2e-60
ref|YP_001581649.1| mevalonate kinase [Nitrosopumilus marit... 236 2e-60
ref|YP_327075.1| mevalonate kinase [Natronomonas pharaonis ... 235 3e-60
ref|NP_615566.1| mevalonate kinase [Methanosarcina acetivor... 232 3e-59
ref|YP_304960.1| mevalonate kinase [Methanosarcina barkeri ... 229 3e-58
ref|ZP_03943398.1| possible mevalonate kinase [Lactobacillu... 227 1e-57
ref|ZP_03940390.1| possible mevalonate kinase [Lactobacillu... 227 1e-57
ref|YP_001547075.1| mevalonate kinase [Herpetosiphon aurant... 227 2e-57
ref|YP_001276466.1| mevalonate kinase [Roseiflexus sp. RS-1... 227 2e-57
ref|NP_280049.1| Mvk [Halobacterium sp. NRC-1] >gi|16923595... 226 3e-57
pdb|1KKH|A Chain A, Crystal Structure Of The Methanococcus ... 225 5e-57
ref|NP_248080.1| mevalonate kinase [Methanocaldococcus jann... 225 6e-57
pdb|1VIS|A Chain A, Crystal Structure Of Mevalonate Kinase 224 7e-57
ref|ZP_03871887.1| mevalonate kinase [Halorhabdus utahensis... 224 1e-56
ref|YP_001634502.1| mevalonate kinase [Chloroflexus auranti... 224 1e-56
ref|ZP_03954541.1| possible mevalonate kinase [Lactobacillu... 224 1e-56
ref|YP_001013073.1| Mevalonate kinase [Hyperthermus butylic... 222 5e-56
gb|EDL19907.1| mevalonate kinase, isoform CRA_a [Mus muscul... 220 1e-55
ref|ZP_03873469.1| mevalonate kinase [Halomicrobium mukohat... 219 2e-55
ref|YP_001620791.1| mevalonate kinase [Acholeplasma laidlaw... 218 7e-55
ref|YP_001431846.1| mevalonate kinase [Roseiflexus castenho... 218 8e-55
ref|ZP_01695505.1| mevalonate kinase [Bacillus coagulans 36... 217 1e-54
ref|YP_804427.1| Mevalonate kinase [Pediococcus pentosaceus... 216 2e-54
ref|ZP_03980950.1| possible Mevalonate kinase [Enterococcus... 216 2e-54
ref|NP_814642.1| mevalonate kinase [Enterococcus faecalis V... 216 2e-54
ref|ZP_00604007.1| Mevalonate kinase [Enterococcus faecium ... 215 4e-54
gb|AAG02440.1|AF290093_1 mevalonate kinase [Enterococcus fa... 215 4e-54
ref|XP_001467381.1| mevalonate kinase [Leishmania infantum ... 215 4e-54
ref|XP_001567071.1| mevalonate kinase, putative [Leishmania... 215 4e-54
ref|ZP_03957037.1| mevalonate kinase [Lactobacillus ruminis... 215 7e-54
ref|XP_001325649.1| mevalonate kinase family protein [Trich... 214 9e-54
ref|YP_001056718.1| mevalonate kinase [Pyrobaculum calidifo... 213 2e-53
ref|ZP_03947872.1| mevalonate kinase [Enterococcus faecalis... 212 3e-53
ref|XP_001685041.1| mevalonate kinase, putative [Leishmania... 212 3e-53
pdb|2HFU|A Chain A, Crystal Structure Of L. Major Mevalonat... 212 4e-53
ref|XP_001794454.1| hypothetical protein SNOG_03909 [Phaeos... 211 6e-53
ref|YP_535578.1| Mevalonate kinase [Lactobacillus salivariu... 211 8e-53
ref|ZP_04008555.1| mevalonate kinase [Lactobacillus salivar... 210 2e-52
ref|ZP_01465063.1| mevalonate kinase [Stigmatella aurantiac... 210 2e-52
ref|YP_001274012.1| mevalonate kinase [Methanobrevibacter s... 210 2e-52
dbj|BAA24409.1| mevalonate kinase [Saccharomyces cerevisiae] 209 3e-52
ref|YP_795031.1| Mevalonate kinase [Lactobacillus brevis AT... 209 3e-52
ref|ZP_02185318.1| mevalonate kinase [Carnobacterium sp. AT... 209 3e-52
ref|YP_806709.1| Mevalonate kinase [Lactobacillus casei ATC... 208 4e-52
ref|ZP_03845964.1| mevalonate kinase [Lactobacillus sakei s... 208 5e-52
ref|YP_395519.1| Mevalonate kinase [Lactobacillus sakei sub... 208 8e-52
ref|NP_463543.1| hypothetical protein lmo0010 [Listeria mon... 207 1e-51
ref|YP_001540788.1| mevalonate kinase [Caldivirga maquiling... 207 1e-51
ref|ZP_02689018.1| mevalonate kinase [Listeria monocytogene... 207 1e-51
ref|YP_848214.1| mevalonate kinase [Listeria welshimeri ser... 207 1e-51
ref|YP_929988.1| mevalonate kinase [Pyrobaculum islandicum ... 207 2e-51
ref|XP_844557.1| mevalonate kinase, putative [Trypanosoma b... 206 2e-51
pdb|2HFS|A Chain A, Crystal Structure Of L. Major Mevalonat... 206 2e-51
ref|ZP_01942559.1| mevalonate kinase [Listeria monocytogene... 205 4e-51
ref|XP_001231562.1| PREDICTED: hypothetical protein [Gallus... 205 4e-51
ref|NP_614276.1| Mevalonate kinase [Methanopyrus kandleri A... 205 5e-51
ref|ZP_01926008.1| mevalonate kinase [Listeria monocytogene... 205 5e-51
sp|Q50559|KIME_METTH Mevalonate kinase (MK) >gi|1184118|gb|... 205 6e-51
ref|NP_469357.1| hypothetical protein lin0010 [Listeria inn... 205 7e-51
ref|YP_012624.1| mevalonate kinase [Listeria monocytogenes ... 205 7e-51
gb|EDM13938.1| mevalonate kinase, isoform CRA_b [Rattus nor... 204 9e-51
gb|EDM13939.1| mevalonate kinase, isoform CRA_c [Rattus nor... 203 2e-50
ref|NP_560495.1| mevalonate kinase [Pyrobaculum aerophilum ... 203 2e-50
ref|NP_691146.1| mevalonate kinase [Oceanobacillus iheyensi... 203 2e-50
ref|NP_275189.1| mevalonate kinase [Methanothermobacter the... 203 2e-50
ref|ZP_00230799.1| mevalonate kinase [Listeria monocytogene... 203 3e-50
ref|YP_001844008.1| mevalonate kinase [Lactobacillus fermen... 202 4e-50
ref|ZP_03944901.1| possible mevalonate kinase [Lactobacillu... 202 4e-50
ref|YP_001795021.1| mevalonate kinase [Thermoproteus neutro... 202 4e-50
ref|ZP_01906658.1| mevalonate kinase [Plesiocystis pacifica... 202 5e-50
ref|YP_001197657.1| Mevalonate kinase [Streptococcus suis 0... 201 9e-50
ref|YP_633174.1| mevalonate kinase [Myxococcus xanthus DK 1... 200 2e-49
ref|NP_266560.1| mevalonate kinase [Lactococcus lactis subs... 198 4e-49
ref|YP_001153805.1| mevalonate kinase [Pyrobaculum arsenati... 198 5e-49
ref|XP_001458185.1| hypothetical protein GSPATT00003653001 ... 198 6e-49
ref|ZP_00875673.1| Mevalonate kinase [Streptococcus suis 89... 198 9e-49
ref|YP_810664.1| Mevalonate kinase [Oenococcus oeni PSU-1] ... 197 2e-48
ref|ZP_03974667.1| mevalonate kinase [Lactobacillus reuteri... 196 3e-48
ref|ZP_01544345.1| mevalonate kinase [Oenococcus oeni ATCC ... 196 3e-48
ref|YP_001030120.1| hypothetical protein Mlab_0681 [Methano... 195 6e-48
ref|XP_802528.1| mevalonate kinase, putative [Trypanosoma c... 195 7e-48
ref|XP_814628.1| mevalonate kinase, putative [Trypanosoma c... 195 7e-48
ref|YP_001271514.1| mevalonate kinase [Lactobacillus reuter... 194 1e-47
ref|ZP_01514039.1| mevalonate kinase [Chloroflexus aggregan... 194 1e-47
ref|YP_818851.1| Mevalonate kinase [Leuconostoc mesenteroid... 193 1e-47
ref|ZP_03913910.1| mevalonate kinase [Leuconostoc mesentero... 193 2e-47
ref|YP_001329799.1| mevalonate kinase [Methanococcus maripa... 193 2e-47
ref|YP_001614848.1| hypothetical protein sce4205 [Sorangium... 192 5e-47
ref|YP_001096789.1| mevalonate kinase [Methanococcus maripa... 191 8e-47
ref|XP_001347016.1| Mevalonate kinase, putative [Paramecium... 191 1e-46
ref|NP_071114.1| mevalonate kinase (mvk) [Archaeoglobus ful... 190 2e-46
ref|YP_001549383.1| mevalonate kinase [Methanococcus maripa... 190 2e-46
ref|NP_645362.1| mevalonate kinase [Staphylococcus aureus s... 189 3e-46
ref|YP_040044.1| mevalonate kinase [Staphylococcus aureus s... 189 4e-46
gb|AAG02424.1|AF290087_1 mevalonate kinase [Staphylococcus ... 189 4e-46
ref|NP_988455.1| Mevalonate kinase [Methanococcus maripalud... 187 1e-45
ref|NP_720650.1| putative mevalonate kinase [Streptococcus ... 185 7e-45
ref|NP_785308.1| mevalonate kinase [Lactobacillus plantarum... 185 8e-45
ref|YP_302212.1| mevalonate kinase [Staphylococcus saprophy... 183 2e-44
ref|NP_819638.1| phosphomevalonate kinase, putative [Coxiel... 183 2e-44
ref|YP_598349.1| Mevalonate kinase [Streptococcus pyogenes ... 183 2e-44
ref|XP_001032429.2| DnaJ domain containing protein [Tetrahy... 182 5e-44
ref|ZP_01946351.1| mevalonate kinase [Coxiella burnetii 'MS... 182 5e-44
ref|XP_001708461.1| Mevalonate kinase [Giardia lamblia ATCC... 181 1e-43
emb|CAF88123.1| unnamed protein product [Tetraodon nigrovir... 179 3e-43
ref|NP_819639.1| mevalonate kinase, putative [Coxiella burn... 177 1e-42
ref|YP_001405370.1| mevalonate kinase [Candidatus Methanore... 177 1e-42
ref|NP_148611.1| mevalonate kinase [Aeropyrum pernix K1] >g... 177 2e-42
ref|YP_001435347.1| mevalonate kinase [Ignicoccus hospitali... 176 3e-42
ref|YP_001424028.1| putative phopshomevalonate kinase [Coxi... 175 5e-42
ref|YP_254317.1| mevalonate kinase [Staphylococcus haemolyt... 175 6e-42
ref|ZP_03882650.1| mevalonate kinase [Haliangium ochraceum ... 173 2e-41
ref|YP_504301.1| mevalonate kinase [Methanospirillum hungat... 173 2e-41
ref|NP_269075.1| mevalonate kinase [Streptococcus pyogenes ... 173 2e-41
ref|YP_280130.1| mevalonate kinase [Streptococcus pyogenes ... 172 6e-41
ref|NP_607080.1| mevalonate kinase [Streptococcus pyogenes ... 171 8e-41
ref|YP_060017.1| Mevalonate kinase [Streptococcus pyogenes ... 171 9e-41
ref|NP_664399.1| mevalonate kinase [Streptococcus pyogenes ... 171 1e-40
ref|YP_001209700.1| GHMP kinase family protein [Dichelobact... 169 4e-40
ref|YP_001737496.1| mevalonate kinase [Candidatus Korarchae... 168 6e-40
emb|CAD24422.1| phosphomevalonate kinase [Paracoccus zeaxan... 168 6e-40
ref|YP_001323164.1| mevalonate kinase [Methanococcus vannie... 168 9e-40
ref|ZP_01167630.1| GHMP kinase [Oceanospirillum sp. MED92] ... 166 3e-39
ref|XP_793882.1| PREDICTED: similar to mevalonate kinase va... 164 1e-38
ref|YP_391998.1| GHMP kinase [Thiomicrospira crunogena XCL-... 163 2e-38
ref|YP_876537.1| mevalonate kinase [Cenarchaeum symbiosum A... 160 1e-37
gb|ABG24208.1| mevalonate kinase [Arnebia euchroma] 160 2e-37
ref|ZP_01167629.1| mevalonate kinase, putative [Oceanospiri... 155 6e-36
ref|NP_001022866.1| Y42G9A.4a [Caenorhabditis elegans] >gi|... 155 6e-36
ref|NP_371114.1| mevalonate kinase [Staphylococcus aureus s... 155 8e-36
ref|XP_955731.1| mevalonate kinase [Encephalitozoon cunicul... 155 8e-36
ref|YP_001047720.1| mevalonate kinase [Methanoculleus maris... 153 2e-35
gb|ABR67422.1| mevalonate kinase 1 [Cucumis melo] 150 2e-34
ref|XP_001666415.1| hypothetical protein CBG21109 [Caenorha... 149 4e-34
gb|EAW97871.1| mevalonate kinase (mevalonic aciduria), isof... 148 9e-34
ref|YP_118418.1| putative mevalonate kinase [Nocardia farci... 146 2e-33
Sequences not found previously or not previously below threshold:
ref|YP_001031775.1| Mvk protein [Lactococcus lactis subsp. ... 195 4e-48
ref|YP_808480.1| Mevalonate kinase [Lactococcus lactis subs... 195 5e-48
ref|ZP_01273283.1| Mevalonate kinase [Lactobacillus reuteri... 190 2e-46
ref|ZP_03959183.1| possible mevalonate kinase [Lactobacillu... 189 3e-46
ref|YP_001727922.1| Mevalonate kinase [Leuconostoc citreum ... 180 1e-43
ref|YP_001034340.1| Mevalonate kinase, putative [Streptococ... 173 3e-41
ref|YP_001449558.1| mevalonate kinase [Streptococcus gordon... 172 6e-41
ref|ZP_02919501.1| hypothetical protein STRINF_00343 [Strep... 166 3e-39
ref|ZP_02193921.1| mevalonate kinase [Methanococcus voltae ... 165 7e-39
ref|ZP_03937041.1| possible mevalonate kinase [Gardnerella ... 165 7e-39
ref|XP_001423293.1| hypothetical protein GSPATT00000330001 ... 163 2e-38
ref|ZP_03951014.1| mevalonate kinase [Lactobacillus gasseri... 163 2e-38
ref|ZP_03859053.1| mevalonate kinase [Thermobaculum terrenu... 163 3e-38
ref|ZP_03808267.1| mevalonate kinase [Lactobacillus gasseri... 162 4e-38
ref|YP_814846.1| Mevalonate kinase [Lactobacillus gasseri A... 162 5e-38
ref|YP_001324970.1| mevalonate kinase [Methanococcus aeolic... 161 7e-38
ref|YP_001191681.1| mevalonate kinase [Metallosphaera sedul... 160 2e-37
ref|YP_139080.1| mevalonate kinase [Streptococcus thermophi... 160 2e-37
ref|YP_820062.1| Mevalonate kinase [Streptococcus thermophi... 160 3e-37
ref|YP_140970.1| mevalonate kinase [Streptococcus thermophi... 160 3e-37
ref|NP_688324.1| mevalonate kinase, putative [Streptococcus... 159 3e-37
ref|ZP_04007834.1| possible mevalonate kinase [Lactobacillu... 159 5e-37
dbj|BAD86800.1| mevalonate kinase [Streptomyces sp. KO-3988] 158 6e-37
ref|ZP_03807562.1| mevalonate kinase [Lactobacillus jenseni... 158 9e-37
ref|ZP_03956255.1| mevalonate kinase [Lactobacillus jenseni... 157 1e-36
ref|NP_378182.1| hypothetical protein ST2185 [Sulfolobus to... 157 1e-36
ref|YP_187834.1| mevalonate kinase [Staphylococcus epidermi... 156 3e-36
ref|NP_965060.1| mevalonate kinase [Lactobacillus johnsonii... 156 4e-36
gb|AAG02435.1|AF290091_1 mevalonate kinase [Staphylococcus ... 155 5e-36
dbj|BAB07790.1| mevalonate kinase [Streptomyces sp. CL190] 155 8e-36
ref|NP_341921.1| Mevalonate kinase [Sulfolobus solfataricus... 153 2e-35
ref|YP_256937.1| mevalonate kinase [Sulfolobus acidocaldari... 153 3e-35
ref|YP_812921.1| Mevalonate kinase [Lactobacillus delbrueck... 152 5e-35
ref|YP_618979.1| Mevalonate kinase [Lactobacillus delbrueck... 150 2e-34
ref|ZP_01817104.1| mevalonate kinase [Streptococcus pneumon... 148 1e-33
dbj|BAB07817.1| mevalonate kinase [Kitasatospora griseola] 148 1e-33
ref|YP_002741922.1| mevalonate kinase [Streptococcus pneumo... 146 2e-33
dbj|BAE78977.1| mevalonate kinase [Streptomyces sp. KO-3988] 146 2e-33
ref|ZP_02710031.1| mevalonate kinase [Streptococcus pneumon... 146 2e-33
ref|NP_344908.1| mevalonate kinase [Streptococcus pneumonia... 146 3e-33
ref|ZP_01819603.1| mevalonate kinase [Streptococcus pneumon... 146 4e-33
ref|ZP_03996582.1| mevalonate kinase [Lactobacillus crispat... 145 6e-33
gb|AAG02455.1|AF290099_1 mevalonate kinase [Streptococcus p... 145 6e-33
emb|CAL34097.1| putative mevalonate kinase [Streptomyces ci... 145 9e-33
ref|YP_002735468.1| mevalonate kinase [Streptococcus pneumo... 144 1e-32
ref|NP_357932.1| Mevalonate kinase [Streptococcus pneumonia... 144 2e-32
ref|ZP_03957035.1| phosphomevalonate kinase [Lactobacillus ... 143 2e-32
dbj|BAD07375.1| mevalonate kinase [Actinoplanes sp. A40644] 143 2e-32
ref|YP_001577580.1| Mevalonate kinase [Lactobacillus helvet... 143 2e-32
gb|ABH11598.1| GMP synthase, mevalonate kinase [Lactobacill... 143 3e-32
ref|YP_391999.1| GHMP kinase [Thiomicrospira crunogena XCL-... 141 9e-32
ref|ZP_03959181.1| phosphomevalonate kinase [Lactobacillus ... 140 3e-31
ref|ZP_01273285.1| Gram positive phosphomevalonate kinase [... 139 4e-31
ref|YP_001844010.1| phosphomevalonate kinase [Lactobacillus... 138 5e-31
ref|ZP_03974669.1| phosphomevalonate kinase [Lactobacillus ... 138 8e-31
ref|YP_535576.1| Phosphomevalonate kinase [Lactobacillus sa... 138 1e-30
ref|ZP_04012921.1| phosphomevalonate kinase [Lactobacillus ... 138 1e-30
ref|NP_785306.1| phosphomevalonate kinase [Lactobacillus pl... 137 2e-30
ref|YP_001851498.1| mevalonate kinase, Erg12 [Mycobacterium... 135 7e-30
gb|ABS50475.1| NapT6 [Streptomyces sp. CNQ525] 134 1e-29
ref|ZP_00780842.1| mevalonate kinase [Streptococcus agalact... 134 2e-29
ref|YP_806327.1| Phosphomevalonate kinase [Lactobacillus ca... 133 2e-29
>emb|CAA53059.1| unnamed protein product [Hepatitis B virus]
Length = 557
Score = 566 bits (1459), Expect = e-159, Method: Composition-based stats.
Identities = 396/396 (100%), Positives = 396/396 (100%)
Query: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 60
MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR
Sbjct: 162 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 221
Query: 61 AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC 120
AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC
Sbjct: 222 AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC 281
Query: 121 RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE 180
RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE
Sbjct: 282 RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE 341
Query: 181 DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP 240
DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP
Sbjct: 342 DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP 401
Query: 241 RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM 300
RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM
Sbjct: 402 RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM 461
Query: 301 NQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL 360
NQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL
Sbjct: 462 NQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL 521
Query: 361 TSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL 396
TSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL
Sbjct: 522 TSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL 557
>dbj|BAD92959.1| mevalonate kinase variant [Homo sapiens]
Length = 421
Score = 551 bits (1421), Expect = e-155, Method: Composition-based stats.
Identities = 395/396 (99%), Positives = 396/396 (100%)
Query: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 60
MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDL+LPNIGIKR
Sbjct: 26 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLNLPNIGIKR 85
Query: 61 AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC 120
AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC
Sbjct: 86 AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC 145
Query: 121 RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE 180
RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE
Sbjct: 146 RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE 205
Query: 181 DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP 240
DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP
Sbjct: 206 DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP 265
Query: 241 RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM 300
RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM
Sbjct: 266 RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM 325
Query: 301 NQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL 360
NQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL
Sbjct: 326 NQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL 385
Query: 361 TSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL 396
TSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL
Sbjct: 386 TSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL 421
>ref|XP_001105759.1| PREDICTED: mevalonate kinase isoform 2 [Macaca mulatta]
ref|XP_001105815.1| PREDICTED: mevalonate kinase isoform 3 [Macaca mulatta]
Length = 396
Score = 551 bits (1419), Expect = e-155, Method: Composition-based stats.
Identities = 381/396 (96%), Positives = 383/396 (96%)
Query: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 60
MLSEVLLVSAPGKVILHGEHAVVHGKVALAV+LNLRTFLRLQPHSNGKVDLSLPNIGIK
Sbjct: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVALNLRTFLRLQPHSNGKVDLSLPNIGIKW 60
Query: 61 AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC 120
AWDVARLQ LDTSFLEQGD TTPT E VEKLKEVAGLPDDCAVTE LAVLAFLYLYLSIC
Sbjct: 61 AWDVARLQLLDTSFLEQGDATTPTPELVEKLKEVAGLPDDCAVTESLAVLAFLYLYLSIC 120
Query: 121 RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE 180
RKQRALPSLDIVVWSELP GAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGD VNRWTKE
Sbjct: 121 RKQRALPSLDIVVWSELPHGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDRVNRWTKE 180
Query: 181 DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP 240
DLELINKWAFQGER+IHGNPSGVDNAVSTWGGALRY QGKISSLKR PALQILLTNTKVP
Sbjct: 181 DLELINKWAFQGERVIHGNPSGVDNAVSTWGGALRYQQGKISSLKRPPALQILLTNTKVP 240
Query: 241 RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM 300
RNTR LVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM
Sbjct: 241 RNTRTLVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM 300
Query: 301 NQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL 360
NQHHLNALGVGHASLDQLCQVTRA GLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL
Sbjct: 301 NQHHLNALGVGHASLDQLCQVTRAHGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL 360
Query: 361 TSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL 396
TSCGFDC ETSIGAPGVSIHSATSLDSRVQQALDGL
Sbjct: 361 TSCGFDCWETSIGAPGVSIHSATSLDSRVQQALDGL 396
>ref|NP_000422.1| mevalonate kinase [Homo sapiens]
ref|NP_001107657.1| mevalonate kinase [Homo sapiens]
sp|Q03426|KIME_HUMAN Mevalonate kinase (MK)
gb|AAB59362.1| mevalonate kinase
emb|CAA53060.1| unnamed protein product [Homo sapiens]
gb|AAF82407.1| mevalonate kinase [Homo sapiens]
gb|AAH16140.1| MVK protein [Homo sapiens]
gb|EAW97872.1| mevalonate kinase (mevalonic aciduria), isoform CRA_c [Homo
sapiens]
gb|EAW97873.1| mevalonate kinase (mevalonic aciduria), isoform CRA_c [Homo
sapiens]
gb|ABM82015.1| mevalonate kinase (mevalonic aciduria) [synthetic construct]
gb|ABM85197.1| mevalonate kinase (mevalonic aciduria) [synthetic construct]
Length = 396
Score = 550 bits (1418), Expect = e-155, Method: Composition-based stats.
Identities = 396/396 (100%), Positives = 396/396 (100%)
Query: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 60
MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR
Sbjct: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 60
Query: 61 AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC 120
AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC
Sbjct: 61 AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC 120
Query: 121 RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE 180
RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE
Sbjct: 121 RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE 180
Query: 181 DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP 240
DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP
Sbjct: 181 DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP 240
Query: 241 RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM 300
RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM
Sbjct: 241 RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM 300
Query: 301 NQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL 360
NQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL
Sbjct: 301 NQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL 360
Query: 361 TSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL 396
TSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL
Sbjct: 361 TSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL 396
>gb|AAQ02416.1| mevalonate kinase [synthetic construct]
Length = 397
Score = 550 bits (1418), Expect = e-155, Method: Composition-based stats.
Identities = 396/396 (100%), Positives = 396/396 (100%)
Query: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 60
MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR
Sbjct: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 60
Query: 61 AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC 120
AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC
Sbjct: 61 AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC 120
Query: 121 RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE 180
RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE
Sbjct: 121 RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE 180
Query: 181 DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP 240
DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP
Sbjct: 181 DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP 240
Query: 241 RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM 300
RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM
Sbjct: 241 RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM 300
Query: 301 NQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL 360
NQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL
Sbjct: 301 NQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL 360
Query: 361 TSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL 396
TSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL
Sbjct: 361 TSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL 396
>ref|NP_001015528.1| mevalonate kinase [Bos taurus]
sp|Q5E9T8|KIME_BOVIN Mevalonate kinase (MK)
gb|AAX08849.1| mevalonate kinase [Bos taurus]
gb|AAI04541.1| Mevalonate kinase (mevalonic aciduria) [Bos taurus]
Length = 396
Score = 510 bits (1315), Expect = e-143, Method: Composition-based stats.
Identities = 327/396 (82%), Positives = 352/396 (88%)
Query: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 60
MLSEVLLVSAPGKVILHGEHAVVHGKVALAV+LNLRTFLRLQPHSNG+V L+LPNIG++R
Sbjct: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVALNLRTFLRLQPHSNGRVGLNLPNIGVRR 60
Query: 61 AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC 120
AWDVA LQ LDTSFL GD T++ VEKLKEVAG P DC E LAVLAFLYLYLSIC
Sbjct: 61 AWDVASLQLLDTSFLGHGDSAALTAKHVEKLKEVAGFPKDCVDPEHLAVLAFLYLYLSIC 120
Query: 121 RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE 180
+ QRALPSLDI VWSELP GAGLGSSAAYSVCLAAALLT CEEIPNPLKDG+ RWT+E
Sbjct: 121 QSQRALPSLDITVWSELPTGAGLGSSAAYSVCLAAALLTACEEIPNPLKDGEAAGRWTEE 180
Query: 181 DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP 240
+LELINKWAFQGER+IHGNPSGVDNAVSTWGGALRY QGKISSLKR P L+ILL NTKVP
Sbjct: 181 NLELINKWAFQGERVIHGNPSGVDNAVSTWGGALRYQQGKISSLKRPPVLKILLINTKVP 240
Query: 241 RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM 300
R+T+ LVA VR+RLLKFPEIVAPLLTSIDAISLECERVLGEM AP PE YL LEELIDM
Sbjct: 241 RSTKVLVANVRSRLLKFPEIVAPLLTSIDAISLECERVLGEMAAAPTPEHYLTLEELIDM 300
Query: 301 NQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL 360
NQHHLNALGVGHASLDQLCQVT A GLHSKLTGAGGGGCGITLL+P +E+P VEATK+AL
Sbjct: 301 NQHHLNALGVGHASLDQLCQVTTAHGLHSKLTGAGGGGCGITLLRPDVERPAVEATKRAL 360
Query: 361 TSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL 396
+ CGFDC ETS+GAPGVS+H+A SLD+ VQQ LD L
Sbjct: 361 SGCGFDCWETSVGAPGVSVHTAASLDASVQQGLDSL 396
>ref|XP_543435.2| PREDICTED: similar to Mevalonate kinase (MK) [Canis familiaris]
Length = 409
Score = 510 bits (1313), Expect = e-143, Method: Composition-based stats.
Identities = 335/400 (83%), Positives = 359/400 (89%), Gaps = 4/400 (1%)
Query: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 60
MLSEVLLVSAPGKVILHGEHAVVHGK+ALAV+LNLRTFLRLQPHSNGK+ L+LPNIG+KR
Sbjct: 10 MLSEVLLVSAPGKVILHGEHAVVHGKIALAVALNLRTFLRLQPHSNGKMCLNLPNIGVKR 69
Query: 61 AWDVARLQSLDTSFLEQGDVTT----PTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLY 116
AWDVARLQ DTSFLE G+ T PTSEQVEKLKEVAG+P D A E LAVLAFLYLY
Sbjct: 70 AWDVARLQLQDTSFLEPGNATGDAAAPTSEQVEKLKEVAGIPKDGADPECLAVLAFLYLY 129
Query: 117 LSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNR 176
LSICRKQR LPSLDI VWSELP GAGLGSSAAYSVCLAAALLT CE IPNP +G+ +R
Sbjct: 130 LSICRKQRTLPSLDITVWSELPTGAGLGSSAAYSVCLAAALLTACEAIPNPQNNGESASR 189
Query: 177 WTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTN 236
WT EDLELINKWAFQGERMIHGNPSGVDN +STWGGALRY QGKISS+KR PAL+ILLTN
Sbjct: 190 WTMEDLELINKWAFQGERMIHGNPSGVDNTISTWGGALRYQQGKISSIKRLPALKILLTN 249
Query: 237 TKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEE 296
TKVPR+T+ALVA VR+RLLKFPEIVAPLLTSI+AISLECER L EM APAPE YLVLEE
Sbjct: 250 TKVPRSTKALVASVRSRLLKFPEIVAPLLTSINAISLECERTLEEMASAPAPEHYLVLEE 309
Query: 297 LIDMNQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEAT 356
LID+NQHHLNALGVGHASLDQLCQVT A GLHSKLTGAGGGGCGITLL+P LEQP+VEA
Sbjct: 310 LIDINQHHLNALGVGHASLDQLCQVTMAHGLHSKLTGAGGGGCGITLLRPDLEQPKVEAM 369
Query: 357 KQALTSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL 396
KQALTSCGFDC ET IGAPG+SIHSA SLD++VQ+ALDGL
Sbjct: 370 KQALTSCGFDCWETRIGAPGISIHSAASLDTQVQRALDGL 409
>gb|AAX08684.1| mevalonate kinase [Bos taurus]
Length = 396
Score = 510 bits (1313), Expect = e-143, Method: Composition-based stats.
Identities = 326/396 (82%), Positives = 351/396 (88%)
Query: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 60
MLSEVLLVSAPGKVILHGEHAVVHGKVALAV+LNLRTFLRLQPHSNG+V L+LPNIG++R
Sbjct: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVALNLRTFLRLQPHSNGRVGLNLPNIGVRR 60
Query: 61 AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC 120
AWDVA LQ LDTSFL GD T++ VEKLKEVAG P DC E LAVLAFLYLYLSIC
Sbjct: 61 AWDVASLQLLDTSFLGHGDSAALTAKHVEKLKEVAGFPKDCVDPEHLAVLAFLYLYLSIC 120
Query: 121 RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE 180
+ QR LPSLDI VWSELP GAGLGSSAAYSVCLAAALLT CEEIPNPLKDG+ RWT+E
Sbjct: 121 QSQRVLPSLDITVWSELPTGAGLGSSAAYSVCLAAALLTACEEIPNPLKDGEAAGRWTEE 180
Query: 181 DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP 240
+LELINKWAFQGER+IHGNPSGVDNAVSTWGGALRY QGKISSLKR P L+ILL NTKVP
Sbjct: 181 NLELINKWAFQGERVIHGNPSGVDNAVSTWGGALRYQQGKISSLKRPPVLKILLINTKVP 240
Query: 241 RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM 300
R+T+ LVA VR+RLLKFPEIVAPLLTSIDAISLECERVLGEM AP PE YL LEELIDM
Sbjct: 241 RSTKVLVANVRSRLLKFPEIVAPLLTSIDAISLECERVLGEMAAAPTPEHYLTLEELIDM 300
Query: 301 NQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL 360
NQHHLNALGVGHASLDQLCQVT A GLHSKLTGAGGGGCGITLL+P +E+P VEATK+AL
Sbjct: 301 NQHHLNALGVGHASLDQLCQVTTAHGLHSKLTGAGGGGCGITLLRPDVERPAVEATKRAL 360
Query: 361 TSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL 396
+ CGFDC ETS+GAPGVS+H+A SLD+ VQQ LD L
Sbjct: 361 SGCGFDCWETSVGAPGVSVHTAASLDASVQQGLDSL 396
>ref|XP_001496887.1| PREDICTED: similar to mevalonate kinase [Equus caballus]
Length = 407
Score = 509 bits (1312), Expect = e-142, Method: Composition-based stats.
Identities = 335/397 (84%), Positives = 360/397 (90%), Gaps = 1/397 (0%)
Query: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 60
MLSEVLLVSAPGKVILHGEHAVVHGKVALAV+LNLRTFLRLQPHS GKV L+LPNIGIK+
Sbjct: 11 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVALNLRTFLRLQPHSTGKVGLNLPNIGIKQ 70
Query: 61 AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTER-LAVLAFLYLYLSI 119
AWDVA LQ LDTSFLEQGD+T T EQVEKLKEVAG P+DCA + LAVLAFL+LYLSI
Sbjct: 71 AWDVASLQLLDTSFLEQGDITALTPEQVEKLKEVAGCPEDCANDHKWLAVLAFLFLYLSI 130
Query: 120 CRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTK 179
CRKQRALPSLD+ VWSELPPGAGLGSSAAYSVCLAAA L CEEIPNPLKDG+ +RWT+
Sbjct: 131 CRKQRALPSLDVTVWSELPPGAGLGSSAAYSVCLAAAFLAACEEIPNPLKDGEPTSRWTE 190
Query: 180 EDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKV 239
EDLELINKWAFQGER+IHGNPSGVDN VSTWGGALRY QGKISSLKR PAL+ILLTNTKV
Sbjct: 191 EDLELINKWAFQGERVIHGNPSGVDNTVSTWGGALRYQQGKISSLKRPPALKILLTNTKV 250
Query: 240 PRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELID 299
PR+T+ALVAGVRNRLLKFPEIVAP+LTSI+AISLECERVL EM AP P YLVLEELID
Sbjct: 251 PRSTKALVAGVRNRLLKFPEIVAPVLTSIEAISLECERVLAEMASAPTPGHYLVLEELID 310
Query: 300 MNQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQA 359
MNQHHLNALGVGHASLDQLCQVT A GLHSKLTG GGGGCGITLL+P L++ EVEA KQA
Sbjct: 311 MNQHHLNALGVGHASLDQLCQVTTAHGLHSKLTGGGGGGCGITLLRPDLQRLEVEAAKQA 370
Query: 360 LTSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL 396
LT CGFDC ETSIGAPGVS+H+ATSLD+ + QALDG+
Sbjct: 371 LTGCGFDCWETSIGAPGVSVHAATSLDAPILQALDGI 407
>gb|AAX46713.1| mevalonate kinase [Bos taurus]
Length = 440
Score = 494 bits (1273), Expect = e-138, Method: Composition-based stats.
Identities = 314/379 (82%), Positives = 338/379 (89%)
Query: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 60
MLSE LLVSAPGKVILHGEHAVVHGKVALA++LNLRTFLRLQPHSNG+V L+LPNIG++R
Sbjct: 1 MLSEALLVSAPGKVILHGEHAVVHGKVALAMALNLRTFLRLQPHSNGRVGLNLPNIGVRR 60
Query: 61 AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC 120
AWDVA LQ LDTSFL GD T++ VEKLKEVAG P DC E LAVLAFLYLYLSIC
Sbjct: 61 AWDVASLQLLDTSFLGHGDSAALTAKHVEKLKEVAGFPKDCVDPEHLAVLAFLYLYLSIC 120
Query: 121 RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE 180
+ QRALPSLDI VWSELP GAGLGSSAAYSVCLAAALLT CEEIPNPLKDG+ RWT+E
Sbjct: 121 QSQRALPSLDITVWSELPTGAGLGSSAAYSVCLAAALLTACEEIPNPLKDGEAAGRWTEE 180
Query: 181 DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP 240
+LELINKWAFQGER+IHGNPSGVDNAVSTWGGALRY QGKISSLKR P L+ILL NTKVP
Sbjct: 181 NLELINKWAFQGERVIHGNPSGVDNAVSTWGGALRYQQGKISSLKRPPVLKILLINTKVP 240
Query: 241 RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM 300
R+T+ LVA VR+RLLKFPEIVAPLLTSIDAISLECERVLGEM AP PE YL LEELIDM
Sbjct: 241 RSTKVLVANVRSRLLKFPEIVAPLLTSIDAISLECERVLGEMAAAPTPEHYLTLEELIDM 300
Query: 301 NQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL 360
NQHHLNALGVGHASLDQLCQVT A GLHSKLTGAGGGGCGITLL+P +E+PEVEATK+AL
Sbjct: 301 NQHHLNALGVGHASLDQLCQVTTAHGLHSKLTGAGGGGCGITLLRPDVERPEVEATKRAL 360
Query: 361 TSCGFDCLETSIGAPGVSI 379
+ GFDC ETS+GAPGVS+
Sbjct: 361 SGYGFDCWETSVGAPGVSV 379
>ref|XP_001364115.1| PREDICTED: similar to mevalonate kinase [Monodelphis domestica]
Length = 396
Score = 484 bits (1247), Expect = e-135, Method: Composition-based stats.
