BLASTP 2.2.17 [Aug-26-2007]
Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Reference for composition-based statistics:
Schäffer, Alejandro A., L. Aravind, Thomas L. Madden,
Schaffer, Alejandro A., L. Aravind, Thomas L. Madden,
Sergei Shavirin, John L. Spouge, Yuri I. Wolf,
Eugene V. Koonin, and Stephen F. Altschul (2001),
"Improving the accuracy of PSI-BLAST protein database searches with
composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005.
Query= ENSG00000119912__[Homo_sapiens]
(1019 letters)
Database: All non-redundant GenBank CDS
translations+PDB+SwissProt+PIR+PRF excluding environmental samples
from WGS projects
6,899,187 sequences; 2,350,152,223 total letters
Searching..................................................done
Results from round 1
Score E
Sequences producing significant alignments: (bits) Value
ref|NP_004960.2| insulysin [Homo sapiens] >gi|55959215|emb|... 2081 0.0
ref|XP_507922.2| PREDICTED: insulysin isoform 4 [Pan troglo... 2079 0.0
ref|XP_001501085.1| PREDICTED: similar to insulin-degrading... 2075 0.0
ref|XP_001090249.1| PREDICTED: insulysin isoform 3 [Macaca ... 2071 0.0
ref|NP_001069317.1| insulin-degrading enzyme [Bos taurus] >... 2058 0.0
sp|P14735|IDE_HUMAN Insulin-degrading enzyme (Insulysin) (I... 2052 0.0
ref|XP_001146582.1| PREDICTED: insulysin isoform 3 [Pan tro... 2038 0.0
ref|NP_037291.1| insulin degrading enzyme [Rattus norvegicu... 1998 0.0
ref|NP_112419.2| insulin degrading enzyme [Mus musculus] >g... 1996 0.0
pdb|2G47|A Chain A, Crystal Structure Of Human Insulin-Degr... 1994 0.0
ref|XP_001146520.1| PREDICTED: insulysin isoform 2 [Pan tro... 1994 0.0
pdb|2JG4|A Chain A, Substrate-Free Ide Structure In Its Clo... 1994 0.0
sp|Q9JHR7|IDE_MOUSE Insulin-degrading enzyme (Insulysin) (I... 1988 0.0
ref|XP_001090137.1| PREDICTED: insulysin isoform 2 [Macaca ... 1988 0.0
ref|XP_534963.2| PREDICTED: similar to Insulin-degrading en... 1987 0.0
ref|XP_001506502.1| PREDICTED: similar to insulin-degrading... 1954 0.0
gb|EDL41785.1| insulin degrading enzyme [Mus musculus] 1933 0.0
pdb|2WBY|A Chain A, Crystal Structure Of Human Insulin-Degr... 1932 0.0
dbj|BAF62161.1| insulin-degrading enzyme [Danio rerio] 1833 0.0
ref|NP_001082994.1| insulin-degrading enzyme [Danio rerio] ... 1831 0.0
ref|XP_001146439.1| PREDICTED: insulysin isoform 1 [Pan tro... 1742 0.0
ref|XP_001090017.1| PREDICTED: insulysin isoform 1 [Macaca ... 1736 0.0
dbj|BAD92441.1| insulysin variant [Homo sapiens] 1199 0.0
ref|XP_001629798.1| predicted protein [Nematostella vectens... 1184 0.0
gb|EAW50092.1| insulin-degrading enzyme, isoform CRA_b [Hom... 1114 0.0
ref|XP_971897.1| PREDICTED: similar to Insulin-degrading en... 1099 0.0
ref|XP_001603463.1| PREDICTED: similar to metalloprotease [... 1088 0.0
ref|XP_421686.2| PREDICTED: similar to insulin-degrading en... 1006 0.0
ref|XP_001847597.1| metalloprotease [Culex pipiens quinquef... 1001 0.0
ref|XP_001661876.1| metalloprotease [Aedes aegypti] >gi|108... 997 0.0
emb|CAF89725.1| unnamed protein product [Tetraodon nigrovir... 977 0.0
ref|XP_001194830.1| PREDICTED: similar to Insulin-degrading... 929 0.0
gb|AAO74689.1| RE17458p [Drosophila melanogaster] 925 0.0
ref|NP_524182.2| Insulin degrading metalloproteinase CG5517... 924 0.0
ref|XP_795975.2| PREDICTED: similar to Insulin-degrading en... 922 0.0
sp|P22817|IDE_DROME Insulin-degrading enzyme (Insulysin) (I... 920 0.0
ref|XP_311589.4| AGAP010351-PA [Anopheles gambiae str. PEST... 914 0.0
gb|AAA28439.1| insulin-degrading enzyme 911 0.0
ref|XP_001354132.1| GA18943-PA [Drosophila pseudoobscura] >... 909 0.0
ref|XP_001896776.1| insulin-degrading enzyme [Brugia malayi... 827 0.0
ref|XP_001649937.1| metalloprotease [Aedes aegypti] >gi|108... 808 0.0
ref|XP_001674236.1| Hypothetical protein CBG09322 [Caenorha... 778 0.0
ref|XP_505854.1| hypothetical protein [Yarrowia lipolytica]... 762 0.0
ref|NP_741542.1| F44E7.4b [Caenorhabditis elegans] >gi|2128... 760 0.0
ref|XP_759404.1| hypothetical protein UM03257.1 [Ustilago m... 757 0.0
ref|NP_741543.1| F44E7.4a [Caenorhabditis elegans] >gi|2291... 751 0.0
ref|NP_504514.2| F44E7.4c [Caenorhabditis elegans] >gi|2737... 750 0.0
ref|XP_001731164.1| hypothetical protein MGL_1347 [Malassez... 748 0.0
ref|NP_001023928.1| F44E7.4d [Caenorhabditis elegans] >gi|5... 743 0.0
ref|NP_507226.2| Y70C5C.1 [Caenorhabditis elegans] >gi|5808... 730 0.0
ref|XP_748141.1| a-pheromone processing metallopeptidase St... 729 0.0
gb|EDP51051.1| a-pheromone processing metallopeptidase Ste2... 729 0.0
ref|XP_001266332.1| a-pheromone processing metallopeptidase... 725 0.0
ref|XP_001770543.1| predicted protein [Physcomitrella paten... 722 0.0
ref|XP_681313.1| hypothetical protein AN8044.2 [Aspergillus... 712 0.0
ref|XP_001761886.1| predicted protein [Physcomitrella paten... 711 0.0
ref|XP_001276340.1| a-pheromone processing metallopeptidase... 705 0.0
gb|EDN59292.1| metalloprotease [Saccharomyces cerevisiae YJ... 704 0.0
ref|NP_013493.2| Metalloprotease involved, with homolog Axl... 702 0.0
ref|XP_956166.1| hypothetical protein NCU00481 [Neurospora ... 698 0.0
gb|ABH09708.1| STE23-like protein [Penicillium marneffei] 698 0.0
ref|XP_001397499.1| hypothetical protein An16g01860 [Asperg... 694 0.0
ref|XP_001242515.1| hypothetical protein CIMG_06411 [Coccid... 694 0.0
emb|CAO23586.1| unnamed protein product [Vitis vinifera] 694 0.0
ref|NP_001060044.1| Os07g0570300 [Oryza sativa (japonica cu... 693 0.0
ref|XP_001820380.1| hypothetical protein [Aspergillus oryza... 689 0.0
emb|CAC67408.1| insulin degrading enzyme [Solanum lycopersi... 688 0.0
dbj|BAE98754.1| putative zinc protease [Arabidopsis thaliana] 687 0.0
ref|NP_181710.1| peptidase M16 family protein / insulinase ... 686 0.0
gb|EDU43925.1| insulin-degrading enzyme [Pyrenophora tritic... 684 0.0
ref|XP_001763915.1| predicted protein [Physcomitrella paten... 677 0.0
ref|NP_001044429.1| Os01g0778800 [Oryza sativa (japonica cu... 675 0.0
ref|XP_360292.2| hypothetical protein MGG_13149 [Magnaporth... 673 0.0
gb|EEH46323.1| insulin-degrading enzyme [Paracoccidioides b... 672 0.0
ref|NP_504532.1| C02G6.1 [Caenorhabditis elegans] >gi|12801... 672 0.0
ref|XP_387087.1| hypothetical protein FG06911.1 [Gibberella... 672 0.0
dbj|BAC79699.1| putative insulin degrading enzyme [Oryza sa... 669 0.0
ref|XP_454175.1| unnamed protein product [Kluyveromyces lac... 666 0.0
ref|XP_773498.1| hypothetical protein CNBI1120 [Cryptococcu... 666 0.0
ref|XP_568105.1| insulin degrading enzyme [Cryptococcus neo... 666 0.0
ref|XP_001801272.1| hypothetical protein SNOG_11020 [Phaeos... 664 0.0
ref|XP_001646584.1| hypothetical protein Kpol_1055p83 [Vand... 664 0.0
emb|CAO23585.1| unnamed protein product [Vitis vinifera] 663 0.0
gb|EAZ04397.1| hypothetical protein OsI_025629 [Oryza sativ... 660 0.0
gb|EAZ40359.1| hypothetical protein OsJ_023842 [Oryza sativ... 660 0.0
ref|XP_001218442.1| hypothetical protein ATEG_09820 [Asperg... 655 0.0
emb|CAB66104.1| protease-like protein [Arabidopsis thaliana] 652 0.0
ref|XP_001908020.1| unnamed protein product [Podospora anse... 650 0.0
gb|EAZ04398.1| hypothetical protein OsI_025630 [Oryza sativ... 647 0.0
ref|XP_001775609.1| predicted protein [Physcomitrella paten... 646 0.0
ref|NP_984913.1| AER053Cp [Ashbya gossypii ATCC 10895] >gi|... 645 0.0
ref|NP_593966.1| metallopeptidase [Schizosaccharomyces pomb... 644 0.0
ref|XP_001543275.1| conserved hypothetical protein [Ajellom... 636 e-180
ref|XP_447076.1| unnamed protein product [Candida glabrata]... 634 e-179
ref|XP_001590112.1| hypothetical protein SS1G_08876 [Sclero... 633 e-179
gb|EAY76035.1| hypothetical protein OsI_003882 [Oryza sativ... 630 e-178
ref|XP_001391726.1| hypothetical protein An07g06490 [Asperg... 627 e-177
ref|XP_001383768.2| hypothetical protein PICST_56651 [Pichi... 620 e-175
dbj|BAD52843.1| putative insulin degrading enzyme [Oryza sa... 618 e-175
ref|NP_504531.2| C02G6.2 [Caenorhabditis elegans] >gi|33620... 617 e-174
ref|XP_719241.1| a-factor pheromone maturation protease [Ca... 616 e-174
ref|NP_001118852.1| peptidase M16 family protein / insulina... 613 e-173
ref|XP_456547.1| hypothetical protein DEHA0A05214g [Debaryo... 611 e-173
gb|EAZ40360.1| hypothetical protein OsJ_023843 [Oryza sativ... 607 e-171
ref|XP_001486793.1| hypothetical protein PGUG_00170 [Pichia... 605 e-171
ref|XP_001524140.1| conserved hypothetical protein [Loddero... 600 e-169
gb|EEH33611.1| A-factor-processing enzyme [Paracoccidioides... 595 e-168
ref|XP_001874916.1| predicted protein [Laccaria bicolor S23... 591 e-166
dbj|BAF01167.1| hypothetical protein [Arabidopsis thaliana] 579 e-163
ref|NP_172173.2| metalloendopeptidase [Arabidopsis thaliana] 579 e-163
ref|XP_396981.2| PREDICTED: similar to Insulin-degrading en... 578 e-163
gb|EAY89915.1| hypothetical protein OsI_011148 [Oryza sativ... 577 e-162
gb|EAZ26839.1| hypothetical protein OsJ_010322 [Oryza sativ... 577 e-162
ref|NP_001050040.1| Os03g0336300 [Oryza sativa (japonica cu... 577 e-162
ref|XP_001833053.1| hypothetical protein CC1G_01115 [Coprin... 569 e-160
ref|NP_567049.2| peptidase M16 family protein / insulinase ... 565 e-159
ref|XP_001760214.1| predicted protein [Physcomitrella paten... 565 e-159
emb|CAO21314.1| unnamed protein product [Vitis vinifera] 556 e-156
ref|XP_001031077.1| Insulysin, Insulin-degrading enzyme [Te... 556 e-156
gb|EAY76045.1| hypothetical protein OsI_003892 [Oryza sativ... 554 e-155
ref|ZP_01101893.1| protease III precursor [gamma proteobact... 548 e-154
ref|XP_001434792.1| hypothetical protein GSPATT00006701001 ... 546 e-153
gb|EAZ13744.1| hypothetical protein OsJ_003569 [Oryza sativ... 541 e-152
ref|NP_495575.2| C28F5.4 [Caenorhabditis elegans] >gi|15038... 541 e-151
ref|YP_436112.1| Secreted/periplasmic Zn-dependent peptidas... 541 e-151
ref|XP_001105075.1| PREDICTED: similar to nardilysin (N-arg... 540 e-151
ref|XP_513403.2| PREDICTED: nardilysin (N-arginine dibasic ... 540 e-151
ref|NP_002516.2| nardilysin (N-arginine dibasic convertase)... 540 e-151
ref|XP_001140946.1| PREDICTED: nardilysin (N-arginine dibas... 539 e-151
sp|O43847|NRDC_HUMAN Nardilysin precursor (N-arginine dibas... 539 e-151
ref|NP_001095132.1| nardilysin (N-arginine dibasic converta... 539 e-151
ref|XP_001140801.1| PREDICTED: nardilysin (N-arginine dibas... 539 e-151
emb|CAA63694.1| NRD2 convertase [Homo sapiens] 538 e-150
emb|CAA63698.1| NRD1 convertase [Homo sapiens] 537 e-150
ref|XP_001140731.1| PREDICTED: nardilysin (N-arginine dibas... 537 e-150
gb|AAH26832.1| Nardilysin, N-arginine dibasic convertase, N... 537 e-150
gb|EAX06808.1| nardilysin (N-arginine dibasic convertase), ... 537 e-150
ref|NP_666262.2| nardilysin, N-arginine dibasic convertase,... 537 e-150
ref|XP_001695185.1| insulinase-like metalloprotease [Chlamy... 536 e-150
gb|AAC39597.1| NRD convertase [Homo sapiens] 536 e-150
ref|ZP_01616823.1| Secreted/periplasmic Zn-dependent peptid... 536 e-150
gb|AAF63132.1|AC011001_2 Putative N-arginine dibasic conver... 536 e-150
ref|NP_037125.1| n-arginine dibasic convertase 1 [Rattus no... 536 e-150
gb|EDL90380.1| nardilysin, N-arginine dibasic convertase 1 ... 536 e-150
emb|CAM16904.1| nardilysin, N-arginine dibasic convertase, ... 536 e-150
emb|CAA63696.1| NRD2 convertase [Rattus sp.] 535 e-150
gb|EAX06804.1| nardilysin (N-arginine dibasic convertase), ... 535 e-150
ref|XP_859649.1| PREDICTED: similar to Nardilysin precursor... 535 e-150
gb|EAX06805.1| nardilysin (N-arginine dibasic convertase), ... 535 e-149
sp|Q5R4H6|NRDC_PONPY Nardilysin precursor (N-arginine dibas... 535 e-149
gb|AAQ63406.1| nardilysin isoform [Homo sapiens] 534 e-149
ref|XP_532578.2| PREDICTED: similar to nardilysin (N-argini... 534 e-149
gb|AAH23786.1| Nrd1 protein [Mus musculus] 533 e-149
ref|XP_001491329.1| PREDICTED: similar to nardilysin (N-arg... 532 e-149
ref|XP_001491380.1| PREDICTED: similar to nardilysin (N-arg... 531 e-148
ref|XP_001491355.1| PREDICTED: similar to nardilysin (N-arg... 530 e-148
ref|XP_001491299.1| PREDICTED: similar to nardilysin (N-arg... 529 e-148
ref|XP_001251166.1| PREDICTED: similar to NRD1 protein isof... 526 e-147
ref|XP_001251122.1| PREDICTED: similar to NRD1 protein isof... 526 e-147
ref|ZP_01235782.1| putative peptidase, insulinase family pr... 525 e-146
ref|ZP_01159983.1| putative peptidase, insulinase family pr... 524 e-146
ref|XP_588554.3| PREDICTED: similar to NRD1 protein isoform... 524 e-146
ref|XP_001251077.1| PREDICTED: similar to NRD1 protein isof... 524 e-146
ref|XP_694205.1| PREDICTED: similar to Nardilysin, N-argini... 523 e-146
ref|XP_001024628.2| Insulysin, Insulin-degrading enzyme [Te... 522 e-146
ref|ZP_01135442.1| zinc metallopeptidase, M16 family protei... 522 e-146
ref|ZP_01222787.1| putative peptidase, insulinase family pr... 520 e-145
ref|XP_001362262.1| PREDICTED: similar to nardilysin (N-arg... 519 e-145
ref|ZP_02135987.1| insulin-degrading enzyme [Vibrio fischer... 519 e-145
ref|YP_205192.1| protease III [Vibrio fischeri ES114] >gi|5... 519 e-145
ref|XP_001362352.1| PREDICTED: similar to nardilysin (N-arg... 518 e-145
ref|NP_001038180.2| hypothetical protein LOC557565 [Danio r... 518 e-144
ref|YP_129176.1| putative peptidase, insulinase family [Pho... 517 e-144
ref|XP_001449286.1| hypothetical protein GSPATT00016702001 ... 517 e-144
ref|YP_001141698.1| insulinase [Aeromonas salmonicida subsp... 515 e-144
ref|ZP_01168295.1| zinc metallopeptidase, M16 family [Ocean... 509 e-142
ref|YP_856528.1| peptidase, insulinase family [Aeromonas hy... 506 e-141
ref|NP_001026455.1| nardilysin (N-arginine dibasic converta... 504 e-140
ref|YP_959771.1| peptidase M16 domain protein [Marinobacter... 503 e-140
ref|YP_001674877.1| peptidase M16 domain protein [Shewanell... 502 e-140
ref|NP_798585.1| peptidase, insulinase family [Vibrio parah... 501 e-139
ref|ZP_02157408.1| peptidase, M16 family protein [Shewanell... 499 e-139
gb|EDN12518.1| peptidase, insulinase family [Vibrio cholera... 499 e-139
gb|EDN15048.1| peptidase, insulinase family [Vibrio cholera... 499 e-139
ref|ZP_01223918.1| peptidase, insulinase family protein [ma... 499 e-139
ref|XP_001030234.1| Insulysin, Insulin-degrading enzyme [Te... 498 e-138
ref|ZP_01948940.1| peptidase, insulinase family [Vibrio cho... 498 e-138
emb|CAI13669.1| insulin-degrading enzyme [Homo sapiens] 498 e-138
ref|ZP_01978745.1| peptidase, insulinase family [Vibrio cho... 497 e-138
ref|YP_268860.1| zinc metallopeptidase, M16 family [Colwell... 497 e-138
ref|ZP_01956551.1| peptidase, insulinase family [Vibrio cho... 497 e-138
ref|NP_231704.1| peptidase, insulinase family [Vibrio chole... 496 e-138
ref|ZP_01736964.1| Secreted/periplasmic Zn-dependent peptid... 496 e-138
ref|ZP_01482660.1| hypothetical protein VchoR_02001413 [Vib... 496 e-138
ref|YP_733547.1| Insulysin [Shewanella sp. MR-4] >gi|113884... 495 e-138
gb|EAZ49727.1| peptidase, insulinase family [Vibrio cholera... 494 e-137
ref|ZP_01478796.1| hypothetical protein VchoM_02002058 [Vib... 494 e-137
ref|YP_001183975.1| peptidase M16 domain protein [Shewanell... 494 e-137
ref|NP_718646.1| peptidase, M16 family [Shewanella oneidens... 494 e-137
ref|YP_962945.1| peptidase M16 domain protein [Shewanella s... 493 e-137
ref|ZP_01706404.1| peptidase M16-like [Shewanella putrefaci... 493 e-137
ref|ZP_01981574.1| peptidase, insulinase family [Vibrio cho... 493 e-137
ref|ZP_01892098.1| Secreted/periplasmic Zn-dependent peptid... 493 e-137
ref|YP_737533.1| peptidase M16 domain protein [Shewanella s... 492 e-137
ref|YP_562541.1| peptidase M16-like protein [Shewanella den... 491 e-136
ref|ZP_01485575.1| hypothetical protein VchoV5_02001802 [Vi... 491 e-136
emb|CAO77947.1| nardilysin, N-arginine dibasic convertase, ... 491 e-136
ref|ZP_01474320.1| hypothetical protein VEx2w_02003082 [Vib... 491 e-136
ref|YP_001761387.1| peptidase M16 domain protein [Shewanell... 491 e-136
ref|YP_001366970.1| peptidase M16 domain protein [Shewanell... 489 e-136
ref|YP_869105.1| peptidase M16 domain protein [Shewanella s... 488 e-136
ref|ZP_01844037.1| peptidase M16 domain protein [Shewanella... 488 e-135
ref|YP_001051112.1| peptidase M16 domain protein [Shewanell... 488 e-135
ref|YP_001555276.1| peptidase M16 domain protein [Shewanell... 488 e-135
ref|XP_001760921.1| predicted protein [Physcomitrella paten... 487 e-135
ref|YP_001094545.1| peptidase M16 domain protein [Shewanell... 485 e-135
ref|XP_001623609.1| predicted protein [Nematostella vectens... 485 e-135
ref|YP_001502447.1| peptidase M16 domain protein [Shewanell... 484 e-134
ref|ZP_01258854.1| peptidase, insulinase family protein [Vi... 484 e-134
ref|NP_935232.1| peptidase, insulinase family [Vibrio vulni... 484 e-134
ref|ZP_01987074.1| insulin-degrading enzyme [Vibrio harveyi... 483 e-134
ref|ZP_01307403.1| Secreted/periplasmic Zn-dependent peptid... 483 e-134
ref|YP_001473373.1| peptidase M16 domain protein [Shewanell... 483 e-134
ref|NP_760850.1| Peptidase [Vibrio vulnificus CMCP6] >gi|27... 482 e-134
ref|YP_751350.1| peptidase M16 domain protein [Shewanella f... 480 e-133
ref|YP_928038.1| peptidase, M16 family [Shewanella amazonen... 479 e-133
ref|ZP_02195786.1| peptidase, insulinase family protein [Vi... 479 e-133
ref|ZP_01866422.1| peptidase, insulinase family protein [Vi... 478 e-132
ref|ZP_01813161.1| peptidase, insulinase family protein [Vi... 477 e-132
ref|ZP_01064420.1| peptidase, insulinase family protein [Vi... 476 e-132
ref|ZP_01896589.1| putative peptidase, insulinase family [M... 470 e-130
ref|ZP_00990723.1| peptidase, insulinase family [Vibrio spl... 469 e-130
ref|XP_966800.1| PREDICTED: similar to Nardilysin precursor... 460 e-127
ref|XP_001012179.1| Insulysin, Insulin-degrading enzyme [Te... 459 e-127
ref|XP_504079.1| hypothetical protein [Yarrowia lipolytica]... 459 e-127
ref|YP_001446294.1| hypothetical protein VIBHAR_03118 [Vibr... 458 e-127
ref|ZP_01114527.1| Secreted/periplasmic Zn-dependent peptid... 453 e-125
ref|XP_001660612.1| metalloendopeptidase [Aedes aegypti] >g... 451 e-124
gb|AAL15441.1| nardilysin [Homo sapiens] 446 e-123
ref|XP_001844193.1| nardilysin [Culex pipiens quinquefascia... 442 e-122
ref|XP_001599332.1| PREDICTED: similar to metalloendopeptid... 439 e-121
emb|CAL51499.1| peptidase M16 family protein / insulinase f... 432 e-119
ref|XP_001417159.1| predicted protein [Ostreococcus lucimar... 431 e-118
ref|ZP_01613408.1| protease III [Alteromonadales bacterium ... 428 e-117
ref|ZP_01680540.1| peptidase, M16 (pitrilysin) family [Vibr... 427 e-117
ref|XP_624437.2| PREDICTED: similar to Nardilysin precursor... 422 e-116
ref|XP_320119.6| AGAP010315-PA [Anopheles gambiae str. PEST... 418 e-114
ref|YP_339493.1| peptidase [Pseudoalteromonas haloplanktis ... 415 e-113
ref|XP_001024563.1| insulysin, putative [Tetrahymena thermo... 414 e-113
ref|XP_001454805.1| hypothetical protein GSPATT00021051001 ... 411 e-112
ref|ZP_01043970.1| Zn-dependent peptidase, insulinase famil... 411 e-112
gb|ACO61422.1| predicted protein [Micromonas sp. RCC299] 405 e-111
ref|ZP_01132694.1| putative peptidase [Pseudoalteromonas tu... 404 e-110
ref|XP_001229657.1| hypothetical protein CHGG_03141 [Chaeto... 403 e-110
ref|YP_575066.1| peptidase M16-like protein [Chromohalobact... 403 e-110
ref|XP_001355509.1| GA15192-PA [Drosophila pseudoobscura] >... 401 e-109
gb|EEH57726.1| predicted protein [Micromonas pusilla CCMP1545] 400 e-109
ref|YP_269852.1| zinc metallopeptidase, M16 family [Colwell... 397 e-108
ref|YP_661242.1| peptidase M16-like [Pseudoalteromonas atla... 396 e-108
dbj|BAE88995.1| unnamed protein product [Macaca fascicularis] 388 e-105
ref|YP_155380.1| Zn-dependent peptidase, insulinase family ... 381 e-103
ref|NP_649271.1| CG10588 CG10588-PA [Drosophila melanogaste... 380 e-103
ref|YP_944762.1| peptidase M16 domain protein [Psychromonas... 378 e-102
ref|NP_572757.2| CG2025 CG2025-PA [Drosophila melanogaster]... 375 e-101
ref|YP_049101.1| protease III precursor [Erwinia carotovora... 374 e-101
ref|ZP_01075184.1| peptidase, insulinase family protein [Ma... 374 e-101
gb|AAV36919.1| RE02581p [Drosophila melanogaster] 374 e-101
ref|ZP_03833747.1| protease III precursor [Pectobacterium c... 373 e-101
ref|YP_001007484.1| protease III precursor [Yersinia entero... 370 e-100
ref|ZP_01216040.1| Secreted Zn-dependent peptidase, insulin... 367 3e-99
ref|YP_156717.1| Secreted Zn-dependent peptidase, insulinas... 366 4e-99
ref|ZP_03829109.1| protease III precursor [Pectobacterium c... 366 5e-99
ref|NP_001044431.1| Os01g0779100 [Oryza sativa (japonica cu... 363 5e-98
ref|XP_637100.1| hypothetical protein DDBDRAFT_0187681 [Dic... 360 3e-97
ref|YP_001341710.1| peptidase M16 domain protein [Marinomon... 360 3e-97
ref|ZP_01042947.1| Secreted Zn-dependent peptidase, insulin... 358 1e-96
gb|AAI34860.1| Si:dkey-171o17.4 protein [Danio rerio] 357 3e-96
ref|ZP_00827012.1| COG1025: Secreted/periplasmic Zn-depende... 357 3e-96
ref|XP_001509651.1| PREDICTED: similar to nardilysin (N-arg... 356 4e-96
ref|ZP_03838288.1| hypothetical protein CATC2_19978 [Citrob... 356 5e-96
ref|ZP_00822919.1| COG1025: Secreted/periplasmic Zn-depende... 356 5e-96
ref|NP_755290.1| Protease III precursor [Escherichia coli C... 355 1e-95
ref|ZP_00834380.1| COG1025: Secreted/periplasmic Zn-depende... 354 2e-95
ref|YP_001719796.1| peptidase M16 domain protein [Yersinia ... 354 2e-95
ref|ZP_00830096.1| COG1025: Secreted/periplasmic Zn-depende... 354 2e-95
gb|EAZ13746.1| hypothetical protein OsJ_003571 [Oryza sativ... 353 4e-95
ref|ZP_02959293.1| hypothetical protein PROSTU_01129 [Provi... 353 4e-95
ref|NP_404633.1| protease III precursor [Yersinia pestis CO... 352 7e-95
ref|YP_542202.1| protease III precursor [Escherichia coli U... 352 7e-95
ref|YP_311808.1| protease III [Shigella sonnei Ss046] >gi|7... 352 8e-95
gb|EEH94306.1| protease III [Citrobacter sp. 30_2] 352 8e-95
ref|NP_872791.1| protease III [Haemophilus ducreyi 35000HP]... 352 1e-94
ref|ZP_01111496.1| peptidase, M16 family protein [Alteromon... 351 2e-94
ref|YP_001744989.1| protease III [Escherichia coli SMS-3-5]... 351 2e-94
ref|ZP_00920643.1| COG1025: Secreted/periplasmic Zn-depende... 351 2e-94
ref|NP_311705.1| protease III [Escherichia coli O157:H7 str... 351 2e-94
ref|ZP_02900475.1| protease III [Escherichia albertii TW076... 351 2e-94
ref|XP_626324.1| peptidase'insulinase-like peptidase' [Cryp... 350 3e-94
ref|ZP_00714851.1| COG1025: Secreted/periplasmic Zn-depende... 350 3e-94
ref|NP_708612.1| protease III [Shigella flexneri 2a str. 30... 350 3e-94
>ref|NP_004960.2| insulysin [Homo sapiens]
emb|CAI13670.1| insulin-degrading enzyme [Homo sapiens]
gb|AAH96337.1| Insulin-degrading enzyme [Homo sapiens]
gb|AAH96339.1| Insulin-degrading enzyme [Homo sapiens]
gb|AAH96336.1| Insulin-degrading enzyme [Homo sapiens]
gb|EAW50090.1| insulin-degrading enzyme, isoform CRA_a [Homo sapiens]
gb|EAW50091.1| insulin-degrading enzyme, isoform CRA_a [Homo sapiens]
Length = 1019
Score = 2081 bits (5392), Expect = 0.0, Method: Composition-based stats.
