BLASTP 2.2.17 [Aug-26-2007]
Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Reference for composition-based statistics:
Schäffer, Alejandro A., L. Aravind, Thomas L. Madden,
Schaffer, Alejandro A., L. Aravind, Thomas L. Madden,
Sergei Shavirin, John L. Spouge, Yuri I. Wolf,
Eugene V. Koonin, and Stephen F. Altschul (2001),
"Improving the accuracy of PSI-BLAST protein database searches with
composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005.
Query= ENSG00000117305__[Homo_sapiens]
(325 letters)
Database: All non-redundant GenBank CDS
translations+PDB+SwissProt+PIR+PRF excluding environmental samples
from WGS projects
6,899,187 sequences; 2,350,152,223 total letters
Searching..................................................done
Results from round 1
Score E
Sequences producing significant alignments: (bits) Value
ref|NP_000182.2| 3-hydroxymethyl-3-methylglutaryl-Coenzyme ... 624 e-177
ref|XP_001166273.1| PREDICTED: 3-hydroxymethyl-3-methylglut... 624 e-177
gb|AAA92733.1| hydroxymethylglutaryl-CoA lyase [Homo sapiens] 623 e-177
sp|Q5R9E1|HMGCL_PONPY Hydroxymethylglutaryl-CoA lyase, mito... 613 e-174
sp|Q8HXZ6|HMGCL_MACFA Hydroxymethylglutaryl-CoA lyase, mito... 598 e-169
dbj|BAE88248.1| unnamed protein product [Macaca fascicularis] 595 e-168
ref|XP_513200.2| PREDICTED: similar to 3-hydroxymethyl-3-me... 590 e-167
gb|AAB19099.1| hydroxymethylglutaryl-CoA lyase 587 e-166
emb|CAI23161.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A... 583 e-165
ref|XP_001166216.1| PREDICTED: similar to 3-hydroxymethyl-3... 582 e-164
pdb|2CW6|A Chain A, Crystal Structure Of Human Hmg-Coa Lyas... 580 e-164
ref|NP_077362.1| 3-hydroxy-3-methylglutaryl-Coenzyme A lyas... 571 e-161
ref|XP_001504254.1| PREDICTED: similar to interleukin 13 re... 569 e-160
ref|NP_001068600.1| 3-hydroxymethyl-3-methylglutaryl-Coenzy... 565 e-159
ref|NP_032280.2| 3-hydroxy-3-methylglutaryl-Coenzyme A lyas... 565 e-159
gb|AAB03107.1| 3-hydroxy-3-methylglutaryl-CoA lyase 562 e-158
dbj|BAE26056.1| unnamed protein product [Mus musculus] 560 e-158
sp|P38060|HMGCL_MOUSE Hydroxymethylglutaryl-CoA lyase, mito... 558 e-157
ref|XP_001104722.1| PREDICTED: 3-hydroxymethyl-3-methylglut... 557 e-157
ref|XP_535360.2| PREDICTED: similar to Hydroxymethylglutary... 546 e-154
ref|XP_001166145.1| PREDICTED: similar to 3-hydroxymethyl-3... 539 e-151
ref|XP_417834.1| PREDICTED: similar to Hydroxymethylglutary... 498 e-139
ref|XP_001363832.1| PREDICTED: similar to alpha-2-macroglob... 484 e-135
sp|P35915|HMGCL_CHICK Hydroxymethylglutaryl-CoA lyase (HMG-... 482 e-134
gb|AAA92728.1| hydroxymethylglutaryl-CoA lyase 471 e-131
ref|NP_957509.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme ... 471 e-131
ref|NP_001085152.1| hypothetical protein LOC432233 [Xenopus... 464 e-129
emb|CAG09900.1| unnamed protein product [Tetraodon nigrovir... 462 e-128
gb|AAL89669.1|AF411956_10 hydroxymethylglutaryl-CoA lyase [... 453 e-126
ref|XP_538973.2| PREDICTED: similar to 3-hydroxymethyl-3-me... 449 e-124
ref|XP_001499476.1| PREDICTED: similar to 3-hydroxymethyl-3... 449 e-124
ref|NP_061909.2| 3-hydroxymethyl-3-methylglutaryl-Coenzyme ... 449 e-124
ref|XP_001105003.1| PREDICTED: similar to 3-hydroxymethyl-3... 448 e-124
ref|XP_419903.1| PREDICTED: similar to 3-hydroxymethyl-3-me... 447 e-124
ref|NP_001035865.1| 3-hydroxymethyl-3-methylglutaryl-Coenzy... 447 e-124
ref|XP_001371535.1| PREDICTED: similar to 3-hydroxymethyl-3... 440 e-122
ref|NP_776092.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme ... 439 e-121
ref|XP_615612.3| PREDICTED: similar to 3-hydroxymethyl-3-me... 437 e-121
gb|EDL77774.1| similar to 3-hydroxymethyl-3-methylglutaryl-... 437 e-121
ref|NP_001103870.1| hypothetical protein LOC571388 [Danio r... 436 e-120
ref|XP_001252308.1| PREDICTED: similar to 3-hydroxymethyl-3... 435 e-120
ref|XP_345954.2| PREDICTED: similar to 3-hydroxymethyl-3-me... 432 e-119
ref|XP_001196745.1| PREDICTED: similar to MGC82338 protein ... 412 e-113
ref|XP_001638492.1| predicted protein [Nematostella vectens... 398 e-109
dbj|BAE71196.1| putative hydroxymethylglutaryl-CoA lyase [T... 393 e-107
gb|EAZ11369.1| hypothetical protein OsJ_001194 [Oryza sativ... 393 e-107
gb|EAY73450.1| hypothetical protein OsI_001297 [Oryza sativ... 392 e-107
ref|XP_314824.4| AGAP008717-PA [Anopheles gambiae str. PEST... 392 e-107
ref|XP_001355781.1| GA10298-PA [Drosophila pseudoobscura] >... 392 e-107
gb|ABA95738.2| Hydroxymethylglutaryl-CoA lyase, mitochondri... 391 e-107
emb|CAO67270.1| unnamed protein product [Vitis vinifera] 388 e-106
ref|NP_565629.1| hydroxymethylglutaryl-CoA lyase, putative ... 387 e-106
ref|NP_001065695.1| Os11g0137200 [Oryza sativa (japonica cu... 387 e-106
ref|NP_001066093.1| Os12g0134000 [Oryza sativa (japonica cu... 386 e-105
ref|NP_850087.1| hydroxymethylglutaryl-CoA lyase, putative ... 383 e-104
dbj|BAD81168.1| putative hydroxymethylglutaryl-CoA lyase [O... 382 e-104
ref|NP_001042696.1| Os01g0269000 [Oryza sativa (japonica cu... 382 e-104
gb|AAY55779.1| IP10508p [Drosophila melanogaster] 381 e-104
ref|NP_609089.1| CG10399 CG10399-PA [Drosophila melanogaste... 381 e-104
ref|XP_001767580.1| predicted protein [Physcomitrella paten... 380 e-104
ref|XP_001748375.1| predicted protein [Monosiga brevicollis... 379 e-103
emb|CAO18214.1| unnamed protein product [Vitis vinifera] 378 e-103
ref|XP_001654565.1| hydroxymethylglutaryl-coa lyase [Aedes ... 377 e-103
gb|ABN08537.1| Pyruvate carboxyltransferase [Medicago trunc... 377 e-103
ref|XP_638884.1| hydroxymethylglutaryl-CoA lyase [Dictyoste... 377 e-103
ref|ZP_00056425.1| COG0119: Isopropylmalate/homocitrate/cit... 372 e-101
ref|XP_001843753.1| hydroxymethylglutaryl-CoA lyase [Culex ... 372 e-101
ref|YP_283315.1| Pyruvate carboxyltransferase [Dechloromona... 371 e-101
gb|EEJ81164.1| hydroxymethylglutaryl-CoA lyase [Kangiella k... 370 e-100
ref|ZP_01076043.1| 3-hydroxymethylglutaryl-CoA or malyl-CoA... 369 e-100
ref|XP_001771511.1| predicted protein [Physcomitrella paten... 367 e-100
ref|ZP_01899775.1| Hydroxymethylglutaryl-CoA lyase [Moritel... 367 e-100
ref|YP_001502656.1| pyruvate carboxyltransferase [Shewanell... 365 2e-99
ref|YP_268341.1| hydroxymethylglutaryl-CoA lyase [Colwellia... 364 5e-99
ref|YP_001187522.1| hydroxymethylglutaryl-CoA lyase [Pseudo... 364 6e-99
ref|YP_662491.1| pyruvate carboxyltransferase [Pseudoaltero... 364 6e-99
ref|ZP_02157638.1| hydroxymethylglutaryl-CoA lyase [Shewane... 363 7e-99
ref|YP_001473193.1| pyruvate carboxyltransferase [Shewanell... 362 2e-98
ref|ZP_01308647.1| hydroxymethylglutaryl-CoA lyase [Oceanob... 362 2e-98
gb|EAW95097.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A ... 362 2e-98
ref|YP_959392.1| pyruvate carboxyltransferase [Marinobacter... 361 4e-98
ref|YP_001675115.1| pyruvate carboxyltransferase [Shewanell... 360 6e-98
ref|ZP_00974724.1| COG0119: Isopropylmalate/homocitrate/cit... 360 7e-98
ref|YP_001094699.1| pyruvate carboxyltransferase [Shewanell... 360 7e-98
ref|YP_420036.1| Isopropylmalate/homocitrate/citramalate sy... 360 7e-98
emb|CAI40662.1| novel protein similar to 3-hydroxymethyl-3-... 360 7e-98
ref|YP_001173695.1| hydroxymethylglutaryl-CoA lyase [Pseudo... 360 9e-98
emb|CAK32536.1| Hydroxymethylglutaryl-CoA lyase [uncultured... 360 1e-97
ref|ZP_00417242.1| HMG-CoA lyase-like [Azotobacter vineland... 359 1e-97
ref|ZP_01738810.1| 3-hydroxymethylglutaryl-CoA or malyl-CoA... 359 1e-97
ref|ZP_01617610.1| hydroxymethylglutaryl-CoA lyase [marine ... 358 4e-97
ref|YP_159665.1| 3-hydroxymethylglutaryl-CoA or malyl-CoA l... 358 4e-97
ref|ZP_01894930.1| 3-hydroxymethylglutaryl-CoA or malyl-CoA... 358 4e-97
ref|YP_001761592.1| pyruvate carboxyltransferase [Shewanell... 358 4e-97
ref|XP_001770817.1| predicted protein [Physcomitrella paten... 356 1e-96
emb|CAM76025.1| Pyruvate carboxyltransferase [Magnetospiril... 356 1e-96
ref|YP_001668619.1| pyruvate carboxyltransferase [Pseudomon... 356 1e-96
ref|XP_001025212.1| HMGL-like family protein [Tetrahymena t... 355 3e-96
ref|ZP_01128907.1| Pyruvate carboxyltransferase [Nitrococcu... 355 3e-96
ref|YP_343884.1| Pyruvate carboxyltransferase [Nitrosococcu... 354 5e-96
ref|YP_927235.1| pyruvate carboxyltransferase [Shewanella a... 354 6e-96
ref|ZP_01165306.1| Pyruvate carboxyltransferase [Oceanospir... 354 7e-96
ref|YP_934568.1| hydroxymethylglutaryl-CoA lyase [Azoarcus ... 353 7e-96
ref|ZP_02842380.1| pyruvate carboxyltransferase [Thauera sp... 353 7e-96
ref|YP_261034.1| hydroxymethylglutaryl-CoA lyase [Pseudomon... 353 8e-96
ref|YP_001267557.1| hydroxymethylglutaryl-CoA lyase [Pseudo... 353 8e-96
ref|XP_001426433.1| hypothetical protein GSPATT00029666001 ... 352 1e-95
ref|ZP_00969554.1| COG0119: Isopropylmalate/homocitrate/cit... 352 2e-95
pdb|2FTP|A Chain A, Crystal Structure Of Hydroxymethylgluta... 352 2e-95
ref|YP_001555403.1| pyruvate carboxyltransferase [Shewanell... 352 2e-95
ref|NP_250701.1| hydroxymethylglutaryl-CoA lyase [Pseudomon... 352 2e-95
ref|YP_001051186.1| pyruvate carboxyltransferase [Shewanell... 352 3e-95
ref|YP_001348638.1| hydroxymethylglutaryl-CoA lyase [Pseudo... 352 3e-95
ref|NP_745677.1| hydroxymethylglutaryl-CoA lyase [Pseudomon... 351 5e-95
gb|AAT51198.1| PA2011 [synthetic construct] 350 7e-95
ref|ZP_01840459.1| pyruvate carboxyltransferase [Shewanella... 350 7e-95
ref|YP_563253.1| Hydroxymethylglutaryl-CoA lyase [Shewanell... 350 9e-95
ref|YP_001748815.1| pyruvate carboxyltransferase [Pseudomon... 348 3e-94
ref|ZP_00975701.1| COG0119: Isopropylmalate/homocitrate/cit... 348 3e-94
ref|YP_001367047.1| pyruvate carboxyltransferase [Shewanell... 348 4e-94
ref|YP_294379.1| hydroxymethylglutaryl-CoA lyase [Ralstonia... 348 4e-94
ref|YP_738441.1| pyruvate carboxyltransferase [Shewanella s... 347 9e-94
ref|XP_973049.1| PREDICTED: similar to CG10399-PA [Triboliu... 347 9e-94
ref|YP_274820.1| hydroxymethylglutaryl-CoA lyase [Pseudomon... 347 1e-93
ref|YP_751410.1| pyruvate carboxyltransferase [Shewanella f... 346 1e-93
ref|NP_792548.1| hydroxymethylglutaryl-CoA lyase [Pseudomon... 346 1e-93
ref|YP_608548.1| hydroxymethylglutaryl-CoA lyase [Pseudomon... 346 2e-93
ref|YP_001424886.1| hydroxymethylglutaryl-CoA lyase [Coxiel... 345 2e-93
ref|YP_155267.1| Hydroxymethylglutaryl-CoA lyase [Idiomarin... 345 3e-93
ref|YP_235548.1| hydroxymethylglutaryl-CoA lyase [Pseudomon... 345 3e-93
ref|YP_001633348.1| hydroxymethylglutaryl-CoA lyase [Bordet... 345 3e-93
ref|ZP_01946497.2| hydroxymethylglutaryl-CoA lyase [Coxiell... 345 3e-93
ref|YP_349383.1| hydroxymethylglutaryl-CoA lyase [Pseudomon... 345 4e-93
ref|YP_001524912.1| hydroxymethylglutaryl-CoA lyase [Azorhi... 345 4e-93
ref|ZP_01707035.1| pyruvate carboxyltransferase [Shewanella... 344 5e-93
ref|YP_869307.1| pyruvate carboxyltransferase [Shewanella s... 344 7e-93
ref|NP_800125.1| hydroxymethylglutaryl-CoA lyase [Vibrio pa... 343 7e-93
ref|YP_734454.1| pyruvate carboxyltransferase [Shewanella s... 343 8e-93
ref|YP_001416756.1| pyruvate carboxyltransferase [Xanthobac... 343 1e-92
ref|ZP_01102127.1| hydroxymethylglutaryl-CoA lyase [gamma p... 343 1e-92
ref|YP_963688.1| pyruvate carboxyltransferase [Shewanella s... 343 1e-92
ref|NP_819552.1| hydroxymethylglutaryl-CoA lyase [Coxiella ... 342 2e-92
ref|YP_001596451.1| hydroxymethylglutaryl-CoA lyase [Coxiel... 342 3e-92
ref|ZP_01043050.1| Hydroxymethylglutaryl-CoA lyase [Idiomar... 342 3e-92
ref|NP_717501.1| hydroxymethylglutaryl-CoA lyase [Shewanell... 342 3e-92
ref|YP_525054.1| pyruvate carboxyltransferase [Rhodoferax f... 341 6e-92
ref|ZP_01990241.1| hydroxymethylglutaryl-CoA lyase [Vibrio ... 340 6e-92
ref|XP_001703205.1| hypothetical protein CHLREDRAFT_195057 ... 340 6e-92
ref|ZP_01475929.1| hypothetical protein VEx2w_02001435 [Vib... 340 7e-92
emb|CAG09421.1| unnamed protein product [Tetraodon nigrovir... 340 1e-91
ref|NP_001040133.1| hydroxymethylglutaryl-CoA lyase [Bombyx... 339 1e-91
ref|YP_001183239.1| pyruvate carboxyltransferase [Shewanell... 339 2e-91
ref|ZP_01112572.1| hydroxymethylglutaryl-CoA lyase [Reineke... 338 2e-91
ref|YP_386231.1| Pyruvate carboxyltransferase [Geobacter me... 338 2e-91
ref|YP_980720.1| pyruvate carboxyltransferase [Polaromonas ... 338 3e-91
ref|YP_550945.1| pyruvate carboxyltransferase [Polaromonas ... 338 3e-91
ref|YP_582762.1| hydroxymethylglutaryl-CoA lyase [Ralstonia... 338 4e-91
ref|ZP_01219333.1| putative hydroxymethylglutaryl-CoA lyase... 338 4e-91
ref|ZP_01109008.1| hydroxymethylglutaryl-CoA lyase [Alterom... 337 6e-91
ref|YP_001447608.1| hydroxymethylglutaryl-CoA lyase [Vibrio... 337 7e-91
ref|ZP_02194290.1| hydroxymethylglutaryl-CoA lyase [Vibrio ... 337 8e-91
ref|YP_127132.1| hypothetical protein lpl1794 [Legionella p... 337 9e-91
ref|YP_987942.1| pyruvate carboxyltransferase [Acidovorax s... 337 1e-90
ref|YP_132791.1| putative hydroxymethylglutaryl-CoA lyase [... 337 1e-90
ref|YP_095856.1| hydroxymethylglutaryl-CoA lyase [Legionell... 336 1e-90
ref|YP_001250583.1| hydroxymethylglutaryl-CoA lyase [Legion... 336 2e-90
ref|NP_642177.1| hydroxymethylglutaryl-CoA lyase [Xanthomon... 335 2e-90
ref|XP_501226.1| hypothetical protein [Yarrowia lipolytica]... 335 3e-90
ref|ZP_00946303.1| Hydroxymethylglutaryl-CoA lyase [Ralston... 335 3e-90
ref|YP_784735.1| hydroxymethylglutaryl-CoA lyase [Bordetell... 335 3e-90
ref|ZP_01260765.1| hydroxymethylglutaryl-CoA lyase [Vibrio ... 335 4e-90
ref|ZP_01644741.1| pyruvate carboxyltransferase [Stenotroph... 335 4e-90
ref|YP_972663.1| pyruvate carboxyltransferase [Acidovorax a... 334 7e-90
ref|NP_800639.1| putative hydroxymethylglutaryl-CoA lyase [... 333 7e-90
ref|ZP_01985852.1| hydroxymethylglutaryl-CoA lyase [Vibrio ... 333 7e-90
ref|YP_001766260.1| pyruvate carboxyltransferase [Burkholde... 333 9e-90
ref|ZP_01522450.1| pyruvate carboxyltransferase [Comamonas ... 333 9e-90
ref|YP_001903524.1| Hydroxymethylglutaryl-CoA lyase [Xantho... 333 9e-90
ref|YP_001809562.1| pyruvate carboxyltransferase [Burkholde... 333 1e-89
ref|YP_370547.1| hydroxymethylglutaryl-CoA lyase [Burkholde... 333 1e-89
ref|ZP_02893054.1| pyruvate carboxyltransferase [Burkholder... 333 1e-89
ref|ZP_02911146.1| pyruvate carboxyltransferase [Burkholder... 332 2e-89
ref|YP_774897.1| hydroxymethylglutaryl-CoA lyase [Burkholde... 332 2e-89
ref|ZP_00980803.1| COG0119: Isopropylmalate/homocitrate/cit... 332 2e-89
ref|YP_001856404.1| pyruvate carboxyltransferase [Burkholde... 332 2e-89
ref|ZP_01989357.1| hydroxymethylglutaryl-CoA lyase [Vibrio ... 332 2e-89
ref|YP_001566977.1| pyruvate carboxyltransferase [Delftia a... 332 3e-89
ref|YP_622219.1| hydroxymethylglutaryl-CoA lyase [Burkholde... 332 3e-89
ref|ZP_00987697.1| COG0119: Isopropylmalate/homocitrate/cit... 332 3e-89
ref|ZP_02377633.1| hydroxymethylglutaryl-CoA lyase [Burkhol... 332 3e-89
ref|YP_001581136.1| pyruvate carboxyltransferase [Burkholde... 332 3e-89
ref|YP_001894089.1| pyruvate carboxyltransferase [Burkholde... 331 5e-89
ref|YP_001120874.1| hydroxymethylglutaryl-CoA lyase [Burkho... 330 6e-89
ref|YP_001897709.1| pyruvate carboxyltransferase [Ralstonia... 330 7e-89
ref|ZP_02006287.1| pyruvate carboxyltransferase [Ralstonia ... 330 7e-89
ref|YP_363628.1| hydroxymethylglutaryl-CoA lyase [Xanthomon... 330 1e-88
ref|ZP_01614249.1| Hydroxymethylglutaryl-CoA lyase (HMG-CoA... 330 1e-88
ref|YP_001795524.1| HYDROXYMETHYLGLUTARYL-COA LYASE PROTEIN... 328 3e-88
ref|YP_339966.1| Hydroxymethylglutaryl-CoA lyase (HMG-CoA l... 328 4e-88
ref|NP_882598.1| hydroxymethylglutaryl-CoA lyase [Bordetell... 328 4e-88
ref|NP_879404.1| hydroxymethylglutaryl-CoA lyase [Bordetell... 328 5e-88
ref|NP_637197.1| hydroxymethylglutaryl-CoA lyase [Xanthomon... 327 5e-88
ref|ZP_02882797.1| pyruvate carboxyltransferase [Burkholder... 327 7e-88
ref|ZP_01869471.1| putative hydroxymethylglutaryl-CoA lyase... 327 7e-88
ref|XP_001122226.1| PREDICTED: similar to CG10399-PA [Apis ... 327 7e-88
ref|YP_001280953.1| pyruvate carboxyltransferase [Psychroba... 327 9e-88
ref|ZP_01477180.1| hypothetical protein VEx2w_02000016 [Vib... 326 1e-87
ref|ZP_02462060.1| hydroxymethylglutaryl-CoA lyase [Burkhol... 326 2e-87
gb|AAB50182.1| 3-hydroxy-3-methylglutaryl-CoA lyase 326 2e-87
ref|NP_518382.1| hydroxymethylglutaryl-CoA lyase [Ralstonia... 325 2e-87
ref|YP_724706.1| hydroxymethylglutaryl-CoA lyase [Ralstonia... 325 2e-87
ref|ZP_01260030.1| putative hydroxymethylglutaryl-CoA lyase... 325 2e-87
ref|YP_106960.1| hydroxymethylglutaryl-CoA lyase [Burkholde... 325 3e-87
ref|YP_001351814.1| hydroxymethylglutaryl-CoA lyase [Janthi... 325 4e-87
ref|YP_440871.1| hydroxymethylglutaryl-CoA lyase [Burkholde... 325 4e-87
ref|YP_556781.1| hydroxymethylglutaryl-CoA lyase [Burkholde... 324 6e-87
ref|ZP_02354193.1| hydroxymethylglutaryl-CoA lyase [Burkhol... 324 6e-87
ref|YP_001846066.1| Isopropylmalate/homocitrate/citramalate... 323 8e-87
ref|ZP_02372445.1| hydroxymethylglutaryl-CoA lyase [Burkhol... 323 8e-87
ref|YP_001714131.1| putative Hydroxymethylglutaryl-CoA lyas... 323 1e-86
ref|YP_001791147.1| pyruvate carboxyltransferase [Leptothri... 323 1e-86
ref|NP_490889.1| Y71G12B.10 [Caenorhabditis elegans] >gi|14... 323 2e-86
ref|ZP_01224251.1| hydroxymethylglutaryl-CoA lyase [marine ... 322 2e-86
dbj|BAC87045.1| unnamed protein product [Homo sapiens] 321 4e-86
ref|XP_001606475.1| PREDICTED: similar to hydroxymethylglut... 320 8e-86
ref|ZP_03824456.1| hydroxymethylglutaryl-CoA lyase (3-hydro... 320 1e-85
ref|YP_001205681.1| hydroxymethylglutaryl-CoA lyase (HMG-Co... 320 1e-85
ref|YP_001240021.1| hydroxymethylglutaryl-CoA lyase [Bradyr... 319 1e-85
ref|ZP_01133898.1| Hydroxymethylglutaryl-CoA lyase (HMG-CoA... 319 2e-85
ref|ZP_02243134.1| hydroxymethylglutaryl-CoA lyase [Xanthom... 319 2e-85
ref|NP_901429.1| hydroxymethylglutaryl-CoA lyase [Chromobac... 318 3e-85
ref|YP_995316.1| pyruvate carboxyltransferase [Verminephrob... 318 3e-85
ref|YP_295676.1| hydroxymethylglutaryl-CoA lyase [Ralstonia... 318 3e-85
ref|NP_937105.1| putative hydroxymethylglutaryl-CoA lyase [... 318 4e-85
ref|YP_451782.1| hydroxymethylglutaryl-CoA lyase [Xanthomon... 317 5e-85
ref|ZP_01766709.1| hydroxymethylglutaryl-CoA lyase [Burkhol... 317 5e-85
ref|XP_001667667.1| Hypothetical protein CBG22170 [Caenorha... 317 1e-84
ref|YP_263616.1| probable hydroxymethylglutaryl-coenzyme A ... 317 1e-84
ref|NP_357129.2| hydroxymethylglutaryl-CoA lyase [Agrobacte... 316 2e-84
ref|YP_001022542.1| hydroxymethylglutaryl-CoA lyase [Methyl... 315 3e-84
ref|YP_579611.1| pyruvate carboxyltransferase [Psychrobacte... 314 5e-84
ref|YP_435092.1| Isopropylmalate/homocitrate/citramalate sy... 313 9e-84
ref|NP_771062.1| hydroxymethylglutaryl-CoA lyase [Bradyrhiz... 313 1e-83
ref|YP_781827.1| pyruvate carboxyltransferase [Rhodopseudom... 313 2e-83
ref|ZP_01233364.1| putative hydroxymethylglutaryl-CoA lyase... 311 4e-83
ref|ZP_01913861.1| hydroxymethylglutaryl-CoA lyase [Limnoba... 311 6e-83
ref|ZP_01159378.1| putative hydroxymethylglutaryl-CoA lyase... 310 9e-83
ref|YP_532647.1| pyruvate carboxyltransferase [Rhodopseudom... 309 2e-82
ref|ZP_02912623.1| pyruvate carboxyltransferase [Geobacillu... 309 2e-82
ref|YP_486545.1| Pyruvate carboxyltransferase [Rhodopseudom... 309 2e-82
ref|YP_427027.1| Pyruvate carboxyltransferase [Rhodospirill... 308 3e-82
ref|YP_201542.1| hydroxymethylglutaryl-CoA lyase [Xanthomon... 307 6e-82
ref|YP_002796051.1| Hydroxymethylglutaryl-CoA lyase [Lariba... 304 5e-81
ref|ZP_03862034.1| hydroxymethylglutaryl-CoA lyase [Kribbel... 303 2e-80
ref|YP_569667.1| pyruvate carboxyltransferase [Rhodopseudom... 302 3e-80
ref|YP_001108593.1| hydroxymethylglutaryl-CoA lyase [Saccha... 301 4e-80
ref|ZP_01903105.1| hydroxymethylglutaryl-CoA lyase [Roseoba... 300 1e-79
ref|YP_001141730.1| hydroxymethylglutaryl-CoA lyase [Aeromo... 299 2e-79
ref|ZP_01723191.1| hydroxymethylglutaryl-CoA lyase [Bacillu... 298 3e-79
ref|ZP_03817872.1| hydroxymethylglutaryl-CoA lyase [Actinos... 298 4e-79
ref|YP_001696645.1| Hydroxymethylglutaryl-CoA lyase [Lysini... 298 5e-79
ref|NP_947882.1| 3-hydroxy-3-methylglutaryl-CoA lyase [Rhod... 298 5e-79
ref|ZP_02299082.1| pyruvate carboxyltransferase [Rhodopseud... 298 5e-79
ref|YP_167995.1| hydroxymethylglutaryl-CoA lyase [Silicibac... 298 5e-79
ref|YP_001125565.1| hydroxymethylglutaryl-CoA lyase [Geobac... 298 5e-79
ref|ZP_01034319.1| hydroxymethylglutaryl-CoA lyase [Roseova... 297 8e-79
ref|ZP_01549388.1| hydroxymethylglutaryl-CoA lyase [Stappia... 297 9e-79
gb|EDP48120.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A ... 296 1e-78
ref|NP_826453.1| hydroxymethylglutaryl-CoA lyase [Streptomy... 296 2e-78
ref|ZP_02153553.1| hydroxymethylglutaryl-CoA lyase [Oceanib... 296 2e-78
ref|YP_147454.1| hydroxymethylglutaryl-CoA lyase [Geobacill... 295 3e-78
ref|YP_001313269.1| hydroxymethylglutaryl-CoA lyase [Sinorh... 295 5e-78
ref|XP_746760.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme ... 294 6e-78
ref|ZP_01014318.1| hydroxymethylglutaryl-CoA lyase [Rhodoba... 294 7e-78
ref|ZP_00955139.1| hydroxymethylglutaryl-CoA lyase [Sulfito... 293 9e-78
ref|ZP_00962638.1| hydroxymethylglutaryl-CoA lyase [Sulfito... 293 1e-77
ref|YP_001368600.1| Hydroxymethylglutaryl-CoA lyase [Ochrob... 293 1e-77
ref|YP_856604.1| hydroxymethylglutaryl-CoA lyase [Aeromonas... 293 1e-77
ref|YP_612734.1| hydroxymethylglutaryl-CoA lyase [Silicibac... 293 1e-77
ref|ZP_01225781.1| hydroxymethylglutaryl-CoA lyase [Auranti... 291 5e-77
sp|P13703|HMGCL_PSEMV Hydroxymethylglutaryl-CoA lyase (HMG-... 291 6e-77
ref|NP_437244.1| hydroxymethylglutaryl-CoA lyase [Sinorhizo... 291 6e-77
ref|ZP_01056180.1| hydroxymethylglutaryl-CoA lyase [Roseoba... 290 8e-77
ref|YP_001268386.1| pyruvate carboxyltransferase [Pseudomon... 290 1e-76
ref|ZP_01756061.1| hydroxymethylglutaryl-CoA lyase [Roseoba... 290 1e-76
ref|YP_002823370.1| hydroxymethylglutaryl-CoA lyase [Rhizob... 289 2e-76
ref|ZP_01443900.1| hydroxymethylglutaryl-CoA lyase [Roseova... 288 3e-76
ref|YP_001614964.1| Hydroxymethylglutaryl-CoA lyase [Sorang... 288 5e-76
ref|NP_711026.1| Hydroxymethylglutaryl-CoA lyase [Leptospir... 288 6e-76
ref|ZP_00631474.1| Hydroxymethylglutaryl-CoA lyase [Paracoc... 287 9e-76
ref|ZP_01745356.1| hydroxymethylglutaryl-CoA lyase [Sagittu... 287 9e-76
ref|XP_001825445.1| hypothetical protein [Aspergillus oryza... 286 1e-75
ref|YP_001098468.1| putative hydroxymethylglutaryl-CoA lyas... 286 1e-75
ref|YP_799007.1| 2-isopropylmalate synthase [Leptospira bor... 286 1e-75
ref|YP_001532646.1| Hydroxymethylglutaryl-CoA lyase [Dinoro... 286 2e-75
gb|AAD20054.1| Unknown [Homo sapiens] 285 3e-75
ref|YP_631935.1| hydroxymethylglutaryl-CoA lyase [Myxococcu... 285 4e-75
gb|EDL80780.1| 3-hydroxy-3-methylglutaryl-Coenzyme A lyase,... 284 8e-75
ref|NP_540843.1| hydroxymethylglutaryl-CoA lyase [Brucella ... 282 2e-74
ref|ZP_01696476.1| pyruvate carboxyltransferase [Bacillus c... 282 2e-74
>ref|NP_000182.2| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase
(hydroxymethylglutaricaciduria) [Homo sapiens]
sp|P35914|HMGCL_HUMAN Hydroxymethylglutaryl-CoA lyase, mitochondrial precursor (HMG-CoA
lyase) (HL) (3-hydroxy-3-methylglutarate-CoA lyase)
gb|AAH10570.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase
(hydroxymethylglutaricaciduria) [Homo sapiens]
gb|AAP88794.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase
(hydroxymethylglutaricaciduria) [Homo sapiens]
emb|CAG33165.1| HMGCL [Homo sapiens]
gb|AAX31956.1| 3-hydroxymethyl-3-methylglutaryl-coenzyme A lyase [synthetic
construct]
gb|AAX31957.1| 3-hydroxymethyl-3-methylglutaryl-coenzyme A lyase [synthetic
construct]
gb|AAX31958.1| 3-hydroxymethyl-3-methylglutaryl-coenzyme A lyase [synthetic
construct]
gb|AAX31959.1| 3-hydroxymethyl-3-methylglutaryl-coenzyme A lyase [synthetic
construct]
gb|EAW95094.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase
(hydroxymethylglutaricaciduria), isoform CRA_a [Homo
sapiens]
gb|ABM83009.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase
(hydroxymethylglutaricaciduria) [synthetic construct]
gb|ABM86202.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase
(hydroxymethylglutaricaciduria) [synthetic construct]
Length = 325
Score = 624 bits (1610), Expect = e-177, Method: Composition-based stats.
Identities = 325/325 (100%), Positives = 325/325 (100%)
Query: 1 MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI
Sbjct: 1 MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
Query: 61 DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAG 120
DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAG
Sbjct: 61 DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAG 120
Query: 121 AKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
AKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI
Sbjct: 121 AKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
Query: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ
Sbjct: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
Query: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL
Sbjct: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
Query: 301 EAGNFICQALNRKTSSKVAQATCKL 325
EAGNFICQALNRKTSSKVAQATCKL
Sbjct: 301 EAGNFICQALNRKTSSKVAQATCKL 325
>ref|XP_001166273.1| PREDICTED: 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase
(hydroxymethylglutaricaciduria) isoform 3 [Pan
troglodytes]
Length = 325
Score = 624 bits (1608), Expect = e-177, Method: Composition-based stats.
Identities = 324/325 (99%), Positives = 325/325 (100%)
Query: 1 MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKL+
Sbjct: 1 MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLV 60
Query: 61 DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAG 120
DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAG
Sbjct: 61 DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAG 120
Query: 121 AKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
AKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI
Sbjct: 121 AKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
Query: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ
Sbjct: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
Query: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL
Sbjct: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
Query: 301 EAGNFICQALNRKTSSKVAQATCKL 325
EAGNFICQALNRKTSSKVAQATCKL
Sbjct: 301 EAGNFICQALNRKTSSKVAQATCKL 325
>gb|AAA92733.1| hydroxymethylglutaryl-CoA lyase [Homo sapiens]
Length = 325
Score = 623 bits (1607), Expect = e-177, Method: Composition-based stats.
Identities = 324/325 (99%), Positives = 324/325 (99%)
Query: 1 MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI
Sbjct: 1 MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
Query: 61 DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAG 120
DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAG
Sbjct: 61 DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAG 120
Query: 121 AKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
AKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI
Sbjct: 121 AKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
Query: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ
Sbjct: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
Query: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
AL NTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL
Sbjct: 241 ALTNTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
Query: 301 EAGNFICQALNRKTSSKVAQATCKL 325
EAGNFICQALNRKTSSKVAQATCKL
Sbjct: 301 EAGNFICQALNRKTSSKVAQATCKL 325
>sp|Q5R9E1|HMGCL_PONPY Hydroxymethylglutaryl-CoA lyase, mitochondrial precursor (HMG-CoA
lyase) (HL) (3-hydroxy-3-methylglutarate-CoA lyase)
emb|CAH91619.1| hypothetical protein [Pongo abelii]
Length = 325
Score = 613 bits (1581), Expect = e-174, Method: Composition-based stats.
Identities = 321/325 (98%), Positives = 322/325 (99%)
Query: 1 MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
MAAMRKA+PRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI
Sbjct: 1 MAAMRKAVPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
Query: 61 DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAG 120
DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAG
Sbjct: 61 DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAG 120
Query: 121 AKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
AKEV IFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI
Sbjct: 121 AKEVAIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
Query: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
SPAKVAEVTKK YSMGCYEISLGDTIGVGTPGIMK MLSAVMQEVPLAALAVHCHDTYGQ
Sbjct: 181 SPAKVAEVTKKLYSMGCYEISLGDTIGVGTPGIMKGMLSAVMQEVPLAALAVHCHDTYGQ 240
Query: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL
Sbjct: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
Query: 301 EAGNFICQALNRKTSSKVAQATCKL 325
EAGNFICQALNRKTSSKVAQATCKL
Sbjct: 301 EAGNFICQALNRKTSSKVAQATCKL 325
>sp|Q8HXZ6|HMGCL_MACFA Hydroxymethylglutaryl-CoA lyase, mitochondrial precursor (HMG-CoA
lyase) (HL) (3-hydroxy-3-methylglutarate-CoA lyase)
dbj|BAC20595.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase [Macaca
fascicularis]
Length = 325
Score = 598 bits (1543), Expect = e-169, Method: Composition-based stats.
Identities = 313/325 (96%), Positives = 315/325 (96%)
Query: 1 MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
MAAM KALPRRLVGLASLRAVSTSSM TLPK+VKIVEVGPRDGLQNEKNIVSTPVKIKLI
Sbjct: 1 MAAMTKALPRRLVGLASLRAVSTSSMDTLPKQVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
Query: 61 DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAG 120
DMLSEAGLSVIE TSFVSPKWVPQM DH EVLKGIQKFPGI YPVL PNLKGFEAAVAAG
Sbjct: 61 DMLSEAGLSVIEATSFVSPKWVPQMADHAEVLKGIQKFPGITYPVLIPNLKGFEAAVAAG 120
Query: 121 AKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
AKEV IFGAASELFTKKN+NCSIEESFQRFDAILKAAQSANISVRGYVSC LGCPYEGKI
Sbjct: 121 AKEVSIFGAASELFTKKNVNCSIEESFQRFDAILKAAQSANISVRGYVSCVLGCPYEGKI 180
Query: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVP AALAVHCHDTYGQ
Sbjct: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPPAALAVHCHDTYGQ 240
Query: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL
Sbjct: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
Query: 301 EAGNFICQALNRKTSSKVAQATCKL 325
EAGNFICQALNRKTSSKVAQATCKL
Sbjct: 301 EAGNFICQALNRKTSSKVAQATCKL 325
>dbj|BAE88248.1| unnamed protein product [Macaca fascicularis]
Length = 325
Score = 595 bits (1533), Expect = e-168, Method: Composition-based stats.
Identities = 312/325 (96%), Positives = 314/325 (96%)
Query: 1 MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
MAAM KALPRRLVGLASLRAVSTSSM TLPK+VKIVEVGPRDGLQN+KNIVSTPVKIKLI
Sbjct: 1 MAAMTKALPRRLVGLASLRAVSTSSMDTLPKQVKIVEVGPRDGLQNKKNIVSTPVKIKLI 60
Query: 61 DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAG 120
DMLSEAGLSVIE TSFVSPKWVPQM DH EVLKGIQKFPGI YPVL PNLKGFEAAVAAG
Sbjct: 61 DMLSEAGLSVIEATSFVSPKWVPQMADHAEVLKGIQKFPGITYPVLIPNLKGFEAAVAAG 120
Query: 121 AKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
AKEV IFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSC LGCPYEGKI
Sbjct: 121 AKEVSIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCVLGCPYEGKI 180
Query: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVP AALAVHCHDTYGQ
Sbjct: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPPAALAVHCHDTYGQ 240
Query: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQK L
Sbjct: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKPL 300
Query: 301 EAGNFICQALNRKTSSKVAQATCKL 325
EAGNFICQALNRKTSSKVAQATCKL
Sbjct: 301 EAGNFICQALNRKTSSKVAQATCKL 325
>ref|XP_513200.2| PREDICTED: similar to 3-hydroxymethyl-3-methylglutaryl-Coenzyme A
lyase (hydroxymethylglutaricaciduria) isoform 4 [Pan
troglodytes]
Length = 316
Score = 590 bits (1520), Expect = e-167, Method: Composition-based stats.
Identities = 304/305 (99%), Positives = 305/305 (100%)
Query: 21 VSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPK 80
VSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKL+DMLSEAGLSVIETTSFVSPK
Sbjct: 12 VSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLVDMLSEAGLSVIETTSFVSPK 71
Query: 81 WVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNIN 140
WVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNIN
Sbjct: 72 WVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNIN 131
Query: 141 CSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEI 200
CSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEI
Sbjct: 132 CSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEI 191
Query: 201 SLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSV 260
SLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSV
Sbjct: 192 SLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSV 251
Query: 261 AGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQ 320
AGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQ
Sbjct: 252 AGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQ 311
Query: 321 ATCKL 325
ATCKL
Sbjct: 312 ATCKL 316
>gb|AAB19099.1| hydroxymethylglutaryl-CoA lyase
Length = 305
Score = 587 bits (1512), Expect = e-166, Method: Composition-based stats.
Identities = 304/305 (99%), Positives = 305/305 (100%)
Query: 21 VSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPK 80
VSTSSMGTLPKRVKIVEVGP+DGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPK
Sbjct: 1 VSTSSMGTLPKRVKIVEVGPQDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPK 60
Query: 81 WVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNIN 140
WVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNIN
Sbjct: 61 WVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNIN 120
Query: 141 CSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEI 200
CSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEI
Sbjct: 121 CSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEI 180
Query: 201 SLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSV 260
SLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSV
Sbjct: 181 SLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSV 240
Query: 261 AGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQ 320
AGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQ
Sbjct: 241 AGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQ 300
Query: 321 ATCKL 325
ATCKL
Sbjct: 301 ATCKL 305
>emb|CAI23161.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase
(hydroxymethylglutaricaciduria) [Homo sapiens]
gb|EAW95095.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase
(hydroxymethylglutaricaciduria), isoform CRA_b [Homo
sapiens]
Length = 300
Score = 583 bits (1503), Expect = e-165, Method: Composition-based stats.
Identities = 300/300 (100%), Positives = 300/300 (100%)
Query: 26 MGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQM 85
MGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQM
Sbjct: 1 MGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQM 60
Query: 86 GDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNINCSIEE 145
GDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNINCSIEE
Sbjct: 61 GDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNINCSIEE 120
Query: 146 SFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLGDT 205
SFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLGDT
Sbjct: 121 SFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLGDT 180
Query: 206 IGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGG 265
IGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGG
Sbjct: 181 IGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGG 240
Query: 266 CPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQATCKL 325
CPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQATCKL
Sbjct: 241 CPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQATCKL 300
>ref|XP_001166216.1| PREDICTED: similar to 3-hydroxymethyl-3-methylglutaryl-Coenzyme A
lyase (hydroxymethylglutaricaciduria) isoform 2 [Pan
troglodytes]
Length = 300
Score = 582 bits (1500), Expect = e-164, Method: Composition-based stats.
Identities = 299/300 (99%), Positives = 300/300 (100%)
Query: 26 MGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQM 85
MGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKL+DMLSEAGLSVIETTSFVSPKWVPQM
Sbjct: 1 MGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLVDMLSEAGLSVIETTSFVSPKWVPQM 60
Query: 86 GDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNINCSIEE 145
GDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNINCSIEE
Sbjct: 61 GDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNINCSIEE 120
Query: 146 SFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLGDT 205
SFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLGDT
Sbjct: 121 SFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLGDT 180
Query: 206 IGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGG 265
IGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGG
Sbjct: 181 IGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGG 240
Query: 266 CPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQATCKL 325
CPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQATCKL
Sbjct: 241 CPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQATCKL 300
>pdb|2CW6|A Chain A, Crystal Structure Of Human Hmg-Coa Lyase: Insights Into
Catalysis And The Molecular Basis For
Hydroxymethylglutaric Aciduria
pdb|2CW6|B Chain B, Crystal Structure Of Human Hmg-Coa Lyase: Insights Into
Catalysis And The Molecular Basis For
Hydroxymethylglutaric Aciduria
pdb|2CW6|C Chain C, Crystal Structure Of Human Hmg-Coa Lyase: Insights Into
Catalysis And The Molecular Basis For
Hydroxymethylglutaric Aciduria
pdb|2CW6|D Chain D, Crystal Structure Of Human Hmg-Coa Lyase: Insights Into
Catalysis And The Molecular Basis For
Hydroxymethylglutaric Aciduria
pdb|2CW6|E Chain E, Crystal Structure Of Human Hmg-Coa Lyase: Insights Into
Catalysis And The Molecular Basis For
Hydroxymethylglutaric Aciduria
pdb|2CW6|F Chain F, Crystal Structure Of Human Hmg-Coa Lyase: Insights Into
Catalysis And The Molecular Basis For
Hydroxymethylglutaric Aciduria
Length = 298
Score = 580 bits (1494), Expect = e-164, Method: Composition-based stats.
Identities = 298/298 (100%), Positives = 298/298 (100%)
Query: 28 TLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQMGD 87
TLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQMGD
Sbjct: 1 TLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQMGD 60
Query: 88 HTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNINCSIEESF 147
HTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNINCSIEESF
Sbjct: 61 HTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNINCSIEESF 120
Query: 148 QRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLGDTIG 207
QRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLGDTIG
Sbjct: 121 QRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLGDTIG 180
Query: 208 VGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGGCP 267
VGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGGCP
Sbjct: 181 VGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGGCP 240
Query: 268 YAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQATCKL 325
YAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQATCKL
Sbjct: 241 YAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQATCKL 298
>ref|NP_077362.1| 3-hydroxy-3-methylglutaryl-Coenzyme A lyase [Rattus norvegicus]
sp|P97519|HMGCL_RAT Hydroxymethylglutaryl-CoA lyase, mitochondrial precursor (HMG-CoA
lyase) (HL) (3-hydroxy-3-methylglutarate-CoA lyase)
emb|CAA71148.1| 3-hydroxy-3-methylglutaryl CoA lyase [Rattus norvegicus]
gb|AAH61797.1| 3-hydroxy-3-methylglutaryl-Coenzyme A lyase [Rattus norvegicus]
gb|EDL80779.1| 3-hydroxy-3-methylglutaryl-Coenzyme A lyase, isoform CRA_a [Rattus
norvegicus]
Length = 325
Score = 571 bits (1471), Expect = e-161, Method: Composition-based stats.
Identities = 289/325 (88%), Positives = 311/325 (95%)
Query: 1 MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
MA +RKA P+RLVGLASLRA STSSMGTLPKRVKIVEVGPRDGLQNEK+IV TPVKIKLI
Sbjct: 1 MATVRKAFPQRLVGLASLRAASTSSMGTLPKRVKIVEVGPRDGLQNEKSIVPTPVKIKLI 60
Query: 61 DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAG 120
DMLSEAGL VIE TSFVSPKWVPQM DH++VLKGIQKFPGINYPVLTPN+KGFE AVAAG
Sbjct: 61 DMLSEAGLPVIEATSFVSPKWVPQMADHSDVLKGIQKFPGINYPVLTPNMKGFEEAVAAG 120
Query: 121 AKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
AKEV IFGAASELFT+KN+NCSIEESFQRFD +++AA++A+ISVRGYVSCALGCPYEGK+
Sbjct: 121 AKEVSIFGAASELFTRKNVNCSIEESFQRFDGVMQAARAASISVRGYVSCALGCPYEGKV 180
Query: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
SPAKVAEV KK YSMGCYEISLGDTIGVGTPG+MKDML+AV+ EVP+AALAVHCHDTYGQ
Sbjct: 181 SPAKVAEVAKKLYSMGCYEISLGDTIGVGTPGLMKDMLTAVLHEVPVAALAVHCHDTYGQ 240
Query: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
ALANTL+ALQMGVSVVDSSVAGLGGCPYA+GASGNLATEDLVYML GLGIHTGVNLQKLL
Sbjct: 241 ALANTLVALQMGVSVVDSSVAGLGGCPYAKGASGNLATEDLVYMLTGLGIHTGVNLQKLL 300
Query: 301 EAGNFICQALNRKTSSKVAQATCKL 325
EAG+FICQALNRKTSSKVAQATCKL
Sbjct: 301 EAGDFICQALNRKTSSKVAQATCKL 325
>ref|XP_001504254.1| PREDICTED: similar to interleukin 13 receptor alpha 1-binding
protein-1 [Equus caballus]
Length = 325
Score = 569 bits (1466), Expect = e-160, Method: Composition-based stats.