Identities = 287/396 (72%), Positives = 327/396 (82%)
Query: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 60
ML E LLVSAPGKVILHGEHAVVHGKVALA +LNLRTFLR++PH +GKV L LPN+ R
Sbjct: 1 MLPETLLVSAPGKVILHGEHAVVHGKVALAEALNLRTFLRMRPHKDGKVRLVLPNLETSR 60
Query: 61 AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC 120
WDV++LQ L SFL+ G+ T PT+EQVEKLK AG + E LAVLAFLYLYL IC
Sbjct: 61 EWDVSKLQLLHASFLDSGEPTAPTTEQVEKLKAFAGFMTGSSERECLAVLAFLYLYLFIC 120
Query: 121 RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE 180
RK R LPS+DIVVWSELP GAGLGSSAAYSVCLAAALL CEEI N LK+G RW ++
Sbjct: 121 RKHRPLPSMDIVVWSELPTGAGLGSSAAYSVCLAAALLASCEEIMNRLKEGATSARWNED 180
Query: 181 DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP 240
+L LIN+WAF GE++IHGNPSGVDN+VSTWGGALR+ +G ISSL+R P L+ILLTNTKVP
Sbjct: 181 ELNLINRWAFLGEKVIHGNPSGVDNSVSTWGGALRFQKGNISSLQRIPVLKILLTNTKVP 240
Query: 241 RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM 300
R+T+ALVA V++RL KFPEI+ PLL SIDAIS ECERVLG M P PEQY+VLEELIDM
Sbjct: 241 RSTKALVASVKDRLAKFPEIMNPLLVSIDAISQECERVLGVMAATPTPEQYMVLEELIDM 300
Query: 301 NQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL 360
NQHHLNA+GVGH+SLD+LCQVT A GLHSKLTGAGGGGCG TLL+PGL+Q VEA KQAL
Sbjct: 301 NQHHLNAIGVGHSSLDRLCQVTAAHGLHSKLTGAGGGGCGFTLLRPGLDQSVVEAIKQAL 360
Query: 361 TSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL 396
TSCGF+C ET+IG PGVS+HS SL + V QAL+ L
Sbjct: 361 TSCGFECWETTIGGPGVSLHSEASLKANVLQALNSL 396
>ref|NP_076045.1| mevalonate kinase [Mus musculus]
sp|Q9R008|KIME_MOUSE Mevalonate kinase (MK)
gb|AAF00700.1|AF137598_1 mevalonate kinase [Mus musculus]
gb|AAH05606.1| Mevalonate kinase [Mus musculus]
Length = 395
Score = 484 bits (1245), Expect = e-135, Method: Composition-based stats.
Identities = 319/393 (81%), Positives = 347/393 (88%)
Query: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 60
MLSE LLVSAPGKVILHGEHAVVHGKVALA +LNLRTFL L+P SNGKV ++LPNIGIK+
Sbjct: 1 MLSEALLVSAPGKVILHGEHAVVHGKVALAAALNLRTFLLLRPQSNGKVSVNLPNIGIKQ 60
Query: 61 AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC 120
WDV LQ LDTSFLEQGDV+ PT EQ+EKLK++ LP D A E +A+LAFLYLYL+IC
Sbjct: 61 VWDVGMLQRLDTSFLEQGDVSVPTLEQLEKLKKMGDLPRDRAGNEGMALLAFLYLYLAIC 120
Query: 121 RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE 180
RKQR LPSLD+VVWSELPPGAGLGSSAAYSVCLAAALLT CEE+ NPLKDG V+RW +E
Sbjct: 121 RKQRTLPSLDMVVWSELPPGAGLGSSAAYSVCLAAALLTACEEVSNPLKDGVSVSRWPEE 180
Query: 181 DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP 240
DL+ INKWAF+GER+IHGNPSGVDNAVSTWGGALR+ QG +SSLK P+LQILLTNTKVP
Sbjct: 181 DLKSINKWAFEGERVIHGNPSGVDNAVSTWGGALRFQQGTMSSLKSLPSLQILLTNTKVP 240
Query: 241 RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM 300
R+T+ALVA VR+RL KFPEIVAPLLTSIDAISLECERVLGEM AP PEQYLVLEELIDM
Sbjct: 241 RSTKALVAAVRSRLTKFPEIVAPLLTSIDAISLECERVLGEMVAAPVPEQYLVLEELIDM 300
Query: 301 NQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL 360
NQHHLNALGVGH SLDQLCQVT A GLHSKLTGAGGGGCGITLLKPGLEQ VEA KQAL
Sbjct: 301 NQHHLNALGVGHNSLDQLCQVTAAHGLHSKLTGAGGGGCGITLLKPGLEQATVEAAKQAL 360
Query: 361 TSCGFDCLETSIGAPGVSIHSATSLDSRVQQAL 393
TSCGFDC ETSIGAPGVS HSA ++ V+QAL
Sbjct: 361 TSCGFDCWETSIGAPGVSTHSAAAVGDPVRQAL 393
>ref|NP_112325.1| mevalonate kinase [Rattus norvegicus]
sp|P17256|KIME_RAT Mevalonate kinase (MK)
pdb|1KVK|A Chain A, The Structure Of Binary Complex Between A Mammalian
Mevalonate Kinase And Atp: Insights Into The Reaction
Mechanism And Human Inherited Disease
gb|AAA41588.1| mevalonate kinase (EC 2.7.1.36)
gb|EDM13937.1| mevalonate kinase, isoform CRA_a [Rattus norvegicus]
Length = 395
Score = 482 bits (1242), Expect = e-134, Method: Composition-based stats.
Identities = 322/393 (81%), Positives = 355/393 (90%)
Query: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 60
MLSEVLLVSAPGKVILHGEHAVVHGKVALAV+LNLRTFL L+P SNGKV L+LPN+GIK+
Sbjct: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVALNLRTFLVLRPQSNGKVSLNLPNVGIKQ 60
Query: 61 AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC 120
WDVA LQ LDT FLEQGDV PT EQ+EKLK+VAGLP DC E L++LAFLYLYL+IC
Sbjct: 61 VWDVATLQLLDTGFLEQGDVPAPTLEQLEKLKKVAGLPRDCVGNEGLSLLAFLYLYLAIC 120
Query: 121 RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE 180
RKQR LPSLDI+VWSELPPGAGLGSSAAYSVC+AAALLT CEE+ NPLKD + W +E
Sbjct: 121 RKQRTLPSLDIMVWSELPPGAGLGSSAAYSVCVAAALLTACEEVTNPLKDRGSIGSWPEE 180
Query: 181 DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP 240
DL+ INKWA++GER+IHGNPSGVDN+VSTWGGALRY QGK+SSLKR PALQILLTNTKVP
Sbjct: 181 DLKSINKWAYEGERVIHGNPSGVDNSVSTWGGALRYQQGKMSSLKRLPALQILLTNTKVP 240
Query: 241 RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM 300
R+T+ALVAGVR+RL+KFPEI+APLLTSIDAISLECERVLGEM AP PEQYLVLEEL+DM
Sbjct: 241 RSTKALVAGVRSRLIKFPEIMAPLLTSIDAISLECERVLGEMAAAPVPEQYLVLEELMDM 300
Query: 301 NQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL 360
NQHHLNALGVGHASLDQLCQVT A GLHSKLTGAGGGGCGITLLKPGLE+ +VEA KQAL
Sbjct: 301 NQHHLNALGVGHASLDQLCQVTAAHGLHSKLTGAGGGGCGITLLKPGLERAKVEAAKQAL 360
Query: 361 TSCGFDCLETSIGAPGVSIHSATSLDSRVQQAL 393
T CGFDC ETSIGAPGVS+HSATS++ V+QAL
Sbjct: 361 TGCGFDCWETSIGAPGVSMHSATSIEDPVRQAL 393
>dbj|BAE28997.1| unnamed protein product [Mus musculus]
Length = 407
Score = 475 bits (1224), Expect = e-132, Method: Composition-based stats.
Identities = 319/405 (78%), Positives = 347/405 (85%), Gaps = 12/405 (2%)
Query: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 60
MLSE LLVSAPGKVILHGEHAVVHGKVALA +LNLRTFL L+P SNGKV ++LPNIGIK+
Sbjct: 1 MLSEALLVSAPGKVILHGEHAVVHGKVALAAALNLRTFLLLRPQSNGKVSVNLPNIGIKQ 60
Query: 61 AWDVARLQSLDTSFL------------EQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLA 108
WDV LQ LDTSFL EQGDV+ PT EQ+EKLK++ LP D A E +A
Sbjct: 61 VWDVGMLQRLDTSFLGLSPTCLFARVTEQGDVSVPTLEQLEKLKKMGDLPRDRAGNEGMA 120
Query: 109 VLAFLYLYLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPL 168
+LAFLYLYL+ICRKQR LPSLD+VVWSELPPGAGLGSSAAYSVCLAAALLT CEE+ NPL
Sbjct: 121 LLAFLYLYLAICRKQRTLPSLDMVVWSELPPGAGLGSSAAYSVCLAAALLTACEEVSNPL 180
Query: 169 KDGDCVNRWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSP 228
KDG V+RW +EDL+ INKWAF+GER+IHGNPSGVDNAVSTWGGALR+ QG +SSLK P
Sbjct: 181 KDGVSVSRWPEEDLKSINKWAFEGERVIHGNPSGVDNAVSTWGGALRFQQGTMSSLKSLP 240
Query: 229 ALQILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAP 288
+LQILLTNTKVPR+T+ALVA VR+RL KFPEIVAPLLTSIDAISLECERVLGEM AP P
Sbjct: 241 SLQILLTNTKVPRSTKALVAAVRSRLTKFPEIVAPLLTSIDAISLECERVLGEMVAAPVP 300
Query: 289 EQYLVLEELIDMNQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGL 348
EQYLVLEELIDMNQHHLNALGVGH SLDQLCQVT A GLHSKLTGAGGGGCGITLLKPGL
Sbjct: 301 EQYLVLEELIDMNQHHLNALGVGHNSLDQLCQVTAAHGLHSKLTGAGGGGCGITLLKPGL 360
Query: 349 EQPEVEATKQALTSCGFDCLETSIGAPGVSIHSATSLDSRVQQAL 393
EQ VEA KQALTSCGFDC ETSIGAPGVS HSA ++ V+QAL
Sbjct: 361 EQATVEAAKQALTSCGFDCWETSIGAPGVSTHSAAAVGDPVRQAL 405
>ref|XP_001105689.1| PREDICTED: mevalonate kinase isoform 1 [Macaca mulatta]
Length = 344
Score = 460 bits (1183), Expect = e-127, Method: Composition-based stats.
Identities = 331/396 (83%), Positives = 333/396 (84%), Gaps = 52/396 (13%)
Query: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 60
MLSEVLLVSAPGKVILHGEHAVVHGKVALAV+LNLRTFLRLQPHSNGKVDLSLPNIGIK
Sbjct: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVALNLRTFLRLQPHSNGKVDLSLPNIGIKW 60
Query: 61 AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC 120
AWDVARLQ LDTSFLEQGD TTPT E VEKLKEVAGLPDDCAVTE LAVLAFLYLYLSIC
Sbjct: 61 AWDVARLQLLDTSFLEQGDATTPTPELVEKLKEVAGLPDDCAVTESLAVLAFLYLYLSIC 120
Query: 121 RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE 180
RKQ RWTKE
Sbjct: 121 RKQ----------------------------------------------------RWTKE 128
Query: 181 DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP 240
DLELINKWAFQGER+IHGNPSGVDNAVSTWGGALRY QGKISSLKR PALQILLTNTKVP
Sbjct: 129 DLELINKWAFQGERVIHGNPSGVDNAVSTWGGALRYQQGKISSLKRPPALQILLTNTKVP 188
Query: 241 RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM 300
RNTR LVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM
Sbjct: 189 RNTRTLVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM 248
Query: 301 NQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL 360
NQHHLNALGVGHASLDQLCQVTRA GLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL
Sbjct: 249 NQHHLNALGVGHASLDQLCQVTRAHGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL 308
Query: 361 TSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL 396
TSCGFDC ETSIGAPGVSIHSATSLDSRVQQALDGL
Sbjct: 309 TSCGFDCWETSIGAPGVSIHSATSLDSRVQQALDGL 344
>emb|CAM15186.1| novel protein similar to vertebrate mevalonate kinase (mevalonic
aciduria) (MVK) [Danio rerio]
Length = 396
Score = 414 bits (1065), Expect = e-114, Method: Composition-based stats.
Identities = 224/397 (56%), Positives = 294/397 (74%), Gaps = 4/397 (1%)
Query: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 60
M S L VSAPGKVILHGEH+VVHGKVALAVS+NLRT+LRLQ S+G+V ++LPNI
Sbjct: 1 MQSRELFVSAPGKVILHGEHSVVHGKVALAVSVNLRTYLRLQSTSSGQVCINLPNIDTFL 60
Query: 61 AWDVARLQSL-DTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSI 119
+W++ LQ L S EQ D ++ ++KL+E G+ DD T +AVLAFLY+Y+++
Sbjct: 61 SWEITALQPLLAGSKAEQRDPKELDADLLKKLREFTGISDDSTDTRSMAVLAFLYMYITV 120
Query: 120 CRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTK 179
+ +L S+ + VWSELP GAGLGSSAAY+VCL+AALL+ I L RW+K
Sbjct: 121 FAE--SLASITVSVWSELPTGAGLGSSAAYNVCLSAALLSARGNISPLLMAQQESARWSK 178
Query: 180 EDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKV 239
+++ELIN+WAF GE++IHGNPSGVDNAV TWGG LRYH G I+ L P L+ILLTNTKV
Sbjct: 179 DEMELINRWAFMGEKIIHGNPSGVDNAVGTWGGFLRYHSGNITPLSWVPILRILLTNTKV 238
Query: 240 PRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEA-PAPEQYLVLEELI 298
PR+T+ LV+GV++++ KFP ++ P+L S+ A+S CE+ L EM E P+ E Y +LEELI
Sbjct: 239 PRSTKVLVSGVKDKINKFPSVMRPVLESVSAVSCTCEQTLTEMAEHGPSAEHYNILEELI 298
Query: 299 DMNQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQ 358
D+NQHHLN +GVGH+SLD LC+VT ++GLHSKLTGAGGGGCGITLL+P + +++T +
Sbjct: 299 DINQHHLNVMGVGHSSLDTLCRVTLSKGLHSKLTGAGGGGCGITLLRPETDTSVIQSTVE 358
Query: 359 ALTSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDG 395
L +CGFDC ETSIGAPGV HS+ ++ V + L+
Sbjct: 359 ELKACGFDCWETSIGAPGVQQHSSAAISPDVLKILNS 395
>ref|NP_001007350.1| hypothetical protein LOC492477 [Danio rerio]
gb|AAH85528.1| Zgc:103473 [Danio rerio]
gb|AAI64491.1| Zgc:103473 protein [synthetic construct]
Length = 396
Score = 414 bits (1064), Expect = e-114, Method: Composition-based stats.
Identities = 224/397 (56%), Positives = 293/397 (73%), Gaps = 4/397 (1%)
Query: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 60
M S L VSAPGKVILHGEH+VVHGKVALAVS+NLRT+LRLQ S+G+V ++LPNI
Sbjct: 1 MQSRELFVSAPGKVILHGEHSVVHGKVALAVSVNLRTYLRLQSTSSGQVCINLPNIDTFL 60
Query: 61 AWDVARLQSL-DTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSI 119
+W++ LQ L S EQ D ++ ++KL+E G+ DD T +AVLAFLY+YL++
Sbjct: 61 SWEITALQPLLAGSKAEQRDPKELDADLLKKLREFTGISDDSTDTRSMAVLAFLYMYLTV 120
Query: 120 CRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTK 179
+ +L S+ + VWSELP GAGLGSSAAY+VCL+AALL+ I L RW+K
Sbjct: 121 FAE--SLASITVSVWSELPTGAGLGSSAAYNVCLSAALLSARGNISPLLMAQQESARWSK 178
Query: 180 EDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKV 239
+++ELIN+WAF GE++IHGNPSGVDNAV TWGG LRYH G I+ L P L+ILLTNTKV
Sbjct: 179 DEMELINRWAFMGEKIIHGNPSGVDNAVGTWGGFLRYHSGNITPLSWVPILRILLTNTKV 238
Query: 240 PRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEA-PAPEQYLVLEELI 298
PR+T+ LV+GV++++ KFP ++ P+L S+ A+S CE+ L EM E P+ E Y +LEELI
Sbjct: 239 PRSTKVLVSGVKDKINKFPSVMRPVLESVSAVSCTCEQTLTEMAEHGPSAEHYNILEELI 298
Query: 299 DMNQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQ 358
D+NQHHLN +GVGH+SLD LC+VT ++GLHSKLTGAGGGGCGITLL+P + +++ +
Sbjct: 299 DINQHHLNVMGVGHSSLDTLCRVTLSKGLHSKLTGAGGGGCGITLLRPETDTSVIQSAVE 358
Query: 359 ALTSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDG 395
L +CGFDC ETSIGAPGV HS+ ++ V + L+
Sbjct: 359 ELKACGFDCWETSIGAPGVQQHSSAAISPDVLKILNS 395
>ref|XP_918559.1| PREDICTED: similar to mevalonate kinase [Mus musculus]
Length = 382
Score = 413 bits (1061), Expect = e-113, Method: Composition-based stats.
Identities = 285/366 (77%), Positives = 315/366 (86%)
Query: 28 ALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKRAWDVARLQSLDTSFLEQGDVTTPTSEQ 87
ALA +LNLRTFL L+P SNGKV ++LPNIGIK+ WDV LQ LDTSFLEQGDV+ PT EQ
Sbjct: 15 ALAAALNLRTFLLLRPQSNGKVSVNLPNIGIKQVWDVGMLQRLDTSFLEQGDVSVPTLEQ 74
Query: 88 VEKLKEVAGLPDDCAVTERLAVLAFLYLYLSICRKQRALPSLDIVVWSELPPGAGLGSSA 147
+EKLK++ LP D A E +A+LAFLYLYL+ICRKQR LPSLD+VVWSELPPGAGLGSSA
Sbjct: 75 LEKLKKMGDLPRDRAGNEGMALLAFLYLYLAICRKQRTLPSLDMVVWSELPPGAGLGSSA 134
Query: 148 AYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKEDLELINKWAFQGERMIHGNPSGVDNAV 207
AYSVCLAAALLT CEE+ NPLKDG V+RW +EDL+ INKWAF+GER+IHGNPSGVDNA+
Sbjct: 135 AYSVCLAAALLTACEEVSNPLKDGVSVSRWPEEDLKSINKWAFEGERVIHGNPSGVDNAI 194
Query: 208 STWGGALRYHQGKISSLKRSPALQILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTS 267
STWG ++ + S L R P+LQILLTNTKVPR+T+ALVA VR+RL KFPEIVAPLLTS
Sbjct: 195 STWGKSVCSLSSRESRLSRLPSLQILLTNTKVPRSTKALVAAVRSRLTKFPEIVAPLLTS 254
Query: 268 IDAISLECERVLGEMGEAPAPEQYLVLEELIDMNQHHLNALGVGHASLDQLCQVTRARGL 327
IDAISLECERVLGEM AP PEQYLVLEELIDMNQHHLNALGVGH SLDQLCQVT A GL
Sbjct: 255 IDAISLECERVLGEMVAAPVPEQYLVLEELIDMNQHHLNALGVGHNSLDQLCQVTAAHGL 314
Query: 328 HSKLTGAGGGGCGITLLKPGLEQPEVEATKQALTSCGFDCLETSIGAPGVSIHSATSLDS 387
HSKLTGAGGGGCGITLLKPGLEQ VEA KQALTSCGFDC ETSIGAPGVS HSA ++
Sbjct: 315 HSKLTGAGGGGCGITLLKPGLEQATVEAAKQALTSCGFDCWETSIGAPGVSTHSAAAVGD 374
Query: 388 RVQQAL 393
V+QAL
Sbjct: 375 PVRQAL 380
>ref|XP_001911734.1| unnamed protein product [Podospora anserina]
emb|CAP73562.1| unnamed protein product [Podospora anserina]
Length = 528
Score = 411 bits (1058), Expect = e-113, Method: Composition-based stats.
Identities = 135/405 (33%), Positives = 208/405 (51%), Gaps = 24/405 (5%)
Query: 2 LSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGK--VDLSLPNIGIK 59
+ +VSAPGKVI+ GEHAVVHGK A+A S+ LR++L + S + V L P+I
Sbjct: 73 MMPSFMVSAPGKVIVFGEHAVVHGKAAIAASIALRSYLLVTSLSKSRKTVTLKFPDIDFD 132
Query: 60 RAWDVARLQSL-----DTSFLEQGDVTTPTSEQVEKLKEVA-----GLPDDCAVTERLAV 109
+W + L VT E V ++ P D + +
Sbjct: 133 HSWRIDELPWAIFQQPSKKKYYYSLVTEIDQELVAAIQPYLADVSPDKPADVRKVHQNSA 192
Query: 110 LAFLYLYLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLK 169
+FLY++LS+ ++ P+ + S +P GAGLGSSA +VCL+AALL + P
Sbjct: 193 GSFLYMFLSLGS--QSFPACQYTLRSTIPIGAGLGSSATIAVCLSAALLLQLRTLSGPHP 250
Query: 170 DGDCVNRWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQ------GKISS 223
D + +E IN+WA+ E IHGNPSGVDN VST G A+ + + +
Sbjct: 251 DQPP--EEARMQIERINRWAYVYEMFIHGNPSGVDNTVSTQGKAVMFQRTDYSKAPDVKP 308
Query: 224 LKRSPALQILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMG 283
L P L +LL +T+ P++T VA V P++V +L +ID ++ ++ E
Sbjct: 309 LWDFPELPLLLVDTRTPKSTAHEVAKVGRLKDTHPKLVGSILDAIDKVTQTSAELIAEDD 368
Query: 284 EAPAPEQ-YLVLEELIDMNQHHLNALGVGHASLDQLCQVTRARGLH-SKLTGAGGGGCGI 341
+ E + EL+++N L +LGV H L+++ ++ +G+ +KLTGAGGGGC I
Sbjct: 369 FSTEKEDSLRRVGELMNINHGLLVSLGVSHPRLERVRELVDHQGIGWTKLTGAGGGGCSI 428
Query: 342 TLLKPGLEQPEVEATKQALTSCGFDCLETSIGAPGVSIHSATSLD 386
TLLKPG+ + ++ ++ L G+ ET++G GV + L
Sbjct: 429 TLLKPGVPREKLARLEEQLDEEGYQRFETTLGGDGVGVLWPAVLK 473
>ref|XP_001229023.1| hypothetical protein CHGG_02507 [Chaetomium globosum CBS 148.51]
gb|EAQ90572.1| hypothetical protein CHGG_02507 [Chaetomium globosum CBS 148.51]
Length = 532
Score = 408 bits (1049), Expect = e-112, Method: Composition-based stats.
Identities = 136/405 (33%), Positives = 206/405 (50%), Gaps = 24/405 (5%)
Query: 2 LSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGK--VDLSLPNIGIK 59
+ +VSAPGKVI+ GEH+VVHGK A+A +++LR++L + S K V L P+I
Sbjct: 82 MMPAFMVSAPGKVIVFGEHSVVHGKAAIAAAISLRSYLLVTTLSKSKRTVTLKFPDIDFD 141
Query: 60 RAWDVARLQSL-----DTSFLEQGDVTTPTSEQVEKLKEVA-----GLPDDCAVTERLAV 109
W++ L VT E V ++ P + +
Sbjct: 142 HCWNIDELPWATFQQPSKKKYYYSLVTELDPELVAAIQPFLANVSPDKPAGIRKVHQNSA 201
Query: 110 LAFLYLYLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLK 169
+FLY++LS+ ++ P + S +P GAGLGSSA +VC++AALL + P
Sbjct: 202 GSFLYMFLSLGS--QSFPGCQYTLRSTIPIGAGLGSSATIAVCMSAALLLQLRTLAGPHP 259
Query: 170 DGDCVNRWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGK------ISS 223
D + +E IN+WA+ E IHGNPSGVDN V+T G A+ + + +
Sbjct: 260 DQPADE--ARMQIERINRWAYVYEMFIHGNPSGVDNTVATQGKAVVFQRTDYGKPPSVRP 317
Query: 224 LKRSPALQILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMG 283
L P L +LL +T+VP++T VA V P +V +L ++D ++ VL E G
Sbjct: 318 LWDFPELPLLLVDTRVPKSTAHEVAKVGKLKNTHPVLVGSILDAMDKVADASAEVLTEEG 377
Query: 284 EAPAPE-QYLVLEELIDMNQHHLNALGVGHASLDQLCQVTRARGLH-SKLTGAGGGGCGI 341
E + EL+ +N L +LGV H L+++ ++ G+ +KLTGAGGGGC I
Sbjct: 378 FDTQSEASLARVGELMTVNHGLLVSLGVSHPRLERVRELVDHEGIGWTKLTGAGGGGCCI 437
Query: 342 TLLKPGLEQPEVEATKQALTSCGFDCLETSIGAPGVSIHSATSLD 386
TLLKPG+E+ ++ + L GF+ ET++G GV + L
Sbjct: 438 TLLKPGVERKKLRKLQAQLDEEGFEKFETTLGGDGVGVLWPAVLK 482
>ref|XP_961360.1| hypothetical protein NCU03633 [Neurospora crassa OR74A]
emb|CAC28692.1| related to MEVALONATE KINASE [Neurospora crassa]
gb|EAA32124.1| hypothetical protein NCU03633 [Neurospora crassa OR74A]
Length = 528
Score = 408 bits (1048), Expect = e-112, Method: Composition-based stats.
Identities = 137/405 (33%), Positives = 212/405 (52%), Gaps = 24/405 (5%)
Query: 2 LSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGK--VDLSLPNIGIK 59
+ +VSAPGKVI+ GEHAVVHGK A+A +++LR++L + S K V L P+I
Sbjct: 76 MMPTFMVSAPGKVIVFGEHAVVHGKAAIAAAISLRSYLLVNTLSKSKRTVTLKFPDIDFN 135
Query: 60 RAWDVARLQS-----LDTSFLEQGDVTTPTSEQVEKLKEVA-----GLPDDCAVTERLAV 109
+W++ L VT E V+ ++ P D + +
Sbjct: 136 HSWNIDELPWKIFQQPGKKKYYYSLVTEIDQELVDAVQPFLADVSIDKPADIRKVHQNSA 195
Query: 110 LAFLYLYLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLK 169
+FLY++LS+ ++ P + S +P GAGLGSSA +VCL+AALL + P
Sbjct: 196 GSFLYMFLSLGS--QSFPGCQYTLRSTIPIGAGLGSSATIAVCLSAALLLQLRTLSGPHP 253
Query: 170 DGDCVNRWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGK------ISS 223
D + +E IN+WAF E IHGNPSGVDN VST G A+ + + +
Sbjct: 254 DQPP--EEARLQIERINRWAFVYEMFIHGNPSGVDNTVSTQGKAVVFQRTDYNQPPSVRP 311
Query: 224 LKRSPALQILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMG 283
L P L +LL +T+ ++T VA V K P++V +LT+ID ++ +++ E G
Sbjct: 312 LWDFPKLPLLLVDTRTAKSTAHEVAKVATLKKKHPQLVGTILTAIDQVTQSSAQLIEEQG 371
Query: 284 -EAPAPEQYLVLEELIDMNQHHLNALGVGHASLDQLCQVTRARGLH-SKLTGAGGGGCGI 341
E + E++ +N L +LGV H L+++ ++ G+ +KLTGAGGGGC I
Sbjct: 372 FNTEDEESLSKVGEMMTINHGLLVSLGVSHPRLERVRELVDHEGIGWTKLTGAGGGGCSI 431
Query: 342 TLLKPGLEQPEVEATKQALTSCGFDCLETSIGAPGVSIHSATSLD 386
TLL+PG+ + +++ +Q L G+ ET++G+ GV + L
Sbjct: 432 TLLRPGVPREKLDKLEQRLDEEGYSKFETTLGSDGVGVLWPAVLK 476
>ref|XP_001593159.1| hypothetical protein SS1G_06081 [Sclerotinia sclerotiorum 1980]
gb|EDO03600.1| hypothetical protein SS1G_06081 [Sclerotinia sclerotiorum 1980]
Length = 473
Score = 407 bits (1047), Expect = e-112, Method: Composition-based stats.
Identities = 138/398 (34%), Positives = 207/398 (52%), Gaps = 23/398 (5%)
Query: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGK--VDLSLPNIGI 58
M+ +VSAPGKVI+ GEHAVVHGK A+A +++LR++L + S K + L P+I +
Sbjct: 26 MMPP-FMVSAPGKVIVFGEHAVVHGKPAIAAAISLRSYLLVTALSKSKRTISLRFPDINL 84
Query: 59 KRAWDVARLQSL-----DTSFLEQGDVTTPTSEQVEKLKEVAG--LPDDC---AVTERLA 108
W++ L VT+ E V +K PD+ + +
Sbjct: 85 SHTWNIDDLPWSTFSHPSKKKYYYDQVTSLDPELVAAMKPHLENISPDESPSIRKIHQSS 144
Query: 109 VLAFLYLYLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPL 168
+FLY++LS+ ++ P + S +P GAGLGSSA+ SVCL++ALL + P
Sbjct: 145 ASSFLYIFLSLGS--QSFPGCLYTLRSTIPIGAGLGSSASISVCLSSALLLQIRTLSGPH 202
Query: 169 KDGDCVNRWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQ----GKISSL 224
D + LE IN+WAF GE IHGNPSGVDN VST G A+ Y + + L
Sbjct: 203 PDQP--SNEASLQLERINRWAFVGEMCIHGNPSGVDNTVSTQGKAVIYQKFPEGPTVKPL 260
Query: 225 KRSPALQILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMG- 283
+ P L +LL +T+ ++T VA V K P IV +L +ID + ++ +
Sbjct: 261 RDFPELPLLLVDTQQAKSTAHEVAKVGLLKEKHPAIVDSILDAIDMVGQSAAAMISDPNY 320
Query: 284 EAPAPEQYLVLEELIDMNQHHLNALGVGHASLDQLCQVTRARGLH-SKLTGAGGGGCGIT 342
++ E L +L+ +N L +LGV H L+++ ++ G+ +KLTGAGGGGC IT
Sbjct: 321 DSENIECVESLGKLMTINHGLLVSLGVSHPRLERIRELVDHEGIGWTKLTGAGGGGCSIT 380
Query: 343 LLKPGLEQPEVEATKQALTSCGFDCLETSIGAPGVSIH 380
LLKP + + L + G+ ET++G GV +
Sbjct: 381 LLKPDTTPERMARLEATLENEGYKKFETTLGCDGVGVL 418
>ref|XP_386088.1| hypothetical protein FG05912.1 [Gibberella zeae PH-1]
Length = 508
Score = 404 bits (1039), Expect = e-111, Method: Composition-based stats.
Identities = 130/405 (32%), Positives = 208/405 (51%), Gaps = 24/405 (5%)
Query: 2 LSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGK--VDLSLPNIGIK 59
++ +VSAPGKVI+ GEH+VVHGK A+A +++LR++L + S K V L +IG+
Sbjct: 57 MAPPFMVSAPGKVIVFGEHSVVHGKAAIAAAISLRSYLHVTTLSKSKRTVSLRFADIGLV 116
Query: 60 RAWDVARLQS-----LDTSFLEQGDVTTPTSEQVEKLKE-----VAGLPDDCAVTERLAV 109
W++ L VT + V ++ P++ +V
Sbjct: 117 HTWNIEDLPWEAFQQPSKKKSYYSLVTELDPDLVAAIQPHIEVVSPNHPEEIRRVHHSSV 176
Query: 110 LAFLYLYLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLK 169
AFLYL+LS+ + P + S +P GAGLGSSA+ SVCLA+ALL + P
Sbjct: 177 SAFLYLFLSLGSP--SFPPCLYTLRSTIPIGAGLGSSASVSVCLASALLLQLRTLSGPHP 234
Query: 170 DGDCVNRWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGK------ISS 223
D + +E IN+WAF E IHGNPSGVDN V+T G A+ + + +
Sbjct: 235 DQPADE--ARLQVERINRWAFVSEMCIHGNPSGVDNTVATQGKAVVFQRTDYSKPPNVRP 292
Query: 224 LKRSPALQILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMG 283
L P L +LL +T+ ++T VA V P++V +L ++D ++ ++ E
Sbjct: 293 LWDFPELPLLLVDTRQAKSTAHEVAKVAKLKQTHPKLVNSILDAMDKVTDAASELIEETS 352
Query: 284 -EAPAPEQYLVLEELIDMNQHHLNALGVGHASLDQLCQVTRARGLH-SKLTGAGGGGCGI 341
+ + E + EL+ +N L +LGV H L+++ ++ G+ +KLTGAGGGGC I
Sbjct: 353 FDNGSVEDLSKVGELMTINHGLLVSLGVSHPRLERVRELVDHEGIGWTKLTGAGGGGCSI 412
Query: 342 TLLKPGLEQPEVEATKQALTSCGFDCLETSIGAPGVSIHSATSLD 386
TLL+P + +++ ++ L + + ET++G G+ + L
Sbjct: 413 TLLRPDVPAEKLQKLEERLETENYAKFETTLGGDGIGVLWPAVLK 457
>ref|XP_661473.1| hypothetical protein AN3869.2 [Aspergillus nidulans FGSC A4]
gb|EAA59134.1| hypothetical protein AN3869.2 [Aspergillus nidulans FGSC A4]
Length = 735
Score = 403 bits (1036), Expect = e-110, Method: Composition-based stats.
Identities = 138/404 (34%), Positives = 206/404 (50%), Gaps = 24/404 (5%)
Query: 2 LSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNG--KVDLSLPNIGIK 59
L+ +VSAPGKVI++GEHAVVHGK A+A +++LR++L + S + L+ + +
Sbjct: 287 LAPAFMVSAPGKVIVYGEHAVVHGKAAMAAAISLRSYLLVTTLSKSQRTITLNFRDTNLN 346
Query: 60 RAWDVARLQS-----LDTSFLEQGDVTTPTSEQVEKLKE-----VAGLPDDCAVTERLAV 109
WD+ +L VTT E + ++ P++ + +
Sbjct: 347 HTWDIDQLPWDLFHHPSKKKYYYDLVTTLDQELYDAIQPHVEDISPDAPEEMRKIHKRSA 406
Query: 110 LAFLYLYLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLK 169
AFLYL+LS+ Q A + S +P GAGLGSSA+ VC++AALL + P
Sbjct: 407 SAFLYLFLSLGSPQSA--GAIYTLRSTIPIGAGLGSSASVCVCMSAALLVQIRTLAGPHP 464
Query: 170 DGDCVNRWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGK------ISS 223
D + +E IN+WAF GE IHGNPSGVDN VS G A+ + +G ++S
Sbjct: 465 DQPPDE--AEVQIERINRWAFVGEMCIHGNPSGVDNTVSAGGKAVIFRRGDYSKPPSVTS 522
Query: 224 LKRSPALQILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMG 283
L P L +LL +T+ R+T VA V ++P + +L +ID ++ E+V+ E
Sbjct: 523 LPTFPELPLLLVDTRQGRSTAVEVAKVGALRKEWPVVTESILDAIDNVTASAEKVIREPN 582
Query: 284 EAPAPEQ-YLVLEELIDMNQHHLNALGVGHASLDQLCQVTRARGLH-SKLTGAGGGGCGI 341
E+ L LI +N L +LGV H L+++ ++ + +KLTGAGGGGC I
Sbjct: 583 PEGLSEKTLQQLGTLIRINHGFLVSLGVSHPRLERIRELVDYADIGWTKLTGAGGGGCAI 642
Query: 342 TLLKPGLEQPEVEATKQALTSCGFDCLETSIGAPGVSIHSATSL 385
TLL+P L + K L F ET++G GV + L
Sbjct: 643 TLLRPDLNDDSLRQLKSQLQDENFGIYETTLGGDGVGVLWPAVL 686
>ref|XP_001214601.1| conserved hypothetical protein [Aspergillus terreus NIH2624]
gb|EAU34492.1| conserved hypothetical protein [Aspergillus terreus NIH2624]
Length = 541
Score = 403 bits (1035), Expect = e-110, Method: Composition-based stats.