Identities = 1019/1019 (100%), Positives = 1019/1019 (100%)
Query: 1 MRYRLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED 60
MRYRLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED
Sbjct: 1 MRYRLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED 60
Query: 61 KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK 120
KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK
Sbjct: 61 KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK 120
Query: 121 YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD 180
YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD
Sbjct: 121 YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD 180
Query: 181 REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE 240
REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE
Sbjct: 181 REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE 240
Query: 241 LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ 300
LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ
Sbjct: 241 LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ 300
Query: 301 LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV 360
LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV
Sbjct: 301 LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV 360
Query: 361 GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 420
GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV
Sbjct: 361 GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 420
Query: 421 AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI 480
AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI
Sbjct: 421 AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI 480
Query: 481 VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL 540
VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL
Sbjct: 481 VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL 540
Query: 541 EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL 600
EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL
Sbjct: 541 EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL 600
Query: 601 KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE 660
KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE
Sbjct: 601 KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE 660
Query: 661 IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 720
IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL
Sbjct: 661 IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 720
Query: 721 SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 780
SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ
Sbjct: 721 SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 780
Query: 781 QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 840
QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA
Sbjct: 781 QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 840
Query: 841 NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL 900
NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL
Sbjct: 841 NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL 900
Query: 901 SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA 960
SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA
Sbjct: 901 SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA 960
Query: 961 REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL 1019
REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL
Sbjct: 961 REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL 1019
>ref|XP_507922.2| PREDICTED: insulysin isoform 4 [Pan troglodytes]
Length = 1019
Score = 2079 bits (5387), Expect = 0.0, Method: Composition-based stats.
Identities = 1018/1019 (99%), Positives = 1018/1019 (99%)
Query: 1 MRYRLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED 60
MRYRLAWLLHPAL STFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED
Sbjct: 1 MRYRLAWLLHPALSSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED 60
Query: 61 KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK 120
KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK
Sbjct: 61 KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK 120
Query: 121 YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD 180
YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD
Sbjct: 121 YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD 180
Query: 181 REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE 240
REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE
Sbjct: 181 REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE 240
Query: 241 LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ 300
LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ
Sbjct: 241 LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ 300
Query: 301 LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV 360
LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV
Sbjct: 301 LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV 360
Query: 361 GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 420
GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV
Sbjct: 361 GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 420
Query: 421 AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI 480
AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI
Sbjct: 421 AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI 480
Query: 481 VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL 540
VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL
Sbjct: 481 VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL 540
Query: 541 EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL 600
EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL
Sbjct: 541 EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL 600
Query: 601 KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE 660
KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE
Sbjct: 601 KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE 660
Query: 661 IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 720
IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL
Sbjct: 661 IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 720
Query: 721 SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 780
SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ
Sbjct: 721 SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 780
Query: 781 QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 840
QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA
Sbjct: 781 QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 840
Query: 841 NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL 900
NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL
Sbjct: 841 NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL 900
Query: 901 SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA 960
SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA
Sbjct: 901 SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA 960
Query: 961 REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL 1019
REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL
Sbjct: 961 REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL 1019
>ref|XP_001501085.1| PREDICTED: similar to insulin-degrading enzyme [Equus caballus]
Length = 1212
Score = 2075 bits (5376), Expect = 0.0, Method: Composition-based stats.
Identities = 1005/1019 (98%), Positives = 1012/1019 (99%)
Query: 1 MRYRLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED 60
MRYRLAWLLHPALPSTFRS LGARLPPPERL GFQKKTYSKMNNPAIKR+GNHI KSPED
Sbjct: 194 MRYRLAWLLHPALPSTFRSALGARLPPPERLSGFQKKTYSKMNNPAIKRLGNHIIKSPED 253
Query: 61 KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK 120
KREYRGL+LANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK
Sbjct: 254 KREYRGLQLANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK 313
Query: 121 YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD 180
YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD
Sbjct: 314 YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD 373
Query: 181 REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE 240
REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE
Sbjct: 374 REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE 433
Query: 241 LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ 300
LLKFHS YYSSNLMA+CVLGRESLDDLT+LVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ
Sbjct: 434 LLKFHSTYYSSNLMAICVLGRESLDDLTDLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ 493
Query: 301 LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV 360
LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV
Sbjct: 494 LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV 553
Query: 361 GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 420
GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV
Sbjct: 554 GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 613
Query: 421 AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI 480
AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVA+
Sbjct: 614 AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAV 673
Query: 481 VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL 540
VSKSFEGKTD TEEWYGTQY+QEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEIL L
Sbjct: 674 VSKSFEGKTDCTEEWYGTQYRQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILSL 733
Query: 541 EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL 600
EKEATPYP+LIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL
Sbjct: 734 EKEATPYPSLIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL 793
Query: 601 KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE 660
KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE
Sbjct: 794 KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE 853
Query: 661 IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 720
IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL
Sbjct: 854 IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 913
Query: 721 SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 780
SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ
Sbjct: 914 SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 973
Query: 781 QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 840
QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA
Sbjct: 974 QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 1033
Query: 841 NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL 900
NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL
Sbjct: 1034 NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL 1093
Query: 901 SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA 960
SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA
Sbjct: 1094 SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA 1153
Query: 961 REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL 1019
REMDSCPVVGEFPCQNDINLSQAP LPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL
Sbjct: 1154 REMDSCPVVGEFPCQNDINLSQAPGLPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL 1212
>ref|XP_001090249.1| PREDICTED: insulysin isoform 3 [Macaca mulatta]
Length = 1019
Score = 2071 bits (5366), Expect = 0.0, Method: Composition-based stats.
Identities = 1013/1019 (99%), Positives = 1016/1019 (99%)
Query: 1 MRYRLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED 60
MRYRLAWL HPALPSTFRSV GARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED
Sbjct: 1 MRYRLAWLRHPALPSTFRSVFGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED 60
Query: 61 KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK 120
KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK
Sbjct: 61 KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK 120
Query: 121 YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD 180
YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD
Sbjct: 121 YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD 180
Query: 181 REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE 240
REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE
Sbjct: 181 REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE 240
Query: 241 LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ 300
LLKFHS YYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENK+VPLPEFPEHPFQEEHLKQ
Sbjct: 241 LLKFHSTYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKSVPLPEFPEHPFQEEHLKQ 300
Query: 301 LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV 360
LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV
Sbjct: 301 LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV 360
Query: 361 GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 420
GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV
Sbjct: 361 GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 420
Query: 421 AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI 480
AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVA+
Sbjct: 421 AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAV 480
Query: 481 VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL 540
VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL
Sbjct: 481 VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL 540
Query: 541 EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL 600
EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL
Sbjct: 541 EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL 600
Query: 601 KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE 660
KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE
Sbjct: 601 KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE 660
Query: 661 IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 720
IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL
Sbjct: 661 IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 720
Query: 721 SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 780
SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ
Sbjct: 721 SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 780
Query: 781 QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 840
QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA
Sbjct: 781 QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 840
Query: 841 NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL 900
NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL
Sbjct: 841 NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL 900
Query: 901 SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA 960
SAECAKYWGEIISQQY+FDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA
Sbjct: 901 SAECAKYWGEIISQQYHFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA 960
Query: 961 REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL 1019
REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL
Sbjct: 961 REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL 1019
>ref|NP_001069317.1| insulin-degrading enzyme [Bos taurus]
sp|Q24K02|IDE_BOVIN Insulin-degrading enzyme (Insulysin) (Insulinase) (Insulin protease)
gb|AAI14106.1| Similar to Insulin-degrading enzyme (Insulysin) (Insulinase) (Insulin
protease) [Bos taurus]
Length = 1019
Score = 2058 bits (5332), Expect = 0.0, Method: Composition-based stats.
Identities = 1007/1019 (98%), Positives = 1011/1019 (99%)
Query: 1 MRYRLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED 60
MRYRLAWLLH ALPSTFRSVLGARLPP ERLCGFQKKTYSKMNNPAIKRIG+HI KS ED
Sbjct: 1 MRYRLAWLLHSALPSTFRSVLGARLPPSERLCGFQKKTYSKMNNPAIKRIGHHIIKSHED 60
Query: 61 KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK 120
KREYRGLELANGIKVLL+SDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK
Sbjct: 61 KREYRGLELANGIKVLLVSDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK 120
Query: 121 YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD 180
YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD
Sbjct: 121 YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD 180
Query: 181 REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE 240
REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE
Sbjct: 181 REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE 240
Query: 241 LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ 300
LLKFHS YYSSNLMA+CVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ
Sbjct: 241 LLKFHSTYYSSNLMAICVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ 300
Query: 301 LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV 360
LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV
Sbjct: 301 LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV 360
Query: 361 GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 420
GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV
Sbjct: 361 GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 420
Query: 421 AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI 480
AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI
Sbjct: 421 AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI 480
Query: 481 VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL 540
VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLP KNEFIPTNFEIL L
Sbjct: 481 VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPMKNEFIPTNFEILSL 540
Query: 541 EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL 600
EKEATPYP+LIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL
Sbjct: 541 EKEATPYPSLIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL 600
Query: 601 KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE 660
KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE
Sbjct: 601 KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE 660
Query: 661 IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 720
IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL
Sbjct: 661 IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 720
Query: 721 SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 780
SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ
Sbjct: 721 SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 780
Query: 781 QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 840
QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA
Sbjct: 781 QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 840
Query: 841 NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL 900
NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL
Sbjct: 841 NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL 900
Query: 901 SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA 960
SAECAKYWGEIISQQYNFDRDN EVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA
Sbjct: 901 SAECAKYWGEIISQQYNFDRDNIEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA 960
Query: 961 REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL 1019
REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL
Sbjct: 961 REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL 1019
>sp|P14735|IDE_HUMAN Insulin-degrading enzyme (Insulysin) (Insulinase) (Insulin protease)
gb|AAA52712.1| insulin-degrading enzyme
Length = 1019
Score = 2052 bits (5316), Expect = 0.0, Method: Composition-based stats.
Identities = 1013/1019 (99%), Positives = 1014/1019 (99%)
Query: 1 MRYRLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED 60
MRYRLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED
Sbjct: 1 MRYRLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED 60
Query: 61 KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK 120
KREYRGLELANGIKVLL+SDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK
Sbjct: 61 KREYRGLELANGIKVLLMSDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK 120
Query: 121 YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD 180
YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD
Sbjct: 121 YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD 180
Query: 181 REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE 240
REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE
Sbjct: 181 REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE 240
Query: 241 LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ 300
LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ
Sbjct: 241 LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ 300
Query: 301 LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV 360
LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV
Sbjct: 301 LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV 360
Query: 361 GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 420
GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV
Sbjct: 361 GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 420
Query: 421 AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI 480
AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI
Sbjct: 421 AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI 480
Query: 481 VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL 540
VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL
Sbjct: 481 VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL 540
Query: 541 EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL 600
EKEATPYPALIKDT MSKLWFKQDDK PKACLNFEFFSPFAYVDPLHCNMAYLYLELL
Sbjct: 541 EKEATPYPALIKDTVMSKLWFKQDDKKKKPKACLNFEFFSPFAYVDPLHCNMAYLYLELL 600
Query: 601 KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE 660
KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE
Sbjct: 601 KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE 660
Query: 661 IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 720
IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL
Sbjct: 661 IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 720
Query: 721 SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 780
SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ
Sbjct: 721 SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 780
Query: 781 QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 840
QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA
Sbjct: 781 QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 840
Query: 841 NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL 900
NGIQ LRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL
Sbjct: 841 NGIQSLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL 900
Query: 901 SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA 960
SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA
Sbjct: 901 SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA 960
Query: 961 REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL 1019
REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL
Sbjct: 961 REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL 1019
>ref|XP_001146582.1| PREDICTED: insulysin isoform 3 [Pan troglodytes]
Length = 1019
Score = 2038 bits (5279), Expect = 0.0, Method: Composition-based stats.
Identities = 995/1019 (97%), Positives = 1003/1019 (98%)
Query: 1 MRYRLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED 60
MRYRLAWLLHPAL STFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED
Sbjct: 1 MRYRLAWLLHPALSSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED 60
Query: 61 KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK 120
KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK
Sbjct: 61 KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK 120
Query: 121 YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD 180
YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD
Sbjct: 121 YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD 180
Query: 181 REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE 240
REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE
Sbjct: 181 REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE 240
Query: 241 LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ 300
LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ
Sbjct: 241 LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ 300
Query: 301 LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV 360
LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV
Sbjct: 301 LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV 360
Query: 361 GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 420
GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV
Sbjct: 361 GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 420
Query: 421 AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI 480
AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI
Sbjct: 421 AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI 480
Query: 481 VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL 540
VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL
Sbjct: 481 VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL 540
Query: 541 EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL 600
EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFS + Y DPLHCNM YL++ LL
Sbjct: 541 EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSRYIYADPLHCNMTYLFIRLL 600
Query: 601 KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE 660
KD L EY YAA L+GLSY + + + + LSVKGYNDKQPILLKKIIEKMATFEIDEKRFE
Sbjct: 601 KDDLKEYTYAARLSGLSYGIASGMNAILLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE 660
Query: 661 IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 720
IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL
Sbjct: 661 IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 720
Query: 721 SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 780
SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ
Sbjct: 721 SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 780
Query: 781 QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 840
QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA
Sbjct: 781 QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 840
Query: 841 NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL 900
NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL
Sbjct: 841 NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL 900
Query: 901 SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA 960
SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA
Sbjct: 901 SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA 960
Query: 961 REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL 1019
REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL
Sbjct: 961 REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL 1019
>ref|NP_037291.1| insulin degrading enzyme [Rattus norvegicus]
sp|P35559|IDE_RAT Insulin-degrading enzyme (Insulysin) (Insulinase) (Insulin protease)
emb|CAA47689.1| insulin-degrading enzyme [Rattus norvegicus]
gb|EDM13196.1| insulin degrading enzyme [Rattus norvegicus]
Length = 1019
Score = 1998 bits (5175), Expect = 0.0, Method: Composition-based stats.
Identities = 973/1019 (95%), Positives = 995/1019 (97%)
Query: 1 MRYRLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED 60
MR L WLLHPALPST S+LGAR PP +RLCGF K+ YS MNNPAI+RI +HI KSPED
Sbjct: 1 MRNGLVWLLHPALPSTLHSILGARPPPVKRLCGFPKQIYSTMNNPAIQRIEDHIVKSPED 60
Query: 61 KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK 120
KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNI GLSHFCEHMLFLGTKK
Sbjct: 61 KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIPGLSHFCEHMLFLGTKK 120
Query: 121 YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD 180
YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFD SCKD
Sbjct: 121 YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDASCKD 180
Query: 181 REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE 240
REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVR+E
Sbjct: 181 REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVREE 240
Query: 241 LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ 300
LLKFHS YYSSNLMA+CVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ
Sbjct: 241 LLKFHSTYYSSNLMAICVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ 300
Query: 301 LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV 360
LYKIVPIKDIRNLYVTFPIPDLQ+YYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV
Sbjct: 301 LYKIVPIKDIRNLYVTFPIPDLQQYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV 360
Query: 361 GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 420
GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV
Sbjct: 361 GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 420
Query: 421 AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI 480
AFRFKDKERPRGYTSKIAG LHYYPL VLTAEYLLEEFRPDLI+MVLDKLRPENVRVAI
Sbjct: 421 AFRFKDKERPRGYTSKIAGKLHYYPLNGVLTAEYLLEEFRPDLIDMVLDKLRPENVRVAI 480
Query: 481 VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL 540
VSKSFEGKTDRTE+WYGTQYKQEAIP++VI+KWQNADLNGKFKLPTKNEFIPTNFEIL L
Sbjct: 481 VSKSFEGKTDRTEQWYGTQYKQEAIPEDVIQKWQNADLNGKFKLPTKNEFIPTNFEILAL 540
Query: 541 EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL 600
EK+ATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL
Sbjct: 541 EKDATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL 600
Query: 601 KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE 660
KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKI EKMATFEID+KRFE
Sbjct: 601 KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKITEKMATFEIDKKRFE 660
Query: 661 IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 720
IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL
Sbjct: 661 IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 720
Query: 721 SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 780
SRLHIEALLHGNITKQAALG+MQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ
Sbjct: 721 SRLHIEALLHGNITKQAALGVMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 780
Query: 781 QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 840
+RNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA
Sbjct: 781 RRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 840
Query: 841 NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL 900
NGIQGLRFIIQSEKPPHYLESRVEAFLITMEK+IEDMTEEAFQKHIQALAIRRLDKPKKL
Sbjct: 841 NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKAIEDMTEEAFQKHIQALAIRRLDKPKKL 900
Query: 901 SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA 960
SAECAKYWGEIISQQYN+DRDN EVAYLKTL+K+DIIKFYKEMLAVDAPRRHKVSVHVLA
Sbjct: 901 SAECAKYWGEIISQQYNYDRDNIEVAYLKTLSKDDIIKFYKEMLAVDAPRRHKVSVHVLA 960
Query: 961 REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL 1019
REMDSCPVVGEFP QNDINLS+AP LPQPEVI NMTEFKRGLPLFPLVKPHINFMAAKL
Sbjct: 961 REMDSCPVVGEFPSQNDINLSEAPPLPQPEVIHNMTEFKRGLPLFPLVKPHINFMAAKL 1019
>ref|NP_112419.2| insulin degrading enzyme [Mus musculus]
gb|AAH41675.1| Insulin degrading enzyme [Mus musculus]
Length = 1019
Score = 1996 bits (5171), Expect = 0.0, Method: Composition-based stats.
Identities = 970/1019 (95%), Positives = 995/1019 (97%)
Query: 1 MRYRLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED 60
MR L WLLHPALP T RS+LGAR PP +RLCGF K+TYS M+NPAI+RI + I KSPED
Sbjct: 1 MRNGLVWLLHPALPGTLRSILGARPPPAKRLCGFPKQTYSTMSNPAIQRIEDQIVKSPED 60
Query: 61 KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK 120
KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNI GLSHFCEHMLFLGTKK
Sbjct: 61 KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIPGLSHFCEHMLFLGTKK 120
Query: 121 YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD 180
YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFD SCKD
Sbjct: 121 YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDASCKD 180
Query: 181 REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE 240
REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVR+E
Sbjct: 181 REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVREE 240
Query: 241 LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ 300
LLKFHS YYSSNLMA+CVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHL+Q
Sbjct: 241 LLKFHSTYYSSNLMAICVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLRQ 300
Query: 301 LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV 360
LYKIVPIKDIRNLYVTFPIPDLQ+YYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV
Sbjct: 301 LYKIVPIKDIRNLYVTFPIPDLQQYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV 360
Query: 361 GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 420
GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV
Sbjct: 361 GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 420
Query: 421 AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI 480
AFRFKDKERPRGYTSKIAG LHYYPL VLTAEYLLEEFRPDLI+MVLDKLRPENVRVAI
Sbjct: 421 AFRFKDKERPRGYTSKIAGKLHYYPLNGVLTAEYLLEEFRPDLIDMVLDKLRPENVRVAI 480
Query: 481 VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL 540
VSKSFEGKTDRTE+WYGTQYKQEAIP+++I+KWQNADLNGKFKLPTKNEFIPTNFEIL L
Sbjct: 481 VSKSFEGKTDRTEQWYGTQYKQEAIPEDIIQKWQNADLNGKFKLPTKNEFIPTNFEILSL 540
Query: 541 EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL 600
EK+ATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL
Sbjct: 541 EKDATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL 600
Query: 601 KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE 660
KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKI EKMATFEID+KRFE
Sbjct: 601 KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKITEKMATFEIDKKRFE 660
Query: 661 IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 720
IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL
Sbjct: 661 IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 720
Query: 721 SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 780
SRLHIEALLHGNITKQAALG+MQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ
Sbjct: 721 SRLHIEALLHGNITKQAALGVMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 780
Query: 781 QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 840
QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA
Sbjct: 781 QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 840
Query: 841 NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL 900
NGIQGLRFIIQSEKPPHYLESRVEAFLITMEK+IEDMTEEAFQKHIQALAIRRLDKPKKL
Sbjct: 841 NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKAIEDMTEEAFQKHIQALAIRRLDKPKKL 900
Query: 901 SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA 960
SAECAKYWGEIISQQYN+DRDN EVAYLKTLTK+DII+FY+EMLAVDAPRRHKVSVHVLA
Sbjct: 901 SAECAKYWGEIISQQYNYDRDNIEVAYLKTLTKDDIIRFYQEMLAVDAPRRHKVSVHVLA 960
Query: 961 REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL 1019
REMDSCPVVGEFP QNDINLS+AP LPQPEVI NMTEFKRGLPLFPLVKPHINFMAAKL
Sbjct: 961 REMDSCPVVGEFPSQNDINLSEAPPLPQPEVIHNMTEFKRGLPLFPLVKPHINFMAAKL 1019
>pdb|2G47|A Chain A, Crystal Structure Of Human Insulin-Degrading Enzyme In
Complex With Amyloid-Beta (1-40)
pdb|2G47|B Chain B, Crystal Structure Of Human Insulin-Degrading Enzyme In
Complex With Amyloid-Beta (1-40)
pdb|2G48|A Chain A, Crystal Structure Of Human Insulin-Degrading Enzyme In
Complex With Amylin
pdb|2G48|B Chain B, Crystal Structure Of Human Insulin-Degrading Enzyme In
Complex With Amylin
pdb|2G49|A Chain A, Crystal Structure Of Human Insulin-Degrading Enzyme In
Complex With Glucagon
pdb|2G49|B Chain B, Crystal Structure Of Human Insulin-Degrading Enzyme In
Complex With Glucagon
pdb|2G54|A Chain A, Crystal Structure Of Zn-Bound Human Insulin-Degrading Enzyme
In Complex With Insulin B Chain
pdb|2G54|B Chain B, Crystal Structure Of Zn-Bound Human Insulin-Degrading Enzyme
In Complex With Insulin B Chain
pdb|2G56|A Chain A, Crystal Structure Of Human Insulin-Degrading Enzyme In
Complex With Insulin B Chain
pdb|2G56|B Chain B, Crystal Structure Of Human Insulin-Degrading Enzyme In
Complex With Insulin B Chain
pdb|2JBU|A Chain A, Crystal Structure Of Human Insulin Degrading Enzyme
Complexed With Co-Purified Peptides.
pdb|2JBU|B Chain B, Crystal Structure Of Human Insulin Degrading Enzyme
Complexed With Co-Purified Peptides.
Length = 990
Score = 1994 bits (5166), Expect = 0.0, Method: Composition-based stats.
Identities = 977/978 (99%), Positives = 978/978 (100%)
Query: 42 MNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPP 101
MNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPP
Sbjct: 13 MNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPP 72
Query: 102 NIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGA 161
NIAGLSHFC+HMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGA
Sbjct: 73 NIAGLSHFCQHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGA 132
Query: 162 LDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTG 221
LDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTG
Sbjct: 133 LDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTG 192
Query: 222 NKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENK 281
NKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENK
Sbjct: 193 NKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENK 252
Query: 282 NVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHE 341
NVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHE
Sbjct: 253 NVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHE 312
Query: 342 GPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKL 401
GPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKL
Sbjct: 313 GPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKL 372
Query: 402 RAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRP 461
RAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRP
Sbjct: 373 RAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRP 432
Query: 462 DLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGK 521
DLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGK
Sbjct: 433 DLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGK 492
Query: 522 FKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSP 581
FKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSP
Sbjct: 493 FKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSP 552
Query: 582 FAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPIL 641
FAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPIL
Sbjct: 553 FAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPIL 612
Query: 642 LKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELK 701
LKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELK
Sbjct: 613 LKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELK 672
Query: 702 EALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPS 761
EALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPS
Sbjct: 673 EALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPS 732
Query: 762 QLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFN 821
QLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFN
Sbjct: 733 QLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFN 792
Query: 822 TLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEA 881
TLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEA
Sbjct: 793 TLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEA 852
Query: 882 FQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYK 941
FQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYK
Sbjct: 853 FQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYK 912
Query: 942 EMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRG 1001
EMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRG
Sbjct: 913 EMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRG 972
Query: 1002 LPLFPLVKPHINFMAAKL 1019
LPLFPLVKPHINFMAAKL
Sbjct: 973 LPLFPLVKPHINFMAAKL 990
>ref|XP_001146520.1| PREDICTED: insulysin isoform 2 [Pan troglodytes]
gb|EAW50093.1| insulin-degrading enzyme, isoform CRA_c [Homo sapiens]
Length = 978
Score = 1994 bits (5166), Expect = 0.0, Method: Composition-based stats.
Identities = 978/978 (100%), Positives = 978/978 (100%)
Query: 42 MNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPP 101
MNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPP
Sbjct: 1 MNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPP 60
Query: 102 NIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGA 161
NIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGA
Sbjct: 61 NIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGA 120
Query: 162 LDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTG 221
LDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTG
Sbjct: 121 LDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTG 180
Query: 222 NKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENK 281
NKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENK
Sbjct: 181 NKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENK 240
Query: 282 NVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHE 341
NVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHE
Sbjct: 241 NVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHE 300
Query: 342 GPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKL 401
GPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKL
Sbjct: 301 GPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKL 360
Query: 402 RAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRP 461
RAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRP
Sbjct: 361 RAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRP 420
Query: 462 DLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGK 521
DLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGK
Sbjct: 421 DLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGK 480
Query: 522 FKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSP 581
FKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSP
Sbjct: 481 FKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSP 540
Query: 582 FAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPIL 641
FAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPIL
Sbjct: 541 FAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPIL 600
Query: 642 LKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELK 701
LKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELK
Sbjct: 601 LKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELK 660
Query: 702 EALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPS 761
EALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPS
Sbjct: 661 EALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPS 720
Query: 762 QLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFN 821
QLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFN
Sbjct: 721 QLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFN 780
Query: 822 TLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEA 881
TLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEA
Sbjct: 781 TLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEA 840
Query: 882 FQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYK 941
FQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYK
Sbjct: 841 FQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYK 900
Query: 942 EMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRG 1001
EMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRG
Sbjct: 901 EMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRG 960
Query: 1002 LPLFPLVKPHINFMAAKL 1019
LPLFPLVKPHINFMAAKL
Sbjct: 961 LPLFPLVKPHINFMAAKL 978
>pdb|2JG4|A Chain A, Substrate-Free Ide Structure In Its Closed Conformation
pdb|2JG4|B Chain B, Substrate-Free Ide Structure In Its Closed Conformation
Length = 990
Score = 1994 bits (5166), Expect = 0.0, Method: Composition-based stats.