Identities = 296/325 (91%), Positives = 306/325 (94%)
Query: 1 MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
MA +RK LPRRL GLASLRAVSTSS+GT PKRVKIVEVGPRDGLQNEKNIV T +KIKLI
Sbjct: 1 MATVRKGLPRRLAGLASLRAVSTSSVGTFPKRVKIVEVGPRDGLQNEKNIVPTAMKIKLI 60
Query: 61 DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAG 120
DMLSEAGL VIE TSFVSPKWVPQM DHTEVLKGIQKFPGINYPVLTPN KGF+AAVAAG
Sbjct: 61 DMLSEAGLPVIEATSFVSPKWVPQMADHTEVLKGIQKFPGINYPVLTPNFKGFQAAVAAG 120
Query: 121 AKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
AKEV +FGAASELFTKKNINCSIEES QRF +LKAA++A+I VRGYVSCALGCPYEGKI
Sbjct: 121 AKEVAVFGAASELFTKKNINCSIEESIQRFGEVLKAARAASIPVRGYVSCALGCPYEGKI 180
Query: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
SPAKVAEVTKK YSMGCYEISLGDTIGVGTPG MKDMLSAVMQEVP+AALAVHCHDTYGQ
Sbjct: 181 SPAKVAEVTKKMYSMGCYEISLGDTIGVGTPGGMKDMLSAVMQEVPVAALAVHCHDTYGQ 240
Query: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYML GLGIHTGVNLQKLL
Sbjct: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLAGLGIHTGVNLQKLL 300
Query: 301 EAGNFICQALNRKTSSKVAQATCKL 325
EAG FICQALNRKTSSKVAQATCKL
Sbjct: 301 EAGTFICQALNRKTSSKVAQATCKL 325
>ref|NP_001068600.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase
(hydroxymethylglutaricaciduria) [Bos taurus]
sp|Q29448|HMGCL_BOVIN Hydroxymethylglutaryl-CoA lyase, mitochondrial precursor (HMG-CoA
lyase) (HL) (3-hydroxy-3-methylglutarate-CoA lyase)
gb|AAI18277.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase
(hydroxymethylglutaricaciduria) [Bos taurus]
Length = 325
Score = 565 bits (1456), Expect = e-159, Method: Composition-based stats.
Identities = 289/325 (88%), Positives = 305/325 (93%)
Query: 1 MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
MA ++K LPRRLVGLA+LRAVSTSS+GT PK+VKIVEVGPRDGLQNEKNIV TPVKIKLI
Sbjct: 1 MATVKKVLPRRLVGLATLRAVSTSSVGTFPKQVKIVEVGPRDGLQNEKNIVPTPVKIKLI 60
Query: 61 DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAG 120
DMLSEAGL V+E TSFVSPKWVPQM DH EVLKGIQKFPG+NYPVLTPN KGF+AAVAAG
Sbjct: 61 DMLSEAGLPVVEATSFVSPKWVPQMADHAEVLKGIQKFPGVNYPVLTPNFKGFQAAVAAG 120
Query: 121 AKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
AKEV IFGAASELFTKKNINCSI+ES QRFD ILKAA++A ISVRGYVSC LGCPYEGKI
Sbjct: 121 AKEVAIFGAASELFTKKNINCSIDESLQRFDEILKAARAAGISVRGYVSCVLGCPYEGKI 180
Query: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
SPAKVAEVTKK YSMGCYEISLGDTIGVGTPG MKDMLSAV+QEVP+ ALAVHCHDTYGQ
Sbjct: 181 SPAKVAEVTKKLYSMGCYEISLGDTIGVGTPGAMKDMLSAVLQEVPVTALAVHCHDTYGQ 240
Query: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
ALANTL ALQMGVSV+DSSVAGLGGCPYAQGASGNLATEDLVYML GLGIHTGVNLQKLL
Sbjct: 241 ALANTLTALQMGVSVMDSSVAGLGGCPYAQGASGNLATEDLVYMLAGLGIHTGVNLQKLL 300
Query: 301 EAGNFICQALNRKTSSKVAQATCKL 325
EAG FICQALNR+T+SKVAQATCKL
Sbjct: 301 EAGAFICQALNRRTNSKVAQATCKL 325
>ref|NP_032280.2| 3-hydroxy-3-methylglutaryl-Coenzyme A lyase [Mus musculus]
gb|AAH25440.1| Hmgcl protein [Mus musculus]
dbj|BAE32329.1| unnamed protein product [Mus musculus]
dbj|BAE20956.1| unnamed protein product [Mus musculus]
dbj|BAE26328.1| unnamed protein product [Mus musculus]
emb|CAM15901.1| 3-hydroxy-3-methylglutaryl-Coenzyme A lyase [Mus musculus]
gb|EDL29963.1| 3-hydroxy-3-methylglutaryl-Coenzyme A lyase [Mus musculus]
Length = 325
Score = 565 bits (1456), Expect = e-159, Method: Composition-based stats.
Identities = 286/325 (88%), Positives = 308/325 (94%)
Query: 1 MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
MA++RKA PRRLVGL SLRAVSTSSMGTLPK+VKIVEVGPRDGLQNEK+IV TPVKI+LI
Sbjct: 1 MASVRKAFPRRLVGLTSLRAVSTSSMGTLPKQVKIVEVGPRDGLQNEKSIVPTPVKIRLI 60
Query: 61 DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAG 120
DMLSEAGL VIE TSFVSPKWVPQM DH++VLKGIQKFPGINYPVLTPN+KGFE AVAAG
Sbjct: 61 DMLSEAGLPVIEATSFVSPKWVPQMADHSDVLKGIQKFPGINYPVLTPNMKGFEEAVAAG 120
Query: 121 AKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
AKEV +FGA SELFT+KN NCSIEESFQRF +++AAQ+A+ISVRGYVSCALGCPYEGK+
Sbjct: 121 AKEVSVFGAVSELFTRKNANCSIEESFQRFAGVMQAAQAASISVRGYVSCALGCPYEGKV 180
Query: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
SPAKVAEV KK YSMGCYEISLGDTIGVGTPG+MKDML+AVM EVP+ ALAVHCHDTYGQ
Sbjct: 181 SPAKVAEVAKKLYSMGCYEISLGDTIGVGTPGLMKDMLTAVMHEVPVTALAVHCHDTYGQ 240
Query: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
ALANTL+ALQMGVSVVDSSVAGLGGCPYA+GASGNLATEDLVYML GLGIHTGVNLQKLL
Sbjct: 241 ALANTLVALQMGVSVVDSSVAGLGGCPYAKGASGNLATEDLVYMLNGLGIHTGVNLQKLL 300
Query: 301 EAGNFICQALNRKTSSKVAQATCKL 325
EAG+FICQALNRKTSSKVAQATCKL
Sbjct: 301 EAGDFICQALNRKTSSKVAQATCKL 325
>gb|AAB03107.1| 3-hydroxy-3-methylglutaryl-CoA lyase
Length = 325
Score = 562 bits (1449), Expect = e-158, Method: Composition-based stats.
Identities = 284/325 (87%), Positives = 308/325 (94%)
Query: 1 MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
MA++RKA PRRLVGL SLRAVSTSSMGTLPK+VKIVEVGPRDGLQNEK+IV TPVKI+LI
Sbjct: 1 MASVRKAFPRRLVGLTSLRAVSTSSMGTLPKQVKIVEVGPRDGLQNEKSIVPTPVKIRLI 60
Query: 61 DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAG 120
D++SEAGL VIE TSFVSPKWVPQM DH++VLKGIQKFPGINYPVLTPN+KGFE AVAAG
Sbjct: 61 DIVSEAGLPVIEATSFVSPKWVPQMADHSDVLKGIQKFPGINYPVLTPNMKGFEEAVAAG 120
Query: 121 AKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
AKEV +FGA SELFT+KN NCSIEESFQRF +++AAQ+A+ISVRGYVSCALGCPYEGK+
Sbjct: 121 AKEVSVFGAVSELFTRKNANCSIEESFQRFAGVMQAAQAASISVRGYVSCALGCPYEGKV 180
Query: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
SPAKVAEV KK YSMGCYEISLGDTIGVGTPG+MKDML+AVM EVP+ ALAVHCHDTYGQ
Sbjct: 181 SPAKVAEVAKKLYSMGCYEISLGDTIGVGTPGLMKDMLTAVMHEVPVTALAVHCHDTYGQ 240
Query: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
ALANTL+ALQMGVSVVDSSVAGLGGCPYA+GASGNLATEDLVYML GLGIHTGVNLQKLL
Sbjct: 241 ALANTLVALQMGVSVVDSSVAGLGGCPYAKGASGNLATEDLVYMLNGLGIHTGVNLQKLL 300
Query: 301 EAGNFICQALNRKTSSKVAQATCKL 325
EAG+FICQALNRKTSSKVAQATCKL
Sbjct: 301 EAGDFICQALNRKTSSKVAQATCKL 325
>dbj|BAE26056.1| unnamed protein product [Mus musculus]
Length = 325
Score = 560 bits (1443), Expect = e-158, Method: Composition-based stats.
Identities = 284/325 (87%), Positives = 306/325 (94%)
Query: 1 MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
MA++RKA PRRLVGL SLRAVSTSSMGTLPK+VKIVEVGPRDGLQNEK+IV TPVKI+LI
Sbjct: 1 MASVRKAFPRRLVGLTSLRAVSTSSMGTLPKQVKIVEVGPRDGLQNEKSIVPTPVKIRLI 60
Query: 61 DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAG 120
DMLSEAGL VIE TSFVSPKWVPQM DH++VLKGIQKFPGINYPVLTPN+KGFE AVAAG
Sbjct: 61 DMLSEAGLPVIEATSFVSPKWVPQMADHSDVLKGIQKFPGINYPVLTPNMKGFEEAVAAG 120
Query: 121 AKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
AKEV +FGA SELFT+KN NCSIEESFQRF +++AAQ+A+ISVRGYVSCALGCPYEGK+
Sbjct: 121 AKEVSVFGAVSELFTRKNANCSIEESFQRFAGVMQAAQAASISVRGYVSCALGCPYEGKV 180
Query: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
SPAKVAEV KK YSMGCYEISLGDTIGVGTP MKDML+AVM EVP+ ALAVHCHDTYGQ
Sbjct: 181 SPAKVAEVAKKLYSMGCYEISLGDTIGVGTPDXMKDMLTAVMHEVPVTALAVHCHDTYGQ 240
Query: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
ALANTL+ALQMGVSVV+SSVAGLGGCPYA+GASGNLATEDLVYML GLGIHTGVNLQKLL
Sbjct: 241 ALANTLVALQMGVSVVNSSVAGLGGCPYAKGASGNLATEDLVYMLNGLGIHTGVNLQKLL 300
Query: 301 EAGNFICQALNRKTSSKVAQATCKL 325
EAG+FICQALNRKTSSKVAQATCKL
Sbjct: 301 EAGDFICQALNRKTSSKVAQATCKL 325
>sp|P38060|HMGCL_MOUSE Hydroxymethylglutaryl-CoA lyase, mitochondrial precursor (HMG-CoA
lyase) (HL) (3-hydroxy-3-methylglutarate-CoA lyase)
pir||I57009 3-Hydroxy-3-methylglutaryl coenzyme A lyase - mouse
gb|AAB27965.1| 3-Hydroxy-3-methylglutaryl coenzyme A lyase; HL [Mus sp.]
Length = 325
Score = 558 bits (1439), Expect = e-157, Method: Composition-based stats.
Identities = 283/325 (87%), Positives = 305/325 (93%)
Query: 1 MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
MA++RKA PRRLVGL SLRAVSTSSMGTLPK+VKIVEVGPRDGLQNEK+IV TPVKI+LI
Sbjct: 1 MASVRKAFPRRLVGLTSLRAVSTSSMGTLPKQVKIVEVGPRDGLQNEKSIVPTPVKIRLI 60
Query: 61 DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAG 120
DMLSEAGL VIE TSFVSP WVPQM DH++VLKGIQKFPGINYPVLTPN+KGFE AVAAG
Sbjct: 61 DMLSEAGLPVIEATSFVSPNWVPQMADHSDVLKGIQKFPGINYPVLTPNMKGFEEAVAAG 120
Query: 121 AKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
AKEV +FGA SELFT+KN NCSIEESFQRF +++AAQ+A+ISVRGYVSCALGCPYEGK+
Sbjct: 121 AKEVSVFGAVSELFTRKNANCSIEESFQRFAGVMQAAQAASISVRGYVSCALGCPYEGKV 180
Query: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
SPAKVAEV KK YSMGCYEISLGDTIGVGTPG+MKDML+AVM EVP+ AL VHCHDT GQ
Sbjct: 181 SPAKVAEVAKKLYSMGCYEISLGDTIGVGTPGLMKDMLTAVMHEVPVTALGVHCHDTIGQ 240
Query: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
ALANTL+ALQMGVSVVDSSVAGLGGCPYA+GASGNLATEDLVYML GLGIHTGVNLQKLL
Sbjct: 241 ALANTLVALQMGVSVVDSSVAGLGGCPYAKGASGNLATEDLVYMLNGLGIHTGVNLQKLL 300
Query: 301 EAGNFICQALNRKTSSKVAQATCKL 325
EAG+FICQALNRKTSSKVAQATCKL
Sbjct: 301 EAGDFICQALNRKTSSKVAQATCKL 325
>ref|XP_001104722.1| PREDICTED: 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase
(hydroxymethylglutaricaciduria) [Macaca mulatta]
Length = 331
Score = 557 bits (1436), Expect = e-157, Method: Composition-based stats.
Identities = 300/331 (90%), Positives = 302/331 (91%), Gaps = 6/331 (1%)
Query: 1 MAAMRKALPRRLVGLASLRAVSTSS------MGTLPKRVKIVEVGPRDGLQNEKNIVSTP 54
MAAM KALPRRLVGLASLRAVS S GTL RV + V P GL+ NIVSTP
Sbjct: 1 MAAMTKALPRRLVGLASLRAVSAPSRRGGGPAGTLTVRVGSLAVPPEWGLRFLTNIVSTP 60
Query: 55 VKIKLIDMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFE 114
VKIKLIDMLSEAGLSVIE TSFVSPKWVPQM DH EVLKGIQKFPGI YPVL PNLKGFE
Sbjct: 61 VKIKLIDMLSEAGLSVIEATSFVSPKWVPQMADHAEVLKGIQKFPGITYPVLIPNLKGFE 120
Query: 115 AAVAAGAKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGC 174
AAVAAGAKEV IFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSC LGC
Sbjct: 121 AAVAAGAKEVSIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCVLGC 180
Query: 175 PYEGKISPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHC 234
PYEGKISPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVP AALAVHC
Sbjct: 181 PYEGKISPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPPAALAVHC 240
Query: 235 HDTYGQALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGV 294
HDTYGQALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGV
Sbjct: 241 HDTYGQALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGV 300
Query: 295 NLQKLLEAGNFICQALNRKTSSKVAQATCKL 325
NLQKLLEAGNFICQALNRKTSSKVAQATCKL
Sbjct: 301 NLQKLLEAGNFICQALNRKTSSKVAQATCKL 331
>ref|XP_535360.2| PREDICTED: similar to Hydroxymethylglutaryl-CoA lyase,
mitochondrial precursor (HMG-CoA lyase) (HL)
(3-hydroxy-3-methylglutarate-CoA lyase) isoform 1 [Canis
familiaris]
Length = 325
Score = 546 bits (1408), Expect = e-154, Method: Composition-based stats.
Identities = 283/325 (87%), Positives = 295/325 (90%)
Query: 1 MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
MAAMRK +PRRLVGLASLRAVST S+GT PK+VKIVEVG RDGLQNEKNIVST KIKLI
Sbjct: 1 MAAMRKVVPRRLVGLASLRAVSTFSLGTFPKQVKIVEVGARDGLQNEKNIVSTSTKIKLI 60
Query: 61 DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAG 120
DMLSEAGL VIE TSFVSPKWVPQM D EVLKGIQKFPGINYPVLTPN+KGF+AAVAAG
Sbjct: 61 DMLSEAGLPVIEATSFVSPKWVPQMADCAEVLKGIQKFPGINYPVLTPNIKGFQAAVAAG 120
Query: 121 AKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
AKEV IF AASE FTKKN NCSI+E QR D I +AAQ+A I VRGYVSC LGCPYEGKI
Sbjct: 121 AKEVTIFAAASEQFTKKNTNCSIDECLQRSDDIFRAAQAAGIPVRGYVSCVLGCPYEGKI 180
Query: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
SPAKV EV KK YSMGCYEISLGDTIGVGTPG+MKDMLSAVM EVP++ALAVHCHDTYGQ
Sbjct: 181 SPAKVVEVAKKIYSMGCYEISLGDTIGVGTPGVMKDMLSAVMHEVPVSALAVHCHDTYGQ 240
Query: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
ALANTLMALQMGVSVVDSSVAGLGGCPYA+GASGNLATEDLVYML GLGIHTGVNLQKLL
Sbjct: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYARGASGNLATEDLVYMLSGLGIHTGVNLQKLL 300
Query: 301 EAGNFICQALNRKTSSKVAQATCKL 325
EAG FICQALNRKTSSKVAQA CKL
Sbjct: 301 EAGTFICQALNRKTSSKVAQAACKL 325
>ref|XP_001166145.1| PREDICTED: similar to 3-hydroxymethyl-3-methylglutaryl-Coenzyme A
lyase (hydroxymethylglutaricaciduria) isoform 1 [Pan
troglodytes]
Length = 293
Score = 539 bits (1388), Expect = e-151, Method: Composition-based stats.
Identities = 292/325 (89%), Positives = 293/325 (90%), Gaps = 32/325 (9%)
Query: 1 MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKL+
Sbjct: 1 MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLV 60
Query: 61 DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAG 120
DMLSEAGLSVIETTSFVSPKWVPQ VAAG
Sbjct: 61 DMLSEAGLSVIETTSFVSPKWVPQ--------------------------------VAAG 88
Query: 121 AKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
AKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI
Sbjct: 89 AKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 148
Query: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ
Sbjct: 149 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 208
Query: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL
Sbjct: 209 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 268
Query: 301 EAGNFICQALNRKTSSKVAQATCKL 325
EAGNFICQALNRKTSSKVAQATCKL
Sbjct: 269 EAGNFICQALNRKTSSKVAQATCKL 293
>ref|XP_417834.1| PREDICTED: similar to Hydroxymethylglutaryl-CoA lyase (HMG-CoA
lyase) (HL) (3-hydroxy-3-methylglutarate-CoA lyase)
[Gallus gallus]
Length = 319
Score = 498 bits (1281), Expect = e-139, Method: Composition-based stats.
Identities = 251/325 (77%), Positives = 288/325 (88%), Gaps = 6/325 (1%)
Query: 1 MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
MAA+R+ LPR V SLR VST++ P+RVK+VEVGPRDGLQNEK++V TPVKI+LI
Sbjct: 1 MAAVRRLLPRWAV---SLRPVSTAA---FPQRVKVVEVGPRDGLQNEKSVVPTPVKIRLI 54
Query: 61 DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAG 120
DMLSE GL VIE TSFVSP+WVPQM DH EV++GI K PG++YPVLTPNLKGF+AAVAAG
Sbjct: 55 DMLSETGLPVIEATSFVSPRWVPQMADHAEVMQGINKLPGVSYPVLTPNLKGFQAAVAAG 114
Query: 121 AKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
AKEV IFGAASELFTKKNINCSIEES +RF ++ AA++A+I VRGYVSC LGCPYEG I
Sbjct: 115 AKEVSIFGAASELFTKKNINCSIEESLERFSEVMNAARAASIPVRGYVSCVLGCPYEGNI 174
Query: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
S AKVAEV+KK YSMGCYEISLGDTIG+GTPG MK+ML+AVM+EVP+ ALAVHCHDTYGQ
Sbjct: 175 SAAKVAEVSKKMYSMGCYEISLGDTIGIGTPGSMKEMLAAVMKEVPVGALAVHCHDTYGQ 234
Query: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
ALAN L+ALQMGVSVVD+SVAGLGGCPYAQGASGN+ATEDLVYML GLGIHTGV+LQKL+
Sbjct: 235 ALANILVALQMGVSVVDASVAGLGGCPYAQGASGNVATEDLVYMLNGLGIHTGVDLQKLM 294
Query: 301 EAGNFICQALNRKTSSKVAQATCKL 325
+ G FIC ALNR+T+SKV+QA C+L
Sbjct: 295 DTGTFICNALNRRTNSKVSQAACRL 319
>ref|XP_001363832.1| PREDICTED: similar to alpha-2-macroglobulin receptor [Monodelphis
domestica]
Length = 327
Score = 484 bits (1247), Expect = e-135, Method: Composition-based stats.
Identities = 251/313 (80%), Positives = 281/313 (89%)
Query: 9 PRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGL 68
P RL G +SLRA+S+SS+ PK+VKIVEVGPRDGLQNEK+I+ T +KIKLIDMLS AGL
Sbjct: 10 PLRLAGTSSLRAISSSSLDAFPKQVKIVEVGPRDGLQNEKHILPTQMKIKLIDMLSAAGL 69
Query: 69 SVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFG 128
VIE TSFVSPKWVPQM DH EVL+GI+KFPGI+YPVLTPNL+GF+AAVAAGAKEV IFG
Sbjct: 70 PVIEATSFVSPKWVPQMADHAEVLQGIEKFPGISYPVLTPNLRGFQAAVAAGAKEVAIFG 129
Query: 129 AASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEV 188
AASELF+KKNINCSIEES+QRF+ +L A+ ANI VRGYVSC LGCPYEGK+SPAKVAEV
Sbjct: 130 AASELFSKKNINCSIEESYQRFEEVLTEARCANIPVRGYVSCVLGCPYEGKVSPAKVAEV 189
Query: 189 TKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMA 248
KK YSMGC+EISLGDTIGVGTP MK+MLSAVM+E+P++ALAVHCHDTYGQALAN LMA
Sbjct: 190 AKKLYSMGCFEISLGDTIGVGTPLGMKNMLSAVMKEMPVSALAVHCHDTYGQALANILMA 249
Query: 249 LQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQ 308
LQMGVSVVDSSVAGLGGCPY+ GASGN+ATEDL+YML GLGI TGVNLQKL +AG FIC+
Sbjct: 250 LQMGVSVVDSSVAGLGGCPYSPGASGNVATEDLLYMLNGLGIDTGVNLQKLTDAGKFICK 309
Query: 309 ALNRKTSSKVAQA 321
ALNRK SSKVA A
Sbjct: 310 ALNRKNSSKVATA 322
>sp|P35915|HMGCL_CHICK Hydroxymethylglutaryl-CoA lyase (HMG-CoA lyase) (HL)
(3-hydroxy-3-methylglutarate-CoA lyase)
Length = 298
Score = 482 bits (1240), Expect = e-134, Method: Composition-based stats.
Identities = 236/297 (79%), Positives = 269/297 (90%)
Query: 29 LPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQMGDH 88
P+RVK+VEVGPRDGLQNEK++V TPVKI+LIDMLSE GL VIE TSFVSP+WVPQM DH
Sbjct: 2 FPQRVKVVEVGPRDGLQNEKSVVPTPVKIRLIDMLSETGLPVIEATSFVSPRWVPQMADH 61
Query: 89 TEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNINCSIEESFQ 148
EV++GI K PG++YPVLTPNLKGF+AAVAAGAKEV IFGAASELFTKKNINCSIEES +
Sbjct: 62 AEVMQGINKLPGVSYPVLTPNLKGFQAAVAAGAKEVSIFGAASELFTKKNINCSIEESLE 121
Query: 149 RFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLGDTIGV 208
RF ++ AA++A+I VRGYVSC LGCPYEG IS AKVAEV+KK YSMGCYEISLGD IG+
Sbjct: 122 RFSEVMNAARAASIPVRGYVSCVLGCPYEGNISAAKVAEVSKKMYSMGCYEISLGDRIGI 181
Query: 209 GTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGGCPY 268
GTPG MK+ML+AVM+EVP+ ALAVHCHDTYGQALAN L+ALQMGVSVVD+SVAGLGGCPY
Sbjct: 182 GTPGSMKEMLAAVMKEVPVGALAVHCHDTYGQALANILVALQMGVSVVDASVAGLGGCPY 241
Query: 269 AQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQATCKL 325
AQGASGN+ATEDLVYML GLGIHTGV+LQKL++ G FIC ALNR+T+SKV+QA C+L
Sbjct: 242 AQGASGNVATEDLVYMLNGLGIHTGVDLQKLMDTGTFICNALNRRTNSKVSQAACRL 298
>gb|AAA92728.1| hydroxymethylglutaryl-CoA lyase
Length = 292
Score = 471 bits (1213), Expect = e-131, Method: Composition-based stats.
Identities = 231/292 (79%), Positives = 264/292 (90%)
Query: 34 KIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLK 93
+ +EVGPRDGLQNEK++V TPVKI+LIDMLSE GL VIE TSFVSP+WVPQM DH EV++
Sbjct: 1 EFLEVGPRDGLQNEKSVVPTPVKIRLIDMLSETGLPVIEATSFVSPRWVPQMADHAEVMQ 60
Query: 94 GIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNINCSIEESFQRFDAI 153
GI K PG++YPVLTPNLKGF+AAVAAGAKEV IFGAASELFTKKNINCSIEES +RF +
Sbjct: 61 GINKLPGVSYPVLTPNLKGFQAAVAAGAKEVSIFGAASELFTKKNINCSIEESLERFSEV 120
Query: 154 LKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGI 213
+ AA++A+I VRGYVSC LGCPYEG IS AKVAEV+KK YSMGCYEISLGD IG+GTPG
Sbjct: 121 MNAARAASIPVRGYVSCVLGCPYEGNISAAKVAEVSKKMYSMGCYEISLGDRIGIGTPGS 180
Query: 214 MKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGGCPYAQGAS 273
MK+ML+AVM+EVP+ ALAVHCHDTYGQALAN L+ALQMGVSVVD+SVAGLGGCPYAQGAS
Sbjct: 181 MKEMLAAVMKEVPVGALAVHCHDTYGQALANILVALQMGVSVVDASVAGLGGCPYAQGAS 240
Query: 274 GNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQATCKL 325
GN+ATEDLVYML GLGIHTGV+LQKL++ G FIC ALNR+T+SKV+QA C+L
Sbjct: 241 GNVATEDLVYMLNGLGIHTGVDLQKLMDTGTFICNALNRRTNSKVSQAACRL 292
>ref|NP_957509.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase
(hydroxymethylglutaricaciduria) [Danio rerio]
gb|AAH46023.1| Zgc:56248 [Danio rerio]
Length = 340
Score = 471 bits (1212), Expect = e-131, Method: Composition-based stats.
Identities = 236/312 (75%), Positives = 275/312 (88%), Gaps = 2/312 (0%)
Query: 16 ASLRAVSTSSMGT--LPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIET 73
A +R+VS S+ + LP+RVKIVEVGPRDGLQNEK IV T VKI+LIDMLSEAGL VIE
Sbjct: 29 ALIRSVSVSAAASQALPERVKIVEVGPRDGLQNEKTIVPTEVKIRLIDMLSEAGLPVIEA 88
Query: 74 TSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASEL 133
TSFVSPKWVPQM D EV++G+ K PG+NYPVLTPNLKGF+AAV AGAKEV IFGAASEL
Sbjct: 89 TSFVSPKWVPQMADQEEVMRGLHKKPGVNYPVLTPNLKGFQAAVKAGAKEVAIFGAASEL 148
Query: 134 FTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFY 193
F+KKNINCS+EES RF+ ++ AA+ +SVRGYVSC LGCPYEGK+SP+KVAEV K+ Y
Sbjct: 149 FSKKNINCSVEESLVRFEEVMTAAKQEGVSVRGYVSCVLGCPYEGKVSPSKVAEVAKRLY 208
Query: 194 SMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGV 253
SMGCYE+SLGDTIGVGTPG M +ML+AV +E+P+ ALAVHCHDTYGQALAN L+ALQ GV
Sbjct: 209 SMGCYEVSLGDTIGVGTPGGMTEMLNAVKKELPVEALAVHCHDTYGQALANILVALQNGV 268
Query: 254 SVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRK 313
SVVDSSVAGLGGCPYAQGASGN+ATED+VYML GLGIHTGV+L +LL+AG+FIC ++NR+
Sbjct: 269 SVVDSSVAGLGGCPYAQGASGNVATEDVVYMLHGLGIHTGVDLPRLLDAGSFICHSINRR 328
Query: 314 TSSKVAQATCKL 325
T+SKVAQA+CKL
Sbjct: 329 TNSKVAQASCKL 340
>ref|NP_001085152.1| hypothetical protein LOC432233 [Xenopus laevis]
gb|AAH72247.1| MGC82338 protein [Xenopus laevis]
Length = 328
Score = 464 bits (1194), Expect = e-129, Method: Composition-based stats.
Identities = 230/311 (73%), Positives = 264/311 (84%)
Query: 15 LASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETT 74
LA LR + + + + PK VKIVEVGPRDGLQNEK +V T VKI LI+MLSEAGL IE T
Sbjct: 18 LAILRQIGSLPIQSFPKEVKIVEVGPRDGLQNEKTVVPTDVKIHLINMLSEAGLQAIEAT 77
Query: 75 SFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELF 134
SFVSPKWVPQM DH V++GI+K+P I+YPVLTPNL GF+AAV GAKEV IFGAASELF
Sbjct: 78 SFVSPKWVPQMADHKNVMQGIKKYPNISYPVLTPNLTGFQAAVECGAKEVAIFGAASELF 137
Query: 135 TKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYS 194
+KKNINCSI+ES QRF A++ A+ ANI VRGYVSC LGCPYEGK++P+KVAEV K +S
Sbjct: 138 SKKNINCSIDESLQRFKAVITEAKEANIPVRGYVSCVLGCPYEGKVAPSKVAEVAYKMFS 197
Query: 195 MGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVS 254
MGCYEISLGDTIGVGTPG M+DMLSAV+ VP ALAVHCHDTYGQALAN L+ALQMGV
Sbjct: 198 MGCYEISLGDTIGVGTPGGMRDMLSAVLDVVPAKALAVHCHDTYGQALANILVALQMGVQ 257
Query: 255 VVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKT 314
VVD+SVAGLGGCPYAQGASGN+ATED+VYML GLGI TG++L+KL EAG FIC+AL +K+
Sbjct: 258 VVDASVAGLGGCPYAQGASGNVATEDVVYMLHGLGIQTGIDLKKLTEAGAFICKALGKKS 317
Query: 315 SSKVAQATCKL 325
SKV+QA CKL
Sbjct: 318 HSKVSQAICKL 328
>emb|CAG09900.1| unnamed protein product [Tetraodon nigroviridis]
Length = 337
Score = 462 bits (1188), Expect = e-128, Method: Composition-based stats.
Identities = 231/310 (74%), Positives = 266/310 (85%), Gaps = 5/310 (1%)
Query: 16 ASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTS 75
A LRA T LP++VKIVEVGPRDGLQNEK IV + KI LID+LS +GL VIE TS
Sbjct: 33 AGLRACQT-----LPEKVKIVEVGPRDGLQNEKTIVPSETKIHLIDLLSASGLPVIEATS 87
Query: 76 FVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFT 135
FVSPKWVPQM D EV+KGI + PG++YPVLTPNLKGF+AAV AGA EV IFGAASELF+
Sbjct: 88 FVSPKWVPQMADQVEVMKGISRRPGVSYPVLTPNLKGFQAAVQAGASEVAIFGAASELFS 147
Query: 136 KKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSM 195
KKNINCS++ES QRFD ++KAA+ A + VRGYVSC LGCPYEGK+ P KVA V K+ Y+M
Sbjct: 148 KKNINCSVDESLQRFDEVMKAAKEAGVPVRGYVSCVLGCPYEGKVEPVKVAHVAKRLYAM 207
Query: 196 GCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSV 255
GCYEISLGDTIGVGTPG M+DML V +EVP++ALAVHCHDTYGQALAN L+ALQMGVSV
Sbjct: 208 GCYEISLGDTIGVGTPGSMRDMLEVVSREVPVSALAVHCHDTYGQALANILVALQMGVSV 267
Query: 256 VDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTS 315
VDSSVAGLGGCPYAQGASGN+ATED+VYML GLGI TGV+L K+++AG FIC++LNR+T+
Sbjct: 268 VDSSVAGLGGCPYAQGASGNVATEDVVYMLHGLGIQTGVDLSKVMDAGAFICRSLNRRTN 327
Query: 316 SKVAQATCKL 325
SKVAQATCKL
Sbjct: 328 SKVAQATCKL 337
>gb|AAL89669.1|AF411956_10 hydroxymethylglutaryl-CoA lyase [Takifugu rubripes]
Length = 325
Score = 453 bits (1166), Expect = e-126, Method: Composition-based stats.
Identities = 226/295 (76%), Positives = 258/295 (87%)
Query: 31 KRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQMGDHTE 90
+ VKIVEVGPRDGLQNEK IV KI LIDMLS +GL VIE TSFVSPKWVPQM D E
Sbjct: 31 QSVKIVEVGPRDGLQNEKTIVPLETKIHLIDMLSASGLPVIEATSFVSPKWVPQMADQVE 90
Query: 91 VLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNINCSIEESFQRF 150
V+KGI + PG++YPVLTPNLKGF+AAV+AGA EV IFGAASELF+KKNINCS++ES QRF
Sbjct: 91 VMKGISRKPGVSYPVLTPNLKGFQAAVSAGASEVAIFGAASELFSKKNINCSVDESLQRF 150
Query: 151 DAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLGDTIGVGT 210
D ++KAA+ A + VRGYVSC LGCPYEGK+ PAKVA V K+ YSMGCYEISLGDTIGVGT
Sbjct: 151 DEVMKAAKEAGVPVRGYVSCVLGCPYEGKVEPAKVAHVAKRLYSMGCYEISLGDTIGVGT 210
Query: 211 PGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGGCPYAQ 270
PG M +ML V +EVP++ALAVHCHDTYGQALAN L+ALQMGVSVVDSSVAGLGGCPYAQ
Sbjct: 211 PGSMCEMLKVVSREVPVSALAVHCHDTYGQALANILVALQMGVSVVDSSVAGLGGCPYAQ 270
Query: 271 GASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQATCKL 325
GASGN+ATED+VYML GLGI TGV+L K+++AG FIC++LNRK++SKVAQATCKL
Sbjct: 271 GASGNVATEDVVYMLHGLGIQTGVDLSKVMDAGAFICRSLNRKSNSKVAQATCKL 325
>ref|XP_538973.2| PREDICTED: similar to 3-hydroxymethyl-3-methylglutaryl-Coenzyme A
lyase-like 1 [Canis familiaris]
Length = 343
Score = 449 bits (1155), Expect = e-124, Method: Composition-based stats.
Identities = 215/303 (70%), Positives = 260/303 (85%)
Query: 20 AVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSP 79
A TS + LP+ VKIVEVGPRDGLQNEK IV T +KI+ I+ LS+ GLSVIE TSFVS
Sbjct: 35 AQETSQLSGLPEYVKIVEVGPRDGLQNEKVIVPTDIKIEFINQLSQTGLSVIEVTSFVSS 94
Query: 80 KWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNI 139
KWVPQM DHTEV+KGI ++PG+ YPVLTPNL+GF AVAAGA E+ +FGAASE F+K+NI
Sbjct: 95 KWVPQMADHTEVMKGIHQYPGVRYPVLTPNLQGFHRAVAAGATEISVFGAASESFSKRNI 154
Query: 140 NCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYE 199
NCSIEES ++F+ ++K+A+ NI RGYVSCALGCPYEG I+P KV EV+KK Y MGCYE
Sbjct: 155 NCSIEESMEKFEEVVKSARHMNIPARGYVSCALGCPYEGNITPQKVTEVSKKLYGMGCYE 214
Query: 200 ISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSS 259
ISLGDT GVGTPG MK ML +VM+E+P +ALAVHCHDTYGQALAN L ALQMG++VVDS+
Sbjct: 215 ISLGDTTGVGTPGSMKRMLESVMKEIPSSALAVHCHDTYGQALANILTALQMGINVVDSA 274
Query: 260 VAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVA 319
V+GLGGCPYA+GASGN+ATEDL+YML GLG++TGVNL K++EAG+FIC+A+N+ T+SKVA
Sbjct: 275 VSGLGGCPYAKGASGNVATEDLIYMLNGLGLNTGVNLYKVMEAGDFICKAVNKTTNSKVA 334
Query: 320 QAT 322
QA+
Sbjct: 335 QAS 337
>ref|XP_001499476.1| PREDICTED: similar to 3-hydroxymethyl-3-methylglutaryl-Coenzyme A
lyase-like 1 [Equus caballus]
Length = 435
Score = 449 bits (1154), Expect = e-124, Method: Composition-based stats.
Identities = 215/305 (70%), Positives = 259/305 (84%)
Query: 20 AVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSP 79
A +S LP+ VKIVEVGPRDGLQNEK IV T +KI+ I+ LS+ GLSVIE TSFVS
Sbjct: 123 AQESSQFSGLPEYVKIVEVGPRDGLQNEKVIVPTDIKIEFINQLSQTGLSVIEVTSFVSS 182
Query: 80 KWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNI 139
+WVPQM DHTEV+KGI + PG+ YPVLTPNL+GF AVAAGA E+ +FGAASE F+KKNI
Sbjct: 183 RWVPQMADHTEVMKGIHQHPGVRYPVLTPNLQGFHRAVAAGATEISVFGAASESFSKKNI 242
Query: 140 NCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYE 199
NCSIEES ++F+ ++K+A+ NI RGYVSCALGCPYEG I+ KV EV+K+ Y MGCYE
Sbjct: 243 NCSIEESMEKFEEVVKSARHMNIPARGYVSCALGCPYEGGITTQKVTEVSKRLYGMGCYE 302
Query: 200 ISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSS 259
ISLGDTIGVGTPG M+ ML +VM+E+P +ALAVHCHDTYGQALAN L ALQMG++VVDS+
Sbjct: 303 ISLGDTIGVGTPGSMRRMLESVMKEIPSSALAVHCHDTYGQALANILTALQMGINVVDSA 362
Query: 260 VAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVA 319
VAGLGGCPYA+GASGN+ATEDL+YML GLG+HTGVNL K++EAG+FIC+A+N+ T+SKVA
Sbjct: 363 VAGLGGCPYAKGASGNVATEDLIYMLHGLGLHTGVNLYKVMEAGDFICKAVNKSTNSKVA 422
Query: 320 QATCK 324
QA+ K
Sbjct: 423 QASFK 427
>ref|NP_061909.2| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-like 1 isoform a
[Homo sapiens]
sp|Q8TB92|HMGC2_HUMAN Probable 3-hydroxymethyl-3-methylglutaryl-CoA lyase 2
(3-hydroxymethyl-3-methylglutaryl-CoA lyase-like protein
1)
gb|EAX04443.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-like 1, isoform
CRA_b [Homo sapiens]
Length = 370
Score = 449 bits (1154), Expect = e-124, Method: Composition-based stats.
Identities = 216/311 (69%), Positives = 261/311 (83%)
Query: 12 LVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVI 71
L G + TS + LP+ VKIVEVGPRDGLQNEK IV T +KI+ I+ LS+ GLSVI
Sbjct: 57 LAGTVACIHWETSQLSGLPEFVKIVEVGPRDGLQNEKVIVPTDIKIEFINRLSQTGLSVI 116
Query: 72 ETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAAS 131
E TSFVS +WVPQM DHTEV+KGI ++PG+ YPVLTPNL+GF AVAAGA E+ +FGAAS
Sbjct: 117 EVTSFVSSRWVPQMADHTEVMKGIHQYPGVRYPVLTPNLQGFHHAVAAGATEISVFGAAS 176
Query: 132 ELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKK 191
E F+KKNINCSIEES +F+ ++K+A+ NI RGYVSCALGCPYEG I+P KV EV+K+
Sbjct: 177 ESFSKKNINCSIEESMGKFEEVVKSARHMNIPARGYVSCALGCPYEGSITPQKVTEVSKR 236
Query: 192 FYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQM 251
Y MGCYEISLGDTIGVGTPG MK ML +VM+E+P ALAVHCHDTYGQALAN L ALQM
Sbjct: 237 LYGMGCYEISLGDTIGVGTPGSMKRMLESVMKEIPPGALAVHCHDTYGQALANILTALQM 296
Query: 252 GVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALN 311
G++VVDS+V+GLGGCPYA+GASGN+ATEDL+YML GLG++TGVNL K++EAG+FIC+A+N
Sbjct: 297 GINVVDSAVSGLGGCPYAKGASGNVATEDLIYMLNGLGLNTGVNLYKVMEAGDFICKAVN 356
Query: 312 RKTSSKVAQAT 322
+ T+SKVAQA+
Sbjct: 357 KTTNSKVAQAS 367
>ref|XP_001105003.1| PREDICTED: similar to 3-hydroxymethyl-3-methylglutaryl-Coenzyme A
lyase-like 1 [Macaca mulatta]
Length = 444
Score = 448 bits (1153), Expect = e-124, Method: Composition-based stats.
Identities = 216/300 (72%), Positives = 261/300 (87%)
Query: 23 TSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWV 82
TS + LP+ VKIVEVGPRDGLQNEK IV T +KI+ I+ LS+ GLSVIE TSFVS +WV
Sbjct: 142 TSQLSGLPEFVKIVEVGPRDGLQNEKVIVPTDIKIEFINRLSQTGLSVIEVTSFVSSRWV 201
Query: 83 PQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNINCS 142
PQM DHTEV+KGI ++PG++YPVLTPNL+GF AVAAGA E+ +FGAASE F+KKNINCS
Sbjct: 202 PQMADHTEVMKGIHQYPGVHYPVLTPNLQGFHRAVAAGATEISVFGAASESFSKKNINCS 261
Query: 143 IEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISL 202
IEES +F+ ++K+A+ NI RGYVSCALGCPYEG I+P KV EV+K+ YSMGCYEISL
Sbjct: 262 IEESMGKFEEVVKSARHMNIPARGYVSCALGCPYEGIITPQKVTEVSKRLYSMGCYEISL 321
Query: 203 GDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAG 262
GDTIGVGTPG MK ML +VM+E+PL ALAVHCHDTYGQALAN L ALQMG++VVDS+V+G
Sbjct: 322 GDTIGVGTPGSMKRMLESVMKEIPLGALAVHCHDTYGQALANILTALQMGINVVDSAVSG 381
Query: 263 LGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQAT 322
LGGCPYA+GASGN+ATEDL+YML GLG++TGVNL K++EAG+FIC+A+N+ T+SKVAQA+
Sbjct: 382 LGGCPYAKGASGNVATEDLIYMLNGLGLNTGVNLYKVMEAGDFICKAVNKTTNSKVAQAS 441
>ref|XP_419903.1| PREDICTED: similar to 3-hydroxymethyl-3-methylglutaryl-Coenzyme A
lyase-like 1 [Gallus gallus]
Length = 420
Score = 447 bits (1151), Expect = e-124, Method: Composition-based stats.
Identities = 220/299 (73%), Positives = 259/299 (86%)
Query: 24 SSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVP 83
S LP+ VKIVEVGPRDGLQNEK IV T KI+LI+ LS+ GL IE TSFVS KWVP
Sbjct: 115 SQASGLPEYVKIVEVGPRDGLQNEKVIVPTDTKIELINRLSKTGLPAIEVTSFVSSKWVP 174
Query: 84 QMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNINCSI 143
QM DH EV++GI++ PG+ YPVLTPNLKGF +A+AAGA EV +FGAASE F+K NINCSI
Sbjct: 175 QMADHKEVMRGIERHPGVQYPVLTPNLKGFHSAIAAGATEVSVFGAASESFSKMNINCSI 234
Query: 144 EESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLG 203
EES ++F+ + K+A++ NI VRGYVSCALGCPYEG I+PAKVAEV+K+ YSMGCYEISLG
Sbjct: 235 EESIEKFEEVAKSARNMNIPVRGYVSCALGCPYEGDITPAKVAEVSKRLYSMGCYEISLG 294
Query: 204 DTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGL 263
DTIGVGTPG MK ML AVM+E+PL+ALAVHCHDTYGQALAN L A+QMGV+VVDSSVAGL
Sbjct: 295 DTIGVGTPGSMKRMLEAVMKEIPLSALAVHCHDTYGQALANILTAIQMGVAVVDSSVAGL 354
Query: 264 GGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQAT 322
GGCPYA+GA+GN+ATED++YML GLGI+TGVNL ++EAGNFIC ALN+KT+SKVAQA+
Sbjct: 355 GGCPYAKGATGNVATEDVIYMLNGLGINTGVNLYTVMEAGNFICTALNKKTNSKVAQAS 413
>ref|NP_001035865.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-like 1 isoform b
[Homo sapiens]
gb|AAH24194.2| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-like 1 [Homo
sapiens]
gb|EAX04444.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-like 1, isoform
CRA_c [Homo sapiens]
Length = 340
Score = 447 bits (1149), Expect = e-124, Method: Composition-based stats.
Identities = 215/303 (70%), Positives = 259/303 (85%)
Query: 20 AVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSP 79
A TS + LP+ VKIVEVGPRDGLQNEK IV T +KI+ I+ LS+ GLSVIE TSFVS
Sbjct: 35 AQETSQLSGLPEFVKIVEVGPRDGLQNEKVIVPTDIKIEFINRLSQTGLSVIEVTSFVSS 94
Query: 80 KWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNI 139
+WVPQM DHTEV+KGI ++PG+ YPVLTPNL+GF AVAAGA E+ +FGAASE F+KKNI
Sbjct: 95 RWVPQMADHTEVMKGIHQYPGVRYPVLTPNLQGFHHAVAAGATEISVFGAASESFSKKNI 154
Query: 140 NCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYE 199
NCSIEES +F+ ++K+A+ NI RGYVSCALGCPYEG I+P KV EV+K+ Y MGCYE
Sbjct: 155 NCSIEESMGKFEEVVKSARHMNIPARGYVSCALGCPYEGSITPQKVTEVSKRLYGMGCYE 214
Query: 200 ISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSS 259
ISLGDTIGVGTPG MK ML +VM+E+P ALAVHCHDTYGQALAN L ALQMG++VVDS+
Sbjct: 215 ISLGDTIGVGTPGSMKRMLESVMKEIPPGALAVHCHDTYGQALANILTALQMGINVVDSA 274
Query: 260 VAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVA 319
V+GLGGCPYA+GASGN+ATEDL+YML GLG++TGVNL K++EAG+FIC+A+N+ T+SKVA
Sbjct: 275 VSGLGGCPYAKGASGNVATEDLIYMLNGLGLNTGVNLYKVMEAGDFICKAVNKTTNSKVA 334
Query: 320 QAT 322
QA+
Sbjct: 335 QAS 337
>ref|XP_001371535.1| PREDICTED: similar to 3-hydroxymethyl-3-methylglutaryl-Coenzyme A
lyase-like 1 [Monodelphis domestica]
Length = 338
Score = 440 bits (1132), Expect = e-122, Method: Composition-based stats.