Identities = 140/404 (34%), Positives = 207/404 (51%), Gaps = 24/404 (5%)
Query: 2 LSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNG--KVDLSLPNIGIK 59
L+ +VSAPGKVI+ GEHAVVHGK A+A +++LR++L + + V L+ +IG+
Sbjct: 92 LAPTFMVSAPGKVIVFGEHAVVHGKAAMAAAISLRSYLLVTTLTKSQRTVTLNFRDIGLA 151
Query: 60 RAWDVARLQS-----LDTSFLEQGDVTTPTSEQVEKLKEVA-----GLPDDCAVTERLAV 109
W++ L VT+ E V+ ++ LP+D R +
Sbjct: 152 HTWNIDDLPWDVFHQPAKKKYYYDLVTSLDPELVDAIQPYVDQVSPDLPEDQRKIHRRSA 211
Query: 110 LAFLYLYLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLK 169
AFLYL LS+ Q P + S +P GAGLGSSA+ VCL+AALL + P
Sbjct: 212 SAFLYLLLSLGSPQH--PGAIYTLRSTIPIGAGLGSSASVCVCLSAALLLQIRTLAGPHP 269
Query: 170 DGDCVNRWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGK------ISS 223
D + +E IN+WAF GE HGNPSGVDN VS G A+ + + + S
Sbjct: 270 DQPPDE--AEVQIERINRWAFVGEMCTHGNPSGVDNTVSAGGKAVIFRRTDYSKPPSVRS 327
Query: 224 LKRSPALQILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMG 283
L P L +LL +T+ PR+T VA V + P + +L +ID ++L E +L
Sbjct: 328 LPTFPELPLLLVDTRQPRSTAVEVAKVGKLKEEHPVVTESILDAIDKLTLSAEELLDGCE 387
Query: 284 EAPAPEQ-YLVLEELIDMNQHHLNALGVGHASLDQLCQVTRARGLH-SKLTGAGGGGCGI 341
+ E+ L L+ +N L +LGV H L+++ ++ + +KLTGAGGGGC I
Sbjct: 388 KTGVTEEVLERLGTLVRINHGFLVSLGVSHPRLERIRELVDFANIGWTKLTGAGGGGCAI 447
Query: 342 TLLKPGLEQPEVEATKQALTSCGFDCLETSIGAPGVSIHSATSL 385
TLL+P ++ V + L + GF ET++G G+ + L
Sbjct: 448 TLLRPDADKNAVRDLEAKLAAEGFAKYETTLGGDGIGVLWPAVL 491
>ref|XP_001271672.1| mevalonate kinase [Aspergillus clavatus NRRL 1]
gb|EAW10246.1| mevalonate kinase [Aspergillus clavatus NRRL 1]
Length = 536
Score = 403 bits (1035), Expect = e-110, Method: Composition-based stats.
Identities = 137/404 (33%), Positives = 209/404 (51%), Gaps = 24/404 (5%)
Query: 2 LSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNG--KVDLSLPNIGIK 59
++ +VSAPGKVI++GEHAVVHGK A+A +++LR++L + S V ++ +IG+
Sbjct: 85 MAPAFMVSAPGKVIVYGEHAVVHGKAAMAAAISLRSYLLVTTLSKSQRTVTMNFRDIGLD 144
Query: 60 RAWDVARLQS-----LDTSFLEQGDVTTPTSEQVEKLKE-----VAGLPDDCAVTERLAV 109
W++ L VT+ E V+ ++ P+D R +
Sbjct: 145 HTWNIDDLPWDVFHHPSKKKFYYNLVTSLDPELVDAIQPHVDAVSPDKPEDVRKIHRRSA 204
Query: 110 LAFLYLYLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLK 169
AFLYL+LS+ Q P + S +P GAGLGSSA+ VCL+AALL + P
Sbjct: 205 SAFLYLFLSLGSPQT--PGAIYTLRSTIPIGAGLGSSASVCVCLSAALLLQIRTLAGPHP 262
Query: 170 DGDCVNRWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKIS------S 223
D T+ +E IN+WAF GE HGNPSGVDN VS G A+ + + +
Sbjct: 263 DQPPDEAETQ--IERINRWAFVGEMCTHGNPSGVDNTVSAGGKAVIFRREDYTKPPTVIP 320
Query: 224 LKRSPALQILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMG 283
L P L +LL +T+ R+T A VA V P + +L +ID ++L + + ++
Sbjct: 321 LPNFPELPLLLVDTRQARSTAAEVAKVGKLKDDHPVVTEAILDAIDKVTLAAQEAIQDIN 380
Query: 284 EAPAPEQ-YLVLEELIDMNQHHLNALGVGHASLDQLCQVTRARGLH-SKLTGAGGGGCGI 341
Q L LI +N L +LGV H L+++ ++ + +KLTGAGGGGC I
Sbjct: 381 SKGVSAQILEHLGTLIRINHGFLVSLGVSHPRLERIRELVDYANIGWTKLTGAGGGGCAI 440
Query: 342 TLLKPGLEQPEVEATKQALTSCGFDCLETSIGAPGVSIHSATSL 385
T+L+P +++ V +Q L+ GF+ ET++G G+ + L
Sbjct: 441 TVLRPDVKEEAVRDLEQKLSVEGFEKYETTLGGDGIGVLWPAVL 484
>gb|EEH48028.1| mevalonate kinase [Paracoccidioides brasiliensis Pb18]
Length = 490
Score = 401 bits (1032), Expect = e-110, Method: Composition-based stats.
Identities = 133/405 (32%), Positives = 203/405 (50%), Gaps = 24/405 (5%)
Query: 2 LSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNG--KVDLSLPNIGIK 59
++ +VSAPGKVI+ GEHAVVHGK A+A +++LR++L + S + L+ +I +
Sbjct: 38 MAPAFMVSAPGKVIVFGEHAVVHGKRAMAAAISLRSYLLVTTLSKSQRTITLNFRDIELD 97
Query: 60 RAWDVARLQSL-----DTSFLEQGDVTTPTSEQVEKLKE-----VAGLPDDCAVTERLAV 109
W++ L VT+ E +E ++ G PD+ R +
Sbjct: 98 HTWNIDSLPWALFCQPSKKKFYYDSVTSLDPELLEAIQPHIADISIGKPDEVRKIHRSSA 157
Query: 110 LAFLYLYLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLK 169
AFLYL+LS+ + + S +P GAGLGSSA+ +VCL+AALL + P +
Sbjct: 158 TAFLYLFLSLSSPDS--HAAIYTLRSTIPIGAGLGSSASIAVCLSAALLLQIRILAGPHQ 215
Query: 170 DGDCVNRWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGK------ISS 223
D + +E IN+WAF GE IHGNPSGVDN VS G A+ + +G ++
Sbjct: 216 DQPP--EEAEVQIERINRWAFVGEMCIHGNPSGVDNTVSAGGKAVIFRRGDYSKPPSVTP 273
Query: 224 LKRSPALQILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMG 283
+ P L +LL N++ PR+T VA V P + L +ID ++ +
Sbjct: 274 ILDFPELPLLLVNSRQPRSTATEVAKVGRFCKAHPAVAESTLAAIDQVTESANNFIQSGR 333
Query: 284 -EAPAPEQYLVLEELIDMNQHHLNALGVGHASLDQLCQVTRARGLH-SKLTGAGGGGCGI 341
+ + E EL +N L +LGV H L+++ ++ G+ +KLTGAGGGGC I
Sbjct: 334 FDKDSNEDIDHFGELFRINHGLLVSLGVSHPRLERIRELVDHAGIGWTKLTGAGGGGCAI 393
Query: 342 TLLKPGLEQPEVEATKQALTSCGFDCLETSIGAPGVSIHSATSLD 386
LL+ Q + +Q L GF+ ET++G G+ + L
Sbjct: 394 VLLRANTNQAVLHHLEQNLDDEGFERYETTLGGNGIGVLWPAVLK 438
>ref|XP_001821298.1| hypothetical protein [Aspergillus oryzae RIB40]
dbj|BAE59296.1| unnamed protein product [Aspergillus oryzae]
Length = 534
Score = 401 bits (1031), Expect = e-110, Method: Composition-based stats.
Identities = 131/399 (32%), Positives = 207/399 (51%), Gaps = 24/399 (6%)
Query: 2 LSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNG--KVDLSLPNIGIK 59
++ +VSAPGKVI+ GEHAVVHGK A+A +++LR++L + + + L+ +IG+
Sbjct: 86 MAPAFMVSAPGKVIVFGEHAVVHGKAAMAAAISLRSYLLVTTLTKSQRTITLNFRDIGLN 145
Query: 60 RAWDVARLQS-----LDTSFLEQGDVTTPTSEQVEKLKEVA-----GLPDDCAVTERLAV 109
W + L VT+ E ++ + + LP+D +R A
Sbjct: 146 HTWSIDELPWDLFHQPTKKKYYYDLVTSIDPELLDAILPLVERISPDLPEDKRKHQRGAA 205
Query: 110 LAFLYLYLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLK 169
AFLYL+ ++ Q P + S +P GAGLGSSA+ VC++AALL + P
Sbjct: 206 TAFLYLFCALGSPQH--PGAIYTLRSTIPTGAGLGSSASICVCISAALLLQIRTLAGPHP 263
Query: 170 DGDCVNRWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGK------ISS 223
D + +E IN+WAF GE IHGNPSGVDN V+ G A+ + +G +SS
Sbjct: 264 DQPPDE--AEVQIERINRWAFVGEMCIHGNPSGVDNTVAAGGKAVIFRRGDYSKPPAVSS 321
Query: 224 LKRSPALQILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMG 283
L P L +LL +T+ R+T VA V + P + +L +I+ ++ + ++ E
Sbjct: 322 LPNFPELPLLLVDTRQSRSTAVEVAKVGQLKEEQPLVTEAILDTIEKVNASAQEIIRETD 381
Query: 284 EA-PAPEQYLVLEELIDMNQHHLNALGVGHASLDQLCQVTRARGLH-SKLTGAGGGGCGI 341
+ + + + LI +N L +LGV H L+++ ++ + +KLTGAGGGGC I
Sbjct: 382 SSGISKDTLERIGALIRINHGLLVSLGVSHPRLERIRELVDFANIGWTKLTGAGGGGCAI 441
Query: 342 TLLKPGLEQPEVEATKQALTSCGFDCLETSIGAPGVSIH 380
TLL+P + + ++ L GF ET++G GV +
Sbjct: 442 TLLRPDADPSAIRQLEEKLDEEGFAKYETTLGGDGVGVL 480
>emb|CAG08527.1| unnamed protein product [Tetraodon nigroviridis]
Length = 394
Score = 401 bits (1030), Expect = e-110, Method: Composition-based stats.
Identities = 223/390 (57%), Positives = 275/390 (70%), Gaps = 3/390 (0%)
Query: 6 LLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKRAWDVA 65
+ VSAPGK ILHGEHAVVHGKVALAVSLNLR++LRL+ S G V ++LPNI W+++
Sbjct: 6 IYVSAPGKAILHGEHAVVHGKVALAVSLNLRSYLRLEATSTGTVGVNLPNIDTFLHWNLS 65
Query: 66 RLQSLDTSFLEQ-GDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSICRKQR 124
L+ S G V + + +L+E G+ + T ++A L FLYLYLS
Sbjct: 66 ELKQFAPSVTGGTGQVKLLDPDLLRRLREYVGVANGNLNTSQMATLTFLYLYLS-AFGSG 124
Query: 125 ALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKEDLEL 184
LPSL + VWSELP GAGLGSSAAY+VCLAAALL I +PLK+ + RW +E+LEL
Sbjct: 125 ELPSLTVSVWSELPTGAGLGSSAAYTVCLAAALLCASGAISSPLKEWEHTARWCQEELEL 184
Query: 185 INKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVPRNTR 244
IN WAFQGE +IHGNPSGVDNAV TWGG LR+ GKI L R P L+ILLTNTKVPR+T+
Sbjct: 185 INSWAFQGEMIIHGNPSGVDNAVGTWGGMLRFLAGKIIPLSRVPLLRILLTNTKVPRSTK 244
Query: 245 ALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEM-GEAPAPEQYLVLEELIDMNQH 303
LV+ V++++ KFP ++AP+L S+DAIS CE+VL EM E E Y LEELID+NQH
Sbjct: 245 VLVSRVKDKINKFPSVMAPVLDSVDAISCTCEKVLSEMTSEPITGEHYNALEELIDINQH 304
Query: 304 HLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQALTSC 363
HLN +GVGH +LD LC++T +GLHSKLTGAGGGGCGITLL+P V+AT Q L C
Sbjct: 305 HLNVMGVGHPALDTLCRITLTKGLHSKLTGAGGGGCGITLLRPETGSAVVQATVQDLKDC 364
Query: 364 GFDCLETSIGAPGVSIHSATSLDSRVQQAL 393
GFDC ETSIG PGV H+ S+ + + L
Sbjct: 365 GFDCWETSIGGPGVQQHAPVSVKEEILEVL 394
>ref|XP_001241830.1| hypothetical protein CIMG_05726 [Coccidioides immitis RS]
gb|EAS30247.1| hypothetical protein CIMG_05726 [Coccidioides immitis RS]
Length = 612
Score = 401 bits (1030), Expect = e-110, Method: Composition-based stats.
Identities = 133/405 (32%), Positives = 201/405 (49%), Gaps = 24/405 (5%)
Query: 2 LSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGK--VDLSLPNIGIK 59
++ +VSAPGKVI+ GEHAVVHGK A+A +++LR++L + S + V L+ + G+
Sbjct: 163 MAPPFMVSAPGKVIVFGEHAVVHGKKAMAAAISLRSYLLVTTLSKSRRTVTLNFRDTGLD 222
Query: 60 RAWDVARLQS-----LDTSFLEQGDVTTPTSEQVEKLKE-----VAGLPDDCAVTERLAV 109
WD+ L VT+ + ++ ++ P + + +
Sbjct: 223 HTWDIDSLPWDVFNHSSKKKFYYDRVTSLDPDLLDAIRPHISNVSPDKPPEVRKVHQGSA 282
Query: 110 LAFLYLYLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLK 169
AFLYLYLS+ Q + S +P GAGLGSSA+ VCL+AALL + P
Sbjct: 283 SAFLYLYLSLGSPQS--HGAIYTLRSTIPIGAGLGSSASVCVCLSAALLLQIRALAGPHP 340
Query: 170 DGDCVNRWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKIS------S 223
D ++ +E IN+WAF GE IHGNPSGVDN VS G A+ + +G S
Sbjct: 341 DQPFDE--SEVQIERINRWAFVGELCIHGNPSGVDNTVSAGGKAVIFRRGDYSKPPTVIP 398
Query: 224 LKRSPALQILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVL-GEM 282
+ P L +LL N++ R+T VA V P I LL ID ++ + E
Sbjct: 399 ILDFPELPLLLVNSRQSRSTATEVAKVGTLKKLHPAITDCLLDGIDQVTTSAHDFISSEN 458
Query: 283 GEAPAPEQYLVLEELIDMNQHHLNALGVGHASLDQLCQVTRARGLH-SKLTGAGGGGCGI 341
+ + E L +N L +LGV H L+++ ++ G+ +KLTGAGGGGC I
Sbjct: 459 FDKNSSETLNYFGTLFRINHGLLVSLGVSHPRLERIRELVDHTGIGWTKLTGAGGGGCAI 518
Query: 342 TLLKPGLEQPEVEATKQALTSCGFDCLETSIGAPGVSIHSATSLD 386
TL++ E ++ ++ L G++ ET++G GV + L
Sbjct: 519 TLIRTDRESTALKPLERQLDEEGYERYETTLGGQGVGVLWPAVLK 563
>ref|XP_001267243.1| mevalonate kinase [Neosartorya fischeri NRRL 181]
gb|EAW25346.1| mevalonate kinase [Neosartorya fischeri NRRL 181]
Length = 538
Score = 400 bits (1029), Expect = e-110, Method: Composition-based stats.
Identities = 136/404 (33%), Positives = 209/404 (51%), Gaps = 24/404 (5%)
Query: 2 LSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNG--KVDLSLPNIGIK 59
++ +VSAPGKVI++GEHAVVHGK A+A +++LR++L + S + ++ +IG+
Sbjct: 88 MAPAFMVSAPGKVIVYGEHAVVHGKAAMAAAISLRSYLLVTTLSKSQRTITMNFRDIGLD 147
Query: 60 RAWDVARLQS-----LDTSFLEQGDVTTPTSEQVEKLKEVAGL-----PDDCAVTERLAV 109
W++ L VT+ E V ++ A P+D R +
Sbjct: 148 HTWNIDELPWDVFHHPSKKKFYYDLVTSLDPELVAAIQPHADAVSPEKPEDVRKIHRRSA 207
Query: 110 LAFLYLYLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLK 169
AFLYL+LS+ Q P + S +P GAGLGSSA+ VCL+AALL + P
Sbjct: 208 SAFLYLFLSLGSSQN--PGAIYTLRSTIPIGAGLGSSASVCVCLSAALLLQIRTLAGPHP 265
Query: 170 DGDCVNRWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGK------ISS 223
D + +E IN+WAF GE HGNPSGVDN VS G A+ + + ++
Sbjct: 266 DQPPDE--AEVQIERINRWAFVGEMCTHGNPSGVDNTVSAGGKAVVFRREDYSKPPTVTP 323
Query: 224 LKRSPALQILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMG 283
L P L +LL +T+ R+T VA V + P + +L +ID ++L ++ + E+
Sbjct: 324 LLNFPELPLLLVDTRQSRSTAVEVAKVGKLKDEHPVVADSILEAIDQVTLAAQQKIQEIS 383
Query: 284 EAPAPEQ-YLVLEELIDMNQHHLNALGVGHASLDQLCQVTRARGLH-SKLTGAGGGGCGI 341
E+ L LI +N L +LGV H L+++ ++ + +KLTGAGGGGC I
Sbjct: 384 TNGISERTLEDLGTLIRINHGFLVSLGVSHPRLERIRELVDYADIGWTKLTGAGGGGCAI 443
Query: 342 TLLKPGLEQPEVEATKQALTSCGFDCLETSIGAPGVSIHSATSL 385
TLL+P ++ V ++ L + GF ET++G G+ + L
Sbjct: 444 TLLRPDTKEEAVRELEEKLNAEGFVKYETTLGGDGIGVLWPAVL 487
>ref|XP_752047.1| mevalonate kinase [Aspergillus fumigatus Af293]
gb|EAL90009.1| mevalonate kinase [Aspergillus fumigatus Af293]
Length = 538
Score = 400 bits (1027), Expect = e-109, Method: Composition-based stats.
Identities = 135/404 (33%), Positives = 211/404 (52%), Gaps = 24/404 (5%)
Query: 2 LSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNG--KVDLSLPNIGIK 59
++ +VSAPGKVI++GEHAVVHGK A+A +++LR++L + S + ++ +IG+
Sbjct: 88 MAPAFMVSAPGKVIVYGEHAVVHGKAAMAAAISLRSYLLVTTLSKSQRTITMNFRDIGLD 147
Query: 60 RAWDVARLQS-----LDTSFLEQGDVTTPTSEQVEKLKEVAGL-----PDDCAVTERLAV 109
W++ L VT+ E V ++ A P+D R +
Sbjct: 148 HTWNIDELPWDVFHHPSKKKFYYDLVTSLDPELVAAIQPHADAVSPDKPEDVRKIHRRSA 207
Query: 110 LAFLYLYLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLK 169
AFLYL+LS+ Q P + S +P GAGLGSSA+ VCL+AALL + P
Sbjct: 208 SAFLYLFLSLGSSQN--PGAIYTLRSTIPIGAGLGSSASVCVCLSAALLLQIRTLAGPHP 265
Query: 170 DGDCVNRWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGK------ISS 223
D + +E IN+WAF GE HGNPSGVDN VS G A+ + + ++
Sbjct: 266 DQPPDE--AEVQIERINRWAFVGEMCTHGNPSGVDNTVSAGGKAVVFRREDYSKPPTVTP 323
Query: 224 LKRSPALQILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMG 283
L P L +LL +T+ R+T VA V ++P + +L +ID ++L ++ + E+
Sbjct: 324 LLNFPELPLLLVDTRQSRSTAVEVAKVGKLKDEYPVVTDSILEAIDQVTLAAQQKIQEIS 383
Query: 284 EA-PAPEQYLVLEELIDMNQHHLNALGVGHASLDQLCQVTRARGLH-SKLTGAGGGGCGI 341
+ L LI +N L +LGV H L+++ ++ + +KLTGAGGGGC I
Sbjct: 384 TNGISYRTLEDLGTLIRINHGFLVSLGVSHPRLERIRELVDYADIGWTKLTGAGGGGCAI 443
Query: 342 TLLKPGLEQPEVEATKQALTSCGFDCLETSIGAPGVSIHSATSL 385
TLL+P +++ V ++ L++ GF ET++G G+ + L
Sbjct: 444 TLLRPDIKEEAVRELEEKLSAEGFVKYETTLGGDGIGVLWPAVL 487
>gb|EDP50156.1| mevalonate kinase [Aspergillus fumigatus A1163]
Length = 538
Score = 400 bits (1027), Expect = e-109, Method: Composition-based stats.
Identities = 135/404 (33%), Positives = 211/404 (52%), Gaps = 24/404 (5%)
Query: 2 LSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNG--KVDLSLPNIGIK 59
++ +VSAPGKVI++GEHAVVHGK A+A +++LR++L + S + ++ +IG+
Sbjct: 88 MAPAFMVSAPGKVIVYGEHAVVHGKAAMAAAISLRSYLLVTTLSKSQRTITMNFRDIGLD 147
Query: 60 RAWDVARLQS-----LDTSFLEQGDVTTPTSEQVEKLKEVAGL-----PDDCAVTERLAV 109
W++ L VT+ E V ++ A P+D R +
Sbjct: 148 HTWNIDELPWDVFHHPSKKKFYYDLVTSLDPELVAAIQPHADAVSPDKPEDVRKIHRRSA 207
Query: 110 LAFLYLYLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLK 169
AFLYL+LS+ Q P + S +P GAGLGSSA+ VCL+AALL + P
Sbjct: 208 SAFLYLFLSLGSSQN--PGAIYTLRSTIPIGAGLGSSASVCVCLSAALLLQIRTLAGPHP 265
Query: 170 DGDCVNRWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGK------ISS 223
D + +E IN+WAF GE HGNPSGVDN VS G A+ + + ++
Sbjct: 266 DQPPDE--AEVQIERINRWAFVGEMCTHGNPSGVDNTVSAGGKAVVFRREDYSKPPTVTP 323
Query: 224 LKRSPALQILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMG 283
L P L +LL +T+ R+T VA V ++P + +L +ID ++L ++ + E+
Sbjct: 324 LLNFPELPLLLVDTRQSRSTAVEVAKVGKLKDEYPVVTDSILEAIDQVTLAAQQKIQEIS 383
Query: 284 EA-PAPEQYLVLEELIDMNQHHLNALGVGHASLDQLCQVTRARGLH-SKLTGAGGGGCGI 341
+ L LI +N L +LGV H L+++ ++ + +KLTGAGGGGC I
Sbjct: 384 TNGISYRTLEDLGTLIRINHGFLVSLGVSHPRLERIRELVDYADIGWTKLTGAGGGGCAI 443
Query: 342 TLLKPGLEQPEVEATKQALTSCGFDCLETSIGAPGVSIHSATSL 385
TLL+P +++ V ++ L++ GF ET++G G+ + L
Sbjct: 444 TLLRPDIKEEAVRELEEKLSAEGFVKYETTLGGDGIGVLWPAVL 487
>ref|XP_790690.1| PREDICTED: similar to Mevalonate kinase (MK) [Strongylocentrotus
purpuratus]
ref|XP_001200159.1| PREDICTED: similar to Mevalonate kinase (MK) [Strongylocentrotus
purpuratus]
Length = 413
Score = 398 bits (1024), Expect = e-109, Method: Composition-based stats.
Identities = 177/383 (46%), Positives = 244/383 (63%), Gaps = 6/383 (1%)
Query: 5 VLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKRAWDV 64
+ +SAPGK+ILHGEHAVVHGK ALA LNLR++L L+ +G++ L+LP+I ++R+WDV
Sbjct: 15 SIFISAPGKIILHGEHAVVHGKTALAAGLNLRSYLCLKEKDSGRLHLNLPDIDLERSWDV 74
Query: 65 ARLQSLDTSFLEQGD-VTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSICRKQ 123
LQ L P+ E +++L+ G D T+RLAV+AFLYLYL I +
Sbjct: 75 LELQEQFRDLLNSDVMEVKPSVEIMQRLRLFLGY-SDTETTKRLAVMAFLYLYLCIAGRN 133
Query: 124 RALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKEDLE 183
P LD +V S LPPGAGLGSSAA+SVCLAA LLT + I PL D W++ED+E
Sbjct: 134 GKFPILDTLVSSALPPGAGLGSSAAFSVCLAAGLLTWAKAI-IPLSLSDNTLDWSREDME 192
Query: 184 LINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVPRNT 243
LIN WA++GER+IHGNPSG+DN++S GGA+ Y Q I+ L+ P L ILL NT V R+T
Sbjct: 193 LINTWAYEGERVIHGNPSGIDNSISVHGGAIEYRQKVITPLENMPELSILLVNTCVARST 252
Query: 244 RALVAGVRNRLLKFPEIVAPLLTSIDAISLECE---RVLGEMGEAPAPEQYLVLEELIDM 300
+ LVAGV+ R K+P++ P+L SI+ IS EC+ + L + L EL+D+
Sbjct: 253 KELVAGVQRRHDKYPKVYGPILDSIEEISQECKRTLQALKTGESLDKDGAFKSLGELVDI 312
Query: 301 NQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL 360
NQ L +GV H +++ + + A +H+KLTGAGGGGC LL P + + V+A + L
Sbjct: 313 NQQLLYVIGVSHPAINNIVRSAAAYKIHAKLTGAGGGGCVFALLPPDIPKDSVKALQADL 372
Query: 361 TSCGFDCLETSIGAPGVSIHSAT 383
++ TS+GA GV +H +
Sbjct: 373 FRHNYESWITSLGAHGVMMHRSK 395
>ref|XP_001559870.1| hypothetical protein BC1G_01429 [Botryotinia fuckeliana B05.10]
gb|EDN27159.1| hypothetical protein BC1G_01429 [Botryotinia fuckeliana B05.10]
Length = 498
Score = 398 bits (1024), Expect = e-109, Method: Composition-based stats.
Identities = 139/398 (34%), Positives = 211/398 (53%), Gaps = 23/398 (5%)
Query: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGK--VDLSLPNIGI 58
M+ +VSAPGKVI+ GEHAVVHGK A+A +++LR++L + S K + L P+I +
Sbjct: 50 MMPP-FMVSAPGKVIVFGEHAVVHGKPAIAAAISLRSYLLVTSLSKSKRTISLRFPDINL 108
Query: 59 KRAWDVARLQSLDTSFL-----EQGDVTTPTSEQVEKLKEVAG--LPDDC---AVTERLA 108
W++ L S +VT+ E V +K PD+ + +
Sbjct: 109 SHTWNIDDLPWSTFSHPSKKKHYYDEVTSLDPELVAAMKPHLENISPDESPAIRKIHQSS 168
Query: 109 VLAFLYLYLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPL 168
+FLY++LS+ ++ P + S +P GAGLGSSA+ SVCL++ALL + P
Sbjct: 169 ASSFLYIFLSLGS--QSFPGCLYTLRSTIPIGAGLGSSASISVCLSSALLLQIRTLSGPH 226
Query: 169 KDGDCVNRWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGK----ISSL 224
D + LE IN+WAF GE IHGNPSGVDN VST G A+ Y + + L
Sbjct: 227 PDQP--SNEASLQLERINRWAFVGEMCIHGNPSGVDNTVSTQGKAVIYQKSPDGPTVKPL 284
Query: 225 KRSPALQILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMG- 283
+ P L +LL +T+ ++T VA V K P IV +L +ID + ++ +
Sbjct: 285 RNFPELPLLLVDTQQAKSTAHEVAKVDLLKQKHPAIVDSILNAIDMVGQSAAVMISDPEY 344
Query: 284 EAPAPEQYLVLEELIDMNQHHLNALGVGHASLDQLCQVTRARGLH-SKLTGAGGGGCGIT 342
++ + L +L+ +N L +LGV H L+++ ++ G+ +KLTGAGGGGC IT
Sbjct: 345 DSEDLKCVEDLGKLMTVNHGLLVSLGVSHPRLERIRELVDHEGIGWTKLTGAGGGGCSIT 404
Query: 343 LLKPGLEQPEVEATKQALTSCGFDCLETSIGAPGVSIH 380
LLKPG + ++ L + G+ ET++G GV +
Sbjct: 405 LLKPGTTHDRMTRLEETLETEGYKKFETTLGCDGVGVL 442
>ref|XP_460851.1| hypothetical protein DEHA0F12188g [Debaryomyces hansenii CBS767]
emb|CAG89196.1| unnamed protein product [Debaryomyces hansenii CBS767]
Length = 433
Score = 395 bits (1015), Expect = e-108, Method: Composition-based stats.
Identities = 133/402 (33%), Positives = 223/402 (55%), Gaps = 18/402 (4%)
Query: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSN-GKVDLSLPNIGIK 59
M LVSAPGKVI++GEH+ V+GK A+A +L+LR +L + P + + L P+IG+
Sbjct: 1 MSVSPFLVSAPGKVIIYGEHSAVYGKPAIAAALSLRAYLLVTPCEDVNDIRLDFPDIGLS 60
Query: 60 RAWDVARLQSLDTSFL--EQGDVTTPTSEQVEKLKEVAG--LPDDCAVTERLAVLAFLYL 115
+W+ + D + + T E V ++ ++ L D + A L FLYL
Sbjct: 61 HSWNKENIPWEDIRKFVTFKDEKPVVTEELVPEIVDLLSTVLADVESKLHYTACLCFLYL 120
Query: 116 YLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPN-PLKDGDCV 174
Y ++ + +P + +V S LP GAGLGSSA +VCLA+AL + + + + V
Sbjct: 121 YANL--SNKDVPGMRFIVKSTLPIGAGLGSSACTAVCLASALARLGKHVSAACHTSTEKV 178
Query: 175 NRWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKI-------SSLKRS 227
+ DL+ I+ W+ GE+ HGNPSG+DNAV+T+GGA+ + + I ++++
Sbjct: 179 YKKENSDLDFIDSWSLMGEKCFHGNPSGIDNAVATYGGAVMFQRTTIPSKPSVRTTMRNF 238
Query: 228 PALQILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPA 287
P ++++L NTKVPR+T ALV V +P+ +L +++ + E +++ + +
Sbjct: 239 PPIKLILINTKVPRSTAALVGNVAQVNRTYPKCAGSILDAMEHLVFEAYQIM--IRPSFG 296
Query: 288 PEQYLVLEELIDMNQHHLNALGVGHASLDQLCQVTRARGLH-SKLTGAGGGGCGITLLKP 346
E+ L EL+++N L ALGV H +L+++ + G+ +KLTGAGGGGC I+L+
Sbjct: 297 KEEKDQLRELVNINHGLLVALGVSHPALEKIKIIGDTHGIGSTKLTGAGGGGCAISLVHD 356
Query: 347 GLEQPEVEATKQALTSCGFDCLETSIGAPGVSIHSATSLDSR 388
+E+ ++ + + G++ ETS+G GV S +D
Sbjct: 357 DVEEEVIQKAIKEFENEGYETFETSLGGKGVGSLSLEDVDKD 398
>ref|XP_723495.1| mevalonate kinase [Candida albicans SC5314]
ref|XP_723305.1| mevalonate kinase [Candida albicans SC5314]
gb|EAL04601.1| hypothetical protein CaO19.12272 [Candida albicans SC5314]
gb|EAL04797.1| hypothetical protein CaO19.4809 [Candida albicans SC5314]
Length = 431
Score = 395 bits (1014), Expect = e-108, Method: Composition-based stats.
Identities = 145/404 (35%), Positives = 222/404 (54%), Gaps = 23/404 (5%)
Query: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNG-KVDLSLPNIGIK 59
M +V APGKVI+ GEHA V+GK A+A +L+LR +L + P S+ + L P+I +
Sbjct: 1 MSQLPFIVGAPGKVIIFGEHAAVYGKPAIAAALSLRCYLLVSPSSDSNTIRLQFPDIKLD 60
Query: 60 RAWDVARLQSLDTSFLEQGD-------VTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAF 112
+W++ L + D + E V+KL D A F
Sbjct: 61 HSWNIKDLPWEEIKPYLTYDSANKPQIPSELVPEIVDKLSSFLNGFD--NKMHYYACFCF 118
Query: 113 LYLYLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNP-LKDG 171
LYL +++C + + ++ +V S LP GAGLGSSA+ SVCL++AL + I P L +
Sbjct: 119 LYLLMNLCDSK--VSGMNFIVRSTLPIGAGLGSSASTSVCLSSALALMGGWINKPSLHEN 176
Query: 172 DCVNRWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGK-------ISSL 224
D ++ DLE I+KW+ GE+ HGNPSG+DNAV+T+GGA+ + + +++
Sbjct: 177 DKLDTADIPDLEFIDKWSLIGEKCFHGNPSGIDNAVATFGGAVMFQRTSTPEQPSIRTNM 236
Query: 225 KRSPALQILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGE 284
+ PA+++LLTNTKVP++T LVAGV +F I +LT+I+ +S E +V+ M
Sbjct: 237 RNFPAIKLLLTNTKVPKSTADLVAGVGRLNAEFNSISTSILTAIEHLSQEAYKVM--MNP 294
Query: 285 APAPEQYLVLEELIDMNQHHLNALGVGHASLDQLCQVTRARGLHS-KLTGAGGGGCGITL 343
E+ VL +L+++N L ALGV H +L+ + + + + KLTGAGGGGC ITL
Sbjct: 295 MFGKEETNVLRKLVNINHGLLVALGVSHPALETVKIIGDKHRIGATKLTGAGGGGCAITL 354
Query: 344 LKPGLEQPEVEATKQALTSCGFDCLETSIGAPGVSIHSATSLDS 387
+ +E+ + + G++ ETS+G GV I LD
Sbjct: 355 VNDDVEESVIHNAIKEFEDSGYESFETSLGGKGVGILFHEDLDD 398
>ref|XP_001401587.1| hypothetical protein An04g02190 [Aspergillus niger]
emb|CAL00706.1| unnamed protein product [Aspergillus niger]
Length = 448
Score = 394 bits (1012), Expect = e-108, Method: Composition-based stats.