Identities = 977/978 (99%), Positives = 978/978 (100%)
Query: 42 MNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPP 101
MNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPP
Sbjct: 13 MNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPP 72
Query: 102 NIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGA 161
NIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGA
Sbjct: 73 NIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGA 132
Query: 162 LDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTG 221
LDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTG
Sbjct: 133 LDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTG 192
Query: 222 NKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENK 281
NKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENK
Sbjct: 193 NKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENK 252
Query: 282 NVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHE 341
NVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHE
Sbjct: 253 NVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHE 312
Query: 342 GPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKL 401
GPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKL
Sbjct: 313 GPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKL 372
Query: 402 RAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRP 461
RAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRP
Sbjct: 373 RAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRP 432
Query: 462 DLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGK 521
DLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGK
Sbjct: 433 DLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGK 492
Query: 522 FKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSP 581
FKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSP
Sbjct: 493 FKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSP 552
Query: 582 FAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPIL 641
FAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPIL
Sbjct: 553 FAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPIL 612
Query: 642 LKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELK 701
LKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELK
Sbjct: 613 LKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELK 672
Query: 702 EALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPS 761
EALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPS
Sbjct: 673 EALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPS 732
Query: 762 QLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFN 821
QLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFN
Sbjct: 733 QLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFN 792
Query: 822 TLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEA 881
TLRTKEQLG+IVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEA
Sbjct: 793 TLRTKEQLGFIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEA 852
Query: 882 FQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYK 941
FQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYK
Sbjct: 853 FQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYK 912
Query: 942 EMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRG 1001
EMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRG
Sbjct: 913 EMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRG 972
Query: 1002 LPLFPLVKPHINFMAAKL 1019
LPLFPLVKPHINFMAAKL
Sbjct: 973 LPLFPLVKPHINFMAAKL 990
>sp|Q9JHR7|IDE_MOUSE Insulin-degrading enzyme (Insulysin) (Insulinase) (Insulin protease)
emb|CAC01233.1| insulin degrading enzyme [Mus musculus]
Length = 1019
Score = 1988 bits (5151), Expect = 0.0, Method: Composition-based stats.
Identities = 968/1019 (94%), Positives = 993/1019 (97%)
Query: 1 MRYRLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED 60
MR L WLLHPALP T RS+LGAR PP +RLCGF K+TYS M+NPAI+RI + I KSPED
Sbjct: 1 MRNGLVWLLHPALPGTLRSILGARPPPAKRLCGFPKQTYSTMSNPAIQRIEDQIVKSPED 60
Query: 61 KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK 120
KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNI GLSHFCEHMLFLGTKK
Sbjct: 61 KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIPGLSHFCEHMLFLGTKK 120
Query: 121 YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD 180
YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPL D SCKD
Sbjct: 121 YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLLDASCKD 180
Query: 181 REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE 240
REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVR+E
Sbjct: 181 REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVREE 240
Query: 241 LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ 300
LLKFHS YYSSNLMA+CVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHL+Q
Sbjct: 241 LLKFHSTYYSSNLMAICVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLRQ 300
Query: 301 LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV 360
LYKIVPIKDIRNLYVTFPIPDLQ+YYKSNPG+YLGHLIGHEGPGSLLSELKSKGWVNTLV
Sbjct: 301 LYKIVPIKDIRNLYVTFPIPDLQQYYKSNPGYYLGHLIGHEGPGSLLSELKSKGWVNTLV 360
Query: 361 GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 420
GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV
Sbjct: 361 GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 420
Query: 421 AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI 480
AFRFKDKERPRGYTSKIAG LHYYPL VLTAEYLLEEFRPDLI+MVLDKLRPENVRVAI
Sbjct: 421 AFRFKDKERPRGYTSKIAGKLHYYPLNGVLTAEYLLEEFRPDLIDMVLDKLRPENVRVAI 480
Query: 481 VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL 540
VSKSFEGKTDRTE+WYGTQYKQEAIP++VI+KWQNADLNGKFKLPTKNEFIPTNFEIL L
Sbjct: 481 VSKSFEGKTDRTEQWYGTQYKQEAIPEDVIQKWQNADLNGKFKLPTKNEFIPTNFEILSL 540
Query: 541 EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL 600
EK+ATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL
Sbjct: 541 EKDATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL 600
Query: 601 KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE 660
KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVK YNDKQPILLKKI EKMATFEID+KRFE
Sbjct: 601 KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKRYNDKQPILLKKITEKMATFEIDKKRFE 660
Query: 661 IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 720
IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL
Sbjct: 661 IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 720
Query: 721 SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 780
SRLHIEALLHGNITKQAALG+MQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ
Sbjct: 721 SRLHIEALLHGNITKQAALGVMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 780
Query: 781 QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 840
QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA
Sbjct: 781 QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 840
Query: 841 NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL 900
NGIQGLRFIIQSEKPPHYLESRVEAFLITMEK+IEDMTEEAFQKHIQALAIRRLDKPKKL
Sbjct: 841 NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKAIEDMTEEAFQKHIQALAIRRLDKPKKL 900
Query: 901 SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA 960
SAECAKYWGEIISQQYN+DRDN EVAYLKTLTK+DII+FY+EMLAVDAPRRHKVSVHVLA
Sbjct: 901 SAECAKYWGEIISQQYNYDRDNIEVAYLKTLTKDDIIRFYQEMLAVDAPRRHKVSVHVLA 960
Query: 961 REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL 1019
REMDSCPVVGEFP QNDINLS+AP LPQPEVI NMTEFKRGLPLFPLVKPHINFMAAKL
Sbjct: 961 REMDSCPVVGEFPSQNDINLSEAPPLPQPEVIHNMTEFKRGLPLFPLVKPHINFMAAKL 1019
>ref|XP_001090137.1| PREDICTED: insulysin isoform 2 [Macaca mulatta]
Length = 978
Score = 1988 bits (5150), Expect = 0.0, Method: Composition-based stats.
Identities = 974/978 (99%), Positives = 977/978 (99%)
Query: 42 MNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPP 101
MNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPP
Sbjct: 1 MNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPP 60
Query: 102 NIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGA 161
NIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGA
Sbjct: 61 NIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGA 120
Query: 162 LDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTG 221
LDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTG
Sbjct: 121 LDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTG 180
Query: 222 NKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENK 281
NKYTLETRPNQEGIDVRQELLKFHS YYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENK
Sbjct: 181 NKYTLETRPNQEGIDVRQELLKFHSTYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENK 240
Query: 282 NVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHE 341
+VPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHE
Sbjct: 241 SVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHE 300
Query: 342 GPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKL 401
GPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKL
Sbjct: 301 GPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKL 360
Query: 402 RAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRP 461
RAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRP
Sbjct: 361 RAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRP 420
Query: 462 DLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGK 521
DLIEMVLDKLRPENVRVA+VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGK
Sbjct: 421 DLIEMVLDKLRPENVRVAVVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGK 480
Query: 522 FKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSP 581
FKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSP
Sbjct: 481 FKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSP 540
Query: 582 FAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPIL 641
FAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPIL
Sbjct: 541 FAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPIL 600
Query: 642 LKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELK 701
LKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELK
Sbjct: 601 LKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELK 660
Query: 702 EALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPS 761
EALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPS
Sbjct: 661 EALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPS 720
Query: 762 QLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFN 821
QLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFN
Sbjct: 721 QLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFN 780
Query: 822 TLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEA 881
TLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEA
Sbjct: 781 TLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEA 840
Query: 882 FQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYK 941
FQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQY+FDRDNTEVAYLKTLTKEDIIKFYK
Sbjct: 841 FQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYHFDRDNTEVAYLKTLTKEDIIKFYK 900
Query: 942 EMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRG 1001
EMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRG
Sbjct: 901 EMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRG 960
Query: 1002 LPLFPLVKPHINFMAAKL 1019
LPLFPLVKPHINFMAAKL
Sbjct: 961 LPLFPLVKPHINFMAAKL 978
>ref|XP_534963.2| PREDICTED: similar to Insulin-degrading enzyme (Insulysin)
(Insulinase) (Insulin protease) [Canis familiaris]
Length = 994
Score = 1987 bits (5148), Expect = 0.0, Method: Composition-based stats.
Identities = 980/1019 (96%), Positives = 986/1019 (96%), Gaps = 25/1019 (2%)
Query: 1 MRYRLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED 60
MRY LAWLLH A PSTFRSVLGARLP PERLCGFQ+K+YSKMNNPAIKR+GNHI KSPED
Sbjct: 1 MRYPLAWLLHSARPSTFRSVLGARLPLPERLCGFQEKSYSKMNNPAIKRLGNHIIKSPED 60
Query: 61 KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK 120
KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK
Sbjct: 61 KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK 120
Query: 121 YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD 180
YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD
Sbjct: 121 YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD 180
Query: 181 REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE 240
REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE
Sbjct: 181 REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE 240
Query: 241 LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ 300
LLKFHS YYSSNLMA+CVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ
Sbjct: 241 LLKFHSTYYSSNLMAICVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ 300
Query: 301 LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV 360
LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV
Sbjct: 301 LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV 360
Query: 361 GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 420
GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV
Sbjct: 361 GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 420
Query: 421 AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI 480
AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI
Sbjct: 421 AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI 480
Query: 481 VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL 540
VSKSFEGKTDRTEEWYGTQYKQEA+PDEVIK IL L
Sbjct: 481 VSKSFEGKTDRTEEWYGTQYKQEAVPDEVIK-------------------------ILSL 515
Query: 541 EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL 600
EKEA PYP+LIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL
Sbjct: 516 EKEAHPYPSLIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL 575
Query: 601 KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE 660
KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE
Sbjct: 576 KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE 635
Query: 661 IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 720
IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL
Sbjct: 636 IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 695
Query: 721 SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 780
SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ
Sbjct: 696 SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 755
Query: 781 QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 840
QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA
Sbjct: 756 QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 815
Query: 841 NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL 900
NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL
Sbjct: 816 NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL 875
Query: 901 SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA 960
SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA
Sbjct: 876 SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA 935
Query: 961 REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL 1019
REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL
Sbjct: 936 REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL 994
>ref|XP_001506502.1| PREDICTED: similar to insulin-degrading enzyme [Ornithorhynchus
anatinus]
Length = 1301
Score = 1954 bits (5061), Expect = 0.0, Method: Composition-based stats.
Identities = 938/986 (95%), Positives = 964/986 (97%)
Query: 34 FQKKTYSKMNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVH 93
FQ+ +Y KM++ A+KRI N+I KSPEDKREYRGLELANGIK +LISDPTTDKSSAALDVH
Sbjct: 316 FQRYSYGKMDHSAVKRIVNNIIKSPEDKREYRGLELANGIKAILISDPTTDKSSAALDVH 375
Query: 94 IGSLSDPPNIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDV 153
IGSLSDPPNIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDV
Sbjct: 376 IGSLSDPPNIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDV 435
Query: 154 SHEHLEGALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKH 213
SHEHLEGALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNP H
Sbjct: 436 SHEHLEGALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPNH 495
Query: 214 PFSKFGTGNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVK 273
PFSKFGTGNKYTLETRP +EGIDVRQELLKFHS YYSSNLMA+CVLGRESLD+LT+LVVK
Sbjct: 496 PFSKFGTGNKYTLETRPTKEGIDVRQELLKFHSTYYSSNLMAICVLGRESLDELTSLVVK 555
Query: 274 LFSEVENKNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHY 333
LFSEVENKNVPLPEFPEHPFQE HL+Q+YK+VPIKDIRNLYVTFPIPDLQKYYKSNPGHY
Sbjct: 556 LFSEVENKNVPLPEFPEHPFQEHHLRQIYKVVPIKDIRNLYVTFPIPDLQKYYKSNPGHY 615
Query: 334 LGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILH 393
LGHLIGHEGPGSLLSELK+KGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILH
Sbjct: 616 LGHLIGHEGPGSLLSELKAKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILH 675
Query: 394 MFQYIQKLRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAE 453
MFQYIQKLR EGPQEWVFQECKDLNAVAFRFKDKERPRGYTSK+ G+LHYYPLEEVL AE
Sbjct: 676 MFQYIQKLRTEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKLGGMLHYYPLEEVLAAE 735
Query: 454 YLLEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKW 513
YLLEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTD+TEEWYGTQYKQEAI DEVIKKW
Sbjct: 736 YLLEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDQTEEWYGTQYKQEAISDEVIKKW 795
Query: 514 QNADLNGKFKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKAC 573
QNADLNGKFKLP KNEFIP+NFEIL LEKEA YPALIKDTAMSKLWFKQDDKFFLPKAC
Sbjct: 796 QNADLNGKFKLPMKNEFIPSNFEILQLEKEAPSYPALIKDTAMSKLWFKQDDKFFLPKAC 855
Query: 574 LNFEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKG 633
LNFEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKG
Sbjct: 856 LNFEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKG 915
Query: 634 YNDKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEV 693
YNDKQPILLKKI+EKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEV
Sbjct: 916 YNDKQPILLKKIVEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEV 975
Query: 694 AWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHA 753
AWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALG+MQMVEDTLIEHA
Sbjct: 976 AWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGVMQMVEDTLIEHA 1035
Query: 754 HTKPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQ 813
HTKPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQ
Sbjct: 1036 HTKPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQ 1095
Query: 814 IISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKS 873
IISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKS
Sbjct: 1096 IISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKS 1155
Query: 874 IEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTK 933
IEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTK
Sbjct: 1156 IEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTK 1215
Query: 934 EDIIKFYKEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQ 993
EDII+FYKEMLAV+APRRHKVSVHVLAREMDSCPVVGEFPCQND+NL+ APALPQPEVI+
Sbjct: 1216 EDIIRFYKEMLAVEAPRRHKVSVHVLAREMDSCPVVGEFPCQNDVNLAAAPALPQPEVIE 1275
Query: 994 NMTEFKRGLPLFPLVKPHINFMAAKL 1019
NMT FKR LPLFPLVKPHIN MAAKL
Sbjct: 1276 NMTAFKRSLPLFPLVKPHINLMAAKL 1301
>gb|EDL41785.1| insulin degrading enzyme [Mus musculus]
Length = 978
Score = 1933 bits (5007), Expect = 0.0, Method: Composition-based stats.
Identities = 941/978 (96%), Positives = 963/978 (98%)
Query: 42 MNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPP 101
M+NPAI+RI + I KSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPP
Sbjct: 1 MSNPAIQRIEDQIVKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPP 60
Query: 102 NIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGA 161
NI GLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGA
Sbjct: 61 NIPGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGA 120
Query: 162 LDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTG 221
LDRFAQFFLCPLFD SCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTG
Sbjct: 121 LDRFAQFFLCPLFDASCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTG 180
Query: 222 NKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENK 281
NKYTLETRPNQEGIDVR+ELLKFHS YYSSNLMA+CVLGRESLDDLTNLVVKLFSEVENK
Sbjct: 181 NKYTLETRPNQEGIDVREELLKFHSTYYSSNLMAICVLGRESLDDLTNLVVKLFSEVENK 240
Query: 282 NVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHE 341
NVPLPEFPEHPFQEEHL+QLYKIVPIKDIRNLYVTFPIPDLQ+YYKSNPGHYLGHLIGHE
Sbjct: 241 NVPLPEFPEHPFQEEHLRQLYKIVPIKDIRNLYVTFPIPDLQQYYKSNPGHYLGHLIGHE 300
Query: 342 GPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKL 401
GPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKL
Sbjct: 301 GPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKL 360
Query: 402 RAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRP 461
RAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAG LHYYPL VLTAEYLLEEFRP
Sbjct: 361 RAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGKLHYYPLNGVLTAEYLLEEFRP 420
Query: 462 DLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGK 521
DLI+MVLDKLRPENVRVAIVSKSFEGKTDRTE+WYGTQYKQEAIP+++I+KWQNADLNGK
Sbjct: 421 DLIDMVLDKLRPENVRVAIVSKSFEGKTDRTEQWYGTQYKQEAIPEDIIQKWQNADLNGK 480
Query: 522 FKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSP 581
FKLPTKNEFIPTNFEIL LEK+ATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSP
Sbjct: 481 FKLPTKNEFIPTNFEILSLEKDATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSP 540
Query: 582 FAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPIL 641
FAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPIL
Sbjct: 541 FAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPIL 600
Query: 642 LKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELK 701
LKKI EKMATFEID+KRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELK
Sbjct: 601 LKKITEKMATFEIDKKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELK 660
Query: 702 EALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPS 761
EALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALG+MQMVEDTLIEHAHTKPLLPS
Sbjct: 661 EALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGVMQMVEDTLIEHAHTKPLLPS 720
Query: 762 QLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFN 821
QLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFN
Sbjct: 721 QLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFN 780
Query: 822 TLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEA 881
TLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEK+IEDMTEEA
Sbjct: 781 TLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKAIEDMTEEA 840
Query: 882 FQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYK 941
FQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYN+DRDN EVAYLKTLTK+DII+FY+
Sbjct: 841 FQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNYDRDNIEVAYLKTLTKDDIIRFYQ 900
Query: 942 EMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRG 1001
EMLAVDAPRRHKVSVHVLAREMDSCPVVGEFP QNDINLS+AP LPQPEVI NMTEFKRG
Sbjct: 901 EMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPSQNDINLSEAPPLPQPEVIHNMTEFKRG 960
Query: 1002 LPLFPLVKPHINFMAAKL 1019
LPLFPLVKPHINFMAAKL
Sbjct: 961 LPLFPLVKPHINFMAAKL 978
>pdb|2WBY|A Chain A, Crystal Structure Of Human Insulin-Degrading Enzyme In
Complex With Insulin
pdb|2WBY|B Chain B, Crystal Structure Of Human Insulin-Degrading Enzyme In
Complex With Insulin
pdb|2WC0|A Chain A, Crystal Structure Of Human Insulin Degrading Enzyme In
Complex With Iodinated Insulin
pdb|2WC0|B Chain B, Crystal Structure Of Human Insulin Degrading Enzyme In
Complex With Iodinated Insulin
Length = 990
Score = 1932 bits (5005), Expect = 0.0, Method: Composition-based stats.
Identities = 964/978 (98%), Positives = 965/978 (98%)
Query: 42 MNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPP 101
MNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPP
Sbjct: 13 MNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPP 72
Query: 102 NIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGA 161
NIAGLSHF +HMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGA
Sbjct: 73 NIAGLSHFLQHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGA 132
Query: 162 LDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTG 221
LDRFAQFFL PLFDES KDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTG
Sbjct: 133 LDRFAQFFLSPLFDESAKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTG 192
Query: 222 NKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENK 281
NKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAV VLGRESLDDLTNLVVKLFSEVENK
Sbjct: 193 NKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVVVLGRESLDDLTNLVVKLFSEVENK 252
Query: 282 NVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHE 341
NVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHE
Sbjct: 253 NVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHE 312
Query: 342 GPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKL 401
GPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKL
Sbjct: 313 GPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKL 372
Query: 402 RAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRP 461
RAEGPQEWVFQE KDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRP
Sbjct: 373 RAEGPQEWVFQELKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRP 432
Query: 462 DLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGK 521
DLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGK
Sbjct: 433 DLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGK 492
Query: 522 FKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSP 581
FKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKA LNFEFFSP
Sbjct: 493 FKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKANLNFEFFSP 552
Query: 582 FAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPIL 641
FAYVDPLH NMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPIL
Sbjct: 553 FAYVDPLHSNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPIL 612
Query: 642 LKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELK 701
LKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELK
Sbjct: 613 LKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELK 672
Query: 702 EALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPS 761
EALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPS
Sbjct: 673 EALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPS 732
Query: 762 QLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFN 821
QLVRYREVQLPDRGWFVYQQRNEVHNN GIEIYYQTDMQSTSENMFLELF QIISEP FN
Sbjct: 733 QLVRYREVQLPDRGWFVYQQRNEVHNNSGIEIYYQTDMQSTSENMFLELFAQIISEPAFN 792
Query: 822 TLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEA 881
TLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEA
Sbjct: 793 TLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEA 852
Query: 882 FQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYK 941
FQKHIQALAIRRLDKPKKLSAE AKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYK
Sbjct: 853 FQKHIQALAIRRLDKPKKLSAESAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYK 912
Query: 942 EMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRG 1001
EMLAVDAPRRHKVSVHVLAREMDS PVVGEFP QNDINLSQAPALPQPEVIQNMTEFKRG
Sbjct: 913 EMLAVDAPRRHKVSVHVLAREMDSNPVVGEFPAQNDINLSQAPALPQPEVIQNMTEFKRG 972
Query: 1002 LPLFPLVKPHINFMAAKL 1019
LPLFPLVKPHINFMAAKL
Sbjct: 973 LPLFPLVKPHINFMAAKL 990
>dbj|BAF62161.1| insulin-degrading enzyme [Danio rerio]
Length = 998
Score = 1833 bits (4748), Expect = 0.0, Method: Composition-based stats.
Identities = 871/979 (88%), Positives = 936/979 (95%)
Query: 41 KMNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDP 100
+M++PA+KR+ + I +SPEDKREYRGLE NG+K +LISDPTTDKSSAALDVH+GSLSDP
Sbjct: 20 RMSDPAVKRVVSDIIRSPEDKREYRGLESTNGLKAILISDPTTDKSSAALDVHMGSLSDP 79
Query: 101 PNIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEG 160
NI+GL+HFCEHMLFLGT+KYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHL+G
Sbjct: 80 ENISGLAHFCEHMLFLGTEKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLQG 139
Query: 161 ALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGT 220
ALDRFAQFFLCPLFDESCKDREVNAVDSEHEKN+MNDAWRLFQLEKATGNPKHPFSKFGT
Sbjct: 140 ALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNLMNDAWRLFQLEKATGNPKHPFSKFGT 199
Query: 221 GNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVEN 280
GNK TLETRP+Q+GID+R+ELLKFHS YYSSNLM +CVLGRE+LD+LT++VVKLF EVEN
Sbjct: 200 GNKLTLETRPSQQGIDIREELLKFHSTYYSSNLMGLCVLGRETLDELTSMVVKLFGEVEN 259
Query: 281 KNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGH 340
KNVP+PEFP HPFQEEHL+Q YK+VPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGH
Sbjct: 260 KNVPVPEFPTHPFQEEHLRQFYKVVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGH 319
Query: 341 EGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQK 400
EGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDII HMFQYIQK
Sbjct: 320 EGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIIFHMFQYIQK 379
Query: 401 LRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFR 460
LR EGPQEWVFQECKDLN VAFRFKDKERPRGYTSK+AG+LHYYPLEE+L AEYLLEEFR
Sbjct: 380 LRTEGPQEWVFQECKDLNTVAFRFKDKERPRGYTSKVAGLLHYYPLEEILAAEYLLEEFR 439
Query: 461 PDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNG 520
PDLIEMVLDKLRPENVRVA+VSKSFEG+TDRTEEWYGTQYKQEAI DE IKKW NADLNG
Sbjct: 440 PDLIEMVLDKLRPENVRVAVVSKSFEGQTDRTEEWYGTQYKQEAITDEAIKKWDNADLNG 499
Query: 521 KFKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFS 580
KFKLP KNEFIPTNFEI PLEK++ P LIKDTAMSK+WFKQDDKFFLPKACLNFEFFS
Sbjct: 500 KFKLPMKNEFIPTNFEIYPLEKDSPSAPTLIKDTAMSKVWFKQDDKFFLPKACLNFEFFS 559
Query: 581 PFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPI 640
PFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNT+YGMYLSVKGYNDKQ I
Sbjct: 560 PFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTVYGMYLSVKGYNDKQHI 619
Query: 641 LLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDEL 700
LLKKIIEKMATFEIDEKRF+IIKEAYMR LNNFRAEQPHQHAMYYLRLLMTEVAWTKDEL
Sbjct: 620 LLKKIIEKMATFEIDEKRFDIIKEAYMRPLNNFRAEQPHQHAMYYLRLLMTEVAWTKDEL 679
Query: 701 KEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLP 760
++ALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQ+AL +MQM+EDTLIEHAHTKPLLP
Sbjct: 680 RDALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQSALEMMQMLEDTLIEHAHTKPLLP 739
Query: 761 SQLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCF 820
SQL+RYREVQ+PD GW+VYQQRNEVHNNCGIEIYYQTDMQ+T ENM LELFCQIISEPCF
Sbjct: 740 SQLIRYREVQVPDGGWYVYQQRNEVHNNCGIEIYYQTDMQNTHENMLLELFCQIISEPCF 799
Query: 821 NTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEE 880
NTLRTKEQLGYIVFSGPRRANG+QGLRFIIQSEK PHYLESRVEAFL TMEKS+E+M +E
Sbjct: 800 NTLRTKEQLGYIVFSGPRRANGVQGLRFIIQSEKAPHYLESRVEAFLKTMEKSVEEMGDE 859
Query: 881 AFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFY 940
AFQKHIQALAIRRLDKPKKL+AECAKYWGEIISQQYNFDRDN EVAYLKTLTKE I++FY
Sbjct: 860 AFQKHIQALAIRRLDKPKKLAAECAKYWGEIISQQYNFDRDNIEVAYLKTLTKEHIMQFY 919
Query: 941 KEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKR 1000
+++LA+DAPRRHKVSVHVL+REMDSCP+VGEFP QND+NL+ AP+LPQP ++Q+MTEFKR
Sbjct: 920 RDLLAIDAPRRHKVSVHVLSREMDSCPLVGEFPAQNDVNLAPAPSLPQPSLVQDMTEFKR 979
Query: 1001 GLPLFPLVKPHINFMAAKL 1019
LPLFPL KPHINFMAA L
Sbjct: 980 SLPLFPLTKPHINFMAANL 998
>ref|NP_001082994.1| insulin-degrading enzyme [Danio rerio]
gb|AAI39608.1| Zgc:162603 protein [Danio rerio]
Length = 978
Score = 1831 bits (4742), Expect = 0.0, Method: Composition-based stats.
Identities = 873/978 (89%), Positives = 937/978 (95%)
Query: 42 MNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPP 101
M++PA+KR+ + I +SPEDKREYRGLE NG+K +LISDPTTDKSSAALDVH+GSLSDP
Sbjct: 1 MSDPAVKRVVSDIIRSPEDKREYRGLEFTNGLKAILISDPTTDKSSAALDVHMGSLSDPE 60
Query: 102 NIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGA 161
NI+GL+HFCEHMLFLGT+KYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHL+GA
Sbjct: 61 NISGLAHFCEHMLFLGTEKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLQGA 120
Query: 162 LDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTG 221
LDRFAQFFLCPLFDESCKDREVNAVDSEHEKN+MNDAWRLFQLEKATGNPKHPFSKFGTG
Sbjct: 121 LDRFAQFFLCPLFDESCKDREVNAVDSEHEKNLMNDAWRLFQLEKATGNPKHPFSKFGTG 180
Query: 222 NKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENK 281
NK TLETRP+Q+GID+R+ELLKFHS YYSSNLM +CVLGRE+LD+LT++VVKLF EVENK
Sbjct: 181 NKLTLETRPSQQGIDIREELLKFHSTYYSSNLMGLCVLGRETLDELTSMVVKLFGEVENK 240
Query: 282 NVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHE 341
NVP+PEFP HPFQEEHL+Q YK+VPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHE
Sbjct: 241 NVPVPEFPTHPFQEEHLRQFYKVVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHE 300
Query: 342 GPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKL 401
GPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDII HMFQYIQKL
Sbjct: 301 GPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIIFHMFQYIQKL 360
Query: 402 RAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRP 461
R EGPQEWVFQECKDLN VAFRFKDKERPRGYTSK+AG+LHYYPLEE+L AEYLLEEFRP
Sbjct: 361 RTEGPQEWVFQECKDLNTVAFRFKDKERPRGYTSKVAGLLHYYPLEEILAAEYLLEEFRP 420
Query: 462 DLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGK 521
DLIEMVLDKLRPENVRVA+VSKSFEG+TDRTEEWYGTQYKQEAI DE IKKW NADLNGK
Sbjct: 421 DLIEMVLDKLRPENVRVAVVSKSFEGQTDRTEEWYGTQYKQEAITDEAIKKWDNADLNGK 480
Query: 522 FKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSP 581
FKLP KNEFIPTNFEI PLEK++ P LIKDTAMSK+WFKQDDKFFLPKACLNFEFFSP
Sbjct: 481 FKLPMKNEFIPTNFEIYPLEKDSPSAPTLIKDTAMSKVWFKQDDKFFLPKACLNFEFFSP 540
Query: 582 FAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPIL 641
FAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNT+YGMYLSVKGYNDKQ IL
Sbjct: 541 FAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTVYGMYLSVKGYNDKQHIL 600
Query: 642 LKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELK 701
LKKIIEKMATFEIDEKRF+IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDEL+
Sbjct: 601 LKKIIEKMATFEIDEKRFDIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELR 660
Query: 702 EALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPS 761
+ALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQ+AL +MQM+EDTLIEHAHTKPLLPS
Sbjct: 661 DALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQSALEMMQMLEDTLIEHAHTKPLLPS 720
Query: 762 QLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFN 821
QL+RYREVQ+PD GW+VYQQRNEVHNNCGIEIYYQTDMQ+T ENM LELFCQIISEPCFN
Sbjct: 721 QLIRYREVQVPDGGWYVYQQRNEVHNNCGIEIYYQTDMQNTHENMLLELFCQIISEPCFN 780
Query: 822 TLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEA 881
TLRTKEQLGYIVFSGPRRANG+QGLRFIIQSEK PHYLESRVEAFL TMEKS+E+M +EA
Sbjct: 781 TLRTKEQLGYIVFSGPRRANGVQGLRFIIQSEKAPHYLESRVEAFLKTMEKSVEEMGDEA 840
Query: 882 FQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYK 941
FQKHIQALAIRRLDKPKKL+AECAKYWGEIISQQYNFDRDN EVAYLKTLTKE I++FY+
Sbjct: 841 FQKHIQALAIRRLDKPKKLAAECAKYWGEIISQQYNFDRDNIEVAYLKTLTKEHIMQFYR 900
Query: 942 EMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRG 1001
++LA+DAPRRHKVSVHVL+REMDSCP+VGEFP QND+NL+ AP+LPQP ++Q+MTEFKR
Sbjct: 901 DLLAIDAPRRHKVSVHVLSREMDSCPLVGEFPAQNDVNLAPAPSLPQPSLVQDMTEFKRS 960
Query: 1002 LPLFPLVKPHINFMAAKL 1019
LPLFPL KPHINFMAAKL
Sbjct: 961 LPLFPLTKPHINFMAAKL 978
>ref|XP_001146439.1| PREDICTED: insulysin isoform 1 [Pan troglodytes]
Length = 861
Score = 1742 bits (4512), Expect = 0.0, Method: Composition-based stats.