Identities = 214/303 (70%), Positives = 262/303 (86%), Gaps = 2/303 (0%)
Query: 20 AVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSP 79
A + + P+ VKIVEVGPRDGLQNEK IV T +KI+ I+ LS+ GLSVIE TSFVS
Sbjct: 35 AQEVTQLSGFPEYVKIVEVGPRDGLQNEKVIVPTDIKIEFINQLSKTGLSVIEVTSFVSS 94
Query: 80 KWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNI 139
KWVPQM D TEV+KGI ++PG+ YPVLT L+GF A+AAGA EV +FGAASE F+KKNI
Sbjct: 95 KWVPQMADQTEVMKGIYQYPGVRYPVLT--LQGFHHAIAAGATEVSVFGAASESFSKKNI 152
Query: 140 NCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYE 199
NCSIEES +RF+A++K+A+ N+ VRGYVSCALGCPYEG+I+P KVAEV+K+ YSMGCYE
Sbjct: 153 NCSIEESMERFEAVVKSARHMNVPVRGYVSCALGCPYEGQIAPEKVAEVSKQLYSMGCYE 212
Query: 200 ISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSS 259
ISLGDTIGVGTPG MK ML +VM+E+P++ALAVHCHDTYGQALAN L ALQMG++VVDS+
Sbjct: 213 ISLGDTIGVGTPGSMKRMLESVMKEIPISALAVHCHDTYGQALANILTALQMGINVVDSA 272
Query: 260 VAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVA 319
V+GLGGCPYA+GASGN+ATEDL+YML G+G++TGVNL K++EAGNFIC+A+N+ T+SKVA
Sbjct: 273 VSGLGGCPYAKGASGNVATEDLIYMLNGIGLNTGVNLYKVMEAGNFICRAINKTTNSKVA 332
Query: 320 QAT 322
QA+
Sbjct: 333 QAS 335
>ref|NP_776092.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-like 1 [Mus
musculus]
sp|Q8JZS7|HMGC2_MOUSE Probable 3-hydroxymethyl-3-methylglutaryl-CoA lyase 2
(3-hydroxymethyl-3-methylglutaryl-CoA lyase-like protein
1)
gb|AAH37381.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-like 1 [Mus
musculus]
dbj|BAE24772.1| unnamed protein product [Mus musculus]
gb|EDL26339.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-like 1, isoform
CRA_c [Mus musculus]
Length = 343
Score = 439 bits (1129), Expect = e-121, Method: Composition-based stats.
Identities = 211/303 (69%), Positives = 258/303 (85%)
Query: 20 AVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSP 79
A S + LP+ VKIVEVGPRDGLQNEK IV T +KI+LI+ LS+ GLSVIE TSFVS
Sbjct: 35 AQEASQLPGLPEYVKIVEVGPRDGLQNEKVIVPTDIKIELINQLSQTGLSVIEVTSFVSS 94
Query: 80 KWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNI 139
+WVPQM DH EV++GI+++PG+ YPVLTPNL+GF+ AVAAGA E+ +FGAASE F+KKNI
Sbjct: 95 RWVPQMADHAEVMRGIRQYPGVRYPVLTPNLQGFQHAVAAGATEIAVFGAASESFSKKNI 154
Query: 140 NCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYE 199
NCSIEES RF ++ +A+ +I VRGYVSCALGCPYEG I+P KV EV+K+ Y MGCYE
Sbjct: 155 NCSIEESMGRFQEVISSARHMDIPVRGYVSCALGCPYEGSITPQKVTEVSKRLYGMGCYE 214
Query: 200 ISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSS 259
ISLGDTIGVGTPG MK ML +VM+E+P ALAVHCHDTYGQALAN L ALQMG++VVDS+
Sbjct: 215 ISLGDTIGVGTPGSMKMMLESVMKEIPPGALAVHCHDTYGQALANILTALQMGINVVDSA 274
Query: 260 VAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVA 319
V+GLGGCPYA+GASGN+ATEDL+YML G+G++TGV+L K++EAG FIC+A+N+ T+SKVA
Sbjct: 275 VSGLGGCPYAKGASGNVATEDLIYMLNGMGLNTGVDLYKVMEAGEFICKAVNKTTNSKVA 334
Query: 320 QAT 322
QA+
Sbjct: 335 QAS 337
>ref|XP_615612.3| PREDICTED: similar to 3-hydroxymethyl-3-methylglutaryl-Coenzyme A
lyase-like 1 isoform 2 [Bos taurus]
Length = 370
Score = 437 bits (1125), Expect = e-121, Method: Composition-based stats.
Identities = 206/300 (68%), Positives = 255/300 (85%)
Query: 23 TSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWV 82
++ + P+ VKIVEVGPRDGLQNEK IV T +KI+ I+ LS+ GLSVIE TSFVS +W+
Sbjct: 68 SAQLSGFPEYVKIVEVGPRDGLQNEKVIVPTDIKIEFINQLSQTGLSVIEVTSFVSSRWI 127
Query: 83 PQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNINCS 142
PQM DHTEV+KGI ++PGI YPVLTPNL+GF AVAAGA EV +FGAASE F+KKNINCS
Sbjct: 128 PQMADHTEVMKGIHQYPGIRYPVLTPNLQGFHRAVAAGATEVSVFGAASESFSKKNINCS 187
Query: 143 IEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISL 202
IEES ++F+ ++K+A+ NI RGYVSCALGCPYEG I+ KV EV+K+ Y MGCYEISL
Sbjct: 188 IEESMKKFEEVVKSARHMNIPARGYVSCALGCPYEGNITLQKVTEVSKRLYGMGCYEISL 247
Query: 203 GDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAG 262
GDTIGVGTPG MK ML +VM+E+P ALAVHCHDTYGQA + L+ +QMG++VVDS+V+G
Sbjct: 248 GDTIGVGTPGSMKKMLESVMKEIPPRALAVHCHDTYGQASSGILLKIQMGINVVDSAVSG 307
Query: 263 LGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQAT 322
LGGCPYA+GASGN+ATEDL+YML GLG++TGVNL K++EAG+FIC+A+N+ T+SKVAQA+
Sbjct: 308 LGGCPYAKGASGNVATEDLIYMLNGLGVNTGVNLYKVMEAGDFICKAVNKTTNSKVAQAS 367
>gb|EDL77774.1| similar to 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-like 1
(predicted), isoform CRA_a [Rattus norvegicus]
Length = 343
Score = 437 bits (1124), Expect = e-121, Method: Composition-based stats.
Identities = 210/305 (68%), Positives = 256/305 (83%)
Query: 20 AVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSP 79
A S + LP+ VKIVEVGPRDGLQNEK IV T +KI+ I+ LS+ GLSVIE TSFVS
Sbjct: 35 AQEASQLSGLPEYVKIVEVGPRDGLQNEKVIVPTDIKIEFINQLSQTGLSVIEVTSFVSS 94
Query: 80 KWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNI 139
+WVPQM DH EV+ GI ++PG+ YPVL PNL+G + AVAAGA E+ +FGAASE F+KKNI
Sbjct: 95 RWVPQMADHAEVMGGIHQYPGVRYPVLVPNLQGLQHAVAAGATEIAVFGAASESFSKKNI 154
Query: 140 NCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYE 199
NCSIEES RF+ ++ +A+ NI VRGYVSCALGCPYEG I P KV EV+K+ YSMGCYE
Sbjct: 155 NCSIEESMGRFEQVISSARHMNIPVRGYVSCALGCPYEGSIMPQKVTEVSKRLYSMGCYE 214
Query: 200 ISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSS 259
ISLGDT+GVGTPG MK ML +VM+E+P ALAVHCHDTYGQALAN L ALQMG++VVDS+
Sbjct: 215 ISLGDTVGVGTPGSMKTMLESVMKEIPPGALAVHCHDTYGQALANILTALQMGINVVDSA 274
Query: 260 VAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVA 319
V+GLGGCPYA+GASGN+ATEDL+YML G+G++TGV+L K++EAG+FIC+A+N+ T+SKVA
Sbjct: 275 VSGLGGCPYAKGASGNVATEDLIYMLNGMGLNTGVDLHKVMEAGDFICKAVNKTTNSKVA 334
Query: 320 QATCK 324
QA+ K
Sbjct: 335 QASFK 339
>ref|NP_001103870.1| hypothetical protein LOC571388 [Danio rerio]
sp|A8WG57|HMGC2_DANRE Probable 3-hydroxymethyl-3-methylglutaryl-CoA lyase 2
(3-hydroxymethyl-3-methylglutaryl-CoA lyase-like protein
1)
gb|AAI54588.1| LOC571388 protein [Danio rerio]
Length = 335
Score = 436 bits (1120), Expect = e-120, Method: Composition-based stats.
Identities = 211/299 (70%), Positives = 254/299 (84%)
Query: 24 SSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVP 83
S + LP VKIVEVGPRDGLQNEK IV T VKI+LID+LS+ GL VIE TSFVS KWV
Sbjct: 34 SELPKLPVYVKIVEVGPRDGLQNEKEIVPTEVKIQLIDLLSQTGLPVIEATSFVSSKWVA 93
Query: 84 QMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNINCSI 143
QM DHT VLKGI++ P + YPVLTPN++GF+AAVAAGA EV +FG+ASE F++KNINCSI
Sbjct: 94 QMADHTAVLKGIKRSPDVRYPVLTPNIQGFQAAVAAGANEVAVFGSASETFSRKNINCSI 153
Query: 144 EESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLG 203
EES QRF+ ++ AA+ I VRGYVSCALGCPYEG++ P++V +V K+ + +GCYE+SLG
Sbjct: 154 EESLQRFEQVVSAAKQEGIPVRGYVSCALGCPYEGQVKPSQVTKVAKRLFELGCYEVSLG 213
Query: 204 DTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGL 263
DTIGVGT G M +MLS V+ EVP ALAVHCHDTYGQAL N L+ALQMGVSVVD+SVAGL
Sbjct: 214 DTIGVGTAGSMAEMLSDVLTEVPAGALAVHCHDTYGQALPNILIALQMGVSVVDASVAGL 273
Query: 264 GGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQAT 322
GGCP+A+GASGN++TEDL+YML GLGI TGV+L K++EAG+FIC+ALNRKT+SKV+QAT
Sbjct: 274 GGCPFAKGASGNVSTEDLLYMLHGLGIETGVDLLKVMEAGDFICKALNRKTNSKVSQAT 332
>ref|XP_001252308.1| PREDICTED: similar to 3-hydroxymethyl-3-methylglutaryl-Coenzyme A
lyase-like 1 isoform 1 [Bos taurus]
Length = 340
Score = 435 bits (1118), Expect = e-120, Method: Composition-based stats.
Identities = 207/303 (68%), Positives = 256/303 (84%)
Query: 20 AVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSP 79
A ++ + P+ VKIVEVGPRDGLQNEK IV T +KI+ I+ LS+ GLSVIE TSFVS
Sbjct: 35 AQESAQLSGFPEYVKIVEVGPRDGLQNEKVIVPTDIKIEFINQLSQTGLSVIEVTSFVSS 94
Query: 80 KWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNI 139
+W+PQM DHTEV+KGI ++PGI YPVLTPNL+GF AVAAGA EV +FGAASE F+KKNI
Sbjct: 95 RWIPQMADHTEVMKGIHQYPGIRYPVLTPNLQGFHRAVAAGATEVSVFGAASESFSKKNI 154
Query: 140 NCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYE 199
NCSIEES ++F+ ++K+A+ NI RGYVSCALGCPYEG I+ KV EV+K+ Y MGCYE
Sbjct: 155 NCSIEESMKKFEEVVKSARHMNIPARGYVSCALGCPYEGNITLQKVTEVSKRLYGMGCYE 214
Query: 200 ISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSS 259
ISLGDTIGVGTPG MK ML +VM+E+P ALAVHCHDTYGQA + L+ +QMG++VVDS+
Sbjct: 215 ISLGDTIGVGTPGSMKKMLESVMKEIPPRALAVHCHDTYGQASSGILLKIQMGINVVDSA 274
Query: 260 VAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVA 319
V+GLGGCPYA+GASGN+ATEDL+YML GLG++TGVNL K++EAG+FIC+A+N+ T+SKVA
Sbjct: 275 VSGLGGCPYAKGASGNVATEDLIYMLNGLGVNTGVNLYKVMEAGDFICKAVNKTTNSKVA 334
Query: 320 QAT 322
QA+
Sbjct: 335 QAS 337
>ref|XP_345954.2| PREDICTED: similar to 3-hydroxymethyl-3-methylglutaryl-Coenzyme A
lyase-like 1 [Rattus norvegicus]
ref|XP_001058331.1| PREDICTED: similar to 3-hydroxymethyl-3-methylglutaryl-Coenzyme A
lyase-like 1 [Rattus norvegicus]
Length = 433
Score = 432 bits (1110), Expect = e-119, Method: Composition-based stats.
Identities = 210/305 (68%), Positives = 256/305 (83%)
Query: 20 AVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSP 79
A S + LP+ VKIVEVGPRDGLQNEK IV T +KI+ I+ LS+ GLSVIE TSFVS
Sbjct: 125 AQEASQLSGLPEYVKIVEVGPRDGLQNEKVIVPTDIKIEFINQLSQTGLSVIEVTSFVSS 184
Query: 80 KWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNI 139
+WVPQM DH EV+ GI ++PG+ YPVL PNL+G + AVAAGA E+ +FGAASE F+KKNI
Sbjct: 185 RWVPQMADHAEVMGGIHQYPGVRYPVLVPNLQGLQHAVAAGATEIAVFGAASESFSKKNI 244
Query: 140 NCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYE 199
NCSIEES RF+ ++ +A+ NI VRGYVSCALGCPYEG I P KV EV+K+ YSMGCYE
Sbjct: 245 NCSIEESMGRFEQVISSARHMNIPVRGYVSCALGCPYEGSIMPQKVTEVSKRLYSMGCYE 304
Query: 200 ISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSS 259
ISLGDT+GVGTPG MK ML +VM+E+P ALAVHCHDTYGQALAN L ALQMG++VVDS+
Sbjct: 305 ISLGDTVGVGTPGSMKTMLESVMKEIPPGALAVHCHDTYGQALANILTALQMGINVVDSA 364
Query: 260 VAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVA 319
V+GLGGCPYA+GASGN+ATEDL+YML G+G++TGV+L K++EAG+FIC+A+N+ T+SKVA
Sbjct: 365 VSGLGGCPYAKGASGNVATEDLIYMLNGMGLNTGVDLHKVMEAGDFICKAVNKTTNSKVA 424
Query: 320 QATCK 324
QA+ K
Sbjct: 425 QASFK 429
>ref|XP_001196745.1| PREDICTED: similar to MGC82338 protein [Strongylocentrotus
purpuratus]
ref|XP_001177727.1| PREDICTED: similar to MGC82338 protein [Strongylocentrotus
purpuratus]
Length = 313
Score = 412 bits (1058), Expect = e-113, Method: Composition-based stats.
Identities = 199/297 (67%), Positives = 245/297 (82%)
Query: 29 LPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQMGDH 88
+P+ VKIVEVGPRDGLQNEK +V T KI+LI+ LS+ GL VIE TSFVSPKW+PQMGDH
Sbjct: 17 IPRSVKIVEVGPRDGLQNEKAMVPTETKIELINRLSDTGLKVIEATSFVSPKWIPQMGDH 76
Query: 89 TEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNINCSIEESFQ 148
T+V+ GI + G++YPVLTPNL+GF++A+ AGA+EV IFGAASE F+KKNINCSI+ES +
Sbjct: 77 TDVMNGITRRGGVSYPVLTPNLQGFKSALEAGAEEVAIFGAASETFSKKNINCSIDESVE 136
Query: 149 RFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLGDTIGV 208
RF ++L+AA+ AN+ VRGYVSC LGCPYEG + P VA+V K + MGCYEISLGDTIGV
Sbjct: 137 RFSSVLEAAREANVKVRGYVSCVLGCPYEGAVQPEAVAKVANKMFDMGCYEISLGDTIGV 196
Query: 209 GTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGGCPY 268
GTPG M+ +L V++ +P +AVHCHDTYGQALAN L ALQMGV+VVDSSVAGLGGCPY
Sbjct: 197 GTPGQMQVLLETVLETIPAKHIAVHCHDTYGQALANILAALQMGVTVVDSSVAGLGGCPY 256
Query: 269 AQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQATCKL 325
A+GASGN+ATED+VYML GLGI TG++L+K++ G FI + L R+ +SKV A KL
Sbjct: 257 AKGASGNVATEDVVYMLNGLGIETGIDLEKIVSVGQFISRELGRQNTSKVGNAMSKL 313
>ref|XP_001638492.1| predicted protein [Nematostella vectensis]
gb|EDO46429.1| predicted protein [Nematostella vectensis]
Length = 301
Score = 398 bits (1023), Expect = e-109, Method: Composition-based stats.
Identities = 195/292 (66%), Positives = 240/292 (82%), Gaps = 2/292 (0%)
Query: 32 RVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQ--MGDHT 89
+VKIVEVGPRDGLQNEK I+ T KIKLI+ LSE GL V+E TSFVSPKWVPQ M DH
Sbjct: 1 QVKIVEVGPRDGLQNEKTIIPTETKIKLINKLSETGLPVVEATSFVSPKWVPQAGMADHV 60
Query: 90 EVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNINCSIEESFQR 149
E++KGI + PG++YPVLTPNLKGFE+A+AAGAKEV IFGAASE F++KNINCSI+ES R
Sbjct: 61 EIMKGIDRKPGVSYPVLTPNLKGFESALAAGAKEVAIFGAASESFSRKNINCSIKESLAR 120
Query: 150 FDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLGDTIGVG 209
F+A+ +AA+ ++ VRGYVSC +GCPYEG+I+P VAEV + MGCYEISLGDTIGVG
Sbjct: 121 FEAVCQAAKDNDVKVRGYVSCVVGCPYEGEINPKAVAEVAYIMHEMGCYEISLGDTIGVG 180
Query: 210 TPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGGCPYA 269
TPG ++ ML V+ +P +ALA+HCHDTYGQALAN L++LQ+G+ +D+SV+GLGGCPYA
Sbjct: 181 TPGSIRLMLEEVVSRLPTSALAIHCHDTYGQALANILVSLQVGIRTIDASVSGLGGCPYA 240
Query: 270 QGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQA 321
GASGN++TED+VYML GLG+ TGV+L KL++ G FI AL R + SKV QA
Sbjct: 241 AGASGNVSTEDVVYMLNGLGLRTGVDLHKLIKVGEFISSALGRPSGSKVTQA 292
>dbj|BAE71196.1| putative hydroxymethylglutaryl-CoA lyase [Trifolium pratense]
Length = 433
Score = 393 bits (1009), Expect = e-107, Method: Composition-based stats.
Identities = 195/300 (65%), Positives = 237/300 (79%)
Query: 26 MGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQM 85
M +P VKIVEVGPRDGLQNEKN+VST VKI+LI L+ GLSVIE TSFVSPKWVPQ+
Sbjct: 127 MKGMPGFVKIVEVGPRDGLQNEKNMVSTDVKIELIHRLASTGLSVIEATSFVSPKWVPQL 186
Query: 86 GDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNINCSIEE 145
D +V+K + GI PVLTPNLKGFEAA+AAGA+EV +F +ASE F+K NINCSIEE
Sbjct: 187 ADAKDVMKAVHNLGGIRLPVLTPNLKGFEAAIAAGAREVAVFASASESFSKSNINCSIEE 246
Query: 146 SFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLGDT 205
S R+ A+ AA++ +I VRGYVSC +GCP EG +SP+KVA V K+ Y MGC+EISLGDT
Sbjct: 247 SLARYRAVTSAAKALSIPVRGYVSCVVGCPVEGSVSPSKVAYVAKELYDMGCFEISLGDT 306
Query: 206 IGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGG 265
IGVGTPG + ML AVM VP LAVH HDTYGQ+L+N L++LQMG+S VDSSVAGLGG
Sbjct: 307 IGVGTPGTVVPMLLAVMAVVPTEKLAVHFHDTYGQSLSNILVSLQMGISAVDSSVAGLGG 366
Query: 266 CPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQATCKL 325
CPYA+GASGN+ATED+VYML GLG+ T V+++KL+ AG+FI + L R + SK A A ++
Sbjct: 367 CPYAKGASGNVATEDVVYMLNGLGVKTNVDIEKLMSAGDFIGKHLGRPSGSKTAIALSRV 426
>gb|EAZ11369.1| hypothetical protein OsJ_001194 [Oryza sativa (japonica
cultivar-group)]
Length = 1059
Score = 393 bits (1009), Expect = e-107, Method: Composition-based stats.
Identities = 192/293 (65%), Positives = 231/293 (78%)
Query: 29 LPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQMGDH 88
LP+ VKIVEVGPRDGLQNEKNIV T VKI+LI L+ +GLSV+E TSFVSPKWVPQ+ D
Sbjct: 754 LPRSVKIVEVGPRDGLQNEKNIVPTHVKIELIQRLATSGLSVVEATSFVSPKWVPQLADA 813
Query: 89 TEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNINCSIEESFQ 148
+V+ ++ G++ PVLTPNLKGFEAAVAAGAKEV +F +ASE F+K NINC+I+ES
Sbjct: 814 KDVMDVVRNIEGVSLPVLTPNLKGFEAAVAAGAKEVAVFASASEAFSKSNINCTIKESLA 873
Query: 149 RFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLGDTIGV 208
R+ + AA+ I +RGYVSC +GCP EG + P+ VA V K+ Y MGCYE+SLGDTIGV
Sbjct: 874 RYKDVALAAKELKIPMRGYVSCVVGCPVEGYVPPSNVAHVAKELYDMGCYEVSLGDTIGV 933
Query: 209 GTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGGCPY 268
GTPG + ML AVM VP LAVH HDTYGQ+L+N L++LQMGVSVVDSSVAGLGGCPY
Sbjct: 934 GTPGTVVPMLEAVMFFVPKEKLAVHFHDTYGQSLSNILISLQMGVSVVDSSVAGLGGCPY 993
Query: 269 AQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQA 321
A+GASGN+ATED+VYML GLGI T V+L K++ AG FIC L R++ SK A A
Sbjct: 994 AKGASGNVATEDVVYMLNGLGISTNVDLGKVMAAGEFICNHLGRQSGSKAAIA 1046
>gb|EAY73450.1| hypothetical protein OsI_001297 [Oryza sativa (indica
cultivar-group)]
Length = 994
Score = 392 bits (1008), Expect = e-107, Method: Composition-based stats.
Identities = 192/293 (65%), Positives = 231/293 (78%)
Query: 29 LPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQMGDH 88
LP+ VKIVEVGPRDGLQNEKNIV T VKI+LI L+ +GLSV+E TSFVSPKWVPQ+ D
Sbjct: 689 LPRSVKIVEVGPRDGLQNEKNIVPTHVKIELIQRLATSGLSVVEATSFVSPKWVPQLADA 748
Query: 89 TEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNINCSIEESFQ 148
+V+ ++ G++ PVLTPNLKGFEAAVAAGAKEV +F +ASE F+K NINC+I+ES
Sbjct: 749 KDVMDVVRNIEGVSLPVLTPNLKGFEAAVAAGAKEVAVFASASEAFSKSNINCTIKESLA 808
Query: 149 RFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLGDTIGV 208
R+ + AA+ I +RGYVSC +GCP EG + P+ VA V K+ Y MGCYE+SLGDTIGV
Sbjct: 809 RYKDVALAAKELKIPMRGYVSCVVGCPVEGYVPPSNVAHVAKELYDMGCYEVSLGDTIGV 868
Query: 209 GTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGGCPY 268
GTPG + ML AVM VP LAVH HDTYGQ+L+N L++LQMGVSVVDSSVAGLGGCPY
Sbjct: 869 GTPGTVVPMLEAVMFFVPKEKLAVHFHDTYGQSLSNILISLQMGVSVVDSSVAGLGGCPY 928
Query: 269 AQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQA 321
A+GASGN+ATED+VYML GLGI T V+L K++ AG FIC L R++ SK A A
Sbjct: 929 AKGASGNVATEDVVYMLNGLGISTNVDLGKVMAAGEFICNHLGRQSGSKAAIA 981
>ref|XP_314824.4| AGAP008717-PA [Anopheles gambiae str. PEST]
gb|EAA10214.4| AGAP008717-PA [Anopheles gambiae str. PEST]
Length = 303
Score = 392 bits (1007), Expect = e-107, Method: Composition-based stats.
Identities = 192/295 (65%), Positives = 233/295 (78%)
Query: 30 PKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQMGDHT 89
P V+IVEVGPRDGLQNE I+ VKI+LI+ LSE GL IE TSFVS KWVPQMGD+
Sbjct: 3 PVAVRIVEVGPRDGLQNEPTILPAAVKIELINQLSETGLRTIEATSFVSAKWVPQMGDNA 62
Query: 90 EVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNINCSIEESFQR 149
EVLKGI K PGI+YPVLTPNLKGF+AA+AAGA+EV +FGAASE F++KN+NCS++ES R
Sbjct: 63 EVLKGINKLPGISYPVLTPNLKGFQAAMAAGAEEVAVFGAASESFSRKNVNCSVDESIAR 122
Query: 150 FDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLGDTIGVG 209
F +++AA+ AN+ VRGYVS +GCPYEGKI P+ V V +K MGCYE+SLGDTIGVG
Sbjct: 123 FQDVMEAAKKANVKVRGYVSTVVGCPYEGKIKPSAVVRVVEKLIEMGCYEVSLGDTIGVG 182
Query: 210 TPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGGCPYA 269
TPG +ML V + P+ LAVHCHDTYGQAL N L +L G++VVD+SV+GLGGCPYA
Sbjct: 183 TPGSFTEMLREVTKIAPVNMLAVHCHDTYGQALPNILTSLDFGIAVVDASVSGLGGCPYA 242
Query: 270 QGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQATCK 324
+GASGN ATED+VYML GLGI TG++L KL+ G FIC+ L R++ SKV +A K
Sbjct: 243 RGASGNAATEDVVYMLHGLGIETGIDLPKLVNVGKFICEKLQRQSESKVNRAMRK 297
>ref|XP_001355781.1| GA10298-PA [Drosophila pseudoobscura]
gb|EAL32840.1| GA10298-PA [Drosophila pseudoobscura]
Length = 327
Score = 392 bits (1006), Expect = e-107, Method: Composition-based stats.
Identities = 195/318 (61%), Positives = 245/318 (77%), Gaps = 5/318 (1%)
Query: 8 LPRRLV----GLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDML 63
+PR L+ LAS A T+ + + +V+IVEVGPRDGLQNE I+ KI+LID L
Sbjct: 3 IPRILLPAYRSLASFTAKRTA-VTSQSNQVRIVEVGPRDGLQNEAKILPAATKIELIDRL 61
Query: 64 SEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKE 123
SE GL+ IE TSFVS KWVPQMGD++EV +GI+K PGINYPVLTPNLKGFE+A+AAGA+E
Sbjct: 62 SETGLTTIEATSFVSSKWVPQMGDNSEVFRGIRKVPGINYPVLTPNLKGFESALAAGAEE 121
Query: 124 VVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPA 183
V +FGAAS+ F+ KN+NC+ E+ +RF +LKA+Q + VRGYVS +GCPYEG ++P+
Sbjct: 122 VAVFGAASDAFSLKNVNCTAAEAIERFKPVLKASQKHGVRVRGYVSTIVGCPYEGAVAPS 181
Query: 184 KVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALA 243
V V + Y MGCYEISLGDTIGVGTPG M+ ML V + VP LAVHCHDTYGQAL+
Sbjct: 182 AVVRVVEALYEMGCYEISLGDTIGVGTPGSMRRMLDEVARAVPAENLAVHCHDTYGQALS 241
Query: 244 NTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAG 303
N L++L+ G+ VVDSSV+GLGGCPYA+GASGN ATED+VYML G+G++TGVNL KL++ G
Sbjct: 242 NILVSLEYGIRVVDSSVSGLGGCPYARGASGNAATEDVVYMLHGMGLNTGVNLDKLIQVG 301
Query: 304 NFICQALNRKTSSKVAQA 321
+IC L R + SKV +A
Sbjct: 302 RYICTELGRPSESKVNRA 319
>gb|ABA95738.2| Hydroxymethylglutaryl-CoA lyase, mitochondrial precursor, putative,
expressed [Oryza sativa (japonica cultivar-group)]
gb|EAY82185.1| hypothetical protein OsI_036144 [Oryza sativa (indica
cultivar-group)]
gb|EAZ17365.1| hypothetical protein OsJ_031574 [Oryza sativa (japonica
cultivar-group)]
Length = 387
Score = 391 bits (1005), Expect = e-107, Method: Composition-based stats.
Identities = 189/308 (61%), Positives = 240/308 (77%)
Query: 18 LRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFV 77
RA+ + LP+ VKIVEVGPRDGLQNEKN V T VKI+LI L +GLSV+E TSFV
Sbjct: 78 FRALPRKVLWDLPRFVKIVEVGPRDGLQNEKNTVPTSVKIELIHKLVASGLSVVEATSFV 137
Query: 78 SPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKK 137
SPKWVPQ+ D +V++GI+ P + +PVLTPNL+GFEAAVAAGAKEV +F +ASE F+K
Sbjct: 138 SPKWVPQLADAKDVVEGIKHVPDVRFPVLTPNLRGFEAAVAAGAKEVAVFASASESFSKS 197
Query: 138 NINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGC 197
N+NC+I+ES R+ ++ +A+ I +RGYVSC +GCP EG I P+KVA V K+ Y MGC
Sbjct: 198 NLNCTIKESLVRYHDVVTSAKKHGIRIRGYVSCVVGCPVEGTIHPSKVAYVAKELYDMGC 257
Query: 198 YEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVD 257
EISLGDTIGVGTPG + ML AVM VP+ +AVH HDTYGQALAN L++LQ+G+++VD
Sbjct: 258 SEISLGDTIGVGTPGSVLAMLEAVMSFVPVDKIAVHFHDTYGQALANILVSLQLGINIVD 317
Query: 258 SSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSK 317
SSV+GLGGCPYA+GA+GN+ATED+VYML GLGI T V+L KL++AG++I + L R++ SK
Sbjct: 318 SSVSGLGGCPYAKGATGNVATEDVVYMLHGLGIETNVDLNKLMDAGDYISKHLGRQSGSK 377
Query: 318 VAQATCKL 325
A KL
Sbjct: 378 TTTALRKL 385
Searching..................................................done
Results from round 2
Score E
Sequences producing significant alignments: (bits) Value
Sequences used in model and found again:
ref|NP_000182.2| 3-hydroxymethyl-3-methylglutaryl-Coenzyme ... 536 e-150
gb|AAA92733.1| hydroxymethylglutaryl-CoA lyase [Homo sapiens] 534 e-150
ref|XP_001166273.1| PREDICTED: 3-hydroxymethyl-3-methylglut... 534 e-150
sp|Q8HXZ6|HMGCL_MACFA Hydroxymethylglutaryl-CoA lyase, mito... 533 e-149
sp|Q5R9E1|HMGCL_PONPY Hydroxymethylglutaryl-CoA lyase, mito... 532 e-149
ref|NP_077362.1| 3-hydroxy-3-methylglutaryl-Coenzyme A lyas... 528 e-148
ref|NP_032280.2| 3-hydroxy-3-methylglutaryl-Coenzyme A lyas... 528 e-148
dbj|BAE88248.1| unnamed protein product [Macaca fascicularis] 528 e-148
dbj|BAE26056.1| unnamed protein product [Mus musculus] 527 e-148
gb|AAB03107.1| 3-hydroxy-3-methylglutaryl-CoA lyase 523 e-147
ref|NP_001068600.1| 3-hydroxymethyl-3-methylglutaryl-Coenzy... 523 e-147
ref|XP_001504254.1| PREDICTED: similar to interleukin 13 re... 523 e-146
sp|P38060|HMGCL_MOUSE Hydroxymethylglutaryl-CoA lyase, mito... 521 e-146
ref|XP_535360.2| PREDICTED: similar to Hydroxymethylglutary... 509 e-143
ref|XP_513200.2| PREDICTED: similar to 3-hydroxymethyl-3-me... 503 e-141
gb|AAB19099.1| hydroxymethylglutaryl-CoA lyase 503 e-140
emb|CAI23161.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A... 498 e-139
ref|XP_001166216.1| PREDICTED: similar to 3-hydroxymethyl-3... 497 e-139
pdb|2CW6|A Chain A, Crystal Structure Of Human Hmg-Coa Lyas... 495 e-138
ref|NP_001085152.1| hypothetical protein LOC432233 [Xenopus... 491 e-137
ref|XP_417834.1| PREDICTED: similar to Hydroxymethylglutary... 490 e-137
ref|XP_001104722.1| PREDICTED: 3-hydroxymethyl-3-methylglut... 488 e-136
ref|NP_061909.2| 3-hydroxymethyl-3-methylglutaryl-Coenzyme ... 488 e-136
ref|XP_538973.2| PREDICTED: similar to 3-hydroxymethyl-3-me... 487 e-136
ref|XP_001363832.1| PREDICTED: similar to alpha-2-macroglob... 486 e-136
ref|NP_957509.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme ... 485 e-135
ref|XP_001499476.1| PREDICTED: similar to 3-hydroxymethyl-3... 485 e-135
ref|NP_001035865.1| 3-hydroxymethyl-3-methylglutaryl-Coenzy... 482 e-134
ref|XP_001105003.1| PREDICTED: similar to 3-hydroxymethyl-3... 480 e-134
gb|EDL77774.1| similar to 3-hydroxymethyl-3-methylglutaryl-... 480 e-134
emb|CAG09900.1| unnamed protein product [Tetraodon nigrovir... 480 e-134
ref|NP_776092.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme ... 479 e-133
ref|NP_001103870.1| hypothetical protein LOC571388 [Danio r... 477 e-133
ref|XP_001196745.1| PREDICTED: similar to MGC82338 protein ... 476 e-132
gb|AAL89669.1|AF411956_10 hydroxymethylglutaryl-CoA lyase [... 475 e-132
ref|XP_419903.1| PREDICTED: similar to 3-hydroxymethyl-3-me... 475 e-132
gb|ABA95738.2| Hydroxymethylglutaryl-CoA lyase, mitochondri... 473 e-132
ref|XP_615612.3| PREDICTED: similar to 3-hydroxymethyl-3-me... 471 e-131
ref|NP_001065695.1| Os11g0137200 [Oryza sativa (japonica cu... 471 e-131
sp|P35915|HMGCL_CHICK Hydroxymethylglutaryl-CoA lyase (HMG-... 471 e-131
ref|XP_001371535.1| PREDICTED: similar to 3-hydroxymethyl-3... 469 e-130
ref|XP_001252308.1| PREDICTED: similar to 3-hydroxymethyl-3... 467 e-130
ref|XP_345954.2| PREDICTED: similar to 3-hydroxymethyl-3-me... 467 e-130
ref|XP_001166145.1| PREDICTED: similar to 3-hydroxymethyl-3... 466 e-130
ref|ZP_02912623.1| pyruvate carboxyltransferase [Geobacillu... 465 e-129
dbj|BAE71196.1| putative hydroxymethylglutaryl-CoA lyase [T... 464 e-129
emb|CAO67270.1| unnamed protein product [Vitis vinifera] 462 e-128
ref|NP_001066093.1| Os12g0134000 [Oryza sativa (japonica cu... 462 e-128
gb|AAA92728.1| hydroxymethylglutaryl-CoA lyase 461 e-128
ref|NP_565629.1| hydroxymethylglutaryl-CoA lyase, putative ... 460 e-128
ref|XP_001767580.1| predicted protein [Physcomitrella paten... 459 e-127
ref|YP_001502656.1| pyruvate carboxyltransferase [Shewanell... 457 e-127
ref|NP_850087.1| hydroxymethylglutaryl-CoA lyase, putative ... 456 e-126
ref|YP_268341.1| hydroxymethylglutaryl-CoA lyase [Colwellia... 456 e-126
ref|XP_638884.1| hydroxymethylglutaryl-CoA lyase [Dictyoste... 456 e-126
gb|EAZ11369.1| hypothetical protein OsJ_001194 [Oryza sativ... 454 e-126
ref|XP_001355781.1| GA10298-PA [Drosophila pseudoobscura] >... 454 e-126
ref|NP_609089.1| CG10399 CG10399-PA [Drosophila melanogaste... 454 e-126
ref|XP_314824.4| AGAP008717-PA [Anopheles gambiae str. PEST... 454 e-126
ref|YP_283315.1| Pyruvate carboxyltransferase [Dechloromona... 453 e-126
gb|EAY73450.1| hypothetical protein OsI_001297 [Oryza sativ... 453 e-126
gb|AAY55779.1| IP10508p [Drosophila melanogaster] 452 e-125
ref|ZP_01894930.1| 3-hydroxymethylglutaryl-CoA or malyl-CoA... 451 e-125
ref|YP_001187522.1| hydroxymethylglutaryl-CoA lyase [Pseudo... 451 e-125
ref|XP_001638492.1| predicted protein [Nematostella vectens... 451 e-125
ref|YP_001250583.1| hydroxymethylglutaryl-CoA lyase [Legion... 451 e-125
ref|YP_001675115.1| pyruvate carboxyltransferase [Shewanell... 451 e-125
ref|ZP_01165306.1| Pyruvate carboxyltransferase [Oceanospir... 450 e-125
ref|ZP_01076043.1| 3-hydroxymethylglutaryl-CoA or malyl-CoA... 449 e-125
gb|EEJ81164.1| hydroxymethylglutaryl-CoA lyase [Kangiella k... 449 e-124
ref|ZP_01617610.1| hydroxymethylglutaryl-CoA lyase [marine ... 449 e-124
ref|YP_751410.1| pyruvate carboxyltransferase [Shewanella f... 449 e-124
ref|ZP_02157638.1| hydroxymethylglutaryl-CoA lyase [Shewane... 449 e-124
ref|YP_095856.1| hydroxymethylglutaryl-CoA lyase [Legionell... 448 e-124
ref|YP_261034.1| hydroxymethylglutaryl-CoA lyase [Pseudomon... 448 e-124
ref|YP_001173695.1| hydroxymethylglutaryl-CoA lyase [Pseudo... 448 e-124
ref|YP_349383.1| hydroxymethylglutaryl-CoA lyase [Pseudomon... 447 e-124
ref|YP_959392.1| pyruvate carboxyltransferase [Marinobacter... 447 e-124
ref|YP_127132.1| hypothetical protein lpl1794 [Legionella p... 447 e-124
ref|YP_001094699.1| pyruvate carboxyltransferase [Shewanell... 447 e-124
ref|YP_001555403.1| pyruvate carboxyltransferase [Shewanell... 447 e-124
ref|ZP_01043050.1| Hydroxymethylglutaryl-CoA lyase [Idiomar... 447 e-124
ref|ZP_01840459.1| pyruvate carboxyltransferase [Shewanella... 447 e-124
ref|YP_001473193.1| pyruvate carboxyltransferase [Shewanell... 447 e-124
ref|NP_800125.1| hydroxymethylglutaryl-CoA lyase [Vibrio pa... 447 e-124
ref|NP_001042696.1| Os01g0269000 [Oryza sativa (japonica cu... 446 e-124
ref|YP_001267557.1| hydroxymethylglutaryl-CoA lyase [Pseudo... 446 e-124
ref|YP_001051186.1| pyruvate carboxyltransferase [Shewanell... 446 e-123
ref|YP_001125565.1| hydroxymethylglutaryl-CoA lyase [Geobac... 446 e-123
ref|ZP_01260765.1| hydroxymethylglutaryl-CoA lyase [Vibrio ... 445 e-123
gb|ABN08537.1| Pyruvate carboxyltransferase [Medicago trunc... 445 e-123
dbj|BAD81168.1| putative hydroxymethylglutaryl-CoA lyase [O... 445 e-123
ref|YP_001367047.1| pyruvate carboxyltransferase [Shewanell... 444 e-123
emb|CAO18214.1| unnamed protein product [Vitis vinifera] 444 e-123
ref|NP_745677.1| hydroxymethylglutaryl-CoA lyase [Pseudomon... 444 e-123
ref|NP_792548.1| hydroxymethylglutaryl-CoA lyase [Pseudomon... 444 e-123
ref|XP_001606475.1| PREDICTED: similar to hydroxymethylglut... 443 e-122
ref|YP_001668619.1| pyruvate carboxyltransferase [Pseudomon... 442 e-122
ref|YP_235548.1| hydroxymethylglutaryl-CoA lyase [Pseudomon... 442 e-122
ref|YP_001761592.1| pyruvate carboxyltransferase [Shewanell... 442 e-122
ref|YP_525054.1| pyruvate carboxyltransferase [Rhodoferax f... 441 e-122
ref|YP_001348638.1| hydroxymethylglutaryl-CoA lyase [Pseudo... 441 e-122
ref|ZP_01989357.1| hydroxymethylglutaryl-CoA lyase [Vibrio ... 441 e-122
ref|ZP_01475929.1| hypothetical protein VEx2w_02001435 [Vib... 441 e-122
ref|YP_001748815.1| pyruvate carboxyltransferase [Pseudomon... 441 e-122
ref|YP_927235.1| pyruvate carboxyltransferase [Shewanella a... 441 e-122
ref|NP_800639.1| putative hydroxymethylglutaryl-CoA lyase [... 440 e-122
ref|YP_662491.1| pyruvate carboxyltransferase [Pseudoaltero... 440 e-122
ref|YP_980720.1| pyruvate carboxyltransferase [Polaromonas ... 439 e-122
ref|YP_001424886.1| hydroxymethylglutaryl-CoA lyase [Coxiel... 439 e-121
ref|YP_147454.1| hydroxymethylglutaryl-CoA lyase [Geobacill... 439 e-121
ref|YP_274820.1| hydroxymethylglutaryl-CoA lyase [Pseudomon... 439 e-121
pdb|2FTP|A Chain A, Crystal Structure Of Hydroxymethylgluta... 439 e-121
ref|ZP_02194290.1| hydroxymethylglutaryl-CoA lyase [Vibrio ... 439 e-121
ref|NP_250701.1| hydroxymethylglutaryl-CoA lyase [Pseudomon... 439 e-121
gb|AAT51198.1| PA2011 [synthetic construct] 439 e-121
ref|YP_550945.1| pyruvate carboxyltransferase [Polaromonas ... 439 e-121
ref|ZP_01738810.1| 3-hydroxymethylglutaryl-CoA or malyl-CoA... 439 e-121
ref|ZP_01990241.1| hydroxymethylglutaryl-CoA lyase [Vibrio ... 439 e-121
ref|ZP_00969554.1| COG0119: Isopropylmalate/homocitrate/cit... 439 e-121
ref|ZP_01985852.1| hydroxymethylglutaryl-CoA lyase [Vibrio ... 439 e-121
ref|XP_001025212.1| HMGL-like family protein [Tetrahymena t... 438 e-121
ref|ZP_01946497.2| hydroxymethylglutaryl-CoA lyase [Coxiell... 438 e-121
ref|ZP_01219333.1| putative hydroxymethylglutaryl-CoA lyase... 438 e-121
ref|YP_987942.1| pyruvate carboxyltransferase [Acidovorax s... 438 e-121
ref|YP_738441.1| pyruvate carboxyltransferase [Shewanella s... 438 e-121
ref|NP_819552.1| hydroxymethylglutaryl-CoA lyase [Coxiella ... 438 e-121
ref|XP_001654565.1| hydroxymethylglutaryl-coa lyase [Aedes ... 438 e-121
ref|YP_001596451.1| hydroxymethylglutaryl-CoA lyase [Coxiel... 437 e-121
ref|ZP_01109008.1| hydroxymethylglutaryl-CoA lyase [Alterom... 437 e-121
ref|ZP_00974724.1| COG0119: Isopropylmalate/homocitrate/cit... 437 e-121
ref|XP_973049.1| PREDICTED: similar to CG10399-PA [Triboliu... 436 e-121
ref|XP_001843753.1| hydroxymethylglutaryl-CoA lyase [Culex ... 436 e-121
ref|ZP_01477180.1| hypothetical protein VEx2w_02000016 [Vib... 436 e-120
ref|YP_159665.1| 3-hydroxymethylglutaryl-CoA or malyl-CoA l... 436 e-120
ref|ZP_01899775.1| Hydroxymethylglutaryl-CoA lyase [Moritel... 436 e-120
ref|YP_563253.1| Hydroxymethylglutaryl-CoA lyase [Shewanell... 436 e-120
ref|ZP_00975701.1| COG0119: Isopropylmalate/homocitrate/cit... 436 e-120
ref|ZP_00056425.1| COG0119: Isopropylmalate/homocitrate/cit... 436 e-120
ref|YP_001447608.1| hydroxymethylglutaryl-CoA lyase [Vibrio... 435 e-120
ref|NP_717501.1| hydroxymethylglutaryl-CoA lyase [Shewanell... 435 e-120
ref|NP_937105.1| putative hydroxymethylglutaryl-CoA lyase [... 435 e-120
ref|YP_001856404.1| pyruvate carboxyltransferase [Burkholde... 434 e-120
ref|ZP_01522450.1| pyruvate carboxyltransferase [Comamonas ... 434 e-120
ref|YP_001633348.1| hydroxymethylglutaryl-CoA lyase [Bordet... 434 e-120
ref|YP_972663.1| pyruvate carboxyltransferase [Acidovorax a... 434 e-120
ref|YP_608548.1| hydroxymethylglutaryl-CoA lyase [Pseudomon... 433 e-120
ref|XP_001748375.1| predicted protein [Monosiga brevicollis... 433 e-120
ref|YP_001351814.1| hydroxymethylglutaryl-CoA lyase [Janthi... 433 e-120
ref|NP_389705.1| hydroxymethylglutaryl-CoA lyase [Bacillus ... 433 e-120
ref|YP_734454.1| pyruvate carboxyltransferase [Shewanella s... 433 e-120
ref|YP_001894089.1| pyruvate carboxyltransferase [Burkholde... 433 e-119
ref|YP_784735.1| hydroxymethylglutaryl-CoA lyase [Bordetell... 433 e-119
ref|YP_343884.1| Pyruvate carboxyltransferase [Nitrosococcu... 432 e-119
ref|YP_001566977.1| pyruvate carboxyltransferase [Delftia a... 432 e-119
ref|YP_132791.1| putative hydroxymethylglutaryl-CoA lyase [... 432 e-119
ref|YP_001714131.1| putative Hydroxymethylglutaryl-CoA lyas... 432 e-119
ref|YP_001846066.1| Isopropylmalate/homocitrate/citramalate... 432 e-119
ref|YP_869307.1| pyruvate carboxyltransferase [Shewanella s... 431 e-119
ref|YP_079304.1| putative hydroxymethylglutaryl-CoA lyase [... 431 e-119
ref|ZP_01260030.1| putative hydroxymethylglutaryl-CoA lyase... 431 e-119
ref|ZP_01102127.1| hydroxymethylglutaryl-CoA lyase [gamma p... 431 e-119
ref|ZP_01707035.1| pyruvate carboxyltransferase [Shewanella... 431 e-119
ref|ZP_00417242.1| HMG-CoA lyase-like [Azotobacter vineland... 431 e-119
ref|YP_001696645.1| Hydroxymethylglutaryl-CoA lyase [Lysini... 431 e-119
ref|ZP_01723191.1| hydroxymethylglutaryl-CoA lyase [Bacillu... 430 e-119
ref|YP_963688.1| pyruvate carboxyltransferase [Shewanella s... 429 e-118
ref|YP_002773338.1| hydroxymethylglutaryl-CoA lyase [Brevib... 429 e-118
ref|YP_556781.1| hydroxymethylglutaryl-CoA lyase [Burkholde... 428 e-118
ref|ZP_02882797.1| pyruvate carboxyltransferase [Burkholder... 428 e-118
ref|YP_294379.1| hydroxymethylglutaryl-CoA lyase [Ralstonia... 428 e-118
ref|ZP_02006287.1| pyruvate carboxyltransferase [Ralstonia ... 427 e-118
ref|NP_001040133.1| hydroxymethylglutaryl-CoA lyase [Bombyx... 427 e-118
ref|YP_001183239.1| pyruvate carboxyltransferase [Shewanell... 426 e-118
gb|AAF32339.1|AF218939_7 hydroxymethylglutaryl-CoA lyase [B... 426 e-118
ref|YP_001897709.1| pyruvate carboxyltransferase [Ralstonia... 425 e-117
ref|ZP_02462060.1| hydroxymethylglutaryl-CoA lyase [Burkhol... 425 e-117
ref|ZP_02354193.1| hydroxymethylglutaryl-CoA lyase [Burkhol... 425 e-117
ref|YP_435092.1| Isopropylmalate/homocitrate/citramalate sy... 425 e-117
ref|XP_001771511.1| predicted protein [Physcomitrella paten... 425 e-117
ref|YP_582762.1| hydroxymethylglutaryl-CoA lyase [Ralstonia... 424 e-117
ref|YP_106960.1| hydroxymethylglutaryl-CoA lyase [Burkholde... 424 e-117
ref|NP_882598.1| hydroxymethylglutaryl-CoA lyase [Bordetell... 424 e-117
ref|YP_001809562.1| pyruvate carboxyltransferase [Burkholde... 424 e-117
ref|YP_155267.1| Hydroxymethylglutaryl-CoA lyase [Idiomarin... 424 e-117
ref|NP_879404.1| hydroxymethylglutaryl-CoA lyase [Bordetell... 424 e-117
ref|YP_001280953.1| pyruvate carboxyltransferase [Psychroba... 424 e-117
ref|ZP_02911146.1| pyruvate carboxyltransferase [Burkholder... 424 e-117
ref|YP_774897.1| hydroxymethylglutaryl-CoA lyase [Burkholde... 423 e-117
ref|ZP_00946303.1| Hydroxymethylglutaryl-CoA lyase [Ralston... 423 e-117
pdb|1YDO|A Chain A, Crystal Structure Of The Bacillis Subti... 423 e-117
ref|YP_339966.1| Hydroxymethylglutaryl-CoA lyase (HMG-CoA l... 423 e-116
ref|XP_001426433.1| hypothetical protein GSPATT00029666001 ... 423 e-116
ref|ZP_00987697.1| COG0119: Isopropylmalate/homocitrate/cit... 422 e-116
ref|YP_001645201.1| pyruvate carboxyltransferase [Bacillus ... 422 e-116
ref|ZP_02893054.1| pyruvate carboxyltransferase [Burkholder... 422 e-116
ref|ZP_01308647.1| hydroxymethylglutaryl-CoA lyase [Oceanob... 422 e-116
ref|ZP_03824456.1| hydroxymethylglutaryl-CoA lyase (3-hydro... 422 e-116
ref|YP_001375099.1| pyruvate carboxyltransferase [Bacillus ... 422 e-116
ref|ZP_02842380.1| pyruvate carboxyltransferase [Thauera sp... 422 e-116
ref|YP_420036.1| Isopropylmalate/homocitrate/citramalate sy... 422 e-116
ref|ZP_00980803.1| COG0119: Isopropylmalate/homocitrate/cit... 422 e-116
ref|YP_001791147.1| pyruvate carboxyltransferase [Leptothri... 422 e-116
emb|CAM76025.1| Pyruvate carboxyltransferase [Magnetospiril... 422 e-116
ref|YP_001766260.1| pyruvate carboxyltransferase [Burkholde... 421 e-116
ref|YP_724706.1| hydroxymethylglutaryl-CoA lyase [Ralstonia... 421 e-116
ref|ZP_01869471.1| putative hydroxymethylglutaryl-CoA lyase... 421 e-116
ref|YP_001581136.1| pyruvate carboxyltransferase [Burkholde... 421 e-116
ref|ZP_02523119.1| hydroxymethylglutaryl-CoA lyase [Bacillu... 421 e-116
ref|NP_978859.1| hydroxymethylglutaryl-CoA lyase [Bacillus ... 421 e-116
ref|ZP_01696476.1| pyruvate carboxyltransferase [Bacillus c... 420 e-116
ref|ZP_01614249.1| Hydroxymethylglutaryl-CoA lyase (HMG-CoA... 420 e-116
ref|YP_036656.1| hydroxymethylglutaryl-CoA lyase [Bacillus ... 420 e-116