Identities = 130/404 (32%), Positives = 202/404 (50%), Gaps = 24/404 (5%)
Query: 2 LSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNG--KVDLSLPNIGIK 59
++ +VSAPGKVI+ GEHAVVHGK A+A +++LR++ + S + L+L ++
Sbjct: 1 MAPPFMVSAPGKVIVFGEHAVVHGKAAMAAAISLRSYFLVTTLSKSQRTITLNLRDMDFN 60
Query: 60 RAWDVARLQS-----LDTSFLEQGDVTTPTSEQVEKLKEVAG-----LPDDCAVTERLAV 109
W++ L VT+ E + LK P++ + +
Sbjct: 61 HTWNIDDLPWDFFKQPSKKKYYYDLVTSLDEELYDSLKPCVEDISPKAPEEIRKKHKGSA 120
Query: 110 LAFLYLYLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLK 169
LAFLYL+ S+ Q P + S +P GAGLGSSA+ C +AALL + P
Sbjct: 121 LAFLYLFCSLGSPQH--PGAIYTLRSTIPMGAGLGSSASVCTCFSAALLLQIRTLAGPHD 178
Query: 170 DGDCVNRWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQ------GKISS 223
D + +E IN+WAF GE IHGNPSGVDN VST G A+ + + K+
Sbjct: 179 DQPPDE--AELQIERINRWAFVGELCIHGNPSGVDNTVSTGGKAVIFRREDYSKPPKVIP 236
Query: 224 LKRSPALQILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVL-GEM 282
L P L +LL +T+ R+T VA V + P + +L +ID +++ + + G
Sbjct: 237 LPNFPELPLLLVDTRQSRSTAVEVAKVGKLKKEHPLVTESILDAIDKVTVSAQSAIQGVE 296
Query: 283 GEAPAPEQYLVLEELIDMNQHHLNALGVGHASLDQLCQVTRARGLH-SKLTGAGGGGCGI 341
G++ E + L+ +N L +LGV H L+++ ++ + +KLTGAGGGGC I
Sbjct: 297 GDSIDKETLEHIGTLVRVNHGFLVSLGVSHPRLERIRELVDFANIGWTKLTGAGGGGCAI 356
Query: 342 TLLKPGLEQPEVEATKQALTSCGFDCLETSIGAPGVSIHSATSL 385
TLL+P + ++ L + F ET++G G+ + L
Sbjct: 357 TLLRPDASVDALRELERKLAAENFSKYETTLGGDGIGVLWPAVL 400
>ref|XP_370449.1| hypothetical protein MGG_06946 [Magnaporthe grisea 70-15]
gb|EDJ98120.1| hypothetical protein MGG_06946 [Magnaporthe grisea 70-15]
Length = 494
Score = 393 bits (1009), Expect = e-107, Method: Composition-based stats.
Identities = 128/387 (33%), Positives = 199/387 (51%), Gaps = 24/387 (6%)
Query: 2 LSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGK--VDLSLPNIGIK 59
+ +VSAPGKVI+ GEH+VV+GK A+A ++NLR++L + S K + L P+I +
Sbjct: 43 MMPAFMVSAPGKVIVFGEHSVVYGKKAVAAAINLRSYLLVTALSKSKRTITLRFPDIDLI 102
Query: 60 RAWDVARLQSL-----DTSFLEQGDVTTPTSEQVEKLKE-----VAGLPDDCAVTERLAV 109
W++ L VT+ + ++ ++ + PD A
Sbjct: 103 HTWNIDDLPWSTFSQPSKKKYYYDLVTSLDPDLMDAIQPHLEPVSSDAPDAQRKVHMSAA 162
Query: 110 LAFLYLYLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLK 169
AFLYL++S+ A P + S +P GAGLGSSA+ S CL+AALL + P
Sbjct: 163 AAFLYLFMSLGS--HAFPGGIYTLRSTIPIGAGLGSSASISACLSAALLLQIRTLSGPHP 220
Query: 170 DGDCVNRWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGK------ISS 223
D + +E IN+WAF E IHGNPSGVDN VST G A+ + + ++
Sbjct: 221 DQPPDE--ARVQVERINRWAFVAEMCIHGNPSGVDNTVSTQGKAVVFQRLDYARPPVVTP 278
Query: 224 LKRSPALQILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMG 283
+ P L +L+ +TK ++T+ V V P+IV +L S+D ++ VL +
Sbjct: 279 MWDFPELPLLVVDTKQAKSTKYEVEKVAKLRETHPKIVNSILDSMDKLTQAATDVLTDED 338
Query: 284 -EAPAPEQYLVLEELIDMNQHHLNALGVGHASLDQLCQVTRARGLH-SKLTGAGGGGCGI 341
+ E + EL+ MN L +LGV H L+++ ++ G+ +KLTGAGGGGC I
Sbjct: 339 FDNEDVESLQKVGELMGMNHGLLVSLGVSHPRLERVRELVDHEGIGWTKLTGAGGGGCSI 398
Query: 342 TLLKPGLEQPEVEATKQALTSCGFDCL 368
TL++P + + ++E K+ L G+
Sbjct: 399 TLMRPDVPREKLERLKERLDHEGYLKF 425
>ref|XP_001527900.1| hypothetical protein LELG_00420 [Lodderomyces elongisporus NRRL
YB-4239]
gb|EDK42242.1| hypothetical protein LELG_00420 [Lodderomyces elongisporus NRRL
YB-4239]
Length = 439
Score = 391 bits (1005), Expect = e-107, Method: Composition-based stats.
Identities = 146/393 (37%), Positives = 219/393 (55%), Gaps = 24/393 (6%)
Query: 6 LLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPH--SNGKVDLSLPNIGIKRAWD 63
+VSAPGKVI+ GEHA V+GK A+A +L+LR FL + P + V L P+IG+ +WD
Sbjct: 11 FVVSAPGKVIIFGEHAAVYGKPAIAAALSLRCFLLVTPSTGDSNMVRLKFPDIGLDHSWD 70
Query: 64 VARLQSLDT-------SFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLY 116
++ + S + E V+ L + DD +A FLYLY
Sbjct: 71 ISSIPWETIKAKVKADSNGKPQPPAELDPEIVDSLSPLLRNLDDN--VHYIACFCFLYLY 128
Query: 117 LSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNP-LKDGDCVN 175
++C + L VV S LP GAGLGSSA+ +VCL+AAL + I +P L + D V
Sbjct: 129 TNLCS--QDLQGYTFVVRSTLPIGAGLGSSASTAVCLSAALSKLGNWIKDPKLSNHDHVL 186
Query: 176 RWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQ-------GKISSLKRSP 228
+L+ I+ W+ GE+ HGNPSG+DNAV+T GGA++Y + SS++ P
Sbjct: 187 ESEIPELDFIDNWSLIGEKCFHGNPSGIDNAVATHGGAVKYQRILNSTKSSLRSSIRDFP 246
Query: 229 ALQILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAP 288
+++LLTNTKVP++T LVAGV +FP+I P+L +++ IS + V+
Sbjct: 247 PIKLLLTNTKVPKSTAKLVAGVGELTKEFPDITNPILNAVEFISEQAYEVMHLPQ--FGK 304
Query: 289 EQYLVLEELIDMNQHHLNALGVGHASLDQLCQVTRARGLHS-KLTGAGGGGCGITLLKPG 347
++ L +L++MN L ALGV H +L+ + ++ L + KLTGAGGGGC ITL+
Sbjct: 305 QETATLRKLVNMNHGLLVALGVSHPALETVKIISDKYNLGATKLTGAGGGGCAITLVDES 364
Query: 348 LEQPEVEATKQALTSCGFDCLETSIGAPGVSIH 380
+++ + + + GF+ ETS+G GV +
Sbjct: 365 IDKSVIHNAMKEYENEGFESFETSLGGKGVGML 397
>ref|XP_001382664.2| mevalonate kinase [Pichia stipitis CBS 6054]
gb|ABN64635.2| mevalonate kinase [Pichia stipitis CBS 6054]
Length = 432
Score = 386 bits (992), Expect = e-105, Method: Composition-based stats.
Identities = 141/405 (34%), Positives = 224/405 (55%), Gaps = 22/405 (5%)
Query: 2 LSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSN-GKVDLSLPNIGIKR 60
+S VSAPGKVI+ GEH+ V+GK A+A +L+LR +L + P + ++LS P+I +
Sbjct: 1 MSTPFFVSAPGKVIIFGEHSAVYGKPAIAAALSLRAYLLVTPSQDPDTINLSFPDINLTH 60
Query: 61 AWDVARLQSLD-TSFLEQGDVTTPTSEQ-----VEKLKEVAGLPDDCAVTERLAVLAFLY 114
+W+ + + D TSE+ V++L V L D + A L FLY
Sbjct: 61 SWNKNDIPWDSIVKHINLVDNLPQTSEELVPEIVDQLGSV--LADLNSSLHYTACLCFLY 118
Query: 115 LYLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEI-PNPLKDGDC 173
LY +C ++ L + + S LP GAGLGSSA+ +VCLA+AL + + D
Sbjct: 119 LYTHLCNQE--LAGMSFCIRSTLPIGAGLGSSASTAVCLASALAILGNRVTSASFLQTDK 176
Query: 174 VNRWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQ-------GKISSLKR 226
+ + DL+ I+ W+ GE+ HGNPSG+DNAV+T GGA+ + + +S++
Sbjct: 177 ILKKENNDLDFIDSWSLMGEKCFHGNPSGIDNAVATHGGAVMFQRMNNPAQPSVRTSMRN 236
Query: 227 SPALQILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAP 286
PA+++LLTNTKVPR+T LV GV +++P+ +L +++ +S +++ +
Sbjct: 237 FPAIKLLLTNTKVPRSTADLVGGVGKLNVEYPKTSNSILEAMEHLSNTAYQIM--VRPFF 294
Query: 287 APEQYLVLEELIDMNQHHLNALGVGHASLDQLCQVTRARGLH-SKLTGAGGGGCGITLLK 345
E+ L EL+++N L ALGV H SL+++ +T L +KLTGAGGGGC ITL+
Sbjct: 295 GAEERKKLRELVNINHGLLVALGVSHPSLEKVKIITDTSKLGSTKLTGAGGGGCAITLVD 354
Query: 346 PGLEQPEVEATKQALTSCGFDCLETSIGAPGVSIHSATSLDSRVQ 390
+ + ++ L G++C ETS+G GV S + ++
Sbjct: 355 EDVSEADIAQGIAELEKEGYECFETSLGGKGVGSLSFEDVPQELR 399
>gb|EEH37797.1| mevalonate kinase [Paracoccidioides brasiliensis Pb01]
Length = 545
Score = 372 bits (955), Expect = e-101, Method: Composition-based stats.
Identities = 128/405 (31%), Positives = 194/405 (47%), Gaps = 40/405 (9%)
Query: 2 LSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNG--KVDLSLPNIGIK 59
++ +VSAPGKVI+ GEHAVVHGK A+A +++LR++L + S + L+ +I +
Sbjct: 109 MAPAFMVSAPGKVIVFGEHAVVHGKRAMAAAISLRSYLLVTTLSKSQRTITLNFRDIELD 168
Query: 60 RAWDVARLQSL-----DTSFLEQGDVTTPTSEQVEKLKE-----VAGLPDDCAVTERLAV 109
WD+ L VT+ E +E ++ G PD+ R +
Sbjct: 169 HTWDIDSLPWALFCQPSKKKFYYDSVTSLDPELLEAIQPHIADISIGKPDEVQKIHRSSA 228
Query: 110 LAFLYLYLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLK 169
AFLYL+LS+ + + S +P GAGLGSSA+ +VCL+AALL + P
Sbjct: 229 TAFLYLFLSLSSP--GSHAAIYTLRSTIPIGAGLGSSASIAVCLSAALLLQIRILAGPHH 286
Query: 170 DGDCVNRWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGK------ISS 223
D + +E IN+WAF GE IHGNPSGVDN VS G A+ + +G ++
Sbjct: 287 DQPP--EEAEVQIERINRWAFVGEMCIHGNPSGVDNTVSAGGKAVIFRRGDYSKPPSVTP 344
Query: 224 LKRSPALQILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMG 283
+ P L +LL + P P + L +ID ++ +
Sbjct: 345 ILDFPELPLLLAGSAKP----------------TPAVAESTLAAIDQVTESANNFIQSGR 388
Query: 284 -EAPAPEQYLVLEELIDMNQHHLNALGVGHASLDQLCQVTRARGLH-SKLTGAGGGGCGI 341
+ + E EL +N L +LGV H L+++ ++ G+ +KLTGAGGGGC I
Sbjct: 389 FDKDSNEDIDHFGELFRINHGLLVSLGVSHPRLERIRELVDHAGIGWTKLTGAGGGGCAI 448
Query: 342 TLLKPGLEQPEVEATKQALTSCGFDCLETSIGAPGVSIHSATSLD 386
LL+ Q + +Q L GF+ ET++G G+ + L
Sbjct: 449 VLLRANTNQAVLHHLEQNLDDEGFERYETTLGGDGIGVLWPAVLK 493
>ref|XP_001628178.1| predicted protein [Nematostella vectensis]
gb|EDO36115.1| predicted protein [Nematostella vectensis]
Length = 415
Score = 360 bits (925), Expect = 8e-98, Method: Composition-based stats.
Identities = 162/409 (39%), Positives = 235/409 (57%), Gaps = 29/409 (7%)
Query: 6 LLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSN-GKVDLSLPNIGIKRAWDV 64
++VSAPGK+ILHGEHAVV+GK A+AVS+ LRT + LQ H N KV L L ++ WD+
Sbjct: 6 VVVSAPGKIILHGEHAVVYGKAAIAVSIGLRTTVVLQRHKNESKVSLLLKDLDYILTWDL 65
Query: 65 ARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTE----RLAVLAFLYLYLSIC 120
+Q + + + Q T E L + L D E + A FL+L S
Sbjct: 66 TDIQKILVA-VPQVSRTDTVLPSDEMLSLIDKLIDSSKFVEVEGVKDAARVFLFLMTSTL 124
Query: 121 RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPL------------ 168
R + LP++++ V + LP GAGLGSSAAYS+ LAAA+L + IP P
Sbjct: 125 RDRDRLPAIEVEVKTALPLGAGLGSSAAYSISLAAAMLLSMQTIPLPKYVKKTPESETTA 184
Query: 169 --KDGDCVNRWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKR 226
D + E L L+ +WAF+ E+++HG PSG+DN+++T+GGAL + G+I+ L+
Sbjct: 185 KDTDSYQYDDIETESLRLVCQWAFEAEKIMHGQPSGIDNSIATYGGALLFQNGEITHLES 244
Query: 227 SPALQILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAP 286
P L ILL +T++PR+TR +VAGVR+R ++FP + L ++D I EC ++ ++
Sbjct: 245 MPLLSILLIDTQIPRSTRVMVAGVRDRYIEFPTVYMSLFEAVDGICHECIKIFSKIHNLK 304
Query: 287 APEQ--------YLVLEELIDMNQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGG 338
+ Y LE L+D+NQ L+ GV H SLD LC +T GLH+KLTGAGGGG
Sbjct: 305 NEDVPKSEFVRYYQRLESLVDVNQQLLSLFGVSHPSLDSLCHMTSKYGLHTKLTGAGGGG 364
Query: 339 CGITLLKPGLEQPEVEATKQALTSC-GFDCLETSIGAPGVSIHSATSLD 386
C ITL+ PG ++ +V L + +T +G+ GV +H A +D
Sbjct: 365 CAITLIPPGTDKDKVAELMNKLQKEFKYKVWQTPLGSRGVIVHEAIPVD 413
>gb|AAD45421.1|L77688_1 mevalonate kinase [Arabidopsis thaliana]
Length = 376
Score = 356 bits (914), Expect = 2e-96, Method: Composition-based stats.
Identities = 143/380 (37%), Positives = 220/380 (57%), Gaps = 18/380 (4%)
Query: 8 VSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQ---PHSNGKVDLSLPNIGIKRAWDV 64
APGK+IL GEHAVVHG A+A +++L T++ L+ P +N ++ L L +I ++ +W +
Sbjct: 5 ARAPGKIILAGEHAVVHGSTAVAAAIDLYTYVTLRFPLPSNNDRLTLQLKDISLEFSWSL 64
Query: 65 ARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTE-----RLAVLAFLYLYLSI 119
AR++ +TP S E LK +A L ++ + + + FL+LY I
Sbjct: 65 ARIKEAIPYDSSTLCRSTPASCSEETLKSIAVLVEEQNLPKEKMWLSSGISTFLWLYTRI 124
Query: 120 CRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTK 179
+V+ SELP G+GLGSSAA V L AALL + G+ + +
Sbjct: 125 I----GFNPATVVINSELPYGSGLGSSAALCVALTAALLASS---ISEKTRGNGWSSLDE 177
Query: 180 EDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKV 239
+LEL+NKWAF+GE++IHG PSG+DN VS +G +++ G+I+ L+ + L++L+TNT+V
Sbjct: 178 TNLELLNKWAFEGEKIIHGKPSGIDNTVSAYGNMIKFCSGEITRLQSNMPLRMLITNTRV 237
Query: 240 PRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELID 299
RNT+ALV+GV R ++ P+ + + ++D+IS E ++ E E+ ++EL++
Sbjct: 238 GRNTKALVSGVSQRAVRHPDAMKSVFNAVDSISKELAAIIQSKDETSVTEKEERIKELME 297
Query: 300 MNQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQA 359
MNQ L ++GV H+S++ + T L SKLTGAGGGGC +TLL G V+ +
Sbjct: 298 MNQGLLLSMGVSHSSIEAVILTTVKHKLVSKLTGAGGGGCVLTLLPTGT---VVDKVVEE 354
Query: 360 LTSCGFDCLETSIGAPGVSI 379
L S GF C IG G I
Sbjct: 355 LESSGFQCFTALIGGNGAQI 374
>ref|NP_013935.1| Mevalonate kinase, acts in the biosynthesis of isoprenoids and
sterols, including ergosterol, from mevalonate; Erg12p
[Saccharomyces cerevisiae]
sp|P07277|KIME_YEAST Mevalonate kinase (MK) (MvK)
emb|CAA39359.1| mevalonate kinase [Saccharomyces cerevisiae]
emb|CAA29487.1| unnamed protein product [Saccharomyces cerevisiae]
emb|CAA89923.1| Rar1p [Saccharomyces cerevisiae]
Length = 443
Score = 356 bits (913), Expect = 2e-96, Method: Composition-based stats.
Identities = 128/417 (30%), Positives = 217/417 (52%), Gaps = 36/417 (8%)
Query: 2 LSEVLLVSAPGKVILHGEHAVVHGKVALAVSLN-LRTFLRLQPHSN-GKVDLSLPNIGIK 59
+S L SAPGKVI+ GEH+ V+ K A+A S++ LRT+L + S ++L P+I
Sbjct: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFN 60
Query: 60 RAWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVT-----ERLAVLAFLY 114
W + ++ + + +E+ L D A FLY
Sbjct: 61 HKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLY 120
Query: 115 LYLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCV 174
+++ +C + ++ + S LP GAGLGSSA+ SV LA A+ + I + + +
Sbjct: 121 MFVCLCPHAK---NIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLIGS-----NDL 172
Query: 175 NRWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQ---------GKISSLK 225
+ ++ D ++N+WAF GE+ IHG PSG+DNAV+T+G AL + + L
Sbjct: 173 EKLSENDKHIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLD 232
Query: 226 RSPALQILLTNTKVPRNTRALVAGVRNR-LLKFPEIVAPLLTSIDAISLECERVLGEMGE 284
PA+ ++LT T++PR+T+ LVA VR KFPE++ P+L ++ +L+ ++ ++ +
Sbjct: 233 DFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSK 292
Query: 285 ---------APAPEQYLVLEELIDMNQHHLNALGVGHASLDQLCQVTRARGLH-SKLTGA 334
E Y L ELI +N L ++GV H L+ + ++ + +KLTGA
Sbjct: 293 CKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGA 352
Query: 335 GGGGCGITLLKPGLEQPEVEATKQAL-TSCGFDCLETSIGAPGVSIHSATSLDSRVQ 390
GGGGC +TLL+ + Q ++++ K+ L ++ ET +G G + SA +L+ ++
Sbjct: 353 GGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLNKDLK 409
>gb|EDN64144.1| mevalonate kinase [Saccharomyces cerevisiae YJM789]
Length = 443
Score = 354 bits (910), Expect = 5e-96, Method: Composition-based stats.
Identities = 128/415 (30%), Positives = 215/415 (51%), Gaps = 36/415 (8%)
Query: 2 LSEVLLVSAPGKVILHGEHAVVHGKVALAVSLN-LRTFLRLQPHSN-GKVDLSLPNIGIK 59
+S L SAPGKVI+ GEH+ V+ K A+A S++ LRT+L + S ++L P+I
Sbjct: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFN 60
Query: 60 RAWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVT-----ERLAVLAFLY 114
W + ++ + + +E+ L D A FLY
Sbjct: 61 HKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLY 120
Query: 115 LYLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCV 174
+++ +C + ++ + S LP GAGLGSSA+ SV LA A+ + I + + +
Sbjct: 121 MFVCLCPHAK---NIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLIGS-----NDL 172
Query: 175 NRWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQ---------GKISSLK 225
+ ++ D ++N+WAF GE+ IHG PSG+DNAV+T+G AL + + L
Sbjct: 173 EKLSENDKHIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLD 232
Query: 226 RSPALQILLTNTKVPRNTRALVAGVRNR-LLKFPEIVAPLLTSIDAISLECERVLGEMGE 284
PA+ ++LT T++PR+T+ LVA VR KFPE++ P+L ++ +L+ ++ ++ +
Sbjct: 233 DFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSK 292
Query: 285 ---------APAPEQYLVLEELIDMNQHHLNALGVGHASLDQLCQVTRARGLH-SKLTGA 334
E Y L ELI +N L ++GV H L+ + ++ + +KLTGA
Sbjct: 293 CKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGA 352
Query: 335 GGGGCGITLLKPGLEQPEVEATKQAL-TSCGFDCLETSIGAPGVSIHSATSLDSR 388
GGGGC +TLL+ + Q ++++ K+ L ++ ET +G G + SA +L+
Sbjct: 353 GGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLNKD 407
>ref|XP_001483309.1| hypothetical protein PGUG_04038 [Pichia guilliermondii ATCC 6260]
gb|EDK39940.1| hypothetical protein PGUG_04038 [Pichia guilliermondii ATCC 6260]
Length = 423
Score = 354 bits (908), Expect = 8e-96, Method: Composition-based stats.
Identities = 130/388 (33%), Positives = 199/388 (51%), Gaps = 20/388 (5%)
Query: 5 VLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKRAWDV 64
+SAPGKVIL GEHA V+GK ALA +L+LR +L ++ + L P+I + +W +
Sbjct: 3 PFYISAPGKVILFGEHAAVYGKPALAAALSLRAYLLATETNDDSLRLEFPDIQLSHSWKL 62
Query: 65 ARLQS------LDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLS 118
+ L ++ + E + + E G D + L FLYLYL
Sbjct: 63 SELPWENAQAHIERKNGKPVPTDELNPEVINLIGEFLG--DIESTAHYTTCLCFLYLYLH 120
Query: 119 ICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWT 178
+C + S + S LP GAGLGSSA+ +VCL + L + I +P
Sbjct: 121 LCDPL--VASRSFCIRSTLPIGAGLGSSASAAVCLTSTLALLGGHIRSPQYSEKQRVSSE 178
Query: 179 KEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQ-------GKISSLKRSPALQ 231
D E I+ W+ GE+ HGNPSG+DNAV+T GGA+ Y + ++++ P L+
Sbjct: 179 NPDAEFIDSWSLMGEKCFHGNPSGIDNAVATHGGAVMYQRMLAPDMPSVRTAMRNFPPLK 238
Query: 232 ILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQY 291
+LLTNTKVPR+T LV GV + P+ +L ++ ++ + ++ + A E
Sbjct: 239 LLLTNTKVPRSTAELVGGVAKVNTRHPKTAGSILDAVSHLATDAYHIMS--HPSFAAEDR 296
Query: 292 LVLEELIDMNQHHLNALGVGHASLDQLCQVTRARGLHS-KLTGAGGGGCGITLLKPGLEQ 350
L +L+++N L ALGV H +L+++ + + + KLTGAGGGGC ITLL +
Sbjct: 297 ESLRQLVNINHGLLVALGVSHPALEKIKMIGDTNRIGATKLTGAGGGGCAITLLNDEVSH 356
Query: 351 PEVEATKQALTSCGFDCLETSIGAPGVS 378
+E + T GF+ E ++G GV
Sbjct: 357 EVLEKVENEFTQEGFETFEATLGGKGVG 384
>ref|NP_198097.1| MK/MVK; mevalonate kinase [Arabidopsis thaliana]
ref|NP_851084.1| MK/MVK; mevalonate kinase [Arabidopsis thaliana]
sp|P46086|KIME_ARATH Mevalonate kinase (MK)
gb|AAD31719.1|AF141853_1 mevalonate kinase [Arabidopsis thaliana]
emb|CAA54820.1| mevalonate kinase [Arabidopsis thaliana]
gb|AAM13164.1| mevalonate kinase [Arabidopsis thaliana]
gb|AAM60916.1| mevalonate kinase [Arabidopsis thaliana]
gb|AAN72115.1| mevalonate kinase [Arabidopsis thaliana]
Length = 378
Score = 351 bits (901), Expect = 5e-95, Method: Composition-based stats.
Identities = 142/382 (37%), Positives = 219/382 (57%), Gaps = 20/382 (5%)
Query: 8 VSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQ-----PHSNGKVDLSLPNIGIKRAW 62
APGK+IL GEHAVVHG A+A +++L T++ L+ +N ++ L L +I ++ +W
Sbjct: 5 ARAPGKIILAGEHAVVHGSTAVAAAIDLYTYVTLRFPLPSAENNDRLTLQLKDISLEFSW 64
Query: 63 DVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTE-----RLAVLAFLYLYL 117
+AR++ +TP S E LK +A L ++ + + + FL+LY
Sbjct: 65 SLARIKEAIPYDSSTLCRSTPASCSEETLKSIAVLVEEQNLPKEKMWLSSGISTFLWLYT 124
Query: 118 SICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRW 177
I +V+ SELP G+GLGSSAA V L AALL + G+ +
Sbjct: 125 RII----GFNPATVVINSELPYGSGLGSSAALCVALTAALLASS---ISEKTRGNGWSSL 177
Query: 178 TKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNT 237
+ +LEL+NKWAF+GE++IHG PSG+DN VS +G +++ G+I+ L+ + L++L+TNT
Sbjct: 178 DETNLELLNKWAFEGEKIIHGKPSGIDNTVSAYGNMIKFCSGEITRLQSNMPLRMLITNT 237
Query: 238 KVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEEL 297
+V RNT+ALV+GV R ++ P+ + + ++D+IS E ++ E E+ ++EL
Sbjct: 238 RVGRNTKALVSGVSQRAVRHPDAMKSVFNAVDSISKELAAIIQSKDETSVTEKEERIKEL 297
Query: 298 IDMNQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATK 357
++MNQ L ++GV H+S++ + T L SKLTGAGGGGC +TLL G V+
Sbjct: 298 MEMNQGLLLSMGVSHSSIEAVILTTVKHKLVSKLTGAGGGGCVLTLLPTGT---VVDKVV 354
Query: 358 QALTSCGFDCLETSIGAPGVSI 379
+ L S GF C IG G I
Sbjct: 355 EELESSGFQCFTALIGGNGAQI 376
>gb|AAL18925.1|AF429384_1 mevalonate kinase [Hevea brasiliensis]
dbj|BAF98283.1| mevalonate kinase [Hevea brasiliensis]
Length = 386
Score = 349 bits (896), Expect = 2e-94, Method: Composition-based stats.
Identities = 149/382 (39%), Positives = 225/382 (58%), Gaps = 16/382 (4%)
Query: 8 VSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRL---QPHSNGKVDLSLPNIGIKRAWDV 64
APGK+IL GEHAVVHG A+A S+NL T++ L ++ + L L ++ ++ +W +
Sbjct: 5 ARAPGKIILSGEHAVVHGSTAVAASINLYTYVTLSFATAENDDSLKLQLKDLALEFSWPI 64
Query: 65 ARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVL-----AFLYLYLSI 119
R++ ++ L +T TS +E +K ++ L ++ + E L AFL+LY SI
Sbjct: 65 GRIREALSN-LGAPSSSTRTSCSMESIKTISALVEEENIPEAKIALTSGVSAFLWLYTSI 123
Query: 120 CRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTK 179
+ +VV S+LP G+GLGSSAA+ V L+AALL + + K + + +
Sbjct: 124 ----QGFKPATVVVTSDLPLGSGLGSSAAFCVALSAALLAFSDSVNVDTKHLG-WSIFGE 178
Query: 180 EDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKV 239
DLEL+NKWA +GE++IHG PSG+DN VS +G +++ G ++ +K + L++L+TNT+V
Sbjct: 179 SDLELLNKWALEGEKIIHGKPSGIDNTVSAYGNMIKFKSGNLTRIKSNMPLKMLVTNTRV 238
Query: 240 PRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGE--MGEAPAPEQYLVLEEL 297
RNT+ALVAGV R L+ P ++ + ++D+IS E ++ + E+ LEEL
Sbjct: 239 GRNTKALVAGVSERTLRHPNAMSFVFNAVDSISNELANIIQSPAPDDVSITEKEEKLEEL 298
Query: 298 IDMNQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATK 357
++MNQ L +GV HAS++ + + T L SKLTGAGGGGC +TLL L V+
Sbjct: 299 MEMNQGLLQCMGVSHASIETVLRTTLKYKLASKLTGAGGGGCVLTLLPTLLSGTVVDKAI 358
Query: 358 QALTSCGFDCLETSIGAPGVSI 379
L SCGF CL IG GV
Sbjct: 359 AELESCGFQCLIAGIGGNGVEF 380
>gb|AAX46707.1| mevalonate kinase [Bos taurus]
Length = 363
Score = 348 bits (893), Expect = 5e-94, Method: Composition-based stats.