Identities = 856/856 (100%), Positives = 856/856 (100%)
Query: 164 RFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNK 223
RFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNK
Sbjct: 6 RFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNK 65
Query: 224 YTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNV 283
YTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNV
Sbjct: 66 YTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNV 125
Query: 284 PLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGP 343
PLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGP
Sbjct: 126 PLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGP 185
Query: 344 GSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRA 403
GSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRA
Sbjct: 186 GSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRA 245
Query: 404 EGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDL 463
EGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDL
Sbjct: 246 EGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDL 305
Query: 464 IEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFK 523
IEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFK
Sbjct: 306 IEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFK 365
Query: 524 LPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFA 583
LPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFA
Sbjct: 366 LPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFA 425
Query: 584 YVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLK 643
YVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLK
Sbjct: 426 YVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLK 485
Query: 644 KIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEA 703
KIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEA
Sbjct: 486 KIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEA 545
Query: 704 LDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQL 763
LDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQL
Sbjct: 546 LDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQL 605
Query: 764 VRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTL 823
VRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTL
Sbjct: 606 VRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTL 665
Query: 824 RTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQ 883
RTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQ
Sbjct: 666 RTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQ 725
Query: 884 KHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEM 943
KHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEM
Sbjct: 726 KHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEM 785
Query: 944 LAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLP 1003
LAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLP
Sbjct: 786 LAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLP 845
Query: 1004 LFPLVKPHINFMAAKL 1019
LFPLVKPHINFMAAKL
Sbjct: 846 LFPLVKPHINFMAAKL 861
>ref|XP_001090017.1| PREDICTED: insulysin isoform 1 [Macaca mulatta]
Length = 861
Score = 1736 bits (4495), Expect = 0.0, Method: Composition-based stats.
Identities = 852/856 (99%), Positives = 855/856 (99%)
Query: 164 RFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNK 223
RFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNK
Sbjct: 6 RFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNK 65
Query: 224 YTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNV 283
YTLETRPNQEGIDVRQELLKFHS YYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENK+V
Sbjct: 66 YTLETRPNQEGIDVRQELLKFHSTYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKSV 125
Query: 284 PLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGP 343
PLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGP
Sbjct: 126 PLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGP 185
Query: 344 GSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRA 403
GSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRA
Sbjct: 186 GSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRA 245
Query: 404 EGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDL 463
EGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDL
Sbjct: 246 EGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDL 305
Query: 464 IEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFK 523
IEMVLDKLRPENVRVA+VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFK
Sbjct: 306 IEMVLDKLRPENVRVAVVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFK 365
Query: 524 LPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFA 583
LPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFA
Sbjct: 366 LPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFA 425
Query: 584 YVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLK 643
YVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLK
Sbjct: 426 YVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLK 485
Query: 644 KIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEA 703
KIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEA
Sbjct: 486 KIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEA 545
Query: 704 LDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQL 763
LDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQL
Sbjct: 546 LDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQL 605
Query: 764 VRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTL 823
VRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTL
Sbjct: 606 VRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTL 665
Query: 824 RTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQ 883
RTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQ
Sbjct: 666 RTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQ 725
Query: 884 KHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEM 943
KHIQALAIRRLDKPKKLSAECAKYWGEIISQQY+FDRDNTEVAYLKTLTKEDIIKFYKEM
Sbjct: 726 KHIQALAIRRLDKPKKLSAECAKYWGEIISQQYHFDRDNTEVAYLKTLTKEDIIKFYKEM 785
Query: 944 LAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLP 1003
LAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLP
Sbjct: 786 LAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLP 845
Query: 1004 LFPLVKPHINFMAAKL 1019
LFPLVKPHINFMAAKL
Sbjct: 846 LFPLVKPHINFMAAKL 861
>dbj|BAD92441.1| insulysin variant [Homo sapiens]
Length = 594
Score = 1199 bits (3102), Expect = 0.0, Method: Composition-based stats.
Identities = 593/594 (99%), Positives = 593/594 (99%)
Query: 426 DKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAIVSKSF 485
DKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAIVSK F
Sbjct: 1 DKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAIVSKCF 60
Query: 486 EGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPLEKEAT 545
EGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPLEKEAT
Sbjct: 61 EGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPLEKEAT 120
Query: 546 PYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELLKDSLN 605
PYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELLKDSLN
Sbjct: 121 PYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELLKDSLN 180
Query: 606 EYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFEIIKEA 665
EYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFEIIKEA
Sbjct: 181 EYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFEIIKEA 240
Query: 666 YMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHI 725
YMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHI
Sbjct: 241 YMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHI 300
Query: 726 EALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQRNEV 785
EALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQRNEV
Sbjct: 301 EALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQRNEV 360
Query: 786 HNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRANGIQG 845
HNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRANGIQG
Sbjct: 361 HNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRANGIQG 420
Query: 846 LRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKLSAECA 905
LRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKLSAECA
Sbjct: 421 LRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKLSAECA 480
Query: 906 KYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLAREMDS 965
KYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLAREMDS
Sbjct: 481 KYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLAREMDS 540
Query: 966 CPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL 1019
CPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL
Sbjct: 541 CPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL 594
>ref|XP_001629798.1| predicted protein [Nematostella vectensis]
gb|EDO37735.1| predicted protein [Nematostella vectensis]
Length = 947
Score = 1184 bits (3064), Expect = 0.0, Method: Composition-based stats.
Identities = 557/914 (60%), Positives = 708/914 (77%), Gaps = 16/914 (1%)
Query: 46 AIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAG 105
+K + I KSP+D R+YRGL L NG+KVLLI D +TDKS+AA+DVHIGSL+DP + G
Sbjct: 3 GVKEVHKDIPKSPQDDRDYRGLLLENGLKVLLIHDSSTDKSAAAMDVHIGSLTDPKELPG 62
Query: 106 LSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRF 165
L+HFCEHMLFLGT+KYP EN Y+QFL+E+ GSSNAFTSGEHTNY+FDV +E L ALDRF
Sbjct: 63 LAHFCEHMLFLGTEKYPGENAYTQFLTENGGSSNAFTSGEHTNYFFDVKYESLSNALDRF 122
Query: 166 AQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYT 225
AQFFLCPLF+ KDREVNAVDSE+ KN +ND WRL QL+K+T +P HP++KF TGNK T
Sbjct: 123 AQFFLCPLFNADAKDREVNAVDSENSKNRLNDMWRLNQLDKSTVDPSHPYNKFCTGNKLT 182
Query: 226 LETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPL 285
L+TRP ++GID R+ELLKFHS YYS+N+M++ V+GRESLD++T +VVKLFS V+NKNV +
Sbjct: 183 LDTRPKEKGIDTREELLKFHSLYYSANIMSLSVIGRESLDEMTEMVVKLFSPVQNKNVTI 242
Query: 286 PEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGS 345
P FPEHP+ E ++ L+K+VP+KD++NL + FPIPD+ KYY P HY+ HLIGHEG GS
Sbjct: 243 PTFPEHPYGAEQVQTLFKVVPVKDMKNLNLMFPIPDMSKYYHFKPSHYISHLIGHEGEGS 302
Query: 346 LLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEG 405
LLSELK+KGWVN LV G +GA+GFMFF+ N++LT EG H+ +I +FQY++ LR E
Sbjct: 303 LLSELKAKGWVNALVAGALDGAKGFMFFMCNMELTNEGQDHIFEISTSVFQYLEMLRREE 362
Query: 406 PQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIE 465
P EWVF+ECK L V FRF DKE PR Y +A LH + +++VL +LL FRPDLI+
Sbjct: 363 PFEWVFEECKALAEVRFRFNDKETPRSYVCHLARSLHDFSIDDVLRGPHLLTSFRPDLIK 422
Query: 466 MVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLP 525
VLD L PE VR+ IVSK+FEGKTD+TEEWYGT+Y E I + IK W+N LN +P
Sbjct: 423 QVLDNLVPEKVRITIVSKAFEGKTDKTEEWYGTEYSMERIDQQQIKDWKNVSLNAALTIP 482
Query: 526 TKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYV 585
KNEFIPT+ +I P E +P ++K+WFKQD F LPKAC+ FE SP AY+
Sbjct: 483 KKNEFIPTDLDIRPAPGEDSP---------LTKVWFKQDVTFLLPKACMLFEITSPLAYI 533
Query: 586 DPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKI 645
DP HCNMAY++L+LLKDSLNEYAY AE+AG++Y+L NT+YG+++S++GYN KQ IL++KI
Sbjct: 534 DPCHCNMAYIFLQLLKDSLNEYAYDAEIAGVTYNLDNTMYGIFMSIRGYNHKQGILMEKI 593
Query: 646 IEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALD 705
+++M F++D RF +IKE Y + L NF+AEQPHQHA+YY L+ E+AW KDEL +AL+
Sbjct: 594 LKRMTKFKVDPNRFRLIKERYEQGLRNFKAEQPHQHALYYTSYLLEELAWHKDELIDALE 653
Query: 706 DVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVR 765
+VT+ +L+AFIPQLL RLHIE LLHGN+T++ ALG++ +E E++ TKPLLP QL R
Sbjct: 654 EVTIEKLQAFIPQLLGRLHIECLLHGNVTEKEALGLVDTMESIFTENSGTKPLLPLQLRR 713
Query: 766 YREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRT 825
+RE+QLP N VH+N IEIYYQ D+Q T NM LELFCQ+I E CFN LRT
Sbjct: 714 HREIQLP-------HTVNHVHSNSSIEIYYQCDLQETRSNMLLELFCQVIHESCFNILRT 766
Query: 826 KEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKH 885
+EQLGYIVFSGPRR NG QGLRFIIQS+K P L+SRVE FL ++ IE MT+E F+ H
Sbjct: 767 QEQLGYIVFSGPRRGNGAQGLRFIIQSDKEPSLLDSRVEVFLDKTKEMIESMTDEEFKNH 826
Query: 886 IQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLA 945
I ALA+RRLDKPKKL E K+WGEI+++QYNFDRDN EVA+L+TLTK+D++ FYK++L
Sbjct: 827 IDALAVRRLDKPKKLRTETQKHWGEILTRQYNFDRDNVEVAFLRTLTKDDLLNFYKDLLE 886
Query: 946 VDAPRRHKVSVHVL 959
APRRHK++VH+L
Sbjct: 887 PSAPRRHKLAVHIL 900
>gb|EAW50092.1| insulin-degrading enzyme, isoform CRA_b [Homo sapiens]
Length = 568
Score = 1114 bits (2882), Expect = 0.0, Method: Composition-based stats.
Identities = 539/539 (100%), Positives = 539/539 (100%)
Query: 42 MNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPP 101
MNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPP
Sbjct: 1 MNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPP 60
Query: 102 NIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGA 161
NIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGA
Sbjct: 61 NIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGA 120
Query: 162 LDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTG 221
LDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTG
Sbjct: 121 LDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTG 180
Query: 222 NKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENK 281
NKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENK
Sbjct: 181 NKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENK 240
Query: 282 NVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHE 341
NVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHE
Sbjct: 241 NVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHE 300
Query: 342 GPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKL 401
GPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKL
Sbjct: 301 GPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKL 360
Query: 402 RAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRP 461
RAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRP
Sbjct: 361 RAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRP 420
Query: 462 DLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGK 521
DLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGK
Sbjct: 421 DLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGK 480
Query: 522 FKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFS 580
FKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFS
Sbjct: 481 FKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFS 539
>ref|XP_971897.1| PREDICTED: similar to Insulin-degrading enzyme (Insulysin)
(Insulinase) (Insulin protease) [Tribolium castaneum]
Length = 977
Score = 1099 bits (2842), Expect = 0.0, Method: Composition-based stats.
Identities = 523/970 (53%), Positives = 718/970 (74%), Gaps = 8/970 (0%)
Query: 44 NPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNI 103
N ++R+ N I KS EDKR YRGLELAN +KVLL+SDPTTDKS+AA+DV++G +SDP ++
Sbjct: 6 NLVLRRVEN-IIKSQEDKRLYRGLELANHMKVLLVSDPTTDKSAAAMDVNVGFMSDPRDV 64
Query: 104 AGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALD 163
GL+HFCEHMLFLGTKKYP EN+Y+++LSEH GSSNA T +HT YYFD+ + L ALD
Sbjct: 65 YGLAHFCEHMLFLGTKKYPNENDYNKYLSEHGGSSNAATYPDHTIYYFDIVPDELNNALD 124
Query: 164 RFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNK 223
RF+QFF+ PLF ES DRE+NAV+SEHEKN+ ND WR QL+K +PKHP+ FGTGN+
Sbjct: 125 RFSQFFIAPLFTESATDREMNAVNSEHEKNIPNDVWRKDQLDKHLADPKHPYHTFGTGNR 184
Query: 224 YTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNV 283
+TL+T P ++ I+VR ELLKFH +YSSN+M + VLG+ESLDDL +VVKLFSEV++K +
Sbjct: 185 HTLDTLPKEKNINVRDELLKFHDKWYSSNIMCLAVLGKESLDDLEQMVVKLFSEVKDKAI 244
Query: 284 PLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGP 343
P + EHPF++EH + PIKD+RNL + FP DLQ+YYKS+P HY+ HL+GHEGP
Sbjct: 245 AAPRWEEHPFKDEHFGTCVYMYPIKDVRNLNIVFPCRDLQEYYKSSPSHYISHLMGHEGP 304
Query: 344 GSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRA 403
GS+LS LK++GW N LV G + RG FF + VDLTEEG+ H++DI+ +FQY+ L+
Sbjct: 305 GSILSTLKARGWSNNLVAGSRPAPRGLGFFGVTVDLTEEGIKHIDDIVELIFQYLNMLKR 364
Query: 404 EGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDL 463
+GPQ+WV E +D+ + FRFKDKE PR Y + + L Y +E+VL+ YL E+RPD+
Sbjct: 365 QGPQKWVQDENRDIGNMLFRFKDKESPRSYIAGLVHTLQDYSMEDVLSCMYLFSEWRPDI 424
Query: 464 IEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFK 523
IE V + PE +R+ +++K +E + D+ E WYGT+YK IP++ +++W+ ++L+G FK
Sbjct: 425 IEQVWNDFVPEKIRIVVLAKQYENELDQVEPWYGTKYKVAKIPEKTLERWRKSELSGDFK 484
Query: 524 LPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFA 583
LP KNEFIPT+FE+ P++KE T +P +I+DTA++++WFKQD+ F LPKA + F+F SP A
Sbjct: 485 LPEKNEFIPTDFELYPIDKEVTEHPVIIQDTALTRVWFKQDETFLLPKANVMFDFVSPLA 544
Query: 584 YVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLK 643
Y+DPL+CN+ ++ ++L +D+LNEYAYAAELAGL ++L NT YG+ L++ GY++KQ I L
Sbjct: 545 YLDPLNCNLTHMLVQLFRDALNEYAYAAELAGLKWELINTKYGLILAIGGYSNKQHIFLD 604
Query: 644 KIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEA 703
K++EK+ F+ID KRFEI KE Y+R+L NF AEQP+QHA+YYL L+TE +WTK EL
Sbjct: 605 KVMEKLTNFKIDPKRFEICKENYIRNLKNFAAEQPYQHAVYYLAALLTEHSWTKQELLAT 664
Query: 704 LDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQL 763
+ +T+ +L+AFIPQ+LS++HIE L+HGN K+ AL ++Q+VED L+ + PLLP QL
Sbjct: 665 TEQLTIDKLEAFIPQILSKMHIECLIHGNANKEKALQLVQIVEDRLLSTLNMSPLLPRQL 724
Query: 764 VRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTL 823
+ RE++L D +VY+ +NEVH IE+YYQ +QS NM LELF QI+ EPCF+ L
Sbjct: 725 LLNRELKLEDGCNYVYEVQNEVHKESCIELYYQCGLQSKENNMKLELFAQIVQEPCFDIL 784
Query: 824 RTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQ 883
RTKEQLGYIVFSG RR+NG+QGLR I+QS+K P L+ R+E FL M +++M+EE F
Sbjct: 785 RTKEQLGYIVFSGIRRSNGVQGLRIIVQSDKHPVRLDERIEEFLKNMLSYLKNMSEEEFA 844
Query: 884 KHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEM 943
+H +ALA +RL+KPK+LS + +WGEI SQQY+FDR N EVAYL+TLTKEDII FYK +
Sbjct: 845 RHREALAAQRLEKPKQLSTQTNIFWGEITSQQYHFDRANVEVAYLRTLTKEDIIDFYKSL 904
Query: 944 LAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLP 1003
L +A R K+SVHV++ + + ++ + V+ ++T FK
Sbjct: 905 LEENAQFRKKLSVHVVSMADGGAGKMAASDKEYTVD-------SKGTVVCDITVFKSSHE 957
Query: 1004 LFPLVKPHIN 1013
+ PLV+P+IN
Sbjct: 958 MHPLVQPYIN 967
>ref|XP_001603463.1| PREDICTED: similar to metalloprotease [Nasonia vitripennis]
Length = 999
Score = 1088 bits (2815), Expect = 0.0, Method: Composition-based stats.
Identities = 524/982 (53%), Positives = 712/982 (72%), Gaps = 6/982 (0%)
Query: 36 KKTYSKMNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIG 95
KK+ +K + R N+I KSP DKR+YRGL L N +KVLLISDP TDKS+A+LDV++G
Sbjct: 8 KKSITKHQSKEPTRY-NNIVKSPNDKRDYRGLILHNKLKVLLISDPMTDKSAASLDVNVG 66
Query: 96 SLSDPPNIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSH 155
LSDP + GL+HFCEHMLFLGT KYP+ N+Y+Q+LS++ G+SNA T +HTNYYFDV+
Sbjct: 67 YLSDPKELPGLAHFCEHMLFLGTTKYPEVNDYNQYLSQNGGASNAATYLDHTNYYFDVNP 126
Query: 156 EHLEGALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPF 215
+ LEGALDRF+QFF+ PLF ES ++E+ AV EHEKN+ ND WR+ QL+K++ +P H +
Sbjct: 127 DKLEGALDRFSQFFVSPLFTESATEKEITAVHLEHEKNIANDTWRMDQLDKSSADPSHAY 186
Query: 216 SKFGTGNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLF 275
SKFGTG+K TLE P Q+ IDVRQELL FH+ +YS+N+MA+ VLG+ESLDDL ++V +F
Sbjct: 187 SKFGTGSKDTLEVIPKQKNIDVRQELLNFHNTWYSANIMALSVLGKESLDDLEKMIVDMF 246
Query: 276 SEVENKNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLG 335
S+++NKNV +P++P HPF +EH K + IVPIKDIRNL +TFPIPD+Q+++++ P HY
Sbjct: 247 SDIDNKNVEVPKWPAHPFTDEHFKTKWFIVPIKDIRNLNITFPIPDMQEHFRAAPVHYWS 306
Query: 336 HLIGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMF 395
HL+GHEG GSLLS LK KGW N+LV G++ ARGF FF + VDLTEEG+LHV+DI+ F
Sbjct: 307 HLLGHEGKGSLLSTLKEKGWCNSLVSGKRSSARGFDFFSVYVDLTEEGILHVDDIVTMTF 366
Query: 396 QYIQKLRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYL 455
QYI L+ EGP EW+F+E D+ + FRFK+K PR Y + L YP+EEVL+A L
Sbjct: 367 QYINMLKNEGPVEWIFEEYSDIAKMNFRFKEKASPRSYVNVTVQSLQDYPIEEVLSASRL 426
Query: 456 LEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQN 515
++RPDLI + + L PE +RV +V+K++E D E WYGT+YK+E IP+++I++W N
Sbjct: 427 FTQWRPDLINELNNYLVPEKIRVQVVAKAYEANADSVEPWYGTKYKKEKIPEDLIQRWNN 486
Query: 516 ADLNGKFKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLN 575
A + F+LP KNEFIPT F+I +EK A +P +I+D + WFKQDD+F LPKA +
Sbjct: 487 AGTDEAFQLPEKNEFIPTKFDIKSIEK-AEKFPTIIEDNPFIRTWFKQDDEFLLPKATMT 545
Query: 576 FEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYN 635
F+F SP Y+DP+ NM Y++++L +DSLNEYAY+A+LAGL ++L ++ YG+ L + GY+
Sbjct: 546 FDFVSPLTYIDPISSNMTYMFVQLFRDSLNEYAYSADLAGLKWELSHSKYGLSLIIAGYD 605
Query: 636 DKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAW 695
K +LL KI+++M F ID+KRF I+KE Y+R L NF AEQP+QHA YYL LM+E W
Sbjct: 606 HKLVVLLNKILDRMVNFTIDDKRFAILKENYIRGLKNFEAEQPYQHAAYYLAALMSEQVW 665
Query: 696 TKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHT 755
K+EL A +T R++ FIP L+S++HIE L+HGNITK AL ++ VE LI
Sbjct: 666 VKNELLNACSMLTADRVRQFIPLLMSKMHIECLIHGNITKAEALKTVKNVESKLISSVKD 725
Query: 756 -KPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQI 814
PLLP QLV YRE++LP+ ++Y+ N+ H + +IYYQ+ MQST NM LELF QI
Sbjct: 726 LTPLLPKQLVLYRELELPNGCHYLYEVDNKHHKSSCTQIYYQSGMQSTESNMLLELFTQI 785
Query: 815 ISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSI 874
ISEPCFN LRTKEQLGYIVFSG RR NG+QGLR I+QS K P ++E R++AF+ +M+ I
Sbjct: 786 ISEPCFNILRTKEQLGYIVFSGIRRTNGVQGLRIIVQSNKHPQFVEERIDAFMESMKDYI 845
Query: 875 EDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKE 934
+M++E F +H ++LA +RL+KPK L+++ YW EI QQYNFDR N EVAYLKT+++
Sbjct: 846 TNMSDEEFNRHKESLATQRLEKPKMLTSQSGIYWNEISMQQYNFDRANVEVAYLKTISRS 905
Query: 935 DIIKFYKEMLAVDAPRRHKVSVHVLAREMDSCP---VVGEFPCQNDINLSQAPALPQPEV 991
II FYK+++ ++P+RHK+S+HV++ V P + + A QP
Sbjct: 906 QIIDFYKDVVHSESPQRHKLSIHVVSTAEGGAAAEDVTSSTPSAEETKKTLEQAEQQPAR 965
Query: 992 IQNMTEFKRGLPLFPLVKPHIN 1013
IQ++ +FK PL+PLVKP N
Sbjct: 966 IQDILQFKTSHPLYPLVKPFNN 987
>ref|XP_421686.2| PREDICTED: similar to insulin-degrading enzyme [Gallus gallus]
Length = 948
Score = 1006 bits (2600), Expect = 0.0, Method: Composition-based stats.
Identities = 485/550 (88%), Positives = 503/550 (91%), Gaps = 27/550 (4%)
Query: 30 RLCGFQKKTYSKMNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAA 89
R QK+T +KMNNPAIKRI N I KSPEDKREYRGLELANGIK LLISDPTTDKSSAA
Sbjct: 127 RFFALQKETNNKMNNPAIKRITNEIIKSPEDKREYRGLELANGIKALLISDPTTDKSSAA 186
Query: 90 LDVHIGSLSDPPNIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNY 149
LDVHIGSLSDPPNIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNY
Sbjct: 187 LDVHIGSLSDPPNIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNY 246
Query: 150 YFDVSHEHLEGALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATG 209
YFDVSHEHLEGALDRFAQFFLCPLFDESCKDREVNAVDSEHEKN+MNDAWRLFQLEKATG
Sbjct: 247 YFDVSHEHLEGALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNLMNDAWRLFQLEKATG 306
Query: 210 NPKHPFSKFGTGNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTN 269
NP HPFSKFGTGNK TLETRP +EGIDVRQELLKFHS YYSSNLMA+CVLGRESLD+LT+
Sbjct: 307 NPNHPFSKFGTGNKLTLETRPTKEGIDVRQELLKFHSTYYSSNLMAICVLGRESLDELTS 366
Query: 270 LVVKLFSEVENKNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSN 329
LVVKLFSEVENKNVP+PEFPEHPFQEEHL+QLYK+VPIKDIRNLYVTFPIPDLQKYYKSN
Sbjct: 367 LVVKLFSEVENKNVPVPEFPEHPFQEEHLRQLYKVVPIKDIRNLYVTFPIPDLQKYYKSN 426
Query: 330 PGHYLGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVED 389
PGHYLGHLIGHEGPGSLLSELK+KGWV TLVGGQKEGARGFMFFIINVDLTEEGLLHVED
Sbjct: 427 PGHYLGHLIGHEGPGSLLSELKAKGWVYTLVGGQKEGARGFMFFIINVDLTEEGLLHVED 486
Query: 390 IILHMFQYIQKLRAEGPQEWVFQECKDLNAVAF--------------------------- 422
IILHMFQYIQKLR EGPQEWVFQECKDLNAVAF
Sbjct: 487 IILHMFQYIQKLRIEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKLGGMLHDLNAVAV 546
Query: 423 RFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAIVS 482
RFKDKERPRGYTSK+ G+LHYYP+EEVL AEYLLEEFRPDLIEMVLDKLRPEN+RVAIVS
Sbjct: 547 RFKDKERPRGYTSKLGGMLHYYPIEEVLAAEYLLEEFRPDLIEMVLDKLRPENIRVAIVS 606
Query: 483 KSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPLEK 542
KSFEGKTDRTE+WYGTQYKQEAI DEVIKKWQNADLNGKFKLP KNEFIPTNFEILPLEK
Sbjct: 607 KSFEGKTDRTEDWYGTQYKQEAISDEVIKKWQNADLNGKFKLPMKNEFIPTNFEILPLEK 666
Query: 543 EATPYPALIK 552
+AT YPAL+K
Sbjct: 667 DATQYPALVK 676
Score = 473 bits (1216), Expect = e-131, Method: Composition-based stats.