ref|YP_370547.1| hydroxymethylglutaryl-CoA lyase [Burkholde... 420 e-116
ref|NP_844918.1| hydroxymethylglutaryl-CoA lyase [Bacillus ... 420 e-116
ref|ZP_02876504.1| 3-hydroxy-3-methylglutarate-CoA lyase [B... 420 e-116
ref|NP_832245.1| hydroxymethylglutaryl-CoA lyase [Bacillus ... 420 e-116
ref|ZP_02256685.1| hydroxymethylglutaryl-CoA lyase [Bacillu... 419 e-115
ref|YP_083878.1| hydroxymethylglutaryl-CoA lyase [Bacillus ... 419 e-115
ref|YP_440871.1| hydroxymethylglutaryl-CoA lyase [Burkholde... 419 e-115
ref|YP_001524912.1| hydroxymethylglutaryl-CoA lyase [Azorhi... 419 e-115
ref|ZP_02600521.1| hydroxymethylglutaryl-CoA lyase [Bacillu... 419 e-115
ref|YP_263616.1| probable hydroxymethylglutaryl-coenzyme A ... 419 e-115
ref|ZP_02582523.1| hydroxymethylglutaryl-CoA lyase [Bacillu... 419 e-115
ref|XP_001770817.1| predicted protein [Physcomitrella paten... 419 e-115
ref|YP_622219.1| hydroxymethylglutaryl-CoA lyase [Burkholde... 418 e-115
ref|YP_001795524.1| HYDROXYMETHYLGLUTARYL-COA LYASE PROTEIN... 418 e-115
ref|ZP_01224251.1| hydroxymethylglutaryl-CoA lyase [marine ... 418 e-115
ref|ZP_02372445.1| hydroxymethylglutaryl-CoA lyase [Burkhol... 418 e-115
ref|YP_579611.1| pyruvate carboxyltransferase [Psychrobacte... 417 e-115
ref|ZP_01644741.1| pyruvate carboxyltransferase [Stenotroph... 417 e-115
ref|YP_001120874.1| hydroxymethylglutaryl-CoA lyase [Burkho... 417 e-115
ref|ZP_02377633.1| hydroxymethylglutaryl-CoA lyase [Burkhol... 417 e-115
ref|ZP_00240861.1| hydroxymethylglutaryl-CoA lyase [Bacillu... 417 e-115
ref|ZP_01133898.1| Hydroxymethylglutaryl-CoA lyase (HMG-CoA... 416 e-115
ref|YP_934568.1| hydroxymethylglutaryl-CoA lyase [Azoarcus ... 416 e-114
ref|YP_001421429.1| YngG [Bacillus amyloliquefaciens FZB42]... 416 e-114
ref|ZP_01766709.1| hydroxymethylglutaryl-CoA lyase [Burkhol... 415 e-114
ref|ZP_01112572.1| hydroxymethylglutaryl-CoA lyase [Reineke... 415 e-114
ref|NP_357129.2| hydroxymethylglutaryl-CoA lyase [Agrobacte... 415 e-114
ref|NP_642177.1| hydroxymethylglutaryl-CoA lyase [Xanthomon... 415 e-114
ref|ZP_01233364.1| putative hydroxymethylglutaryl-CoA lyase... 415 e-114
ref|ZP_01722603.1| hydroxymethylglutaryl-CoA lyase [Bacillu... 415 e-114
ref|XP_501226.1| hypothetical protein [Yarrowia lipolytica]... 415 e-114
gb|EDP48120.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A ... 414 e-114
ref|YP_001022542.1| hydroxymethylglutaryl-CoA lyase [Methyl... 414 e-114
ref|YP_001903524.1| Hydroxymethylglutaryl-CoA lyase [Xantho... 414 e-114
ref|YP_001416756.1| pyruvate carboxyltransferase [Xanthobac... 414 e-114
ref|YP_386231.1| Pyruvate carboxyltransferase [Geobacter me... 414 e-114
ref|NP_518382.1| hydroxymethylglutaryl-CoA lyase [Ralstonia... 414 e-114
ref|XP_001122226.1| PREDICTED: similar to CG10399-PA [Apis ... 413 e-114
ref|YP_295676.1| hydroxymethylglutaryl-CoA lyase [Ralstonia... 413 e-114
ref|ZP_01159378.1| putative hydroxymethylglutaryl-CoA lyase... 413 e-114
ref|YP_995316.1| pyruvate carboxyltransferase [Verminephrob... 413 e-113
ref|YP_631935.1| hydroxymethylglutaryl-CoA lyase [Myxococcu... 412 e-113
ref|XP_746760.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme ... 412 e-113
ref|ZP_01913861.1| hydroxymethylglutaryl-CoA lyase [Limnoba... 411 e-113
ref|XP_663886.1| hypothetical protein AN6282.2 [Aspergillus... 410 e-113
ref|ZP_03881357.1| hydroxymethylglutaryl-CoA lyase [Haliang... 410 e-113
ref|ZP_01549388.1| hydroxymethylglutaryl-CoA lyase [Stappia... 409 e-112
ref|YP_001108593.1| hydroxymethylglutaryl-CoA lyase [Saccha... 409 e-112
ref|YP_001614964.1| Hydroxymethylglutaryl-CoA lyase [Sorang... 407 e-112
ref|YP_002796051.1| Hydroxymethylglutaryl-CoA lyase [Lariba... 407 e-112
gb|EEJ95321.1| hydroxymethylglutaryl-CoA lyase [Thermomonos... 406 e-111
ref|ZP_01128907.1| Pyruvate carboxyltransferase [Nitrococcu... 406 e-111
ref|NP_692264.1| hydroxymethylglutaryl-CoA lyase [Oceanobac... 406 e-111
ref|ZP_01736989.1| Pyruvate carboxyltransferase [Marinobact... 406 e-111
ref|NP_637197.1| hydroxymethylglutaryl-CoA lyase [Xanthomon... 405 e-111
ref|YP_001240021.1| hydroxymethylglutaryl-CoA lyase [Bradyr... 405 e-111
ref|YP_725743.1| Hydroxymethylglutaryl-CoA lyase [Ralstonia... 405 e-111
ref|NP_826453.1| hydroxymethylglutaryl-CoA lyase [Streptomy... 405 e-111
ref|YP_001487014.1| hydroxymethylglutaryl-CoA lyase [Bacill... 405 e-111
emb|CAK32536.1| Hydroxymethylglutaryl-CoA lyase [uncultured... 404 e-111
ref|YP_363628.1| hydroxymethylglutaryl-CoA lyase [Xanthomon... 404 e-111
ref|XP_001667667.1| Hypothetical protein CBG22170 [Caenorha... 404 e-111
ref|YP_001205681.1| hydroxymethylglutaryl-CoA lyase (HMG-Co... 404 e-111
ref|YP_001141730.1| hydroxymethylglutaryl-CoA lyase [Aeromo... 404 e-111
ref|NP_490889.1| Y71G12B.10 [Caenorhabditis elegans] >gi|14... 403 e-111
ref|NP_970304.1| hydroxymethylglutaryl-CoA lyase [Bdellovib... 403 e-110
ref|XP_001262809.1| 3-hydroxymethyl-3-methylglutaryl-Coenzy... 402 e-110
ref|NP_771062.1| hydroxymethylglutaryl-CoA lyase [Bradyrhiz... 402 e-110
ref|ZP_03817872.1| hydroxymethylglutaryl-CoA lyase [Actinos... 402 e-110
ref|YP_856604.1| hydroxymethylglutaryl-CoA lyase [Aeromonas... 401 e-110
ref|YP_486545.1| Pyruvate carboxyltransferase [Rhodopseudom... 401 e-110
ref|ZP_01913223.1| hydroxymethylglutaryl-CoA lyase [Plesioc... 401 e-110
ref|ZP_03862034.1| hydroxymethylglutaryl-CoA lyase [Kribbel... 401 e-110
ref|XP_001703205.1| hypothetical protein CHLREDRAFT_195057 ... 401 e-110
ref|NP_901429.1| hydroxymethylglutaryl-CoA lyase [Chromobac... 400 e-110
ref|XP_963242.1| hydroxymethylglutaryl-CoA lyase [Neurospor... 400 e-110
ref|YP_001890635.1| pyruvate carboxyltransferase [Burkholde... 400 e-110
ref|YP_532647.1| pyruvate carboxyltransferase [Rhodopseudom... 399 e-109
gb|EEK05215.1| hydroxymethylglutaryl-CoA lyase [Alicyclobac... 398 e-109
ref|XP_001245768.1| hypothetical protein CIMG_05209 [Coccid... 397 e-109
ref|YP_799007.1| 2-isopropylmalate synthase [Leptospira bor... 397 e-109
ref|NP_242000.1| hydroxymethylglutaryl-CoA lyase [Bacillus ... 397 e-109
ref|YP_569667.1| pyruvate carboxyltransferase [Rhodopseudom... 397 e-109
ref|ZP_02882110.1| pyruvate carboxyltransferase [Burkholder... 397 e-109
ref|NP_947882.1| 3-hydroxy-3-methylglutaryl-CoA lyase [Rhod... 397 e-109
ref|XP_001825445.1| hypothetical protein [Aspergillus oryza... 396 e-108
ref|YP_001340336.1| pyruvate carboxyltransferase [Marinomon... 396 e-108
Sequences not found previously or not previously below threshold:
>ref|NP_000182.2| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase
(hydroxymethylglutaricaciduria) [Homo sapiens]
sp|P35914|HMGCL_HUMAN Hydroxymethylglutaryl-CoA lyase, mitochondrial precursor (HMG-CoA
lyase) (HL) (3-hydroxy-3-methylglutarate-CoA lyase)
gb|AAH10570.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase
(hydroxymethylglutaricaciduria) [Homo sapiens]
gb|AAP88794.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase
(hydroxymethylglutaricaciduria) [Homo sapiens]
emb|CAG33165.1| HMGCL [Homo sapiens]
gb|AAX31956.1| 3-hydroxymethyl-3-methylglutaryl-coenzyme A lyase [synthetic
construct]
gb|AAX31957.1| 3-hydroxymethyl-3-methylglutaryl-coenzyme A lyase [synthetic
construct]
gb|AAX31958.1| 3-hydroxymethyl-3-methylglutaryl-coenzyme A lyase [synthetic
construct]
gb|AAX31959.1| 3-hydroxymethyl-3-methylglutaryl-coenzyme A lyase [synthetic
construct]
gb|EAW95094.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase
(hydroxymethylglutaricaciduria), isoform CRA_a [Homo
sapiens]
gb|ABM83009.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase
(hydroxymethylglutaricaciduria) [synthetic construct]
gb|ABM86202.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase
(hydroxymethylglutaricaciduria) [synthetic construct]
Length = 325
Score = 536 bits (1381), Expect = e-150, Method: Composition-based stats.
Identities = 325/325 (100%), Positives = 325/325 (100%)
Query: 1 MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI
Sbjct: 1 MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
Query: 61 DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAG 120
DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAG
Sbjct: 61 DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAG 120
Query: 121 AKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
AKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI
Sbjct: 121 AKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
Query: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ
Sbjct: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
Query: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL
Sbjct: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
Query: 301 EAGNFICQALNRKTSSKVAQATCKL 325
EAGNFICQALNRKTSSKVAQATCKL
Sbjct: 301 EAGNFICQALNRKTSSKVAQATCKL 325
>gb|AAA92733.1| hydroxymethylglutaryl-CoA lyase [Homo sapiens]
Length = 325
Score = 534 bits (1377), Expect = e-150, Method: Composition-based stats.
Identities = 324/325 (99%), Positives = 324/325 (99%)
Query: 1 MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI
Sbjct: 1 MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
Query: 61 DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAG 120
DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAG
Sbjct: 61 DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAG 120
Query: 121 AKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
AKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI
Sbjct: 121 AKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
Query: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ
Sbjct: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
Query: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
AL NTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL
Sbjct: 241 ALTNTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
Query: 301 EAGNFICQALNRKTSSKVAQATCKL 325
EAGNFICQALNRKTSSKVAQATCKL
Sbjct: 301 EAGNFICQALNRKTSSKVAQATCKL 325
>ref|XP_001166273.1| PREDICTED: 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase
(hydroxymethylglutaricaciduria) isoform 3 [Pan
troglodytes]
Length = 325
Score = 534 bits (1376), Expect = e-150, Method: Composition-based stats.
Identities = 324/325 (99%), Positives = 325/325 (100%)
Query: 1 MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKL+
Sbjct: 1 MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLV 60
Query: 61 DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAG 120
DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAG
Sbjct: 61 DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAG 120
Query: 121 AKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
AKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI
Sbjct: 121 AKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
Query: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ
Sbjct: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
Query: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL
Sbjct: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
Query: 301 EAGNFICQALNRKTSSKVAQATCKL 325
EAGNFICQALNRKTSSKVAQATCKL
Sbjct: 301 EAGNFICQALNRKTSSKVAQATCKL 325
>sp|Q8HXZ6|HMGCL_MACFA Hydroxymethylglutaryl-CoA lyase, mitochondrial precursor (HMG-CoA
lyase) (HL) (3-hydroxy-3-methylglutarate-CoA lyase)
dbj|BAC20595.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase [Macaca
fascicularis]
Length = 325
Score = 533 bits (1373), Expect = e-149, Method: Composition-based stats.
Identities = 313/325 (96%), Positives = 315/325 (96%)
Query: 1 MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
MAAM KALPRRLVGLASLRAVSTSSM TLPK+VKIVEVGPRDGLQNEKNIVSTPVKIKLI
Sbjct: 1 MAAMTKALPRRLVGLASLRAVSTSSMDTLPKQVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
Query: 61 DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAG 120
DMLSEAGLSVIE TSFVSPKWVPQM DH EVLKGIQKFPGI YPVL PNLKGFEAAVAAG
Sbjct: 61 DMLSEAGLSVIEATSFVSPKWVPQMADHAEVLKGIQKFPGITYPVLIPNLKGFEAAVAAG 120
Query: 121 AKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
AKEV IFGAASELFTKKN+NCSIEESFQRFDAILKAAQSANISVRGYVSC LGCPYEGKI
Sbjct: 121 AKEVSIFGAASELFTKKNVNCSIEESFQRFDAILKAAQSANISVRGYVSCVLGCPYEGKI 180
Query: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVP AALAVHCHDTYGQ
Sbjct: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPPAALAVHCHDTYGQ 240
Query: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL
Sbjct: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
Query: 301 EAGNFICQALNRKTSSKVAQATCKL 325
EAGNFICQALNRKTSSKVAQATCKL
Sbjct: 301 EAGNFICQALNRKTSSKVAQATCKL 325
>sp|Q5R9E1|HMGCL_PONPY Hydroxymethylglutaryl-CoA lyase, mitochondrial precursor (HMG-CoA
lyase) (HL) (3-hydroxy-3-methylglutarate-CoA lyase)
emb|CAH91619.1| hypothetical protein [Pongo abelii]
Length = 325
Score = 532 bits (1371), Expect = e-149, Method: Composition-based stats.
Identities = 321/325 (98%), Positives = 322/325 (99%)
Query: 1 MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
MAAMRKA+PRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI
Sbjct: 1 MAAMRKAVPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
Query: 61 DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAG 120
DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAG
Sbjct: 61 DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAG 120
Query: 121 AKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
AKEV IFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI
Sbjct: 121 AKEVAIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
Query: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
SPAKVAEVTKK YSMGCYEISLGDTIGVGTPGIMK MLSAVMQEVPLAALAVHCHDTYGQ
Sbjct: 181 SPAKVAEVTKKLYSMGCYEISLGDTIGVGTPGIMKGMLSAVMQEVPLAALAVHCHDTYGQ 240
Query: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL
Sbjct: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
Query: 301 EAGNFICQALNRKTSSKVAQATCKL 325
EAGNFICQALNRKTSSKVAQATCKL
Sbjct: 301 EAGNFICQALNRKTSSKVAQATCKL 325
>ref|NP_077362.1| 3-hydroxy-3-methylglutaryl-Coenzyme A lyase [Rattus norvegicus]
sp|P97519|HMGCL_RAT Hydroxymethylglutaryl-CoA lyase, mitochondrial precursor (HMG-CoA
lyase) (HL) (3-hydroxy-3-methylglutarate-CoA lyase)
emb|CAA71148.1| 3-hydroxy-3-methylglutaryl CoA lyase [Rattus norvegicus]
gb|AAH61797.1| 3-hydroxy-3-methylglutaryl-Coenzyme A lyase [Rattus norvegicus]
gb|EDL80779.1| 3-hydroxy-3-methylglutaryl-Coenzyme A lyase, isoform CRA_a [Rattus
norvegicus]
Length = 325
Score = 528 bits (1361), Expect = e-148, Method: Composition-based stats.
Identities = 289/325 (88%), Positives = 311/325 (95%)
Query: 1 MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
MA +RKA P+RLVGLASLRA STSSMGTLPKRVKIVEVGPRDGLQNEK+IV TPVKIKLI
Sbjct: 1 MATVRKAFPQRLVGLASLRAASTSSMGTLPKRVKIVEVGPRDGLQNEKSIVPTPVKIKLI 60
Query: 61 DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAG 120
DMLSEAGL VIE TSFVSPKWVPQM DH++VLKGIQKFPGINYPVLTPN+KGFE AVAAG
Sbjct: 61 DMLSEAGLPVIEATSFVSPKWVPQMADHSDVLKGIQKFPGINYPVLTPNMKGFEEAVAAG 120
Query: 121 AKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
AKEV IFGAASELFT+KN+NCSIEESFQRFD +++AA++A+ISVRGYVSCALGCPYEGK+
Sbjct: 121 AKEVSIFGAASELFTRKNVNCSIEESFQRFDGVMQAARAASISVRGYVSCALGCPYEGKV 180
Query: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
SPAKVAEV KK YSMGCYEISLGDTIGVGTPG+MKDML+AV+ EVP+AALAVHCHDTYGQ
Sbjct: 181 SPAKVAEVAKKLYSMGCYEISLGDTIGVGTPGLMKDMLTAVLHEVPVAALAVHCHDTYGQ 240
Query: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
ALANTL+ALQMGVSVVDSSVAGLGGCPYA+GASGNLATEDLVYML GLGIHTGVNLQKLL
Sbjct: 241 ALANTLVALQMGVSVVDSSVAGLGGCPYAKGASGNLATEDLVYMLTGLGIHTGVNLQKLL 300
Query: 301 EAGNFICQALNRKTSSKVAQATCKL 325
EAG+FICQALNRKTSSKVAQATCKL
Sbjct: 301 EAGDFICQALNRKTSSKVAQATCKL 325
>ref|NP_032280.2| 3-hydroxy-3-methylglutaryl-Coenzyme A lyase [Mus musculus]
gb|AAH25440.1| Hmgcl protein [Mus musculus]
dbj|BAE32329.1| unnamed protein product [Mus musculus]
dbj|BAE20956.1| unnamed protein product [Mus musculus]
dbj|BAE26328.1| unnamed protein product [Mus musculus]
emb|CAM15901.1| 3-hydroxy-3-methylglutaryl-Coenzyme A lyase [Mus musculus]
gb|EDL29963.1| 3-hydroxy-3-methylglutaryl-Coenzyme A lyase [Mus musculus]
Length = 325
Score = 528 bits (1361), Expect = e-148, Method: Composition-based stats.
Identities = 286/325 (88%), Positives = 308/325 (94%)
Query: 1 MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
MA++RKA PRRLVGL SLRAVSTSSMGTLPK+VKIVEVGPRDGLQNEK+IV TPVKI+LI
Sbjct: 1 MASVRKAFPRRLVGLTSLRAVSTSSMGTLPKQVKIVEVGPRDGLQNEKSIVPTPVKIRLI 60
Query: 61 DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAG 120
DMLSEAGL VIE TSFVSPKWVPQM DH++VLKGIQKFPGINYPVLTPN+KGFE AVAAG
Sbjct: 61 DMLSEAGLPVIEATSFVSPKWVPQMADHSDVLKGIQKFPGINYPVLTPNMKGFEEAVAAG 120
Query: 121 AKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
AKEV +FGA SELFT+KN NCSIEESFQRF +++AAQ+A+ISVRGYVSCALGCPYEGK+
Sbjct: 121 AKEVSVFGAVSELFTRKNANCSIEESFQRFAGVMQAAQAASISVRGYVSCALGCPYEGKV 180
Query: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
SPAKVAEV KK YSMGCYEISLGDTIGVGTPG+MKDML+AVM EVP+ ALAVHCHDTYGQ
Sbjct: 181 SPAKVAEVAKKLYSMGCYEISLGDTIGVGTPGLMKDMLTAVMHEVPVTALAVHCHDTYGQ 240
Query: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
ALANTL+ALQMGVSVVDSSVAGLGGCPYA+GASGNLATEDLVYML GLGIHTGVNLQKLL
Sbjct: 241 ALANTLVALQMGVSVVDSSVAGLGGCPYAKGASGNLATEDLVYMLNGLGIHTGVNLQKLL 300
Query: 301 EAGNFICQALNRKTSSKVAQATCKL 325
EAG+FICQALNRKTSSKVAQATCKL
Sbjct: 301 EAGDFICQALNRKTSSKVAQATCKL 325
>dbj|BAE88248.1| unnamed protein product [Macaca fascicularis]
Length = 325
Score = 528 bits (1360), Expect = e-148, Method: Composition-based stats.
Identities = 312/325 (96%), Positives = 314/325 (96%)
Query: 1 MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
MAAM KALPRRLVGLASLRAVSTSSM TLPK+VKIVEVGPRDGLQN+KNIVSTPVKIKLI
Sbjct: 1 MAAMTKALPRRLVGLASLRAVSTSSMDTLPKQVKIVEVGPRDGLQNKKNIVSTPVKIKLI 60
Query: 61 DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAG 120
DMLSEAGLSVIE TSFVSPKWVPQM DH EVLKGIQKFPGI YPVL PNLKGFEAAVAAG
Sbjct: 61 DMLSEAGLSVIEATSFVSPKWVPQMADHAEVLKGIQKFPGITYPVLIPNLKGFEAAVAAG 120
Query: 121 AKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
AKEV IFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSC LGCPYEGKI
Sbjct: 121 AKEVSIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCVLGCPYEGKI 180
Query: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVP AALAVHCHDTYGQ
Sbjct: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPPAALAVHCHDTYGQ 240
Query: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQK L
Sbjct: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKPL 300
Query: 301 EAGNFICQALNRKTSSKVAQATCKL 325
EAGNFICQALNRKTSSKVAQATCKL
Sbjct: 301 EAGNFICQALNRKTSSKVAQATCKL 325
>dbj|BAE26056.1| unnamed protein product [Mus musculus]
Length = 325
Score = 527 bits (1358), Expect = e-148, Method: Composition-based stats.
Identities = 284/325 (87%), Positives = 306/325 (94%)
Query: 1 MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
MA++RKA PRRLVGL SLRAVSTSSMGTLPK+VKIVEVGPRDGLQNEK+IV TPVKI+LI
Sbjct: 1 MASVRKAFPRRLVGLTSLRAVSTSSMGTLPKQVKIVEVGPRDGLQNEKSIVPTPVKIRLI 60
Query: 61 DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAG 120
DMLSEAGL VIE TSFVSPKWVPQM DH++VLKGIQKFPGINYPVLTPN+KGFE AVAAG
Sbjct: 61 DMLSEAGLPVIEATSFVSPKWVPQMADHSDVLKGIQKFPGINYPVLTPNMKGFEEAVAAG 120
Query: 121 AKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
AKEV +FGA SELFT+KN NCSIEESFQRF +++AAQ+A+ISVRGYVSCALGCPYEGK+
Sbjct: 121 AKEVSVFGAVSELFTRKNANCSIEESFQRFAGVMQAAQAASISVRGYVSCALGCPYEGKV 180
Query: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
SPAKVAEV KK YSMGCYEISLGDTIGVGTP MKDML+AVM EVP+ ALAVHCHDTYGQ
Sbjct: 181 SPAKVAEVAKKLYSMGCYEISLGDTIGVGTPDXMKDMLTAVMHEVPVTALAVHCHDTYGQ 240
Query: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
ALANTL+ALQMGVSVV+SSVAGLGGCPYA+GASGNLATEDLVYML GLGIHTGVNLQKLL
Sbjct: 241 ALANTLVALQMGVSVVNSSVAGLGGCPYAKGASGNLATEDLVYMLNGLGIHTGVNLQKLL 300
Query: 301 EAGNFICQALNRKTSSKVAQATCKL 325
EAG+FICQALNRKTSSKVAQATCKL
Sbjct: 301 EAGDFICQALNRKTSSKVAQATCKL 325
>gb|AAB03107.1| 3-hydroxy-3-methylglutaryl-CoA lyase
Length = 325
Score = 523 bits (1349), Expect = e-147, Method: Composition-based stats.
Identities = 284/325 (87%), Positives = 308/325 (94%)
Query: 1 MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
MA++RKA PRRLVGL SLRAVSTSSMGTLPK+VKIVEVGPRDGLQNEK+IV TPVKI+LI
Sbjct: 1 MASVRKAFPRRLVGLTSLRAVSTSSMGTLPKQVKIVEVGPRDGLQNEKSIVPTPVKIRLI 60
Query: 61 DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAG 120
D++SEAGL VIE TSFVSPKWVPQM DH++VLKGIQKFPGINYPVLTPN+KGFE AVAAG
Sbjct: 61 DIVSEAGLPVIEATSFVSPKWVPQMADHSDVLKGIQKFPGINYPVLTPNMKGFEEAVAAG 120
Query: 121 AKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
AKEV +FGA SELFT+KN NCSIEESFQRF +++AAQ+A+ISVRGYVSCALGCPYEGK+
Sbjct: 121 AKEVSVFGAVSELFTRKNANCSIEESFQRFAGVMQAAQAASISVRGYVSCALGCPYEGKV 180
Query: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
SPAKVAEV KK YSMGCYEISLGDTIGVGTPG+MKDML+AVM EVP+ ALAVHCHDTYGQ
Sbjct: 181 SPAKVAEVAKKLYSMGCYEISLGDTIGVGTPGLMKDMLTAVMHEVPVTALAVHCHDTYGQ 240
Query: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
ALANTL+ALQMGVSVVDSSVAGLGGCPYA+GASGNLATEDLVYML GLGIHTGVNLQKLL
Sbjct: 241 ALANTLVALQMGVSVVDSSVAGLGGCPYAKGASGNLATEDLVYMLNGLGIHTGVNLQKLL 300
Query: 301 EAGNFICQALNRKTSSKVAQATCKL 325
EAG+FICQALNRKTSSKVAQATCKL
Sbjct: 301 EAGDFICQALNRKTSSKVAQATCKL 325
>ref|NP_001068600.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase
(hydroxymethylglutaricaciduria) [Bos taurus]
sp|Q29448|HMGCL_BOVIN Hydroxymethylglutaryl-CoA lyase, mitochondrial precursor (HMG-CoA
lyase) (HL) (3-hydroxy-3-methylglutarate-CoA lyase)
gb|AAI18277.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase
(hydroxymethylglutaricaciduria) [Bos taurus]
Length = 325
Score = 523 bits (1348), Expect = e-147, Method: Composition-based stats.
Identities = 289/325 (88%), Positives = 305/325 (93%)
Query: 1 MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
MA ++K LPRRLVGLA+LRAVSTSS+GT PK+VKIVEVGPRDGLQNEKNIV TPVKIKLI
Sbjct: 1 MATVKKVLPRRLVGLATLRAVSTSSVGTFPKQVKIVEVGPRDGLQNEKNIVPTPVKIKLI 60
Query: 61 DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAG 120
DMLSEAGL V+E TSFVSPKWVPQM DH EVLKGIQKFPG+NYPVLTPN KGF+AAVAAG
Sbjct: 61 DMLSEAGLPVVEATSFVSPKWVPQMADHAEVLKGIQKFPGVNYPVLTPNFKGFQAAVAAG 120
Query: 121 AKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
AKEV IFGAASELFTKKNINCSI+ES QRFD ILKAA++A ISVRGYVSC LGCPYEGKI
Sbjct: 121 AKEVAIFGAASELFTKKNINCSIDESLQRFDEILKAARAAGISVRGYVSCVLGCPYEGKI 180
Query: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
SPAKVAEVTKK YSMGCYEISLGDTIGVGTPG MKDMLSAV+QEVP+ ALAVHCHDTYGQ
Sbjct: 181 SPAKVAEVTKKLYSMGCYEISLGDTIGVGTPGAMKDMLSAVLQEVPVTALAVHCHDTYGQ 240
Query: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
ALANTL ALQMGVSV+DSSVAGLGGCPYAQGASGNLATEDLVYML GLGIHTGVNLQKLL
Sbjct: 241 ALANTLTALQMGVSVMDSSVAGLGGCPYAQGASGNLATEDLVYMLAGLGIHTGVNLQKLL 300
Query: 301 EAGNFICQALNRKTSSKVAQATCKL 325
EAG FICQALNR+T+SKVAQATCKL
Sbjct: 301 EAGAFICQALNRRTNSKVAQATCKL 325
>ref|XP_001504254.1| PREDICTED: similar to interleukin 13 receptor alpha 1-binding
protein-1 [Equus caballus]
Length = 325
Score = 523 bits (1347), Expect = e-146, Method: Composition-based stats.
Identities = 296/325 (91%), Positives = 306/325 (94%)
Query: 1 MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
MA +RK LPRRL GLASLRAVSTSS+GT PKRVKIVEVGPRDGLQNEKNIV T +KIKLI
Sbjct: 1 MATVRKGLPRRLAGLASLRAVSTSSVGTFPKRVKIVEVGPRDGLQNEKNIVPTAMKIKLI 60
Query: 61 DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAG 120
DMLSEAGL VIE TSFVSPKWVPQM DHTEVLKGIQKFPGINYPVLTPN KGF+AAVAAG
Sbjct: 61 DMLSEAGLPVIEATSFVSPKWVPQMADHTEVLKGIQKFPGINYPVLTPNFKGFQAAVAAG 120
Query: 121 AKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
AKEV +FGAASELFTKKNINCSIEES QRF +LKAA++A+I VRGYVSCALGCPYEGKI
Sbjct: 121 AKEVAVFGAASELFTKKNINCSIEESIQRFGEVLKAARAASIPVRGYVSCALGCPYEGKI 180
Query: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
SPAKVAEVTKK YSMGCYEISLGDTIGVGTPG MKDMLSAVMQEVP+AALAVHCHDTYGQ
Sbjct: 181 SPAKVAEVTKKMYSMGCYEISLGDTIGVGTPGGMKDMLSAVMQEVPVAALAVHCHDTYGQ 240
Query: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYML GLGIHTGVNLQKLL
Sbjct: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLAGLGIHTGVNLQKLL 300
Query: 301 EAGNFICQALNRKTSSKVAQATCKL 325
EAG FICQALNRKTSSKVAQATCKL
Sbjct: 301 EAGTFICQALNRKTSSKVAQATCKL 325
>sp|P38060|HMGCL_MOUSE Hydroxymethylglutaryl-CoA lyase, mitochondrial precursor (HMG-CoA
lyase) (HL) (3-hydroxy-3-methylglutarate-CoA lyase)
pir||I57009 3-Hydroxy-3-methylglutaryl coenzyme A lyase - mouse
gb|AAB27965.1| 3-Hydroxy-3-methylglutaryl coenzyme A lyase; HL [Mus sp.]
Length = 325
Score = 521 bits (1342), Expect = e-146, Method: Composition-based stats.
Identities = 283/325 (87%), Positives = 305/325 (93%)
Query: 1 MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
MA++RKA PRRLVGL SLRAVSTSSMGTLPK+VKIVEVGPRDGLQNEK+IV TPVKI+LI
Sbjct: 1 MASVRKAFPRRLVGLTSLRAVSTSSMGTLPKQVKIVEVGPRDGLQNEKSIVPTPVKIRLI 60
Query: 61 DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAG 120
DMLSEAGL VIE TSFVSP WVPQM DH++VLKGIQKFPGINYPVLTPN+KGFE AVAAG
Sbjct: 61 DMLSEAGLPVIEATSFVSPNWVPQMADHSDVLKGIQKFPGINYPVLTPNMKGFEEAVAAG 120
Query: 121 AKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
AKEV +FGA SELFT+KN NCSIEESFQRF +++AAQ+A+ISVRGYVSCALGCPYEGK+
Sbjct: 121 AKEVSVFGAVSELFTRKNANCSIEESFQRFAGVMQAAQAASISVRGYVSCALGCPYEGKV 180
Query: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
SPAKVAEV KK YSMGCYEISLGDTIGVGTPG+MKDML+AVM EVP+ AL VHCHDT GQ
Sbjct: 181 SPAKVAEVAKKLYSMGCYEISLGDTIGVGTPGLMKDMLTAVMHEVPVTALGVHCHDTIGQ 240
Query: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
ALANTL+ALQMGVSVVDSSVAGLGGCPYA+GASGNLATEDLVYML GLGIHTGVNLQKLL
Sbjct: 241 ALANTLVALQMGVSVVDSSVAGLGGCPYAKGASGNLATEDLVYMLNGLGIHTGVNLQKLL 300
Query: 301 EAGNFICQALNRKTSSKVAQATCKL 325
EAG+FICQALNRKTSSKVAQATCKL
Sbjct: 301 EAGDFICQALNRKTSSKVAQATCKL 325
>ref|XP_535360.2| PREDICTED: similar to Hydroxymethylglutaryl-CoA lyase,
mitochondrial precursor (HMG-CoA lyase) (HL)
(3-hydroxy-3-methylglutarate-CoA lyase) isoform 1 [Canis
familiaris]
Length = 325
Score = 509 bits (1313), Expect = e-143, Method: Composition-based stats.
Identities = 283/325 (87%), Positives = 295/325 (90%)
Query: 1 MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
MAAMRK +PRRLVGLASLRAVST S+GT PK+VKIVEVG RDGLQNEKNIVST KIKLI
Sbjct: 1 MAAMRKVVPRRLVGLASLRAVSTFSLGTFPKQVKIVEVGARDGLQNEKNIVSTSTKIKLI 60
Query: 61 DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAG 120
DMLSEAGL VIE TSFVSPKWVPQM D EVLKGIQKFPGINYPVLTPN+KGF+AAVAAG
Sbjct: 61 DMLSEAGLPVIEATSFVSPKWVPQMADCAEVLKGIQKFPGINYPVLTPNIKGFQAAVAAG 120
Query: 121 AKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
AKEV IF AASE FTKKN NCSI+E QR D I +AAQ+A I VRGYVSC LGCPYEGKI
Sbjct: 121 AKEVTIFAAASEQFTKKNTNCSIDECLQRSDDIFRAAQAAGIPVRGYVSCVLGCPYEGKI 180
Query: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
SPAKV EV KK YSMGCYEISLGDTIGVGTPG+MKDMLSAVM EVP++ALAVHCHDTYGQ
Sbjct: 181 SPAKVVEVAKKIYSMGCYEISLGDTIGVGTPGVMKDMLSAVMHEVPVSALAVHCHDTYGQ 240
Query: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
ALANTLMALQMGVSVVDSSVAGLGGCPYA+GASGNLATEDLVYML GLGIHTGVNLQKLL
Sbjct: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYARGASGNLATEDLVYMLSGLGIHTGVNLQKLL 300
Query: 301 EAGNFICQALNRKTSSKVAQATCKL 325
EAG FICQALNRKTSSKVAQA CKL
Sbjct: 301 EAGTFICQALNRKTSSKVAQAACKL 325
>ref|XP_513200.2| PREDICTED: similar to 3-hydroxymethyl-3-methylglutaryl-Coenzyme A
lyase (hydroxymethylglutaricaciduria) isoform 4 [Pan
troglodytes]
Length = 316
Score = 503 bits (1297), Expect = e-141, Method: Composition-based stats.
Identities = 304/305 (99%), Positives = 305/305 (100%)
Query: 21 VSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPK 80
VSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKL+DMLSEAGLSVIETTSFVSPK
Sbjct: 12 VSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLVDMLSEAGLSVIETTSFVSPK 71
Query: 81 WVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNIN 140
WVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNIN
Sbjct: 72 WVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNIN 131
Query: 141 CSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEI 200
CSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEI
Sbjct: 132 CSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEI 191
Query: 201 SLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSV 260
SLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSV
Sbjct: 192 SLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSV 251
Query: 261 AGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQ 320
AGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQ
Sbjct: 252 AGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQ 311
Query: 321 ATCKL 325
ATCKL
Sbjct: 312 ATCKL 316
>gb|AAB19099.1| hydroxymethylglutaryl-CoA lyase
Length = 305
Score = 503 bits (1295), Expect = e-140, Method: Composition-based stats.
Identities = 304/305 (99%), Positives = 305/305 (100%)
Query: 21 VSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPK 80
VSTSSMGTLPKRVKIVEVGP+DGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPK
Sbjct: 1 VSTSSMGTLPKRVKIVEVGPQDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPK 60
Query: 81 WVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNIN 140
WVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNIN
Sbjct: 61 WVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNIN 120
Query: 141 CSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEI 200
CSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEI
Sbjct: 121 CSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEI 180
Query: 201 SLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSV 260
SLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSV
Sbjct: 181 SLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSV 240
Query: 261 AGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQ 320
AGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQ
Sbjct: 241 AGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQ 300
Query: 321 ATCKL 325
ATCKL
Sbjct: 301 ATCKL 305
>emb|CAI23161.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase
(hydroxymethylglutaricaciduria) [Homo sapiens]
gb|EAW95095.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase
(hydroxymethylglutaricaciduria), isoform CRA_b [Homo
sapiens]
Length = 300
Score = 498 bits (1284), Expect = e-139, Method: Composition-based stats.
Identities = 300/300 (100%), Positives = 300/300 (100%)
Query: 26 MGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQM 85
MGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQM
Sbjct: 1 MGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQM 60
Query: 86 GDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNINCSIEE 145
GDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNINCSIEE
Sbjct: 61 GDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNINCSIEE 120
Query: 146 SFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLGDT 205
SFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLGDT
Sbjct: 121 SFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLGDT 180
Query: 206 IGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGG 265
IGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGG
Sbjct: 181 IGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGG 240
Query: 266 CPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQATCKL 325
CPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQATCKL
Sbjct: 241 CPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQATCKL 300
>ref|XP_001166216.1| PREDICTED: similar to 3-hydroxymethyl-3-methylglutaryl-Coenzyme A
lyase (hydroxymethylglutaricaciduria) isoform 2 [Pan
troglodytes]
Length = 300
Score = 497 bits (1280), Expect = e-139, Method: Composition-based stats.
Identities = 299/300 (99%), Positives = 300/300 (100%)
Query: 26 MGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQM 85
MGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKL+DMLSEAGLSVIETTSFVSPKWVPQM
Sbjct: 1 MGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLVDMLSEAGLSVIETTSFVSPKWVPQM 60
Query: 86 GDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNINCSIEE 145
GDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNINCSIEE
Sbjct: 61 GDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNINCSIEE 120
Query: 146 SFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLGDT 205
SFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLGDT
Sbjct: 121 SFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLGDT 180
Query: 206 IGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGG 265
IGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGG
Sbjct: 181 IGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGG 240
Query: 266 CPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQATCKL 325
CPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQATCKL
Sbjct: 241 CPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQATCKL 300
>pdb|2CW6|A Chain A, Crystal Structure Of Human Hmg-Coa Lyase: Insights Into
Catalysis And The Molecular Basis For
Hydroxymethylglutaric Aciduria
pdb|2CW6|B Chain B, Crystal Structure Of Human Hmg-Coa Lyase: Insights Into
Catalysis And The Molecular Basis For
Hydroxymethylglutaric Aciduria
pdb|2CW6|C Chain C, Crystal Structure Of Human Hmg-Coa Lyase: Insights Into
Catalysis And The Molecular Basis For
Hydroxymethylglutaric Aciduria
pdb|2CW6|D Chain D, Crystal Structure Of Human Hmg-Coa Lyase: Insights Into
Catalysis And The Molecular Basis For
Hydroxymethylglutaric Aciduria
pdb|2CW6|E Chain E, Crystal Structure Of Human Hmg-Coa Lyase: Insights Into
Catalysis And The Molecular Basis For
Hydroxymethylglutaric Aciduria
pdb|2CW6|F Chain F, Crystal Structure Of Human Hmg-Coa Lyase: Insights Into
Catalysis And The Molecular Basis For
Hydroxymethylglutaric Aciduria
Length = 298
Score = 495 bits (1275), Expect = e-138, Method: Composition-based stats.
Identities = 298/298 (100%), Positives = 298/298 (100%)
Query: 28 TLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQMGD 87
TLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQMGD
Sbjct: 1 TLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQMGD 60
Query: 88 HTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNINCSIEESF 147
HTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNINCSIEESF
Sbjct: 61 HTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNINCSIEESF 120
Query: 148 QRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLGDTIG 207
QRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLGDTIG
Sbjct: 121 QRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLGDTIG 180
Query: 208 VGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGGCP 267
VGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGGCP
Sbjct: 181 VGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGGCP 240
Query: 268 YAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQATCKL 325
YAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQATCKL
Sbjct: 241 YAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQATCKL 298
>ref|NP_001085152.1| hypothetical protein LOC432233 [Xenopus laevis]
gb|AAH72247.1| MGC82338 protein [Xenopus laevis]
Length = 328
Score = 491 bits (1266), Expect = e-137, Method: Composition-based stats.
Identities = 234/325 (72%), Positives = 268/325 (82%), Gaps = 9/325 (2%)
Query: 10 RRLVG---------LASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
RRLV LA LR + + + + PK VKIVEVGPRDGLQNEK +V T VKI LI
Sbjct: 4 RRLVPVGWGAGWTPLAILRQIGSLPIQSFPKEVKIVEVGPRDGLQNEKTVVPTDVKIHLI 63
Query: 61 DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAG 120
+MLSEAGL IE TSFVSPKWVPQM DH V++GI+K+P I+YPVLTPNL GF+AAV G
Sbjct: 64 NMLSEAGLQAIEATSFVSPKWVPQMADHKNVMQGIKKYPNISYPVLTPNLTGFQAAVECG 123
Query: 121 AKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
AKEV IFGAASELF+KKNINCSI+ES QRF A++ A+ ANI VRGYVSC LGCPYEGK+
Sbjct: 124 AKEVAIFGAASELFSKKNINCSIDESLQRFKAVITEAKEANIPVRGYVSCVLGCPYEGKV 183
Query: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
+P+KVAEV K +SMGCYEISLGDTIGVGTPG M+DMLSAV+ VP ALAVHCHDTYGQ
Sbjct: 184 APSKVAEVAYKMFSMGCYEISLGDTIGVGTPGGMRDMLSAVLDVVPAKALAVHCHDTYGQ 243
Query: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
ALAN L+ALQMGV VVD+SVAGLGGCPYAQGASGN+ATED+VYML GLGI TG++L+KL
Sbjct: 244 ALANILVALQMGVQVVDASVAGLGGCPYAQGASGNVATEDVVYMLHGLGIQTGIDLKKLT 303
Query: 301 EAGNFICQALNRKTSSKVAQATCKL 325
EAG FIC+AL +K+ SKV+QA CKL
Sbjct: 304 EAGAFICKALGKKSHSKVSQAICKL 328
>ref|XP_417834.1| PREDICTED: similar to Hydroxymethylglutaryl-CoA lyase (HMG-CoA
lyase) (HL) (3-hydroxy-3-methylglutarate-CoA lyase)
[Gallus gallus]
Length = 319
Score = 490 bits (1263), Expect = e-137, Method: Composition-based stats.