Identities = 207/253 (81%), Positives = 223/253 (88%)
Query: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 60
MLSEVLLVSAPGKVILHGEHAVVHGKVALAV+LNLRTFLRLQPHSNG+V L+LPNIG++R
Sbjct: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVALNLRTFLRLQPHSNGRVGLNLPNIGVRR 60
Query: 61 AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC 120
AWDVA LQ LDTSFL GD T++ VEKLKEVAG P DC E LAVLAFLYLYLSIC
Sbjct: 61 AWDVASLQLLDTSFLGHGDSAALTAKHVEKLKEVAGFPKDCVDPEHLAVLAFLYLYLSIC 120
Query: 121 RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE 180
+ QR LPSLDI VWSELP GAGLGSSAAYSVCLAAALLT CEEIPNPLKDG+ RWT+E
Sbjct: 121 QSQRVLPSLDITVWSELPTGAGLGSSAAYSVCLAAALLTACEEIPNPLKDGEAAGRWTEE 180
Query: 181 DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP 240
+LELINKWAFQGER+IHGNPSGVDNAVSTWGGALRY QGKISSLKR P L+ILL NTKVP
Sbjct: 181 NLELINKWAFQGERVIHGNPSGVDNAVSTWGGALRYQQGKISSLKRPPVLKILLINTKVP 240
Query: 241 RNTRALVAGVRNR 253
R+T+ LVA VR+R
Sbjct: 241 RSTKVLVANVRSR 253
Searching..................................................done
Results from round 3
Score E
Sequences producing significant alignments: (bits) Value
Sequences used in model and found again:
emb|CAA53059.1| unnamed protein product [Hepatitis B virus] 438 e-121
ref|XP_001105759.1| PREDICTED: mevalonate kinase isoform 2 ... 428 e-118
dbj|BAD92959.1| mevalonate kinase variant [Homo sapiens] 425 e-117
ref|NP_000422.1| mevalonate kinase [Homo sapiens] >gi|16700... 424 e-117
gb|AAQ02416.1| mevalonate kinase [synthetic construct] 424 e-117
ref|XP_001496887.1| PREDICTED: similar to mevalonate kinase... 402 e-110
ref|XP_543435.2| PREDICTED: similar to Mevalonate kinase (M... 402 e-110
ref|NP_001015528.1| mevalonate kinase [Bos taurus] >gi|7506... 400 e-110
gb|AAX08684.1| mevalonate kinase [Bos taurus] 400 e-109
ref|XP_001364115.1| PREDICTED: similar to mevalonate kinase... 390 e-107
gb|AAX46713.1| mevalonate kinase [Bos taurus] 389 e-106
ref|NP_076045.1| mevalonate kinase [Mus musculus] >gi|89281... 388 e-106
ref|NP_112325.1| mevalonate kinase [Rattus norvegicus] >gi|... 385 e-105
dbj|BAE28997.1| unnamed protein product [Mus musculus] 380 e-104
ref|XP_001911734.1| unnamed protein product [Podospora anse... 367 e-100
ref|XP_001229023.1| hypothetical protein CHGG_02507 [Chaeto... 364 6e-99
ref|XP_386088.1| hypothetical protein FG05912.1 [Gibberella... 362 3e-98
ref|XP_961360.1| hypothetical protein NCU03633 [Neurospora ... 359 2e-97
ref|XP_001593159.1| hypothetical protein SS1G_06081 [Sclero... 358 4e-97
ref|XP_001214601.1| conserved hypothetical protein [Aspergi... 355 3e-96
ref|XP_661473.1| hypothetical protein AN3869.2 [Aspergillus... 355 3e-96
ref|XP_001821298.1| hypothetical protein [Aspergillus oryza... 355 4e-96
gb|EEH48028.1| mevalonate kinase [Paracoccidioides brasilie... 354 6e-96
ref|XP_752047.1| mevalonate kinase [Aspergillus fumigatus A... 353 1e-95
ref|XP_001267243.1| mevalonate kinase [Neosartorya fischeri... 353 1e-95
gb|EDP50156.1| mevalonate kinase [Aspergillus fumigatus A1163] 352 2e-95
ref|XP_001271672.1| mevalonate kinase [Aspergillus clavatus... 352 3e-95
ref|XP_001559870.1| hypothetical protein BC1G_01429 [Botryo... 351 6e-95
ref|XP_001241830.1| hypothetical protein CIMG_05726 [Coccid... 350 2e-94
ref|XP_001105689.1| PREDICTED: mevalonate kinase isoform 1 ... 349 3e-94
ref|XP_460851.1| hypothetical protein DEHA0F12188g [Debaryo... 346 2e-93
ref|XP_001401587.1| hypothetical protein An04g02190 [Asperg... 346 2e-93
ref|XP_790690.1| PREDICTED: similar to Mevalonate kinase (M... 345 3e-93
ref|XP_723495.1| mevalonate kinase [Candida albicans SC5314... 344 8e-93
ref|XP_001527900.1| hypothetical protein LELG_00420 [Lodder... 339 3e-91
emb|CAM15186.1| novel protein similar to vertebrate mevalon... 338 3e-91
ref|NP_001007350.1| hypothetical protein LOC492477 [Danio r... 338 4e-91
ref|XP_001382664.2| mevalonate kinase [Pichia stipitis CBS ... 335 4e-90
ref|XP_918559.1| PREDICTED: similar to mevalonate kinase [M... 332 4e-89
ref|XP_370449.1| hypothetical protein MGG_06946 [Magnaporth... 331 7e-89
gb|EEH37797.1| mevalonate kinase [Paracoccidioides brasilie... 327 9e-88
emb|CAG08527.1| unnamed protein product [Tetraodon nigrovir... 326 3e-87
gb|AAD45421.1|L77688_1 mevalonate kinase [Arabidopsis thali... 317 1e-84
ref|NP_198097.1| MK/MVK; mevalonate kinase [Arabidopsis tha... 312 3e-83
ref|XP_001483309.1| hypothetical protein PGUG_04038 [Pichia... 312 4e-83
ref|XP_001628178.1| predicted protein [Nematostella vectens... 308 7e-82
gb|ABK95983.1| unknown [Populus trichocarpa] 305 4e-81
emb|CAO17636.1| unnamed protein product [Vitis vinifera] 302 3e-80
ref|XP_567851.1| cystathionine beta-lyase [Cryptococcus neo... 300 1e-79
gb|AAL18925.1|AF429384_1 mevalonate kinase [Hevea brasilien... 300 1e-79
ref|XP_567850.1| cystathionine beta-lyase [Cryptococcus neo... 299 3e-79
ref|NP_013935.1| Mevalonate kinase, acts in the biosynthesi... 298 4e-79
gb|EDN64144.1| mevalonate kinase [Saccharomyces cerevisiae ... 296 2e-78
ref|NP_001064360.1| Os10g0329300 [Oryza sativa (japonica cu... 296 3e-78
ref|XP_001779131.1| predicted protein [Physcomitrella paten... 295 4e-78
ref|XP_001846214.1| mevalonate kinase [Culex pipiens quinqu... 291 6e-77
ref|NP_001093299.1| mevalonate kinase [Bombyx mori] >gi|146... 291 1e-76
ref|XP_001836355.1| hypothetical protein CC1G_06440 [Coprin... 290 2e-76
gb|EDU45497.1| mevalonate kinase [Pyrenophora tritici-repen... 289 2e-76
ref|XP_001657825.1| mevalonate kinase [Aedes aegypti] >gi|1... 288 6e-76
ref|XP_001540400.1| conserved hypothetical protein [Ajellom... 288 8e-76
ref|NP_985191.1| AER335Wp [Ashbya gossypii ATCC 10895] >gi|... 286 3e-75
ref|NP_592837.1| mevalonate kinase Erg12 (predicted) [Schiz... 286 3e-75
ref|XP_001644409.1| hypothetical protein Kpol_1064p33 [Vand... 283 2e-74
ref|YP_183887.1| mevalonate kinase [Thermococcus kodakarens... 281 9e-74
gb|ABD32397.1| Mevalonate and galactokinase [Medicago trunc... 280 2e-73
ref|NP_126232.1| mevalonate kinase [Pyrococcus abyssi GE5] ... 278 5e-73
ref|XP_452532.1| unnamed protein product [Kluyveromyces lac... 278 6e-73
ref|XP_645383.1| hypothetical protein DDBDRAFT_0168621 [Dic... 277 1e-72
ref|NP_143478.1| mevalonate kinase [Pyrococcus horikoshii O... 277 1e-72
ref|XP_446138.1| unnamed protein product [Candida glabrata]... 274 7e-72
gb|AAX46707.1| mevalonate kinase [Bos taurus] 274 1e-71
ref|NP_579366.1| mevalonate kinase [Pyrococcus furiosus DSM... 273 2e-71
ref|XP_761643.1| hypothetical protein UM05496.1 [Ustilago m... 272 3e-71
ref|XP_500956.1| hypothetical protein [Yarrowia lipolytica]... 271 6e-71
ref|XP_001608063.1| PREDICTED: similar to mevalonate kinase... 270 1e-70
ref|XP_972334.1| PREDICTED: similar to mevalonate kinase [T... 268 6e-70
ref|XP_624545.2| PREDICTED: similar to Mevalonate kinase (M... 266 2e-69
gb|AAL31086.1|AC091749_15 putative mevalonate kinase [Oryza... 263 2e-68
ref|NP_001027412.1| CG33671 CG33671-PA [Drosophila melanoga... 262 3e-68
ref|XP_001730996.1| hypothetical protein MGL_1995 [Malassez... 259 2e-67
gb|ABR68258.1| mevalonate kinase [Monodelphis domestica] 249 2e-64
ref|XP_319701.4| AGAP008947-PA [Anopheles gambiae str. PEST... 249 3e-64
ref|YP_658630.1| mevalonate kinase [Haloquadratum walsbyi D... 245 4e-63
ref|ZP_00829490.1| COG0153: Galactokinase [Yersinia frederi... 244 1e-62
ref|NP_633786.1| mevalonate kinase [Methanosarcina mazei Go... 243 2e-62
ref|ZP_00832046.1| COG0153: Galactokinase [Yersinia interme... 242 5e-62
ref|ZP_00824475.1| COG0153: Galactokinase [Yersinia mollare... 241 1e-61
ref|ZP_03999700.1| mevalonate kinase [Halogeometricum borin... 240 1e-61
ref|ZP_00820945.1| COG0153: Galactokinase [Yersinia bercovi... 239 3e-61
ref|YP_920295.1| mevalonate kinase [Thermofilum pendens Hrk... 237 8e-61
ref|YP_001040239.1| mevalonate kinase [Staphylothermus mari... 237 1e-60
ref|NP_404747.1| galactokinase [Yersinia pestis CO92] >gi|2... 236 3e-60
ref|NP_001022868.1| Y42G9A.4c [Caenorhabditis elegans] >gi|... 235 6e-60
ref|NP_001022867.1| Y42G9A.4b [Caenorhabditis elegans] >gi|... 235 6e-60
ref|YP_001581649.1| mevalonate kinase [Nitrosopumilus marit... 234 9e-60
ref|YP_069704.1| galactokinase [Yersinia pseudotuberculosis... 234 1e-59
ref|NP_001022869.1| Y42G9A.4d [Caenorhabditis elegans] >gi|... 233 2e-59
ref|NP_001072199.1| hypothetical protein LOC779645 [Xenopus... 231 9e-59
ref|ZP_02015315.1| mevalonate kinase [Halorubrum lacusprofu... 230 1e-58
ref|YP_566996.1| mevalonate kinase [Methanococcoides burton... 228 7e-58
ref|XP_001900710.1| mevalonate kinase family protein [Brugi... 228 7e-58
ref|YP_001334437.1| galactokinase [Klebsiella pneumoniae su... 226 2e-57
ref|NP_001085920.1| MGC82807 protein [Xenopus laevis] >gi|4... 226 2e-57
ref|YP_327075.1| mevalonate kinase [Natronomonas pharaonis ... 226 3e-57
gb|EAZ05750.1| hypothetical protein OsI_026982 [Oryza sativ... 226 3e-57
ref|YP_001140151.1| galactokinase [Aeromonas salmonicida su... 225 4e-57
pdb|1VIS|A Chain A, Crystal Structure Of Mevalonate Kinase 225 5e-57
pdb|1KKH|A Chain A, Crystal Structure Of The Methanococcus ... 224 7e-57
ref|NP_248080.1| mevalonate kinase [Methanocaldococcus jann... 224 7e-57
ref|YP_684687.1| mevalonate kinase [uncultured methanogenic... 224 1e-56
ref|NP_615566.1| mevalonate kinase [Methanosarcina acetivor... 224 1e-56
ref|ZP_03943398.1| possible mevalonate kinase [Lactobacillu... 223 1e-56
ref|YP_842907.1| mevalonate kinase [Methanosaeta thermophil... 223 2e-56
ref|YP_001477523.1| galactokinase [Serratia proteamaculans ... 223 2e-56
ref|ZP_03954541.1| possible mevalonate kinase [Lactobacillu... 222 4e-56
ref|NP_280049.1| Mvk [Halobacterium sp. NRC-1] >gi|16923595... 222 4e-56
emb|CAN77024.1| hypothetical protein [Vitis vinifera] 222 5e-56
ref|YP_134862.1| mevalonate kinase [Haloarcula marismortui ... 221 6e-56
ref|NP_001008283.1| galactokinase 1 [Rattus norvegicus] >gi... 221 7e-56
gb|EAW89316.1| galactokinase 1 [Homo sapiens] 221 8e-56
ref|ZP_03940390.1| possible mevalonate kinase [Lactobacillu... 221 8e-56
gb|EAZ15677.1| hypothetical protein OsJ_029886 [Oryza sativ... 221 8e-56
gb|EEH92189.1| galactokinase [Citrobacter sp. 30_2] 221 9e-56
ref|YP_304960.1| mevalonate kinase [Methanosarcina barkeri ... 220 1e-55
ref|ZP_03871887.1| mevalonate kinase [Halorhabdus utahensis... 220 2e-55
ref|ZP_03835936.1| galactokinase [Citrobacter youngae ATCC ... 220 2e-55
ref|NP_001092851.1| galactokinase 1 [Bos taurus] >gi|148878... 220 2e-55
sp|A6H768|GALK1_BOVIN Galactokinase (Galactose kinase) 220 2e-55
ref|NP_000145.1| galactokinase 1 [Homo sapiens] >gi|1730187... 219 2e-55
ref|YP_943380.1| galactokinase [Psychromonas ingrahamii 37]... 219 2e-55
gb|AAP36280.1| Homo sapiens galactokinase 1 [synthetic cons... 219 2e-55
ref|NP_001003104.1| galactokinase 1 [Canis lupus familiaris... 219 2e-55
ref|NP_058601.2| galactokinase 1 [Mus musculus] >gi|8650486... 219 3e-55
ref|ZP_01189626.1| Galactokinase [Halothermothrix orenii H ... 219 3e-55
sp|Q9R0N0|GALK1_MOUSE Galactokinase (Galactose kinase) >gi|... 219 3e-55
gb|AAH50151.1| Galactokinase 1 [Mus musculus] 219 3e-55
ref|XP_001492114.1| PREDICTED: similar to galactokinase [Eq... 219 3e-55
dbj|BAB27400.1| unnamed protein product [Mus musculus] >gi|... 219 4e-55
dbj|BAB26864.1| unnamed protein product [Mus musculus] 219 4e-55
ref|YP_804427.1| Mevalonate kinase [Pediococcus pentosaceus... 219 5e-55
ref|YP_001095396.1| galactokinase [Shewanella loihica PV-4]... 219 5e-55
gb|EDN13154.1| galactokinase [Vibrio cholerae RC385] 218 7e-55
ref|ZP_01482152.1| hypothetical protein VchoR_02001931 [Vib... 217 1e-54
gb|EEJ85937.1| galactokinase [Meiothermus ruber DSM 1279] 217 1e-54
ref|ZP_01695505.1| mevalonate kinase [Bacillus coagulans 36... 217 2e-54
gb|EEK05491.1| galactokinase [Alicyclobacillus acidocaldari... 217 2e-54
ref|NP_623503.1| galactokinase [Thermoanaerobacter tengcong... 217 2e-54
ref|ZP_01956996.1| galactokinase [Vibrio cholerae MZO-3] >g... 217 2e-54
ref|NP_266560.1| mevalonate kinase [Lactococcus lactis subs... 215 3e-54
ref|ZP_02184438.1| galactokinase [Carnobacterium sp. AT7] >... 215 4e-54
gb|EEJ90835.1| galactokinase [Meiothermus silvanus DSM 9946] 215 4e-54
ref|ZP_01948739.1| galactokinase [Vibrio cholerae 1587] >gi... 215 4e-54
ref|YP_001547075.1| mevalonate kinase [Herpetosiphon aurant... 215 4e-54
ref|NP_001006002.1| galactokinase 1 [Danio rerio] >gi|53734... 215 5e-54
ref|YP_001620791.1| mevalonate kinase [Acholeplasma laidlaw... 215 5e-54
gb|EAY78050.1| hypothetical protein OsI_032009 [Oryza sativ... 215 6e-54
ref|ZP_01544345.1| mevalonate kinase [Oenococcus oeni ATCC ... 215 7e-54
ref|YP_001908203.1| Galactokinase [Erwinia tasmaniensis] >g... 214 7e-54
ref|YP_535576.1| Phosphomevalonate kinase [Lactobacillus sa... 214 8e-54
ref|YP_001431124.1| galactokinase [Roseiflexus castenholzii... 214 1e-53
ref|YP_001142186.1| galactokinase [Aeromonas salmonicida su... 214 1e-53
ref|ZP_04008555.1| mevalonate kinase [Lactobacillus salivar... 214 1e-53
ref|YP_810664.1| Mevalonate kinase [Oenococcus oeni PSU-1] ... 214 1e-53
ref|YP_001877582.1| galactokinase [Akkermansia muciniphila ... 213 2e-53
ref|YP_808480.1| Mevalonate kinase [Lactococcus lactis subs... 212 3e-53
ref|ZP_03959181.1| phosphomevalonate kinase [Lactobacillus ... 212 3e-53
ref|YP_535578.1| Mevalonate kinase [Lactobacillus salivariu... 212 3e-53
ref|YP_001031775.1| Mvk protein [Lactococcus lactis subsp. ... 212 4e-53
ref|ZP_01273285.1| Gram positive phosphomevalonate kinase [... 211 7e-53
emb|CAF89842.1| unnamed protein product [Tetraodon nigrovir... 210 1e-52
ref|ZP_02950336.1| galactokinase [Clostridium butyricum 552... 210 1e-52
ref|YP_001844010.1| phosphomevalonate kinase [Lactobacillus... 210 2e-52
ref|ZP_03957037.1| mevalonate kinase [Lactobacillus ruminis... 210 2e-52
ref|ZP_03957035.1| phosphomevalonate kinase [Lactobacillus ... 210 2e-52
ref|YP_001276466.1| mevalonate kinase [Roseiflexus sp. RS-1... 209 2e-52
ref|ZP_03974669.1| phosphomevalonate kinase [Lactobacillus ... 209 3e-52
ref|YP_001792272.1| galactokinase [Leptothrix cholodnii SP-... 209 4e-52
ref|XP_001600084.1| PREDICTED: similar to Galactokinase 1 [... 209 4e-52
ref|ZP_01960689.1| hypothetical protein BACCAC_02307 [Bacte... 208 6e-52
ref|YP_514052.1| Galactokinase [Francisella tularensis subs... 208 7e-52
ref|YP_002755338.1| galactokinase [Acidobacterium capsulatu... 207 1e-51
ref|NP_438979.2| galactokinase [Haemophilus influenzae Rd K... 207 1e-51
ref|YP_001121649.1| galactokinase [Francisella tularensis s... 207 1e-51
gb|AAC22478.1| galactokinase (galK) [Haemophilus influenzae... 207 1e-51
ref|ZP_01787913.1| galactokinase [Haemophilus influenzae 36... 207 1e-51
ref|XP_001467381.1| mevalonate kinase [Leishmania infantum ... 207 2e-51
ref|YP_898331.1| galactokinase [Francisella tularensis subs... 207 2e-51
ref|YP_170412.1| Galactokinase [Francisella tularensis subs... 207 2e-51
gb|EDN37489.1| hypothetical protein FTDG_00277 [Francisella... 207 2e-51
ref|YP_001678584.1| galactokinase [Francisella philomiragia... 207 2e-51
ref|ZP_03954539.1| phosphomevalonate kinase [Lactobacillus ... 206 2e-51
ref|XP_001685041.1| mevalonate kinase, putative [Leishmania... 206 2e-51
gb|AAG02440.1|AF290093_1 mevalonate kinase [Enterococcus fa... 206 2e-51
ref|ZP_03943396.1| phosphomevalonate kinase [Lactobacillus ... 206 2e-51
ref|NP_814642.1| mevalonate kinase [Enterococcus faecalis V... 206 3e-51
pdb|2HFU|A Chain A, Crystal Structure Of L. Major Mevalonat... 206 3e-51
ref|ZP_00155897.2| COG0153: Galactokinase [Haemophilus infl... 206 3e-51
ref|YP_001812878.1| galactokinase [Exiguobacterium sibiricu... 206 3e-51
ref|XP_001567071.1| mevalonate kinase, putative [Leishmania... 205 3e-51
gb|EDN36035.1| galactokinase [Francisella tularensis subsp.... 205 4e-51
ref|ZP_03940388.1| phosphomevalonate kinase [Lactobacillus ... 205 4e-51
ref|ZP_03845964.1| mevalonate kinase [Lactobacillus sakei s... 205 4e-51
ref|YP_001292759.1| galactokinase [Haemophilus influenzae P... 205 5e-51
ref|ZP_03947872.1| mevalonate kinase [Enterococcus faecalis... 205 6e-51
ref|YP_395519.1| Mevalonate kinase [Lactobacillus sakei sub... 205 7e-51
ref|YP_248526.1| galactokinase [Haemophilus influenzae 86-0... 204 7e-51
ref|YP_001431846.1| mevalonate kinase [Roseiflexus castenho... 204 7e-51
Sequences not found previously or not previously below threshold:
ref|YP_001007108.1| galactokinase [Yersinia enterocolitica ... 234 1e-59
gb|ABC98030.1| GalK [Shigella flexneri] >gi|86516678|gb|ABC... 229 4e-58
ref|ZP_01868020.1| galactokinase [Vibrio shilonii AK1] >gi|... 228 7e-58
gb|ABC98001.1| GalK [Shigella boydii] 227 8e-58
ref|YP_001571187.1| hypothetical protein SARI_02168 [Salmon... 227 9e-58
gb|ABC98023.1| GalK [Shigella dysenteriae] 227 1e-57
gb|ABC97999.1| GalK [Shigella boydii] 227 1e-57
ref|NP_752763.1| galactokinase [Escherichia coli CFT073] >g... 227 1e-57
ref|YP_001588958.1| hypothetical protein SPAB_02747 [Salmon... 227 1e-57
ref|YP_215759.1| galactokinase [Salmonella enterica subsp. ... 227 1e-57
gb|ABC98026.1| GalK [Shigella flexneri] 227 1e-57
ref|NP_706484.1| galactokinase [Shigella flexneri 2a str. 3... 227 2e-57
gb|ABC98038.1| GalK [Escherichia coli] 227 2e-57
ref|YP_001879407.1| galactokinase [Shigella boydii CDC 3083... 227 2e-57
ref|NP_308812.1| galactokinase [Escherichia coli O157:H7 st... 226 2e-57
ref|NP_286478.1| galactokinase [Escherichia coli O157:H7 ED... 226 2e-57
ref|ZP_02700220.1| galactokinase [Salmonella enterica subsp... 226 2e-57
ref|ZP_02649015.1| galactokinase [Salmonella enterica subsp... 226 2e-57
gb|ABC98013.1| GalK [Shigella boydii] 226 2e-57
ref|ZP_02561120.1| galactokinase [Salmonella enterica subsp... 226 2e-57
ref|ZP_02564893.1| galactokinase [Salmonella enterica subsp... 226 2e-57
ref|YP_402378.1| galactokinase [Shigella dysenteriae Sd197]... 226 2e-57
ref|NP_455316.1| galactokinase [Salmonella enterica subsp. ... 226 2e-57
gb|ABC97998.1| GalK [Shigella boydii] >gi|86516632|gb|ABC98... 226 2e-57
gb|ABC98018.1| GalK [Shigella dysenteriae] 226 2e-57
ref|ZP_02344312.1| galactokinase [Salmonella enterica subsp... 226 2e-57
ref|ZP_02665563.1| galactokinase [Salmonella enterica subsp... 226 2e-57
ref|YP_001742860.1| galactokinase [Escherichia coli SMS-3-5... 226 2e-57
gb|AAA72509.1| galK 226 2e-57
gb|ABC98032.1| GalK [Shigella flexneri] 226 2e-57
ref|NP_459753.1| galactokinase [Salmonella typhimurium LT2]... 226 2e-57
gb|ABC98016.1| GalK [Shigella dysenteriae] >gi|86516650|gb|... 226 3e-57
ref|ZP_02341305.1| galactokinase [Salmonella enterica subsp... 226 3e-57
gb|AAX07752.1| galactokinase [Klebsiella pneumoniae] 226 3e-57
ref|YP_151198.1| galactokinase [Salmonella enterica subsp. ... 226 3e-57
ref|ZP_00709332.1| COG0153: Galactokinase [Escherichia coli... 225 5e-57
ref|YP_407124.1| galactokinase [Shigella boydii Sb227] >gi|... 224 8e-57
ref|YP_001457550.1| galactokinase [Escherichia coli HS] >gi... 224 1e-56
gb|ABC98007.1| GalK [Shigella boydii] 224 1e-56
ref|ZP_01162250.1| galactokinase [Photobacterium sp. SKA34]... 224 1e-56
ref|ZP_02903417.1| galactokinase [Escherichia albertii TW07... 223 2e-56
gb|ABC98014.1| GalK [Shigella dysenteriae] 223 2e-56
gb|AAC48872.1| galactokinase [Cloning vector pAL-Z] >gi|250... 223 2e-56
ref|YP_688144.1| galactokinase [Shigella flexneri 5 str. 84... 223 2e-56
ref|YP_206313.1| galactokinase [Vibrio fischeri ES114] >gi|... 223 2e-56
ref|YP_001175980.1| galactokinase [Enterobacter sp. 638] >g... 223 2e-56
gb|AAA27113.1| galactokinase (galK) (EC 2.7.1.6) 222 5e-56
ref|YP_001453936.1| hypothetical protein CKO_02378 [Citroba... 222 5e-56
ref|ZP_01813325.1| galactokinase [Vibrionales bacterium SWA... 221 6e-56
ref|ZP_01986705.1| galactokinase [Vibrio harveyi HY01] >gi|... 220 1e-55
ref|YP_001438669.1| hypothetical protein ESA_02588 [Enterob... 220 2e-55
ref|ZP_02137458.1| galactokinase [Vibrio fischeri MJ11] >gi... 219 2e-55
ref|NP_760656.1| galactokinase [Vibrio vulnificus CMCP6] >g... 219 2e-55
ref|ZP_01475175.1| hypothetical protein VEx2w_02002241 [Vib... 219 3e-55
ref|YP_001662721.1| galactokinase [Thermoanaerobacter sp. X... 219 3e-55
ref|NP_935430.1| galactokinase [Vibrio vulnificus YJ016] >g... 219 3e-55
ref|NP_798777.1| galactokinase [Vibrio parahaemolyticus RIM... 219 4e-55
ref|ZP_01234207.1| galactokinase [Vibrio angustum S14] >gi|... 219 4e-55
ref|YP_001446502.1| galactokinase [Vibrio harveyi ATCC BAA-... 218 8e-55
ref|ZP_02196242.1| galactokinase [Vibrio campbellii AND4] >... 217 1e-54
ref|ZP_01216001.1| galactokinase [Psychromonas sp. CNPT3] >... 217 1e-54
ref|YP_001664603.1| galactokinase [Thermoanaerobacter pseud... 217 1e-54
ref|ZP_01896579.1| galactokinase [Moritella sp. PE36] >gi|1... 217 1e-54
ref|ZP_00990233.1| galactokinase [Vibrio splendidus 12B01] ... 217 2e-54
ref|YP_858529.1| galactokinase [Aeromonas hydrophila subsp.... 215 4e-54
ref|YP_130284.1| galactokinase [Photobacterium profundum SS... 215 6e-54
ref|NP_231235.1| galactokinase [Vibrio cholerae O1 biovar e... 214 8e-54
ref|ZP_01218471.1| galactokinase [Photobacterium profundum ... 214 1e-53
ref|ZP_01982860.1| galactokinase [Vibrio cholerae 623-39] >... 214 1e-53
ref|ZP_01477813.1| hypothetical protein VchoM_02003065 [Vib... 214 1e-53
ref|ZP_01977521.1| galactokinase [Vibrio cholerae MZO-2] >g... 213 2e-53
ref|ZP_03840717.1| galactokinase [Proteus mirabilis ATCC 29... 213 2e-53
ref|ZP_03968958.1| galactokinase [Sphingobacterium spiritiv... 211 9e-53
ref|ZP_02961318.1| hypothetical protein PROSTU_03341 [Provi... 210 2e-52
ref|XP_001377585.1| PREDICTED: similar to galactokinase [Mo... 210 2e-52
ref|YP_660230.1| galactokinase [Pseudoalteromonas atlantica... 209 3e-52
ref|NP_391699.1| galactokinase [Bacillus subtilis subsp. su... 209 3e-52
gb|EDN15462.1| galactokinase [Vibrio cholerae AM-19226] 209 5e-52
ref|ZP_02914868.1| galactokinase [Geobacillus sp. WCH70] >g... 208 5e-52
ref|ZP_01967073.1| hypothetical protein RUMTOR_00615 [Rumin... 208 6e-52
ref|ZP_02171442.1| binding-protein-dependent transport syst... 208 7e-52
ref|NP_927924.1| galactokinase [Photorhabdus luminescens su... 207 9e-52
ref|ZP_02272294.1| galactokinase [Fusobacterium nucleatum s... 207 1e-51
ref|YP_001875501.1| galactokinase [Elusimicrobium minutum P... 207 2e-51
ref|NP_602892.1| galactokinase [Fusobacterium nucleatum sub... 207 2e-51
ref|ZP_00143687.1| Galactokinase [Fusobacterium nucleatum s... 205 3e-51
ref|NP_349561.1| galactokinase [Clostridium acetobutylicum ... 205 4e-51
ref|NP_809283.1| galactokinase [Bacteroides thetaiotaomicro... 205 5e-51
ref|ZP_02954223.1| galactokinase [Clostridium perfringens D... 205 6e-51
ref|ZP_01169901.1| galactokinase [Bacillus sp. NRRL B-14911... 205 6e-51
ref|ZP_02637705.1| galactokinase [Clostridium perfringens B... 204 7e-51
ref|YP_698665.1| galactokinase [Clostridium perfringens SM1... 204 8e-51
>emb|CAA53059.1| unnamed protein product [Hepatitis B virus]
Length = 557
Score = 438 bits (1127), Expect = e-121, Method: Composition-based stats.
Identities = 396/396 (100%), Positives = 396/396 (100%)
Query: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 60
MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR
Sbjct: 162 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 221
Query: 61 AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC 120
AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC
Sbjct: 222 AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC 281
Query: 121 RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE 180
RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE
Sbjct: 282 RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE 341
Query: 181 DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP 240
DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP
Sbjct: 342 DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP 401
Query: 241 RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM 300
RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM
Sbjct: 402 RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM 461
Query: 301 NQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL 360
NQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL
Sbjct: 462 NQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL 521
Query: 361 TSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL 396
TSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL
Sbjct: 522 TSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL 557
>ref|XP_001105759.1| PREDICTED: mevalonate kinase isoform 2 [Macaca mulatta]
ref|XP_001105815.1| PREDICTED: mevalonate kinase isoform 3 [Macaca mulatta]
Length = 396
Score = 428 bits (1100), Expect = e-118, Method: Composition-based stats.
Identities = 381/396 (96%), Positives = 383/396 (96%)
Query: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 60
MLSEVLLVSAPGKVILHGEHAVVHGKVALAV+LNLRTFLRLQPHSNGKVDLSLPNIGIK
Sbjct: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVALNLRTFLRLQPHSNGKVDLSLPNIGIKW 60
Query: 61 AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC 120
AWDVARLQ LDTSFLEQGD TTPT E VEKLKEVAGLPDDCAVTE LAVLAFLYLYLSIC
Sbjct: 61 AWDVARLQLLDTSFLEQGDATTPTPELVEKLKEVAGLPDDCAVTESLAVLAFLYLYLSIC 120
Query: 121 RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE 180
RKQRALPSLDIVVWSELP GAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGD VNRWTKE
Sbjct: 121 RKQRALPSLDIVVWSELPHGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDRVNRWTKE 180
Query: 181 DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP 240
DLELINKWAFQGER+IHGNPSGVDNAVSTWGGALRY QGKISSLKR PALQILLTNTKVP
Sbjct: 181 DLELINKWAFQGERVIHGNPSGVDNAVSTWGGALRYQQGKISSLKRPPALQILLTNTKVP 240
Query: 241 RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM 300
RNTR LVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM
Sbjct: 241 RNTRTLVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM 300
Query: 301 NQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL 360
NQHHLNALGVGHASLDQLCQVTRA GLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL
Sbjct: 301 NQHHLNALGVGHASLDQLCQVTRAHGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL 360
Query: 361 TSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL 396
TSCGFDC ETSIGAPGVSIHSATSLDSRVQQALDGL
Sbjct: 361 TSCGFDCWETSIGAPGVSIHSATSLDSRVQQALDGL 396
>dbj|BAD92959.1| mevalonate kinase variant [Homo sapiens]
Length = 421
Score = 425 bits (1092), Expect = e-117, Method: Composition-based stats.
Identities = 395/396 (99%), Positives = 396/396 (100%)
Query: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 60
MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDL+LPNIGIKR
Sbjct: 26 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLNLPNIGIKR 85
Query: 61 AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC 120
AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC
Sbjct: 86 AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC 145
Query: 121 RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE 180
RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE
Sbjct: 146 RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE 205
Query: 181 DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP 240
DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP
Sbjct: 206 DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP 265
Query: 241 RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM 300
RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM
Sbjct: 266 RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM 325
Query: 301 NQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL 360
NQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL
Sbjct: 326 NQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL 385
Query: 361 TSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL 396
TSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL
Sbjct: 386 TSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL 421
>ref|NP_000422.1| mevalonate kinase [Homo sapiens]
ref|NP_001107657.1| mevalonate kinase [Homo sapiens]
sp|Q03426|KIME_HUMAN Mevalonate kinase (MK)
gb|AAB59362.1| mevalonate kinase
emb|CAA53060.1| unnamed protein product [Homo sapiens]
gb|AAF82407.1| mevalonate kinase [Homo sapiens]
gb|AAH16140.1| MVK protein [Homo sapiens]
gb|EAW97872.1| mevalonate kinase (mevalonic aciduria), isoform CRA_c [Homo
sapiens]
gb|EAW97873.1| mevalonate kinase (mevalonic aciduria), isoform CRA_c [Homo
sapiens]
gb|ABM82015.1| mevalonate kinase (mevalonic aciduria) [synthetic construct]
gb|ABM85197.1| mevalonate kinase (mevalonic aciduria) [synthetic construct]
Length = 396
Score = 424 bits (1091), Expect = e-117, Method: Composition-based stats.
Identities = 396/396 (100%), Positives = 396/396 (100%)
Query: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 60
MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR
Sbjct: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 60
Query: 61 AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC 120
AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC
Sbjct: 61 AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC 120
Query: 121 RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE 180
RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE
Sbjct: 121 RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE 180
Query: 181 DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP 240
DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP
Sbjct: 181 DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP 240
Query: 241 RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM 300
RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM
Sbjct: 241 RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM 300
Query: 301 NQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL 360
NQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL
Sbjct: 301 NQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL 360
Query: 361 TSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL 396
TSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL
Sbjct: 361 TSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL 396
>gb|AAQ02416.1| mevalonate kinase [synthetic construct]
Length = 397
Score = 424 bits (1091), Expect = e-117, Method: Composition-based stats.
Identities = 396/396 (100%), Positives = 396/396 (100%)
Query: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 60
MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR
Sbjct: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 60
Query: 61 AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC 120
AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC
Sbjct: 61 AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC 120
Query: 121 RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE 180
RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE
Sbjct: 121 RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE 180
Query: 181 DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP 240
DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP
Sbjct: 181 DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP 240
Query: 241 RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM 300
RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM
Sbjct: 241 RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM 300
Query: 301 NQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL 360
NQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL
Sbjct: 301 NQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL 360
Query: 361 TSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL 396
TSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL
Sbjct: 361 TSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL 396
>ref|XP_001496887.1| PREDICTED: similar to mevalonate kinase [Equus caballus]
Length = 407
Score = 402 bits (1034), Expect = e-110, Method: Composition-based stats.
Identities = 335/397 (84%), Positives = 360/397 (90%), Gaps = 1/397 (0%)
Query: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 60
MLSEVLLVSAPGKVILHGEHAVVHGKVALAV+LNLRTFLRLQPHS GKV L+LPNIGIK+
Sbjct: 11 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVALNLRTFLRLQPHSTGKVGLNLPNIGIKQ 70
Query: 61 AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTER-LAVLAFLYLYLSI 119
AWDVA LQ LDTSFLEQGD+T T EQVEKLKEVAG P+DCA + LAVLAFL+LYLSI
Sbjct: 71 AWDVASLQLLDTSFLEQGDITALTPEQVEKLKEVAGCPEDCANDHKWLAVLAFLFLYLSI 130
Query: 120 CRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTK 179
CRKQRALPSLD+ VWSELPPGAGLGSSAAYSVCLAAA L CEEIPNPLKDG+ +RWT+
Sbjct: 131 CRKQRALPSLDVTVWSELPPGAGLGSSAAYSVCLAAAFLAACEEIPNPLKDGEPTSRWTE 190
Query: 180 EDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKV 239
EDLELINKWAFQGER+IHGNPSGVDN VSTWGGALRY QGKISSLKR PAL+ILLTNTKV
Sbjct: 191 EDLELINKWAFQGERVIHGNPSGVDNTVSTWGGALRYQQGKISSLKRPPALKILLTNTKV 250
Query: 240 PRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELID 299
PR+T+ALVAGVRNRLLKFPEIVAP+LTSI+AISLECERVL EM AP P YLVLEELID
Sbjct: 251 PRSTKALVAGVRNRLLKFPEIVAPVLTSIEAISLECERVLAEMASAPTPGHYLVLEELID 310
Query: 300 MNQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQA 359
MNQHHLNALGVGHASLDQLCQVT A GLHSKLTG GGGGCGITLL+P L++ EVEA KQA
Sbjct: 311 MNQHHLNALGVGHASLDQLCQVTTAHGLHSKLTGGGGGGCGITLLRPDLQRLEVEAAKQA 370
Query: 360 LTSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL 396
LT CGFDC ETSIGAPGVS+H+ATSLD+ + QALDG+
Sbjct: 371 LTGCGFDCWETSIGAPGVSVHAATSLDAPILQALDGI 407
>ref|XP_543435.2| PREDICTED: similar to Mevalonate kinase (MK) [Canis familiaris]
Length = 409
Score = 402 bits (1032), Expect = e-110, Method: Composition-based stats.
Identities = 335/400 (83%), Positives = 359/400 (89%), Gaps = 4/400 (1%)
Query: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 60
MLSEVLLVSAPGKVILHGEHAVVHGK+ALAV+LNLRTFLRLQPHSNGK+ L+LPNIG+KR
Sbjct: 10 MLSEVLLVSAPGKVILHGEHAVVHGKIALAVALNLRTFLRLQPHSNGKMCLNLPNIGVKR 69
Query: 61 AWDVARLQSLDTSFLEQGDVTT----PTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLY 116
AWDVARLQ DTSFLE G+ T PTSEQVEKLKEVAG+P D A E LAVLAFLYLY
Sbjct: 70 AWDVARLQLQDTSFLEPGNATGDAAAPTSEQVEKLKEVAGIPKDGADPECLAVLAFLYLY 129
Query: 117 LSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNR 176
LSICRKQR LPSLDI VWSELP GAGLGSSAAYSVCLAAALLT CE IPNP +G+ +R
Sbjct: 130 LSICRKQRTLPSLDITVWSELPTGAGLGSSAAYSVCLAAALLTACEAIPNPQNNGESASR 189
Query: 177 WTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTN 236
WT EDLELINKWAFQGERMIHGNPSGVDN +STWGGALRY QGKISS+KR PAL+ILLTN
Sbjct: 190 WTMEDLELINKWAFQGERMIHGNPSGVDNTISTWGGALRYQQGKISSIKRLPALKILLTN 249
Query: 237 TKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEE 296
TKVPR+T+ALVA VR+RLLKFPEIVAPLLTSI+AISLECER L EM APAPE YLVLEE
Sbjct: 250 TKVPRSTKALVASVRSRLLKFPEIVAPLLTSINAISLECERTLEEMASAPAPEHYLVLEE 309
Query: 297 LIDMNQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEAT 356
LID+NQHHLNALGVGHASLDQLCQVT A GLHSKLTGAGGGGCGITLL+P LEQP+VEA
Sbjct: 310 LIDINQHHLNALGVGHASLDQLCQVTMAHGLHSKLTGAGGGGCGITLLRPDLEQPKVEAM 369
Query: 357 KQALTSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL 396
KQALTSCGFDC ET IGAPG+SIHSA SLD++VQ+ALDGL
Sbjct: 370 KQALTSCGFDCWETRIGAPGISIHSAASLDTQVQRALDGL 409
>ref|NP_001015528.1| mevalonate kinase [Bos taurus]
sp|Q5E9T8|KIME_BOVIN Mevalonate kinase (MK)
gb|AAX08849.1| mevalonate kinase [Bos taurus]
gb|AAI04541.1| Mevalonate kinase (mevalonic aciduria) [Bos taurus]
Length = 396
Score = 400 bits (1029), Expect = e-110, Method: Composition-based stats.
Identities = 327/396 (82%), Positives = 352/396 (88%)
Query: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 60
MLSEVLLVSAPGKVILHGEHAVVHGKVALAV+LNLRTFLRLQPHSNG+V L+LPNIG++R
Sbjct: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVALNLRTFLRLQPHSNGRVGLNLPNIGVRR 60
Query: 61 AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC 120
AWDVA LQ LDTSFL GD T++ VEKLKEVAG P DC E LAVLAFLYLYLSIC
Sbjct: 61 AWDVASLQLLDTSFLGHGDSAALTAKHVEKLKEVAGFPKDCVDPEHLAVLAFLYLYLSIC 120
Query: 121 RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE 180
+ QRALPSLDI VWSELP GAGLGSSAAYSVCLAAALLT CEEIPNPLKDG+ RWT+E
Sbjct: 121 QSQRALPSLDITVWSELPTGAGLGSSAAYSVCLAAALLTACEEIPNPLKDGEAAGRWTEE 180
Query: 181 DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP 240
+LELINKWAFQGER+IHGNPSGVDNAVSTWGGALRY QGKISSLKR P L+ILL NTKVP
Sbjct: 181 NLELINKWAFQGERVIHGNPSGVDNAVSTWGGALRYQQGKISSLKRPPVLKILLINTKVP 240
Query: 241 RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM 300
R+T+ LVA VR+RLLKFPEIVAPLLTSIDAISLECERVLGEM AP PE YL LEELIDM
Sbjct: 241 RSTKVLVANVRSRLLKFPEIVAPLLTSIDAISLECERVLGEMAAAPTPEHYLTLEELIDM 300
Query: 301 NQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL 360
NQHHLNALGVGHASLDQLCQVT A GLHSKLTGAGGGGCGITLL+P +E+P VEATK+AL
Sbjct: 301 NQHHLNALGVGHASLDQLCQVTTAHGLHSKLTGAGGGGCGITLLRPDVERPAVEATKRAL 360
Query: 361 TSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL 396
+ CGFDC ETS+GAPGVS+H+A SLD+ VQQ LD L
Sbjct: 361 SGCGFDCWETSVGAPGVSVHTAASLDASVQQGLDSL 396
>gb|AAX08684.1| mevalonate kinase [Bos taurus]
Length = 396
Score = 400 bits (1028), Expect = e-109, Method: Composition-based stats.