Identities = 234/252 (92%), Positives = 240/252 (95%)
Query: 768 EVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKE 827
E Q RGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKE
Sbjct: 697 EKQHASRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKE 756
Query: 828 QLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQ 887
QLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFL TMEK IEDMTEEAFQKHIQ
Sbjct: 757 QLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLKTMEKCIEDMTEEAFQKHIQ 816
Query: 888 ALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVD 947
ALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDN EVAYLKTLTK+DII+FYK +LAVD
Sbjct: 817 ALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNIEVAYLKTLTKDDIIQFYKVLLAVD 876
Query: 948 APRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPL 1007
APRRHKVSVHVLAREMDSCPVVGEFPCQND+NL+ AP LPQP VI+NMTEFKR LPLFPL
Sbjct: 877 APRRHKVSVHVLAREMDSCPVVGEFPCQNDVNLAPAPPLPQPSVIENMTEFKRSLPLFPL 936
Query: 1008 VKPHINFMAAKL 1019
VKPHINFMAAKL
Sbjct: 937 VKPHINFMAAKL 948
>ref|XP_001847597.1| metalloprotease [Culex pipiens quinquefasciatus]
gb|EDS26498.1| metalloprotease [Culex pipiens quinquefasciatus]
Length = 998
Score = 1001 bits (2588), Expect = 0.0, Method: Composition-based stats.
Identities = 484/963 (50%), Positives = 678/963 (70%), Gaps = 1/963 (0%)
Query: 52 NHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCE 111
+ I KS +D R YRGL L+NG+KVLLISDPTTDKS+AAL V +G LSDP I GL+HFCE
Sbjct: 26 DDIVKSQQDNRLYRGLRLSNGLKVLLISDPTTDKSAAALAVEVGHLSDPDEIPGLAHFCE 85
Query: 112 HMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLC 171
HMLFLGTKKY EN+Y FLSE+ GSSNA T + T YYFDV E L+ ALDRF+QFF+
Sbjct: 86 HMLFLGTKKYINENDYMAFLSENGGSSNAATYADTTKYYFDVVPEKLQEALDRFSQFFIA 145
Query: 172 PLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPN 231
PLF ES +RE+NAV SEHEKN+ D WR+ Q+ K+ +PKHP++KFGTG+K TL P
Sbjct: 146 PLFTESATEREINAVHSEHEKNLSMDVWRIRQVNKSLCDPKHPYNKFGTGSKKTLLEDPK 205
Query: 232 QEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEH 291
I++R+EL+KFHS +YS+N+M++ V G+ESLD+L ++VV +FS++ENKNV P + +
Sbjct: 206 LSKINIREELMKFHSKWYSANIMSLAVFGKESLDELESMVVSMFSDIENKNVTSPCWKDL 265
Query: 292 PFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELK 351
PF+EEHL +VP+KD R+L +TF DL++YYK+ P HY+ HLIGHEG GS+LSELK
Sbjct: 266 PFKEEHLATKTTVVPVKDTRSLTITFQTEDLERYYKAGPEHYVSHLIGHEGAGSILSELK 325
Query: 352 SKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVF 411
+KGW N LVGG RGF FF + VDLT++G HV+DI+ +FQYI L+ EGPQ+W+F
Sbjct: 326 AKGWCNNLVGGYSTIGRGFGFFEVMVDLTQDGFDHVDDIVKIIFQYIHMLKTEGPQKWIF 385
Query: 412 QECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKL 471
+E DL + FRFKDKE P S + + YPLEEVL A YL+ E+RP+LIE + +K
Sbjct: 386 EEYCDLCEMQFRFKDKENPLSLVSNVVHSMQSYPLEEVLAAPYLISEWRPELIEELWNKF 445
Query: 472 RPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFI 531
P+N R+ +V + E T++ EEWYGT+Y EAIP V+++W DLN LP +N FI
Sbjct: 446 FPQNARITVVGQKCESVTNQEEEWYGTKYSSEAIPKNVLEEWAKPDLNANLHLPERNPFI 505
Query: 532 PTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCN 591
PT+FE++P++ + P +I +T M ++WFKQD +F PK +N +F SP Y DPL+CN
Sbjct: 506 PTDFELVPVDADIQSTPVIIHNTPMIRVWFKQDVEFLKPKTLMNLDFCSPIVYSDPLNCN 565
Query: 592 MAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMAT 651
+ +L+++L KD LNEY YAA+LAGL + NT YG+ +S+ GY+ KQ ILL+K+++ +
Sbjct: 566 LTHLFVQLFKDHLNEYLYAADLAGLRLVVSNTTYGISVSIGGYSHKQHILLEKVLDNLYN 625
Query: 652 FEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPR 711
F+IDEKRF+I+KE Y+R+L N+ AEQP+QHA+YYL LL+TE AW+K EL +A D +++ R
Sbjct: 626 FKIDEKRFDILKEQYVRNLKNYNAEQPYQHAVYYLALLLTEQAWSKQELIDAADLLSVDR 685
Query: 712 LKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIE-HAHTKPLLPSQLVRYREVQ 770
L++FI +LLSR+H+E ++GN+ K+ AL I VED L A PLL QL+ RE +
Sbjct: 686 LRSFIDELLSRMHVECFIYGNVNKENALEISGKVEDKLKNTDASVVPLLARQLMLKREYK 745
Query: 771 LPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLG 830
L + +++ N+ H + E+Y Q MQ N+F++L QI+SEPC+N LRTKEQLG
Sbjct: 746 LNNGENCLFETNNDYHKSSCAELYLQCGMQDDQSNVFVDLVTQILSEPCYNQLRTKEQLG 805
Query: 831 YIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALA 890
YIVF G R++NG+QG+R I+QS K P Y+E R+E FL M + +E+M+EE F++H +ALA
Sbjct: 806 YIVFCGSRKSNGVQGIRVIVQSAKHPAYVEERIEHFLNGMIEQLENMSEEEFKRHKEALA 865
Query: 891 IRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPR 950
++L+KPK+LS + K+ EI QQY+F+R EVA+L+TLTK+ II++YK+ + + AP
Sbjct: 866 AQKLEKPKRLSTQFGKFLTEISLQQYHFNRAQVEVAFLQTLTKQQIIEYYKDYIILGAPS 925
Query: 951 RHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKP 1010
R +S+HV++ P + + ++ + ++ FK L+P+V+P
Sbjct: 926 RRSLSIHVVSTAEGGAGHRDAPPEATERSTNETADAKDFVKVCDLASFKSTRALYPMVQP 985
Query: 1011 HIN 1013
+I+
Sbjct: 986 YID 988
>ref|XP_001661876.1| metalloprotease [Aedes aegypti]
gb|EAT36161.1| metalloprotease [Aedes aegypti]
Length = 1003
Score = 997 bits (2578), Expect = 0.0, Method: Composition-based stats.
Identities = 487/966 (50%), Positives = 676/966 (69%), Gaps = 7/966 (0%)
Query: 52 NHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCE 111
++ITKS +D R YRGL+L NG+KVLLISDPTTDKS+AAL V +G LSDP I GL+HFCE
Sbjct: 31 DNITKSQQDSRNYRGLQLENGLKVLLISDPTTDKSAAALSVAVGHLSDPDEIPGLAHFCE 90
Query: 112 HMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLC 171
HMLFLGTKKY EN+Y FLSE+ GSSNA T + T YYFDV E L ALDRF+QFF+
Sbjct: 91 HMLFLGTKKYVNENDYMSFLSENGGSSNAATYADTTKYYFDVVPEKLPEALDRFSQFFIA 150
Query: 172 PLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPN 231
PLF ES +RE+NAV SEHEKN+ D WR+ Q+ K+ +PKHP++KFGTG+K TL P
Sbjct: 151 PLFTESATEREINAVHSEHEKNLSMDVWRIRQVNKSLCDPKHPYNKFGTGSKKTLLEDPK 210
Query: 232 QEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEH 291
I++R+EL+KFH+ +YS+N+M++ V G+ESLDDL ++VV +FSE+ENKNV PE+ +
Sbjct: 211 TTNINIREELMKFHAKWYSANIMSLAVFGKESLDDLESMVVGMFSEIENKNVTSPEWKDL 270
Query: 292 PFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELK 351
P++ + L K+VP+KD R+L +TF DL+++Y++ P HY HLIGHEG GS+LSELK
Sbjct: 271 PYKNDQLATKTKVVPVKDSRSLTITFQTEDLEQHYRAGPEHYASHLIGHEGAGSILSELK 330
Query: 352 SKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVF 411
+KGW N LVGG RGF FF + VDLT++G HV+DI+ +FQYI L+ EGPQ+W+F
Sbjct: 331 AKGWCNNLVGGYNTIGRGFGFFEVMVDLTQDGFEHVDDIVKIIFQYINMLKKEGPQKWIF 390
Query: 412 QECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKL 471
+E DL + FRFKDKE P S + + YPLEEVL A YL+ E+RPDLIE + +K
Sbjct: 391 EEYCDLCEMQFRFKDKENPLTLVSSVVHSMQSYPLEEVLAAPYLISEWRPDLIEDLWNKF 450
Query: 472 RPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFI 531
P+N R+ +V + E K EEWYGT+Y E I +V++ W +DLNG LP +N FI
Sbjct: 451 YPQNARITVVGQKCEAKATCEEEWYGTKYSTEKIDAKVLEDWAKSDLNGNLHLPERNPFI 510
Query: 532 PTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCN 591
PTNF++L ++ + P +I +T M ++WFKQD +F PK +N +F SP Y DPL+CN
Sbjct: 511 PTNFDLLAVDADIESIPVIIHNTPMMRVWFKQDVEFLKPKTLMNLDFCSPIVYSDPLNCN 570
Query: 592 MAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMAT 651
+ +L+++L KD LNEY YAA LAGL + NT YG+ +S+ GY+ KQ ILL+K+++ M
Sbjct: 571 LTHLFVQLFKDHLNEYLYAAGLAGLRLGVANTTYGVSVSIGGYSHKQHILLEKVLDDMFN 630
Query: 652 FEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPR 711
F+IDEKRFEI+KE Y+R+L N++AEQP+QHA+YYL LL+TE AW+K EL +A + VT+ R
Sbjct: 631 FKIDEKRFEILKEQYIRNLKNYQAEQPYQHAVYYLALLLTEQAWSKQELIDATELVTVDR 690
Query: 712 LKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIE-HAHTKPLLPSQLVRYREVQ 770
L+ FI +LLSR+H+E ++GN+ K+ AL + VED L + A+ PLL QL+ RE +
Sbjct: 691 LRTFIDELLSRMHVECFIYGNVNKEKALEMSSKVEDKLKKTDANVVPLLARQLMLKREYK 750
Query: 771 LPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLG 830
L + +++ NE H + E+Y Q MQ+ N++++L QI+SEPC+N LRTKEQLG
Sbjct: 751 LNNGENCLFEMTNEFHKSSCAELYLQCGMQNDQANVYVDLVTQILSEPCYNQLRTKEQLG 810
Query: 831 YIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALA 890
YIVF G R++NG+QG+R I+QS P ++E R+E FL M +E+MTEE F++H +ALA
Sbjct: 811 YIVFCGSRKSNGVQGIRVIVQSANHPAFVEERIEHFLNGMVDYLENMTEEEFKRHKEALA 870
Query: 891 IRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPR 950
+L+KPK+LS++ K+ EI QQY+F+R EVA+L+TLTK+ I+ +YKE + DA
Sbjct: 871 AMKLEKPKRLSSQFTKFLNEIALQQYHFNRAQVEVAFLQTLTKQQIVDYYKEYIVKDASL 930
Query: 951 RHKVSVHVLAREMDSCPVVGEFPCQNDI-NLSQAPALPQPEVIQ--NMTEFKRGLPLFPL 1007
R +S+HV++ G D+ S A Q + ++ ++ FK L+P+
Sbjct: 931 RRSLSIHVVSTAEGG---AGHKDASADVAKQSTDDASTQKDFVKVGDLAGFKSTRALYPM 987
Query: 1008 VKPHIN 1013
V+P+I+
Sbjct: 988 VQPYID 993
>emb|CAF89725.1| unnamed protein product [Tetraodon nigroviridis]
Length = 592
Score = 977 bits (2525), Expect = 0.0, Method: Composition-based stats.
Identities = 477/629 (75%), Positives = 521/629 (82%), Gaps = 77/629 (12%)
Query: 42 MNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPP 101
M +PA+K + + I +SPEDKR YRGLE +NG+KV+L+SDPTTDKSSAALDVHIGSLSDP
Sbjct: 1 MTDPAVKMVVDDIIRSPEDKRVYRGLEFSNGLKVMLVSDPTTDKSSAALDVHIGSLSDPD 60
Query: 102 NIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGA 161
NI+GL+HFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFD+SHEHL+GA
Sbjct: 61 NISGLAHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDISHEHLQGA 120
Query: 162 LDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTG 221
LDRFAQFFLCPLFDESCKDREVNAVDSEHEKN+MNDAWRLFQLEKATGNP HPFSKFGTG
Sbjct: 121 LDRFAQFFLCPLFDESCKDREVNAVDSEHEKNLMNDAWRLFQLEKATGNPNHPFSKFGTG 180
Query: 222 NKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENK 281
NK TLETRP+Q+GIDVRQELL FHS YYSSNLM +CVLGRESLD+LT++VV+LF EVENK
Sbjct: 181 NKLTLETRPSQQGIDVRQELLHFHSTYYSSNLMGLCVLGRESLDELTSMVVQLFGEVENK 240
Query: 282 NVPLPEFPEHPFQEEHLK-------------QLYKIVPIKDIRNLYVTFPIPDLQKYYKS 328
NVP+PEFPEHPFQE+ LK Q YK+VP+KDIRNLYVTFPIPDLQ+YYKS
Sbjct: 241 NVPIPEFPEHPFQEDQLKVSPGGLQDLAVNPQFYKVVPVKDIRNLYVTFPIPDLQRYYKS 300
Query: 329 NPGHYLGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVE 388
NPGHYLGHLIGHEGPGSLLSELKSK +HVE
Sbjct: 301 NPGHYLGHLIGHEGPGSLLSELKSK-------------------------------VHVE 329
Query: 389 DIILHMFQYIQKLRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILH------ 442
DII HMFQYIQKLR EGPQEWVFQECKDLN VAFRFKDKERPRGYTSK+AG+LH
Sbjct: 330 DIIFHMFQYIQKLRTEGPQEWVFQECKDLNQVAFRFKDKERPRGYTSKVAGLLHVGPVSS 389
Query: 443 ---------------------YYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAIV 481
YYPL EVL AEYLLE+FRPDLI+MVLDKLRPE VRVA+V
Sbjct: 390 GRVWVWLAALPPDNARLCLLQYYPLREVLAAEYLLEDFRPDLIQMVLDKLRPEYVRVAVV 449
Query: 482 SKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPLE 541
SKSFEG+TD+TEEWYGTQY+QE I + ++KW NADLNGKFKLPT+NEFIPTNFEI PLE
Sbjct: 450 SKSFEGQTDKTEEWYGTQYRQEDISEATVQKWANADLNGKFKLPTRNEFIPTNFEIYPLE 509
Query: 542 KEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELLK 601
KE+ DTAMSK+WFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELLK
Sbjct: 510 KESP------SDTAMSKVWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELLK 563
Query: 602 DSLNEYAYAAELAGLSYDLQNTIYGMYLS 630
DSLNEYAYAAELAGL+YDLQNT+YGM+ S
Sbjct: 564 DSLNEYAYAAELAGLNYDLQNTVYGMHAS 592
>ref|XP_001194830.1| PREDICTED: similar to Insulin-degrading enzyme [Strongylocentrotus
purpuratus]
Length = 745
Score = 929 bits (2400), Expect = 0.0, Method: Composition-based stats.
Identities = 424/662 (64%), Positives = 538/662 (81%)
Query: 44 NPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNI 103
NPAI + +ITKS EDKR YRGL+L NG+K++LISDPTT+KS+AA+DV+IGSLSDP I
Sbjct: 6 NPAIAKQYENITKSAEDKRLYRGLQLNNGMKIILISDPTTEKSAAAMDVNIGSLSDPWEI 65
Query: 104 AGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALD 163
GL+HF EHMLFLGT+KYP EN YSQFL+EH G +NA+TSGEHTN+YFDVS+EH+EGALD
Sbjct: 66 PGLAHFLEHMLFLGTEKYPSENAYSQFLNEHGGFANAYTSGEHTNFYFDVSYEHIEGALD 125
Query: 164 RFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNK 223
RFAQFF CPLF++ +DREVNAVDSE++KN+ D+WR+ QL+K T NP HPFSKF TGNK
Sbjct: 126 RFAQFFHCPLFNQDAQDREVNAVDSENDKNLKADSWRIHQLDKGTVNPSHPFSKFNTGNK 185
Query: 224 YTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNV 283
TL T P +GIDVR+ELLKFHS +YSSN+M + VLGRESLD L+ +V++LF+ VENKNV
Sbjct: 186 ETLATIPLDKGIDVRKELLKFHSDFYSSNIMGLAVLGRESLDQLSEIVLQLFANVENKNV 245
Query: 284 PLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGP 343
+PE+ EHP+ + LK +++VP+KD+R L V+FPIPDLQ++YKS P HYLGHL+GHEGP
Sbjct: 246 MIPEWLEHPYGTDQLKVKFEVVPVKDLRQLNVSFPIPDLQEHYKSKPAHYLGHLVGHEGP 305
Query: 344 GSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRA 403
GSLLSELK++GWVNTL GG+K+GA+GF FFIINVDL+EEGL HV+DII+HMFQY+ LR
Sbjct: 306 GSLLSELKARGWVNTLCGGEKDGAKGFAFFIINVDLSEEGLDHVDDIIMHMFQYLNMLRK 365
Query: 404 EGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDL 463
EGPQ WV EC+DL+ + FRFKDKERP GY +K+A +LH YP++EVL+A YL+ EF+PD+
Sbjct: 366 EGPQSWVHDECRDLDTMRFRFKDKERPSGYVTKMAHLLHDYPMDEVLSAPYLMPEFKPDV 425
Query: 464 IEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFK 523
I +L++L PENVRVA+VSKSFEGKT++ E+WYGT+Y I +IK W A LN KF
Sbjct: 426 ITQILERLTPENVRVAVVSKSFEGKTEQVEKWYGTEYSIRNIEPSMIKTWSEAGLNEKFS 485
Query: 524 LPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFA 583
LP +NEFIPTNFE+ P EKE P ++++T +SKLWFKQDD F LPKAC+ E SP A
Sbjct: 486 LPLRNEFIPTNFEVAPREKEGAATPTMVRETPVSKLWFKQDDTFLLPKACMLLEISSPLA 545
Query: 584 YVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLK 643
Y+DPLHCN+ ++ LL+D+LNEYAYAAE+AG+SY + +TIYG+ + V GY+DK +LL+
Sbjct: 546 YIDPLHCNLTSIFCTLLRDALNEYAYAAEIAGVSYSIDSTIYGLEVGVGGYSDKMALLLQ 605
Query: 644 KIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEA 703
+I EKM F IDE RF++IKE Y R L+NF AEQPH+HA+YY +L+ E AWTK +L +
Sbjct: 606 RIFEKMTNFVIDENRFDVIKETYSRMLSNFHAEQPHRHAVYYTSVLVAEQAWTKLDLAQC 665
Query: 704 LD 705
+D
Sbjct: 666 MD 667
>gb|AAO74689.1| RE17458p [Drosophila melanogaster]
Length = 1031
Score = 925 bits (2390), Expect = 0.0, Method: Composition-based stats.
Identities = 451/966 (46%), Positives = 650/966 (67%), Gaps = 8/966 (0%)
Query: 52 NHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCE 111
N+I KS +D R+YRGL+L NG+KVLLISDP TD S+AAL V +G +SDP N+ GL+HFCE
Sbjct: 66 NNIEKSLQDTRDYRGLQLENGLKVLLISDPNTDVSAAALSVQVGHMSDPTNLPGLAHFCE 125
Query: 112 HMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLC 171
HMLFLGT+KYP EN Y+ +LS+ GSSNA T T Y+F V+ + L+GALDRFAQFF+
Sbjct: 126 HMLFLGTEKYPHENGYTTYLSQSGGSSNAATYPLMTKYHFHVAPDKLDGALDRFAQFFIA 185
Query: 172 PLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPN 231
PLF S +RE+NAV+SEHEKN+ +D WR+ Q+++ P H +SKFG+GNK TL P
Sbjct: 186 PLFTPSATEREINAVNSEHEKNLPSDLWRIKQVDRHLAKPDHAYSKFGSGNKTTLSEIPK 245
Query: 232 QEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEH 291
+ IDVR ELLKFH +YS+N+M + V+G+ESLD+L +V++ FSE+ENKNV +P +P H
Sbjct: 246 SKNIDVRDELLKFHKQWYSANIMCLAVIGKESLDELEGMVLEKFSEIENKNVKVPGWPRH 305
Query: 292 PFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELK 351
P+ EE Q KIVPIKDIR+L ++F DL ++YKS P +YL HLIGHEG GS+LSEL+
Sbjct: 306 PYAEERYGQKVKIVPIKDIRSLTISFTTDDLTQFYKSGPDNYLTHLIGHEGKGSILSELR 365
Query: 352 SKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVF 411
GW N L+ G + GF FF I VDLT+EGL HV+DI+ +FQY++ LR EGP++W+F
Sbjct: 366 RLGWCNDLMAGHQNTQNGFGFFDIVVDLTQEGLEHVDDIVKIVFQYLEMLRKEGPKKWIF 425
Query: 412 QECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKL 471
EC LN + FRFK+KE+P + + +PLEEVL A YL E+RPDLI+ +LD+L
Sbjct: 426 DECVKLNEMRFRFKEKEQPENLVTHAVSSMQIFPLEEVLIAPYLSNEWRPDLIKGLLDEL 485
Query: 472 RPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFI 531
P R+ IVS+SFE D E +Y T+Y + + ++ W+N +LN KL N FI
Sbjct: 486 VPSKSRIVIVSQSFEPDCDLAEPYYKTKYGITRVAKDTVQSWENCELNENLKLALPNSFI 545
Query: 532 PTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCN 591
PTNF+I + +A +P +I DT + ++W KQD++F PKAC+ F+ +P AY+DPL+CN
Sbjct: 546 PTNFDISDVPADAPKHPTIILDTPILRVWHKQDNQFNKPKACMTFDMSNPIAYLDPLNCN 605
Query: 592 MAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMAT 651
+ ++ + LLKD LNEY Y AELA L + G+ +++G++DKQ +LL+K+++ +
Sbjct: 606 LNHMMVMLLKDQLNEYLYDAELASLKLSVMGKSCGIDFTIRGFSDKQVVLLEKLLDHLFD 665
Query: 652 FEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPR 711
F IDEKRF+I+KE Y+RSL NF+AEQP+QH++YYL LL+TE AW EL +A++ VT R
Sbjct: 666 FSIDEKRFDILKEEYVRSLKNFKAEQPYQHSIYYLALLLTENAWANMELLDAMELVTYDR 725
Query: 712 LKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTL-IEHAHTKPLLPSQLVRYREVQ 770
+ F + RLH E + GN+TKQ A I V L +A P+L Q+++ RE +
Sbjct: 726 VLNFAKEFFQRLHTECFIFGNVTKQQATDIAGRVNTRLEATNASKLPILARQMLKKREYK 785
Query: 771 LPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLG 830
L +++++ NE H + ++Y Q Q+ N+ + L Q++SEPC++ LRTKEQLG
Sbjct: 786 LLAGDSYLFEKENEFHKSSCAQLYLQCGAQTDHTNIMVNLVSQVLSEPCYDCLRTKEQLG 845
Query: 831 YIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALA 890
YIVFSG R+ NG G+R I+QS K P Y+E R+E FL T + IEDM + F++H +ALA
Sbjct: 846 YIVFSGVRKVNGANGIRIIVQSAKHPSYVEDRIENFLQTYLQVIEDMPLDEFERHKEALA 905
Query: 891 IRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPR 950
+++L+KPK + + ++++GEI Q Y+F+R+ EVA L+ ++K D + ++K+ +A D
Sbjct: 906 VKKLEKPKTIFQQFSQFYGEIAMQTYHFEREEAEVAILRKISKADFVDYFKKFIAKDGEE 965
Query: 951 RHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKP 1010
R +SVH+++++ D P + + + + I ++ FK L+P+ P
Sbjct: 966 RRVLSVHIVSQQTDENATSEAEPV-------EITNMERHKPISDIVTFKSCKELYPIALP 1018
Query: 1011 HINFMA 1016
++ A
Sbjct: 1019 FLDIKA 1024
>ref|NP_524182.2| Insulin degrading metalloproteinase CG5517-PA [Drosophila
melanogaster]
gb|AAF51584.2| CG5517-PA [Drosophila melanogaster]
Length = 1031
Score = 924 bits (2388), Expect = 0.0, Method: Composition-based stats.
Identities = 451/966 (46%), Positives = 649/966 (67%), Gaps = 8/966 (0%)
Query: 52 NHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCE 111
N+I KS +D R+YRGL+L NG+KVLLISDP TD S+AAL V +G +SDP N+ GL+HFCE
Sbjct: 66 NNIEKSLQDTRDYRGLQLENGLKVLLISDPNTDVSAAALSVQVGHMSDPTNLPGLAHFCE 125
Query: 112 HMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLC 171
HMLFLGT+KYP EN Y+ +LS+ GSSNA T T Y+F V+ + L+GALDRFAQFF+
Sbjct: 126 HMLFLGTEKYPHENGYTTYLSQSGGSSNAATYPLMTKYHFHVAPDKLDGALDRFAQFFIA 185
Query: 172 PLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPN 231
PLF S +RE+NAV+SEHEKN+ +D WR+ Q+ + P H +SKFG+GNK TL P
Sbjct: 186 PLFTPSATEREINAVNSEHEKNLPSDLWRIKQVNRHLAKPDHAYSKFGSGNKTTLSEIPK 245
Query: 232 QEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEH 291
+ IDVR ELLKFH +YS+N+M + V+G+ESLD+L +V++ FSE+ENKNV +P +P H
Sbjct: 246 SKNIDVRDELLKFHKQWYSANIMCLAVIGKESLDELEGMVLEKFSEIENKNVKVPGWPRH 305
Query: 292 PFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELK 351
P+ EE Q KIVPIKDIR+L ++F DL ++YKS P +YL HLIGHEG GS+LSEL+
Sbjct: 306 PYAEERYGQKVKIVPIKDIRSLTISFTTDDLTQFYKSGPDNYLTHLIGHEGKGSILSELR 365
Query: 352 SKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVF 411
GW N L+ G + GF FF I VDLT+EGL HV+DI+ +FQY++ LR EGP++W+F
Sbjct: 366 RLGWCNDLMAGHQNTQNGFGFFDIVVDLTQEGLEHVDDIVKIVFQYLEMLRKEGPKKWIF 425
Query: 412 QECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKL 471
EC LN + FRFK+KE+P + + +PLEEVL A YL E+RPDLI+ +LD+L
Sbjct: 426 DECVKLNEMRFRFKEKEQPENLVTHAVSSMQIFPLEEVLIAPYLSNEWRPDLIKGLLDEL 485
Query: 472 RPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFI 531
P R+ IVS+SFE D E +Y T+Y + + ++ W+N +LN KL N FI
Sbjct: 486 VPSKSRIVIVSQSFEPDCDLAEPYYKTKYGITRVAKDTVQSWENCELNENLKLALPNSFI 545
Query: 532 PTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCN 591
PTNF+I + +A +P +I DT + ++W KQD++F PKAC+ F+ +P AY+DPL+CN
Sbjct: 546 PTNFDISDVPADAPKHPTIILDTPILRVWHKQDNQFNKPKACMTFDMSNPIAYLDPLNCN 605
Query: 592 MAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMAT 651
+ ++ + LLKD LNEY Y AELA L + G+ +++G++DKQ +LL+K+++ +
Sbjct: 606 LNHMMVMLLKDQLNEYLYDAELASLKLSVMGKSCGIDFTIRGFSDKQVVLLEKLLDHLFD 665
Query: 652 FEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPR 711
F IDEKRF+I+KE Y+RSL NF+AEQP+QH++YYL LL+TE AW EL +A++ VT R
Sbjct: 666 FSIDEKRFDILKEEYVRSLKNFKAEQPYQHSIYYLALLLTENAWANMELLDAMELVTYDR 725
Query: 712 LKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTL-IEHAHTKPLLPSQLVRYREVQ 770
+ F + RLH E + GN+TKQ A I V L +A P+L Q+++ RE +
Sbjct: 726 VLNFAKEFFQRLHTECFIFGNVTKQQATDIAGRVNTRLEATNASKLPILARQMLKKREYK 785
Query: 771 LPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLG 830
L +++++ NE H + ++Y Q Q+ N+ + L Q++SEPC++ LRTKEQLG
Sbjct: 786 LLAGDSYLFEKENEFHKSSCAQLYLQCGAQTDHTNIMVNLVSQVLSEPCYDCLRTKEQLG 845
Query: 831 YIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALA 890
YIVFSG R+ NG G+R I+QS K P Y+E R+E FL T + IEDM + F++H +ALA
Sbjct: 846 YIVFSGVRKVNGANGIRIIVQSAKHPSYVEDRIENFLQTYLQVIEDMPLDEFERHKEALA 905
Query: 891 IRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPR 950
+++L+KPK + + ++++GEI Q Y+F+R+ EVA L+ ++K D + ++K+ +A D
Sbjct: 906 VKKLEKPKTIFQQFSQFYGEIAMQTYHFEREEAEVAILRKISKADFVDYFKKFIAKDGEE 965
Query: 951 RHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKP 1010
R +SVH+++++ D P + + + + I ++ FK L+P+ P
Sbjct: 966 RRVLSVHIVSQQTDENATSEAEPV-------EITNMERHKPISDIVTFKSCKELYPIALP 1018
Query: 1011 HINFMA 1016
++ A
Sbjct: 1019 FLDIKA 1024
>ref|XP_795975.2| PREDICTED: similar to Insulin-degrading enzyme, partial
[Strongylocentrotus purpuratus]
Length = 667
Score = 922 bits (2383), Expect = 0.0, Method: Composition-based stats.