Identities = 251/325 (77%), Positives = 288/325 (88%), Gaps = 6/325 (1%)
Query: 1 MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
MAA+R+ LPR V SLR VST++ P+RVK+VEVGPRDGLQNEK++V TPVKI+LI
Sbjct: 1 MAAVRRLLPRWAV---SLRPVSTAA---FPQRVKVVEVGPRDGLQNEKSVVPTPVKIRLI 54
Query: 61 DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAG 120
DMLSE GL VIE TSFVSP+WVPQM DH EV++GI K PG++YPVLTPNLKGF+AAVAAG
Sbjct: 55 DMLSETGLPVIEATSFVSPRWVPQMADHAEVMQGINKLPGVSYPVLTPNLKGFQAAVAAG 114
Query: 121 AKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
AKEV IFGAASELFTKKNINCSIEES +RF ++ AA++A+I VRGYVSC LGCPYEG I
Sbjct: 115 AKEVSIFGAASELFTKKNINCSIEESLERFSEVMNAARAASIPVRGYVSCVLGCPYEGNI 174
Query: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
S AKVAEV+KK YSMGCYEISLGDTIG+GTPG MK+ML+AVM+EVP+ ALAVHCHDTYGQ
Sbjct: 175 SAAKVAEVSKKMYSMGCYEISLGDTIGIGTPGSMKEMLAAVMKEVPVGALAVHCHDTYGQ 234
Query: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
ALAN L+ALQMGVSVVD+SVAGLGGCPYAQGASGN+ATEDLVYML GLGIHTGV+LQKL+
Sbjct: 235 ALANILVALQMGVSVVDASVAGLGGCPYAQGASGNVATEDLVYMLNGLGIHTGVDLQKLM 294
Query: 301 EAGNFICQALNRKTSSKVAQATCKL 325
+ G FIC ALNR+T+SKV+QA C+L
Sbjct: 295 DTGTFICNALNRRTNSKVSQAACRL 319
>ref|XP_001104722.1| PREDICTED: 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase
(hydroxymethylglutaricaciduria) [Macaca mulatta]
Length = 331
Score = 488 bits (1258), Expect = e-136, Method: Composition-based stats.
Identities = 300/331 (90%), Positives = 302/331 (91%), Gaps = 6/331 (1%)
Query: 1 MAAMRKALPRRLVGLASLRAVSTSS------MGTLPKRVKIVEVGPRDGLQNEKNIVSTP 54
MAAM KALPRRLVGLASLRAVS S GTL RV + V P GL+ NIVSTP
Sbjct: 1 MAAMTKALPRRLVGLASLRAVSAPSRRGGGPAGTLTVRVGSLAVPPEWGLRFLTNIVSTP 60
Query: 55 VKIKLIDMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFE 114
VKIKLIDMLSEAGLSVIE TSFVSPKWVPQM DH EVLKGIQKFPGI YPVL PNLKGFE
Sbjct: 61 VKIKLIDMLSEAGLSVIEATSFVSPKWVPQMADHAEVLKGIQKFPGITYPVLIPNLKGFE 120
Query: 115 AAVAAGAKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGC 174
AAVAAGAKEV IFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSC LGC
Sbjct: 121 AAVAAGAKEVSIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCVLGC 180
Query: 175 PYEGKISPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHC 234
PYEGKISPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVP AALAVHC
Sbjct: 181 PYEGKISPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPPAALAVHC 240
Query: 235 HDTYGQALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGV 294
HDTYGQALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGV
Sbjct: 241 HDTYGQALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGV 300
Query: 295 NLQKLLEAGNFICQALNRKTSSKVAQATCKL 325
NLQKLLEAGNFICQALNRKTSSKVAQATCKL
Sbjct: 301 NLQKLLEAGNFICQALNRKTSSKVAQATCKL 331
>ref|NP_061909.2| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-like 1 isoform a
[Homo sapiens]
sp|Q8TB92|HMGC2_HUMAN Probable 3-hydroxymethyl-3-methylglutaryl-CoA lyase 2
(3-hydroxymethyl-3-methylglutaryl-CoA lyase-like protein
1)
gb|EAX04443.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-like 1, isoform
CRA_b [Homo sapiens]
Length = 370
Score = 488 bits (1258), Expect = e-136, Method: Composition-based stats.
Identities = 216/311 (69%), Positives = 261/311 (83%)
Query: 12 LVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVI 71
L G + TS + LP+ VKIVEVGPRDGLQNEK IV T +KI+ I+ LS+ GLSVI
Sbjct: 57 LAGTVACIHWETSQLSGLPEFVKIVEVGPRDGLQNEKVIVPTDIKIEFINRLSQTGLSVI 116
Query: 72 ETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAAS 131
E TSFVS +WVPQM DHTEV+KGI ++PG+ YPVLTPNL+GF AVAAGA E+ +FGAAS
Sbjct: 117 EVTSFVSSRWVPQMADHTEVMKGIHQYPGVRYPVLTPNLQGFHHAVAAGATEISVFGAAS 176
Query: 132 ELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKK 191
E F+KKNINCSIEES +F+ ++K+A+ NI RGYVSCALGCPYEG I+P KV EV+K+
Sbjct: 177 ESFSKKNINCSIEESMGKFEEVVKSARHMNIPARGYVSCALGCPYEGSITPQKVTEVSKR 236
Query: 192 FYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQM 251
Y MGCYEISLGDTIGVGTPG MK ML +VM+E+P ALAVHCHDTYGQALAN L ALQM
Sbjct: 237 LYGMGCYEISLGDTIGVGTPGSMKRMLESVMKEIPPGALAVHCHDTYGQALANILTALQM 296
Query: 252 GVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALN 311
G++VVDS+V+GLGGCPYA+GASGN+ATEDL+YML GLG++TGVNL K++EAG+FIC+A+N
Sbjct: 297 GINVVDSAVSGLGGCPYAKGASGNVATEDLIYMLNGLGLNTGVNLYKVMEAGDFICKAVN 356
Query: 312 RKTSSKVAQAT 322
+ T+SKVAQA+
Sbjct: 357 KTTNSKVAQAS 367
>ref|XP_538973.2| PREDICTED: similar to 3-hydroxymethyl-3-methylglutaryl-Coenzyme A
lyase-like 1 [Canis familiaris]
Length = 343
Score = 487 bits (1254), Expect = e-136, Method: Composition-based stats.
Identities = 215/303 (70%), Positives = 260/303 (85%)
Query: 20 AVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSP 79
A TS + LP+ VKIVEVGPRDGLQNEK IV T +KI+ I+ LS+ GLSVIE TSFVS
Sbjct: 35 AQETSQLSGLPEYVKIVEVGPRDGLQNEKVIVPTDIKIEFINQLSQTGLSVIEVTSFVSS 94
Query: 80 KWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNI 139
KWVPQM DHTEV+KGI ++PG+ YPVLTPNL+GF AVAAGA E+ +FGAASE F+K+NI
Sbjct: 95 KWVPQMADHTEVMKGIHQYPGVRYPVLTPNLQGFHRAVAAGATEISVFGAASESFSKRNI 154
Query: 140 NCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYE 199
NCSIEES ++F+ ++K+A+ NI RGYVSCALGCPYEG I+P KV EV+KK Y MGCYE
Sbjct: 155 NCSIEESMEKFEEVVKSARHMNIPARGYVSCALGCPYEGNITPQKVTEVSKKLYGMGCYE 214
Query: 200 ISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSS 259
ISLGDT GVGTPG MK ML +VM+E+P +ALAVHCHDTYGQALAN L ALQMG++VVDS+
Sbjct: 215 ISLGDTTGVGTPGSMKRMLESVMKEIPSSALAVHCHDTYGQALANILTALQMGINVVDSA 274
Query: 260 VAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVA 319
V+GLGGCPYA+GASGN+ATEDL+YML GLG++TGVNL K++EAG+FIC+A+N+ T+SKVA
Sbjct: 275 VSGLGGCPYAKGASGNVATEDLIYMLNGLGLNTGVNLYKVMEAGDFICKAVNKTTNSKVA 334
Query: 320 QAT 322
QA+
Sbjct: 335 QAS 337
>ref|XP_001363832.1| PREDICTED: similar to alpha-2-macroglobulin receptor [Monodelphis
domestica]
Length = 327
Score = 486 bits (1252), Expect = e-136, Method: Composition-based stats.
Identities = 254/322 (78%), Positives = 285/322 (88%), Gaps = 1/322 (0%)
Query: 5 RKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLS 64
R P RL G +SLRA+S+SS+ PK+VKIVEVGPRDGLQNEK+I+ T +KIKLIDMLS
Sbjct: 6 RTFPPLRLAGTSSLRAISSSSLDAFPKQVKIVEVGPRDGLQNEKHILPTQMKIKLIDMLS 65
Query: 65 EAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEV 124
AGL VIE TSFVSPKWVPQM DH EVL+GI+KFPGI+YPVLTPNL+GF+AAVAAGAKEV
Sbjct: 66 AAGLPVIEATSFVSPKWVPQMADHAEVLQGIEKFPGISYPVLTPNLRGFQAAVAAGAKEV 125
Query: 125 VIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAK 184
IFGAASELF+KKNINCSIEES+QRF+ +L A+ ANI VRGYVSC LGCPYEGK+SPAK
Sbjct: 126 AIFGAASELFSKKNINCSIEESYQRFEEVLTEARCANIPVRGYVSCVLGCPYEGKVSPAK 185
Query: 185 VAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALAN 244
VAEV KK YSMGC+EISLGDTIGVGTP MK+MLSAVM+E+P++ALAVHCHDTYGQALAN
Sbjct: 186 VAEVAKKLYSMGCFEISLGDTIGVGTPLGMKNMLSAVMKEMPVSALAVHCHDTYGQALAN 245
Query: 245 TLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGN 304
LMALQMGVSVVDSSVAGLGGCPY+ GASGN+ATEDL+YML GLGI TGVNLQKL +AG
Sbjct: 246 ILMALQMGVSVVDSSVAGLGGCPYSPGASGNVATEDLLYMLNGLGIDTGVNLQKLTDAGK 305
Query: 305 FICQALNRKTSSKVAQA-TCKL 325
FIC+ALNRK SSKVA A + KL
Sbjct: 306 FICKALNRKNSSKVATAISHKL 327
>ref|NP_957509.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase
(hydroxymethylglutaricaciduria) [Danio rerio]
gb|AAH46023.1| Zgc:56248 [Danio rerio]
Length = 340
Score = 485 bits (1249), Expect = e-135, Method: Composition-based stats.
Identities = 236/321 (73%), Positives = 274/321 (85%)
Query: 5 RKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLS 64
R L L +VS ++ LP+RVKIVEVGPRDGLQNEK IV T VKI+LIDMLS
Sbjct: 20 RPVLHCAASALIRSVSVSAAASQALPERVKIVEVGPRDGLQNEKTIVPTEVKIRLIDMLS 79
Query: 65 EAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEV 124
EAGL VIE TSFVSPKWVPQM D EV++G+ K PG+NYPVLTPNLKGF+AAV AGAKEV
Sbjct: 80 EAGLPVIEATSFVSPKWVPQMADQEEVMRGLHKKPGVNYPVLTPNLKGFQAAVKAGAKEV 139
Query: 125 VIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAK 184
IFGAASELF+KKNINCS+EES RF+ ++ AA+ +SVRGYVSC LGCPYEGK+SP+K
Sbjct: 140 AIFGAASELFSKKNINCSVEESLVRFEEVMTAAKQEGVSVRGYVSCVLGCPYEGKVSPSK 199
Query: 185 VAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALAN 244
VAEV K+ YSMGCYE+SLGDTIGVGTPG M +ML+AV +E+P+ ALAVHCHDTYGQALAN
Sbjct: 200 VAEVAKRLYSMGCYEVSLGDTIGVGTPGGMTEMLNAVKKELPVEALAVHCHDTYGQALAN 259
Query: 245 TLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGN 304
L+ALQ GVSVVDSSVAGLGGCPYAQGASGN+ATED+VYML GLGIHTGV+L +LL+AG+
Sbjct: 260 ILVALQNGVSVVDSSVAGLGGCPYAQGASGNVATEDVVYMLHGLGIHTGVDLPRLLDAGS 319
Query: 305 FICQALNRKTSSKVAQATCKL 325
FIC ++NR+T+SKVAQA+CKL
Sbjct: 320 FICHSINRRTNSKVAQASCKL 340
>ref|XP_001499476.1| PREDICTED: similar to 3-hydroxymethyl-3-methylglutaryl-Coenzyme A
lyase-like 1 [Equus caballus]
Length = 435
Score = 485 bits (1249), Expect = e-135, Method: Composition-based stats.
Identities = 215/305 (70%), Positives = 259/305 (84%)
Query: 20 AVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSP 79
A +S LP+ VKIVEVGPRDGLQNEK IV T +KI+ I+ LS+ GLSVIE TSFVS
Sbjct: 123 AQESSQFSGLPEYVKIVEVGPRDGLQNEKVIVPTDIKIEFINQLSQTGLSVIEVTSFVSS 182
Query: 80 KWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNI 139
+WVPQM DHTEV+KGI + PG+ YPVLTPNL+GF AVAAGA E+ +FGAASE F+KKNI
Sbjct: 183 RWVPQMADHTEVMKGIHQHPGVRYPVLTPNLQGFHRAVAAGATEISVFGAASESFSKKNI 242
Query: 140 NCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYE 199
NCSIEES ++F+ ++K+A+ NI RGYVSCALGCPYEG I+ KV EV+K+ Y MGCYE
Sbjct: 243 NCSIEESMEKFEEVVKSARHMNIPARGYVSCALGCPYEGGITTQKVTEVSKRLYGMGCYE 302
Query: 200 ISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSS 259
ISLGDTIGVGTPG M+ ML +VM+E+P +ALAVHCHDTYGQALAN L ALQMG++VVDS+
Sbjct: 303 ISLGDTIGVGTPGSMRRMLESVMKEIPSSALAVHCHDTYGQALANILTALQMGINVVDSA 362
Query: 260 VAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVA 319
VAGLGGCPYA+GASGN+ATEDL+YML GLG+HTGVNL K++EAG+FIC+A+N+ T+SKVA
Sbjct: 363 VAGLGGCPYAKGASGNVATEDLIYMLHGLGLHTGVNLYKVMEAGDFICKAVNKSTNSKVA 422
Query: 320 QATCK 324
QA+ K
Sbjct: 423 QASFK 427
>ref|NP_001035865.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-like 1 isoform b
[Homo sapiens]
gb|AAH24194.2| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-like 1 [Homo
sapiens]
gb|EAX04444.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-like 1, isoform
CRA_c [Homo sapiens]
Length = 340
Score = 482 bits (1242), Expect = e-134, Method: Composition-based stats.
Identities = 215/303 (70%), Positives = 259/303 (85%)
Query: 20 AVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSP 79
A TS + LP+ VKIVEVGPRDGLQNEK IV T +KI+ I+ LS+ GLSVIE TSFVS
Sbjct: 35 AQETSQLSGLPEFVKIVEVGPRDGLQNEKVIVPTDIKIEFINRLSQTGLSVIEVTSFVSS 94
Query: 80 KWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNI 139
+WVPQM DHTEV+KGI ++PG+ YPVLTPNL+GF AVAAGA E+ +FGAASE F+KKNI
Sbjct: 95 RWVPQMADHTEVMKGIHQYPGVRYPVLTPNLQGFHHAVAAGATEISVFGAASESFSKKNI 154
Query: 140 NCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYE 199
NCSIEES +F+ ++K+A+ NI RGYVSCALGCPYEG I+P KV EV+K+ Y MGCYE
Sbjct: 155 NCSIEESMGKFEEVVKSARHMNIPARGYVSCALGCPYEGSITPQKVTEVSKRLYGMGCYE 214
Query: 200 ISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSS 259
ISLGDTIGVGTPG MK ML +VM+E+P ALAVHCHDTYGQALAN L ALQMG++VVDS+
Sbjct: 215 ISLGDTIGVGTPGSMKRMLESVMKEIPPGALAVHCHDTYGQALANILTALQMGINVVDSA 274
Query: 260 VAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVA 319
V+GLGGCPYA+GASGN+ATEDL+YML GLG++TGVNL K++EAG+FIC+A+N+ T+SKVA
Sbjct: 275 VSGLGGCPYAKGASGNVATEDLIYMLNGLGLNTGVNLYKVMEAGDFICKAVNKTTNSKVA 334
Query: 320 QAT 322
QA+
Sbjct: 335 QAS 337
>ref|XP_001105003.1| PREDICTED: similar to 3-hydroxymethyl-3-methylglutaryl-Coenzyme A
lyase-like 1 [Macaca mulatta]
Length = 444
Score = 480 bits (1237), Expect = e-134, Method: Composition-based stats.
Identities = 218/311 (70%), Positives = 264/311 (84%)
Query: 12 LVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVI 71
L G + TS + LP+ VKIVEVGPRDGLQNEK IV T +KI+ I+ LS+ GLSVI
Sbjct: 131 LAGSVASIHWETSQLSGLPEFVKIVEVGPRDGLQNEKVIVPTDIKIEFINRLSQTGLSVI 190
Query: 72 ETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAAS 131
E TSFVS +WVPQM DHTEV+KGI ++PG++YPVLTPNL+GF AVAAGA E+ +FGAAS
Sbjct: 191 EVTSFVSSRWVPQMADHTEVMKGIHQYPGVHYPVLTPNLQGFHRAVAAGATEISVFGAAS 250
Query: 132 ELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKK 191
E F+KKNINCSIEES +F+ ++K+A+ NI RGYVSCALGCPYEG I+P KV EV+K+
Sbjct: 251 ESFSKKNINCSIEESMGKFEEVVKSARHMNIPARGYVSCALGCPYEGIITPQKVTEVSKR 310
Query: 192 FYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQM 251
YSMGCYEISLGDTIGVGTPG MK ML +VM+E+PL ALAVHCHDTYGQALAN L ALQM
Sbjct: 311 LYSMGCYEISLGDTIGVGTPGSMKRMLESVMKEIPLGALAVHCHDTYGQALANILTALQM 370
Query: 252 GVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALN 311
G++VVDS+V+GLGGCPYA+GASGN+ATEDL+YML GLG++TGVNL K++EAG+FIC+A+N
Sbjct: 371 GINVVDSAVSGLGGCPYAKGASGNVATEDLIYMLNGLGLNTGVNLYKVMEAGDFICKAVN 430
Query: 312 RKTSSKVAQAT 322
+ T+SKVAQA+
Sbjct: 431 KTTNSKVAQAS 441
>gb|EDL77774.1| similar to 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-like 1
(predicted), isoform CRA_a [Rattus norvegicus]
Length = 343
Score = 480 bits (1237), Expect = e-134, Method: Composition-based stats.
Identities = 210/305 (68%), Positives = 256/305 (83%)
Query: 20 AVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSP 79
A S + LP+ VKIVEVGPRDGLQNEK IV T +KI+ I+ LS+ GLSVIE TSFVS
Sbjct: 35 AQEASQLSGLPEYVKIVEVGPRDGLQNEKVIVPTDIKIEFINQLSQTGLSVIEVTSFVSS 94
Query: 80 KWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNI 139
+WVPQM DH EV+ GI ++PG+ YPVL PNL+G + AVAAGA E+ +FGAASE F+KKNI
Sbjct: 95 RWVPQMADHAEVMGGIHQYPGVRYPVLVPNLQGLQHAVAAGATEIAVFGAASESFSKKNI 154
Query: 140 NCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYE 199
NCSIEES RF+ ++ +A+ NI VRGYVSCALGCPYEG I P KV EV+K+ YSMGCYE
Sbjct: 155 NCSIEESMGRFEQVISSARHMNIPVRGYVSCALGCPYEGSIMPQKVTEVSKRLYSMGCYE 214
Query: 200 ISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSS 259
ISLGDT+GVGTPG MK ML +VM+E+P ALAVHCHDTYGQALAN L ALQMG++VVDS+
Sbjct: 215 ISLGDTVGVGTPGSMKTMLESVMKEIPPGALAVHCHDTYGQALANILTALQMGINVVDSA 274
Query: 260 VAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVA 319
V+GLGGCPYA+GASGN+ATEDL+YML G+G++TGV+L K++EAG+FIC+A+N+ T+SKVA
Sbjct: 275 VSGLGGCPYAKGASGNVATEDLIYMLNGMGLNTGVDLHKVMEAGDFICKAVNKTTNSKVA 334
Query: 320 QATCK 324
QA+ K
Sbjct: 335 QASFK 339
>emb|CAG09900.1| unnamed protein product [Tetraodon nigroviridis]
Length = 337
Score = 480 bits (1237), Expect = e-134, Method: Composition-based stats.
Identities = 229/310 (73%), Positives = 265/310 (85%)
Query: 16 ASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTS 75
A A + TLP++VKIVEVGPRDGLQNEK IV + KI LID+LS +GL VIE TS
Sbjct: 28 AGKSAAGLRACQTLPEKVKIVEVGPRDGLQNEKTIVPSETKIHLIDLLSASGLPVIEATS 87
Query: 76 FVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFT 135
FVSPKWVPQM D EV+KGI + PG++YPVLTPNLKGF+AAV AGA EV IFGAASELF+
Sbjct: 88 FVSPKWVPQMADQVEVMKGISRRPGVSYPVLTPNLKGFQAAVQAGASEVAIFGAASELFS 147
Query: 136 KKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSM 195
KKNINCS++ES QRFD ++KAA+ A + VRGYVSC LGCPYEGK+ P KVA V K+ Y+M
Sbjct: 148 KKNINCSVDESLQRFDEVMKAAKEAGVPVRGYVSCVLGCPYEGKVEPVKVAHVAKRLYAM 207
Query: 196 GCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSV 255
GCYEISLGDTIGVGTPG M+DML V +EVP++ALAVHCHDTYGQALAN L+ALQMGVSV
Sbjct: 208 GCYEISLGDTIGVGTPGSMRDMLEVVSREVPVSALAVHCHDTYGQALANILVALQMGVSV 267
Query: 256 VDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTS 315
VDSSVAGLGGCPYAQGASGN+ATED+VYML GLGI TGV+L K+++AG FIC++LNR+T+
Sbjct: 268 VDSSVAGLGGCPYAQGASGNVATEDVVYMLHGLGIQTGVDLSKVMDAGAFICRSLNRRTN 327
Query: 316 SKVAQATCKL 325
SKVAQATCKL
Sbjct: 328 SKVAQATCKL 337
>ref|NP_776092.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-like 1 [Mus
musculus]
sp|Q8JZS7|HMGC2_MOUSE Probable 3-hydroxymethyl-3-methylglutaryl-CoA lyase 2
(3-hydroxymethyl-3-methylglutaryl-CoA lyase-like protein
1)
gb|AAH37381.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-like 1 [Mus
musculus]
dbj|BAE24772.1| unnamed protein product [Mus musculus]
gb|EDL26339.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-like 1, isoform
CRA_c [Mus musculus]
Length = 343
Score = 479 bits (1234), Expect = e-133, Method: Composition-based stats.
Identities = 211/303 (69%), Positives = 258/303 (85%)
Query: 20 AVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSP 79
A S + LP+ VKIVEVGPRDGLQNEK IV T +KI+LI+ LS+ GLSVIE TSFVS
Sbjct: 35 AQEASQLPGLPEYVKIVEVGPRDGLQNEKVIVPTDIKIELINQLSQTGLSVIEVTSFVSS 94
Query: 80 KWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNI 139
+WVPQM DH EV++GI+++PG+ YPVLTPNL+GF+ AVAAGA E+ +FGAASE F+KKNI
Sbjct: 95 RWVPQMADHAEVMRGIRQYPGVRYPVLTPNLQGFQHAVAAGATEIAVFGAASESFSKKNI 154
Query: 140 NCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYE 199
NCSIEES RF ++ +A+ +I VRGYVSCALGCPYEG I+P KV EV+K+ Y MGCYE
Sbjct: 155 NCSIEESMGRFQEVISSARHMDIPVRGYVSCALGCPYEGSITPQKVTEVSKRLYGMGCYE 214
Query: 200 ISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSS 259
ISLGDTIGVGTPG MK ML +VM+E+P ALAVHCHDTYGQALAN L ALQMG++VVDS+
Sbjct: 215 ISLGDTIGVGTPGSMKMMLESVMKEIPPGALAVHCHDTYGQALANILTALQMGINVVDSA 274
Query: 260 VAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVA 319
V+GLGGCPYA+GASGN+ATEDL+YML G+G++TGV+L K++EAG FIC+A+N+ T+SKVA
Sbjct: 275 VSGLGGCPYAKGASGNVATEDLIYMLNGMGLNTGVDLYKVMEAGEFICKAVNKTTNSKVA 334
Query: 320 QAT 322
QA+
Sbjct: 335 QAS 337
>ref|NP_001103870.1| hypothetical protein LOC571388 [Danio rerio]
sp|A8WG57|HMGC2_DANRE Probable 3-hydroxymethyl-3-methylglutaryl-CoA lyase 2
(3-hydroxymethyl-3-methylglutaryl-CoA lyase-like protein
1)
gb|AAI54588.1| LOC571388 protein [Danio rerio]
Length = 335
Score = 477 bits (1228), Expect = e-133, Method: Composition-based stats.
Identities = 211/300 (70%), Positives = 254/300 (84%)
Query: 24 SSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVP 83
S + LP VKIVEVGPRDGLQNEK IV T VKI+LID+LS+ GL VIE TSFVS KWV
Sbjct: 34 SELPKLPVYVKIVEVGPRDGLQNEKEIVPTEVKIQLIDLLSQTGLPVIEATSFVSSKWVA 93
Query: 84 QMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNINCSI 143
QM DHT VLKGI++ P + YPVLTPN++GF+AAVAAGA EV +FG+ASE F++KNINCSI
Sbjct: 94 QMADHTAVLKGIKRSPDVRYPVLTPNIQGFQAAVAAGANEVAVFGSASETFSRKNINCSI 153
Query: 144 EESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLG 203
EES QRF+ ++ AA+ I VRGYVSCALGCPYEG++ P++V +V K+ + +GCYE+SLG
Sbjct: 154 EESLQRFEQVVSAAKQEGIPVRGYVSCALGCPYEGQVKPSQVTKVAKRLFELGCYEVSLG 213
Query: 204 DTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGL 263
DTIGVGT G M +MLS V+ EVP ALAVHCHDTYGQAL N L+ALQMGVSVVD+SVAGL
Sbjct: 214 DTIGVGTAGSMAEMLSDVLTEVPAGALAVHCHDTYGQALPNILIALQMGVSVVDASVAGL 273
Query: 264 GGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQATC 323
GGCP+A+GASGN++TEDL+YML GLGI TGV+L K++EAG+FIC+ALNRKT+SKV+QAT
Sbjct: 274 GGCPFAKGASGNVSTEDLLYMLHGLGIETGVDLLKVMEAGDFICKALNRKTNSKVSQATR 333
>ref|XP_001196745.1| PREDICTED: similar to MGC82338 protein [Strongylocentrotus
purpuratus]
ref|XP_001177727.1| PREDICTED: similar to MGC82338 protein [Strongylocentrotus
purpuratus]
Length = 313
Score = 476 bits (1226), Expect = e-132, Method: Composition-based stats.
Identities = 201/313 (64%), Positives = 251/313 (80%), Gaps = 2/313 (0%)
Query: 15 LASLRAVSTSSMGT--LPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIE 72
+ R V++ + +P+ VKIVEVGPRDGLQNEK +V T KI+LI+ LS+ GL VIE
Sbjct: 1 MVGRRGVASLAGRDAQIPRSVKIVEVGPRDGLQNEKAMVPTETKIELINRLSDTGLKVIE 60
Query: 73 TTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASE 132
TSFVSPKW+PQMGDHT+V+ GI + G++YPVLTPNL+GF++A+ AGA+EV IFGAASE
Sbjct: 61 ATSFVSPKWIPQMGDHTDVMNGITRRGGVSYPVLTPNLQGFKSALEAGAEEVAIFGAASE 120
Query: 133 LFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKF 192
F+KKNINCSI+ES +RF ++L+AA+ AN+ VRGYVSC LGCPYEG + P VA+V K
Sbjct: 121 TFSKKNINCSIDESVERFSSVLEAAREANVKVRGYVSCVLGCPYEGAVQPEAVAKVANKM 180
Query: 193 YSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMG 252
+ MGCYEISLGDTIGVGTPG M+ +L V++ +P +AVHCHDTYGQALAN L ALQMG
Sbjct: 181 FDMGCYEISLGDTIGVGTPGQMQVLLETVLETIPAKHIAVHCHDTYGQALANILAALQMG 240
Query: 253 VSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNR 312
V+VVDSSVAGLGGCPYA+GASGN+ATED+VYML GLGI TG++L+K++ G FI + L R
Sbjct: 241 VTVVDSSVAGLGGCPYAKGASGNVATEDVVYMLNGLGIETGIDLEKIVSVGQFISRELGR 300
Query: 313 KTSSKVAQATCKL 325
+ +SKV A KL
Sbjct: 301 QNTSKVGNAMSKL 313
>gb|AAL89669.1|AF411956_10 hydroxymethylglutaryl-CoA lyase [Takifugu rubripes]
Length = 325
Score = 475 bits (1224), Expect = e-132, Method: Composition-based stats.
Identities = 233/326 (71%), Positives = 270/326 (82%), Gaps = 2/326 (0%)
Query: 1 MAAM-RKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKL 59
MAA+ + + R + A + S L + VKIVEVGPRDGLQNEK IV KI L
Sbjct: 1 MAALAMRVINRSTLNAAMCQHYLAFSSAKL-QSVKIVEVGPRDGLQNEKTIVPLETKIHL 59
Query: 60 IDMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAA 119
IDMLS +GL VIE TSFVSPKWVPQM D EV+KGI + PG++YPVLTPNLKGF+AAV+A
Sbjct: 60 IDMLSASGLPVIEATSFVSPKWVPQMADQVEVMKGISRKPGVSYPVLTPNLKGFQAAVSA 119
Query: 120 GAKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGK 179
GA EV IFGAASELF+KKNINCS++ES QRFD ++KAA+ A + VRGYVSC LGCPYEGK
Sbjct: 120 GASEVAIFGAASELFSKKNINCSVDESLQRFDEVMKAAKEAGVPVRGYVSCVLGCPYEGK 179
Query: 180 ISPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYG 239
+ PAKVA V K+ YSMGCYEISLGDTIGVGTPG M +ML V +EVP++ALAVHCHDTYG
Sbjct: 180 VEPAKVAHVAKRLYSMGCYEISLGDTIGVGTPGSMCEMLKVVSREVPVSALAVHCHDTYG 239
Query: 240 QALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKL 299
QALAN L+ALQMGVSVVDSSVAGLGGCPYAQGASGN+ATED+VYML GLGI TGV+L K+
Sbjct: 240 QALANILVALQMGVSVVDSSVAGLGGCPYAQGASGNVATEDVVYMLHGLGIQTGVDLSKV 299
Query: 300 LEAGNFICQALNRKTSSKVAQATCKL 325
++AG FIC++LNRK++SKVAQATCKL
Sbjct: 300 MDAGAFICRSLNRKSNSKVAQATCKL 325
>ref|XP_419903.1| PREDICTED: similar to 3-hydroxymethyl-3-methylglutaryl-Coenzyme A
lyase-like 1 [Gallus gallus]
Length = 420
Score = 475 bits (1223), Expect = e-132, Method: Composition-based stats.
Identities = 220/299 (73%), Positives = 259/299 (86%)
Query: 24 SSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVP 83
S LP+ VKIVEVGPRDGLQNEK IV T KI+LI+ LS+ GL IE TSFVS KWVP
Sbjct: 115 SQASGLPEYVKIVEVGPRDGLQNEKVIVPTDTKIELINRLSKTGLPAIEVTSFVSSKWVP 174
Query: 84 QMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNINCSI 143
QM DH EV++GI++ PG+ YPVLTPNLKGF +A+AAGA EV +FGAASE F+K NINCSI
Sbjct: 175 QMADHKEVMRGIERHPGVQYPVLTPNLKGFHSAIAAGATEVSVFGAASESFSKMNINCSI 234
Query: 144 EESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLG 203
EES ++F+ + K+A++ NI VRGYVSCALGCPYEG I+PAKVAEV+K+ YSMGCYEISLG
Sbjct: 235 EESIEKFEEVAKSARNMNIPVRGYVSCALGCPYEGDITPAKVAEVSKRLYSMGCYEISLG 294
Query: 204 DTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGL 263
DTIGVGTPG MK ML AVM+E+PL+ALAVHCHDTYGQALAN L A+QMGV+VVDSSVAGL
Sbjct: 295 DTIGVGTPGSMKRMLEAVMKEIPLSALAVHCHDTYGQALANILTAIQMGVAVVDSSVAGL 354
Query: 264 GGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQAT 322
GGCPYA+GA+GN+ATED++YML GLGI+TGVNL ++EAGNFIC ALN+KT+SKVAQA+
Sbjct: 355 GGCPYAKGATGNVATEDVIYMLNGLGINTGVNLYTVMEAGNFICTALNKKTNSKVAQAS 413
>gb|ABA95738.2| Hydroxymethylglutaryl-CoA lyase, mitochondrial precursor, putative,
expressed [Oryza sativa (japonica cultivar-group)]
gb|EAY82185.1| hypothetical protein OsI_036144 [Oryza sativa (indica
cultivar-group)]
gb|EAZ17365.1| hypothetical protein OsJ_031574 [Oryza sativa (japonica
cultivar-group)]
Length = 387
Score = 473 bits (1219), Expect = e-132, Method: Composition-based stats.
Identities = 189/307 (61%), Positives = 240/307 (78%)
Query: 19 RAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVS 78
RA+ + LP+ VKIVEVGPRDGLQNEKN V T VKI+LI L +GLSV+E TSFVS
Sbjct: 79 RALPRKVLWDLPRFVKIVEVGPRDGLQNEKNTVPTSVKIELIHKLVASGLSVVEATSFVS 138
Query: 79 PKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKN 138
PKWVPQ+ D +V++GI+ P + +PVLTPNL+GFEAAVAAGAKEV +F +ASE F+K N
Sbjct: 139 PKWVPQLADAKDVVEGIKHVPDVRFPVLTPNLRGFEAAVAAGAKEVAVFASASESFSKSN 198
Query: 139 INCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCY 198
+NC+I+ES R+ ++ +A+ I +RGYVSC +GCP EG I P+KVA V K+ Y MGC
Sbjct: 199 LNCTIKESLVRYHDVVTSAKKHGIRIRGYVSCVVGCPVEGTIHPSKVAYVAKELYDMGCS 258
Query: 199 EISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDS 258
EISLGDTIGVGTPG + ML AVM VP+ +AVH HDTYGQALAN L++LQ+G+++VDS
Sbjct: 259 EISLGDTIGVGTPGSVLAMLEAVMSFVPVDKIAVHFHDTYGQALANILVSLQLGINIVDS 318
Query: 259 SVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKV 318
SV+GLGGCPYA+GA+GN+ATED+VYML GLGI T V+L KL++AG++I + L R++ SK
Sbjct: 319 SVSGLGGCPYAKGATGNVATEDVVYMLHGLGIETNVDLNKLMDAGDYISKHLGRQSGSKT 378
Query: 319 AQATCKL 325
A KL
Sbjct: 379 TTALRKL 385
>ref|XP_615612.3| PREDICTED: similar to 3-hydroxymethyl-3-methylglutaryl-Coenzyme A
lyase-like 1 isoform 2 [Bos taurus]
Length = 370
Score = 471 bits (1214), Expect = e-131, Method: Composition-based stats.
Identities = 210/315 (66%), Positives = 261/315 (82%), Gaps = 4/315 (1%)
Query: 8 LPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAG 67
LPR +V + ++ + P+ VKIVEVGPRDGLQNEK IV T +KI+ I+ LS+ G
Sbjct: 57 LPRVVVTV----HWESAQLSGFPEYVKIVEVGPRDGLQNEKVIVPTDIKIEFINQLSQTG 112
Query: 68 LSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIF 127
LSVIE TSFVS +W+PQM DHTEV+KGI ++PGI YPVLTPNL+GF AVAAGA EV +F
Sbjct: 113 LSVIEVTSFVSSRWIPQMADHTEVMKGIHQYPGIRYPVLTPNLQGFHRAVAAGATEVSVF 172
Query: 128 GAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAE 187
GAASE F+KKNINCSIEES ++F+ ++K+A+ NI RGYVSCALGCPYEG I+ KV E
Sbjct: 173 GAASESFSKKNINCSIEESMKKFEEVVKSARHMNIPARGYVSCALGCPYEGNITLQKVTE 232
Query: 188 VTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLM 247
V+K+ Y MGCYEISLGDTIGVGTPG MK ML +VM+E+P ALAVHCHDTYGQA + L+
Sbjct: 233 VSKRLYGMGCYEISLGDTIGVGTPGSMKKMLESVMKEIPPRALAVHCHDTYGQASSGILL 292
Query: 248 ALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFIC 307
+QMG++VVDS+V+GLGGCPYA+GASGN+ATEDL+YML GLG++TGVNL K++EAG+FIC
Sbjct: 293 KIQMGINVVDSAVSGLGGCPYAKGASGNVATEDLIYMLNGLGVNTGVNLYKVMEAGDFIC 352
Query: 308 QALNRKTSSKVAQAT 322
+A+N+ T+SKVAQA+
Sbjct: 353 KAVNKTTNSKVAQAS 367
>ref|NP_001065695.1| Os11g0137200 [Oryza sativa (japonica cultivar-group)]
gb|ABA91354.1| Hydroxymethylglutaryl-CoA lyase, mitochondrial precursor, putative,
expressed [Oryza sativa (japonica cultivar-group)]
dbj|BAF27540.1| Os11g0137200 [Oryza sativa (japonica cultivar-group)]
gb|EAY79856.1| hypothetical protein OsI_033815 [Oryza sativa (indica
cultivar-group)]
gb|EAZ17357.1| hypothetical protein OsJ_031566 [Oryza sativa (japonica
cultivar-group)]
Length = 387
Score = 471 bits (1214), Expect = e-131, Method: Composition-based stats.
Identities = 187/307 (60%), Positives = 239/307 (77%)
Query: 19 RAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVS 78
RA+ + LP+ VKIVEVGPRDGLQNEK+ V VKI+LI L +GLSV+E TSFVS
Sbjct: 79 RALPRKVLWELPRFVKIVEVGPRDGLQNEKSTVPASVKIELIHKLVASGLSVVEATSFVS 138
Query: 79 PKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKN 138
PKWVPQ+ D +VL+GI+ P + +PVLTPNL+GFEAA+AAGAKEV +F +ASE F+K N
Sbjct: 139 PKWVPQLADAKDVLQGIRHVPDVRFPVLTPNLRGFEAALAAGAKEVAVFASASESFSKSN 198
Query: 139 INCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCY 198
+NC+I+ES R+ ++ +A+ + +RGYVSC +GCP EG I P+KVA V K+ Y MGC
Sbjct: 199 LNCTIKESLVRYRDVVTSAKKHGMRIRGYVSCVVGCPVEGTIHPSKVAYVAKELYDMGCS 258
Query: 199 EISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDS 258
EISLGDTIGVGTPG + ML AVM VP+ LAVH HDTYGQALAN L++LQ+G+++VDS
Sbjct: 259 EISLGDTIGVGTPGSILAMLEAVMSFVPVDKLAVHFHDTYGQALANILVSLQLGINIVDS 318
Query: 259 SVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKV 318
SV+GLGGCPYA+GA+GN+ATED+VYML GLGI T V+L KL++AG++I + L R++ SK
Sbjct: 319 SVSGLGGCPYAKGATGNVATEDVVYMLHGLGIETNVDLNKLMDAGDYISKHLGRQSGSKT 378
Query: 319 AQATCKL 325
A KL
Sbjct: 379 TTALRKL 385
>sp|P35915|HMGCL_CHICK Hydroxymethylglutaryl-CoA lyase (HMG-CoA lyase) (HL)
(3-hydroxy-3-methylglutarate-CoA lyase)
Length = 298
Score = 471 bits (1213), Expect = e-131, Method: Composition-based stats.
Identities = 236/297 (79%), Positives = 269/297 (90%)
Query: 29 LPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQMGDH 88
P+RVK+VEVGPRDGLQNEK++V TPVKI+LIDMLSE GL VIE TSFVSP+WVPQM DH
Sbjct: 2 FPQRVKVVEVGPRDGLQNEKSVVPTPVKIRLIDMLSETGLPVIEATSFVSPRWVPQMADH 61
Query: 89 TEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNINCSIEESFQ 148
EV++GI K PG++YPVLTPNLKGF+AAVAAGAKEV IFGAASELFTKKNINCSIEES +
Sbjct: 62 AEVMQGINKLPGVSYPVLTPNLKGFQAAVAAGAKEVSIFGAASELFTKKNINCSIEESLE 121
Query: 149 RFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLGDTIGV 208
RF ++ AA++A+I VRGYVSC LGCPYEG IS AKVAEV+KK YSMGCYEISLGD IG+
Sbjct: 122 RFSEVMNAARAASIPVRGYVSCVLGCPYEGNISAAKVAEVSKKMYSMGCYEISLGDRIGI 181
Query: 209 GTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGGCPY 268
GTPG MK+ML+AVM+EVP+ ALAVHCHDTYGQALAN L+ALQMGVSVVD+SVAGLGGCPY
Sbjct: 182 GTPGSMKEMLAAVMKEVPVGALAVHCHDTYGQALANILVALQMGVSVVDASVAGLGGCPY 241
Query: 269 AQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQATCKL 325
AQGASGN+ATEDLVYML GLGIHTGV+LQKL++ G FIC ALNR+T+SKV+QA C+L
Sbjct: 242 AQGASGNVATEDLVYMLNGLGIHTGVDLQKLMDTGTFICNALNRRTNSKVSQAACRL 298
>ref|XP_001371535.1| PREDICTED: similar to 3-hydroxymethyl-3-methylglutaryl-Coenzyme A
lyase-like 1 [Monodelphis domestica]
Length = 338
Score = 469 bits (1207), Expect = e-130, Method: Composition-based stats.
Identities = 214/303 (70%), Positives = 262/303 (86%), Gaps = 2/303 (0%)
Query: 20 AVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSP 79
A + + P+ VKIVEVGPRDGLQNEK IV T +KI+ I+ LS+ GLSVIE TSFVS
Sbjct: 35 AQEVTQLSGFPEYVKIVEVGPRDGLQNEKVIVPTDIKIEFINQLSKTGLSVIEVTSFVSS 94
Query: 80 KWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNI 139
KWVPQM D TEV+KGI ++PG+ YPVLT L+GF A+AAGA EV +FGAASE F+KKNI
Sbjct: 95 KWVPQMADQTEVMKGIYQYPGVRYPVLT--LQGFHHAIAAGATEVSVFGAASESFSKKNI 152
Query: 140 NCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYE 199
NCSIEES +RF+A++K+A+ N+ VRGYVSCALGCPYEG+I+P KVAEV+K+ YSMGCYE
Sbjct: 153 NCSIEESMERFEAVVKSARHMNVPVRGYVSCALGCPYEGQIAPEKVAEVSKQLYSMGCYE 212
Query: 200 ISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSS 259
ISLGDTIGVGTPG MK ML +VM+E+P++ALAVHCHDTYGQALAN L ALQMG++VVDS+
Sbjct: 213 ISLGDTIGVGTPGSMKRMLESVMKEIPISALAVHCHDTYGQALANILTALQMGINVVDSA 272
Query: 260 VAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVA 319
V+GLGGCPYA+GASGN+ATEDL+YML G+G++TGVNL K++EAGNFIC+A+N+ T+SKVA
Sbjct: 273 VSGLGGCPYAKGASGNVATEDLIYMLNGIGLNTGVNLYKVMEAGNFICRAINKTTNSKVA 332
Query: 320 QAT 322
QA+
Sbjct: 333 QAS 335
>ref|XP_001252308.1| PREDICTED: similar to 3-hydroxymethyl-3-methylglutaryl-Coenzyme A
lyase-like 1 isoform 1 [Bos taurus]
Length = 340
Score = 467 bits (1204), Expect = e-130, Method: Composition-based stats.
Identities = 207/303 (68%), Positives = 256/303 (84%)
Query: 20 AVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSP 79
A ++ + P+ VKIVEVGPRDGLQNEK IV T +KI+ I+ LS+ GLSVIE TSFVS
Sbjct: 35 AQESAQLSGFPEYVKIVEVGPRDGLQNEKVIVPTDIKIEFINQLSQTGLSVIEVTSFVSS 94
Query: 80 KWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNI 139
+W+PQM DHTEV+KGI ++PGI YPVLTPNL+GF AVAAGA EV +FGAASE F+KKNI
Sbjct: 95 RWIPQMADHTEVMKGIHQYPGIRYPVLTPNLQGFHRAVAAGATEVSVFGAASESFSKKNI 154
Query: 140 NCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYE 199
NCSIEES ++F+ ++K+A+ NI RGYVSCALGCPYEG I+ KV EV+K+ Y MGCYE
Sbjct: 155 NCSIEESMKKFEEVVKSARHMNIPARGYVSCALGCPYEGNITLQKVTEVSKRLYGMGCYE 214
Query: 200 ISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSS 259
ISLGDTIGVGTPG MK ML +VM+E+P ALAVHCHDTYGQA + L+ +QMG++VVDS+
Sbjct: 215 ISLGDTIGVGTPGSMKKMLESVMKEIPPRALAVHCHDTYGQASSGILLKIQMGINVVDSA 274
Query: 260 VAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVA 319
V+GLGGCPYA+GASGN+ATEDL+YML GLG++TGVNL K++EAG+FIC+A+N+ T+SKVA
Sbjct: 275 VSGLGGCPYAKGASGNVATEDLIYMLNGLGVNTGVNLYKVMEAGDFICKAVNKTTNSKVA 334
Query: 320 QAT 322
QA+
Sbjct: 335 QAS 337
>ref|XP_345954.2| PREDICTED: similar to 3-hydroxymethyl-3-methylglutaryl-Coenzyme A
lyase-like 1 [Rattus norvegicus]
ref|XP_001058331.1| PREDICTED: similar to 3-hydroxymethyl-3-methylglutaryl-Coenzyme A
lyase-like 1 [Rattus norvegicus]
Length = 433
Score = 467 bits (1203), Expect = e-130, Method: Composition-based stats.
Identities = 210/305 (68%), Positives = 256/305 (83%)
Query: 20 AVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSP 79
A S + LP+ VKIVEVGPRDGLQNEK IV T +KI+ I+ LS+ GLSVIE TSFVS
Sbjct: 125 AQEASQLSGLPEYVKIVEVGPRDGLQNEKVIVPTDIKIEFINQLSQTGLSVIEVTSFVSS 184
Query: 80 KWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNI 139
+WVPQM DH EV+ GI ++PG+ YPVL PNL+G + AVAAGA E+ +FGAASE F+KKNI
Sbjct: 185 RWVPQMADHAEVMGGIHQYPGVRYPVLVPNLQGLQHAVAAGATEIAVFGAASESFSKKNI 244
Query: 140 NCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYE 199
NCSIEES RF+ ++ +A+ NI VRGYVSCALGCPYEG I P KV EV+K+ YSMGCYE
Sbjct: 245 NCSIEESMGRFEQVISSARHMNIPVRGYVSCALGCPYEGSIMPQKVTEVSKRLYSMGCYE 304
Query: 200 ISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSS 259
ISLGDT+GVGTPG MK ML +VM+E+P ALAVHCHDTYGQALAN L ALQMG++VVDS+
Sbjct: 305 ISLGDTVGVGTPGSMKTMLESVMKEIPPGALAVHCHDTYGQALANILTALQMGINVVDSA 364
Query: 260 VAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVA 319
V+GLGGCPYA+GASGN+ATEDL+YML G+G++TGV+L K++EAG+FIC+A+N+ T+SKVA
Sbjct: 365 VSGLGGCPYAKGASGNVATEDLIYMLNGMGLNTGVDLHKVMEAGDFICKAVNKTTNSKVA 424
Query: 320 QATCK 324
QA+ K
Sbjct: 425 QASFK 429
>ref|XP_001166145.1| PREDICTED: similar to 3-hydroxymethyl-3-methylglutaryl-Coenzyme A
lyase (hydroxymethylglutaricaciduria) isoform 1 [Pan
troglodytes]
Length = 293
Score = 466 bits (1201), Expect = e-130, Method: Composition-based stats.