Identities = 326/396 (82%), Positives = 351/396 (88%)
Query: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 60
MLSEVLLVSAPGKVILHGEHAVVHGKVALAV+LNLRTFLRLQPHSNG+V L+LPNIG++R
Sbjct: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVALNLRTFLRLQPHSNGRVGLNLPNIGVRR 60
Query: 61 AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC 120
AWDVA LQ LDTSFL GD T++ VEKLKEVAG P DC E LAVLAFLYLYLSIC
Sbjct: 61 AWDVASLQLLDTSFLGHGDSAALTAKHVEKLKEVAGFPKDCVDPEHLAVLAFLYLYLSIC 120
Query: 121 RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE 180
+ QR LPSLDI VWSELP GAGLGSSAAYSVCLAAALLT CEEIPNPLKDG+ RWT+E
Sbjct: 121 QSQRVLPSLDITVWSELPTGAGLGSSAAYSVCLAAALLTACEEIPNPLKDGEAAGRWTEE 180
Query: 181 DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP 240
+LELINKWAFQGER+IHGNPSGVDNAVSTWGGALRY QGKISSLKR P L+ILL NTKVP
Sbjct: 181 NLELINKWAFQGERVIHGNPSGVDNAVSTWGGALRYQQGKISSLKRPPVLKILLINTKVP 240
Query: 241 RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM 300
R+T+ LVA VR+RLLKFPEIVAPLLTSIDAISLECERVLGEM AP PE YL LEELIDM
Sbjct: 241 RSTKVLVANVRSRLLKFPEIVAPLLTSIDAISLECERVLGEMAAAPTPEHYLTLEELIDM 300
Query: 301 NQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL 360
NQHHLNALGVGHASLDQLCQVT A GLHSKLTGAGGGGCGITLL+P +E+P VEATK+AL
Sbjct: 301 NQHHLNALGVGHASLDQLCQVTTAHGLHSKLTGAGGGGCGITLLRPDVERPAVEATKRAL 360
Query: 361 TSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL 396
+ CGFDC ETS+GAPGVS+H+A SLD+ VQQ LD L
Sbjct: 361 SGCGFDCWETSVGAPGVSVHTAASLDASVQQGLDSL 396
>ref|XP_001364115.1| PREDICTED: similar to mevalonate kinase [Monodelphis domestica]
Length = 396
Score = 390 bits (1003), Expect = e-107, Method: Composition-based stats.
Identities = 287/396 (72%), Positives = 327/396 (82%)
Query: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 60
ML E LLVSAPGKVILHGEHAVVHGKVALA +LNLRTFLR++PH +GKV L LPN+ R
Sbjct: 1 MLPETLLVSAPGKVILHGEHAVVHGKVALAEALNLRTFLRMRPHKDGKVRLVLPNLETSR 60
Query: 61 AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC 120
WDV++LQ L SFL+ G+ T PT+EQVEKLK AG + E LAVLAFLYLYL IC
Sbjct: 61 EWDVSKLQLLHASFLDSGEPTAPTTEQVEKLKAFAGFMTGSSERECLAVLAFLYLYLFIC 120
Query: 121 RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE 180
RK R LPS+DIVVWSELP GAGLGSSAAYSVCLAAALL CEEI N LK+G RW ++
Sbjct: 121 RKHRPLPSMDIVVWSELPTGAGLGSSAAYSVCLAAALLASCEEIMNRLKEGATSARWNED 180
Query: 181 DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP 240
+L LIN+WAF GE++IHGNPSGVDN+VSTWGGALR+ +G ISSL+R P L+ILLTNTKVP
Sbjct: 181 ELNLINRWAFLGEKVIHGNPSGVDNSVSTWGGALRFQKGNISSLQRIPVLKILLTNTKVP 240
Query: 241 RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM 300
R+T+ALVA V++RL KFPEI+ PLL SIDAIS ECERVLG M P PEQY+VLEELIDM
Sbjct: 241 RSTKALVASVKDRLAKFPEIMNPLLVSIDAISQECERVLGVMAATPTPEQYMVLEELIDM 300
Query: 301 NQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL 360
NQHHLNA+GVGH+SLD+LCQVT A GLHSKLTGAGGGGCG TLL+PGL+Q VEA KQAL
Sbjct: 301 NQHHLNAIGVGHSSLDRLCQVTAAHGLHSKLTGAGGGGCGFTLLRPGLDQSVVEAIKQAL 360
Query: 361 TSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL 396
TSCGF+C ET+IG PGVS+HS SL + V QAL+ L
Sbjct: 361 TSCGFECWETTIGGPGVSLHSEASLKANVLQALNSL 396
>gb|AAX46713.1| mevalonate kinase [Bos taurus]
Length = 440
Score = 389 bits (1000), Expect = e-106, Method: Composition-based stats.
Identities = 314/385 (81%), Positives = 338/385 (87%)
Query: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 60
MLSE LLVSAPGKVILHGEHAVVHGKVALA++LNLRTFLRLQPHSNG+V L+LPNIG++R
Sbjct: 1 MLSEALLVSAPGKVILHGEHAVVHGKVALAMALNLRTFLRLQPHSNGRVGLNLPNIGVRR 60
Query: 61 AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC 120
AWDVA LQ LDTSFL GD T++ VEKLKEVAG P DC E LAVLAFLYLYLSIC
Sbjct: 61 AWDVASLQLLDTSFLGHGDSAALTAKHVEKLKEVAGFPKDCVDPEHLAVLAFLYLYLSIC 120
Query: 121 RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE 180
+ QRALPSLDI VWSELP GAGLGSSAAYSVCLAAALLT CEEIPNPLKDG+ RWT+E
Sbjct: 121 QSQRALPSLDITVWSELPTGAGLGSSAAYSVCLAAALLTACEEIPNPLKDGEAAGRWTEE 180
Query: 181 DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP 240
+LELINKWAFQGER+IHGNPSGVDNAVSTWGGALRY QGKISSLKR P L+ILL NTKVP
Sbjct: 181 NLELINKWAFQGERVIHGNPSGVDNAVSTWGGALRYQQGKISSLKRPPVLKILLINTKVP 240
Query: 241 RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM 300
R+T+ LVA VR+RLLKFPEIVAPLLTSIDAISLECERVLGEM AP PE YL LEELIDM
Sbjct: 241 RSTKVLVANVRSRLLKFPEIVAPLLTSIDAISLECERVLGEMAAAPTPEHYLTLEELIDM 300
Query: 301 NQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL 360
NQHHLNALGVGHASLDQLCQVT A GLHSKLTGAGGGGCGITLL+P +E+PEVEATK+AL
Sbjct: 301 NQHHLNALGVGHASLDQLCQVTTAHGLHSKLTGAGGGGCGITLLRPDVERPEVEATKRAL 360
Query: 361 TSCGFDCLETSIGAPGVSIHSATSL 385
+ GFDC ETS+GAPGVS+
Sbjct: 361 SGYGFDCWETSVGAPGVSVPRPPPW 385
>ref|NP_076045.1| mevalonate kinase [Mus musculus]
sp|Q9R008|KIME_MOUSE Mevalonate kinase (MK)
gb|AAF00700.1|AF137598_1 mevalonate kinase [Mus musculus]
gb|AAH05606.1| Mevalonate kinase [Mus musculus]
Length = 395
Score = 388 bits (998), Expect = e-106, Method: Composition-based stats.
Identities = 319/393 (81%), Positives = 347/393 (88%)
Query: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 60
MLSE LLVSAPGKVILHGEHAVVHGKVALA +LNLRTFL L+P SNGKV ++LPNIGIK+
Sbjct: 1 MLSEALLVSAPGKVILHGEHAVVHGKVALAAALNLRTFLLLRPQSNGKVSVNLPNIGIKQ 60
Query: 61 AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC 120
WDV LQ LDTSFLEQGDV+ PT EQ+EKLK++ LP D A E +A+LAFLYLYL+IC
Sbjct: 61 VWDVGMLQRLDTSFLEQGDVSVPTLEQLEKLKKMGDLPRDRAGNEGMALLAFLYLYLAIC 120
Query: 121 RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE 180
RKQR LPSLD+VVWSELPPGAGLGSSAAYSVCLAAALLT CEE+ NPLKDG V+RW +E
Sbjct: 121 RKQRTLPSLDMVVWSELPPGAGLGSSAAYSVCLAAALLTACEEVSNPLKDGVSVSRWPEE 180
Query: 181 DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP 240
DL+ INKWAF+GER+IHGNPSGVDNAVSTWGGALR+ QG +SSLK P+LQILLTNTKVP
Sbjct: 181 DLKSINKWAFEGERVIHGNPSGVDNAVSTWGGALRFQQGTMSSLKSLPSLQILLTNTKVP 240
Query: 241 RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM 300
R+T+ALVA VR+RL KFPEIVAPLLTSIDAISLECERVLGEM AP PEQYLVLEELIDM
Sbjct: 241 RSTKALVAAVRSRLTKFPEIVAPLLTSIDAISLECERVLGEMVAAPVPEQYLVLEELIDM 300
Query: 301 NQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL 360
NQHHLNALGVGH SLDQLCQVT A GLHSKLTGAGGGGCGITLLKPGLEQ VEA KQAL
Sbjct: 301 NQHHLNALGVGHNSLDQLCQVTAAHGLHSKLTGAGGGGCGITLLKPGLEQATVEAAKQAL 360
Query: 361 TSCGFDCLETSIGAPGVSIHSATSLDSRVQQAL 393
TSCGFDC ETSIGAPGVS HSA ++ V+QAL
Sbjct: 361 TSCGFDCWETSIGAPGVSTHSAAAVGDPVRQAL 393
>ref|NP_112325.1| mevalonate kinase [Rattus norvegicus]
sp|P17256|KIME_RAT Mevalonate kinase (MK)
pdb|1KVK|A Chain A, The Structure Of Binary Complex Between A Mammalian
Mevalonate Kinase And Atp: Insights Into The Reaction
Mechanism And Human Inherited Disease
gb|AAA41588.1| mevalonate kinase (EC 2.7.1.36)
gb|EDM13937.1| mevalonate kinase, isoform CRA_a [Rattus norvegicus]
Length = 395
Score = 385 bits (988), Expect = e-105, Method: Composition-based stats.
Identities = 322/393 (81%), Positives = 355/393 (90%)
Query: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 60
MLSEVLLVSAPGKVILHGEHAVVHGKVALAV+LNLRTFL L+P SNGKV L+LPN+GIK+
Sbjct: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVALNLRTFLVLRPQSNGKVSLNLPNVGIKQ 60
Query: 61 AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC 120
WDVA LQ LDT FLEQGDV PT EQ+EKLK+VAGLP DC E L++LAFLYLYL+IC
Sbjct: 61 VWDVATLQLLDTGFLEQGDVPAPTLEQLEKLKKVAGLPRDCVGNEGLSLLAFLYLYLAIC 120
Query: 121 RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE 180
RKQR LPSLDI+VWSELPPGAGLGSSAAYSVC+AAALLT CEE+ NPLKD + W +E
Sbjct: 121 RKQRTLPSLDIMVWSELPPGAGLGSSAAYSVCVAAALLTACEEVTNPLKDRGSIGSWPEE 180
Query: 181 DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP 240
DL+ INKWA++GER+IHGNPSGVDN+VSTWGGALRY QGK+SSLKR PALQILLTNTKVP
Sbjct: 181 DLKSINKWAYEGERVIHGNPSGVDNSVSTWGGALRYQQGKMSSLKRLPALQILLTNTKVP 240
Query: 241 RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM 300
R+T+ALVAGVR+RL+KFPEI+APLLTSIDAISLECERVLGEM AP PEQYLVLEEL+DM
Sbjct: 241 RSTKALVAGVRSRLIKFPEIMAPLLTSIDAISLECERVLGEMAAAPVPEQYLVLEELMDM 300
Query: 301 NQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL 360
NQHHLNALGVGHASLDQLCQVT A GLHSKLTGAGGGGCGITLLKPGLE+ +VEA KQAL
Sbjct: 301 NQHHLNALGVGHASLDQLCQVTAAHGLHSKLTGAGGGGCGITLLKPGLERAKVEAAKQAL 360
Query: 361 TSCGFDCLETSIGAPGVSIHSATSLDSRVQQAL 393
T CGFDC ETSIGAPGVS+HSATS++ V+QAL
Sbjct: 361 TGCGFDCWETSIGAPGVSMHSATSIEDPVRQAL 393
>dbj|BAE28997.1| unnamed protein product [Mus musculus]
Length = 407
Score = 380 bits (977), Expect = e-104, Method: Composition-based stats.
Identities = 319/405 (78%), Positives = 347/405 (85%), Gaps = 12/405 (2%)
Query: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 60
MLSE LLVSAPGKVILHGEHAVVHGKVALA +LNLRTFL L+P SNGKV ++LPNIGIK+
Sbjct: 1 MLSEALLVSAPGKVILHGEHAVVHGKVALAAALNLRTFLLLRPQSNGKVSVNLPNIGIKQ 60
Query: 61 AWDVARLQSLDTSFL------------EQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLA 108
WDV LQ LDTSFL EQGDV+ PT EQ+EKLK++ LP D A E +A
Sbjct: 61 VWDVGMLQRLDTSFLGLSPTCLFARVTEQGDVSVPTLEQLEKLKKMGDLPRDRAGNEGMA 120
Query: 109 VLAFLYLYLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPL 168
+LAFLYLYL+ICRKQR LPSLD+VVWSELPPGAGLGSSAAYSVCLAAALLT CEE+ NPL
Sbjct: 121 LLAFLYLYLAICRKQRTLPSLDMVVWSELPPGAGLGSSAAYSVCLAAALLTACEEVSNPL 180
Query: 169 KDGDCVNRWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSP 228
KDG V+RW +EDL+ INKWAF+GER+IHGNPSGVDNAVSTWGGALR+ QG +SSLK P
Sbjct: 181 KDGVSVSRWPEEDLKSINKWAFEGERVIHGNPSGVDNAVSTWGGALRFQQGTMSSLKSLP 240
Query: 229 ALQILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAP 288
+LQILLTNTKVPR+T+ALVA VR+RL KFPEIVAPLLTSIDAISLECERVLGEM AP P
Sbjct: 241 SLQILLTNTKVPRSTKALVAAVRSRLTKFPEIVAPLLTSIDAISLECERVLGEMVAAPVP 300
Query: 289 EQYLVLEELIDMNQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGL 348
EQYLVLEELIDMNQHHLNALGVGH SLDQLCQVT A GLHSKLTGAGGGGCGITLLKPGL
Sbjct: 301 EQYLVLEELIDMNQHHLNALGVGHNSLDQLCQVTAAHGLHSKLTGAGGGGCGITLLKPGL 360
Query: 349 EQPEVEATKQALTSCGFDCLETSIGAPGVSIHSATSLDSRVQQAL 393
EQ VEA KQALTSCGFDC ETSIGAPGVS HSA ++ V+QAL
Sbjct: 361 EQATVEAAKQALTSCGFDCWETSIGAPGVSTHSAAAVGDPVRQAL 405
>ref|XP_001911734.1| unnamed protein product [Podospora anserina]
emb|CAP73562.1| unnamed protein product [Podospora anserina]
Length = 528
Score = 367 bits (942), Expect = e-100, Method: Composition-based stats.
Identities = 135/405 (33%), Positives = 208/405 (51%), Gaps = 24/405 (5%)
Query: 2 LSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGK--VDLSLPNIGIK 59
+ +VSAPGKVI+ GEHAVVHGK A+A S+ LR++L + S + V L P+I
Sbjct: 73 MMPSFMVSAPGKVIVFGEHAVVHGKAAIAASIALRSYLLVTSLSKSRKTVTLKFPDIDFD 132
Query: 60 RAWDVARLQSL-----DTSFLEQGDVTTPTSEQVEKLKEVAGL-----PDDCAVTERLAV 109
+W + L VT E V ++ P D + +
Sbjct: 133 HSWRIDELPWAIFQQPSKKKYYYSLVTEIDQELVAAIQPYLADVSPDKPADVRKVHQNSA 192
Query: 110 LAFLYLYLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLK 169
+FLY++LS+ + + P+ + S +P GAGLGSSA +VCL+AALL + P
Sbjct: 193 GSFLYMFLSLGSQ--SFPACQYTLRSTIPIGAGLGSSATIAVCLSAALLLQLRTLSGPHP 250
Query: 170 DGDCVNRWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGK------ISS 223
D + +E IN+WA+ E IHGNPSGVDN VST G A+ + + +
Sbjct: 251 DQPP--EEARMQIERINRWAYVYEMFIHGNPSGVDNTVSTQGKAVMFQRTDYSKAPDVKP 308
Query: 224 LKRSPALQILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMG 283
L P L +LL +T+ P++T VA V P++V +L +ID ++ ++ E
Sbjct: 309 LWDFPELPLLLVDTRTPKSTAHEVAKVGRLKDTHPKLVGSILDAIDKVTQTSAELIAEDD 368
Query: 284 EAPAPEQ-YLVLEELIDMNQHHLNALGVGHASLDQLCQVTRARGLH-SKLTGAGGGGCGI 341
+ E + EL+++N L +LGV H L+++ ++ +G+ +KLTGAGGGGC I
Sbjct: 369 FSTEKEDSLRRVGELMNINHGLLVSLGVSHPRLERVRELVDHQGIGWTKLTGAGGGGCSI 428
Query: 342 TLLKPGLEQPEVEATKQALTSCGFDCLETSIGAPGVSIHSATSLD 386
TLLKPG+ + ++ ++ L G+ ET++G GV + L
Sbjct: 429 TLLKPGVPREKLARLEEQLDEEGYQRFETTLGGDGVGVLWPAVLK 473
>ref|XP_001229023.1| hypothetical protein CHGG_02507 [Chaetomium globosum CBS 148.51]
gb|EAQ90572.1| hypothetical protein CHGG_02507 [Chaetomium globosum CBS 148.51]
Length = 532
Score = 364 bits (935), Expect = 6e-99, Method: Composition-based stats.
Identities = 134/405 (33%), Positives = 206/405 (50%), Gaps = 24/405 (5%)
Query: 2 LSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGK--VDLSLPNIGIK 59
+ +VSAPGKVI+ GEH+VVHGK A+A +++LR++L + S K V L P+I
Sbjct: 82 MMPAFMVSAPGKVIVFGEHSVVHGKAAIAAAISLRSYLLVTTLSKSKRTVTLKFPDIDFD 141
Query: 60 RAWDVARLQSL-----DTSFLEQGDVTTPTSEQVEKLKEVAGL-----PDDCAVTERLAV 109
W++ L VT E V ++ P + +
Sbjct: 142 HCWNIDELPWATFQQPSKKKYYYSLVTELDPELVAAIQPFLANVSPDKPAGIRKVHQNSA 201
Query: 110 LAFLYLYLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLK 169
+FLY++LS+ + + P + S +P GAGLGSSA +VC++AALL + P
Sbjct: 202 GSFLYMFLSLGSQ--SFPGCQYTLRSTIPIGAGLGSSATIAVCMSAALLLQLRTLAGPHP 259
Query: 170 DGDCVNRWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGK------ISS 223
D + +E IN+WA+ E IHGNPSGVDN V+T G A+ + + +
Sbjct: 260 DQPADE--ARMQIERINRWAYVYEMFIHGNPSGVDNTVATQGKAVVFQRTDYGKPPSVRP 317
Query: 224 LKRSPALQILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVL-GEM 282
L P L +LL +T+VP++T VA V P +V +L ++D ++ VL E
Sbjct: 318 LWDFPELPLLLVDTRVPKSTAHEVAKVGKLKNTHPVLVGSILDAMDKVADASAEVLTEEG 377
Query: 283 GEAPAPEQYLVLEELIDMNQHHLNALGVGHASLDQLCQVTRARGLH-SKLTGAGGGGCGI 341
+ + + EL+ +N L +LGV H L+++ ++ G+ +KLTGAGGGGC I
Sbjct: 378 FDTQSEASLARVGELMTVNHGLLVSLGVSHPRLERVRELVDHEGIGWTKLTGAGGGGCCI 437
Query: 342 TLLKPGLEQPEVEATKQALTSCGFDCLETSIGAPGVSIHSATSLD 386
TLLKPG+E+ ++ + L GF+ ET++G GV + L
Sbjct: 438 TLLKPGVERKKLRKLQAQLDEEGFEKFETTLGGDGVGVLWPAVLK 482
>ref|XP_386088.1| hypothetical protein FG05912.1 [Gibberella zeae PH-1]
Length = 508
Score = 362 bits (929), Expect = 3e-98, Method: Composition-based stats.
Identities = 130/405 (32%), Positives = 208/405 (51%), Gaps = 24/405 (5%)
Query: 2 LSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGK--VDLSLPNIGIK 59
++ +VSAPGKVI+ GEH+VVHGK A+A +++LR++L + S K V L +IG+
Sbjct: 57 MAPPFMVSAPGKVIVFGEHSVVHGKAAIAAAISLRSYLHVTTLSKSKRTVSLRFADIGLV 116
Query: 60 RAWDVARLQS-----LDTSFLEQGDVTTPTSEQVEKLKE-----VAGLPDDCAVTERLAV 109
W++ L VT + V ++ P++ +V
Sbjct: 117 HTWNIEDLPWEAFQQPSKKKSYYSLVTELDPDLVAAIQPHIEVVSPNHPEEIRRVHHSSV 176
Query: 110 LAFLYLYLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLK 169
AFLYL+LS+ + P + S +P GAGLGSSA+ SVCLA+ALL + P
Sbjct: 177 SAFLYLFLSLGS--PSFPPCLYTLRSTIPIGAGLGSSASVSVCLASALLLQLRTLSGPHP 234
Query: 170 DGDCVNRWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGK------ISS 223
D + +E IN+WAF E IHGNPSGVDN V+T G A+ + + +
Sbjct: 235 DQPADE--ARLQVERINRWAFVSEMCIHGNPSGVDNTVATQGKAVVFQRTDYSKPPNVRP 292
Query: 224 LKRSPALQILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMG 283
L P L +LL +T+ ++T VA V P++V +L ++D ++ ++ E
Sbjct: 293 LWDFPELPLLLVDTRQAKSTAHEVAKVAKLKQTHPKLVNSILDAMDKVTDAASELIEETS 352
Query: 284 -EAPAPEQYLVLEELIDMNQHHLNALGVGHASLDQLCQVTRARGLH-SKLTGAGGGGCGI 341
+ + E + EL+ +N L +LGV H L+++ ++ G+ +KLTGAGGGGC I
Sbjct: 353 FDNGSVEDLSKVGELMTINHGLLVSLGVSHPRLERVRELVDHEGIGWTKLTGAGGGGCSI 412
Query: 342 TLLKPGLEQPEVEATKQALTSCGFDCLETSIGAPGVSIHSATSLD 386
TLL+P + +++ ++ L + + ET++G G+ + L
Sbjct: 413 TLLRPDVPAEKLQKLEERLETENYAKFETTLGGDGIGVLWPAVLK 457
>ref|XP_961360.1| hypothetical protein NCU03633 [Neurospora crassa OR74A]
emb|CAC28692.1| related to MEVALONATE KINASE [Neurospora crassa]
gb|EAA32124.1| hypothetical protein NCU03633 [Neurospora crassa OR74A]
Length = 528
Score = 359 bits (922), Expect = 2e-97, Method: Composition-based stats.
Identities = 137/405 (33%), Positives = 212/405 (52%), Gaps = 24/405 (5%)
Query: 2 LSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGK--VDLSLPNIGIK 59
+ +VSAPGKVI+ GEHAVVHGK A+A +++LR++L + S K V L P+I
Sbjct: 76 MMPTFMVSAPGKVIVFGEHAVVHGKAAIAAAISLRSYLLVNTLSKSKRTVTLKFPDIDFN 135
Query: 60 RAWDVARLQS-----LDTSFLEQGDVTTPTSEQVEKLKEVAGL-----PDDCAVTERLAV 109
+W++ L VT E V+ ++ P D + +
Sbjct: 136 HSWNIDELPWKIFQQPGKKKYYYSLVTEIDQELVDAVQPFLADVSIDKPADIRKVHQNSA 195
Query: 110 LAFLYLYLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLK 169
+FLY++LS+ + + P + S +P GAGLGSSA +VCL+AALL + P
Sbjct: 196 GSFLYMFLSLGSQ--SFPGCQYTLRSTIPIGAGLGSSATIAVCLSAALLLQLRTLSGPHP 253
Query: 170 DGDCVNRWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGK------ISS 223
D + +E IN+WAF E IHGNPSGVDN VST G A+ + + +
Sbjct: 254 DQPP--EEARLQIERINRWAFVYEMFIHGNPSGVDNTVSTQGKAVVFQRTDYNQPPSVRP 311
Query: 224 LKRSPALQILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMG 283
L P L +LL +T+ ++T VA V K P++V +LT+ID ++ +++ E G
Sbjct: 312 LWDFPKLPLLLVDTRTAKSTAHEVAKVATLKKKHPQLVGTILTAIDQVTQSSAQLIEEQG 371
Query: 284 -EAPAPEQYLVLEELIDMNQHHLNALGVGHASLDQLCQVTRARGLH-SKLTGAGGGGCGI 341
E + E++ +N L +LGV H L+++ ++ G+ +KLTGAGGGGC I
Sbjct: 372 FNTEDEESLSKVGEMMTINHGLLVSLGVSHPRLERVRELVDHEGIGWTKLTGAGGGGCSI 431
Query: 342 TLLKPGLEQPEVEATKQALTSCGFDCLETSIGAPGVSIHSATSLD 386
TLL+PG+ + +++ +Q L G+ ET++G+ GV + L
Sbjct: 432 TLLRPGVPREKLDKLEQRLDEEGYSKFETTLGSDGVGVLWPAVLK 476
>ref|XP_001593159.1| hypothetical protein SS1G_06081 [Sclerotinia sclerotiorum 1980]
gb|EDO03600.1| hypothetical protein SS1G_06081 [Sclerotinia sclerotiorum 1980]
Length = 473
Score = 358 bits (920), Expect = 4e-97, Method: Composition-based stats.
Identities = 138/404 (34%), Positives = 207/404 (51%), Gaps = 23/404 (5%)
Query: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGK--VDLSLPNIGI 58
M+ +VSAPGKVI+ GEHAVVHGK A+A +++LR++L + S K + L P+I +
Sbjct: 26 MMPP-FMVSAPGKVIVFGEHAVVHGKPAIAAAISLRSYLLVTALSKSKRTISLRFPDINL 84
Query: 59 KRAWDVARLQS-----LDTSFLEQGDVTTPTSEQVEKLKEVAGL--PDD---CAVTERLA 108
W++ L VT+ E V +K PD+ + +
Sbjct: 85 SHTWNIDDLPWSTFSHPSKKKYYYDQVTSLDPELVAAMKPHLENISPDESPSIRKIHQSS 144
Query: 109 VLAFLYLYLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPL 168
+FLY++LS+ + + P + S +P GAGLGSSA+ SVCL++ALL + P
Sbjct: 145 ASSFLYIFLSLGSQ--SFPGCLYTLRSTIPIGAGLGSSASISVCLSSALLLQIRTLSGPH 202
Query: 169 KDGDCVNRWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQG----KISSL 224
D LE IN+WAF GE IHGNPSGVDN VST G A+ Y + + L
Sbjct: 203 PDQPSNEAS--LQLERINRWAFVGEMCIHGNPSGVDNTVSTQGKAVIYQKFPEGPTVKPL 260
Query: 225 KRSPALQILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMG- 283
+ P L +LL +T+ ++T VA V K P IV +L +ID + ++ +
Sbjct: 261 RDFPELPLLLVDTQQAKSTAHEVAKVGLLKEKHPAIVDSILDAIDMVGQSAAAMISDPNY 320
Query: 284 EAPAPEQYLVLEELIDMNQHHLNALGVGHASLDQLCQVTRARGLH-SKLTGAGGGGCGIT 342
++ E L +L+ +N L +LGV H L+++ ++ G+ +KLTGAGGGGC IT
Sbjct: 321 DSENIECVESLGKLMTINHGLLVSLGVSHPRLERIRELVDHEGIGWTKLTGAGGGGCSIT 380
Query: 343 LLKPGLEQPEVEATKQALTSCGFDCLETSIGAPGVSIHSATSLD 386
LLKP + + L + G+ ET++G GV + +
Sbjct: 381 LLKPDTTPERMARLEATLENEGYKKFETTLGCDGVGVLWPAVIR 424
>ref|XP_001214601.1| conserved hypothetical protein [Aspergillus terreus NIH2624]
gb|EAU34492.1| conserved hypothetical protein [Aspergillus terreus NIH2624]
Length = 541
Score = 355 bits (912), Expect = 3e-96, Method: Composition-based stats.
Identities = 140/405 (34%), Positives = 207/405 (51%), Gaps = 24/405 (5%)
Query: 2 LSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNG--KVDLSLPNIGIK 59
L+ +VSAPGKVI+ GEHAVVHGK A+A +++LR++L + + V L+ +IG+
Sbjct: 92 LAPTFMVSAPGKVIVFGEHAVVHGKAAMAAAISLRSYLLVTTLTKSQRTVTLNFRDIGLA 151
Query: 60 RAWDVARLQS-----LDTSFLEQGDVTTPTSEQVEKLKEVAG-----LPDDCAVTERLAV 109
W++ L VT+ E V+ ++ LP+D R +
Sbjct: 152 HTWNIDDLPWDVFHQPAKKKYYYDLVTSLDPELVDAIQPYVDQVSPDLPEDQRKIHRRSA 211
Query: 110 LAFLYLYLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLK 169
AFLYL LS+ Q P + S +P GAGLGSSA+ VCL+AALL + P
Sbjct: 212 SAFLYLLLSLGSPQH--PGAIYTLRSTIPIGAGLGSSASVCVCLSAALLLQIRTLAGPHP 269
Query: 170 DGDCVNRWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGK------ISS 223
D + +E IN+WAF GE HGNPSGVDN VS G A+ + + + S
Sbjct: 270 DQPPDE--AEVQIERINRWAFVGEMCTHGNPSGVDNTVSAGGKAVIFRRTDYSKPPSVRS 327
Query: 224 LKRSPALQILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMG 283
L P L +LL +T+ PR+T VA V + P + +L +ID ++L E +L
Sbjct: 328 LPTFPELPLLLVDTRQPRSTAVEVAKVGKLKEEHPVVTESILDAIDKLTLSAEELLDGCE 387
Query: 284 EAPAPEQ-YLVLEELIDMNQHHLNALGVGHASLDQLCQVTRARGLH-SKLTGAGGGGCGI 341
+ E+ L L+ +N L +LGV H L+++ ++ + +KLTGAGGGGC I
Sbjct: 388 KTGVTEEVLERLGTLVRINHGFLVSLGVSHPRLERIRELVDFANIGWTKLTGAGGGGCAI 447
Query: 342 TLLKPGLEQPEVEATKQALTSCGFDCLETSIGAPGVSIHSATSLD 386
TLL+P ++ V + L + GF ET++G G+ + L
Sbjct: 448 TLLRPDADKNAVRDLEAKLAAEGFAKYETTLGGDGIGVLWPAVLR 492
>ref|XP_661473.1| hypothetical protein AN3869.2 [Aspergillus nidulans FGSC A4]
gb|EAA59134.1| hypothetical protein AN3869.2 [Aspergillus nidulans FGSC A4]
Length = 735
Score = 355 bits (912), Expect = 3e-96, Method: Composition-based stats.
Identities = 138/405 (34%), Positives = 207/405 (51%), Gaps = 24/405 (5%)
Query: 2 LSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNG--KVDLSLPNIGIK 59
L+ +VSAPGKVI++GEHAVVHGK A+A +++LR++L + S + L+ + +
Sbjct: 287 LAPAFMVSAPGKVIVYGEHAVVHGKAAMAAAISLRSYLLVTTLSKSQRTITLNFRDTNLN 346
Query: 60 RAWDVARLQS-----LDTSFLEQGDVTTPTSEQVEKLKEVA-----GLPDDCAVTERLAV 109
WD+ +L VTT E + ++ P++ + +
Sbjct: 347 HTWDIDQLPWDLFHHPSKKKYYYDLVTTLDQELYDAIQPHVEDISPDAPEEMRKIHKRSA 406
Query: 110 LAFLYLYLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLK 169
AFLYL+LS+ Q A + S +P GAGLGSSA+ VC++AALL + P
Sbjct: 407 SAFLYLFLSLGSPQSA--GAIYTLRSTIPIGAGLGSSASVCVCMSAALLVQIRTLAGPHP 464
Query: 170 DGDCVNRWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGK------ISS 223
D + +E IN+WAF GE IHGNPSGVDN VS G A+ + +G ++S
Sbjct: 465 DQPPDE--AEVQIERINRWAFVGEMCIHGNPSGVDNTVSAGGKAVIFRRGDYSKPPSVTS 522
Query: 224 LKRSPALQILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMG 283
L P L +LL +T+ R+T VA V ++P + +L +ID ++ E+V+ E
Sbjct: 523 LPTFPELPLLLVDTRQGRSTAVEVAKVGALRKEWPVVTESILDAIDNVTASAEKVIREPN 582
Query: 284 -EAPAPEQYLVLEELIDMNQHHLNALGVGHASLDQLCQVTRARGLH-SKLTGAGGGGCGI 341
E + + L LI +N L +LGV H L+++ ++ + +KLTGAGGGGC I
Sbjct: 583 PEGLSEKTLQQLGTLIRINHGFLVSLGVSHPRLERIRELVDYADIGWTKLTGAGGGGCAI 642
Query: 342 TLLKPGLEQPEVEATKQALTSCGFDCLETSIGAPGVSIHSATSLD 386
TLL+P L + K L F ET++G GV + L
Sbjct: 643 TLLRPDLNDDSLRQLKSQLQDENFGIYETTLGGDGVGVLWPAVLR 687
>ref|XP_001821298.1| hypothetical protein [Aspergillus oryzae RIB40]
dbj|BAE59296.1| unnamed protein product [Aspergillus oryzae]
Length = 534
Score = 355 bits (911), Expect = 4e-96, Method: Composition-based stats.
Identities = 131/405 (32%), Positives = 207/405 (51%), Gaps = 24/405 (5%)
Query: 2 LSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNG--KVDLSLPNIGIK 59
++ +VSAPGKVI+ GEHAVVHGK A+A +++LR++L + + + L+ +IG+
Sbjct: 86 MAPAFMVSAPGKVIVFGEHAVVHGKAAMAAAISLRSYLLVTTLTKSQRTITLNFRDIGLN 145
Query: 60 RAWDVARLQS-----LDTSFLEQGDVTTPTSEQVEKLKEVA-----GLPDDCAVTERLAV 109
W + L VT+ E ++ + + LP+D +R A
Sbjct: 146 HTWSIDELPWDLFHQPTKKKYYYDLVTSIDPELLDAILPLVERISPDLPEDKRKHQRGAA 205
Query: 110 LAFLYLYLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLK 169
AFLYL+ ++ Q P + S +P GAGLGSSA+ VC++AALL + P
Sbjct: 206 TAFLYLFCALGSPQH--PGAIYTLRSTIPTGAGLGSSASICVCISAALLLQIRTLAGPHP 263
Query: 170 DGDCVNRWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGK------ISS 223
D + +E IN+WAF GE IHGNPSGVDN V+ G A+ + +G +SS
Sbjct: 264 DQPPDE--AEVQIERINRWAFVGEMCIHGNPSGVDNTVAAGGKAVIFRRGDYSKPPAVSS 321
Query: 224 LKRSPALQILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMG 283
L P L +LL +T+ R+T VA V + P + +L +I+ ++ + ++ E
Sbjct: 322 LPNFPELPLLLVDTRQSRSTAVEVAKVGQLKEEQPLVTEAILDTIEKVNASAQEIIRETD 381
Query: 284 EAPAPEQ-YLVLEELIDMNQHHLNALGVGHASLDQLCQVTRARGLH-SKLTGAGGGGCGI 341
+ + + LI +N L +LGV H L+++ ++ + +KLTGAGGGGC I
Sbjct: 382 SSGISKDTLERIGALIRINHGLLVSLGVSHPRLERIRELVDFANIGWTKLTGAGGGGCAI 441
Query: 342 TLLKPGLEQPEVEATKQALTSCGFDCLETSIGAPGVSIHSATSLD 386
TLL+P + + ++ L GF ET++G GV + +
Sbjct: 442 TLLRPDADPSAIRQLEEKLDEEGFAKYETTLGGDGVGVLWPAVVR 486
>gb|EEH48028.1| mevalonate kinase [Paracoccidioides brasiliensis Pb18]
Length = 490
Score = 354 bits (909), Expect = 6e-96, Method: Composition-based stats.