Identities = 424/662 (64%), Positives = 538/662 (81%)
Query: 44 NPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNI 103
NPAI + +ITKS EDKR YRGL+L NG+K++LISDPTT+KS+AA+DV+IGSLSDP I
Sbjct: 6 NPAIAKQYENITKSAEDKRLYRGLQLNNGMKIILISDPTTEKSAAAMDVNIGSLSDPWEI 65
Query: 104 AGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALD 163
GL+HF EHMLFLGT+KYP EN YSQFL+EH G +NA+TSGEHTN+YFDVS+EH+EGALD
Sbjct: 66 PGLAHFLEHMLFLGTEKYPSENAYSQFLNEHGGFANAYTSGEHTNFYFDVSYEHIEGALD 125
Query: 164 RFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNK 223
RFAQFF CPLF++ +DREVNAVDSE++KN+ D+WR+ QL+K T NP HPFSKF TGNK
Sbjct: 126 RFAQFFHCPLFNQDAQDREVNAVDSENDKNLKADSWRIHQLDKGTVNPSHPFSKFNTGNK 185
Query: 224 YTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNV 283
TL T P +GIDVR+ELLKFHS +YSSN+M + VLGRESLD L+ +V++LF+ VENKNV
Sbjct: 186 ETLATIPLDKGIDVRKELLKFHSDFYSSNIMGLAVLGRESLDQLSEIVLQLFANVENKNV 245
Query: 284 PLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGP 343
+PE+ EHP+ + LK +++VP+KD+R L V+FPIPDLQ++YKS P HYLGHL+GHEGP
Sbjct: 246 MIPEWLEHPYGTDQLKVKFEVVPVKDLRQLNVSFPIPDLQEHYKSKPAHYLGHLVGHEGP 305
Query: 344 GSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRA 403
GSLLSELK++GWVNTL GG+K+GA+GF FFIINVDL+EEGL HV+DII+HMFQY+ LR
Sbjct: 306 GSLLSELKARGWVNTLCGGEKDGAKGFAFFIINVDLSEEGLDHVDDIIMHMFQYLNMLRK 365
Query: 404 EGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDL 463
EGPQ WV EC+DL+ + FRFKDKERP GY +K+A +LH YP++EVL+A YL+ EF+PD+
Sbjct: 366 EGPQSWVHDECRDLDTMRFRFKDKERPSGYVTKMAHLLHDYPMDEVLSAPYLMPEFKPDV 425
Query: 464 IEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFK 523
I +L++L PENVRVA+VSKSFEGKT++ E+WYGT+Y I +IK W A LN KF
Sbjct: 426 ITQILERLTPENVRVAVVSKSFEGKTEQVEKWYGTEYSIRNIEPSMIKTWSEAGLNEKFS 485
Query: 524 LPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFA 583
LP +NEFIPTNFE+ P EKE P ++++T +SKLWFKQDD F LPKAC+ E SP A
Sbjct: 486 LPLRNEFIPTNFEVAPREKEGAATPTMVRETPVSKLWFKQDDTFLLPKACMLLEISSPLA 545
Query: 584 YVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLK 643
Y+DPLHCN+ ++ LL+D+LNEYAYAAE+AG+SY + +TIYG+ + V GY+DK +LL+
Sbjct: 546 YIDPLHCNLTSIFCTLLRDALNEYAYAAEIAGVSYSIDSTIYGLEVGVGGYSDKMALLLQ 605
Query: 644 KIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEA 703
+I EKM F IDE RF++IKE Y R L+NF AEQPH+HA+YY +L+ E AWTK +L +
Sbjct: 606 RIFEKMTNFVIDENRFDVIKETYSRMLSNFHAEQPHRHAVYYTSVLVAEQAWTKLDLAQC 665
Query: 704 LD 705
+D
Sbjct: 666 MD 667
>sp|P22817|IDE_DROME Insulin-degrading enzyme (Insulysin) (Insulinase) (Insulin protease)
Length = 990
Score = 920 bits (2377), Expect = 0.0, Method: Composition-based stats.
Identities = 451/966 (46%), Positives = 649/966 (67%), Gaps = 8/966 (0%)
Query: 52 NHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCE 111
N+I KS +D R+YRGL+L NG+KVLLISDP TD S+AAL V +G +SDP N+ GL+HFCE
Sbjct: 25 NNIEKSLQDTRDYRGLQLENGLKVLLISDPNTDVSAAALSVQVGHMSDPTNLPGLAHFCE 84
Query: 112 HMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLC 171
HMLFLGT+KYP EN Y+ +LS+ GSSNA T T Y+F V+ + L+GALDRFAQFF+
Sbjct: 85 HMLFLGTEKYPHENGYTTYLSQSGGSSNAATYPLMTKYHFHVAPDKLDGALDRFAQFFIA 144
Query: 172 PLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPN 231
PLF S +RE+NAV+SEHEKN+ +D WR+ Q+ + P H +SKFG+GNK TL P
Sbjct: 145 PLFTPSATEREINAVNSEHEKNLPSDLWRIKQVNRHLAKPDHAYSKFGSGNKTTLSEIPK 204
Query: 232 QEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEH 291
+ IDVR ELLKFH +YS+N+M + V+G+ESLD+L +V++ FSE+ENKNV +P +P H
Sbjct: 205 SKNIDVRDELLKFHKQWYSANIMCLAVIGKESLDELEGMVLEKFSEIENKNVKVPGWPRH 264
Query: 292 PFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELK 351
P+ EE Q KIVPIKDIR+L ++F DL ++YKS P +YL HLIGHEG GS+LSEL+
Sbjct: 265 PYAEERYGQKVKIVPIKDIRSLTISFTTDDLTQFYKSGPDNYLTHLIGHEGKGSILSELR 324
Query: 352 SKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVF 411
GW N L+ G + GF FF I VDLT+EGL HV+DI+ +FQY++ LR EGP++W+F
Sbjct: 325 RLGWCNDLMAGHQNTQNGFGFFDIVVDLTQEGLEHVDDIVKIVFQYLEMLRKEGPKKWIF 384
Query: 412 QECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKL 471
EC LN + FRFK+KE+P + + +PLEEVL A YL E+RPDLI+ +LD+L
Sbjct: 385 DECVKLNEMRFRFKEKEQPENLVTHAVSSMQIFPLEEVLIAPYLSNEWRPDLIKGLLDEL 444
Query: 472 RPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFI 531
P R+ IVS+SFE D E +Y T+Y + + ++ W+N +LN KL N FI
Sbjct: 445 VPSKSRIVIVSQSFEPDCDLAEPYYKTKYGITRVAKDTVQSWENCELNENLKLALPNSFI 504
Query: 532 PTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCN 591
PTNF+I + +A +P +I DT + ++W KQD++F PKAC+ F+ +P AY+DPL+CN
Sbjct: 505 PTNFDISDVPADAPKHPTIILDTPILRVWHKQDNQFNKPKACMTFDMSNPIAYLDPLNCN 564
Query: 592 MAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMAT 651
+ ++ + LLKD LNEY Y AELA L + G+ +++G++DKQ +LL+K+++ +
Sbjct: 565 LNHMMVMLLKDQLNEYLYDAELASLKLSVMGKSCGIDFTIRGFSDKQVVLLEKLLDHLFD 624
Query: 652 FEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPR 711
F IDEKRF+I+KE Y+RSL NF+AEQP+QH++YYL LL+TE AW EL +A++ VT R
Sbjct: 625 FSIDEKRFDILKEEYVRSLKNFKAEQPYQHSIYYLALLLTENAWANMELLDAMELVTYDR 684
Query: 712 LKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTL-IEHAHTKPLLPSQLVRYREVQ 770
+ F + RLH E + GN+TKQ A I V L +A P+L Q+++ RE +
Sbjct: 685 VLNFAKEFFQRLHTECFIFGNVTKQQATDIAGRVNTRLEATNASKLPILARQMLKKREYK 744
Query: 771 LPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLG 830
L +++++ NE H + ++Y Q Q+ N+ + L Q++SEPC++ LRTKEQLG
Sbjct: 745 LLAGDSYLFEKENEFHKSSCAQLYLQCGAQTDHTNIMVNLVSQVLSEPCYDCLRTKEQLG 804
Query: 831 YIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALA 890
YIVFSG R+ NG G+R I+QS K P Y+E R+E FL T + IEDM + F++H +ALA
Sbjct: 805 YIVFSGVRKVNGANGIRIIVQSAKHPSYVEDRIENFLQTYLQVIEDMPLDEFERHKEALA 864
Query: 891 IRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPR 950
+++L+KPK + + ++++GEI Q Y+F+R+ EVA L+ ++K D + ++K+ +A D
Sbjct: 865 VKKLEKPKTIFQQFSQFYGEIAMQTYHFEREEAEVAILRKISKADFVDYFKKFIAKDGEE 924
Query: 951 RHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKP 1010
R +SVH+++++ D P + + + + I ++ FK L+P+ P
Sbjct: 925 RRVLSVHIVSQQTDENATSEAEPV-------EITNMERHKPISDIVTFKSCKELYPIALP 977
Query: 1011 HINFMA 1016
++ A
Sbjct: 978 FLDIKA 983
>ref|XP_311589.4| AGAP010351-PA [Anopheles gambiae str. PEST]
gb|EAA07246.4| AGAP010351-PA [Anopheles gambiae str. PEST]
Length = 1030
Score = 914 bits (2362), Expect = 0.0, Method: Composition-based stats.
Identities = 450/976 (46%), Positives = 646/976 (66%), Gaps = 16/976 (1%)
Query: 44 NPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNI 103
N +RI N ITKS +D R+YRGL L+NG+KV+LISDPTTD+S+AAL V +G LSDP I
Sbjct: 59 NMPFERI-NTITKSVQDNRDYRGLRLSNGMKVILISDPTTDRSAAALSVAVGHLSDPLQI 117
Query: 104 AGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALD 163
GL+H CEHMLFLGT+KYPKE+EY+ FL H GSSNA T + T YYFDV LE ALD
Sbjct: 118 PGLAHLCEHMLFLGTEKYPKEDEYTAFLKVHGGSSNAATCSDMTKYYFDVIPSKLEDALD 177
Query: 164 RFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNK 223
RF+QFF+ PLF+E +RE+NAV+SEHEKN+ D WR+ Q+ KA HP+++FGTGNK
Sbjct: 178 RFSQFFIAPLFNEEVTEREINAVNSEHEKNLSQDVWRVKQVNKALCKSTHPYNQFGTGNK 237
Query: 224 YTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNV 283
TL P I+VR EL+ FH+ +YSSN+M++ V G+ESLDDL LV+K FS++ENK V
Sbjct: 238 QTLSESPKLNSINVRNELMTFHNKWYSSNIMSLAVFGQESLDDLEALVIKFFSQIENKQV 297
Query: 284 PLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGP 343
P +P+ P+ ++ L I+P+KD R+L ++F + DL++YYK+ P HY+ HLIGHEG
Sbjct: 298 VAPRWPDMPYGDDQLNTKTYIIPVKDTRSLTISFQMEDLEQYYKAGPEHYVSHLIGHEGK 357
Query: 344 GSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRA 403
GS+LSELK++GW N L+ G RGF F + VDLTE+G H++D + +FQYI LR
Sbjct: 358 GSILSELKARGWCNKLISGYCSLGRGFGSFDVMVDLTEDGFNHIDDTVKLIFQYINMLRV 417
Query: 404 EGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDL 463
+ PQ+W+F+E +L + FRFKDKE P + + +H +PLE+VL A L+ E+RPDL
Sbjct: 418 KKPQKWIFEEYCNLCEMLFRFKDKEGPTTLVTNVVSSMHLFPLEDVLVAHCLITEWRPDL 477
Query: 464 IEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFK 523
+E ++ KL P+ R+ IV + E + E WYGT+Y I V++ W DLN
Sbjct: 478 VEDLISKLTPDKARLIIVGQKCESLANAEERWYGTKYGVYKIEPSVLEYWSTPDLNDNLS 537
Query: 524 LPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFA 583
LP N FIPT+FE+LP++ +P +I+DT + + WFKQD +F PKA ++F+F SP
Sbjct: 538 LPEPNPFIPTDFELLPIDSGIENFPIVIQDTPIIRTWFKQDVEFLKPKALMSFDFNSPIV 597
Query: 584 YVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLK 643
Y +PL+CN+ L+++LLKD LNE+ + A+LAGL + + NT G+ LS+ GY+ KQ ILL+
Sbjct: 598 YSNPLNCNLTRLFVQLLKDHLNEFLFEADLAGLGFGVSNTTSGISLSIGGYSHKQVILLE 657
Query: 644 KIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEA 703
K+++ M F+ID +RFEI+KE Y+R L N++ EQP+QHA+YYL LL+TE AWT+ EL ++
Sbjct: 658 KVLDNMFNFKIDRRRFEILKEQYIRGLKNYQTEQPYQHAIYYLALLLTEQAWTRQELLDS 717
Query: 704 LDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIE-HAHTKPLLPSQ 762
+++ RL+ F+ QLLS++H+E ++GN+ K+ AL + ++VED + A PLL Q
Sbjct: 718 TQLLSIERLQLFLEQLLSQMHVECFIYGNVNKEKALLMTKLVEDKMKSTDAKLVPLLARQ 777
Query: 763 LVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNT 822
L+ RE +L F+++ NE H + +E+Y Q Q + F+++ Q++SE C+
Sbjct: 778 LLPKREYKLGTGESFLFEATNEFHKSSCMELYLQCGQQE-PHSTFVDILSQLLSEGCYTQ 836
Query: 823 LRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAF 882
LRTKEQLGY+VF G R+ANGI GLR I+QS + P Y+E R+E FL +E+M E F
Sbjct: 837 LRTKEQLGYLVFCGSRKANGICGLRIIVQSPRHPSYVEERIENFLNNTLDYLENMAECEF 896
Query: 883 QKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKE 942
+H +AL L+KPK+L + Y EI +QY+F+R + E L+TLTK+ +I +YKE
Sbjct: 897 NRHKEALVALLLEKPKRLVTQFNIYLQEISLRQYHFNRAHVEAEKLRTLTKQQVIDYYKE 956
Query: 943 MLAVDAPRRHKVSVHVLARE---MDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFK 999
+ + +P R +SV V++ ++ PV F + + ++ FK
Sbjct: 957 HIILGSPSRSTLSVRVISTASGGAENSPVAENFRTTKKDFIR----------VTDLASFK 1006
Query: 1000 RGLPLFPLVKPHINFM 1015
L+PL +P++ M
Sbjct: 1007 SSRSLYPLAQPYMEIM 1022
>gb|AAA28439.1| insulin-degrading enzyme
Length = 990
Score = 911 bits (2354), Expect = 0.0, Method: Composition-based stats.
Identities = 448/966 (46%), Positives = 645/966 (66%), Gaps = 8/966 (0%)
Query: 52 NHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCE 111
N+I KS +D R+YRGL+L NG+KVLLISDP TD S+AAL V +G +SDP N+ GL+HFCE
Sbjct: 25 NNIEKSLQDTRDYRGLQLENGLKVLLISDPNTDVSAAALSVQVGHMSDPTNLPGLAHFCE 84
Query: 112 HMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLC 171
HMLFLGT+KYP EN Y+ +LS+ GSSNA T T Y+F V+ + L+GALDRFAQFF+
Sbjct: 85 HMLFLGTEKYPHENGYTTYLSQSGGSSNAATYPLMTKYHFHVAPDKLDGALDRFAQFFIA 144
Query: 172 PLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPN 231
PLF S +RE+NAV+SEHEKN+ +D WR+ Q+ + P H +SKFG+GNK TL P
Sbjct: 145 PLFTPSATEREINAVNSEHEKNLPSDLWRIKQVNRHLAKPDHAYSKFGSGNKTTLSEIPK 204
Query: 232 QEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEH 291
+ IDVR ELLKFH +YS+N+M + V+G+ESLD+L +V++ FSE+ENKNV +P +P H
Sbjct: 205 SKNIDVRDELLKFHKQWYSANIMCLAVIGKESLDELEGMVLEKFSEIENKNVKVPGWPRH 264
Query: 292 PFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELK 351
P+ EE Q KIVPIKDIR+L ++F DL ++YKS P +YL HLIGHEG GS+LSEL+
Sbjct: 265 PYAEERYGQKVKIVPIKDIRSLTISFTTDDLTQFYKSGPDNYLTHLIGHEGKGSILSELR 324
Query: 352 SKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVF 411
GW N L+ G + GF FF I VDLT+EGL HV+DI+ +FQY++ LR EGP++W+
Sbjct: 325 RLGWCNDLMAGHQNTQNGFGFFDIVVDLTQEGLEHVDDIVKIVFQYLEMLRKEGPKKWIL 384
Query: 412 QECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKL 471
EC LN + FRFK+KE + + +PLEEVL A YL E+ PDLI+ +LD+L
Sbjct: 385 DECVKLNEMRFRFKEKEESENLVTHAVSSMKIFPLEEVLIAPYLSNEWSPDLIKGLLDEL 444
Query: 472 RPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFI 531
P R+ IVS+SFE D E +Y T+Y + + ++ W+N +LN KL N FI
Sbjct: 445 VPSKSRIVIVSQSFEPDCDLAEPYYKTKYGITRVAKDTVQSWENCELNENLKLALPNSFI 504
Query: 532 PTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCN 591
PTNF+I + +A +P +I DT + ++W KQD++F PKAC+ F+ +P AY+DPL+CN
Sbjct: 505 PTNFDISDVPADAPKHPTIILDTPILRVWHKQDNQFNKPKACMTFDMSNPIAYLDPLNCN 564
Query: 592 MAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMAT 651
+ ++ + LLKD LNEY Y AELA L + G+ +++G++DKQ +LL+K+++ +
Sbjct: 565 LNHMMVMLLKDQLNEYLYDAELASLKLSVMGKSCGIDFTIRGFSDKQVVLLEKLLDHLFD 624
Query: 652 FEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPR 711
F IDEKRF+I+KE Y+RSL NF+AEQP+QH++YYL LL+TE AW EL +A++ VT R
Sbjct: 625 FSIDEKRFDILKEEYVRSLKNFKAEQPYQHSIYYLALLLTENAWANMELLDAMELVTYDR 684
Query: 712 LKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTL-IEHAHTKPLLPSQLVRYREVQ 770
+ F + RLH E + GN+TKQ A I V L +A P+L Q+++ RE +
Sbjct: 685 VLNFAKEFFQRLHTECFIFGNVTKQQATDIAGRVNTRLEATNASKLPILARQMLKKREYK 744
Query: 771 LPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLG 830
L +++++ NE H + ++Y Q Q+ N+ + L Q++SEPC++ LRTKEQLG
Sbjct: 745 LLAGDSYLFEKENEFHKSSCAQLYLQCGAQTDHTNIMVNLVSQVLSEPCYDCLRTKEQLG 804
Query: 831 YIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALA 890
YIVFSG R+ NG G+R I+QS K P Y+E R+E FL T + IEDM + F++H +ALA
Sbjct: 805 YIVFSGVRKVNGANGIRIIVQSAKHPSYVEDRIENFLQTYLQVIEDMPLDEFERHKEALA 864
Query: 891 IRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPR 950
+++L+KPK + + ++++GEI Q Y+F+R+ EVA L+ ++K D + ++K+ +A D
Sbjct: 865 VKKLEKPKTIFQQFSQFYGEIAMQTYHFEREEAEVAILRKISKADFVDYFKKFIAKDGEE 924
Query: 951 RHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKP 1010
R +SVH+++++ D P + + + + I ++ FK L+P+ P
Sbjct: 925 RRVLSVHIVSQQTDENATSEAEPV-------EITNMERHKPISDIVTFKSCKELYPIALP 977
Query: 1011 HINFMA 1016
++ A
Sbjct: 978 FLDIKA 983
>ref|XP_001354132.1| GA18943-PA [Drosophila pseudoobscura]
gb|EAL29871.1| GA18943-PA [Drosophila pseudoobscura]
Length = 1055
Score = 909 bits (2348), Expect = 0.0, Method: Composition-based stats.
Identities = 449/987 (45%), Positives = 656/987 (66%), Gaps = 27/987 (2%)
Query: 52 NHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCE 111
N+I KS +D R+YRGL+L NG+KVLLISDP TD S+AAL V +G +SDP N+ GL+HFCE
Sbjct: 67 NNIEKSQQDTRDYRGLQLENGLKVLLISDPNTDVSAAALSVQVGHMSDPQNLPGLAHFCE 126
Query: 112 HMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLC 171
HMLFLGT+KYP EN Y+ +LS+ GSSNA T T Y+F V+ + L+GALDRFAQFF+
Sbjct: 127 HMLFLGTEKYPHENGYTTYLSQSGGSSNAATYPLMTKYHFHVAPDKLDGALDRFAQFFIA 186
Query: 172 PLFDESCKDREVNAVD---------------------SEHEKNVMNDAWRLFQLEKATGN 210
PLF S +RE+NAV+ SEHEKN+ +D WR+ Q+ +
Sbjct: 187 PLFTPSATEREINAVNTQLHPRFTQIWALTKNSLQVNSEHEKNLPSDLWRIKQVHRHLAK 246
Query: 211 PKHPFSKFGTGNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNL 270
P H +SKFG+GNK TL P IDVR+ELLKFH +YS+N+M + V+G+ESL++L ++
Sbjct: 247 PDHAYSKFGSGNKTTLSEIPKSMNIDVREELLKFHKEWYSANIMCLAVIGKESLNELESM 306
Query: 271 VVKLFSEVENKNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNP 330
V++ FSE+ENK+V +PE+P HP+ E+ Q KIVPIKD+R+L ++F DL K+YKS P
Sbjct: 307 VMEKFSEIENKSVAVPEWPRHPYGEDRYGQKVKIVPIKDVRSLTISFTTDDLTKFYKSGP 366
Query: 331 GHYLGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDI 390
+YL HLIGHEG GS+LSEL+ GW N L+ G + GF FF I VDLT+EGL HV+DI
Sbjct: 367 DNYLTHLIGHEGKGSILSELRRLGWCNDLMAGHQNTQNGFGFFDIVVDLTQEGLEHVDDI 426
Query: 391 ILHMFQYIQKLRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVL 450
+ +FQY++ LR EGP++W+F EC LN + FRFK+KE+P + + +PLEEVL
Sbjct: 427 VNIIFQYLRMLREEGPKKWIFDECVKLNEMRFRFKEKEQPENLVTHAVSSMQIFPLEEVL 486
Query: 451 TAEYLLEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVI 510
A YL E+RPDLI +LD+LRP R+ IVS+SFE D+ E +Y T+Y E IP +++
Sbjct: 487 IAPYLSNEWRPDLISGLLDELRPSKSRIVIVSQSFEPTCDQAEPYYKTKYGLERIPTDIV 546
Query: 511 KKWQNADLNGKFKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLP 570
+ W+ DLN KL N FIPTNF+I + + +P +I DT + ++W KQD++F P
Sbjct: 547 QSWEKCDLNENLKLSLPNSFIPTNFDIADVPSDGPKHPTIILDTPILRVWHKQDNQFNKP 606
Query: 571 KACLNFEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLS 630
KAC+ F+ +P A +DPL+CN+ ++ + LLKD LNEY Y AELA L ++ G+ +
Sbjct: 607 KACMRFDMSNPLASLDPLNCNLNHMMVMLLKDQLNEYLYDAELANLKLNVVGKSGGIDFT 666
Query: 631 VKGYNDKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLM 690
+ G++DKQ +LL+K+++ + F +DEKRF+I+KE Y+RSL NF+AEQP+QH++YYL LL+
Sbjct: 667 IHGFSDKQVVLLEKLLDHLFDFRVDEKRFDILKEEYVRSLKNFKAEQPYQHSIYYLALLL 726
Query: 691 TEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTL- 749
TE AW EL +A++ VT R+ F + RLH E + GN+TKQ A + V L
Sbjct: 727 TENAWANVELLDAMELVTYDRVNNFAKEFFQRLHTECFIFGNVTKQHATEVAGRVNTRLE 786
Query: 750 IEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLE 809
+A P+L Q+++ RE +L +++++ NE H + ++Y Q Q+ N+ +
Sbjct: 787 ATNASKLPILARQMLKKREYKLLAGDSYLFEKENEYHKSSCTQLYLQCGAQTDHTNIMVN 846
Query: 810 LFCQIISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLIT 869
L Q++SEPC++ LRTKEQLGYIVFSG R+ NG G+R I+QS K P ++E R+E FL T
Sbjct: 847 LVSQVLSEPCYDCLRTKEQLGYIVFSGVRKVNGANGIRIIVQSAKHPTFVEDRIENFLQT 906
Query: 870 MEKSIEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLK 929
++IEDM + F++H +ALA+++L+KPK + + +++GEI Q Y+F+R+ EVA L+
Sbjct: 907 YLQAIEDMPLDEFERHKEALAVKKLEKPKTIFQQFIQFYGEIAMQTYHFEREEAEVAILR 966
Query: 930 TLTKEDIIKFYKEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQP 989
++K D + ++K+ +A D R +SVH+++++ D V E + + ++ + +
Sbjct: 967 KISKSDFVDYFKKFIAKDGGERRVLSVHIVSKQTDEN--VSEPKEEEPLEITN---MERH 1021
Query: 990 EVIQNMTEFKRGLPLFPLVKPHINFMA 1016
+ I ++ FK L+P+ P ++ A
Sbjct: 1022 KCISDIVAFKSCKELYPIALPFLDIKA 1048
>ref|XP_001896776.1| insulin-degrading enzyme [Brugia malayi]
gb|EDP34377.1| insulin-degrading enzyme, putative [Brugia malayi]
Length = 990
Score = 827 bits (2137), Expect = 0.0, Method: Composition-based stats.