Identities = 290/325 (89%), Positives = 292/325 (89%), Gaps = 32/325 (9%)
Query: 1 MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKL+
Sbjct: 1 MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLV 60
Query: 61 DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAG 120
DMLSEAGLSVIETTSFVSPKWVPQ+ AG
Sbjct: 61 DMLSEAGLSVIETTSFVSPKWVPQVA--------------------------------AG 88
Query: 121 AKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
AKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI
Sbjct: 89 AKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 148
Query: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ
Sbjct: 149 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 208
Query: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL
Sbjct: 209 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 268
Query: 301 EAGNFICQALNRKTSSKVAQATCKL 325
EAGNFICQALNRKTSSKVAQATCKL
Sbjct: 269 EAGNFICQALNRKTSSKVAQATCKL 293
>ref|ZP_02912623.1| pyruvate carboxyltransferase [Geobacillus sp. WCH70]
gb|EDT36389.1| pyruvate carboxyltransferase [Geobacillus sp. WCH70]
Length = 299
Score = 465 bits (1198), Expect = e-129, Method: Composition-based stats.
Identities = 152/295 (51%), Positives = 203/295 (68%)
Query: 26 MGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQM 85
M PK+V I EVGPRDGLQNEK +ST KI I+ LS+ GL+ IE TSFV PKW+PQ+
Sbjct: 1 MSKWPKQVTIKEVGPRDGLQNEKTAISTEDKIAWINQLSKTGLTYIEITSFVHPKWIPQL 60
Query: 86 GDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNINCSIEE 145
D EV I++ PG+ Y L PN KG E A+ A EV +F +ASE +KNIN SIEE
Sbjct: 61 SDALEVATRIERAPGVTYAALVPNQKGLEKALTAQVDEVAVFMSASETHNRKNINKSIEE 120
Query: 146 SFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLGDT 205
+F + +++AA+ +VRGYVS GCPYEG +S +V V+++ + MG E+SLGDT
Sbjct: 121 TFPVLEEVVRAAKQEGKTVRGYVSTVFGCPYEGNVSVEQVIRVSERLFDMGIDELSLGDT 180
Query: 206 IGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGG 265
IGV TP ++++L V++ P LA+H HDT G ALAN L++L+MG++ DSS+ GLGG
Sbjct: 181 IGVATPKQVQELLEIVLKRFPKEKLAMHFHDTRGTALANILISLEMGITTFDSSLGGLGG 240
Query: 266 CPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQ 320
CPYA GASGN+AT+DLVYML G+ I TG+++ +L EA FI + + R SS+ Q
Sbjct: 241 CPYAPGASGNVATDDLVYMLHGMDIATGIDVGRLTEAALFIQEKIGRPLSSRYLQ 295
>dbj|BAE71196.1| putative hydroxymethylglutaryl-CoA lyase [Trifolium pratense]
Length = 433
Score = 464 bits (1195), Expect = e-129, Method: Composition-based stats.
Identities = 195/309 (63%), Positives = 241/309 (77%)
Query: 17 SLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSF 76
++ ++ M +P VKIVEVGPRDGLQNEKN+VST VKI+LI L+ GLSVIE TSF
Sbjct: 118 DMQDMAYKVMKGMPGFVKIVEVGPRDGLQNEKNMVSTDVKIELIHRLASTGLSVIEATSF 177
Query: 77 VSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTK 136
VSPKWVPQ+ D +V+K + GI PVLTPNLKGFEAA+AAGA+EV +F +ASE F+K
Sbjct: 178 VSPKWVPQLADAKDVMKAVHNLGGIRLPVLTPNLKGFEAAIAAGAREVAVFASASESFSK 237
Query: 137 KNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMG 196
NINCSIEES R+ A+ AA++ +I VRGYVSC +GCP EG +SP+KVA V K+ Y MG
Sbjct: 238 SNINCSIEESLARYRAVTSAAKALSIPVRGYVSCVVGCPVEGSVSPSKVAYVAKELYDMG 297
Query: 197 CYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVV 256
C+EISLGDTIGVGTPG + ML AVM VP LAVH HDTYGQ+L+N L++LQMG+S V
Sbjct: 298 CFEISLGDTIGVGTPGTVVPMLLAVMAVVPTEKLAVHFHDTYGQSLSNILVSLQMGISAV 357
Query: 257 DSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSS 316
DSSVAGLGGCPYA+GASGN+ATED+VYML GLG+ T V+++KL+ AG+FI + L R + S
Sbjct: 358 DSSVAGLGGCPYAKGASGNVATEDVVYMLNGLGVKTNVDIEKLMSAGDFIGKHLGRPSGS 417
Query: 317 KVAQATCKL 325
K A A ++
Sbjct: 418 KTAIALSRV 426
>emb|CAO67270.1| unnamed protein product [Vitis vinifera]
Length = 432
Score = 462 bits (1189), Expect = e-128, Method: Composition-based stats.
Identities = 193/308 (62%), Positives = 235/308 (76%)
Query: 18 LRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFV 77
+R ++ +G +PK VKIVEVGPRDGLQNEKNIV T VK++LI L GL V+E TSFV
Sbjct: 118 VRGMANKFLGGIPKFVKIVEVGPRDGLQNEKNIVPTAVKVELIHRLVSCGLPVVEATSFV 177
Query: 78 SPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKK 137
SPKWVPQ+ D +V++ ++ G PVLTPNLKGFEAA+AAGAKEV IF +ASE F+K
Sbjct: 178 SPKWVPQLADAKDVMEAVRNLEGARLPVLTPNLKGFEAAIAAGAKEVAIFASASESFSKS 237
Query: 138 NINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGC 197
NINCSIEES R+ A+ AA+ +I VRGYVSC +GCP EG ISP+KVA V K+ Y MGC
Sbjct: 238 NINCSIEESLTRYRAVALAAKKLSIPVRGYVSCVVGCPVEGAISPSKVAYVAKELYDMGC 297
Query: 198 YEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVD 257
+EISLGDTIGV TPG + ML AVM VP+ LAVH HDTYGQ+L N L++LQMG+S +D
Sbjct: 298 FEISLGDTIGVATPGAIVPMLEAVMAVVPVEKLAVHFHDTYGQSLPNILLSLQMGISTID 357
Query: 258 SSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSK 317
SSVAGLGGCPYA+GASGN+ATED+VYML GLG+ T V+L KL+ G+FI L R + SK
Sbjct: 358 SSVAGLGGCPYAKGASGNVATEDVVYMLNGLGVKTNVDLGKLMLVGDFISNRLGRPSGSK 417
Query: 318 VAQATCKL 325
A A ++
Sbjct: 418 TAIALSRV 425
>ref|NP_001066093.1| Os12g0134000 [Oryza sativa (japonica cultivar-group)]
gb|ABG21875.1| Hydroxymethylglutaryl-CoA lyase, mitochondrial precursor, putative,
expressed [Oryza sativa (japonica cultivar-group)]
dbj|BAF29112.1| Os12g0134000 [Oryza sativa (japonica cultivar-group)]
Length = 377
Score = 462 bits (1189), Expect = e-128, Method: Composition-based stats.
Identities = 187/300 (62%), Positives = 237/300 (79%)
Query: 26 MGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQM 85
+ LP+ VKIVEVGPRDGLQNEKN V T VKI+LI L +GLSV+E TSFVSPKWVPQ+
Sbjct: 76 LWDLPRFVKIVEVGPRDGLQNEKNTVPTSVKIELIHKLVASGLSVVEATSFVSPKWVPQL 135
Query: 86 GDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNINCSIEE 145
D +V++GI+ P + +PVLTPNL+GFEAAVAAGAKEV +F +ASE F+K N+NC+I+E
Sbjct: 136 ADAKDVVEGIKHVPDVRFPVLTPNLRGFEAAVAAGAKEVAVFASASESFSKSNLNCTIKE 195
Query: 146 SFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLGDT 205
S R+ ++ +A+ I +RGYVSC +GCP EG I P+KVA V K+ Y MGC EISLGDT
Sbjct: 196 SLVRYHDVVTSAKKHGIRIRGYVSCVVGCPVEGTIHPSKVAYVAKELYDMGCSEISLGDT 255
Query: 206 IGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGG 265
IGVGTPG + ML AVM VP+ +AVH HDTYGQALAN L++LQ+G+++VDSSV+GLGG
Sbjct: 256 IGVGTPGSVLAMLEAVMSFVPVDKIAVHFHDTYGQALANILVSLQLGINIVDSSVSGLGG 315
Query: 266 CPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQATCKL 325
CPYA+GA+GN+ATED+VYML GLGI T V+L KL++AG++I + L R++ SK A KL
Sbjct: 316 CPYAKGATGNVATEDVVYMLHGLGIETNVDLNKLMDAGDYISKHLGRQSGSKTTTALRKL 375
>gb|AAA92728.1| hydroxymethylglutaryl-CoA lyase
Length = 292
Score = 461 bits (1188), Expect = e-128, Method: Composition-based stats.
Identities = 231/292 (79%), Positives = 264/292 (90%)
Query: 34 KIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLK 93
+ +EVGPRDGLQNEK++V TPVKI+LIDMLSE GL VIE TSFVSP+WVPQM DH EV++
Sbjct: 1 EFLEVGPRDGLQNEKSVVPTPVKIRLIDMLSETGLPVIEATSFVSPRWVPQMADHAEVMQ 60
Query: 94 GIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNINCSIEESFQRFDAI 153
GI K PG++YPVLTPNLKGF+AAVAAGAKEV IFGAASELFTKKNINCSIEES +RF +
Sbjct: 61 GINKLPGVSYPVLTPNLKGFQAAVAAGAKEVSIFGAASELFTKKNINCSIEESLERFSEV 120
Query: 154 LKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGI 213
+ AA++A+I VRGYVSC LGCPYEG IS AKVAEV+KK YSMGCYEISLGD IG+GTPG
Sbjct: 121 MNAARAASIPVRGYVSCVLGCPYEGNISAAKVAEVSKKMYSMGCYEISLGDRIGIGTPGS 180
Query: 214 MKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGGCPYAQGAS 273
MK+ML+AVM+EVP+ ALAVHCHDTYGQALAN L+ALQMGVSVVD+SVAGLGGCPYAQGAS
Sbjct: 181 MKEMLAAVMKEVPVGALAVHCHDTYGQALANILVALQMGVSVVDASVAGLGGCPYAQGAS 240
Query: 274 GNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQATCKL 325
GN+ATEDLVYML GLGIHTGV+LQKL++ G FIC ALNR+T+SKV+QA C+L
Sbjct: 241 GNVATEDLVYMLNGLGIHTGVDLQKLMDTGTFICNALNRRTNSKVSQAACRL 292
>ref|NP_565629.1| hydroxymethylglutaryl-CoA lyase, putative /
3-hydroxy-3-methylglutarate-CoA lyase, putative /
HMG-CoA lyase, putative [Arabidopsis thaliana]
gb|AAG42010.1|AF327420_1 putative hydroxymethylglutaryl-CoA lyase [Arabidopsis thaliana]
gb|AAK15568.1|AF349521_1 putative hydroxymethylglutaryl-CoA lyase [Arabidopsis thaliana]
gb|AAC32247.2| putative hydroxymethylglutaryl-CoA lyase [Arabidopsis thaliana]
Length = 468
Score = 460 bits (1185), Expect = e-128, Method: Composition-based stats.
Identities = 188/297 (63%), Positives = 228/297 (76%)
Query: 28 TLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQMGD 87
+PK VKIVEVGPRDGLQNEKNIV T VK++LI L +GL V+E TSFVSPKWVPQ+ D
Sbjct: 163 GIPKFVKIVEVGPRDGLQNEKNIVPTSVKVELIQRLVSSGLPVVEATSFVSPKWVPQLAD 222
Query: 88 HTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNINCSIEESF 147
+V+ + G PVLTPNLKGF+AAV+AGAKEV IF +ASE F+ NINC+IEES
Sbjct: 223 AKDVMDAVNTLDGARLPVLTPNLKGFQAAVSAGAKEVAIFASASESFSLSNINCTIEESL 282
Query: 148 QRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLGDTIG 207
R+ + AA+ ++ VRGYVSC +GCP EG + P+KVA V K+ Y MGC+EISLGDTIG
Sbjct: 283 LRYRVVATAAKEHSVPVRGYVSCVVGCPVEGPVLPSKVAYVVKELYDMGCFEISLGDTIG 342
Query: 208 VGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGGCP 267
+GTPG + ML AVM VP LAVH HDTYGQALAN L++LQMG+S+VDSS+AGLGGCP
Sbjct: 343 IGTPGSVVPMLEAVMAVVPADKLAVHFHDTYGQALANILVSLQMGISIVDSSIAGLGGCP 402
Query: 268 YAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQATCK 324
YA+GASGN+ATED+VYML GLG+HT V+L KL+ AG+FI + L R SK A A +
Sbjct: 403 YAKGASGNVATEDVVYMLNGLGVHTNVDLGKLIAAGDFISKHLGRPNGSKAAVALNR 459
Searching..................................................done
Results from round 3
Score E
Sequences producing significant alignments: (bits) Value
Sequences used in model and found again:
sp|Q8HXZ6|HMGCL_MACFA Hydroxymethylglutaryl-CoA lyase, mito... 528 e-148
ref|NP_000182.2| 3-hydroxymethyl-3-methylglutaryl-Coenzyme ... 528 e-148
gb|AAA92733.1| hydroxymethylglutaryl-CoA lyase [Homo sapiens] 526 e-147
ref|XP_001166273.1| PREDICTED: 3-hydroxymethyl-3-methylglut... 526 e-147
sp|Q5R9E1|HMGCL_PONPY Hydroxymethylglutaryl-CoA lyase, mito... 524 e-147
dbj|BAE88248.1| unnamed protein product [Macaca fascicularis] 523 e-147
ref|NP_077362.1| 3-hydroxy-3-methylglutaryl-Coenzyme A lyas... 523 e-146
ref|NP_032280.2| 3-hydroxy-3-methylglutaryl-Coenzyme A lyas... 521 e-146
dbj|BAE26056.1| unnamed protein product [Mus musculus] 520 e-146
ref|NP_001068600.1| 3-hydroxymethyl-3-methylglutaryl-Coenzy... 520 e-146
ref|XP_001504254.1| PREDICTED: similar to interleukin 13 re... 519 e-145
gb|AAB03107.1| 3-hydroxy-3-methylglutaryl-CoA lyase 516 e-145
sp|P38060|HMGCL_MOUSE Hydroxymethylglutaryl-CoA lyase, mito... 514 e-144
ref|XP_535360.2| PREDICTED: similar to Hydroxymethylglutary... 506 e-141
ref|XP_513200.2| PREDICTED: similar to 3-hydroxymethyl-3-me... 497 e-139
gb|AAB19099.1| hydroxymethylglutaryl-CoA lyase 497 e-139
ref|NP_001085152.1| hypothetical protein LOC432233 [Xenopus... 495 e-138
emb|CAI23161.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A... 493 e-138
ref|NP_061909.2| 3-hydroxymethyl-3-methylglutaryl-Coenzyme ... 492 e-137
ref|XP_001166216.1| PREDICTED: similar to 3-hydroxymethyl-3... 492 e-137
ref|XP_538973.2| PREDICTED: similar to 3-hydroxymethyl-3-me... 491 e-137
pdb|2CW6|A Chain A, Crystal Structure Of Human Hmg-Coa Lyas... 491 e-137
ref|NP_957509.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme ... 490 e-137
ref|XP_001363832.1| PREDICTED: similar to alpha-2-macroglob... 489 e-137
ref|XP_417834.1| PREDICTED: similar to Hydroxymethylglutary... 489 e-136
ref|XP_001499476.1| PREDICTED: similar to 3-hydroxymethyl-3... 487 e-136
emb|CAG09900.1| unnamed protein product [Tetraodon nigrovir... 486 e-135
ref|NP_001035865.1| 3-hydroxymethyl-3-methylglutaryl-Coenzy... 486 e-135
gb|EDL77774.1| similar to 3-hydroxymethyl-3-methylglutaryl-... 485 e-135
ref|XP_001196745.1| PREDICTED: similar to MGC82338 protein ... 484 e-135
ref|XP_001105003.1| PREDICTED: similar to 3-hydroxymethyl-3... 484 e-135
gb|AAL89669.1|AF411956_10 hydroxymethylglutaryl-CoA lyase [... 484 e-135
ref|NP_776092.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme ... 483 e-135
ref|NP_001103870.1| hypothetical protein LOC571388 [Danio r... 482 e-134
gb|ABA95738.2| Hydroxymethylglutaryl-CoA lyase, mitochondri... 481 e-134
ref|XP_419903.1| PREDICTED: similar to 3-hydroxymethyl-3-me... 481 e-134
ref|NP_001065695.1| Os11g0137200 [Oryza sativa (japonica cu... 479 e-133
ref|XP_001104722.1| PREDICTED: 3-hydroxymethyl-3-methylglut... 478 e-133
ref|ZP_02912623.1| pyruvate carboxyltransferase [Geobacillu... 476 e-133
ref|XP_615612.3| PREDICTED: similar to 3-hydroxymethyl-3-me... 476 e-132
dbj|BAE71196.1| putative hydroxymethylglutaryl-CoA lyase [T... 474 e-132
ref|XP_001371535.1| PREDICTED: similar to 3-hydroxymethyl-3... 474 e-132
sp|P35915|HMGCL_CHICK Hydroxymethylglutaryl-CoA lyase (HMG-... 473 e-131
ref|XP_345954.2| PREDICTED: similar to 3-hydroxymethyl-3-me... 472 e-131
ref|XP_001252308.1| PREDICTED: similar to 3-hydroxymethyl-3... 471 e-131
ref|NP_001066093.1| Os12g0134000 [Oryza sativa (japonica cu... 471 e-131
emb|CAO67270.1| unnamed protein product [Vitis vinifera] 470 e-131
ref|YP_001502656.1| pyruvate carboxyltransferase [Shewanell... 467 e-130
ref|NP_565629.1| hydroxymethylglutaryl-CoA lyase, putative ... 467 e-130
ref|NP_609089.1| CG10399 CG10399-PA [Drosophila melanogaste... 466 e-130
ref|XP_001767580.1| predicted protein [Physcomitrella paten... 466 e-129
ref|XP_001355781.1| GA10298-PA [Drosophila pseudoobscura] >... 465 e-129
ref|NP_850087.1| hydroxymethylglutaryl-CoA lyase, putative ... 464 e-129
gb|AAY55779.1| IP10508p [Drosophila melanogaster] 464 e-129
gb|AAA92728.1| hydroxymethylglutaryl-CoA lyase 463 e-129
ref|YP_268341.1| hydroxymethylglutaryl-CoA lyase [Colwellia... 462 e-128
ref|YP_001675115.1| pyruvate carboxyltransferase [Shewanell... 461 e-128
gb|EAZ11369.1| hypothetical protein OsJ_001194 [Oryza sativ... 461 e-128
ref|XP_638884.1| hydroxymethylglutaryl-CoA lyase [Dictyoste... 461 e-128
ref|YP_283315.1| Pyruvate carboxyltransferase [Dechloromona... 460 e-128
ref|ZP_01894930.1| 3-hydroxymethylglutaryl-CoA or malyl-CoA... 460 e-128
gb|EAY73450.1| hypothetical protein OsI_001297 [Oryza sativ... 460 e-128
ref|XP_001638492.1| predicted protein [Nematostella vectens... 460 e-128
ref|XP_314824.4| AGAP008717-PA [Anopheles gambiae str. PEST... 459 e-127
ref|YP_751410.1| pyruvate carboxyltransferase [Shewanella f... 459 e-127
ref|ZP_01617610.1| hydroxymethylglutaryl-CoA lyase [marine ... 459 e-127
ref|ZP_01165306.1| Pyruvate carboxyltransferase [Oceanospir... 459 e-127
ref|XP_001166145.1| PREDICTED: similar to 3-hydroxymethyl-3... 459 e-127
ref|YP_001187522.1| hydroxymethylglutaryl-CoA lyase [Pseudo... 459 e-127
ref|YP_001173695.1| hydroxymethylglutaryl-CoA lyase [Pseudo... 457 e-127
ref|YP_001250583.1| hydroxymethylglutaryl-CoA lyase [Legion... 457 e-127
ref|ZP_01043050.1| Hydroxymethylglutaryl-CoA lyase [Idiomar... 457 e-127
ref|YP_349383.1| hydroxymethylglutaryl-CoA lyase [Pseudomon... 457 e-127
ref|YP_959392.1| pyruvate carboxyltransferase [Marinobacter... 457 e-127
ref|YP_261034.1| hydroxymethylglutaryl-CoA lyase [Pseudomon... 455 e-126
ref|YP_001267557.1| hydroxymethylglutaryl-CoA lyase [Pseudo... 455 e-126
ref|YP_001473193.1| pyruvate carboxyltransferase [Shewanell... 455 e-126
ref|ZP_01076043.1| 3-hydroxymethylglutaryl-CoA or malyl-CoA... 455 e-126
gb|EEJ81164.1| hydroxymethylglutaryl-CoA lyase [Kangiella k... 455 e-126
ref|YP_001555403.1| pyruvate carboxyltransferase [Shewanell... 455 e-126
ref|YP_001094699.1| pyruvate carboxyltransferase [Shewanell... 455 e-126
ref|YP_001125565.1| hydroxymethylglutaryl-CoA lyase [Geobac... 455 e-126
ref|ZP_01840459.1| pyruvate carboxyltransferase [Shewanella... 455 e-126
ref|YP_001051186.1| pyruvate carboxyltransferase [Shewanell... 455 e-126
ref|ZP_02157638.1| hydroxymethylglutaryl-CoA lyase [Shewane... 454 e-126
ref|ZP_01260765.1| hydroxymethylglutaryl-CoA lyase [Vibrio ... 454 e-126
ref|YP_095856.1| hydroxymethylglutaryl-CoA lyase [Legionell... 454 e-126
ref|NP_745677.1| hydroxymethylglutaryl-CoA lyase [Pseudomon... 454 e-126
ref|NP_001042696.1| Os01g0269000 [Oryza sativa (japonica cu... 453 e-126
ref|YP_001367047.1| pyruvate carboxyltransferase [Shewanell... 453 e-126
ref|NP_800125.1| hydroxymethylglutaryl-CoA lyase [Vibrio pa... 453 e-126
ref|XP_001606475.1| PREDICTED: similar to hydroxymethylglut... 453 e-126
ref|YP_001348638.1| hydroxymethylglutaryl-CoA lyase [Pseudo... 453 e-125
emb|CAO18214.1| unnamed protein product [Vitis vinifera] 452 e-125
ref|YP_127132.1| hypothetical protein lpl1794 [Legionella p... 452 e-125
ref|YP_001668619.1| pyruvate carboxyltransferase [Pseudomon... 452 e-125
ref|YP_001748815.1| pyruvate carboxyltransferase [Pseudomon... 452 e-125
gb|ABN08537.1| Pyruvate carboxyltransferase [Medicago trunc... 452 e-125
dbj|BAD81168.1| putative hydroxymethylglutaryl-CoA lyase [O... 452 e-125
ref|YP_927235.1| pyruvate carboxyltransferase [Shewanella a... 452 e-125
pdb|2FTP|A Chain A, Crystal Structure Of Hydroxymethylgluta... 451 e-125
ref|NP_250701.1| hydroxymethylglutaryl-CoA lyase [Pseudomon... 451 e-125
ref|ZP_00969554.1| COG0119: Isopropylmalate/homocitrate/cit... 450 e-125
ref|YP_001424886.1| hydroxymethylglutaryl-CoA lyase [Coxiel... 450 e-125
gb|AAT51198.1| PA2011 [synthetic construct] 450 e-125
ref|NP_792548.1| hydroxymethylglutaryl-CoA lyase [Pseudomon... 450 e-125
ref|ZP_01985852.1| hydroxymethylglutaryl-CoA lyase [Vibrio ... 450 e-125
ref|YP_235548.1| hydroxymethylglutaryl-CoA lyase [Pseudomon... 450 e-125
ref|ZP_01989357.1| hydroxymethylglutaryl-CoA lyase [Vibrio ... 450 e-125
ref|YP_147454.1| hydroxymethylglutaryl-CoA lyase [Geobacill... 450 e-125
ref|YP_662491.1| pyruvate carboxyltransferase [Pseudoaltero... 449 e-125
ref|YP_001761592.1| pyruvate carboxyltransferase [Shewanell... 449 e-125
ref|XP_001025212.1| HMGL-like family protein [Tetrahymena t... 449 e-124
ref|NP_819552.1| hydroxymethylglutaryl-CoA lyase [Coxiella ... 449 e-124
ref|ZP_01946497.2| hydroxymethylglutaryl-CoA lyase [Coxiell... 449 e-124
ref|YP_001596451.1| hydroxymethylglutaryl-CoA lyase [Coxiel... 449 e-124
ref|ZP_01475929.1| hypothetical protein VEx2w_02001435 [Vib... 449 e-124
ref|NP_800639.1| putative hydroxymethylglutaryl-CoA lyase [... 448 e-124
ref|ZP_00974724.1| COG0119: Isopropylmalate/homocitrate/cit... 448 e-124
ref|ZP_01109008.1| hydroxymethylglutaryl-CoA lyase [Alterom... 448 e-124
ref|YP_274820.1| hydroxymethylglutaryl-CoA lyase [Pseudomon... 447 e-124
ref|YP_525054.1| pyruvate carboxyltransferase [Rhodoferax f... 447 e-124
ref|ZP_00975701.1| COG0119: Isopropylmalate/homocitrate/cit... 447 e-124
ref|ZP_01219333.1| putative hydroxymethylglutaryl-CoA lyase... 447 e-124
ref|ZP_02194290.1| hydroxymethylglutaryl-CoA lyase [Vibrio ... 446 e-123
ref|ZP_00056425.1| COG0119: Isopropylmalate/homocitrate/cit... 446 e-123
ref|XP_973049.1| PREDICTED: similar to CG10399-PA [Triboliu... 446 e-123
ref|YP_159665.1| 3-hydroxymethylglutaryl-CoA or malyl-CoA l... 446 e-123
ref|YP_987942.1| pyruvate carboxyltransferase [Acidovorax s... 445 e-123
ref|ZP_01738810.1| 3-hydroxymethylglutaryl-CoA or malyl-CoA... 445 e-123
ref|YP_738441.1| pyruvate carboxyltransferase [Shewanella s... 445 e-123
ref|ZP_01899775.1| Hydroxymethylglutaryl-CoA lyase [Moritel... 445 e-123
ref|ZP_01477180.1| hypothetical protein VEx2w_02000016 [Vib... 445 e-123
ref|XP_001843753.1| hydroxymethylglutaryl-CoA lyase [Culex ... 445 e-123
ref|YP_550945.1| pyruvate carboxyltransferase [Polaromonas ... 444 e-123
ref|YP_980720.1| pyruvate carboxyltransferase [Polaromonas ... 444 e-123
ref|YP_001351814.1| hydroxymethylglutaryl-CoA lyase [Janthi... 444 e-123
ref|YP_001447608.1| hydroxymethylglutaryl-CoA lyase [Vibrio... 444 e-123
ref|YP_001856404.1| pyruvate carboxyltransferase [Burkholde... 444 e-123
ref|XP_001654565.1| hydroxymethylglutaryl-coa lyase [Aedes ... 444 e-123
ref|YP_079304.1| putative hydroxymethylglutaryl-CoA lyase [... 444 e-123
ref|ZP_01990241.1| hydroxymethylglutaryl-CoA lyase [Vibrio ... 444 e-123
ref|YP_001894089.1| pyruvate carboxyltransferase [Burkholde... 443 e-123
ref|YP_001633348.1| hydroxymethylglutaryl-CoA lyase [Bordet... 443 e-123
ref|YP_784735.1| hydroxymethylglutaryl-CoA lyase [Bordetell... 443 e-122
ref|NP_717501.1| hydroxymethylglutaryl-CoA lyase [Shewanell... 442 e-122
ref|ZP_01102127.1| hydroxymethylglutaryl-CoA lyase [gamma p... 442 e-122
ref|ZP_00417242.1| HMG-CoA lyase-like [Azotobacter vineland... 442 e-122
ref|NP_389705.1| hydroxymethylglutaryl-CoA lyase [Bacillus ... 442 e-122
ref|YP_608548.1| hydroxymethylglutaryl-CoA lyase [Pseudomon... 442 e-122
ref|ZP_01522450.1| pyruvate carboxyltransferase [Comamonas ... 442 e-122
ref|XP_001748375.1| predicted protein [Monosiga brevicollis... 442 e-122
ref|YP_972663.1| pyruvate carboxyltransferase [Acidovorax a... 441 e-122
ref|YP_132791.1| putative hydroxymethylglutaryl-CoA lyase [... 441 e-122
ref|YP_563253.1| Hydroxymethylglutaryl-CoA lyase [Shewanell... 441 e-122
ref|YP_734454.1| pyruvate carboxyltransferase [Shewanella s... 440 e-122
ref|YP_001696645.1| Hydroxymethylglutaryl-CoA lyase [Lysini... 440 e-122
ref|YP_343884.1| Pyruvate carboxyltransferase [Nitrosococcu... 440 e-122
ref|ZP_01260030.1| putative hydroxymethylglutaryl-CoA lyase... 440 e-122
ref|ZP_01723191.1| hydroxymethylglutaryl-CoA lyase [Bacillu... 440 e-122
ref|ZP_01707035.1| pyruvate carboxyltransferase [Shewanella... 440 e-122
ref|YP_001566977.1| pyruvate carboxyltransferase [Delftia a... 439 e-121
ref|YP_869307.1| pyruvate carboxyltransferase [Shewanella s... 439 e-121
ref|NP_937105.1| putative hydroxymethylglutaryl-CoA lyase [... 439 e-121
ref|YP_556781.1| hydroxymethylglutaryl-CoA lyase [Burkholde... 439 e-121
ref|ZP_02882797.1| pyruvate carboxyltransferase [Burkholder... 438 e-121
ref|YP_963688.1| pyruvate carboxyltransferase [Shewanella s... 438 e-121
ref|YP_001714131.1| putative Hydroxymethylglutaryl-CoA lyas... 438 e-121
ref|YP_002773338.1| hydroxymethylglutaryl-CoA lyase [Brevib... 437 e-121
ref|YP_294379.1| hydroxymethylglutaryl-CoA lyase [Ralstonia... 437 e-121
ref|YP_001846066.1| Isopropylmalate/homocitrate/citramalate... 437 e-121
ref|YP_106960.1| hydroxymethylglutaryl-CoA lyase [Burkholde... 435 e-120
ref|ZP_02354193.1| hydroxymethylglutaryl-CoA lyase [Burkhol... 435 e-120
ref|YP_435092.1| Isopropylmalate/homocitrate/citramalate sy... 435 e-120
ref|ZP_02006287.1| pyruvate carboxyltransferase [Ralstonia ... 435 e-120
ref|ZP_02462060.1| hydroxymethylglutaryl-CoA lyase [Burkhol... 435 e-120
ref|NP_882598.1| hydroxymethylglutaryl-CoA lyase [Bordetell... 435 e-120
ref|NP_879404.1| hydroxymethylglutaryl-CoA lyase [Bordetell... 434 e-120
gb|AAF32339.1|AF218939_7 hydroxymethylglutaryl-CoA lyase [B... 434 e-120
ref|YP_582762.1| hydroxymethylglutaryl-CoA lyase [Ralstonia... 434 e-120
pdb|1YDO|A Chain A, Crystal Structure Of The Bacillis Subti... 434 e-120
ref|YP_001809562.1| pyruvate carboxyltransferase [Burkholde... 433 e-120
ref|YP_001183239.1| pyruvate carboxyltransferase [Shewanell... 433 e-120
ref|ZP_02911146.1| pyruvate carboxyltransferase [Burkholder... 433 e-119
ref|YP_774897.1| hydroxymethylglutaryl-CoA lyase [Burkholde... 432 e-119
ref|YP_001791147.1| pyruvate carboxyltransferase [Leptothri... 432 e-119
ref|YP_155267.1| Hydroxymethylglutaryl-CoA lyase [Idiomarin... 432 e-119
ref|ZP_00987697.1| COG0119: Isopropylmalate/homocitrate/cit... 432 e-119
ref|YP_001897709.1| pyruvate carboxyltransferase [Ralstonia... 432 e-119
ref|XP_001771511.1| predicted protein [Physcomitrella paten... 432 e-119
ref|ZP_02893054.1| pyruvate carboxyltransferase [Burkholder... 432 e-119
ref|ZP_02842380.1| pyruvate carboxyltransferase [Thauera sp... 432 e-119
ref|YP_001645201.1| pyruvate carboxyltransferase [Bacillus ... 432 e-119
ref|YP_420036.1| Isopropylmalate/homocitrate/citramalate sy... 431 e-119
ref|YP_339966.1| Hydroxymethylglutaryl-CoA lyase (HMG-CoA l... 431 e-119
ref|YP_001375099.1| pyruvate carboxyltransferase [Bacillus ... 431 e-119
ref|YP_001581136.1| pyruvate carboxyltransferase [Burkholde... 431 e-119
ref|ZP_01696476.1| pyruvate carboxyltransferase [Bacillus c... 431 e-119
ref|ZP_00980803.1| COG0119: Isopropylmalate/homocitrate/cit... 431 e-119
ref|YP_001766260.1| pyruvate carboxyltransferase [Burkholde... 430 e-119
ref|XP_001426433.1| hypothetical protein GSPATT00029666001 ... 430 e-119
ref|YP_724706.1| hydroxymethylglutaryl-CoA lyase [Ralstonia... 430 e-119
ref|ZP_02523119.1| hydroxymethylglutaryl-CoA lyase [Bacillu... 430 e-119
ref|NP_978859.1| hydroxymethylglutaryl-CoA lyase [Bacillus ... 430 e-119
ref|ZP_00946303.1| Hydroxymethylglutaryl-CoA lyase [Ralston... 430 e-119
ref|ZP_01614249.1| Hydroxymethylglutaryl-CoA lyase (HMG-CoA... 430 e-119
ref|YP_001524912.1| hydroxymethylglutaryl-CoA lyase [Azorhi... 430 e-119
ref|NP_844918.1| hydroxymethylglutaryl-CoA lyase [Bacillus ... 430 e-119
ref|NP_001040133.1| hydroxymethylglutaryl-CoA lyase [Bombyx... 429 e-118
ref|ZP_02256685.1| hydroxymethylglutaryl-CoA lyase [Bacillu... 429 e-118
ref|YP_440871.1| hydroxymethylglutaryl-CoA lyase [Burkholde... 429 e-118
ref|ZP_02876504.1| 3-hydroxy-3-methylglutarate-CoA lyase [B... 429 e-118
ref|YP_036656.1| hydroxymethylglutaryl-CoA lyase [Bacillus ... 429 e-118
ref|YP_370547.1| hydroxymethylglutaryl-CoA lyase [Burkholde... 429 e-118
ref|ZP_02600521.1| hydroxymethylglutaryl-CoA lyase [Bacillu... 429 e-118
ref|NP_832245.1| hydroxymethylglutaryl-CoA lyase [Bacillus ... 429 e-118
ref|YP_631935.1| hydroxymethylglutaryl-CoA lyase [Myxococcu... 429 e-118
ref|YP_001280953.1| pyruvate carboxyltransferase [Psychroba... 429 e-118
ref|YP_083878.1| hydroxymethylglutaryl-CoA lyase [Bacillus ... 429 e-118
ref|ZP_01644741.1| pyruvate carboxyltransferase [Stenotroph... 429 e-118
ref|YP_263616.1| probable hydroxymethylglutaryl-coenzyme A ... 428 e-118
emb|CAM76025.1| Pyruvate carboxyltransferase [Magnetospiril... 428 e-118
ref|ZP_01869471.1| putative hydroxymethylglutaryl-CoA lyase... 428 e-118
ref|ZP_02372445.1| hydroxymethylglutaryl-CoA lyase [Burkhol... 428 e-118
ref|ZP_02582523.1| hydroxymethylglutaryl-CoA lyase [Bacillu... 428 e-118
ref|YP_622219.1| hydroxymethylglutaryl-CoA lyase [Burkholde... 427 e-118
ref|ZP_03824456.1| hydroxymethylglutaryl-CoA lyase (3-hydro... 427 e-118
ref|ZP_01133898.1| Hydroxymethylglutaryl-CoA lyase (HMG-CoA... 427 e-118
ref|ZP_01766709.1| hydroxymethylglutaryl-CoA lyase [Burkhol... 427 e-118
ref|ZP_02377633.1| hydroxymethylglutaryl-CoA lyase [Burkhol... 427 e-118
ref|YP_001795524.1| HYDROXYMETHYLGLUTARYL-COA LYASE PROTEIN... 427 e-118
ref|ZP_00240861.1| hydroxymethylglutaryl-CoA lyase [Bacillu... 426 e-118
ref|XP_001770817.1| predicted protein [Physcomitrella paten... 426 e-117
ref|YP_579611.1| pyruvate carboxyltransferase [Psychrobacte... 426 e-117
ref|ZP_01112572.1| hydroxymethylglutaryl-CoA lyase [Reineke... 426 e-117
gb|EDP48120.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A ... 425 e-117
ref|YP_001120874.1| hydroxymethylglutaryl-CoA lyase [Burkho... 425 e-117
ref|YP_934568.1| hydroxymethylglutaryl-CoA lyase [Azoarcus ... 425 e-117
ref|ZP_03881357.1| hydroxymethylglutaryl-CoA lyase [Haliang... 425 e-117
ref|YP_001614964.1| Hydroxymethylglutaryl-CoA lyase [Sorang... 425 e-117
ref|NP_357129.2| hydroxymethylglutaryl-CoA lyase [Agrobacte... 424 e-117
ref|XP_501226.1| hypothetical protein [Yarrowia lipolytica]... 424 e-117
ref|ZP_01224251.1| hydroxymethylglutaryl-CoA lyase [marine ... 424 e-117
ref|NP_642177.1| hydroxymethylglutaryl-CoA lyase [Xanthomon... 424 e-117
ref|ZP_01308647.1| hydroxymethylglutaryl-CoA lyase [Oceanob... 424 e-117
ref|YP_001903524.1| Hydroxymethylglutaryl-CoA lyase [Xantho... 424 e-117
ref|XP_746760.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme ... 423 e-116
ref|YP_001022542.1| hydroxymethylglutaryl-CoA lyase [Methyl... 423 e-116
ref|YP_001416756.1| pyruvate carboxyltransferase [Xanthobac... 423 e-116
ref|YP_725743.1| Hydroxymethylglutaryl-CoA lyase [Ralstonia... 422 e-116
ref|YP_386231.1| Pyruvate carboxyltransferase [Geobacter me... 422 e-116
ref|ZP_01549388.1| hydroxymethylglutaryl-CoA lyase [Stappia... 422 e-116
ref|YP_995316.1| pyruvate carboxyltransferase [Verminephrob... 422 e-116
ref|ZP_01913861.1| hydroxymethylglutaryl-CoA lyase [Limnoba... 421 e-116
ref|ZP_01736989.1| Pyruvate carboxyltransferase [Marinobact... 421 e-116
ref|XP_001122226.1| PREDICTED: similar to CG10399-PA [Apis ... 420 e-116
ref|YP_295676.1| hydroxymethylglutaryl-CoA lyase [Ralstonia... 420 e-116
ref|YP_001421429.1| YngG [Bacillus amyloliquefaciens FZB42]... 420 e-116
ref|NP_518382.1| hydroxymethylglutaryl-CoA lyase [Ralstonia... 420 e-116
ref|ZP_01722603.1| hydroxymethylglutaryl-CoA lyase [Bacillu... 419 e-115
ref|YP_002796051.1| Hydroxymethylglutaryl-CoA lyase [Lariba... 419 e-115
ref|NP_826453.1| hydroxymethylglutaryl-CoA lyase [Streptomy... 418 e-115
gb|EEJ95321.1| hydroxymethylglutaryl-CoA lyase [Thermomonos... 418 e-115
ref|YP_001108593.1| hydroxymethylglutaryl-CoA lyase [Saccha... 417 e-115
ref|YP_001890635.1| pyruvate carboxyltransferase [Burkholde... 417 e-115
ref|ZP_01159378.1| putative hydroxymethylglutaryl-CoA lyase... 417 e-115
ref|ZP_01233364.1| putative hydroxymethylglutaryl-CoA lyase... 417 e-115
ref|XP_663886.1| hypothetical protein AN6282.2 [Aspergillus... 417 e-115
ref|XP_001667667.1| Hypothetical protein CBG22170 [Caenorha... 417 e-115
ref|YP_347047.1| Pyruvate carboxyltransferase [Pseudomonas ... 417 e-115
ref|YP_001240021.1| hydroxymethylglutaryl-CoA lyase [Bradyr... 416 e-114
ref|YP_001487014.1| hydroxymethylglutaryl-CoA lyase [Bacill... 415 e-114
ref|ZP_03817872.1| hydroxymethylglutaryl-CoA lyase [Actinos... 414 e-114
ref|YP_001340336.1| pyruvate carboxyltransferase [Marinomon... 414 e-114
ref|NP_637197.1| hydroxymethylglutaryl-CoA lyase [Xanthomon... 414 e-114
ref|YP_001205681.1| hydroxymethylglutaryl-CoA lyase (HMG-Co... 414 e-114
ref|YP_532647.1| pyruvate carboxyltransferase [Rhodopseudom... 414 e-114
ref|ZP_02882110.1| pyruvate carboxyltransferase [Burkholder... 413 e-113
ref|XP_001262809.1| 3-hydroxymethyl-3-methylglutaryl-Coenzy... 413 e-113
ref|NP_970304.1| hydroxymethylglutaryl-CoA lyase [Bdellovib... 412 e-113
ref|YP_486545.1| Pyruvate carboxyltransferase [Rhodopseudom... 412 e-113
ref|ZP_03862034.1| hydroxymethylglutaryl-CoA lyase [Kribbel... 412 e-113
ref|NP_692264.1| hydroxymethylglutaryl-CoA lyase [Oceanobac... 412 e-113
ref|XP_963242.1| hydroxymethylglutaryl-CoA lyase [Neurospor... 412 e-113
ref|YP_872161.1| hydroxymethylglutaryl-CoA lyase [Acidother... 412 e-113
ref|YP_363628.1| hydroxymethylglutaryl-CoA lyase [Xanthomon... 412 e-113
ref|NP_771062.1| hydroxymethylglutaryl-CoA lyase [Bradyrhiz... 412 e-113
ref|YP_001764959.1| pyruvate carboxyltransferase [Burkholde... 412 e-113
ref|NP_242000.1| hydroxymethylglutaryl-CoA lyase [Bacillus ... 412 e-113
ref|ZP_00417696.1| HMG-CoA lyase-like [Azotobacter vineland... 412 e-113
gb|EEK05215.1| hydroxymethylglutaryl-CoA lyase [Alicyclobac... 412 e-113
ref|ZP_01128907.1| Pyruvate carboxyltransferase [Nitrococcu... 411 e-113
ref|NP_490889.1| Y71G12B.10 [Caenorhabditis elegans] >gi|14... 411 e-113
emb|CAK32536.1| Hydroxymethylglutaryl-CoA lyase [uncultured... 411 e-113
ref|YP_621093.1| pyruvate carboxyltransferase [Burkholderia... 411 e-113
ref|ZP_00982678.1| COG0119: Isopropylmalate/homocitrate/cit... 411 e-113
ref|YP_001141730.1| hydroxymethylglutaryl-CoA lyase [Aeromo... 410 e-113
ref|ZP_01228079.1| hydroxymethylglutaryl-CoA lyase [Auranti... 410 e-112
ref|XP_001878935.1| predicted protein [Laccaria bicolor S23... 409 e-112
ref|ZP_01913223.1| hydroxymethylglutaryl-CoA lyase [Plesioc... 409 e-112
Sequences not found previously or not previously below threshold:
>sp|Q8HXZ6|HMGCL_MACFA Hydroxymethylglutaryl-CoA lyase, mitochondrial precursor (HMG-CoA
lyase) (HL) (3-hydroxy-3-methylglutarate-CoA lyase)
dbj|BAC20595.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase [Macaca
fascicularis]
Length = 325
Score = 528 bits (1361), Expect = e-148, Method: Composition-based stats.
Identities = 313/325 (96%), Positives = 315/325 (96%)
Query: 1 MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
MAAM KALPRRLVGLASLRAVSTSSM TLPK+VKIVEVGPRDGLQNEKNIVSTPVKIKLI
Sbjct: 1 MAAMTKALPRRLVGLASLRAVSTSSMDTLPKQVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
Query: 61 DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAG 120
DMLSEAGLSVIE TSFVSPKWVPQM DH EVLKGIQKFPGI YPVL PNLKGFEAAVAAG
Sbjct: 61 DMLSEAGLSVIEATSFVSPKWVPQMADHAEVLKGIQKFPGITYPVLIPNLKGFEAAVAAG 120
Query: 121 AKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
AKEV IFGAASELFTKKN+NCSIEESFQRFDAILKAAQSANISVRGYVSC LGCPYEGKI
Sbjct: 121 AKEVSIFGAASELFTKKNVNCSIEESFQRFDAILKAAQSANISVRGYVSCVLGCPYEGKI 180
Query: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVP AALAVHCHDTYGQ
Sbjct: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPPAALAVHCHDTYGQ 240
Query: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL
Sbjct: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
Query: 301 EAGNFICQALNRKTSSKVAQATCKL 325
EAGNFICQALNRKTSSKVAQATCKL
Sbjct: 301 EAGNFICQALNRKTSSKVAQATCKL 325
>ref|NP_000182.2| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase
(hydroxymethylglutaricaciduria) [Homo sapiens]
sp|P35914|HMGCL_HUMAN Hydroxymethylglutaryl-CoA lyase, mitochondrial precursor (HMG-CoA
lyase) (HL) (3-hydroxy-3-methylglutarate-CoA lyase)
gb|AAH10570.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase
(hydroxymethylglutaricaciduria) [Homo sapiens]
gb|AAP88794.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase
(hydroxymethylglutaricaciduria) [Homo sapiens]
emb|CAG33165.1| HMGCL [Homo sapiens]
gb|AAX31956.1| 3-hydroxymethyl-3-methylglutaryl-coenzyme A lyase [synthetic
construct]
gb|AAX31957.1| 3-hydroxymethyl-3-methylglutaryl-coenzyme A lyase [synthetic
construct]
gb|AAX31958.1| 3-hydroxymethyl-3-methylglutaryl-coenzyme A lyase [synthetic
construct]
gb|AAX31959.1| 3-hydroxymethyl-3-methylglutaryl-coenzyme A lyase [synthetic
construct]
gb|EAW95094.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase
(hydroxymethylglutaricaciduria), isoform CRA_a [Homo
sapiens]
gb|ABM83009.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase
(hydroxymethylglutaricaciduria) [synthetic construct]
gb|ABM86202.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase
(hydroxymethylglutaricaciduria) [synthetic construct]
Length = 325
Score = 528 bits (1360), Expect = e-148, Method: Composition-based stats.