Identities = 133/405 (32%), Positives = 203/405 (50%), Gaps = 24/405 (5%)
Query: 2 LSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNG--KVDLSLPNIGIK 59
++ +VSAPGKVI+ GEHAVVHGK A+A +++LR++L + S + L+ +I +
Sbjct: 38 MAPAFMVSAPGKVIVFGEHAVVHGKRAMAAAISLRSYLLVTTLSKSQRTITLNFRDIELD 97
Query: 60 RAWDVARLQSL-----DTSFLEQGDVTTPTSEQVEKLKE-----VAGLPDDCAVTERLAV 109
W++ L VT+ E +E ++ G PD+ R +
Sbjct: 98 HTWNIDSLPWALFCQPSKKKFYYDSVTSLDPELLEAIQPHIADISIGKPDEVRKIHRSSA 157
Query: 110 LAFLYLYLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLK 169
AFLYL+LS+ + + S +P GAGLGSSA+ +VCL+AALL + P +
Sbjct: 158 TAFLYLFLSLSS--PDSHAAIYTLRSTIPIGAGLGSSASIAVCLSAALLLQIRILAGPHQ 215
Query: 170 DGDCVNRWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGK------ISS 223
D + +E IN+WAF GE IHGNPSGVDN VS G A+ + +G ++
Sbjct: 216 DQPP--EEAEVQIERINRWAFVGEMCIHGNPSGVDNTVSAGGKAVIFRRGDYSKPPSVTP 273
Query: 224 LKRSPALQILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMG 283
+ P L +LL N++ PR+T VA V P + L +ID ++ +
Sbjct: 274 ILDFPELPLLLVNSRQPRSTATEVAKVGRFCKAHPAVAESTLAAIDQVTESANNFIQSGR 333
Query: 284 -EAPAPEQYLVLEELIDMNQHHLNALGVGHASLDQLCQVTRARGLH-SKLTGAGGGGCGI 341
+ + E EL +N L +LGV H L+++ ++ G+ +KLTGAGGGGC I
Sbjct: 334 FDKDSNEDIDHFGELFRINHGLLVSLGVSHPRLERIRELVDHAGIGWTKLTGAGGGGCAI 393
Query: 342 TLLKPGLEQPEVEATKQALTSCGFDCLETSIGAPGVSIHSATSLD 386
LL+ Q + +Q L GF+ ET++G G+ + L
Sbjct: 394 VLLRANTNQAVLHHLEQNLDDEGFERYETTLGGNGIGVLWPAVLK 438
>ref|XP_752047.1| mevalonate kinase [Aspergillus fumigatus Af293]
gb|EAL90009.1| mevalonate kinase [Aspergillus fumigatus Af293]
Length = 538
Score = 353 bits (907), Expect = 1e-95, Method: Composition-based stats.
Identities = 135/405 (33%), Positives = 210/405 (51%), Gaps = 24/405 (5%)
Query: 2 LSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNG--KVDLSLPNIGIK 59
++ +VSAPGKVI++GEHAVVHGK A+A +++LR++L + S + ++ +IG+
Sbjct: 88 MAPAFMVSAPGKVIVYGEHAVVHGKAAMAAAISLRSYLLVTTLSKSQRTITMNFRDIGLD 147
Query: 60 RAWDVARLQS-----LDTSFLEQGDVTTPTSEQVEKLKEVAGL-----PDDCAVTERLAV 109
W++ L VT+ E V ++ A P+D R +
Sbjct: 148 HTWNIDELPWDVFHHPSKKKFYYDLVTSLDPELVAAIQPHADAVSPDKPEDVRKIHRRSA 207
Query: 110 LAFLYLYLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLK 169
AFLYL+LS+ Q P + S +P GAGLGSSA+ VCL+AALL + P
Sbjct: 208 SAFLYLFLSLGSSQN--PGAIYTLRSTIPIGAGLGSSASVCVCLSAALLLQIRTLAGPHP 265
Query: 170 DGDCVNRWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGK------ISS 223
D + +E IN+WAF GE HGNPSGVDN VS G A+ + + ++
Sbjct: 266 DQPPDE--AEVQIERINRWAFVGEMCTHGNPSGVDNTVSAGGKAVVFRREDYSKPPTVTP 323
Query: 224 LKRSPALQILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMG 283
L P L +LL +T+ R+T VA V ++P + +L +ID ++L ++ + E+
Sbjct: 324 LLNFPELPLLLVDTRQSRSTAVEVAKVGKLKDEYPVVTDSILEAIDQVTLAAQQKIQEIS 383
Query: 284 EAPAP-EQYLVLEELIDMNQHHLNALGVGHASLDQLCQVTRARGLH-SKLTGAGGGGCGI 341
L LI +N L +LGV H L+++ ++ + +KLTGAGGGGC I
Sbjct: 384 TNGISYRTLEDLGTLIRINHGFLVSLGVSHPRLERIRELVDYADIGWTKLTGAGGGGCAI 443
Query: 342 TLLKPGLEQPEVEATKQALTSCGFDCLETSIGAPGVSIHSATSLD 386
TLL+P +++ V ++ L++ GF ET++G G+ + L
Sbjct: 444 TLLRPDIKEEAVRELEEKLSAEGFVKYETTLGGDGIGVLWPAVLR 488
>ref|XP_001267243.1| mevalonate kinase [Neosartorya fischeri NRRL 181]
gb|EAW25346.1| mevalonate kinase [Neosartorya fischeri NRRL 181]
Length = 538
Score = 353 bits (906), Expect = 1e-95, Method: Composition-based stats.
Identities = 136/405 (33%), Positives = 209/405 (51%), Gaps = 24/405 (5%)
Query: 2 LSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNG--KVDLSLPNIGIK 59
++ +VSAPGKVI++GEHAVVHGK A+A +++LR++L + S + ++ +IG+
Sbjct: 88 MAPAFMVSAPGKVIVYGEHAVVHGKAAMAAAISLRSYLLVTTLSKSQRTITMNFRDIGLD 147
Query: 60 RAWDVARLQS-----LDTSFLEQGDVTTPTSEQVEKLKEVAGL-----PDDCAVTERLAV 109
W++ L VT+ E V ++ A P+D R +
Sbjct: 148 HTWNIDELPWDVFHHPSKKKFYYDLVTSLDPELVAAIQPHADAVSPEKPEDVRKIHRRSA 207
Query: 110 LAFLYLYLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLK 169
AFLYL+LS+ Q P + S +P GAGLGSSA+ VCL+AALL + P
Sbjct: 208 SAFLYLFLSLGSSQN--PGAIYTLRSTIPIGAGLGSSASVCVCLSAALLLQIRTLAGPHP 265
Query: 170 DGDCVNRWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGK------ISS 223
D + +E IN+WAF GE HGNPSGVDN VS G A+ + + ++
Sbjct: 266 DQPPDE--AEVQIERINRWAFVGEMCTHGNPSGVDNTVSAGGKAVVFRREDYSKPPTVTP 323
Query: 224 LKRSPALQILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMG 283
L P L +LL +T+ R+T VA V + P + +L +ID ++L ++ + E+
Sbjct: 324 LLNFPELPLLLVDTRQSRSTAVEVAKVGKLKDEHPVVADSILEAIDQVTLAAQQKIQEIS 383
Query: 284 EAPAPEQ-YLVLEELIDMNQHHLNALGVGHASLDQLCQVTRARGLH-SKLTGAGGGGCGI 341
E+ L LI +N L +LGV H L+++ ++ + +KLTGAGGGGC I
Sbjct: 384 TNGISERTLEDLGTLIRINHGFLVSLGVSHPRLERIRELVDYADIGWTKLTGAGGGGCAI 443
Query: 342 TLLKPGLEQPEVEATKQALTSCGFDCLETSIGAPGVSIHSATSLD 386
TLL+P ++ V ++ L + GF ET++G G+ + L
Sbjct: 444 TLLRPDTKEEAVRELEEKLNAEGFVKYETTLGGDGIGVLWPAVLR 488
>gb|EDP50156.1| mevalonate kinase [Aspergillus fumigatus A1163]
Length = 538
Score = 352 bits (904), Expect = 2e-95, Method: Composition-based stats.
Identities = 135/405 (33%), Positives = 210/405 (51%), Gaps = 24/405 (5%)
Query: 2 LSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNG--KVDLSLPNIGIK 59
++ +VSAPGKVI++GEHAVVHGK A+A +++LR++L + S + ++ +IG+
Sbjct: 88 MAPAFMVSAPGKVIVYGEHAVVHGKAAMAAAISLRSYLLVTTLSKSQRTITMNFRDIGLD 147
Query: 60 RAWDVARLQS-----LDTSFLEQGDVTTPTSEQVEKLKEVAGL-----PDDCAVTERLAV 109
W++ L VT+ E V ++ A P+D R +
Sbjct: 148 HTWNIDELPWDVFHHPSKKKFYYDLVTSLDPELVAAIQPHADAVSPDKPEDVRKIHRRSA 207
Query: 110 LAFLYLYLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLK 169
AFLYL+LS+ Q P + S +P GAGLGSSA+ VCL+AALL + P
Sbjct: 208 SAFLYLFLSLGSSQN--PGAIYTLRSTIPIGAGLGSSASVCVCLSAALLLQIRTLAGPHP 265
Query: 170 DGDCVNRWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGK------ISS 223
D + +E IN+WAF GE HGNPSGVDN VS G A+ + + ++
Sbjct: 266 DQPPDE--AEVQIERINRWAFVGEMCTHGNPSGVDNTVSAGGKAVVFRREDYSKPPTVTP 323
Query: 224 LKRSPALQILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMG 283
L P L +LL +T+ R+T VA V ++P + +L +ID ++L ++ + E+
Sbjct: 324 LLNFPELPLLLVDTRQSRSTAVEVAKVGKLKDEYPVVTDSILEAIDQVTLAAQQKIQEIS 383
Query: 284 EAPAP-EQYLVLEELIDMNQHHLNALGVGHASLDQLCQVTRARGLH-SKLTGAGGGGCGI 341
L LI +N L +LGV H L+++ ++ + +KLTGAGGGGC I
Sbjct: 384 TNGISYRTLEDLGTLIRINHGFLVSLGVSHPRLERIRELVDYADIGWTKLTGAGGGGCAI 443
Query: 342 TLLKPGLEQPEVEATKQALTSCGFDCLETSIGAPGVSIHSATSLD 386
TLL+P +++ V ++ L++ GF ET++G G+ + L
Sbjct: 444 TLLRPDIKEEAVRELEEKLSAEGFVKYETTLGGDGIGVLWPAVLR 488
>ref|XP_001271672.1| mevalonate kinase [Aspergillus clavatus NRRL 1]
gb|EAW10246.1| mevalonate kinase [Aspergillus clavatus NRRL 1]
Length = 536
Score = 352 bits (904), Expect = 3e-95, Method: Composition-based stats.
Identities = 137/405 (33%), Positives = 208/405 (51%), Gaps = 24/405 (5%)
Query: 2 LSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNG--KVDLSLPNIGIK 59
++ +VSAPGKVI++GEHAVVHGK A+A +++LR++L + S V ++ +IG+
Sbjct: 85 MAPAFMVSAPGKVIVYGEHAVVHGKAAMAAAISLRSYLLVTTLSKSQRTVTMNFRDIGLD 144
Query: 60 RAWDVARLQS-----LDTSFLEQGDVTTPTSEQVEKLKEVAGL-----PDDCAVTERLAV 109
W++ L VT+ E V+ ++ P+D R +
Sbjct: 145 HTWNIDDLPWDVFHHPSKKKFYYNLVTSLDPELVDAIQPHVDAVSPDKPEDVRKIHRRSA 204
Query: 110 LAFLYLYLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLK 169
AFLYL+LS+ Q P + S +P GAGLGSSA+ VCL+AALL + P
Sbjct: 205 SAFLYLFLSLGSPQT--PGAIYTLRSTIPIGAGLGSSASVCVCLSAALLLQIRTLAGPHP 262
Query: 170 DGDCVNRWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKIS------S 223
D T+ E IN+WAF GE HGNPSGVDN VS G A+ + + +
Sbjct: 263 DQPPDEAETQI--ERINRWAFVGEMCTHGNPSGVDNTVSAGGKAVIFRREDYTKPPTVIP 320
Query: 224 LKRSPALQILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMG 283
L P L +LL +T+ R+T A VA V P + +L +ID ++L + + ++
Sbjct: 321 LPNFPELPLLLVDTRQARSTAAEVAKVGKLKDDHPVVTEAILDAIDKVTLAAQEAIQDIN 380
Query: 284 EAPAPEQ-YLVLEELIDMNQHHLNALGVGHASLDQLCQVTRARGLH-SKLTGAGGGGCGI 341
Q L LI +N L +LGV H L+++ ++ + +KLTGAGGGGC I
Sbjct: 381 SKGVSAQILEHLGTLIRINHGFLVSLGVSHPRLERIRELVDYANIGWTKLTGAGGGGCAI 440
Query: 342 TLLKPGLEQPEVEATKQALTSCGFDCLETSIGAPGVSIHSATSLD 386
T+L+P +++ V +Q L+ GF+ ET++G G+ + L
Sbjct: 441 TVLRPDVKEEAVRDLEQKLSVEGFEKYETTLGGDGIGVLWPAVLR 485
>ref|XP_001559870.1| hypothetical protein BC1G_01429 [Botryotinia fuckeliana B05.10]
gb|EDN27159.1| hypothetical protein BC1G_01429 [Botryotinia fuckeliana B05.10]
Length = 498
Score = 351 bits (901), Expect = 6e-95, Method: Composition-based stats.
Identities = 139/404 (34%), Positives = 211/404 (52%), Gaps = 23/404 (5%)
Query: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGK--VDLSLPNIGI 58
M+ +VSAPGKVI+ GEHAVVHGK A+A +++LR++L + S K + L P+I +
Sbjct: 50 MMPP-FMVSAPGKVIVFGEHAVVHGKPAIAAAISLRSYLLVTSLSKSKRTISLRFPDINL 108
Query: 59 KRAWDVARLQSLDTSFL-----EQGDVTTPTSEQVEKLKEVAGL--PDD---CAVTERLA 108
W++ L S +VT+ E V +K PD+ + +
Sbjct: 109 SHTWNIDDLPWSTFSHPSKKKHYYDEVTSLDPELVAAMKPHLENISPDESPAIRKIHQSS 168
Query: 109 VLAFLYLYLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPL 168
+FLY++LS+ + + P + S +P GAGLGSSA+ SVCL++ALL + P
Sbjct: 169 ASSFLYIFLSLGSQ--SFPGCLYTLRSTIPIGAGLGSSASISVCLSSALLLQIRTLSGPH 226
Query: 169 KDGDCVNRWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQG----KISSL 224
D LE IN+WAF GE IHGNPSGVDN VST G A+ Y + + L
Sbjct: 227 PDQPSNEAS--LQLERINRWAFVGEMCIHGNPSGVDNTVSTQGKAVIYQKSPDGPTVKPL 284
Query: 225 KRSPALQILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMG- 283
+ P L +LL +T+ ++T VA V K P IV +L +ID + ++ +
Sbjct: 285 RNFPELPLLLVDTQQAKSTAHEVAKVDLLKQKHPAIVDSILNAIDMVGQSAAVMISDPEY 344
Query: 284 EAPAPEQYLVLEELIDMNQHHLNALGVGHASLDQLCQVTRARGLH-SKLTGAGGGGCGIT 342
++ + L +L+ +N L +LGV H L+++ ++ G+ +KLTGAGGGGC IT
Sbjct: 345 DSEDLKCVEDLGKLMTVNHGLLVSLGVSHPRLERIRELVDHEGIGWTKLTGAGGGGCSIT 404
Query: 343 LLKPGLEQPEVEATKQALTSCGFDCLETSIGAPGVSIHSATSLD 386
LLKPG + ++ L + G+ ET++G GV + +
Sbjct: 405 LLKPGTTHDRMTRLEETLETEGYKKFETTLGCDGVGVLWPAVIK 448
>ref|XP_001241830.1| hypothetical protein CIMG_05726 [Coccidioides immitis RS]
gb|EAS30247.1| hypothetical protein CIMG_05726 [Coccidioides immitis RS]
Length = 612
Score = 350 bits (897), Expect = 2e-94, Method: Composition-based stats.
Identities = 133/405 (32%), Positives = 200/405 (49%), Gaps = 24/405 (5%)
Query: 2 LSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGK--VDLSLPNIGIK 59
++ +VSAPGKVI+ GEHAVVHGK A+A +++LR++L + S + V L+ + G+
Sbjct: 163 MAPPFMVSAPGKVIVFGEHAVVHGKKAMAAAISLRSYLLVTTLSKSRRTVTLNFRDTGLD 222
Query: 60 RAWDVARLQSL-----DTSFLEQGDVTTPTSEQVEKLKE-----VAGLPDDCAVTERLAV 109
WD+ L VT+ + ++ ++ P + + +
Sbjct: 223 HTWDIDSLPWDVFNHSSKKKFYYDRVTSLDPDLLDAIRPHISNVSPDKPPEVRKVHQGSA 282
Query: 110 LAFLYLYLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLK 169
AFLYLYLS+ Q + S +P GAGLGSSA+ VCL+AALL + P
Sbjct: 283 SAFLYLYLSLGSPQS--HGAIYTLRSTIPIGAGLGSSASVCVCLSAALLLQIRALAGPHP 340
Query: 170 DGDCVNRWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKIS------S 223
D + +E IN+WAF GE IHGNPSGVDN VS G A+ + +G S
Sbjct: 341 DQPFDES--EVQIERINRWAFVGELCIHGNPSGVDNTVSAGGKAVIFRRGDYSKPPTVIP 398
Query: 224 LKRSPALQILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLG-EM 282
+ P L +LL N++ R+T VA V P I LL ID ++ + E
Sbjct: 399 ILDFPELPLLLVNSRQSRSTATEVAKVGTLKKLHPAITDCLLDGIDQVTTSAHDFISSEN 458
Query: 283 GEAPAPEQYLVLEELIDMNQHHLNALGVGHASLDQLCQVTRARGLH-SKLTGAGGGGCGI 341
+ + E L +N L +LGV H L+++ ++ G+ +KLTGAGGGGC I
Sbjct: 459 FDKNSSETLNYFGTLFRINHGLLVSLGVSHPRLERIRELVDHTGIGWTKLTGAGGGGCAI 518
Query: 342 TLLKPGLEQPEVEATKQALTSCGFDCLETSIGAPGVSIHSATSLD 386
TL++ E ++ ++ L G++ ET++G GV + L
Sbjct: 519 TLIRTDRESTALKPLERQLDEEGYERYETTLGGQGVGVLWPAVLK 563
>ref|XP_001105689.1| PREDICTED: mevalonate kinase isoform 1 [Macaca mulatta]
Length = 344
Score = 349 bits (895), Expect = 3e-94, Method: Composition-based stats.
Identities = 330/396 (83%), Positives = 332/396 (83%), Gaps = 52/396 (13%)
Query: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 60
MLSEVLLVSAPGKVILHGEHAVVHGKVALAV+LNLRTFLRLQPHSNGKVDLSLPNIGIK
Sbjct: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVALNLRTFLRLQPHSNGKVDLSLPNIGIKW 60
Query: 61 AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC 120
AWDVARLQ LDTSFLEQGD TTPT E VEKLKEVAGLPDDCAVTE LAVLAFLYLYLSIC
Sbjct: 61 AWDVARLQLLDTSFLEQGDATTPTPELVEKLKEVAGLPDDCAVTESLAVLAFLYLYLSIC 120
Query: 121 RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE 180
RK RWTKE
Sbjct: 121 RK----------------------------------------------------QRWTKE 128
Query: 181 DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP 240
DLELINKWAFQGER+IHGNPSGVDNAVSTWGGALRY QGKISSLKR PALQILLTNTKVP
Sbjct: 129 DLELINKWAFQGERVIHGNPSGVDNAVSTWGGALRYQQGKISSLKRPPALQILLTNTKVP 188
Query: 241 RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM 300
RNTR LVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM
Sbjct: 189 RNTRTLVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM 248
Query: 301 NQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL 360
NQHHLNALGVGHASLDQLCQVTRA GLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL
Sbjct: 249 NQHHLNALGVGHASLDQLCQVTRAHGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL 308
Query: 361 TSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL 396
TSCGFDC ETSIGAPGVSIHSATSLDSRVQQALDGL
Sbjct: 309 TSCGFDCWETSIGAPGVSIHSATSLDSRVQQALDGL 344
>ref|XP_460851.1| hypothetical protein DEHA0F12188g [Debaryomyces hansenii CBS767]
emb|CAG89196.1| unnamed protein product [Debaryomyces hansenii CBS767]
Length = 433
Score = 346 bits (888), Expect = 2e-93, Method: Composition-based stats.
Identities = 133/409 (32%), Positives = 221/409 (54%), Gaps = 22/409 (5%)
Query: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSN-GKVDLSLPNIGIK 59
M LVSAPGKVI++GEH+ V+GK A+A +L+LR +L + P + + L P+IG+
Sbjct: 1 MSVSPFLVSAPGKVIIYGEHSAVYGKPAIAAALSLRAYLLVTPCEDVNDIRLDFPDIGLS 60
Query: 60 RAWDVARLQSLDTSFL------EQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFL 113
+W+ + D + E V+ L V + + A L FL
Sbjct: 61 HSWNKENIPWEDIRKFVTFKDEKPVVTEELVPEIVDLLSTVLADVE--SKLHYTACLCFL 118
Query: 114 YLYLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNP-LKDGD 172
YLY ++ + +P + +V S LP GAGLGSSA +VCLA+AL + + + +
Sbjct: 119 YLYANL--SNKDVPGMRFIVKSTLPIGAGLGSSACTAVCLASALARLGKHVSAACHTSTE 176
Query: 173 CVNRWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKI-------SSLK 225
V + DL+ I+ W+ GE+ HGNPSG+DNAV+T+GGA+ + + I ++++
Sbjct: 177 KVYKKENSDLDFIDSWSLMGEKCFHGNPSGIDNAVATYGGAVMFQRTTIPSKPSVRTTMR 236
Query: 226 RSPALQILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEA 285
P ++++L NTKVPR+T ALV V +P+ +L +++ + E +++ + +
Sbjct: 237 NFPPIKLILINTKVPRSTAALVGNVAQVNRTYPKCAGSILDAMEHLVFEAYQIM--IRPS 294
Query: 286 PAPEQYLVLEELIDMNQHHLNALGVGHASLDQLCQVTRARGLHS-KLTGAGGGGCGITLL 344
E+ L EL+++N L ALGV H +L+++ + G+ S KLTGAGGGGC I+L+
Sbjct: 295 FGKEEKDQLRELVNINHGLLVALGVSHPALEKIKIIGDTHGIGSTKLTGAGGGGCAISLV 354
Query: 345 KPGLEQPEVEATKQALTSCGFDCLETSIGAPGVSIHSATSLDSRVQQAL 393
+E+ ++ + + G++ ETS+G GV S +D + +
Sbjct: 355 HDDVEEEVIQKAIKEFENEGYETFETSLGGKGVGSLSLEDVDKDKRDTV 403
>ref|XP_001401587.1| hypothetical protein An04g02190 [Aspergillus niger]
emb|CAL00706.1| unnamed protein product [Aspergillus niger]
Length = 448
Score = 346 bits (887), Expect = 2e-93, Method: Composition-based stats.
Identities = 129/405 (31%), Positives = 201/405 (49%), Gaps = 24/405 (5%)
Query: 2 LSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNG--KVDLSLPNIGIK 59
++ +VSAPGKVI+ GEHAVVHGK A+A +++LR++ + S + L+L ++
Sbjct: 1 MAPPFMVSAPGKVIVFGEHAVVHGKAAMAAAISLRSYFLVTTLSKSQRTITLNLRDMDFN 60
Query: 60 RAWDVARLQS-----LDTSFLEQGDVTTPTSEQVEKLKEVAGL-----PDDCAVTERLAV 109
W++ L VT+ E + LK P++ + +
Sbjct: 61 HTWNIDDLPWDFFKQPSKKKYYYDLVTSLDEELYDSLKPCVEDISPKAPEEIRKKHKGSA 120
Query: 110 LAFLYLYLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLK 169
LAFLYL+ S+ Q P + S +P GAGLGSSA+ C +AALL + P
Sbjct: 121 LAFLYLFCSLGSPQH--PGAIYTLRSTIPMGAGLGSSASVCTCFSAALLLQIRTLAGPHD 178
Query: 170 DGDCVNRWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKIS------S 223
D + +E IN+WAF GE IHGNPSGVDN VST G A+ + + S
Sbjct: 179 DQPPDE--AELQIERINRWAFVGELCIHGNPSGVDNTVSTGGKAVIFRREDYSKPPKVIP 236
Query: 224 LKRSPALQILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEM- 282
L P L +LL +T+ R+T VA V + P + +L +ID +++ + + +
Sbjct: 237 LPNFPELPLLLVDTRQSRSTAVEVAKVGKLKKEHPLVTESILDAIDKVTVSAQSAIQGVE 296
Query: 283 GEAPAPEQYLVLEELIDMNQHHLNALGVGHASLDQLCQVTRARGLH-SKLTGAGGGGCGI 341
G++ E + L+ +N L +LGV H L+++ ++ + +KLTGAGGGGC I
Sbjct: 297 GDSIDKETLEHIGTLVRVNHGFLVSLGVSHPRLERIRELVDFANIGWTKLTGAGGGGCAI 356
Query: 342 TLLKPGLEQPEVEATKQALTSCGFDCLETSIGAPGVSIHSATSLD 386
TLL+P + ++ L + F ET++G G+ + L
Sbjct: 357 TLLRPDASVDALRELERKLAAENFSKYETTLGGDGIGVLWPAVLH 401
>ref|XP_790690.1| PREDICTED: similar to Mevalonate kinase (MK) [Strongylocentrotus
purpuratus]
ref|XP_001200159.1| PREDICTED: similar to Mevalonate kinase (MK) [Strongylocentrotus
purpuratus]
Length = 413
Score = 345 bits (886), Expect = 3e-93, Method: Composition-based stats.
Identities = 178/383 (46%), Positives = 246/383 (64%), Gaps = 6/383 (1%)
Query: 5 VLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKRAWDV 64
+ +SAPGK+ILHGEHAVVHGK ALA LNLR++L L+ +G++ L+LP+I ++R+WDV
Sbjct: 15 SIFISAPGKIILHGEHAVVHGKTALAAGLNLRSYLCLKEKDSGRLHLNLPDIDLERSWDV 74
Query: 65 ARLQSLDTSFLEQGDV-TTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSICRKQ 123
LQ L + P+ E +++L+ G D T+RLAV+AFLYLYL I +
Sbjct: 75 LELQEQFRDLLNSDVMEVKPSVEIMQRLRLFLGY-SDTETTKRLAVMAFLYLYLCIAGRN 133
Query: 124 RALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKEDLE 183
P LD +V S LPPGAGLGSSAA+SVCLAA LLT + I PL D W++ED+E
Sbjct: 134 GKFPILDTLVSSALPPGAGLGSSAAFSVCLAAGLLTWAKAI-IPLSLSDNTLDWSREDME 192
Query: 184 LINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVPRNT 243
LIN WA++GER+IHGNPSG+DN++S GGA+ Y Q I+ L+ P L ILL NT V R+T
Sbjct: 193 LINTWAYEGERVIHGNPSGIDNSISVHGGAIEYRQKVITPLENMPELSILLVNTCVARST 252
Query: 244 RALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEA---PAPEQYLVLEELIDM 300
+ LVAGV+ R K+P++ P+L SI+ IS EC+R L + + L EL+D+
Sbjct: 253 KELVAGVQRRHDKYPKVYGPILDSIEEISQECKRTLQALKTGESLDKDGAFKSLGELVDI 312
Query: 301 NQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL 360
NQ L +GV H +++ + + A +H+KLTGAGGGGC LL P + + V+A + L
Sbjct: 313 NQQLLYVIGVSHPAINNIVRSAAAYKIHAKLTGAGGGGCVFALLPPDIPKDSVKALQADL 372
Query: 361 TSCGFDCLETSIGAPGVSIHSAT 383
++ TS+GA GV +H +
Sbjct: 373 FRHNYESWITSLGAHGVMMHRSK 395
>ref|XP_723495.1| mevalonate kinase [Candida albicans SC5314]
ref|XP_723305.1| mevalonate kinase [Candida albicans SC5314]
gb|EAL04601.1| hypothetical protein CaO19.12272 [Candida albicans SC5314]
gb|EAL04797.1| hypothetical protein CaO19.4809 [Candida albicans SC5314]
Length = 431
Score = 344 bits (882), Expect = 8e-93, Method: Composition-based stats.
Identities = 145/407 (35%), Positives = 222/407 (54%), Gaps = 23/407 (5%)
Query: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSN-GKVDLSLPNIGIK 59
M +V APGKVI+ GEHA V+GK A+A +L+LR +L + P S+ + L P+I +
Sbjct: 1 MSQLPFIVGAPGKVIIFGEHAAVYGKPAIAAALSLRCYLLVSPSSDSNTIRLQFPDIKLD 60
Query: 60 RAWDVARLQSLDTSFLEQGD-------VTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAF 112
+W++ L + D + E V+KL D A F
Sbjct: 61 HSWNIKDLPWEEIKPYLTYDSANKPQIPSELVPEIVDKLSSFLNGFD--NKMHYYACFCF 118
Query: 113 LYLYLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNP-LKDG 171
LYL +++C + ++ +V S LP GAGLGSSA+ SVCL++AL + I P L +
Sbjct: 119 LYLLMNLC--DSKVSGMNFIVRSTLPIGAGLGSSASTSVCLSSALALMGGWINKPSLHEN 176
Query: 172 DCVNRWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKI-------SSL 224
D ++ DLE I+KW+ GE+ HGNPSG+DNAV+T+GGA+ + + +++
Sbjct: 177 DKLDTADIPDLEFIDKWSLIGEKCFHGNPSGIDNAVATFGGAVMFQRTSTPEQPSIRTNM 236
Query: 225 KRSPALQILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGE 284
+ PA+++LLTNTKVP++T LVAGV +F I +LT+I+ +S E +V+ M
Sbjct: 237 RNFPAIKLLLTNTKVPKSTADLVAGVGRLNAEFNSISTSILTAIEHLSQEAYKVM--MNP 294
Query: 285 APAPEQYLVLEELIDMNQHHLNALGVGHASLDQLCQVTRARGLHS-KLTGAGGGGCGITL 343
E+ VL +L+++N L ALGV H +L+ + + + + KLTGAGGGGC ITL
Sbjct: 295 MFGKEETNVLRKLVNINHGLLVALGVSHPALETVKIIGDKHRIGATKLTGAGGGGCAITL 354
Query: 344 LKPGLEQPEVEATKQALTSCGFDCLETSIGAPGVSIHSATSLDSRVQ 390
+ +E+ + + G++ ETS+G GV I LD +
Sbjct: 355 VNDDVEESVIHNAIKEFEDSGYESFETSLGGKGVGILFHEDLDDATK 401
>ref|XP_001527900.1| hypothetical protein LELG_00420 [Lodderomyces elongisporus NRRL
YB-4239]
gb|EDK42242.1| hypothetical protein LELG_00420 [Lodderomyces elongisporus NRRL
YB-4239]
Length = 439
Score = 339 bits (869), Expect = 3e-91, Method: Composition-based stats.
Identities = 146/393 (37%), Positives = 219/393 (55%), Gaps = 24/393 (6%)
Query: 6 LLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGK--VDLSLPNIGIKRAWD 63
+VSAPGKVI+ GEHA V+GK A+A +L+LR FL + P + V L P+IG+ +WD
Sbjct: 11 FVVSAPGKVIIFGEHAAVYGKPAIAAALSLRCFLLVTPSTGDSNMVRLKFPDIGLDHSWD 70
Query: 64 VARLQSLDT-------SFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLY 116
++ + S + E V+ L + DD +A FLYLY
Sbjct: 71 ISSIPWETIKAKVKADSNGKPQPPAELDPEIVDSLSPLLRNLDDN--VHYIACFCFLYLY 128
Query: 117 LSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNP-LKDGDCVN 175
++C + L VV S LP GAGLGSSA+ +VCL+AAL + I +P L + D V
Sbjct: 129 TNLCSQ--DLQGYTFVVRSTLPIGAGLGSSASTAVCLSAALSKLGNWIKDPKLSNHDHVL 186
Query: 176 RWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQ-------GKISSLKRSP 228
+L+ I+ W+ GE+ HGNPSG+DNAV+T GGA++Y + SS++ P
Sbjct: 187 ESEIPELDFIDNWSLIGEKCFHGNPSGIDNAVATHGGAVKYQRILNSTKSSLRSSIRDFP 246
Query: 229 ALQILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAP 288
+++LLTNTKVP++T LVAGV +FP+I P+L +++ IS + V+
Sbjct: 247 PIKLLLTNTKVPKSTAKLVAGVGELTKEFPDITNPILNAVEFISEQAYEVMHLPQ--FGK 304
Query: 289 EQYLVLEELIDMNQHHLNALGVGHASLDQLCQVTRARGLHS-KLTGAGGGGCGITLLKPG 347
++ L +L++MN L ALGV H +L+ + ++ L + KLTGAGGGGC ITL+
Sbjct: 305 QETATLRKLVNMNHGLLVALGVSHPALETVKIISDKYNLGATKLTGAGGGGCAITLVDES 364
Query: 348 LEQPEVEATKQALTSCGFDCLETSIGAPGVSIH 380
+++ + + + GF+ ETS+G GV +
Sbjct: 365 IDKSVIHNAMKEYENEGFESFETSLGGKGVGML 397
>emb|CAM15186.1| novel protein similar to vertebrate mevalonate kinase (mevalonic
aciduria) (MVK) [Danio rerio]
Length = 396
Score = 338 bits (868), Expect = 3e-91, Method: Composition-based stats.
Identities = 224/397 (56%), Positives = 294/397 (74%), Gaps = 4/397 (1%)
Query: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 60
M S L VSAPGKVILHGEH+VVHGKVALAVS+NLRT+LRLQ S+G+V ++LPNI
Sbjct: 1 MQSRELFVSAPGKVILHGEHSVVHGKVALAVSVNLRTYLRLQSTSSGQVCINLPNIDTFL 60
Query: 61 AWDVARLQSLD-TSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSI 119
+W++ LQ L S EQ D ++ ++KL+E G+ DD T +AVLAFLY+Y+++
Sbjct: 61 SWEITALQPLLAGSKAEQRDPKELDADLLKKLREFTGISDDSTDTRSMAVLAFLYMYITV 120
Query: 120 CRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTK 179
+ +L S+ + VWSELP GAGLGSSAAY+VCL+AALL+ I L RW+K
Sbjct: 121 FAE--SLASITVSVWSELPTGAGLGSSAAYNVCLSAALLSARGNISPLLMAQQESARWSK 178
Query: 180 EDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKV 239
+++ELIN+WAF GE++IHGNPSGVDNAV TWGG LRYH G I+ L P L+ILLTNTKV
Sbjct: 179 DEMELINRWAFMGEKIIHGNPSGVDNAVGTWGGFLRYHSGNITPLSWVPILRILLTNTKV 238
Query: 240 PRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGE-APAPEQYLVLEELI 298
PR+T+ LV+GV++++ KFP ++ P+L S+ A+S CE+ L EM E P+ E Y +LEELI
Sbjct: 239 PRSTKVLVSGVKDKINKFPSVMRPVLESVSAVSCTCEQTLTEMAEHGPSAEHYNILEELI 298
Query: 299 DMNQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQ 358
D+NQHHLN +GVGH+SLD LC+VT ++GLHSKLTGAGGGGCGITLL+P + +++T +
Sbjct: 299 DINQHHLNVMGVGHSSLDTLCRVTLSKGLHSKLTGAGGGGCGITLLRPETDTSVIQSTVE 358
Query: 359 ALTSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDG 395
L +CGFDC ETSIGAPGV HS+ ++ V + L+
Sbjct: 359 ELKACGFDCWETSIGAPGVQQHSSAAISPDVLKILNS 395
>ref|NP_001007350.1| hypothetical protein LOC492477 [Danio rerio]
gb|AAH85528.1| Zgc:103473 [Danio rerio]
gb|AAI64491.1| Zgc:103473 protein [synthetic construct]
Length = 396
Score = 338 bits (868), Expect = 4e-91, Method: Composition-based stats.