Identities = 424/968 (43%), Positives = 619/968 (63%), Gaps = 15/968 (1%)
Query: 52 NHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCE 111
++I KS EDKREYRGLEL NG++VLLISDP TDKS+A++DV++G L DP + GL+HFCE
Sbjct: 17 DNIIKSKEDKREYRGLELTNGLRVLLISDPKTDKSAASMDVNVGHLMDPWELPGLAHFCE 76
Query: 112 HMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLC 171
HMLFLGT KYP ENEYS+F+S H G +NA+T+ +HTNY+FD++ EHL GALDRF QFFLC
Sbjct: 77 HMLFLGTDKYPSENEYSKFISSHGGITNAYTATDHTNYHFDIAPEHLHGALDRFVQFFLC 136
Query: 172 PLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPN 231
P F ES +REV AVDSE ++ ND WR+ Q+E++ P H + KFGTGN+ TL
Sbjct: 137 PQFTESATEREVRAVDSEFSNSLFNDQWRMLQVERSLSKPSHDYGKFGTGNRTTLMVEAL 196
Query: 232 QEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKL-FSEVENKNVPLPEFPE 290
+ GI+ R+ LL+FH YYSS++M+ +LG+ESLD L +V L F ++E KNV + E
Sbjct: 197 KNGIEPRKALLEFHKTYYSSDIMSFAILGKESLDQLEQMVTSLSFGDIEKKNVTRKIWNE 256
Query: 291 HPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSEL 350
P+ EE L ++VP+KD+R L +TFPI D + Y+S P HY+ HLIGHEGPGSLLSEL
Sbjct: 257 GPYGEEQLGVKVELVPVKDLRYLTLTFPIRDYRDDYRSWPAHYVSHLIGHEGPGSLLSEL 316
Query: 351 KSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWV 410
K +GWVN+L G + ARGF F I+VDL+EEGLLH +DI+ +F + ++ GP +W+
Sbjct: 317 KRRGWVNSLSAGDRLLARGFGNFSISVDLSEEGLLHTDDIVKLVFNEVGLVKQTGPLKWI 376
Query: 411 FQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDK 470
F E K L + FRFKDKE P Y ++I+ L P E+V+ A+Y ++ ++PDLI+ +++
Sbjct: 377 FDELKQLQEIKFRFKDKESPLNYVTQISSELQRIPFEDVICADYKMDLYKPDLIKEFVEE 436
Query: 471 LRPENVRVAIVSKSFEGKTDR-TEEWYGTQYKQEAIPDEVIKKWQNA--DLNGKFKLPTK 527
++PEN+ A++S+ + GK E+WYGT+Y I +V+ K+ A + F LP K
Sbjct: 437 IKPENMFYAVISQEYAGKEHNIKEKWYGTEYNNTKIDKKVLSKFNEALTQIPDFFSLPAK 496
Query: 528 NEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDP 587
NE+I T F++ P EK P L+ + +LWF QD+ F LPK F SP + DP
Sbjct: 497 NEYIATKFDLKPREK-TKKIPYLVVNNDWCRLWFMQDNDFKLPKLSTRIAFKSPMMHSDP 555
Query: 588 LHCNMAYLYLELLKDSLNEYAYAAELAGL--SYDLQNTIYGMYLSVKGYNDKQPILLKKI 645
L+ ++ +++ L+D+++E Y A LAGL S+DLQ+ YG+ L V GY++KQP + +
Sbjct: 556 LNSYLSAMFVICLQDAISEETYNAHLAGLKSSFDLQS--YGITLHVSGYDEKQPKYINDL 613
Query: 646 IEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALD 705
I++ TF DE+R++++KE + R+L NFR QP+ A YY LL+ W+K+E+ +
Sbjct: 614 IQRFITFVPDEERYKVLKETFCRNLRNFRQSQPYMQAHYYSTLLLGSRQWSKEEVLACAE 673
Query: 706 DVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVR 765
+ + +L+ F + L L IEAL++GN T++ + I+ V + L S+L +
Sbjct: 674 NCEVDKLRKFAHESLQALQIEALVYGNSTEKESAKILDDVXSKFKALPDARHLFDSELDQ 733
Query: 766 YREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRT 825
RE ++P +VY+ H N + QT Q T EN+ LEL Q+ +EP FN LRT
Sbjct: 734 CREHEIPKGCQYVYKAFQPTHPNASVNYLMQTGQQDTRENVLLELVVQLAAEPAFNQLRT 793
Query: 826 KEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKH 885
EQLGYIV +G RR+NG+QG+ +IQ + P ++ R+E FL+ +E M+ + F +
Sbjct: 794 TEQLGYIVHTGARRSNGVQGIELLIQGQHIPEFIVERIENFLVKFRSDLEKMSGDEFLDN 853
Query: 886 IQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLA 945
++ALA +RL+KPK + A+ +YW E+ S Y F+R++ EV L+ LTK D+I+++ + A
Sbjct: 854 VEALATKRLEKPKTMKAQAGRYWAEVDSGFYLFERNDIEVPILRKLTKADVIEYFDKHFA 913
Query: 946 VDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLF 1005
V++ R K+ V A V + + N S A PE I N+ FK L L+
Sbjct: 914 VNSSERRKLCAMVYANSETEDTV-----SKREHNAS-GDAEQLPERITNIRIFKSRLSLY 967
Query: 1006 PLVKPHIN 1013
PL +P ++
Sbjct: 968 PLPQPAVD 975
>ref|XP_001649937.1| metalloprotease [Aedes aegypti]
gb|EAT32864.1| metalloprotease [Aedes aegypti]
Length = 844
Score = 808 bits (2086), Expect = 0.0, Method: Composition-based stats.
Identities = 386/721 (53%), Positives = 521/721 (72%), Gaps = 1/721 (0%)
Query: 52 NHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCE 111
++ITKS +D R YRGL+L NG+KVLLISDPTTDKS+AAL V +G LSDP I GL+HFCE
Sbjct: 31 DNITKSQQDSRNYRGLQLENGLKVLLISDPTTDKSAAALSVAVGHLSDPDEIPGLAHFCE 90
Query: 112 HMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLC 171
HMLFLGTKKY EN+Y FLSE+ GSSNA T + T YYFDV E L ALDRF+QFF+
Sbjct: 91 HMLFLGTKKYVNENDYMSFLSENGGSSNAATYADTTKYYFDVVPEKLPEALDRFSQFFIA 150
Query: 172 PLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPN 231
PLF ES +RE+NAV SEHEKN+ D WR+ Q+ K+ +PKHP++KFGTG+K TL P
Sbjct: 151 PLFTESATEREINAVHSEHEKNLSMDVWRIRQVNKSLCDPKHPYNKFGTGSKKTLLEDPK 210
Query: 232 QEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEH 291
I++R+EL+KFH+ +YS+N+M++ V G+ESLDDL ++VV +FSE+ENKNV PE+ +
Sbjct: 211 TTNINIREELMKFHAKWYSANIMSLAVFGKESLDDLESMVVGMFSEIENKNVTSPEWKDL 270
Query: 292 PFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELK 351
P++ + L K+VP+KD R+L +TF DL+++Y++ P HY HLIGHEG GS+LSELK
Sbjct: 271 PYKNDQLATKTKVVPVKDSRSLTITFQTEDLEQHYRAGPEHYASHLIGHEGAGSILSELK 330
Query: 352 SKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVF 411
+KGW N LVGG RGF FF + VDLT++G HV+DI+ +FQYI L+ EGPQ+W+F
Sbjct: 331 AKGWCNNLVGGYNTIGRGFGFFEVMVDLTQDGFEHVDDIVKIIFQYINMLKKEGPQKWIF 390
Query: 412 QECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKL 471
+E DL + FRFKDKE P S + + YPLEEVL A YL+ E+RPDLIE + +K
Sbjct: 391 EEYCDLCEMQFRFKDKENPLTLVSSVVHSMQSYPLEEVLAAPYLISEWRPDLIEDLWNKF 450
Query: 472 RPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFI 531
P+N R+ +V + + K EEWYGT+Y E I +V++ W +DLNG LP +N FI
Sbjct: 451 YPQNARITVVGQKCQAKATCEEEWYGTKYSTEKIDAKVLEDWAKSDLNGNLHLPERNPFI 510
Query: 532 PTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCN 591
PTNF++L ++ + P +I +T M ++WFKQD +F PK +N +F SP Y DPL+CN
Sbjct: 511 PTNFDLLAVDADIESIPVIIHNTPMMRVWFKQDVEFLKPKTLMNLDFCSPIVYSDPLNCN 570
Query: 592 MAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMAT 651
+ +L+++L KD LNEY YAA LAGL + NT YG+ +S+ GY+ KQ ILL+K+++ M
Sbjct: 571 LTHLFVQLFKDHLNEYLYAAGLAGLRLGVANTTYGVSVSIGGYSHKQHILLEKVLDDMFN 630
Query: 652 FEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPR 711
F+IDEKRFEI+KE Y+R+L N++AEQP+QHA+YYL LL+TE AW+K EL +A + VT+ R
Sbjct: 631 FKIDEKRFEILKEQYIRNLKNYQAEQPYQHAVYYLALLLTEQAWSKQELIDATELVTVDR 690
Query: 712 LKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIE-HAHTKPLLPSQLVRYREVQ 770
L+ FI +LLSR+H+E ++GN+ K+ AL + VED L + A+ PLL QL+ RE +
Sbjct: 691 LRTFIDELLSRMHVECFIYGNVNKEKALEMSSKVEDKLKKTDANVVPLLARQLMLKREYK 750
Query: 771 L 771
L
Sbjct: 751 L 751
>ref|XP_001674236.1| Hypothetical protein CBG09322 [Caenorhabditis briggsae AF16]
emb|CAP29245.1| Hypothetical protein CBG09322 [Caenorhabditis briggsae]
Length = 994
Score = 778 bits (2008), Expect = 0.0, Method: Composition-based stats.
Identities = 407/966 (42%), Positives = 610/966 (63%), Gaps = 12/966 (1%)
Query: 54 ITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHM 113
I K +D REYRGLEL NG+++LL+SDP+TDKS+AALDV +G L DP + GL+HFCEHM
Sbjct: 16 IVKGAQDVREYRGLELTNGLRILLVSDPSTDKSAAALDVKVGHLMDPWELPGLAHFCEHM 75
Query: 114 LFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPL 173
LFLGT KYP ENEYS+FLS HAG+SNA+T+ +HTNY+FDV + L GALDRF QFFL P
Sbjct: 76 LFLGTAKYPSENEYSKFLSAHAGNSNAYTATDHTNYHFDVKPDQLSGALDRFVQFFLSPQ 135
Query: 174 FDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQE 233
F ES +REV AVDSEH N+ ND+WR Q++++ P H + KFGTGNK TL ++
Sbjct: 136 FTESATEREVCAVDSEHSNNLNNDSWRFLQVDRSRSKPGHDYGKFGTGNKQTLLEDARKK 195
Query: 234 GIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTN-LVVKLFSEVENKNVPLPEFPEHP 292
GI+ R LL+FH +YSS++M+ C++G+ESLD L + L F +ENK V + + P
Sbjct: 196 GIEPRDALLQFHKKWYSSDIMSCCIIGKESLDVLESYLGTYEFDAIENKKVTRQVWKDFP 255
Query: 293 FQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKS 352
+ E L + ++VPIKD R L ++FP PDL Y S PGHY+ HLIGHEGPGSLLSELK
Sbjct: 256 YGPEQLGKKVEVVPIKDTRMLSISFPFPDLNTEYNSQPGHYISHLIGHEGPGSLLSELKR 315
Query: 353 KGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQ 412
+GWV++L A GF +++ +DL+ +GL HV++II MF YI L+ GP++W+ +
Sbjct: 316 RGWVSSLQSDSHTQASGFGVYMVTMDLSTDGLDHVDEIIQLMFNYIGMLQTAGPKQWIHE 375
Query: 413 ECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLR 472
E +L+AV FRFKDKE+P +A L Y P E++L+++YLL ++ P+ I+ +LD L+
Sbjct: 376 ELAELSAVKFRFKDKEQPMSMAINVASSLQYIPFEDILSSKYLLTKYDPERIKQLLDTLK 435
Query: 473 PENVRVAIVSKSFEGKT-DRTEEWYGTQYKQEAIPDEVIKKWQNA--DLNGKFKLPTKNE 529
PEN+ V +VS++F+G+ + TE YGT++K I E ++K++NA + LP KNE
Sbjct: 436 PENMYVRVVSQTFKGQEGNTTEPVYGTEFKMADIDKETMQKYENALKTSHHALHLPEKNE 495
Query: 530 FIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLH 589
+I T F+ P E +P LI D + S++WFKQDD++ +PK F SP DP
Sbjct: 496 YIATKFDQKPRETIKNEHPRLIVDDSWSRVWFKQDDEYNMPKQETKFGLTSPVVSQDPRS 555
Query: 590 CNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKM 649
++ L+L L D+L E Y A+LAGL L+++ +G+ + V GY++KQ + K + ++M
Sbjct: 556 SLLSSLWLWCLSDTLAEETYNADLAGLKCQLESSPFGVQMRVYGYDEKQSLFTKHLTKRM 615
Query: 650 ATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTL 709
A F+ID+ RF+++ E+ R+L N QP+ + +Y +L++ + W+K++L ++VTL
Sbjct: 616 ANFKIDKTRFDVLFESLKRALTNHAFSQPYSLSQHYNQLIVLDKVWSKEQLLAVCENVTL 675
Query: 710 PRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIE-HAHTKPLLPSQLVRYRE 768
++ F ++ + H+E L+HGN T++ A+ + + + D L +++PL ++ RE
Sbjct: 676 EDVQNFSKEMFAAFHLELLVHGNSTEKEAIELSKELVDILKGVSPNSRPLYRNEHCPRRE 735
Query: 769 VQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQ 828
+QL + +VY+ + H+ +E+ YQ +Q+T +N + L Q+I EP FNTLRT E
Sbjct: 736 MQLNNGDEYVYRHLQKTHDVGCVEVSYQVGVQNTYDNALVGLIDQLIREPAFNTLRTNEA 795
Query: 829 LGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQA 888
LGYIV++G R G L I+Q K ++ R+E FL T+ K I++M +E F +
Sbjct: 796 LGYIVWTGSRLNCGTVSLNVIVQGPKSVDHVLERIEVFLETVRKEIDEMPQEEFDNQVSG 855
Query: 889 LAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDA 948
+ R +KPK LS ++W EI +QY+F EV LK++ KED++ Y + + DA
Sbjct: 856 MIARLEEKPKTLSGRFRRFWNEIECRQYDFAHREEEVKVLKSIKKEDVLALYDKKIRKDA 915
Query: 949 PRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLV 1008
P R K++V V + D V G I A A + + ++ + + ++ LPL+
Sbjct: 916 PERRKLAVFVHGKGEDREKVDG-------IVKKNAEAGKKEKEVEYVDQLRQFLPLYGRP 968
Query: 1009 KPHINF 1014
P IN
Sbjct: 969 IPAINL 974
>ref|XP_505854.1| hypothetical protein [Yarrowia lipolytica]
emb|CAG78665.1| unnamed protein product [Yarrowia lipolytica CLIB122]
Length = 1007
Score = 762 bits (1967), Expect = 0.0, Method: Composition-based stats.
Identities = 390/949 (41%), Positives = 596/949 (62%), Gaps = 20/949 (2%)
Query: 50 IGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHF 109
I + + K D R+YR + LANG++ LLI DP D++SAA+DV++GS SDP + GL+HF
Sbjct: 49 IESSVDKPVTDDRQYRVITLANGLEALLIHDPDADRASAAMDVNVGSFSDPVGLPGLAHF 108
Query: 110 CEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFF 169
CEH+LF+GT+KYP+EN+YS +LSEH+GSSNA+T+ E TNY+FDV HE+LEGA DRFAQFF
Sbjct: 109 CEHLLFMGTEKYPEENDYSTYLSEHSGSSNAYTASEETNYFFDVGHEYLEGAFDRFAQFF 168
Query: 170 LCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETR 229
+ PLF S KDRE+ AVDSE++KN+ ND WRLFQLE++ NP HP+++F TGN TL T
Sbjct: 169 VAPLFAASAKDREIQAVDSENKKNLQNDMWRLFQLERSLSNPDHPYNRFSTGNYETLHTE 228
Query: 230 PNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFP 289
P ++G+DVR+ELLKF+ A YSSN+M + +LGRESLD L + VV+ S V N N LP++
Sbjct: 229 PLEKGMDVREELLKFYKASYSSNIMKLVILGRESLDTLQSWVVEKLSSVVNTNATLPDYG 288
Query: 290 EHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSE 349
E L L K PI D +++ VTFP+PD +++++S+PGHY HL+GHEGPGS+L
Sbjct: 289 VPLLTEGELGTLVKAKPIMDTKSIEVTFPVPDTREHWESHPGHYYSHLVGHEGPGSILFF 348
Query: 350 LKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEW 409
LK+KGWV++ G + RG F I+ +LT+ G+ H +D+++H+F+Y++ LR E QEW
Sbjct: 349 LKNKGWVSSCSSGAVQVCRGAGVFTISCELTDAGMNHYKDVVVHIFEYLRMLRDEPVQEW 408
Query: 410 VFQECKDLNAVAFRFKDKERPRGYTSKIAGIL--HYYPLEEVLTAEYLLEEFRPDLIEMV 467
++ E +D+ FRF+ KE P TS++A +L ++ P + +L++ L ++ P++I+
Sbjct: 409 IYDEMRDVALANFRFRQKENPSSTTSRLATVLQKNHLPRQYLLSSS-LFRKYSPEVIQAF 467
Query: 468 LDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTK 527
+N ++ +V + EG ++TE+WYGTQY + I + +++ ++A N LP
Sbjct: 468 GRHFTTDNFKIFLVGQELEG-LNQTEKWYGTQYSNDKIDADWMRRVKSAGRNPDLHLPAP 526
Query: 528 NEFIPTNFEIL-PLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVD 586
NEFIPT+F + KE +P L+++T +LW K+DD F +PKA + +P + D
Sbjct: 527 NEFIPTDFSVPDKRAKEPQTHPTLLRNTDYVRLWHKRDDTFLVPKATVRIRLKNPIGHAD 586
Query: 587 PLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKII 646
P + L +E++ D L E+AYAAE+AGL Y + + G+ + + GYN K LL++I+
Sbjct: 587 PFNSVKTTLLIEVVTDLLLEFAYAAEIAGLKYGVLASRDGVEIDLNGYNHKLETLLERIL 646
Query: 647 EKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDD 706
K+ F++D+ RF I+KE ++ NF P+ ++ + L+ + WT E +E ++
Sbjct: 647 LKIKNFDVDQSRFNIVKETVSKTYKNFGYNVPYAQVAHHSQYLLNDHTWTVQEKREKIEQ 706
Query: 707 VTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRY 766
+T + +F+P+ L L +E L+ GN+ K+ A+ I Q + + L PL PSQLV
Sbjct: 707 LTREDIISFVPEFLRHLQVETLVVGNLAKEDAVSISQTISNVL----KPAPLSPSQLVNP 762
Query: 767 REVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSE---NMFLELFCQIISEPCFNTL 823
R LPD F Y E N I Y + S LE+ QI EP FN L
Sbjct: 763 RSFLLPDSSAFHYDVDLEDKANVNSVIDYMVQVGKFSNIRTRALLEVLAQIGQEPSFNQL 822
Query: 824 RTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLI-TMEKSIEDMTEEAF 882
RTKEQLGY+VFSG + R +IQSEK YLESR+E +LI + I +M+E F
Sbjct: 823 RTKEQLGYVVFSGIKSTRTTLLYRVLIQSEKTCSYLESRIENYLIEILGPMIRNMSEAEF 882
Query: 883 QKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKE 942
KH+ A+ ++L+K K +S E ++YW +IIS Y+F ++ + +KTL K D+++FY
Sbjct: 883 DKHVAAVVAKKLEKRKNISEEASRYWSQIISGYYDFKQNFKDAEEIKTLKKADLVEFYDR 942
Query: 943 MLAVDAPRRHKVSVHVLAREM-------DSCPVVGEFPCQNDINLSQAP 984
+ + R K+ +++ ++ +S P++ +N +++++AP
Sbjct: 943 YVDPASKLRSKLVINLKSQVTKDEGQIPNSVPIIDHAAFKNSLSMTEAP 991
>ref|NP_741542.1| F44E7.4b [Caenorhabditis elegans]
gb|AAM45374.1|AF016421_5 Hypothetical protein F44E7.4b [Caenorhabditis elegans]
Length = 1051
Score = 760 bits (1962), Expect = 0.0, Method: Composition-based stats.
Identities = 397/916 (43%), Positives = 575/916 (62%), Gaps = 5/916 (0%)
Query: 54 ITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHM 113
I K +D REYRGLEL NGI+VLL+SDPTTDKS+AALDV +G L DP + GL+HFCEHM
Sbjct: 75 IVKGAQDAREYRGLELTNGIRVLLVSDPTTDKSAAALDVKVGHLMDPWELPGLAHFCEHM 134
Query: 114 LFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPL 173
LFLGT KYP ENEYS+FL+ HAGSSNA+TS +HTNY+FDV + L GALDRF QFFL P
Sbjct: 135 LFLGTAKYPSENEYSKFLAAHAGSSNAYTSSDHTNYHFDVKPDQLPGALDRFVQFFLSPQ 194
Query: 174 FDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQE 233
F ES +REV AVDSEH N+ ND WR Q++++ P H + KFGTGNK TL ++
Sbjct: 195 FTESATEREVCAVDSEHSNNLNNDLWRFLQVDRSRSKPGHDYGKFGTGNKQTLLEDARKK 254
Query: 234 GIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKL-FSEVENKNVPLPEFPEHP 292
GI+ R LL+FH +YSS++M C++G+E L+ L + + L F +ENK V + E P
Sbjct: 255 GIEPRDALLQFHKKWYSSDIMTCCIVGKEPLNVLESYLGTLEFDAIENKKVERKVWEEFP 314
Query: 293 FQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKS 352
+ + L + +VPIKD R + ++FP PDL + S PGHY+ HLIGHEGPGSLLSELK
Sbjct: 315 YGPDQLAKRIDVVPIKDTRLVSISFPFPDLNGEFLSQPGHYISHLIGHEGPGSLLSELKR 374
Query: 353 KGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQ 412
GWV++L A GF + + +DL+ EGL HV++II MF YI L++ GP++WV
Sbjct: 375 LGWVSSLQSDSHTQAAGFGVYNVTMDLSTEGLEHVDEIIQLMFNYIGMLQSAGPKQWVHD 434
Query: 413 ECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLR 472
E +L+AV FRFKDKE+P +A L Y P E +L++ YLL ++ P+ I+ +L L
Sbjct: 435 ELAELSAVKFRFKDKEQPMTMAINVAASLQYIPFEHILSSRYLLTKYEPERIKELLSMLS 494
Query: 473 PENVRVAIVSKSFEGKTDRTEE-WYGTQYKQEAIPDEVIKKWQNA--DLNGKFKLPTKNE 529
P N++V +VS+ F+G+ T E YGT+ K I E +KK++NA + LP KNE
Sbjct: 495 PANMQVRVVSQKFKGQEGNTNEPVYGTEMKVTDISPETMKKYENALKTSHHALHLPEKNE 554
Query: 530 FIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLH 589
+I TNF+ P E +P LI D S++WFKQDD++ +PK +P +P
Sbjct: 555 YIATNFDQKPRESVKNEHPRLISDDGWSRVWFKQDDEYNMPKQETKLALTTPMVAQNPRM 614
Query: 590 CNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKM 649
++ L+L L D+L E Y A+LAGL L+++ +G+ + V GY++KQ + K + +M
Sbjct: 615 SLLSSLWLWCLSDTLAEETYNADLAGLKCQLESSPFGVQMRVYGYDEKQALFAKHLANRM 674
Query: 650 ATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTL 709
F+ID+ RF+++ E+ R+L N QP+ +Y +LL+ + W+K++L D VTL
Sbjct: 675 TNFKIDKTRFDVLFESLKRALTNHAFSQPYLLTQHYNQLLIVDKVWSKEQLLAVCDSVTL 734
Query: 710 PRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHA-HTKPLLPSQLVRYRE 768
++ F ++L H+E +HGN T++ A+ + + + D L A +++PL ++ RE
Sbjct: 735 EDVQGFAKEMLQAFHMELFVHGNSTEKEAIQLSKELMDVLKSAAPNSRPLYRNEHNPRRE 794
Query: 769 VQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQ 828
+QL + +VY+ + H+ +E+ YQ +Q+T +N + L Q+I EP FNTLRT E
Sbjct: 795 LQLNNGDEYVYRHLQKTHDVGCVEVTYQIGVQNTYDNAVVGLIDQLIREPAFNTLRTNEA 854
Query: 829 LGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQA 888
LGYIV++G R G L I+Q K ++ R+E FL ++ K I +M +E F +
Sbjct: 855 LGYIVWTGSRLNCGTVALNVIVQGPKSVDHVLERIEVFLESVRKEIAEMPQEEFDNQVSG 914
Query: 889 LAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDA 948
+ R +KPK LS+ ++W EI +QYNF R EVA LKT+ K+D+++ + + + DA
Sbjct: 915 MIARLEEKPKTLSSRFRRFWNEIECRQYNFARREEEVALLKTIKKDDVLELFDKKIRKDA 974
Query: 949 PRRHKVSVHVLAREMD 964
R K++V V + D
Sbjct: 975 AERRKLAVFVHGKNED 990
>ref|XP_759404.1| hypothetical protein UM03257.1 [Ustilago maydis 521]
gb|EAK84184.1| hypothetical protein UM03257.1 [Ustilago maydis 521]
Length = 1292
Score = 757 bits (1955), Expect = 0.0, Method: Composition-based stats.
Identities = 394/914 (43%), Positives = 570/914 (62%), Gaps = 18/914 (1%)
Query: 57 SPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFL 116
S +D YR + LANG++ L+I DP TDKSSAA+D+ +G LSDP + GL+HFCEH+LF+
Sbjct: 218 SAQDDLRYRLVRLANGLEALVIQDPKTDKSSAAMDIRVGHLSDPEELQGLAHFCEHLLFM 277
Query: 117 GTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDE 176
GTKKYP+ENEYS++LS H+G SNA+T ++TNY+FDVS +H EGALDRFAQFFL PLFD
Sbjct: 278 GTKKYPRENEYSEYLSNHSGGSNAYTGMDNTNYFFDVSPDHFEGALDRFAQFFLEPLFDP 337
Query: 177 SCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGID 236
SC +RE+ AVDSEH+KN+ +D WR FQL+K+ +P HP+S FGTGN TL P +G+D
Sbjct: 338 SCSEREIKAVDSEHKKNLQSDMWRGFQLDKSLSDPSHPYSHFGTGNYQTLWEDPKSKGVD 397
Query: 237 VRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEE 296
VR ELLKFH YYS+N+M + VLGRE LD LT+ V++ FS V N P+F P +
Sbjct: 398 VRDELLKFHDQYYSANVMKLVVLGREDLDQLTSWVIEKFSGVRNTGREPPQFDRSPLTTQ 457
Query: 297 HLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWV 356
L++ ++D+R L + FPIPD +++S PGH+L H IGHEG GS+LS LK KGW
Sbjct: 458 QLQKQIFAKSVRDVRKLKIAFPIPDQGPHFRSKPGHFLSHFIGHEGEGSILSHLKKKGWC 517
Query: 357 NTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKD 416
+ L G A GF FF I++DLT+EGL + E ++ +F+YI LR+ ++W E
Sbjct: 518 DRLSAGATGDANGFEFFKISIDLTQEGLDNHEKVVEAVFKYIHLLRSSNLEQWTHDEVAQ 577
Query: 417 LNAVAFRFKDKERPRGYTSKIAGILHY-YPLEEVLTAEYLLEEFRPDLIEMVLDKLRPEN 475
L+ + FRFK+K P Y S A + YP E +L+ +L +F +LI LD L P+N
Sbjct: 578 LSELMFRFKEKIDPADYASSTATQMQMPYPREWILSGGWLTRDFDRELITQTLDHLTPQN 637
Query: 476 VRVAIVSKSF-EGKT--DRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIP 532
RV +++K+ +G T + E+WYGT+Y + +P +++ + AD LP N FIP
Sbjct: 638 CRVVVMAKTLPDGSTSWESKEKWYGTEYSIKPLPQQLLTQ-TPADFE-DLHLPRPNSFIP 695
Query: 533 TNFEIL-PLE----KEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDP 587
NF+ PL K+ TP P L+ D ++W K DD+F LPKA + F +P P
Sbjct: 696 VNFDFKGPLAEAQGKKPTPRPQLVLDNESIRVWHKLDDRFGLPKANVFFVLRNPLINATP 755
Query: 588 LHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIE 647
L + +EL+ DSL EY+Y A LAGLSY L + + LS+ GYNDK P+L + I+E
Sbjct: 756 LTSIKTRMLIELISDSLVEYSYDASLAGLSYMLDSQDQSLALSLSGYNDKIPVLARSILE 815
Query: 648 KMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDV 707
K+A F++D +RFE++K+ RS NF E+P++HA +Y L+ E WT E L+ +
Sbjct: 816 KLANFQVDPRRFELVKDRVKRSYQNFAIEEPYRHATFYTTYLLQEKMWTPQEKLCELEQL 875
Query: 708 TLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYR 767
+ ++ F+P LL R+H+E L HGN+ K+ A+ + M +T+ ++P+ ++L+ R
Sbjct: 876 NVDEVQQFLPDLLQRMHLEVLAHGNLAKEEAIELSNMAWNTI----KSRPVNKTELLSSR 931
Query: 768 EVQLPDRGWFVYQQ--RNEVHNNCGIEIYYQTDMQSTSE-NMFLELFCQIISEPCFNTLR 824
+ LP++ ++ N + N IE Y Q + E L LF QI +EP F+ LR
Sbjct: 932 SLLLPEKSNKIWNLPVTNAANVNSAIEYYVQIGEPTDVEMRATLSLFSQIANEPVFDQLR 991
Query: 825 TKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQK 884
TKEQLGY+VFSG RR+ G G R I+QSE+ YLE RV+AFL +++ MTE+ F+
Sbjct: 992 TKEQLGYLVFSGIRRSTGSLGWRVIVQSERDAPYLEGRVDAFLDQFRATLDKMTEQEFEA 1051
Query: 885 HIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEML 944
H +++ ++L+ K L E ++W + Y+F +V + TKE ++ + + +
Sbjct: 1052 HKRSIIHKKLENVKNLVEESTRFWSPVFGGNYDFLARYADVEAIAQTTKEQVVDLFMKYI 1111
Query: 945 AVDAPRRHKVSVHV 958
+P R K+SVH+
Sbjct: 1112 HPSSPTRSKLSVHL 1125
>ref|NP_741543.1| F44E7.4a [Caenorhabditis elegans]
gb|AAC25789.1| Hypothetical protein F44E7.4a [Caenorhabditis elegans]
Length = 1067
Score = 751 bits (1938), Expect = 0.0, Method: Composition-based stats.