Identities = 325/325 (100%), Positives = 325/325 (100%)
Query: 1 MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI
Sbjct: 1 MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
Query: 61 DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAG 120
DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAG
Sbjct: 61 DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAG 120
Query: 121 AKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
AKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI
Sbjct: 121 AKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
Query: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ
Sbjct: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
Query: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL
Sbjct: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
Query: 301 EAGNFICQALNRKTSSKVAQATCKL 325
EAGNFICQALNRKTSSKVAQATCKL
Sbjct: 301 EAGNFICQALNRKTSSKVAQATCKL 325
>gb|AAA92733.1| hydroxymethylglutaryl-CoA lyase [Homo sapiens]
Length = 325
Score = 526 bits (1356), Expect = e-147, Method: Composition-based stats.
Identities = 324/325 (99%), Positives = 324/325 (99%)
Query: 1 MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI
Sbjct: 1 MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
Query: 61 DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAG 120
DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAG
Sbjct: 61 DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAG 120
Query: 121 AKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
AKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI
Sbjct: 121 AKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
Query: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ
Sbjct: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
Query: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
AL NTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL
Sbjct: 241 ALTNTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
Query: 301 EAGNFICQALNRKTSSKVAQATCKL 325
EAGNFICQALNRKTSSKVAQATCKL
Sbjct: 301 EAGNFICQALNRKTSSKVAQATCKL 325
>ref|XP_001166273.1| PREDICTED: 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase
(hydroxymethylglutaricaciduria) isoform 3 [Pan
troglodytes]
Length = 325
Score = 526 bits (1355), Expect = e-147, Method: Composition-based stats.
Identities = 324/325 (99%), Positives = 325/325 (100%)
Query: 1 MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKL+
Sbjct: 1 MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLV 60
Query: 61 DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAG 120
DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAG
Sbjct: 61 DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAG 120
Query: 121 AKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
AKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI
Sbjct: 121 AKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
Query: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ
Sbjct: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
Query: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL
Sbjct: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
Query: 301 EAGNFICQALNRKTSSKVAQATCKL 325
EAGNFICQALNRKTSSKVAQATCKL
Sbjct: 301 EAGNFICQALNRKTSSKVAQATCKL 325
>sp|Q5R9E1|HMGCL_PONPY Hydroxymethylglutaryl-CoA lyase, mitochondrial precursor (HMG-CoA
lyase) (HL) (3-hydroxy-3-methylglutarate-CoA lyase)
emb|CAH91619.1| hypothetical protein [Pongo abelii]
Length = 325
Score = 524 bits (1352), Expect = e-147, Method: Composition-based stats.
Identities = 321/325 (98%), Positives = 322/325 (99%)
Query: 1 MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
MAAMRKA+PRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI
Sbjct: 1 MAAMRKAVPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
Query: 61 DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAG 120
DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAG
Sbjct: 61 DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAG 120
Query: 121 AKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
AKEV IFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI
Sbjct: 121 AKEVAIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
Query: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
SPAKVAEVTKK YSMGCYEISLGDTIGVGTPGIMK MLSAVMQEVPLAALAVHCHDTYGQ
Sbjct: 181 SPAKVAEVTKKLYSMGCYEISLGDTIGVGTPGIMKGMLSAVMQEVPLAALAVHCHDTYGQ 240
Query: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL
Sbjct: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
Query: 301 EAGNFICQALNRKTSSKVAQATCKL 325
EAGNFICQALNRKTSSKVAQATCKL
Sbjct: 301 EAGNFICQALNRKTSSKVAQATCKL 325
>dbj|BAE88248.1| unnamed protein product [Macaca fascicularis]
Length = 325
Score = 523 bits (1348), Expect = e-147, Method: Composition-based stats.
Identities = 312/325 (96%), Positives = 314/325 (96%)
Query: 1 MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
MAAM KALPRRLVGLASLRAVSTSSM TLPK+VKIVEVGPRDGLQN+KNIVSTPVKIKLI
Sbjct: 1 MAAMTKALPRRLVGLASLRAVSTSSMDTLPKQVKIVEVGPRDGLQNKKNIVSTPVKIKLI 60
Query: 61 DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAG 120
DMLSEAGLSVIE TSFVSPKWVPQM DH EVLKGIQKFPGI YPVL PNLKGFEAAVAAG
Sbjct: 61 DMLSEAGLSVIEATSFVSPKWVPQMADHAEVLKGIQKFPGITYPVLIPNLKGFEAAVAAG 120
Query: 121 AKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
AKEV IFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSC LGCPYEGKI
Sbjct: 121 AKEVSIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCVLGCPYEGKI 180
Query: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVP AALAVHCHDTYGQ
Sbjct: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPPAALAVHCHDTYGQ 240
Query: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQK L
Sbjct: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKPL 300
Query: 301 EAGNFICQALNRKTSSKVAQATCKL 325
EAGNFICQALNRKTSSKVAQATCKL
Sbjct: 301 EAGNFICQALNRKTSSKVAQATCKL 325
>ref|NP_077362.1| 3-hydroxy-3-methylglutaryl-Coenzyme A lyase [Rattus norvegicus]
sp|P97519|HMGCL_RAT Hydroxymethylglutaryl-CoA lyase, mitochondrial precursor (HMG-CoA
lyase) (HL) (3-hydroxy-3-methylglutarate-CoA lyase)
emb|CAA71148.1| 3-hydroxy-3-methylglutaryl CoA lyase [Rattus norvegicus]
gb|AAH61797.1| 3-hydroxy-3-methylglutaryl-Coenzyme A lyase [Rattus norvegicus]
gb|EDL80779.1| 3-hydroxy-3-methylglutaryl-Coenzyme A lyase, isoform CRA_a [Rattus
norvegicus]
Length = 325
Score = 523 bits (1347), Expect = e-146, Method: Composition-based stats.
Identities = 289/325 (88%), Positives = 311/325 (95%)
Query: 1 MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
MA +RKA P+RLVGLASLRA STSSMGTLPKRVKIVEVGPRDGLQNEK+IV TPVKIKLI
Sbjct: 1 MATVRKAFPQRLVGLASLRAASTSSMGTLPKRVKIVEVGPRDGLQNEKSIVPTPVKIKLI 60
Query: 61 DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAG 120
DMLSEAGL VIE TSFVSPKWVPQM DH++VLKGIQKFPGINYPVLTPN+KGFE AVAAG
Sbjct: 61 DMLSEAGLPVIEATSFVSPKWVPQMADHSDVLKGIQKFPGINYPVLTPNMKGFEEAVAAG 120
Query: 121 AKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
AKEV IFGAASELFT+KN+NCSIEESFQRFD +++AA++A+ISVRGYVSCALGCPYEGK+
Sbjct: 121 AKEVSIFGAASELFTRKNVNCSIEESFQRFDGVMQAARAASISVRGYVSCALGCPYEGKV 180
Query: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
SPAKVAEV KK YSMGCYEISLGDTIGVGTPG+MKDML+AV+ EVP+AALAVHCHDTYGQ
Sbjct: 181 SPAKVAEVAKKLYSMGCYEISLGDTIGVGTPGLMKDMLTAVLHEVPVAALAVHCHDTYGQ 240
Query: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
ALANTL+ALQMGVSVVDSSVAGLGGCPYA+GASGNLATEDLVYML GLGIHTGVNLQKLL
Sbjct: 241 ALANTLVALQMGVSVVDSSVAGLGGCPYAKGASGNLATEDLVYMLTGLGIHTGVNLQKLL 300
Query: 301 EAGNFICQALNRKTSSKVAQATCKL 325
EAG+FICQALNRKTSSKVAQATCKL
Sbjct: 301 EAGDFICQALNRKTSSKVAQATCKL 325
>ref|NP_032280.2| 3-hydroxy-3-methylglutaryl-Coenzyme A lyase [Mus musculus]
gb|AAH25440.1| Hmgcl protein [Mus musculus]
dbj|BAE32329.1| unnamed protein product [Mus musculus]
dbj|BAE20956.1| unnamed protein product [Mus musculus]
dbj|BAE26328.1| unnamed protein product [Mus musculus]
emb|CAM15901.1| 3-hydroxy-3-methylglutaryl-Coenzyme A lyase [Mus musculus]
gb|EDL29963.1| 3-hydroxy-3-methylglutaryl-Coenzyme A lyase [Mus musculus]
Length = 325
Score = 521 bits (1344), Expect = e-146, Method: Composition-based stats.
Identities = 286/325 (88%), Positives = 308/325 (94%)
Query: 1 MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
MA++RKA PRRLVGL SLRAVSTSSMGTLPK+VKIVEVGPRDGLQNEK+IV TPVKI+LI
Sbjct: 1 MASVRKAFPRRLVGLTSLRAVSTSSMGTLPKQVKIVEVGPRDGLQNEKSIVPTPVKIRLI 60
Query: 61 DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAG 120
DMLSEAGL VIE TSFVSPKWVPQM DH++VLKGIQKFPGINYPVLTPN+KGFE AVAAG
Sbjct: 61 DMLSEAGLPVIEATSFVSPKWVPQMADHSDVLKGIQKFPGINYPVLTPNMKGFEEAVAAG 120
Query: 121 AKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
AKEV +FGA SELFT+KN NCSIEESFQRF +++AAQ+A+ISVRGYVSCALGCPYEGK+
Sbjct: 121 AKEVSVFGAVSELFTRKNANCSIEESFQRFAGVMQAAQAASISVRGYVSCALGCPYEGKV 180
Query: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
SPAKVAEV KK YSMGCYEISLGDTIGVGTPG+MKDML+AVM EVP+ ALAVHCHDTYGQ
Sbjct: 181 SPAKVAEVAKKLYSMGCYEISLGDTIGVGTPGLMKDMLTAVMHEVPVTALAVHCHDTYGQ 240
Query: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
ALANTL+ALQMGVSVVDSSVAGLGGCPYA+GASGNLATEDLVYML GLGIHTGVNLQKLL
Sbjct: 241 ALANTLVALQMGVSVVDSSVAGLGGCPYAKGASGNLATEDLVYMLNGLGIHTGVNLQKLL 300
Query: 301 EAGNFICQALNRKTSSKVAQATCKL 325
EAG+FICQALNRKTSSKVAQATCKL
Sbjct: 301 EAGDFICQALNRKTSSKVAQATCKL 325
>dbj|BAE26056.1| unnamed protein product [Mus musculus]
Length = 325
Score = 520 bits (1341), Expect = e-146, Method: Composition-based stats.
Identities = 284/325 (87%), Positives = 306/325 (94%)
Query: 1 MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
MA++RKA PRRLVGL SLRAVSTSSMGTLPK+VKIVEVGPRDGLQNEK+IV TPVKI+LI
Sbjct: 1 MASVRKAFPRRLVGLTSLRAVSTSSMGTLPKQVKIVEVGPRDGLQNEKSIVPTPVKIRLI 60
Query: 61 DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAG 120
DMLSEAGL VIE TSFVSPKWVPQM DH++VLKGIQKFPGINYPVLTPN+KGFE AVAAG
Sbjct: 61 DMLSEAGLPVIEATSFVSPKWVPQMADHSDVLKGIQKFPGINYPVLTPNMKGFEEAVAAG 120
Query: 121 AKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
AKEV +FGA SELFT+KN NCSIEESFQRF +++AAQ+A+ISVRGYVSCALGCPYEGK+
Sbjct: 121 AKEVSVFGAVSELFTRKNANCSIEESFQRFAGVMQAAQAASISVRGYVSCALGCPYEGKV 180
Query: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
SPAKVAEV KK YSMGCYEISLGDTIGVGTP MKDML+AVM EVP+ ALAVHCHDTYGQ
Sbjct: 181 SPAKVAEVAKKLYSMGCYEISLGDTIGVGTPDXMKDMLTAVMHEVPVTALAVHCHDTYGQ 240
Query: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
ALANTL+ALQMGVSVV+SSVAGLGGCPYA+GASGNLATEDLVYML GLGIHTGVNLQKLL
Sbjct: 241 ALANTLVALQMGVSVVNSSVAGLGGCPYAKGASGNLATEDLVYMLNGLGIHTGVNLQKLL 300
Query: 301 EAGNFICQALNRKTSSKVAQATCKL 325
EAG+FICQALNRKTSSKVAQATCKL
Sbjct: 301 EAGDFICQALNRKTSSKVAQATCKL 325
>ref|NP_001068600.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase
(hydroxymethylglutaricaciduria) [Bos taurus]
sp|Q29448|HMGCL_BOVIN Hydroxymethylglutaryl-CoA lyase, mitochondrial precursor (HMG-CoA
lyase) (HL) (3-hydroxy-3-methylglutarate-CoA lyase)
gb|AAI18277.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase
(hydroxymethylglutaricaciduria) [Bos taurus]
Length = 325
Score = 520 bits (1341), Expect = e-146, Method: Composition-based stats.
Identities = 289/325 (88%), Positives = 305/325 (93%)
Query: 1 MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
MA ++K LPRRLVGLA+LRAVSTSS+GT PK+VKIVEVGPRDGLQNEKNIV TPVKIKLI
Sbjct: 1 MATVKKVLPRRLVGLATLRAVSTSSVGTFPKQVKIVEVGPRDGLQNEKNIVPTPVKIKLI 60
Query: 61 DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAG 120
DMLSEAGL V+E TSFVSPKWVPQM DH EVLKGIQKFPG+NYPVLTPN KGF+AAVAAG
Sbjct: 61 DMLSEAGLPVVEATSFVSPKWVPQMADHAEVLKGIQKFPGVNYPVLTPNFKGFQAAVAAG 120
Query: 121 AKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
AKEV IFGAASELFTKKNINCSI+ES QRFD ILKAA++A ISVRGYVSC LGCPYEGKI
Sbjct: 121 AKEVAIFGAASELFTKKNINCSIDESLQRFDEILKAARAAGISVRGYVSCVLGCPYEGKI 180
Query: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
SPAKVAEVTKK YSMGCYEISLGDTIGVGTPG MKDMLSAV+QEVP+ ALAVHCHDTYGQ
Sbjct: 181 SPAKVAEVTKKLYSMGCYEISLGDTIGVGTPGAMKDMLSAVLQEVPVTALAVHCHDTYGQ 240
Query: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
ALANTL ALQMGVSV+DSSVAGLGGCPYAQGASGNLATEDLVYML GLGIHTGVNLQKLL
Sbjct: 241 ALANTLTALQMGVSVMDSSVAGLGGCPYAQGASGNLATEDLVYMLAGLGIHTGVNLQKLL 300
Query: 301 EAGNFICQALNRKTSSKVAQATCKL 325
EAG FICQALNR+T+SKVAQATCKL
Sbjct: 301 EAGAFICQALNRRTNSKVAQATCKL 325
>ref|XP_001504254.1| PREDICTED: similar to interleukin 13 receptor alpha 1-binding
protein-1 [Equus caballus]
Length = 325
Score = 519 bits (1337), Expect = e-145, Method: Composition-based stats.
Identities = 296/325 (91%), Positives = 306/325 (94%)
Query: 1 MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
MA +RK LPRRL GLASLRAVSTSS+GT PKRVKIVEVGPRDGLQNEKNIV T +KIKLI
Sbjct: 1 MATVRKGLPRRLAGLASLRAVSTSSVGTFPKRVKIVEVGPRDGLQNEKNIVPTAMKIKLI 60
Query: 61 DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAG 120
DMLSEAGL VIE TSFVSPKWVPQM DHTEVLKGIQKFPGINYPVLTPN KGF+AAVAAG
Sbjct: 61 DMLSEAGLPVIEATSFVSPKWVPQMADHTEVLKGIQKFPGINYPVLTPNFKGFQAAVAAG 120
Query: 121 AKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
AKEV +FGAASELFTKKNINCSIEES QRF +LKAA++A+I VRGYVSCALGCPYEGKI
Sbjct: 121 AKEVAVFGAASELFTKKNINCSIEESIQRFGEVLKAARAASIPVRGYVSCALGCPYEGKI 180
Query: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
SPAKVAEVTKK YSMGCYEISLGDTIGVGTPG MKDMLSAVMQEVP+AALAVHCHDTYGQ
Sbjct: 181 SPAKVAEVTKKMYSMGCYEISLGDTIGVGTPGGMKDMLSAVMQEVPVAALAVHCHDTYGQ 240
Query: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYML GLGIHTGVNLQKLL
Sbjct: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLAGLGIHTGVNLQKLL 300
Query: 301 EAGNFICQALNRKTSSKVAQATCKL 325
EAG FICQALNRKTSSKVAQATCKL
Sbjct: 301 EAGTFICQALNRKTSSKVAQATCKL 325
>gb|AAB03107.1| 3-hydroxy-3-methylglutaryl-CoA lyase
Length = 325
Score = 516 bits (1331), Expect = e-145, Method: Composition-based stats.
Identities = 284/325 (87%), Positives = 308/325 (94%)
Query: 1 MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
MA++RKA PRRLVGL SLRAVSTSSMGTLPK+VKIVEVGPRDGLQNEK+IV TPVKI+LI
Sbjct: 1 MASVRKAFPRRLVGLTSLRAVSTSSMGTLPKQVKIVEVGPRDGLQNEKSIVPTPVKIRLI 60
Query: 61 DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAG 120
D++SEAGL VIE TSFVSPKWVPQM DH++VLKGIQKFPGINYPVLTPN+KGFE AVAAG
Sbjct: 61 DIVSEAGLPVIEATSFVSPKWVPQMADHSDVLKGIQKFPGINYPVLTPNMKGFEEAVAAG 120
Query: 121 AKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
AKEV +FGA SELFT+KN NCSIEESFQRF +++AAQ+A+ISVRGYVSCALGCPYEGK+
Sbjct: 121 AKEVSVFGAVSELFTRKNANCSIEESFQRFAGVMQAAQAASISVRGYVSCALGCPYEGKV 180
Query: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
SPAKVAEV KK YSMGCYEISLGDTIGVGTPG+MKDML+AVM EVP+ ALAVHCHDTYGQ
Sbjct: 181 SPAKVAEVAKKLYSMGCYEISLGDTIGVGTPGLMKDMLTAVMHEVPVTALAVHCHDTYGQ 240
Query: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
ALANTL+ALQMGVSVVDSSVAGLGGCPYA+GASGNLATEDLVYML GLGIHTGVNLQKLL
Sbjct: 241 ALANTLVALQMGVSVVDSSVAGLGGCPYAKGASGNLATEDLVYMLNGLGIHTGVNLQKLL 300
Query: 301 EAGNFICQALNRKTSSKVAQATCKL 325
EAG+FICQALNRKTSSKVAQATCKL
Sbjct: 301 EAGDFICQALNRKTSSKVAQATCKL 325
>sp|P38060|HMGCL_MOUSE Hydroxymethylglutaryl-CoA lyase, mitochondrial precursor (HMG-CoA
lyase) (HL) (3-hydroxy-3-methylglutarate-CoA lyase)
pir||I57009 3-Hydroxy-3-methylglutaryl coenzyme A lyase - mouse
gb|AAB27965.1| 3-Hydroxy-3-methylglutaryl coenzyme A lyase; HL [Mus sp.]
Length = 325
Score = 514 bits (1326), Expect = e-144, Method: Composition-based stats.
Identities = 283/325 (87%), Positives = 305/325 (93%)
Query: 1 MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
MA++RKA PRRLVGL SLRAVSTSSMGTLPK+VKIVEVGPRDGLQNEK+IV TPVKI+LI
Sbjct: 1 MASVRKAFPRRLVGLTSLRAVSTSSMGTLPKQVKIVEVGPRDGLQNEKSIVPTPVKIRLI 60
Query: 61 DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAG 120
DMLSEAGL VIE TSFVSP WVPQM DH++VLKGIQKFPGINYPVLTPN+KGFE AVAAG
Sbjct: 61 DMLSEAGLPVIEATSFVSPNWVPQMADHSDVLKGIQKFPGINYPVLTPNMKGFEEAVAAG 120
Query: 121 AKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
AKEV +FGA SELFT+KN NCSIEESFQRF +++AAQ+A+ISVRGYVSCALGCPYEGK+
Sbjct: 121 AKEVSVFGAVSELFTRKNANCSIEESFQRFAGVMQAAQAASISVRGYVSCALGCPYEGKV 180
Query: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
SPAKVAEV KK YSMGCYEISLGDTIGVGTPG+MKDML+AVM EVP+ AL VHCHDT GQ
Sbjct: 181 SPAKVAEVAKKLYSMGCYEISLGDTIGVGTPGLMKDMLTAVMHEVPVTALGVHCHDTIGQ 240
Query: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
ALANTL+ALQMGVSVVDSSVAGLGGCPYA+GASGNLATEDLVYML GLGIHTGVNLQKLL
Sbjct: 241 ALANTLVALQMGVSVVDSSVAGLGGCPYAKGASGNLATEDLVYMLNGLGIHTGVNLQKLL 300
Query: 301 EAGNFICQALNRKTSSKVAQATCKL 325
EAG+FICQALNRKTSSKVAQATCKL
Sbjct: 301 EAGDFICQALNRKTSSKVAQATCKL 325
>ref|XP_535360.2| PREDICTED: similar to Hydroxymethylglutaryl-CoA lyase,
mitochondrial precursor (HMG-CoA lyase) (HL)
(3-hydroxy-3-methylglutarate-CoA lyase) isoform 1 [Canis
familiaris]
Length = 325
Score = 506 bits (1304), Expect = e-141, Method: Composition-based stats.
Identities = 283/325 (87%), Positives = 295/325 (90%)
Query: 1 MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
MAAMRK +PRRLVGLASLRAVST S+GT PK+VKIVEVG RDGLQNEKNIVST KIKLI
Sbjct: 1 MAAMRKVVPRRLVGLASLRAVSTFSLGTFPKQVKIVEVGARDGLQNEKNIVSTSTKIKLI 60
Query: 61 DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAG 120
DMLSEAGL VIE TSFVSPKWVPQM D EVLKGIQKFPGINYPVLTPN+KGF+AAVAAG
Sbjct: 61 DMLSEAGLPVIEATSFVSPKWVPQMADCAEVLKGIQKFPGINYPVLTPNIKGFQAAVAAG 120
Query: 121 AKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
AKEV IF AASE FTKKN NCSI+E QR D I +AAQ+A I VRGYVSC LGCPYEGKI
Sbjct: 121 AKEVTIFAAASEQFTKKNTNCSIDECLQRSDDIFRAAQAAGIPVRGYVSCVLGCPYEGKI 180
Query: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
SPAKV EV KK YSMGCYEISLGDTIGVGTPG+MKDMLSAVM EVP++ALAVHCHDTYGQ
Sbjct: 181 SPAKVVEVAKKIYSMGCYEISLGDTIGVGTPGVMKDMLSAVMHEVPVSALAVHCHDTYGQ 240
Query: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
ALANTLMALQMGVSVVDSSVAGLGGCPYA+GASGNLATEDLVYML GLGIHTGVNLQKLL
Sbjct: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYARGASGNLATEDLVYMLSGLGIHTGVNLQKLL 300
Query: 301 EAGNFICQALNRKTSSKVAQATCKL 325
EAG FICQALNRKTSSKVAQA CKL
Sbjct: 301 EAGTFICQALNRKTSSKVAQAACKL 325
>ref|XP_513200.2| PREDICTED: similar to 3-hydroxymethyl-3-methylglutaryl-Coenzyme A
lyase (hydroxymethylglutaricaciduria) isoform 4 [Pan
troglodytes]
Length = 316
Score = 497 bits (1282), Expect = e-139, Method: Composition-based stats.
Identities = 304/306 (99%), Positives = 305/306 (99%)
Query: 20 AVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSP 79
VSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKL+DMLSEAGLSVIETTSFVSP
Sbjct: 11 EVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLVDMLSEAGLSVIETTSFVSP 70
Query: 80 KWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNI 139
KWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNI
Sbjct: 71 KWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNI 130
Query: 140 NCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYE 199
NCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYE
Sbjct: 131 NCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYE 190
Query: 200 ISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSS 259
ISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSS
Sbjct: 191 ISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSS 250
Query: 260 VAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVA 319
VAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVA
Sbjct: 251 VAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVA 310
Query: 320 QATCKL 325
QATCKL
Sbjct: 311 QATCKL 316
>gb|AAB19099.1| hydroxymethylglutaryl-CoA lyase
Length = 305
Score = 497 bits (1280), Expect = e-139, Method: Composition-based stats.
Identities = 304/305 (99%), Positives = 305/305 (100%)
Query: 21 VSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPK 80
VSTSSMGTLPKRVKIVEVGP+DGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPK
Sbjct: 1 VSTSSMGTLPKRVKIVEVGPQDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPK 60
Query: 81 WVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNIN 140
WVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNIN
Sbjct: 61 WVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNIN 120
Query: 141 CSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEI 200
CSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEI
Sbjct: 121 CSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEI 180
Query: 201 SLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSV 260
SLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSV
Sbjct: 181 SLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSV 240
Query: 261 AGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQ 320
AGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQ
Sbjct: 241 AGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQ 300
Query: 321 ATCKL 325
ATCKL
Sbjct: 301 ATCKL 305
>ref|NP_001085152.1| hypothetical protein LOC432233 [Xenopus laevis]
gb|AAH72247.1| MGC82338 protein [Xenopus laevis]
Length = 328
Score = 495 bits (1276), Expect = e-138, Method: Composition-based stats.
Identities = 230/312 (73%), Positives = 264/312 (84%)
Query: 14 GLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIET 73
LA LR + + + + PK VKIVEVGPRDGLQNEK +V T VKI LI+MLSEAGL IE
Sbjct: 17 PLAILRQIGSLPIQSFPKEVKIVEVGPRDGLQNEKTVVPTDVKIHLINMLSEAGLQAIEA 76
Query: 74 TSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASEL 133
TSFVSPKWVPQM DH V++GI+K+P I+YPVLTPNL GF+AAV GAKEV IFGAASEL
Sbjct: 77 TSFVSPKWVPQMADHKNVMQGIKKYPNISYPVLTPNLTGFQAAVECGAKEVAIFGAASEL 136
Query: 134 FTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFY 193
F+KKNINCSI+ES QRF A++ A+ ANI VRGYVSC LGCPYEGK++P+KVAEV K +
Sbjct: 137 FSKKNINCSIDESLQRFKAVITEAKEANIPVRGYVSCVLGCPYEGKVAPSKVAEVAYKMF 196
Query: 194 SMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGV 253
SMGCYEISLGDTIGVGTPG M+DMLSAV+ VP ALAVHCHDTYGQALAN L+ALQMGV
Sbjct: 197 SMGCYEISLGDTIGVGTPGGMRDMLSAVLDVVPAKALAVHCHDTYGQALANILVALQMGV 256
Query: 254 SVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRK 313
VVD+SVAGLGGCPYAQGASGN+ATED+VYML GLGI TG++L+KL EAG FIC+AL +K
Sbjct: 257 QVVDASVAGLGGCPYAQGASGNVATEDVVYMLHGLGIQTGIDLKKLTEAGAFICKALGKK 316
Query: 314 TSSKVAQATCKL 325
+ SKV+QA CKL
Sbjct: 317 SHSKVSQAICKL 328
>emb|CAI23161.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase
(hydroxymethylglutaricaciduria) [Homo sapiens]
gb|EAW95095.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase
(hydroxymethylglutaricaciduria), isoform CRA_b [Homo
sapiens]
Length = 300
Score = 493 bits (1271), Expect = e-138, Method: Composition-based stats.
Identities = 300/300 (100%), Positives = 300/300 (100%)
Query: 26 MGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQM 85
MGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQM
Sbjct: 1 MGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQM 60
Query: 86 GDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNINCSIEE 145
GDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNINCSIEE
Sbjct: 61 GDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNINCSIEE 120
Query: 146 SFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLGDT 205
SFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLGDT
Sbjct: 121 SFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLGDT 180
Query: 206 IGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGG 265
IGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGG
Sbjct: 181 IGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGG 240
Query: 266 CPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQATCKL 325
CPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQATCKL
Sbjct: 241 CPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQATCKL 300
>ref|NP_061909.2| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-like 1 isoform a
[Homo sapiens]
sp|Q8TB92|HMGC2_HUMAN Probable 3-hydroxymethyl-3-methylglutaryl-CoA lyase 2
(3-hydroxymethyl-3-methylglutaryl-CoA lyase-like protein
1)
gb|EAX04443.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-like 1, isoform
CRA_b [Homo sapiens]
Length = 370
Score = 492 bits (1268), Expect = e-137, Method: Composition-based stats.
Identities = 216/311 (69%), Positives = 260/311 (83%)
Query: 11 RLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSV 70
L G + TS + LP+ VKIVEVGPRDGLQNEK IV T +KI+ I+ LS+ GLSV
Sbjct: 56 SLAGTVACIHWETSQLSGLPEFVKIVEVGPRDGLQNEKVIVPTDIKIEFINRLSQTGLSV 115
Query: 71 IETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAA 130
IE TSFVS +WVPQM DHTEV+KGI ++PG+ YPVLTPNL+GF AVAAGA E+ +FGAA
Sbjct: 116 IEVTSFVSSRWVPQMADHTEVMKGIHQYPGVRYPVLTPNLQGFHHAVAAGATEISVFGAA 175
Query: 131 SELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTK 190
SE F+KKNINCSIEES +F+ ++K+A+ NI RGYVSCALGCPYEG I+P KV EV+K
Sbjct: 176 SESFSKKNINCSIEESMGKFEEVVKSARHMNIPARGYVSCALGCPYEGSITPQKVTEVSK 235
Query: 191 KFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQ 250
+ Y MGCYEISLGDTIGVGTPG MK ML +VM+E+P ALAVHCHDTYGQALAN L ALQ
Sbjct: 236 RLYGMGCYEISLGDTIGVGTPGSMKRMLESVMKEIPPGALAVHCHDTYGQALANILTALQ 295
Query: 251 MGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQAL 310
MG++VVDS+V+GLGGCPYA+GASGN+ATEDL+YML GLG++TGVNL K++EAG+FIC+A+
Sbjct: 296 MGINVVDSAVSGLGGCPYAKGASGNVATEDLIYMLNGLGLNTGVNLYKVMEAGDFICKAV 355
Query: 311 NRKTSSKVAQA 321
N+ T+SKVAQA
Sbjct: 356 NKTTNSKVAQA 366
>ref|XP_001166216.1| PREDICTED: similar to 3-hydroxymethyl-3-methylglutaryl-Coenzyme A
lyase (hydroxymethylglutaricaciduria) isoform 2 [Pan
troglodytes]
Length = 300
Score = 492 bits (1267), Expect = e-137, Method: Composition-based stats.
Identities = 299/300 (99%), Positives = 300/300 (100%)
Query: 26 MGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQM 85
MGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKL+DMLSEAGLSVIETTSFVSPKWVPQM
Sbjct: 1 MGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLVDMLSEAGLSVIETTSFVSPKWVPQM 60
Query: 86 GDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNINCSIEE 145
GDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNINCSIEE
Sbjct: 61 GDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNINCSIEE 120
Query: 146 SFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLGDT 205
SFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLGDT
Sbjct: 121 SFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLGDT 180
Query: 206 IGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGG 265
IGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGG
Sbjct: 181 IGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGG 240
Query: 266 CPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQATCKL 325
CPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQATCKL
Sbjct: 241 CPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQATCKL 300
>ref|XP_538973.2| PREDICTED: similar to 3-hydroxymethyl-3-methylglutaryl-Coenzyme A
lyase-like 1 [Canis familiaris]
Length = 343
Score = 491 bits (1264), Expect = e-137, Method: Composition-based stats.
Identities = 215/302 (71%), Positives = 259/302 (85%)
Query: 20 AVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSP 79
A TS + LP+ VKIVEVGPRDGLQNEK IV T +KI+ I+ LS+ GLSVIE TSFVS
Sbjct: 35 AQETSQLSGLPEYVKIVEVGPRDGLQNEKVIVPTDIKIEFINQLSQTGLSVIEVTSFVSS 94
Query: 80 KWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNI 139
KWVPQM DHTEV+KGI ++PG+ YPVLTPNL+GF AVAAGA E+ +FGAASE F+K+NI
Sbjct: 95 KWVPQMADHTEVMKGIHQYPGVRYPVLTPNLQGFHRAVAAGATEISVFGAASESFSKRNI 154
Query: 140 NCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYE 199
NCSIEES ++F+ ++K+A+ NI RGYVSCALGCPYEG I+P KV EV+KK Y MGCYE
Sbjct: 155 NCSIEESMEKFEEVVKSARHMNIPARGYVSCALGCPYEGNITPQKVTEVSKKLYGMGCYE 214
Query: 200 ISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSS 259
ISLGDT GVGTPG MK ML +VM+E+P +ALAVHCHDTYGQALAN L ALQMG++VVDS+
Sbjct: 215 ISLGDTTGVGTPGSMKRMLESVMKEIPSSALAVHCHDTYGQALANILTALQMGINVVDSA 274
Query: 260 VAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVA 319
V+GLGGCPYA+GASGN+ATEDL+YML GLG++TGVNL K++EAG+FIC+A+N+ T+SKVA
Sbjct: 275 VSGLGGCPYAKGASGNVATEDLIYMLNGLGLNTGVNLYKVMEAGDFICKAVNKTTNSKVA 334
Query: 320 QA 321
QA
Sbjct: 335 QA 336
>pdb|2CW6|A Chain A, Crystal Structure Of Human Hmg-Coa Lyase: Insights Into
Catalysis And The Molecular Basis For
Hydroxymethylglutaric Aciduria
pdb|2CW6|B Chain B, Crystal Structure Of Human Hmg-Coa Lyase: Insights Into
Catalysis And The Molecular Basis For
Hydroxymethylglutaric Aciduria
pdb|2CW6|C Chain C, Crystal Structure Of Human Hmg-Coa Lyase: Insights Into
Catalysis And The Molecular Basis For
Hydroxymethylglutaric Aciduria
pdb|2CW6|D Chain D, Crystal Structure Of Human Hmg-Coa Lyase: Insights Into
Catalysis And The Molecular Basis For
Hydroxymethylglutaric Aciduria
pdb|2CW6|E Chain E, Crystal Structure Of Human Hmg-Coa Lyase: Insights Into
Catalysis And The Molecular Basis For
Hydroxymethylglutaric Aciduria
pdb|2CW6|F Chain F, Crystal Structure Of Human Hmg-Coa Lyase: Insights Into
Catalysis And The Molecular Basis For
Hydroxymethylglutaric Aciduria
Length = 298
Score = 491 bits (1264), Expect = e-137, Method: Composition-based stats.
Identities = 298/298 (100%), Positives = 298/298 (100%)
Query: 28 TLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQMGD 87
TLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQMGD
Sbjct: 1 TLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQMGD 60
Query: 88 HTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNINCSIEESF 147
HTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNINCSIEESF
Sbjct: 61 HTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNINCSIEESF 120
Query: 148 QRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLGDTIG 207
QRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLGDTIG
Sbjct: 121 QRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLGDTIG 180
Query: 208 VGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGGCP 267
VGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGGCP
Sbjct: 181 VGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGGCP 240
Query: 268 YAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQATCKL 325
YAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQATCKL
Sbjct: 241 YAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQATCKL 298
>ref|NP_957509.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase
(hydroxymethylglutaricaciduria) [Danio rerio]
gb|AAH46023.1| Zgc:56248 [Danio rerio]
Length = 340
Score = 490 bits (1262), Expect = e-137, Method: Composition-based stats.
Identities = 236/321 (73%), Positives = 274/321 (85%)
Query: 5 RKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLS 64
R L L +VS ++ LP+RVKIVEVGPRDGLQNEK IV T VKI+LIDMLS
Sbjct: 20 RPVLHCAASALIRSVSVSAAASQALPERVKIVEVGPRDGLQNEKTIVPTEVKIRLIDMLS 79
Query: 65 EAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEV 124
EAGL VIE TSFVSPKWVPQM D EV++G+ K PG+NYPVLTPNLKGF+AAV AGAKEV
Sbjct: 80 EAGLPVIEATSFVSPKWVPQMADQEEVMRGLHKKPGVNYPVLTPNLKGFQAAVKAGAKEV 139
Query: 125 VIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAK 184
IFGAASELF+KKNINCS+EES RF+ ++ AA+ +SVRGYVSC LGCPYEGK+SP+K
Sbjct: 140 AIFGAASELFSKKNINCSVEESLVRFEEVMTAAKQEGVSVRGYVSCVLGCPYEGKVSPSK 199
Query: 185 VAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALAN 244
VAEV K+ YSMGCYE+SLGDTIGVGTPG M +ML+AV +E+P+ ALAVHCHDTYGQALAN
Sbjct: 200 VAEVAKRLYSMGCYEVSLGDTIGVGTPGGMTEMLNAVKKELPVEALAVHCHDTYGQALAN 259
Query: 245 TLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGN 304
L+ALQ GVSVVDSSVAGLGGCPYAQGASGN+ATED+VYML GLGIHTGV+L +LL+AG+
Sbjct: 260 ILVALQNGVSVVDSSVAGLGGCPYAQGASGNVATEDVVYMLHGLGIHTGVDLPRLLDAGS 319
Query: 305 FICQALNRKTSSKVAQATCKL 325
FIC ++NR+T+SKVAQA+CKL
Sbjct: 320 FICHSINRRTNSKVAQASCKL 340
>ref|XP_001363832.1| PREDICTED: similar to alpha-2-macroglobulin receptor [Monodelphis
domestica]
Length = 327
Score = 489 bits (1261), Expect = e-137, Method: Composition-based stats.
Identities = 252/319 (78%), Positives = 282/319 (88%)
Query: 5 RKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLS 64
R P RL G +SLRA+S+SS+ PK+VKIVEVGPRDGLQNEK+I+ T +KIKLIDMLS
Sbjct: 6 RTFPPLRLAGTSSLRAISSSSLDAFPKQVKIVEVGPRDGLQNEKHILPTQMKIKLIDMLS 65
Query: 65 EAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEV 124
AGL VIE TSFVSPKWVPQM DH EVL+GI+KFPGI+YPVLTPNL+GF+AAVAAGAKEV
Sbjct: 66 AAGLPVIEATSFVSPKWVPQMADHAEVLQGIEKFPGISYPVLTPNLRGFQAAVAAGAKEV 125
Query: 125 VIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAK 184
IFGAASELF+KKNINCSIEES+QRF+ +L A+ ANI VRGYVSC LGCPYEGK+SPAK
Sbjct: 126 AIFGAASELFSKKNINCSIEESYQRFEEVLTEARCANIPVRGYVSCVLGCPYEGKVSPAK 185
Query: 185 VAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALAN 244
VAEV KK YSMGC+EISLGDTIGVGTP MK+MLSAVM+E+P++ALAVHCHDTYGQALAN
Sbjct: 186 VAEVAKKLYSMGCFEISLGDTIGVGTPLGMKNMLSAVMKEMPVSALAVHCHDTYGQALAN 245
Query: 245 TLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGN 304
LMALQMGVSVVDSSVAGLGGCPY+ GASGN+ATEDL+YML GLGI TGVNLQKL +AG
Sbjct: 246 ILMALQMGVSVVDSSVAGLGGCPYSPGASGNVATEDLLYMLNGLGIDTGVNLQKLTDAGK 305
Query: 305 FICQALNRKTSSKVAQATC 323
FIC+ALNRK SSKVA A
Sbjct: 306 FICKALNRKNSSKVATAIS 324
>ref|XP_417834.1| PREDICTED: similar to Hydroxymethylglutaryl-CoA lyase (HMG-CoA
lyase) (HL) (3-hydroxy-3-methylglutarate-CoA lyase)
[Gallus gallus]
Length = 319
Score = 489 bits (1260), Expect = e-136, Method: Composition-based stats.
Identities = 251/325 (77%), Positives = 288/325 (88%), Gaps = 6/325 (1%)
Query: 1 MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
MAA+R+ LPR V SLR VST++ P+RVK+VEVGPRDGLQNEK++V TPVKI+LI
Sbjct: 1 MAAVRRLLPRWAV---SLRPVSTAA---FPQRVKVVEVGPRDGLQNEKSVVPTPVKIRLI 54
Query: 61 DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAG 120
DMLSE GL VIE TSFVSP+WVPQM DH EV++GI K PG++YPVLTPNLKGF+AAVAAG
Sbjct: 55 DMLSETGLPVIEATSFVSPRWVPQMADHAEVMQGINKLPGVSYPVLTPNLKGFQAAVAAG 114
Query: 121 AKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
AKEV IFGAASELFTKKNINCSIEES +RF ++ AA++A+I VRGYVSC LGCPYEG I
Sbjct: 115 AKEVSIFGAASELFTKKNINCSIEESLERFSEVMNAARAASIPVRGYVSCVLGCPYEGNI 174
Query: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
S AKVAEV+KK YSMGCYEISLGDTIG+GTPG MK+ML+AVM+EVP+ ALAVHCHDTYGQ
Sbjct: 175 SAAKVAEVSKKMYSMGCYEISLGDTIGIGTPGSMKEMLAAVMKEVPVGALAVHCHDTYGQ 234
Query: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
ALAN L+ALQMGVSVVD+SVAGLGGCPYAQGASGN+ATEDLVYML GLGIHTGV+LQKL+
Sbjct: 235 ALANILVALQMGVSVVDASVAGLGGCPYAQGASGNVATEDLVYMLNGLGIHTGVDLQKLM 294
Query: 301 EAGNFICQALNRKTSSKVAQATCKL 325
+ G FIC ALNR+T+SKV+QA C+L
Sbjct: 295 DTGTFICNALNRRTNSKVSQAACRL 319
>ref|XP_001499476.1| PREDICTED: similar to 3-hydroxymethyl-3-methylglutaryl-Coenzyme A
lyase-like 1 [Equus caballus]
Length = 435
Score = 487 bits (1255), Expect = e-136, Method: Composition-based stats.
Identities = 215/305 (70%), Positives = 259/305 (84%)
Query: 20 AVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSP 79
A +S LP+ VKIVEVGPRDGLQNEK IV T +KI+ I+ LS+ GLSVIE TSFVS
Sbjct: 123 AQESSQFSGLPEYVKIVEVGPRDGLQNEKVIVPTDIKIEFINQLSQTGLSVIEVTSFVSS 182
Query: 80 KWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNI 139
+WVPQM DHTEV+KGI + PG+ YPVLTPNL+GF AVAAGA E+ +FGAASE F+KKNI
Sbjct: 183 RWVPQMADHTEVMKGIHQHPGVRYPVLTPNLQGFHRAVAAGATEISVFGAASESFSKKNI 242
Query: 140 NCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYE 199
NCSIEES ++F+ ++K+A+ NI RGYVSCALGCPYEG I+ KV EV+K+ Y MGCYE
Sbjct: 243 NCSIEESMEKFEEVVKSARHMNIPARGYVSCALGCPYEGGITTQKVTEVSKRLYGMGCYE 302
Query: 200 ISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSS 259
ISLGDTIGVGTPG M+ ML +VM+E+P +ALAVHCHDTYGQALAN L ALQMG++VVDS+
Sbjct: 303 ISLGDTIGVGTPGSMRRMLESVMKEIPSSALAVHCHDTYGQALANILTALQMGINVVDSA 362
Query: 260 VAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVA 319
VAGLGGCPYA+GASGN+ATEDL+YML GLG+HTGVNL K++EAG+FIC+A+N+ T+SKVA
Sbjct: 363 VAGLGGCPYAKGASGNVATEDLIYMLHGLGLHTGVNLYKVMEAGDFICKAVNKSTNSKVA 422
Query: 320 QATCK 324
QA+ K
Sbjct: 423 QASFK 427
>emb|CAG09900.1| unnamed protein product [Tetraodon nigroviridis]
Length = 337
Score = 486 bits (1252), Expect = e-135, Method: Composition-based stats.
Identities = 232/334 (69%), Positives = 273/334 (81%), Gaps = 11/334 (3%)
Query: 3 AMRKALPRRLVGLASLR-----------AVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIV 51
A+ + R ++G A + A + TLP++VKIVEVGPRDGLQNEK IV
Sbjct: 4 AVMRVFNRSILGSAMCQQYLAFSSAGKSAAGLRACQTLPEKVKIVEVGPRDGLQNEKTIV 63
Query: 52 STPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLK 111
+ KI LID+LS +GL VIE TSFVSPKWVPQM D EV+KGI + PG++YPVLTPNLK
Sbjct: 64 PSETKIHLIDLLSASGLPVIEATSFVSPKWVPQMADQVEVMKGISRRPGVSYPVLTPNLK 123
Query: 112 GFEAAVAAGAKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCA 171
GF+AAV AGA EV IFGAASELF+KKNINCS++ES QRFD ++KAA+ A + VRGYVSC
Sbjct: 124 GFQAAVQAGASEVAIFGAASELFSKKNINCSVDESLQRFDEVMKAAKEAGVPVRGYVSCV 183
Query: 172 LGCPYEGKISPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALA 231
LGCPYEGK+ P KVA V K+ Y+MGCYEISLGDTIGVGTPG M+DML V +EVP++ALA
Sbjct: 184 LGCPYEGKVEPVKVAHVAKRLYAMGCYEISLGDTIGVGTPGSMRDMLEVVSREVPVSALA 243
Query: 232 VHCHDTYGQALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIH 291
VHCHDTYGQALAN L+ALQMGVSVVDSSVAGLGGCPYAQGASGN+ATED+VYML GLGI
Sbjct: 244 VHCHDTYGQALANILVALQMGVSVVDSSVAGLGGCPYAQGASGNVATEDVVYMLHGLGIQ 303
Query: 292 TGVNLQKLLEAGNFICQALNRKTSSKVAQATCKL 325
TGV+L K+++AG FIC++LNR+T+SKVAQATCKL
Sbjct: 304 TGVDLSKVMDAGAFICRSLNRRTNSKVAQATCKL 337
>ref|NP_001035865.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-like 1 isoform b
[Homo sapiens]
gb|AAH24194.2| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-like 1 [Homo
sapiens]
gb|EAX04444.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-like 1, isoform
CRA_c [Homo sapiens]
Length = 340
Score = 486 bits (1252), Expect = e-135, Method: Composition-based stats.
Identities = 215/302 (71%), Positives = 258/302 (85%)
Query: 20 AVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSP 79
A TS + LP+ VKIVEVGPRDGLQNEK IV T +KI+ I+ LS+ GLSVIE TSFVS
Sbjct: 35 AQETSQLSGLPEFVKIVEVGPRDGLQNEKVIVPTDIKIEFINRLSQTGLSVIEVTSFVSS 94
Query: 80 KWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNI 139
+WVPQM DHTEV+KGI ++PG+ YPVLTPNL+GF AVAAGA E+ +FGAASE F+KKNI
Sbjct: 95 RWVPQMADHTEVMKGIHQYPGVRYPVLTPNLQGFHHAVAAGATEISVFGAASESFSKKNI 154
Query: 140 NCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYE 199
NCSIEES +F+ ++K+A+ NI RGYVSCALGCPYEG I+P KV EV+K+ Y MGCYE
Sbjct: 155 NCSIEESMGKFEEVVKSARHMNIPARGYVSCALGCPYEGSITPQKVTEVSKRLYGMGCYE 214
Query: 200 ISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSS 259
ISLGDTIGVGTPG MK ML +VM+E+P ALAVHCHDTYGQALAN L ALQMG++VVDS+
Sbjct: 215 ISLGDTIGVGTPGSMKRMLESVMKEIPPGALAVHCHDTYGQALANILTALQMGINVVDSA 274
Query: 260 VAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVA 319
V+GLGGCPYA+GASGN+ATEDL+YML GLG++TGVNL K++EAG+FIC+A+N+ T+SKVA
Sbjct: 275 VSGLGGCPYAKGASGNVATEDLIYMLNGLGLNTGVNLYKVMEAGDFICKAVNKTTNSKVA 334
Query: 320 QA 321
QA
Sbjct: 335 QA 336
>gb|EDL77774.1| similar to 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-like 1
(predicted), isoform CRA_a [Rattus norvegicus]
Length = 343
Score = 485 bits (1249), Expect = e-135, Method: Composition-based stats.