Identities = 224/397 (56%), Positives = 293/397 (73%), Gaps = 4/397 (1%)
Query: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 60
M S L VSAPGKVILHGEH+VVHGKVALAVS+NLRT+LRLQ S+G+V ++LPNI
Sbjct: 1 MQSRELFVSAPGKVILHGEHSVVHGKVALAVSVNLRTYLRLQSTSSGQVCINLPNIDTFL 60
Query: 61 AWDVARLQSLD-TSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSI 119
+W++ LQ L S EQ D ++ ++KL+E G+ DD T +AVLAFLY+YL++
Sbjct: 61 SWEITALQPLLAGSKAEQRDPKELDADLLKKLREFTGISDDSTDTRSMAVLAFLYMYLTV 120
Query: 120 CRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTK 179
+ +L S+ + VWSELP GAGLGSSAAY+VCL+AALL+ I L RW+K
Sbjct: 121 FAE--SLASITVSVWSELPTGAGLGSSAAYNVCLSAALLSARGNISPLLMAQQESARWSK 178
Query: 180 EDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKV 239
+++ELIN+WAF GE++IHGNPSGVDNAV TWGG LRYH G I+ L P L+ILLTNTKV
Sbjct: 179 DEMELINRWAFMGEKIIHGNPSGVDNAVGTWGGFLRYHSGNITPLSWVPILRILLTNTKV 238
Query: 240 PRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGE-APAPEQYLVLEELI 298
PR+T+ LV+GV++++ KFP ++ P+L S+ A+S CE+ L EM E P+ E Y +LEELI
Sbjct: 239 PRSTKVLVSGVKDKINKFPSVMRPVLESVSAVSCTCEQTLTEMAEHGPSAEHYNILEELI 298
Query: 299 DMNQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQ 358
D+NQHHLN +GVGH+SLD LC+VT ++GLHSKLTGAGGGGCGITLL+P + +++ +
Sbjct: 299 DINQHHLNVMGVGHSSLDTLCRVTLSKGLHSKLTGAGGGGCGITLLRPETDTSVIQSAVE 358
Query: 359 ALTSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDG 395
L +CGFDC ETSIGAPGV HS+ ++ V + L+
Sbjct: 359 ELKACGFDCWETSIGAPGVQQHSSAAISPDVLKILNS 395
>ref|XP_001382664.2| mevalonate kinase [Pichia stipitis CBS 6054]
gb|ABN64635.2| mevalonate kinase [Pichia stipitis CBS 6054]
Length = 432
Score = 335 bits (859), Expect = 4e-90, Method: Composition-based stats.
Identities = 140/405 (34%), Positives = 223/405 (55%), Gaps = 22/405 (5%)
Query: 2 LSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSN-GKVDLSLPNIGIKR 60
+S VSAPGKVI+ GEH+ V+GK A+A +L+LR +L + P + ++LS P+I +
Sbjct: 1 MSTPFFVSAPGKVIIFGEHSAVYGKPAIAAALSLRAYLLVTPSQDPDTINLSFPDINLTH 60
Query: 61 AWDVARLQSLDT----SFLEQGDVT--TPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLY 114
+W+ + + ++ T E V++L V L D + A L FLY
Sbjct: 61 SWNKNDIPWDSIVKHINLVDNLPQTSEELVPEIVDQLGSV--LADLNSSLHYTACLCFLY 118
Query: 115 LYLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDG-DC 173
LY +C + L + + S LP GAGLGSSA+ +VCLA+AL + + + D
Sbjct: 119 LYTHLC--NQELAGMSFCIRSTLPIGAGLGSSASTAVCLASALAILGNRVTSASFLQTDK 176
Query: 174 VNRWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGK-------ISSLKR 226
+ + DL+ I+ W+ GE+ HGNPSG+DNAV+T GGA+ + + +S++
Sbjct: 177 ILKKENNDLDFIDSWSLMGEKCFHGNPSGIDNAVATHGGAVMFQRMNNPAQPSVRTSMRN 236
Query: 227 SPALQILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAP 286
PA+++LLTNTKVPR+T LV GV +++P+ +L +++ +S +++ +
Sbjct: 237 FPAIKLLLTNTKVPRSTADLVGGVGKLNVEYPKTSNSILEAMEHLSNTAYQIM--VRPFF 294
Query: 287 APEQYLVLEELIDMNQHHLNALGVGHASLDQLCQVTRARGLHS-KLTGAGGGGCGITLLK 345
E+ L EL+++N L ALGV H SL+++ +T L S KLTGAGGGGC ITL+
Sbjct: 295 GAEERKKLRELVNINHGLLVALGVSHPSLEKVKIITDTSKLGSTKLTGAGGGGCAITLVD 354
Query: 346 PGLEQPEVEATKQALTSCGFDCLETSIGAPGVSIHSATSLDSRVQ 390
+ + ++ L G++C ETS+G GV S + ++
Sbjct: 355 EDVSEADIAQGIAELEKEGYECFETSLGGKGVGSLSFEDVPQELR 399
>ref|XP_918559.1| PREDICTED: similar to mevalonate kinase [Mus musculus]
Length = 382
Score = 332 bits (851), Expect = 4e-89, Method: Composition-based stats.
Identities = 285/366 (77%), Positives = 315/366 (86%)
Query: 28 ALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKRAWDVARLQSLDTSFLEQGDVTTPTSEQ 87
ALA +LNLRTFL L+P SNGKV ++LPNIGIK+ WDV LQ LDTSFLEQGDV+ PT EQ
Sbjct: 15 ALAAALNLRTFLLLRPQSNGKVSVNLPNIGIKQVWDVGMLQRLDTSFLEQGDVSVPTLEQ 74
Query: 88 VEKLKEVAGLPDDCAVTERLAVLAFLYLYLSICRKQRALPSLDIVVWSELPPGAGLGSSA 147
+EKLK++ LP D A E +A+LAFLYLYL+ICRKQR LPSLD+VVWSELPPGAGLGSSA
Sbjct: 75 LEKLKKMGDLPRDRAGNEGMALLAFLYLYLAICRKQRTLPSLDMVVWSELPPGAGLGSSA 134
Query: 148 AYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKEDLELINKWAFQGERMIHGNPSGVDNAV 207
AYSVCLAAALLT CEE+ NPLKDG V+RW +EDL+ INKWAF+GER+IHGNPSGVDNA+
Sbjct: 135 AYSVCLAAALLTACEEVSNPLKDGVSVSRWPEEDLKSINKWAFEGERVIHGNPSGVDNAI 194
Query: 208 STWGGALRYHQGKISSLKRSPALQILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTS 267
STWG ++ + S L R P+LQILLTNTKVPR+T+ALVA VR+RL KFPEIVAPLLTS
Sbjct: 195 STWGKSVCSLSSRESRLSRLPSLQILLTNTKVPRSTKALVAAVRSRLTKFPEIVAPLLTS 254
Query: 268 IDAISLECERVLGEMGEAPAPEQYLVLEELIDMNQHHLNALGVGHASLDQLCQVTRARGL 327
IDAISLECERVLGEM AP PEQYLVLEELIDMNQHHLNALGVGH SLDQLCQVT A GL
Sbjct: 255 IDAISLECERVLGEMVAAPVPEQYLVLEELIDMNQHHLNALGVGHNSLDQLCQVTAAHGL 314
Query: 328 HSKLTGAGGGGCGITLLKPGLEQPEVEATKQALTSCGFDCLETSIGAPGVSIHSATSLDS 387
HSKLTGAGGGGCGITLLKPGLEQ VEA KQALTSCGFDC ETSIGAPGVS HSA ++
Sbjct: 315 HSKLTGAGGGGCGITLLKPGLEQATVEAAKQALTSCGFDCWETSIGAPGVSTHSAAAVGD 374
Query: 388 RVQQAL 393
V+QAL
Sbjct: 375 PVRQAL 380
>ref|XP_370449.1| hypothetical protein MGG_06946 [Magnaporthe grisea 70-15]
gb|EDJ98120.1| hypothetical protein MGG_06946 [Magnaporthe grisea 70-15]
Length = 494
Score = 331 bits (848), Expect = 7e-89, Method: Composition-based stats.
Identities = 135/407 (33%), Positives = 206/407 (50%), Gaps = 28/407 (6%)
Query: 2 LSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGK--VDLSLPNIGIK 59
+ +VSAPGKVI+ GEH+VV+GK A+A ++NLR++L + S K + L P+I +
Sbjct: 43 MMPAFMVSAPGKVIVFGEHSVVYGKKAVAAAINLRSYLLVTALSKSKRTITLRFPDIDLI 102
Query: 60 RAWDVARLQS-----LDTSFLEQGDVTTPTSEQVEKLKEVA-----GLPDDCAVTERLAV 109
W++ L VT+ + ++ ++ PD A
Sbjct: 103 HTWNIDDLPWSTFSQPSKKKYYYDLVTSLDPDLMDAIQPHLEPVSSDAPDAQRKVHMSAA 162
Query: 110 LAFLYLYLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLK 169
AFLYL++S+ A P + S +P GAGLGSSA+ S CL+AALL + P
Sbjct: 163 AAFLYLFMSLGS--HAFPGGIYTLRSTIPIGAGLGSSASISACLSAALLLQIRTLSGPHP 220
Query: 170 DGDCVNRWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGK------ISS 223
D + +E IN+WAF E IHGNPSGVDN VST G A+ + + ++
Sbjct: 221 DQPPDE--ARVQVERINRWAFVAEMCIHGNPSGVDNTVSTQGKAVVFQRLDYARPPVVTP 278
Query: 224 LKRSPALQILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMG 283
+ P L +L+ +TK ++T+ V V P+IV +L S+D ++ VL +
Sbjct: 279 MWDFPELPLLVVDTKQAKSTKYEVEKVAKLRETHPKIVNSILDSMDKLTQAATDVLTD-- 336
Query: 284 EAPAPEQYLVL---EELIDMNQHHLNALGVGHASLDQLCQVTRARGLH-SKLTGAGGGGC 339
E E L EL+ MN L +LGV H L+++ ++ G+ +KLTGAGGGGC
Sbjct: 337 EDFDNEDVESLQKVGELMGMNHGLLVSLGVSHPRLERVRELVDHEGIGWTKLTGAGGGGC 396
Query: 340 GITLLKPGLEQPEVEATKQALTSCGFDCLETSIGAPGVSIHSATSLD 386
ITL++P + + ++E K+ L G+ T++G GV + L
Sbjct: 397 SITLMRPDVPREKLERLKERLDHEGYLKFRTTLGGGGVGVLWPAVLR 443
>gb|EEH37797.1| mevalonate kinase [Paracoccidioides brasiliensis Pb01]
Length = 545
Score = 327 bits (839), Expect = 9e-88, Method: Composition-based stats.
Identities = 128/405 (31%), Positives = 194/405 (47%), Gaps = 40/405 (9%)
Query: 2 LSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNG--KVDLSLPNIGIK 59
++ +VSAPGKVI+ GEHAVVHGK A+A +++LR++L + S + L+ +I +
Sbjct: 109 MAPAFMVSAPGKVIVFGEHAVVHGKRAMAAAISLRSYLLVTTLSKSQRTITLNFRDIELD 168
Query: 60 RAWDVARLQSL-----DTSFLEQGDVTTPTSEQVEKLKE-----VAGLPDDCAVTERLAV 109
WD+ L VT+ E +E ++ G PD+ R +
Sbjct: 169 HTWDIDSLPWALFCQPSKKKFYYDSVTSLDPELLEAIQPHIADISIGKPDEVQKIHRSSA 228
Query: 110 LAFLYLYLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLK 169
AFLYL+LS+ + + S +P GAGLGSSA+ +VCL+AALL + P
Sbjct: 229 TAFLYLFLSLSSPGS--HAAIYTLRSTIPIGAGLGSSASIAVCLSAALLLQIRILAGPHH 286
Query: 170 DGDCVNRWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGK------ISS 223
D + +E IN+WAF GE IHGNPSGVDN VS G A+ + +G ++
Sbjct: 287 DQPP--EEAEVQIERINRWAFVGEMCIHGNPSGVDNTVSAGGKAVIFRRGDYSKPPSVTP 344
Query: 224 LKRSPALQILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMG 283
+ P L +LL + P P + L +ID ++ +
Sbjct: 345 ILDFPELPLLLAGSAKP----------------TPAVAESTLAAIDQVTESANNFIQSGR 388
Query: 284 -EAPAPEQYLVLEELIDMNQHHLNALGVGHASLDQLCQVTRARGLH-SKLTGAGGGGCGI 341
+ + E EL +N L +LGV H L+++ ++ G+ +KLTGAGGGGC I
Sbjct: 389 FDKDSNEDIDHFGELFRINHGLLVSLGVSHPRLERIRELVDHAGIGWTKLTGAGGGGCAI 448
Query: 342 TLLKPGLEQPEVEATKQALTSCGFDCLETSIGAPGVSIHSATSLD 386
LL+ Q + +Q L GF+ ET++G G+ + L
Sbjct: 449 VLLRANTNQAVLHHLEQNLDDEGFERYETTLGGDGIGVLWPAVLK 493
>emb|CAG08527.1| unnamed protein product [Tetraodon nigroviridis]
Length = 394
Score = 326 bits (835), Expect = 3e-87, Method: Composition-based stats.
Identities = 224/395 (56%), Positives = 276/395 (69%), Gaps = 3/395 (0%)
Query: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 60
M + VSAPGK ILHGEHAVVHGKVALAVSLNLR++LRL+ S G V ++LPNI
Sbjct: 1 MQVGDIYVSAPGKAILHGEHAVVHGKVALAVSLNLRSYLRLEATSTGTVGVNLPNIDTFL 60
Query: 61 AWDVARLQSLDTSFLEQ-GDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSI 119
W+++ L+ S G V + + +L+E G+ + T ++A L FLYLYLS
Sbjct: 61 HWNLSELKQFAPSVTGGTGQVKLLDPDLLRRLREYVGVANGNLNTSQMATLTFLYLYLS- 119
Query: 120 CRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTK 179
LPSL + VWSELP GAGLGSSAAY+VCLAAALL I +PLK+ + RW +
Sbjct: 120 AFGSGELPSLTVSVWSELPTGAGLGSSAAYTVCLAAALLCASGAISSPLKEWEHTARWCQ 179
Query: 180 EDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKV 239
E+LELIN WAFQGE +IHGNPSGVDNAV TWGG LR+ GKI L R P L+ILLTNTKV
Sbjct: 180 EELELINSWAFQGEMIIHGNPSGVDNAVGTWGGMLRFLAGKIIPLSRVPLLRILLTNTKV 239
Query: 240 PRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEM-GEAPAPEQYLVLEELI 298
PR+T+ LV+ V++++ KFP ++AP+L S+DAIS CE+VL EM E E Y LEELI
Sbjct: 240 PRSTKVLVSRVKDKINKFPSVMAPVLDSVDAISCTCEKVLSEMTSEPITGEHYNALEELI 299
Query: 299 DMNQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQ 358
D+NQHHLN +GVGH +LD LC++T +GLHSKLTGAGGGGCGITLL+P V+AT Q
Sbjct: 300 DINQHHLNVMGVGHPALDTLCRITLTKGLHSKLTGAGGGGCGITLLRPETGSAVVQATVQ 359
Query: 359 ALTSCGFDCLETSIGAPGVSIHSATSLDSRVQQAL 393
L CGFDC ETSIG PGV H+ S+ + + L
Sbjct: 360 DLKDCGFDCWETSIGGPGVQQHAPVSVKEEILEVL 394
>gb|AAD45421.1|L77688_1 mevalonate kinase [Arabidopsis thaliana]
Length = 376
Score = 317 bits (812), Expect = 1e-84, Method: Composition-based stats.
Identities = 140/379 (36%), Positives = 223/379 (58%), Gaps = 10/379 (2%)
Query: 5 VLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQ---PHSNGKVDLSLPNIGIKRA 61
+ APGK+IL GEHAVVHG A+A +++L T++ L+ P +N ++ L L +I ++ +
Sbjct: 2 EVKARAPGKIILAGEHAVVHGSTAVAAAIDLYTYVTLRFPLPSNNDRLTLQLKDISLEFS 61
Query: 62 WDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVT-ERLAVLAFLYLYLSIC 120
W +AR++ +TP S E LK +A L ++ + E++ + + + +L +
Sbjct: 62 WSLARIKEAIPYDSSTLCRSTPASCSEETLKSIAVLVEEQNLPKEKMWLSSGISTFLWLY 121
Query: 121 RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE 180
+ +V+ SELP G+GLGSSAA V L AALL + G+ + +
Sbjct: 122 TRIIGFNPATVVINSELPYGSGLGSSAALCVALTAALLASS---ISEKTRGNGWSSLDET 178
Query: 181 DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP 240
+LEL+NKWAF+GE++IHG PSG+DN VS +G +++ G+I+ L+ + L++L+TNT+V
Sbjct: 179 NLELLNKWAFEGEKIIHGKPSGIDNTVSAYGNMIKFCSGEITRLQSNMPLRMLITNTRVG 238
Query: 241 RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM 300
RNT+ALV+GV R ++ P+ + + ++D+IS E ++ E E+ ++EL++M
Sbjct: 239 RNTKALVSGVSQRAVRHPDAMKSVFNAVDSISKELAAIIQSKDETSVTEKEERIKELMEM 298
Query: 301 NQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL 360
NQ L ++GV H+S++ + T L SKLTGAGGGGC +TLL G V+ + L
Sbjct: 299 NQGLLLSMGVSHSSIEAVILTTVKHKLVSKLTGAGGGGCVLTLLPTG---TVVDKVVEEL 355
Query: 361 TSCGFDCLETSIGAPGVSI 379
S GF C IG G I
Sbjct: 356 ESSGFQCFTALIGGNGAQI 374
>ref|NP_198097.1| MK/MVK; mevalonate kinase [Arabidopsis thaliana]
ref|NP_851084.1| MK/MVK; mevalonate kinase [Arabidopsis thaliana]
sp|P46086|KIME_ARATH Mevalonate kinase (MK)
gb|AAD31719.1|AF141853_1 mevalonate kinase [Arabidopsis thaliana]
emb|CAA54820.1| mevalonate kinase [Arabidopsis thaliana]
gb|AAM13164.1| mevalonate kinase [Arabidopsis thaliana]
gb|AAM60916.1| mevalonate kinase [Arabidopsis thaliana]
gb|AAN72115.1| mevalonate kinase [Arabidopsis thaliana]
Length = 378
Score = 312 bits (800), Expect = 3e-83, Method: Composition-based stats.
Identities = 139/381 (36%), Positives = 222/381 (58%), Gaps = 12/381 (3%)
Query: 5 VLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQP-----HSNGKVDLSLPNIGIK 59
+ APGK+IL GEHAVVHG A+A +++L T++ L+ +N ++ L L +I ++
Sbjct: 2 EVKARAPGKIILAGEHAVVHGSTAVAAAIDLYTYVTLRFPLPSAENNDRLTLQLKDISLE 61
Query: 60 RAWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVT-ERLAVLAFLYLYLS 118
+W +AR++ +TP S E LK +A L ++ + E++ + + + +L
Sbjct: 62 FSWSLARIKEAIPYDSSTLCRSTPASCSEETLKSIAVLVEEQNLPKEKMWLSSGISTFLW 121
Query: 119 ICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWT 178
+ + +V+ SELP G+GLGSSAA V L AALL + G+ +
Sbjct: 122 LYTRIIGFNPATVVINSELPYGSGLGSSAALCVALTAALLASS---ISEKTRGNGWSSLD 178
Query: 179 KEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTK 238
+ +LEL+NKWAF+GE++IHG PSG+DN VS +G +++ G+I+ L+ + L++L+TNT+
Sbjct: 179 ETNLELLNKWAFEGEKIIHGKPSGIDNTVSAYGNMIKFCSGEITRLQSNMPLRMLITNTR 238
Query: 239 VPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELI 298
V RNT+ALV+GV R ++ P+ + + ++D+IS E ++ E E+ ++EL+
Sbjct: 239 VGRNTKALVSGVSQRAVRHPDAMKSVFNAVDSISKELAAIIQSKDETSVTEKEERIKELM 298
Query: 299 DMNQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQ 358
+MNQ L ++GV H+S++ + T L SKLTGAGGGGC +TLL G V+ +
Sbjct: 299 EMNQGLLLSMGVSHSSIEAVILTTVKHKLVSKLTGAGGGGCVLTLLPTG---TVVDKVVE 355
Query: 359 ALTSCGFDCLETSIGAPGVSI 379
L S GF C IG G I
Sbjct: 356 ELESSGFQCFTALIGGNGAQI 376
>ref|XP_001483309.1| hypothetical protein PGUG_04038 [Pichia guilliermondii ATCC 6260]
gb|EDK39940.1| hypothetical protein PGUG_04038 [Pichia guilliermondii ATCC 6260]
Length = 423
Score = 312 bits (799), Expect = 4e-83, Method: Composition-based stats.
Identities = 130/393 (33%), Positives = 201/393 (51%), Gaps = 21/393 (5%)
Query: 2 LSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKRA 61
++ +SAPGKVIL GEHA V+GK ALA +L+LR +L ++ + L P+I + +
Sbjct: 1 MAP-FYISAPGKVILFGEHAAVYGKPALAAALSLRAYLLATETNDDSLRLEFPDIQLSHS 59
Query: 62 WDVARLQS------LDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYL 115
W ++ L ++ + E + + E G + + L FLYL
Sbjct: 60 WKLSELPWENAQAHIERKNGKPVPTDELNPEVINLIGEFLGDIE--STAHYTTCLCFLYL 117
Query: 116 YLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVN 175
YL +C A S + S LP GAGLGSSA+ +VCL + L + I +P
Sbjct: 118 YLHLCDPLVASRSF--CIRSTLPIGAGLGSSASAAVCLTSTLALLGGHIRSPQYSEKQRV 175
Query: 176 RWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQ-------GKISSLKRSP 228
D E I+ W+ GE+ HGNPSG+DNAV+T GGA+ Y + ++++ P
Sbjct: 176 SSENPDAEFIDSWSLMGEKCFHGNPSGIDNAVATHGGAVMYQRMLAPDMPSVRTAMRNFP 235
Query: 229 ALQILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAP 288
L++LLTNTKVPR+T LV GV + P+ +L ++ ++ + ++ + A
Sbjct: 236 PLKLLLTNTKVPRSTAELVGGVAKVNTRHPKTAGSILDAVSHLATDAYHIMS--HPSFAA 293
Query: 289 EQYLVLEELIDMNQHHLNALGVGHASLDQLCQVTRARGLHS-KLTGAGGGGCGITLLKPG 347
E L +L+++N L ALGV H +L+++ + + + KLTGAGGGGC ITLL
Sbjct: 294 EDRESLRQLVNINHGLLVALGVSHPALEKIKMIGDTNRIGATKLTGAGGGGCAITLLNDE 353
Query: 348 LEQPEVEATKQALTSCGFDCLETSIGAPGVSIH 380
+ +E + T GF+ E ++G GV
Sbjct: 354 VSHEVLEKVENEFTQEGFETFEATLGGKGVGAL 386
>ref|XP_001628178.1| predicted protein [Nematostella vectensis]
gb|EDO36115.1| predicted protein [Nematostella vectensis]
Length = 415
Score = 308 bits (788), Expect = 7e-82, Method: Composition-based stats.
Identities = 163/415 (39%), Positives = 235/415 (56%), Gaps = 31/415 (7%)
Query: 1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPH-SNGKVDLSLPNIGIK 59
M ++VSAPGK+ILHGEHAVV+GK A+AVS+ LRT + LQ H + KV L L ++
Sbjct: 1 MKLSRVVVSAPGKIILHGEHAVVYGKAAIAVSIGLRTTVVLQRHKNESKVSLLLKDLDYI 60
Query: 60 RAWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTE----RLAVLAFLYL 115
WD+ +Q + + Q T E L + L D E + A FL+L
Sbjct: 61 LTWDLTDIQKILVAVP-QVSRTDTVLPSDEMLSLIDKLIDSSKFVEVEGVKDAARVFLFL 119
Query: 116 YLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPL------- 168
S R + LP++++ V + LP GAGLGSSAAYS+ LAAA+L + IP P
Sbjct: 120 MTSTLRDRDRLPAIEVEVKTALPLGAGLGSSAAYSISLAAAMLLSMQTIPLPKYVKKTPE 179
Query: 169 -------KDGDCVNRWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKI 221
D + E L L+ +WAF+ E+++HG PSG+DN+++T+GGAL + G+I
Sbjct: 180 SETTAKDTDSYQYDDIETESLRLVCQWAFEAEKIMHGQPSGIDNSIATYGGALLFQNGEI 239
Query: 222 SSLKRSPALQILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGE 281
+ L+ P L ILL +T++PR+TR +VAGVR+R ++FP + L ++D I EC ++ +
Sbjct: 240 THLESMPLLSILLIDTQIPRSTRVMVAGVRDRYIEFPTVYMSLFEAVDGICHECIKIFSK 299
Query: 282 MGEAPAPEQ---------YLVLEELIDMNQHHLNALGVGHASLDQLCQVTRARGLHSKLT 332
+ E Y LE L+D+NQ L+ GV H SLD LC +T GLH+KLT
Sbjct: 300 IHN-LKNEDVPKSEFVRYYQRLESLVDVNQQLLSLFGVSHPSLDSLCHMTSKYGLHTKLT 358
Query: 333 GAGGGGCGITLLKPGLEQPEVEATKQALTSC-GFDCLETSIGAPGVSIHSATSLD 386
GAGGGGC ITL+ PG ++ +V L + +T +G+ GV +H A +D
Sbjct: 359 GAGGGGCAITLIPPGTDKDKVAELMNKLQKEFKYKVWQTPLGSRGVIVHEAIPVD 413
>gb|ABK95983.1| unknown [Populus trichocarpa]
Length = 387
Score = 305 bits (782), Expect = 4e-81, Method: Composition-based stats.
Identities = 152/391 (38%), Positives = 225/391 (57%), Gaps = 17/391 (4%)
Query: 5 VLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQP----HSNGKVDLSLPNIGIKR 60
+ APGK+IL GEHAVVHG A+A S+ L T++ LQ ++ ++ L L ++ ++
Sbjct: 2 EVKARAPGKIILSGEHAVVHGSTAVAASIGLCTYVSLQVPPSNENDDRLTLQLKDMALEF 61
Query: 61 AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTE-----RLAVLAFLYL 115
+W + R++ +S T PTS E K + L ++ + E V AFL+L
Sbjct: 62 SWPIGRIKEALSSLGGPFPST-PTSCSAESFKLILALIEEQNILEEKISLASGVSAFLWL 120
Query: 116 YLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVN 175
Y SI + +VV S+LP G+GLGSSAA V +AALL + + +K +
Sbjct: 121 YTSIL----GIKPATVVVTSDLPLGSGLGSSAALCVAFSAALLACSDTVNIDMK-QEGWL 175
Query: 176 RWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLT 235
+ + +LEL+NKWAF+GE++IHG PSG+DN VST+G +++ G ++ +K S L++L+T
Sbjct: 176 VFGESELELLNKWAFEGEKIIHGKPSGIDNTVSTYGNMIKFRSGNLTRIKSSMPLKMLIT 235
Query: 236 NTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMG--EAPAPEQYLV 293
NTKV RNT+ALVAGV R L+ P+ ++ + ++D+IS E V+ + +
Sbjct: 236 NTKVGRNTKALVAGVSERTLRNPDAMSSVFNAVDSISKELANVIQTPASDDLSITAKEEK 295
Query: 294 LEELIDMNQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEV 353
LEEL++MN L +GV HAS++ + + T L SKLTGAGGGGC +TLL L V
Sbjct: 296 LEELMEMNHGLLQCMGVSHASIETVLRTTLKYKLASKLTGAGGGGCVLTLLPTLLSGTIV 355
Query: 354 EATKQALTSCGFDCLETSIGAPGVSIHSATS 384
+ L SCGF CL IG G I + S
Sbjct: 356 DKVIAELESCGFQCLIAGIGGNGAEICFSAS 386
>emb|CAO17636.1| unnamed protein product [Vitis vinifera]
Length = 388
Score = 302 bits (774), Expect = 3e-80, Method: Composition-based stats.
Identities = 150/386 (38%), Positives = 219/386 (56%), Gaps = 17/386 (4%)
Query: 5 VLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPH----SNGKVDLSLPNIGIKR 60
+ APGK+IL GEHAVVHG A+A S+NL T + L+ H + + L L ++ ++
Sbjct: 2 EVRARAPGKIILAGEHAVVHGSAAVAASINLYTHVSLRFHSISDDDHTLKLHLKDMALEF 61
Query: 61 AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERL-----AVLAFLYL 115
+W + R++ + T PT+ E +K +A L + + E V AFL+L
Sbjct: 62 SWSIERIKEVLQEVGCPFSST-PTTCTPEFIKLIAALLIEQNIPEAKLGLASGVSAFLWL 120
Query: 116 YLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVN 175
Y I + +V+ SELP G+GLGSSA++ V L+AALL + + +
Sbjct: 121 YTCI----QGFKPATVVITSELPLGSGLGSSASFCVSLSAALLALSDSASLDFS-HPGWS 175
Query: 176 RWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLT 235
+ + +LEL+NKWAF+GE++IHG PSG+DN+VST+G +++ G ++ L + L++L+T
Sbjct: 176 VFGENELELVNKWAFEGEKIIHGKPSGIDNSVSTFGNMIKFKSGSLTRLSSNMPLKMLVT 235
Query: 236 NTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMG--EAPAPEQYLV 293
NTKV RNT+ALVAGV R L+ P + + ++D IS E ++ E E+
Sbjct: 236 NTKVGRNTKALVAGVSERTLRHPNAMKAVFNAVDFISEELSTIIQSPAPDELSITEKEEK 295
Query: 294 LEELIDMNQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEV 353
L EL++MNQ L +GV HAS++ + + T L SKLTGAGGGGC +TLL L V
Sbjct: 296 LGELMEMNQGLLQCMGVSHASIETVLRTTLKYKLASKLTGAGGGGCVLTLLPTLLSGTVV 355
Query: 354 EATKQALTSCGFDCLETSIGAPGVSI 379
AL SC F CL IG GV I
Sbjct: 356 NKVIAALESCEFQCLIAGIGGNGVEI 381
>ref|XP_567851.1| cystathionine beta-lyase [Cryptococcus neoformans var. neoformans
JEC21]
ref|XP_772806.1| hypothetical protein CNBK1800 [Cryptococcus neoformans var.
neoformans B-3501A]
gb|EAL18159.1| hypothetical protein CNBK1800 [Cryptococcus neoformans var.
neoformans B-3501A]
gb|AAW46334.1| cystathionine beta-lyase, putative [Cryptococcus neoformans var.
neoformans JEC21]
Length = 900
Score = 300 bits (768), Expect = 1e-79, Method: Composition-based stats.
Identities = 152/408 (37%), Positives = 218/408 (53%), Gaps = 21/408 (5%)
Query: 2 LSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKRA 61
+ E + VSAPGKVIL GEHAVVHG A+A S++LR F L P +GKV L +PNIG++
Sbjct: 478 IEEDIAVSAPGKVILFGEHAVVHGVTAIASSVDLRCFSVLSPRRDGKVGLEVPNIGVELE 537
Query: 62 WDVARLQSLDTSFLEQGDVTTPTSEQ----VEKLKEVAGLPDDCAVTERLAVLAFLYLYL 117
W++++L G E ++ ++ + T A +AFLYLY+
Sbjct: 538 WEISKLPWNLLPVHANGGRHVADKELDTALLQAVEGAVNTHVEVGKTGIGACVAFLYLYM 597
Query: 118 SICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRW 177
I ++ S+ S LP AGLGSSAAYS C+AA+ L + + P D R
Sbjct: 598 MISGEETNALSVTFTASSNLPISAGLGSSAAYSTCVAASFLLARQHLTIPSAD-----RL 652
Query: 178 TKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQ------GKISSLKRSPALQ 231
KED +L++ WAF E+++HGNPSG+DNAV+ GGA+ + + G + L +++
Sbjct: 653 PKEDTDLVDGWAFLAEKVLHGNPSGIDNAVAVRGGAVAFTRSVGGKQGGMDGLFEFSSVR 712
Query: 232 ILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQY 291
+LLTNT VPR+T+ LVAGV + L P+ V +L SI IS E +LG
Sbjct: 713 LLLTNTLVPRDTKTLVAGVSAKRLAEPQAVNSILDSIQTISDEARSLLGGGKPVERSILV 772
Query: 292 LVLEELIDMNQHHLNALGVGHASLDQLCQVTRARG--LHSKLTGAGGGGCGITLLKPGLE 349
LE LI N HL LGV H SL+ + T L +KLTGAGGGGC +TL+
Sbjct: 773 KRLEALIKENHEHLVELGVSHPSLEMIVAATAQAPFELATKLTGAGGGGCALTLIPDDFP 832
Query: 350 QPEVEATKQALTSCGFDCLETSIGAPGVSIHS----ATSLDSRVQQAL 393
+ + Q L GF T++G PG + + ++ +++ A+
Sbjct: 833 ESSLNELIQTLEGHGFQAHLTTLGGPGFGVLTTPFKPGNVSEQLRDAV 880
>gb|AAL18925.1|AF429384_1 mevalonate kinase [Hevea brasiliensis]
dbj|BAF98283.1| mevalonate kinase [Hevea brasiliensis]
Length = 386
Score = 300 bits (768), Expect = 1e-79, Method: Composition-based stats.
Identities = 147/383 (38%), Positives = 223/383 (58%), Gaps = 16/383 (4%)
Query: 5 VLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPH---SNGKVDLSLPNIGIKRA 61
+ APGK+IL GEHAVVHG A+A S+NL T++ L ++ + L L ++ ++ +
Sbjct: 2 EVKARAPGKIILSGEHAVVHGSTAVAASINLYTYVTLSFATAENDDSLKLQLKDLALEFS 61
Query: 62 WDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVL-----AFLYLY 116
W + R++ ++ T TS +E +K ++ L ++ + E L AFL+LY
Sbjct: 62 WPIGRIREALSNLGAPSSST-RTSCSMESIKTISALVEEENIPEAKIALTSGVSAFLWLY 120
Query: 117 LSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNR 176
SI + +VV S+LP G+GLGSSAA+ V L+AALL + + +
Sbjct: 121 TSI----QGFKPATVVVTSDLPLGSGLGSSAAFCVALSAALLAFSDSVNVD-TKHLGWSI 175
Query: 177 WTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTN 236
+ + DLEL+NKWA +GE++IHG PSG+DN VS +G +++ G ++ +K + L++L+TN
Sbjct: 176 FGESDLELLNKWALEGEKIIHGKPSGIDNTVSAYGNMIKFKSGNLTRIKSNMPLKMLVTN 235
Query: 237 TKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMG--EAPAPEQYLVL 294
T+V RNT+ALVAGV R L+ P ++ + ++D+IS E ++ + E+ L
Sbjct: 236 TRVGRNTKALVAGVSERTLRHPNAMSFVFNAVDSISNELANIIQSPAPDDVSITEKEEKL 295
Query: 295 EELIDMNQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVE 354
EEL++MNQ L +GV HAS++ + + T L SKLTGAGGGGC +TLL L V+
Sbjct: 296 EELMEMNQGLLQCMGVSHASIETVLRTTLKYKLASKLTGAGGGGCVLTLLPTLLSGTVVD 355
Query: 355 ATKQALTSCGFDCLETSIGAPGV 377
L SCGF CL IG GV
Sbjct: 356 KAIAELESCGFQCLIAGIGGNGV 378
Database: All non-redundant GenBank CDS
translations+PDB+SwissProt+PIR+PRF excluding environmental samples
from WGS projects
Posted date: May 23, 2008 5:56 PM
Number of letters in database: 883,778,997
Number of sequences in database: 2,617,685
Database: /host/Blast/data/nr_perl/nr.01
Posted date: May 23, 2008 5:54 PM
Number of letters in database: 976,759,346
Number of sequences in database: 2,761,413
Database: /host/Blast/data/nr_perl/nr.02
Posted date: May 23, 2008 5:48 PM
Number of letters in database: 374,670,760
Number of sequences in database: 1,165,270
Database: /host/Blast/data/nr_perl/nr.03
Posted date: Apr 28, 2009 5:40 PM
Number of letters in database: 114,943,120
Number of sequences in database: 354,819
Lambda K H
0.313 0.143 0.355
Lambda K H
0.267 0.0436 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 4,967,089,701
Number of Sequences: 6899187
Number of extensions: 203875641
Number of successful extensions: 779724
Number of sequences better than 10.0: 300
Number of HSP's better than 10.0 without gapping: 3892
Number of HSP's successfully gapped in prelim test: 2501
Number of HSP's that attempted gapping in prelim test: 762745
Number of HSP's gapped (non-prelim): 9177
length of query: 396
length of database: 2,350,152,223
effective HSP length: 136
effective length of query: 260
effective length of database: 1,411,862,791
effective search space: 367084325660
effective search space used: 367084325660
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.3 bits)
S2: 80 (35.3 bits)