Identities = 210/305 (68%), Positives = 256/305 (83%)
Query: 20 AVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSP 79
A S + LP+ VKIVEVGPRDGLQNEK IV T +KI+ I+ LS+ GLSVIE TSFVS
Sbjct: 35 AQEASQLSGLPEYVKIVEVGPRDGLQNEKVIVPTDIKIEFINQLSQTGLSVIEVTSFVSS 94
Query: 80 KWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNI 139
+WVPQM DH EV+ GI ++PG+ YPVL PNL+G + AVAAGA E+ +FGAASE F+KKNI
Sbjct: 95 RWVPQMADHAEVMGGIHQYPGVRYPVLVPNLQGLQHAVAAGATEIAVFGAASESFSKKNI 154
Query: 140 NCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYE 199
NCSIEES RF+ ++ +A+ NI VRGYVSCALGCPYEG I P KV EV+K+ YSMGCYE
Sbjct: 155 NCSIEESMGRFEQVISSARHMNIPVRGYVSCALGCPYEGSIMPQKVTEVSKRLYSMGCYE 214
Query: 200 ISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSS 259
ISLGDT+GVGTPG MK ML +VM+E+P ALAVHCHDTYGQALAN L ALQMG++VVDS+
Sbjct: 215 ISLGDTVGVGTPGSMKTMLESVMKEIPPGALAVHCHDTYGQALANILTALQMGINVVDSA 274
Query: 260 VAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVA 319
V+GLGGCPYA+GASGN+ATEDL+YML G+G++TGV+L K++EAG+FIC+A+N+ T+SKVA
Sbjct: 275 VSGLGGCPYAKGASGNVATEDLIYMLNGMGLNTGVDLHKVMEAGDFICKAVNKTTNSKVA 334
Query: 320 QATCK 324
QA+ K
Sbjct: 335 QASFK 339
>ref|XP_001196745.1| PREDICTED: similar to MGC82338 protein [Strongylocentrotus
purpuratus]
ref|XP_001177727.1| PREDICTED: similar to MGC82338 protein [Strongylocentrotus
purpuratus]
Length = 313
Score = 484 bits (1248), Expect = e-135, Method: Composition-based stats.
Identities = 201/313 (64%), Positives = 251/313 (80%), Gaps = 2/313 (0%)
Query: 15 LASLRAVSTSSMGT--LPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIE 72
+ R V++ + +P+ VKIVEVGPRDGLQNEK +V T KI+LI+ LS+ GL VIE
Sbjct: 1 MVGRRGVASLAGRDAQIPRSVKIVEVGPRDGLQNEKAMVPTETKIELINRLSDTGLKVIE 60
Query: 73 TTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASE 132
TSFVSPKW+PQMGDHT+V+ GI + G++YPVLTPNL+GF++A+ AGA+EV IFGAASE
Sbjct: 61 ATSFVSPKWIPQMGDHTDVMNGITRRGGVSYPVLTPNLQGFKSALEAGAEEVAIFGAASE 120
Query: 133 LFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKF 192
F+KKNINCSI+ES +RF ++L+AA+ AN+ VRGYVSC LGCPYEG + P VA+V K
Sbjct: 121 TFSKKNINCSIDESVERFSSVLEAAREANVKVRGYVSCVLGCPYEGAVQPEAVAKVANKM 180
Query: 193 YSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMG 252
+ MGCYEISLGDTIGVGTPG M+ +L V++ +P +AVHCHDTYGQALAN L ALQMG
Sbjct: 181 FDMGCYEISLGDTIGVGTPGQMQVLLETVLETIPAKHIAVHCHDTYGQALANILAALQMG 240
Query: 253 VSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNR 312
V+VVDSSVAGLGGCPYA+GASGN+ATED+VYML GLGI TG++L+K++ G FI + L R
Sbjct: 241 VTVVDSSVAGLGGCPYAKGASGNVATEDVVYMLNGLGIETGIDLEKIVSVGQFISRELGR 300
Query: 313 KTSSKVAQATCKL 325
+ +SKV A KL
Sbjct: 301 QNTSKVGNAMSKL 313
>ref|XP_001105003.1| PREDICTED: similar to 3-hydroxymethyl-3-methylglutaryl-Coenzyme A
lyase-like 1 [Macaca mulatta]
Length = 444
Score = 484 bits (1246), Expect = e-135, Method: Composition-based stats.
Identities = 218/311 (70%), Positives = 263/311 (84%)
Query: 11 RLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSV 70
L G + TS + LP+ VKIVEVGPRDGLQNEK IV T +KI+ I+ LS+ GLSV
Sbjct: 130 SLAGSVASIHWETSQLSGLPEFVKIVEVGPRDGLQNEKVIVPTDIKIEFINRLSQTGLSV 189
Query: 71 IETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAA 130
IE TSFVS +WVPQM DHTEV+KGI ++PG++YPVLTPNL+GF AVAAGA E+ +FGAA
Sbjct: 190 IEVTSFVSSRWVPQMADHTEVMKGIHQYPGVHYPVLTPNLQGFHRAVAAGATEISVFGAA 249
Query: 131 SELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTK 190
SE F+KKNINCSIEES +F+ ++K+A+ NI RGYVSCALGCPYEG I+P KV EV+K
Sbjct: 250 SESFSKKNINCSIEESMGKFEEVVKSARHMNIPARGYVSCALGCPYEGIITPQKVTEVSK 309
Query: 191 KFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQ 250
+ YSMGCYEISLGDTIGVGTPG MK ML +VM+E+PL ALAVHCHDTYGQALAN L ALQ
Sbjct: 310 RLYSMGCYEISLGDTIGVGTPGSMKRMLESVMKEIPLGALAVHCHDTYGQALANILTALQ 369
Query: 251 MGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQAL 310
MG++VVDS+V+GLGGCPYA+GASGN+ATEDL+YML GLG++TGVNL K++EAG+FIC+A+
Sbjct: 370 MGINVVDSAVSGLGGCPYAKGASGNVATEDLIYMLNGLGLNTGVNLYKVMEAGDFICKAV 429
Query: 311 NRKTSSKVAQA 321
N+ T+SKVAQA
Sbjct: 430 NKTTNSKVAQA 440
>gb|AAL89669.1|AF411956_10 hydroxymethylglutaryl-CoA lyase [Takifugu rubripes]
Length = 325
Score = 484 bits (1246), Expect = e-135, Method: Composition-based stats.
Identities = 233/326 (71%), Positives = 270/326 (82%), Gaps = 2/326 (0%)
Query: 1 MAAM-RKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKL 59
MAA+ + + R + A + S L + VKIVEVGPRDGLQNEK IV KI L
Sbjct: 1 MAALAMRVINRSTLNAAMCQHYLAFSSAKL-QSVKIVEVGPRDGLQNEKTIVPLETKIHL 59
Query: 60 IDMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAA 119
IDMLS +GL VIE TSFVSPKWVPQM D EV+KGI + PG++YPVLTPNLKGF+AAV+A
Sbjct: 60 IDMLSASGLPVIEATSFVSPKWVPQMADQVEVMKGISRKPGVSYPVLTPNLKGFQAAVSA 119
Query: 120 GAKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGK 179
GA EV IFGAASELF+KKNINCS++ES QRFD ++KAA+ A + VRGYVSC LGCPYEGK
Sbjct: 120 GASEVAIFGAASELFSKKNINCSVDESLQRFDEVMKAAKEAGVPVRGYVSCVLGCPYEGK 179
Query: 180 ISPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYG 239
+ PAKVA V K+ YSMGCYEISLGDTIGVGTPG M +ML V +EVP++ALAVHCHDTYG
Sbjct: 180 VEPAKVAHVAKRLYSMGCYEISLGDTIGVGTPGSMCEMLKVVSREVPVSALAVHCHDTYG 239
Query: 240 QALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKL 299
QALAN L+ALQMGVSVVDSSVAGLGGCPYAQGASGN+ATED+VYML GLGI TGV+L K+
Sbjct: 240 QALANILVALQMGVSVVDSSVAGLGGCPYAQGASGNVATEDVVYMLHGLGIQTGVDLSKV 299
Query: 300 LEAGNFICQALNRKTSSKVAQATCKL 325
++AG FIC++LNRK++SKVAQATCKL
Sbjct: 300 MDAGAFICRSLNRKSNSKVAQATCKL 325
>ref|NP_776092.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-like 1 [Mus
musculus]
sp|Q8JZS7|HMGC2_MOUSE Probable 3-hydroxymethyl-3-methylglutaryl-CoA lyase 2
(3-hydroxymethyl-3-methylglutaryl-CoA lyase-like protein
1)
gb|AAH37381.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-like 1 [Mus
musculus]
dbj|BAE24772.1| unnamed protein product [Mus musculus]
gb|EDL26339.1| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-like 1, isoform
CRA_c [Mus musculus]
Length = 343
Score = 483 bits (1245), Expect = e-135, Method: Composition-based stats.
Identities = 211/302 (69%), Positives = 257/302 (85%)
Query: 20 AVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSP 79
A S + LP+ VKIVEVGPRDGLQNEK IV T +KI+LI+ LS+ GLSVIE TSFVS
Sbjct: 35 AQEASQLPGLPEYVKIVEVGPRDGLQNEKVIVPTDIKIELINQLSQTGLSVIEVTSFVSS 94
Query: 80 KWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNI 139
+WVPQM DH EV++GI+++PG+ YPVLTPNL+GF+ AVAAGA E+ +FGAASE F+KKNI
Sbjct: 95 RWVPQMADHAEVMRGIRQYPGVRYPVLTPNLQGFQHAVAAGATEIAVFGAASESFSKKNI 154
Query: 140 NCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYE 199
NCSIEES RF ++ +A+ +I VRGYVSCALGCPYEG I+P KV EV+K+ Y MGCYE
Sbjct: 155 NCSIEESMGRFQEVISSARHMDIPVRGYVSCALGCPYEGSITPQKVTEVSKRLYGMGCYE 214
Query: 200 ISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSS 259
ISLGDTIGVGTPG MK ML +VM+E+P ALAVHCHDTYGQALAN L ALQMG++VVDS+
Sbjct: 215 ISLGDTIGVGTPGSMKMMLESVMKEIPPGALAVHCHDTYGQALANILTALQMGINVVDSA 274
Query: 260 VAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVA 319
V+GLGGCPYA+GASGN+ATEDL+YML G+G++TGV+L K++EAG FIC+A+N+ T+SKVA
Sbjct: 275 VSGLGGCPYAKGASGNVATEDLIYMLNGMGLNTGVDLYKVMEAGEFICKAVNKTTNSKVA 334
Query: 320 QA 321
QA
Sbjct: 335 QA 336
>ref|NP_001103870.1| hypothetical protein LOC571388 [Danio rerio]
sp|A8WG57|HMGC2_DANRE Probable 3-hydroxymethyl-3-methylglutaryl-CoA lyase 2
(3-hydroxymethyl-3-methylglutaryl-CoA lyase-like protein
1)
gb|AAI54588.1| LOC571388 protein [Danio rerio]
Length = 335
Score = 482 bits (1241), Expect = e-134, Method: Composition-based stats.
Identities = 211/300 (70%), Positives = 254/300 (84%)
Query: 24 SSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVP 83
S + LP VKIVEVGPRDGLQNEK IV T VKI+LID+LS+ GL VIE TSFVS KWV
Sbjct: 34 SELPKLPVYVKIVEVGPRDGLQNEKEIVPTEVKIQLIDLLSQTGLPVIEATSFVSSKWVA 93
Query: 84 QMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNINCSI 143
QM DHT VLKGI++ P + YPVLTPN++GF+AAVAAGA EV +FG+ASE F++KNINCSI
Sbjct: 94 QMADHTAVLKGIKRSPDVRYPVLTPNIQGFQAAVAAGANEVAVFGSASETFSRKNINCSI 153
Query: 144 EESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLG 203
EES QRF+ ++ AA+ I VRGYVSCALGCPYEG++ P++V +V K+ + +GCYE+SLG
Sbjct: 154 EESLQRFEQVVSAAKQEGIPVRGYVSCALGCPYEGQVKPSQVTKVAKRLFELGCYEVSLG 213
Query: 204 DTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGL 263
DTIGVGT G M +MLS V+ EVP ALAVHCHDTYGQAL N L+ALQMGVSVVD+SVAGL
Sbjct: 214 DTIGVGTAGSMAEMLSDVLTEVPAGALAVHCHDTYGQALPNILIALQMGVSVVDASVAGL 273
Query: 264 GGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQATC 323
GGCP+A+GASGN++TEDL+YML GLGI TGV+L K++EAG+FIC+ALNRKT+SKV+QAT
Sbjct: 274 GGCPFAKGASGNVSTEDLLYMLHGLGIETGVDLLKVMEAGDFICKALNRKTNSKVSQATR 333
>gb|ABA95738.2| Hydroxymethylglutaryl-CoA lyase, mitochondrial precursor, putative,
expressed [Oryza sativa (japonica cultivar-group)]
gb|EAY82185.1| hypothetical protein OsI_036144 [Oryza sativa (indica
cultivar-group)]
gb|EAZ17365.1| hypothetical protein OsJ_031574 [Oryza sativa (japonica
cultivar-group)]
Length = 387
Score = 481 bits (1240), Expect = e-134, Method: Composition-based stats.
Identities = 189/307 (61%), Positives = 240/307 (78%)
Query: 19 RAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVS 78
RA+ + LP+ VKIVEVGPRDGLQNEKN V T VKI+LI L +GLSV+E TSFVS
Sbjct: 79 RALPRKVLWDLPRFVKIVEVGPRDGLQNEKNTVPTSVKIELIHKLVASGLSVVEATSFVS 138
Query: 79 PKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKN 138
PKWVPQ+ D +V++GI+ P + +PVLTPNL+GFEAAVAAGAKEV +F +ASE F+K N
Sbjct: 139 PKWVPQLADAKDVVEGIKHVPDVRFPVLTPNLRGFEAAVAAGAKEVAVFASASESFSKSN 198
Query: 139 INCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCY 198
+NC+I+ES R+ ++ +A+ I +RGYVSC +GCP EG I P+KVA V K+ Y MGC
Sbjct: 199 LNCTIKESLVRYHDVVTSAKKHGIRIRGYVSCVVGCPVEGTIHPSKVAYVAKELYDMGCS 258
Query: 199 EISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDS 258
EISLGDTIGVGTPG + ML AVM VP+ +AVH HDTYGQALAN L++LQ+G+++VDS
Sbjct: 259 EISLGDTIGVGTPGSVLAMLEAVMSFVPVDKIAVHFHDTYGQALANILVSLQLGINIVDS 318
Query: 259 SVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKV 318
SV+GLGGCPYA+GA+GN+ATED+VYML GLGI T V+L KL++AG++I + L R++ SK
Sbjct: 319 SVSGLGGCPYAKGATGNVATEDVVYMLHGLGIETNVDLNKLMDAGDYISKHLGRQSGSKT 378
Query: 319 AQATCKL 325
A KL
Sbjct: 379 TTALRKL 385
>ref|XP_419903.1| PREDICTED: similar to 3-hydroxymethyl-3-methylglutaryl-Coenzyme A
lyase-like 1 [Gallus gallus]
Length = 420
Score = 481 bits (1239), Expect = e-134, Method: Composition-based stats.
Identities = 220/298 (73%), Positives = 258/298 (86%)
Query: 24 SSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVP 83
S LP+ VKIVEVGPRDGLQNEK IV T KI+LI+ LS+ GL IE TSFVS KWVP
Sbjct: 115 SQASGLPEYVKIVEVGPRDGLQNEKVIVPTDTKIELINRLSKTGLPAIEVTSFVSSKWVP 174
Query: 84 QMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNINCSI 143
QM DH EV++GI++ PG+ YPVLTPNLKGF +A+AAGA EV +FGAASE F+K NINCSI
Sbjct: 175 QMADHKEVMRGIERHPGVQYPVLTPNLKGFHSAIAAGATEVSVFGAASESFSKMNINCSI 234
Query: 144 EESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLG 203
EES ++F+ + K+A++ NI VRGYVSCALGCPYEG I+PAKVAEV+K+ YSMGCYEISLG
Sbjct: 235 EESIEKFEEVAKSARNMNIPVRGYVSCALGCPYEGDITPAKVAEVSKRLYSMGCYEISLG 294
Query: 204 DTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGL 263
DTIGVGTPG MK ML AVM+E+PL+ALAVHCHDTYGQALAN L A+QMGV+VVDSSVAGL
Sbjct: 295 DTIGVGTPGSMKRMLEAVMKEIPLSALAVHCHDTYGQALANILTAIQMGVAVVDSSVAGL 354
Query: 264 GGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQA 321
GGCPYA+GA+GN+ATED++YML GLGI+TGVNL ++EAGNFIC ALN+KT+SKVAQA
Sbjct: 355 GGCPYAKGATGNVATEDVIYMLNGLGINTGVNLYTVMEAGNFICTALNKKTNSKVAQA 412
>ref|NP_001065695.1| Os11g0137200 [Oryza sativa (japonica cultivar-group)]
gb|ABA91354.1| Hydroxymethylglutaryl-CoA lyase, mitochondrial precursor, putative,
expressed [Oryza sativa (japonica cultivar-group)]
dbj|BAF27540.1| Os11g0137200 [Oryza sativa (japonica cultivar-group)]
gb|EAY79856.1| hypothetical protein OsI_033815 [Oryza sativa (indica
cultivar-group)]
gb|EAZ17357.1| hypothetical protein OsJ_031566 [Oryza sativa (japonica
cultivar-group)]
Length = 387
Score = 479 bits (1233), Expect = e-133, Method: Composition-based stats.
Identities = 187/307 (60%), Positives = 239/307 (77%)
Query: 19 RAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVS 78
RA+ + LP+ VKIVEVGPRDGLQNEK+ V VKI+LI L +GLSV+E TSFVS
Sbjct: 79 RALPRKVLWELPRFVKIVEVGPRDGLQNEKSTVPASVKIELIHKLVASGLSVVEATSFVS 138
Query: 79 PKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKN 138
PKWVPQ+ D +VL+GI+ P + +PVLTPNL+GFEAA+AAGAKEV +F +ASE F+K N
Sbjct: 139 PKWVPQLADAKDVLQGIRHVPDVRFPVLTPNLRGFEAALAAGAKEVAVFASASESFSKSN 198
Query: 139 INCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCY 198
+NC+I+ES R+ ++ +A+ + +RGYVSC +GCP EG I P+KVA V K+ Y MGC
Sbjct: 199 LNCTIKESLVRYRDVVTSAKKHGMRIRGYVSCVVGCPVEGTIHPSKVAYVAKELYDMGCS 258
Query: 199 EISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDS 258
EISLGDTIGVGTPG + ML AVM VP+ LAVH HDTYGQALAN L++LQ+G+++VDS
Sbjct: 259 EISLGDTIGVGTPGSILAMLEAVMSFVPVDKLAVHFHDTYGQALANILVSLQLGINIVDS 318
Query: 259 SVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKV 318
SV+GLGGCPYA+GA+GN+ATED+VYML GLGI T V+L KL++AG++I + L R++ SK
Sbjct: 319 SVSGLGGCPYAKGATGNVATEDVVYMLHGLGIETNVDLNKLMDAGDYISKHLGRQSGSKT 378
Query: 319 AQATCKL 325
A KL
Sbjct: 379 TTALRKL 385
>ref|XP_001104722.1| PREDICTED: 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase
(hydroxymethylglutaricaciduria) [Macaca mulatta]
Length = 331
Score = 478 bits (1232), Expect = e-133, Method: Composition-based stats.
Identities = 300/331 (90%), Positives = 302/331 (91%), Gaps = 6/331 (1%)
Query: 1 MAAMRKALPRRLVGLASLRAVSTSS------MGTLPKRVKIVEVGPRDGLQNEKNIVSTP 54
MAAM KALPRRLVGLASLRAVS S GTL RV + V P GL+ NIVSTP
Sbjct: 1 MAAMTKALPRRLVGLASLRAVSAPSRRGGGPAGTLTVRVGSLAVPPEWGLRFLTNIVSTP 60
Query: 55 VKIKLIDMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFE 114
VKIKLIDMLSEAGLSVIE TSFVSPKWVPQM DH EVLKGIQKFPGI YPVL PNLKGFE
Sbjct: 61 VKIKLIDMLSEAGLSVIEATSFVSPKWVPQMADHAEVLKGIQKFPGITYPVLIPNLKGFE 120
Query: 115 AAVAAGAKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGC 174
AAVAAGAKEV IFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSC LGC
Sbjct: 121 AAVAAGAKEVSIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCVLGC 180
Query: 175 PYEGKISPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHC 234
PYEGKISPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVP AALAVHC
Sbjct: 181 PYEGKISPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPPAALAVHC 240
Query: 235 HDTYGQALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGV 294
HDTYGQALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGV
Sbjct: 241 HDTYGQALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGV 300
Query: 295 NLQKLLEAGNFICQALNRKTSSKVAQATCKL 325
NLQKLLEAGNFICQALNRKTSSKVAQATCKL
Sbjct: 301 NLQKLLEAGNFICQALNRKTSSKVAQATCKL 331
>ref|ZP_02912623.1| pyruvate carboxyltransferase [Geobacillus sp. WCH70]
gb|EDT36389.1| pyruvate carboxyltransferase [Geobacillus sp. WCH70]
Length = 299
Score = 476 bits (1227), Expect = e-133, Method: Composition-based stats.
Identities = 152/298 (51%), Positives = 203/298 (68%)
Query: 26 MGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQM 85
M PK+V I EVGPRDGLQNEK +ST KI I+ LS+ GL+ IE TSFV PKW+PQ+
Sbjct: 1 MSKWPKQVTIKEVGPRDGLQNEKTAISTEDKIAWINQLSKTGLTYIEITSFVHPKWIPQL 60
Query: 86 GDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNINCSIEE 145
D EV I++ PG+ Y L PN KG E A+ A EV +F +ASE +KNIN SIEE
Sbjct: 61 SDALEVATRIERAPGVTYAALVPNQKGLEKALTAQVDEVAVFMSASETHNRKNINKSIEE 120
Query: 146 SFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLGDT 205
+F + +++AA+ +VRGYVS GCPYEG +S +V V+++ + MG E+SLGDT
Sbjct: 121 TFPVLEEVVRAAKQEGKTVRGYVSTVFGCPYEGNVSVEQVIRVSERLFDMGIDELSLGDT 180
Query: 206 IGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGG 265
IGV TP ++++L V++ P LA+H HDT G ALAN L++L+MG++ DSS+ GLGG
Sbjct: 181 IGVATPKQVQELLEIVLKRFPKEKLAMHFHDTRGTALANILISLEMGITTFDSSLGGLGG 240
Query: 266 CPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQATC 323
CPYA GASGN+AT+DLVYML G+ I TG+++ +L EA FI + + R SS+ Q
Sbjct: 241 CPYAPGASGNVATDDLVYMLHGMDIATGIDVGRLTEAALFIQEKIGRPLSSRYLQTIS 298
>ref|XP_615612.3| PREDICTED: similar to 3-hydroxymethyl-3-methylglutaryl-Coenzyme A
lyase-like 1 isoform 2 [Bos taurus]
Length = 370
Score = 476 bits (1225), Expect = e-132, Method: Composition-based stats.
Identities = 210/314 (66%), Positives = 260/314 (82%), Gaps = 4/314 (1%)
Query: 8 LPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAG 67
LPR +V + ++ + P+ VKIVEVGPRDGLQNEK IV T +KI+ I+ LS+ G
Sbjct: 57 LPRVVVTV----HWESAQLSGFPEYVKIVEVGPRDGLQNEKVIVPTDIKIEFINQLSQTG 112
Query: 68 LSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIF 127
LSVIE TSFVS +W+PQM DHTEV+KGI ++PGI YPVLTPNL+GF AVAAGA EV +F
Sbjct: 113 LSVIEVTSFVSSRWIPQMADHTEVMKGIHQYPGIRYPVLTPNLQGFHRAVAAGATEVSVF 172
Query: 128 GAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAE 187
GAASE F+KKNINCSIEES ++F+ ++K+A+ NI RGYVSCALGCPYEG I+ KV E
Sbjct: 173 GAASESFSKKNINCSIEESMKKFEEVVKSARHMNIPARGYVSCALGCPYEGNITLQKVTE 232
Query: 188 VTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLM 247
V+K+ Y MGCYEISLGDTIGVGTPG MK ML +VM+E+P ALAVHCHDTYGQA + L+
Sbjct: 233 VSKRLYGMGCYEISLGDTIGVGTPGSMKKMLESVMKEIPPRALAVHCHDTYGQASSGILL 292
Query: 248 ALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFIC 307
+QMG++VVDS+V+GLGGCPYA+GASGN+ATEDL+YML GLG++TGVNL K++EAG+FIC
Sbjct: 293 KIQMGINVVDSAVSGLGGCPYAKGASGNVATEDLIYMLNGLGVNTGVNLYKVMEAGDFIC 352
Query: 308 QALNRKTSSKVAQA 321
+A+N+ T+SKVAQA
Sbjct: 353 KAVNKTTNSKVAQA 366
>dbj|BAE71196.1| putative hydroxymethylglutaryl-CoA lyase [Trifolium pratense]
Length = 433
Score = 474 bits (1222), Expect = e-132, Method: Composition-based stats.
Identities = 195/309 (63%), Positives = 241/309 (77%)
Query: 17 SLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSF 76
++ ++ M +P VKIVEVGPRDGLQNEKN+VST VKI+LI L+ GLSVIE TSF
Sbjct: 118 DMQDMAYKVMKGMPGFVKIVEVGPRDGLQNEKNMVSTDVKIELIHRLASTGLSVIEATSF 177
Query: 77 VSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTK 136
VSPKWVPQ+ D +V+K + GI PVLTPNLKGFEAA+AAGA+EV +F +ASE F+K
Sbjct: 178 VSPKWVPQLADAKDVMKAVHNLGGIRLPVLTPNLKGFEAAIAAGAREVAVFASASESFSK 237
Query: 137 KNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMG 196
NINCSIEES R+ A+ AA++ +I VRGYVSC +GCP EG +SP+KVA V K+ Y MG
Sbjct: 238 SNINCSIEESLARYRAVTSAAKALSIPVRGYVSCVVGCPVEGSVSPSKVAYVAKELYDMG 297
Query: 197 CYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVV 256
C+EISLGDTIGVGTPG + ML AVM VP LAVH HDTYGQ+L+N L++LQMG+S V
Sbjct: 298 CFEISLGDTIGVGTPGTVVPMLLAVMAVVPTEKLAVHFHDTYGQSLSNILVSLQMGISAV 357
Query: 257 DSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSS 316
DSSVAGLGGCPYA+GASGN+ATED+VYML GLG+ T V+++KL+ AG+FI + L R + S
Sbjct: 358 DSSVAGLGGCPYAKGASGNVATEDVVYMLNGLGVKTNVDIEKLMSAGDFIGKHLGRPSGS 417
Query: 317 KVAQATCKL 325
K A A ++
Sbjct: 418 KTAIALSRV 426
>ref|XP_001371535.1| PREDICTED: similar to 3-hydroxymethyl-3-methylglutaryl-Coenzyme A
lyase-like 1 [Monodelphis domestica]
Length = 338
Score = 474 bits (1221), Expect = e-132, Method: Composition-based stats.
Identities = 214/302 (70%), Positives = 261/302 (86%), Gaps = 2/302 (0%)
Query: 20 AVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSP 79
A + + P+ VKIVEVGPRDGLQNEK IV T +KI+ I+ LS+ GLSVIE TSFVS
Sbjct: 35 AQEVTQLSGFPEYVKIVEVGPRDGLQNEKVIVPTDIKIEFINQLSKTGLSVIEVTSFVSS 94
Query: 80 KWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNI 139
KWVPQM D TEV+KGI ++PG+ YPVLT L+GF A+AAGA EV +FGAASE F+KKNI
Sbjct: 95 KWVPQMADQTEVMKGIYQYPGVRYPVLT--LQGFHHAIAAGATEVSVFGAASESFSKKNI 152
Query: 140 NCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYE 199
NCSIEES +RF+A++K+A+ N+ VRGYVSCALGCPYEG+I+P KVAEV+K+ YSMGCYE
Sbjct: 153 NCSIEESMERFEAVVKSARHMNVPVRGYVSCALGCPYEGQIAPEKVAEVSKQLYSMGCYE 212
Query: 200 ISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSS 259
ISLGDTIGVGTPG MK ML +VM+E+P++ALAVHCHDTYGQALAN L ALQMG++VVDS+
Sbjct: 213 ISLGDTIGVGTPGSMKRMLESVMKEIPISALAVHCHDTYGQALANILTALQMGINVVDSA 272
Query: 260 VAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVA 319
V+GLGGCPYA+GASGN+ATEDL+YML G+G++TGVNL K++EAGNFIC+A+N+ T+SKVA
Sbjct: 273 VSGLGGCPYAKGASGNVATEDLIYMLNGIGLNTGVNLYKVMEAGNFICRAINKTTNSKVA 332
Query: 320 QA 321
QA
Sbjct: 333 QA 334
>sp|P35915|HMGCL_CHICK Hydroxymethylglutaryl-CoA lyase (HMG-CoA lyase) (HL)
(3-hydroxy-3-methylglutarate-CoA lyase)
Length = 298
Score = 473 bits (1218), Expect = e-131, Method: Composition-based stats.
Identities = 236/297 (79%), Positives = 269/297 (90%)
Query: 29 LPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQMGDH 88
P+RVK+VEVGPRDGLQNEK++V TPVKI+LIDMLSE GL VIE TSFVSP+WVPQM DH
Sbjct: 2 FPQRVKVVEVGPRDGLQNEKSVVPTPVKIRLIDMLSETGLPVIEATSFVSPRWVPQMADH 61
Query: 89 TEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNINCSIEESFQ 148
EV++GI K PG++YPVLTPNLKGF+AAVAAGAKEV IFGAASELFTKKNINCSIEES +
Sbjct: 62 AEVMQGINKLPGVSYPVLTPNLKGFQAAVAAGAKEVSIFGAASELFTKKNINCSIEESLE 121
Query: 149 RFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLGDTIGV 208
RF ++ AA++A+I VRGYVSC LGCPYEG IS AKVAEV+KK YSMGCYEISLGD IG+
Sbjct: 122 RFSEVMNAARAASIPVRGYVSCVLGCPYEGNISAAKVAEVSKKMYSMGCYEISLGDRIGI 181
Query: 209 GTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGGCPY 268
GTPG MK+ML+AVM+EVP+ ALAVHCHDTYGQALAN L+ALQMGVSVVD+SVAGLGGCPY
Sbjct: 182 GTPGSMKEMLAAVMKEVPVGALAVHCHDTYGQALANILVALQMGVSVVDASVAGLGGCPY 241
Query: 269 AQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQATCKL 325
AQGASGN+ATEDLVYML GLGIHTGV+LQKL++ G FIC ALNR+T+SKV+QA C+L
Sbjct: 242 AQGASGNVATEDLVYMLNGLGIHTGVDLQKLMDTGTFICNALNRRTNSKVSQAACRL 298
>ref|XP_345954.2| PREDICTED: similar to 3-hydroxymethyl-3-methylglutaryl-Coenzyme A
lyase-like 1 [Rattus norvegicus]
ref|XP_001058331.1| PREDICTED: similar to 3-hydroxymethyl-3-methylglutaryl-Coenzyme A
lyase-like 1 [Rattus norvegicus]
Length = 433
Score = 472 bits (1217), Expect = e-131, Method: Composition-based stats.
Identities = 210/305 (68%), Positives = 256/305 (83%)
Query: 20 AVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSP 79
A S + LP+ VKIVEVGPRDGLQNEK IV T +KI+ I+ LS+ GLSVIE TSFVS
Sbjct: 125 AQEASQLSGLPEYVKIVEVGPRDGLQNEKVIVPTDIKIEFINQLSQTGLSVIEVTSFVSS 184
Query: 80 KWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNI 139
+WVPQM DH EV+ GI ++PG+ YPVL PNL+G + AVAAGA E+ +FGAASE F+KKNI
Sbjct: 185 RWVPQMADHAEVMGGIHQYPGVRYPVLVPNLQGLQHAVAAGATEIAVFGAASESFSKKNI 244
Query: 140 NCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYE 199
NCSIEES RF+ ++ +A+ NI VRGYVSCALGCPYEG I P KV EV+K+ YSMGCYE
Sbjct: 245 NCSIEESMGRFEQVISSARHMNIPVRGYVSCALGCPYEGSIMPQKVTEVSKRLYSMGCYE 304
Query: 200 ISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSS 259
ISLGDT+GVGTPG MK ML +VM+E+P ALAVHCHDTYGQALAN L ALQMG++VVDS+
Sbjct: 305 ISLGDTVGVGTPGSMKTMLESVMKEIPPGALAVHCHDTYGQALANILTALQMGINVVDSA 364
Query: 260 VAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVA 319
V+GLGGCPYA+GASGN+ATEDL+YML G+G++TGV+L K++EAG+FIC+A+N+ T+SKVA
Sbjct: 365 VSGLGGCPYAKGASGNVATEDLIYMLNGMGLNTGVDLHKVMEAGDFICKAVNKTTNSKVA 424
Query: 320 QATCK 324
QA+ K
Sbjct: 425 QASFK 429
>ref|XP_001252308.1| PREDICTED: similar to 3-hydroxymethyl-3-methylglutaryl-Coenzyme A
lyase-like 1 isoform 1 [Bos taurus]
Length = 340
Score = 471 bits (1214), Expect = e-131, Method: Composition-based stats.
Identities = 207/302 (68%), Positives = 255/302 (84%)
Query: 20 AVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSP 79
A ++ + P+ VKIVEVGPRDGLQNEK IV T +KI+ I+ LS+ GLSVIE TSFVS
Sbjct: 35 AQESAQLSGFPEYVKIVEVGPRDGLQNEKVIVPTDIKIEFINQLSQTGLSVIEVTSFVSS 94
Query: 80 KWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNI 139
+W+PQM DHTEV+KGI ++PGI YPVLTPNL+GF AVAAGA EV +FGAASE F+KKNI
Sbjct: 95 RWIPQMADHTEVMKGIHQYPGIRYPVLTPNLQGFHRAVAAGATEVSVFGAASESFSKKNI 154
Query: 140 NCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYE 199
NCSIEES ++F+ ++K+A+ NI RGYVSCALGCPYEG I+ KV EV+K+ Y MGCYE
Sbjct: 155 NCSIEESMKKFEEVVKSARHMNIPARGYVSCALGCPYEGNITLQKVTEVSKRLYGMGCYE 214
Query: 200 ISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSS 259
ISLGDTIGVGTPG MK ML +VM+E+P ALAVHCHDTYGQA + L+ +QMG++VVDS+
Sbjct: 215 ISLGDTIGVGTPGSMKKMLESVMKEIPPRALAVHCHDTYGQASSGILLKIQMGINVVDSA 274
Query: 260 VAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVA 319
V+GLGGCPYA+GASGN+ATEDL+YML GLG++TGVNL K++EAG+FIC+A+N+ T+SKVA
Sbjct: 275 VSGLGGCPYAKGASGNVATEDLIYMLNGLGVNTGVNLYKVMEAGDFICKAVNKTTNSKVA 334
Query: 320 QA 321
QA
Sbjct: 335 QA 336
>ref|NP_001066093.1| Os12g0134000 [Oryza sativa (japonica cultivar-group)]
gb|ABG21875.1| Hydroxymethylglutaryl-CoA lyase, mitochondrial precursor, putative,
expressed [Oryza sativa (japonica cultivar-group)]
dbj|BAF29112.1| Os12g0134000 [Oryza sativa (japonica cultivar-group)]
Length = 377
Score = 471 bits (1213), Expect = e-131, Method: Composition-based stats.
Identities = 188/314 (59%), Positives = 242/314 (77%), Gaps = 4/314 (1%)
Query: 12 LVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVI 71
+ +++ V + LP+ VKIVEVGPRDGLQNEKN V T VKI+LI L +GLSV+
Sbjct: 66 SIMTVAMQHV----LWDLPRFVKIVEVGPRDGLQNEKNTVPTSVKIELIHKLVASGLSVV 121
Query: 72 ETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAAS 131
E TSFVSPKWVPQ+ D +V++GI+ P + +PVLTPNL+GFEAAVAAGAKEV +F +AS
Sbjct: 122 EATSFVSPKWVPQLADAKDVVEGIKHVPDVRFPVLTPNLRGFEAAVAAGAKEVAVFASAS 181
Query: 132 ELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKK 191
E F+K N+NC+I+ES R+ ++ +A+ I +RGYVSC +GCP EG I P+KVA V K+
Sbjct: 182 ESFSKSNLNCTIKESLVRYHDVVTSAKKHGIRIRGYVSCVVGCPVEGTIHPSKVAYVAKE 241
Query: 192 FYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQM 251
Y MGC EISLGDTIGVGTPG + ML AVM VP+ +AVH HDTYGQALAN L++LQ+
Sbjct: 242 LYDMGCSEISLGDTIGVGTPGSVLAMLEAVMSFVPVDKIAVHFHDTYGQALANILVSLQL 301
Query: 252 GVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALN 311
G+++VDSSV+GLGGCPYA+GA+GN+ATED+VYML GLGI T V+L KL++AG++I + L
Sbjct: 302 GINIVDSSVSGLGGCPYAKGATGNVATEDVVYMLHGLGIETNVDLNKLMDAGDYISKHLG 361
Query: 312 RKTSSKVAQATCKL 325
R++ SK A KL
Sbjct: 362 RQSGSKTTTALRKL 375
>emb|CAO67270.1| unnamed protein product [Vitis vinifera]
Length = 432
Score = 470 bits (1210), Expect = e-131, Method: Composition-based stats.
Identities = 193/307 (62%), Positives = 234/307 (76%)
Query: 19 RAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVS 78
R ++ +G +PK VKIVEVGPRDGLQNEKNIV T VK++LI L GL V+E TSFVS
Sbjct: 119 RGMANKFLGGIPKFVKIVEVGPRDGLQNEKNIVPTAVKVELIHRLVSCGLPVVEATSFVS 178
Query: 79 PKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKN 138
PKWVPQ+ D +V++ ++ G PVLTPNLKGFEAA+AAGAKEV IF +ASE F+K N
Sbjct: 179 PKWVPQLADAKDVMEAVRNLEGARLPVLTPNLKGFEAAIAAGAKEVAIFASASESFSKSN 238
Query: 139 INCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCY 198
INCSIEES R+ A+ AA+ +I VRGYVSC +GCP EG ISP+KVA V K+ Y MGC+
Sbjct: 239 INCSIEESLTRYRAVALAAKKLSIPVRGYVSCVVGCPVEGAISPSKVAYVAKELYDMGCF 298
Query: 199 EISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDS 258
EISLGDTIGV TPG + ML AVM VP+ LAVH HDTYGQ+L N L++LQMG+S +DS
Sbjct: 299 EISLGDTIGVATPGAIVPMLEAVMAVVPVEKLAVHFHDTYGQSLPNILLSLQMGISTIDS 358
Query: 259 SVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKV 318
SVAGLGGCPYA+GASGN+ATED+VYML GLG+ T V+L KL+ G+FI L R + SK
Sbjct: 359 SVAGLGGCPYAKGASGNVATEDVVYMLNGLGVKTNVDLGKLMLVGDFISNRLGRPSGSKT 418
Query: 319 AQATCKL 325
A A ++
Sbjct: 419 AIALSRV 425
>ref|YP_001502656.1| pyruvate carboxyltransferase [Shewanella pealeana ATCC 700345]
gb|ABV88121.1| pyruvate carboxyltransferase [Shewanella pealeana ATCC 700345]
Length = 301
Score = 467 bits (1204), Expect = e-130, Method: Composition-based stats.
Identities = 191/297 (64%), Positives = 226/297 (76%), Gaps = 1/297 (0%)
Query: 27 GTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQMG 86
PK+V I EVG RDGLQNEK V+T KI LI+ L+ AG+ IE SFVSPKWVPQM
Sbjct: 5 SPYPKKVSIFEVGARDGLQNEK-PVTTQDKIILIEDLAAAGIKRIEAASFVSPKWVPQMA 63
Query: 87 DHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNINCSIEES 146
D +VL GI + G+ Y LTPNLKG E A+ AGA EV IFGAASE F++KNINCSIEES
Sbjct: 64 DSADVLHGITRKTGVTYSALTPNLKGLELALDAGADEVAIFGAASESFSQKNINCSIEES 123
Query: 147 FQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLGDTI 206
+RF +++ A++ NI VRGYVSC LGCPYEG I+ ++VA V++ Y MGCYEISLGDTI
Sbjct: 124 IERFIPVMEQAKARNIPVRGYVSCTLGCPYEGDIAVSEVARVSELLYKMGCYEISLGDTI 183
Query: 207 GVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGGC 266
GVGTP + M+ AV + VP+ LA+H HDTYGQALAN L L+ GVSV+DSSVAGLGGC
Sbjct: 184 GVGTPLNARRMIEAVAELVPVEKLALHFHDTYGQALANILACLETGVSVIDSSVAGLGGC 243
Query: 267 PYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQATC 323
PYA+GASGNLATEDLVYML GLGI TG++L KL+ AGN I QAL R + SKVA+A
Sbjct: 244 PYAKGASGNLATEDLVYMLHGLGIETGIDLTKLVNAGNKISQALGRPSGSKVARALS 300
>ref|NP_565629.1| hydroxymethylglutaryl-CoA lyase, putative /
3-hydroxy-3-methylglutarate-CoA lyase, putative /
HMG-CoA lyase, putative [Arabidopsis thaliana]
gb|AAG42010.1|AF327420_1 putative hydroxymethylglutaryl-CoA lyase [Arabidopsis thaliana]
gb|AAK15568.1|AF349521_1 putative hydroxymethylglutaryl-CoA lyase [Arabidopsis thaliana]
gb|AAC32247.2| putative hydroxymethylglutaryl-CoA lyase [Arabidopsis thaliana]
Length = 468
Score = 467 bits (1204), Expect = e-130, Method: Composition-based stats.
Identities = 188/297 (63%), Positives = 228/297 (76%)
Query: 28 TLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQMGD 87
+PK VKIVEVGPRDGLQNEKNIV T VK++LI L +GL V+E TSFVSPKWVPQ+ D
Sbjct: 163 GIPKFVKIVEVGPRDGLQNEKNIVPTSVKVELIQRLVSSGLPVVEATSFVSPKWVPQLAD 222
Query: 88 HTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNINCSIEESF 147
+V+ + G PVLTPNLKGF+AAV+AGAKEV IF +ASE F+ NINC+IEES
Sbjct: 223 AKDVMDAVNTLDGARLPVLTPNLKGFQAAVSAGAKEVAIFASASESFSLSNINCTIEESL 282
Query: 148 QRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLGDTIG 207
R+ + AA+ ++ VRGYVSC +GCP EG + P+KVA V K+ Y MGC+EISLGDTIG
Sbjct: 283 LRYRVVATAAKEHSVPVRGYVSCVVGCPVEGPVLPSKVAYVVKELYDMGCFEISLGDTIG 342
Query: 208 VGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGGCP 267
+GTPG + ML AVM VP LAVH HDTYGQALAN L++LQMG+S+VDSS+AGLGGCP
Sbjct: 343 IGTPGSVVPMLEAVMAVVPADKLAVHFHDTYGQALANILVSLQMGISIVDSSIAGLGGCP 402
Query: 268 YAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQATCK 324
YA+GASGN+ATED+VYML GLG+HT V+L KL+ AG+FI + L R SK A A +
Sbjct: 403 YAKGASGNVATEDVVYMLNGLGVHTNVDLGKLIAAGDFISKHLGRPNGSKAAVALNR 459
>ref|NP_609089.1| CG10399 CG10399-PA [Drosophila melanogaster]
gb|AAF52467.2| CG10399-PA [Drosophila melanogaster]
gb|ABV82423.1| TA01441p [Drosophila melanogaster]
Length = 323
Score = 466 bits (1201), Expect = e-130, Method: Composition-based stats.
Identities = 191/318 (60%), Positives = 239/318 (75%), Gaps = 4/318 (1%)
Query: 4 MRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDML 63
M A R ++ L + R TS+ +V+IVEVGPRDGLQNE ++ KI+LI+ L
Sbjct: 1 MISAPIRSILALTAKRTAVTSAAN----QVRIVEVGPRDGLQNEPKLLPAATKIELINQL 56
Query: 64 SEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKE 123
SE GL IE TSFVS KWVPQMGD+ EVLKGI+K GI+YPVLTPNLKGFE+A+ AGA+E
Sbjct: 57 SETGLRTIEATSFVSAKWVPQMGDNAEVLKGIRKVTGISYPVLTPNLKGFESALEAGAEE 116
Query: 124 VVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPA 183
V +FGAAS+ F+ KN+NC+ E+ +RF +LKAAQ + VRGYVS +GCPYEG ++P+
Sbjct: 117 VAVFGAASDAFSLKNVNCTAAEAIERFKPVLKAAQKHGVRVRGYVSTVVGCPYEGAVAPS 176
Query: 184 KVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALA 243
V +V + Y MGCYEISLGDTIGVGTPG M+ ML V + VP LAVHCHDTYGQAL+
Sbjct: 177 AVVKVVEALYQMGCYEISLGDTIGVGTPGTMRRMLDEVTKVVPAKDLAVHCHDTYGQALS 236
Query: 244 NTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAG 303
N L++L G+ VVDSSV+GLGGCPYA+GASGN ATED+VY+L G+G+ TGVNL KL++ G
Sbjct: 237 NILVSLDYGIRVVDSSVSGLGGCPYAKGASGNAATEDVVYLLHGMGLDTGVNLDKLIQVG 296
Query: 304 NFICQALNRKTSSKVAQA 321
+IC L R + SKV +A
Sbjct: 297 RYICTELGRTSESKVNRA 314
Database: All non-redundant GenBank CDS
translations+PDB+SwissProt+PIR+PRF excluding environmental samples
from WGS projects
Posted date: May 23, 2008 5:56 PM
Number of letters in database: 883,778,997
Number of sequences in database: 2,617,685
Database: /host/Blast/data/nr_perl/nr.01
Posted date: May 23, 2008 5:54 PM
Number of letters in database: 976,759,346
Number of sequences in database: 2,761,413
Database: /host/Blast/data/nr_perl/nr.02
Posted date: May 23, 2008 5:48 PM
Number of letters in database: 374,670,760
Number of sequences in database: 1,165,270
Database: /host/Blast/data/nr_perl/nr.03
Posted date: Apr 28, 2009 5:40 PM
Number of letters in database: 114,943,120
Number of sequences in database: 354,819
Lambda K H
0.314 0.185 0.566
Lambda K H
0.267 0.0565 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 5,838,756,059
Number of Sequences: 6899187
Number of extensions: 356103934
Number of successful extensions: 1035695
Number of sequences better than 10.0: 300
Number of HSP's better than 10.0 without gapping: 8272
Number of HSP's successfully gapped in prelim test: 3505
Number of HSP's that attempted gapping in prelim test: 1006097
Number of HSP's gapped (non-prelim): 14674
length of query: 325
length of database: 2,350,152,223
effective HSP length: 134
effective length of query: 191
effective length of database: 1,425,661,165
effective search space: 272301282515
effective search space used: 272301282515
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.0 bits)
S2: 80 (35.0 bits)