Identities = 398/932 (42%), Positives = 575/932 (61%), Gaps = 21/932 (2%)
Query: 54 ITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHM 113
I K +D REYRGLEL NGI+VLL+SDPTTDKS+AALDV +G L DP + GL+HFCEHM
Sbjct: 75 IVKGAQDAREYRGLELTNGIRVLLVSDPTTDKSAAALDVKVGHLMDPWELPGLAHFCEHM 134
Query: 114 LFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPL 173
LFLGT KYP ENEYS+FL+ HAGSSNA+TS +HTNY+FDV + L GALDRF QFFL P
Sbjct: 135 LFLGTAKYPSENEYSKFLAAHAGSSNAYTSSDHTNYHFDVKPDQLPGALDRFVQFFLSPQ 194
Query: 174 FDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQE 233
F ES +REV AVDSEH N+ ND WR Q++++ P H + KFGTGNK TL ++
Sbjct: 195 FTESATEREVCAVDSEHSNNLNNDLWRFLQVDRSRSKPGHDYGKFGTGNKQTLLEDARKK 254
Query: 234 GIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKL-FSEVENKNVPLPEFPEHP 292
GI+ R LL+FH +YSS++M C++G+E L+ L + + L F +ENK V + E P
Sbjct: 255 GIEPRDALLQFHKKWYSSDIMTCCIVGKEPLNVLESYLGTLEFDAIENKKVERKVWEEFP 314
Query: 293 FQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKS 352
+ + L + +VPIKD R + ++FP PDL + S PGHY+ HLIGHEGPGSLLSELK
Sbjct: 315 YGPDQLAKRIDVVPIKDTRLVSISFPFPDLNGEFLSQPGHYISHLIGHEGPGSLLSELKR 374
Query: 353 KGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQ 412
GWV++L A GF + + +DL+ EGL HV++II MF YI L++ GP++WV
Sbjct: 375 LGWVSSLQSDSHTQAAGFGVYNVTMDLSTEGLEHVDEIIQLMFNYIGMLQSAGPKQWVHD 434
Query: 413 ECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLR 472
E +L+AV FRFKDKE+P +A L Y P E +L++ YLL ++ P+ I+ +L L
Sbjct: 435 ELAELSAVKFRFKDKEQPMTMAINVAASLQYIPFEHILSSRYLLTKYEPERIKELLSMLS 494
Query: 473 PENVRVAIVSKSFEGKTDRTEE-WYGTQYKQEAIPDEVIKKWQNA--DLNGKFKLPTKNE 529
P N++V +VS+ F+G+ T E YGT+ K I E +KK++NA + LP KNE
Sbjct: 495 PANMQVRVVSQKFKGQEGNTNEPVYGTEMKVTDISPETMKKYENALKTSHHALHLPEKNE 554
Query: 530 FIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLH 589
+I TNF+ P E +P LI D S++WFKQDD++ +PK +P +P
Sbjct: 555 YIATNFDQKPRESVKNEHPRLISDDGWSRVWFKQDDEYNMPKQETKLALTTPMVAQNPRM 614
Query: 590 CNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYG----------------MYLSVKG 633
++ L+L L D+L E Y A+LAGL L+++ +G + L V G
Sbjct: 615 SLLSSLWLWCLSDTLAEETYNADLAGLKCQLESSPFGVQMRVSNRREAERHASLTLHVYG 674
Query: 634 YNDKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEV 693
Y++KQ + K + +M F+ID+ RF+++ E+ R+L N QP+ +Y +LL+ +
Sbjct: 675 YDEKQALFAKHLANRMTNFKIDKTRFDVLFESLKRALTNHAFSQPYLLTQHYNQLLIVDK 734
Query: 694 AWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHA 753
W+K++L D VTL ++ F ++L H+E +HGN T++ A+ + + + D L A
Sbjct: 735 VWSKEQLLAVCDSVTLEDVQGFAKEMLQAFHMELFVHGNSTEKEAIQLSKELMDVLKSAA 794
Query: 754 -HTKPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFC 812
+++PL ++ RE+QL + +VY+ + H+ +E+ YQ +Q+T +N + L
Sbjct: 795 PNSRPLYRNEHNPRRELQLNNGDEYVYRHLQKTHDVGCVEVTYQIGVQNTYDNAVVGLID 854
Query: 813 QIISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEK 872
Q+I EP FNTLRT E LGYIV++G R G L I+Q K ++ R+E FL ++ K
Sbjct: 855 QLIREPAFNTLRTNEALGYIVWTGSRLNCGTVALNVIVQGPKSVDHVLERIEVFLESVRK 914
Query: 873 SIEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLT 932
I +M +E F + + R +KPK LS+ ++W EI +QYNF R EVA LKT+
Sbjct: 915 EIAEMPQEEFDNQVSGMIARLEEKPKTLSSRFRRFWNEIECRQYNFARREEEVALLKTIK 974
Query: 933 KEDIIKFYKEMLAVDAPRRHKVSVHVLAREMD 964
K+D+++ + + + DA R K++V V + D
Sbjct: 975 KDDVLELFDKKIRKDAAERRKLAVFVHGKNED 1006
>ref|NP_504514.2| F44E7.4c [Caenorhabditis elegans]
gb|AAO12429.1| Hypothetical protein F44E7.4c [Caenorhabditis elegans]
Length = 1008
Score = 750 bits (1937), Expect = 0.0, Method: Composition-based stats.
Identities = 398/932 (42%), Positives = 575/932 (61%), Gaps = 21/932 (2%)
Query: 54 ITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHM 113
I K +D REYRGLEL NGI+VLL+SDPTTDKS+AALDV +G L DP + GL+HFCEHM
Sbjct: 16 IVKGAQDAREYRGLELTNGIRVLLVSDPTTDKSAAALDVKVGHLMDPWELPGLAHFCEHM 75
Query: 114 LFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPL 173
LFLGT KYP ENEYS+FL+ HAGSSNA+TS +HTNY+FDV + L GALDRF QFFL P
Sbjct: 76 LFLGTAKYPSENEYSKFLAAHAGSSNAYTSSDHTNYHFDVKPDQLPGALDRFVQFFLSPQ 135
Query: 174 FDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQE 233
F ES +REV AVDSEH N+ ND WR Q++++ P H + KFGTGNK TL ++
Sbjct: 136 FTESATEREVCAVDSEHSNNLNNDLWRFLQVDRSRSKPGHDYGKFGTGNKQTLLEDARKK 195
Query: 234 GIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKL-FSEVENKNVPLPEFPEHP 292
GI+ R LL+FH +YSS++M C++G+E L+ L + + L F +ENK V + E P
Sbjct: 196 GIEPRDALLQFHKKWYSSDIMTCCIVGKEPLNVLESYLGTLEFDAIENKKVERKVWEEFP 255
Query: 293 FQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKS 352
+ + L + +VPIKD R + ++FP PDL + S PGHY+ HLIGHEGPGSLLSELK
Sbjct: 256 YGPDQLAKRIDVVPIKDTRLVSISFPFPDLNGEFLSQPGHYISHLIGHEGPGSLLSELKR 315
Query: 353 KGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQ 412
GWV++L A GF + + +DL+ EGL HV++II MF YI L++ GP++WV
Sbjct: 316 LGWVSSLQSDSHTQAAGFGVYNVTMDLSTEGLEHVDEIIQLMFNYIGMLQSAGPKQWVHD 375
Query: 413 ECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLR 472
E +L+AV FRFKDKE+P +A L Y P E +L++ YLL ++ P+ I+ +L L
Sbjct: 376 ELAELSAVKFRFKDKEQPMTMAINVAASLQYIPFEHILSSRYLLTKYEPERIKELLSMLS 435
Query: 473 PENVRVAIVSKSFEGKTDRTEE-WYGTQYKQEAIPDEVIKKWQNA--DLNGKFKLPTKNE 529
P N++V +VS+ F+G+ T E YGT+ K I E +KK++NA + LP KNE
Sbjct: 436 PANMQVRVVSQKFKGQEGNTNEPVYGTEMKVTDISPETMKKYENALKTSHHALHLPEKNE 495
Query: 530 FIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLH 589
+I TNF+ P E +P LI D S++WFKQDD++ +PK +P +P
Sbjct: 496 YIATNFDQKPRESVKNEHPRLISDDGWSRVWFKQDDEYNMPKQETKLALTTPMVAQNPRM 555
Query: 590 CNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYG----------------MYLSVKG 633
++ L+L L D+L E Y A+LAGL L+++ +G + L V G
Sbjct: 556 SLLSSLWLWCLSDTLAEETYNADLAGLKCQLESSPFGVQMRVSNRREAERHASLTLHVYG 615
Query: 634 YNDKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEV 693
Y++KQ + K + +M F+ID+ RF+++ E+ R+L N QP+ +Y +LL+ +
Sbjct: 616 YDEKQALFAKHLANRMTNFKIDKTRFDVLFESLKRALTNHAFSQPYLLTQHYNQLLIVDK 675
Query: 694 AWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHA 753
W+K++L D VTL ++ F ++L H+E +HGN T++ A+ + + + D L A
Sbjct: 676 VWSKEQLLAVCDSVTLEDVQGFAKEMLQAFHMELFVHGNSTEKEAIQLSKELMDVLKSAA 735
Query: 754 -HTKPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFC 812
+++PL ++ RE+QL + +VY+ + H+ +E+ YQ +Q+T +N + L
Sbjct: 736 PNSRPLYRNEHNPRRELQLNNGDEYVYRHLQKTHDVGCVEVTYQIGVQNTYDNAVVGLID 795
Query: 813 QIISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEK 872
Q+I EP FNTLRT E LGYIV++G R G L I+Q K ++ R+E FL ++ K
Sbjct: 796 QLIREPAFNTLRTNEALGYIVWTGSRLNCGTVALNVIVQGPKSVDHVLERIEVFLESVRK 855
Query: 873 SIEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLT 932
I +M +E F + + R +KPK LS+ ++W EI +QYNF R EVA LKT+
Sbjct: 856 EIAEMPQEEFDNQVSGMIARLEEKPKTLSSRFRRFWNEIECRQYNFARREEEVALLKTIK 915
Query: 933 KEDIIKFYKEMLAVDAPRRHKVSVHVLAREMD 964
K+D+++ + + + DA R K++V V + D
Sbjct: 916 KDDVLELFDKKIRKDAAERRKLAVFVHGKNED 947
>ref|XP_001731164.1| hypothetical protein MGL_1347 [Malassezia globosa CBS 7966]
gb|EDP43950.1| hypothetical protein MGL_1347 [Malassezia globosa CBS 7966]
Length = 1110
Score = 748 bits (1932), Expect = 0.0, Method: Composition-based stats.
Identities = 399/912 (43%), Positives = 556/912 (60%), Gaps = 20/912 (2%)
Query: 60 DKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTK 119
DKREY+ + L NG++ LLI DP DK+SAA+DV +G LSDP + G++HFCEH+LF+GTK
Sbjct: 49 DKREYKLIRLENGLEALLIHDPEADKASAAMDVRVGHLSDPEGLYGMAHFCEHLLFMGTK 108
Query: 120 KYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCK 179
KYP+ENEYS++LS H+GSSNAFTS E+TNY+FDV + H EGALDRFAQFFL PLFD SC
Sbjct: 109 KYPRENEYSEYLSNHSGSSNAFTSLENTNYFFDVGYAHFEGALDRFAQFFLEPLFDPSCS 168
Query: 180 DREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQ 239
+RE+ AVDSEH+KN+ +D WR FQL+K NP HP+SKFGTGN TL +P + G+D+R
Sbjct: 169 EREIRAVDSEHKKNLQSDLWRSFQLDKTLSNPSHPYSKFGTGNLATLWEKPREMGLDIRD 228
Query: 240 ELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLK 299
ELLKFH YYS+N+M + VLGRES LT V + FS V NK +P FP P + L
Sbjct: 229 ELLKFHERYYSANMMKLVVLGRESTAKLTEWVAEKFSNVPNKQCDVPSFPGSPLSDRELG 288
Query: 300 QLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTL 359
IKD+R L +TFP P+ Y+S PG L HLIGHEG GSL S LK +GW N L
Sbjct: 289 TQVLFRTIKDVRLLDITFPFPEQADLYRSKPGQLLSHLIGHEGHGSLFSCLKQRGWANLL 348
Query: 360 VGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNA 419
G A+GF F IN+DLT EG H D++ +FQYI LRA+ ++W+++E + L+
Sbjct: 349 SAGSAIHAKGFELFKINIDLTHEGYEHYGDVVAAVFQYIDMLRAKPIEQWLYEEVQRLSE 408
Query: 420 VAFRFKDKERPRGYTSKIAGIL-HYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRV 478
+ F FK+K P Y+S +A + H P E +L+ Y+L EF LI L+ LRP+ R+
Sbjct: 409 LRFIFKEKSSPAMYSSTLASQMQHSLPPEWLLSGPYVLREFDAPLISSTLEYLRPDRCRL 468
Query: 479 AIVSKSFEG--KTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFE 536
+ + D++E WYGT+Y + E++ + L G +P +NEFIP N E
Sbjct: 469 MLAGREPPAGVSLDKSETWYGTEYTIKPFVPEMLNSCET--LQG-LSMPRENEFIPHNLE 525
Query: 537 ILPLEKEATP---YPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMA 593
+L P P L++ T ++LW KQDD+FFLPKA + +P+ P H ++
Sbjct: 526 VLREPNGDIPPSNRPQLLEHTPKARLWHKQDDRFFLPKANVAMLLRTPYVNASPRHAVLS 585
Query: 594 YLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFE 653
L +EL KD+L EY+Y A++AGL YD+ + + G+ + V GYNDK LL+ ++ + +
Sbjct: 586 RLLVELTKDALCEYSYDADVAGLHYDVDSHLDGVDIVVGGYNDKLAHLLESVLNTLTKLQ 645
Query: 654 IDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLK 713
+DEKRF I+ + R+ NF E+P QHA YY L+TE WT+ E ++DVT ++
Sbjct: 646 VDEKRFAIVHDQVRRNYENFDLEEPFQHAAYYSTYLVTERMWTQHEKLRVVNDVTAQDVQ 705
Query: 714 AFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTL----IEHAHTKPLLPSQLVRYREV 769
+I +L ++H+E L+HGN+T+ A +++ + L ++ HT P P LV
Sbjct: 706 KYISELFQQMHVEMLVHGNLTRDDARRLLETAQRHLQYEALDTHHTTP--PRSLVLSPGS 763
Query: 770 QLPDRGWFVYQQRNEVHNNCGIEIYYQT-DMQSTSENMFLELFCQIISEPCFNTLRTKEQ 828
++ W V N+ + N +E Y Q D L L QI SEPCF+ LRTKEQ
Sbjct: 764 RV---SWRV-PVANKSNVNSSLEYYCQVGDPSEVRLRATLALLAQIASEPCFDQLRTKEQ 819
Query: 829 LGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQA 888
LGY+VFSG R + G G R I+QSE+ YLESR++AF + + +M+ + F H +
Sbjct: 820 LGYLVFSGVRTSIGQMGFRVIVQSERDSDYLESRIDAFFDQLLHQLHEMSTDEFLAHRNS 879
Query: 889 LAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDA 948
L +RL+ K L+ E +YW I S Y+F + L+ LTK D+I + + +
Sbjct: 880 LIHKRLESVKNLAEETNRYWQSIHSGYYDFMNRQRDAQVLEHLTKNDVIALMEHYIHPSS 939
Query: 949 PRRHKVSVHVLA 960
PRR K H+ A
Sbjct: 940 PRRAKTVTHLQA 951
>ref|NP_001023928.1| F44E7.4d [Caenorhabditis elegans]
gb|AAT92074.1| Hypothetical protein F44E7.4d [Caenorhabditis elegans]
Length = 984
Score = 743 bits (1917), Expect = 0.0, Method: Composition-based stats.
Identities = 391/910 (42%), Positives = 564/910 (61%), Gaps = 21/910 (2%)
Query: 54 ITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHM 113
I K +D REYRGLEL NGI+VLL+SDPTTDKS+AALDV +G L DP + GL+HFCEHM
Sbjct: 75 IVKGAQDAREYRGLELTNGIRVLLVSDPTTDKSAAALDVKVGHLMDPWELPGLAHFCEHM 134
Query: 114 LFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPL 173
LFLGT KYP ENEYS+FL+ HAGSSNA+TS +HTNY+FDV + L GALDRF QFFL P
Sbjct: 135 LFLGTAKYPSENEYSKFLAAHAGSSNAYTSSDHTNYHFDVKPDQLPGALDRFVQFFLSPQ 194
Query: 174 FDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQE 233
F ES +REV AVDSEH N+ ND WR Q++++ P H + KFGTGNK TL ++
Sbjct: 195 FTESATEREVCAVDSEHSNNLNNDLWRFLQVDRSRSKPGHDYGKFGTGNKQTLLEDARKK 254
Query: 234 GIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKL-FSEVENKNVPLPEFPEHP 292
GI+ R LL+FH +YSS++M C++G+E L+ L + + L F +ENK V + E P
Sbjct: 255 GIEPRDALLQFHKKWYSSDIMTCCIVGKEPLNVLESYLGTLEFDAIENKKVERKVWEEFP 314
Query: 293 FQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKS 352
+ + L + +VPIKD R + ++FP PDL + S PGHY+ HLIGHEGPGSLLSELK
Sbjct: 315 YGPDQLAKRIDVVPIKDTRLVSISFPFPDLNGEFLSQPGHYISHLIGHEGPGSLLSELKR 374
Query: 353 KGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQ 412
GWV++L A GF + + +DL+ EGL HV++II MF YI L++ GP++WV
Sbjct: 375 LGWVSSLQSDSHTQAAGFGVYNVTMDLSTEGLEHVDEIIQLMFNYIGMLQSAGPKQWVHD 434
Query: 413 ECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLR 472
E +L+AV FRFKDKE+P +A L Y P E +L++ YLL ++ P+ I+ +L L
Sbjct: 435 ELAELSAVKFRFKDKEQPMTMAINVAASLQYIPFEHILSSRYLLTKYEPERIKELLSMLS 494
Query: 473 PENVRVAIVSKSFEGKTDRTEE-WYGTQYKQEAIPDEVIKKWQNA--DLNGKFKLPTKNE 529
P N++V +VS+ F+G+ T E YGT+ K I E +KK++NA + LP KNE
Sbjct: 495 PANMQVRVVSQKFKGQEGNTNEPVYGTEMKVTDISPETMKKYENALKTSHHALHLPEKNE 554
Query: 530 FIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLH 589
+I TNF+ P E +P LI D S++WFKQDD++ +PK +P +P
Sbjct: 555 YIATNFDQKPRESVKNEHPRLISDDGWSRVWFKQDDEYNMPKQETKLALTTPMVAQNPRM 614
Query: 590 CNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYG----------------MYLSVKG 633
++ L+L L D+L E Y A+LAGL L+++ +G + L V G
Sbjct: 615 SLLSSLWLWCLSDTLAEETYNADLAGLKCQLESSPFGVQMRVSNRREAERHASLTLHVYG 674
Query: 634 YNDKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEV 693
Y++KQ + K + +M F+ID+ RF+++ E+ R+L N QP+ +Y +LL+ +
Sbjct: 675 YDEKQALFAKHLANRMTNFKIDKTRFDVLFESLKRALTNHAFSQPYLLTQHYNQLLIVDK 734
Query: 694 AWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHA 753
W+K++L D VTL ++ F ++L H+E +HGN T++ A+ + + + D L A
Sbjct: 735 VWSKEQLLAVCDSVTLEDVQGFAKEMLQAFHMELFVHGNSTEKEAIQLSKELMDVLKSAA 794
Query: 754 -HTKPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFC 812
+++PL ++ RE+QL + +VY+ + H+ +E+ YQ +Q+T +N + L
Sbjct: 795 PNSRPLYRNEHNPRRELQLNNGDEYVYRHLQKTHDVGCVEVTYQIGVQNTYDNAVVGLID 854
Query: 813 QIISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEK 872
Q+I EP FNTLRT E LGYIV++G R G L I+Q K ++ R+E FL ++ K
Sbjct: 855 QLIREPAFNTLRTNEALGYIVWTGSRLNCGTVALNVIVQGPKSVDHVLERIEVFLESVRK 914
Query: 873 SIEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLT 932
I +M +E F + + R +KPK LS+ ++W EI +QYNF R EVA LKT+
Sbjct: 915 EIAEMPQEEFDNQVSGMIARLEEKPKTLSSRFRRFWNEIECRQYNFARREEEVALLKTIK 974
Query: 933 KEDIIKFYKE 942
K+D+++ + +
Sbjct: 975 KDDVLELFDK 984
>ref|NP_507226.2| Y70C5C.1 [Caenorhabditis elegans]
emb|CAI46605.1| Hypothetical protein Y70C5C.1 [Caenorhabditis elegans]
emb|CAB16537.2| Hypothetical protein Y70C5C.1 [Caenorhabditis elegans]
Length = 985
Score = 730 bits (1884), Expect = 0.0, Method: Composition-based stats.
Identities = 379/920 (41%), Positives = 569/920 (61%), Gaps = 5/920 (0%)
Query: 54 ITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHM 113
I K +D+REYRGLEL NGI+VLL+SDPTTDKS+AALDV++G L DP + GL+HFCEHM
Sbjct: 16 ILKGAQDEREYRGLELTNGIRVLLVSDPTTDKSAAALDVNVGHLMDPWELPGLAHFCEHM 75
Query: 114 LFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPL 173
LFLGT KYP ENEY +FL+ HAG +NA T+ +HTNY+F+V + L GALDRF QFFL P
Sbjct: 76 LFLGTAKYPSENEYFKFLTAHAGRANANTATDHTNYFFEVKPDQLPGALDRFVQFFLSPQ 135
Query: 174 FDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQE 233
F ES +REV AVDSEH N+ NDAWR Q+ ++ P H + KFGTGNK TL ++
Sbjct: 136 FTESATEREVCAVDSEHSNNLNNDAWRFLQVHRSCAKPGHDYGKFGTGNKKTLLEDARKQ 195
Query: 234 GIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKL-FSEVENKNVPLPEFPEHP 292
GI+ R LL+FH +YSSN+M C++G+ESLD L + + F+ ++NK + + E P
Sbjct: 196 GIEPRDALLQFHKKWYSSNIMTCCIIGKESLDVLESYLGTFEFAAIDNKKLERQIWKEFP 255
Query: 293 FQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKS 352
F E L + +VPIKD R + ++FP PDL + S P HY+ HLIGHEG GSLLSELK
Sbjct: 256 FGPEQLGKRIDVVPIKDTRQISISFPFPDLTGEFLSQPEHYISHLIGHEGHGSLLSELKR 315
Query: 353 KGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQ 412
GWV +L G A GF F + ++L+ EGL HV++II MF YI +++ GP++WV +
Sbjct: 316 LGWVVSLQSGYVVQAAGFGNFQVGIELSTEGLEHVDEIIQLMFNYIGMMQSSGPKQWVHE 375
Query: 413 ECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLR 472
E +L AV FRFKDKE+P S +A L P + VL++ +LL + P I+ +L L
Sbjct: 376 ELAELRAVTFRFKDKEQPMAMASCVAARLQRIPFKHVLSSPHLLTNYEPVRIKELLSMLI 435
Query: 473 PENVRVAIVSKSFEGKTDRTEE-WYGTQYKQEAIPDEVIKKWQNA--DLNGKFKLPTKNE 529
P N+++ +VS+ F+G+ T E YGT+ K I E ++K++ A + LP KN+
Sbjct: 436 PSNMKIQVVSQKFKGQEGNTNEPVYGTEIKVTRISSETMQKYEEALKTSHHALHLPEKNQ 495
Query: 530 FIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLH 589
+I T F+ P E + +P LI D S++WFKQDD++ +PK +P P
Sbjct: 496 YIATKFDQKPRELVKSDHPRLINDDEWSRVWFKQDDEYKMPKQETKLALTTPIVSQSPRM 555
Query: 590 CNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKM 649
++ L+L L DSL E +Y+A++AGL+Y+L+++ +G+ + V GY +KQ + K + +++
Sbjct: 556 TLLSRLWLRCLSDSLAEESYSAKVAGLNYELESSFFGVQMRVSGYAEKQALFSKHLTKRL 615
Query: 650 ATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTL 709
F+ID+ RF+++ ++ R L N QP+ + +Y LL+ + W+K +L + V L
Sbjct: 616 FNFKIDQTRFDVLFDSLKRDLTNHAFSQPYVLSQHYTELLVVDKEWSKQQLLAVCESVKL 675
Query: 710 PRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHA-HTKPLLPSQLVRYRE 768
++ F ++L H+E L++GN T++ + + + + D L A ++PL ++ + RE
Sbjct: 676 EDVQRFGKEMLQAFHLELLVYGNSTEKETIQLSKDLIDILKSAAPSSRPLFRNEHILRRE 735
Query: 769 VQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQ 828
+QL + ++Y+ H+ +++ YQ +Q+T +N + L +I+EP F+TLRTKE
Sbjct: 736 IQLNNGDEYIYRHLQTTHDVGCVQVTYQIGVQNTYDNAVIGLIKNLITEPAFDTLRTKES 795
Query: 829 LGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQA 888
LGYIV++ G L+ ++Q K ++ R+EAFL ++ K I +M +E F+ +
Sbjct: 796 LGYIVWTRTHFNCGTVALQILVQGPKSVDHVLERIEAFLESVRKEIVEMPQEEFENRVSG 855
Query: 889 LAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDA 948
L + +KPK LS K+W EI +QYNF R +V LKT+ KED+I + + + A
Sbjct: 856 LIAQLEEKPKTLSCRFKKFWDEIECRQYNFTRIEEDVELLKTIKKEDVIALFDKKIRKGA 915
Query: 949 PRRHKVSVHVLAREMDSCPV 968
R K++V V + D V
Sbjct: 916 AERRKLAVIVHGKSEDRAAV 935
Searching..................................................done
Results from round 2
Score E
Sequences producing significant alignments: (bits) Value
Sequences used in model and found again:
ref|XP_001501085.1| PREDICTED: similar to insulin-degrading... 1491 0.0
ref|NP_004960.2| insulysin [Homo sapiens] >gi|55959215|emb|... 1463 0.0
ref|XP_507922.2| PREDICTED: insulysin isoform 4 [Pan troglo... 1461 0.0
ref|XP_001090249.1| PREDICTED: insulysin isoform 3 [Macaca ... 1459 0.0
ref|XP_001146582.1| PREDICTED: insulysin isoform 3 [Pan tro... 1447 0.0
ref|NP_001069317.1| insulin-degrading enzyme [Bos taurus] >... 1446 0.0
sp|P14735|IDE_HUMAN Insulin-degrading enzyme (Insulysin) (I... 1435 0.0
ref|NP_112419.2| insulin degrading enzyme [Mus musculus] >g... 1422 0.0
ref|NP_037291.1| insulin degrading enzyme [Rattus norvegicu... 1416 0.0
sp|Q9JHR7|IDE_MOUSE Insulin-degrading enzyme (Insulysin) (I... 1415 0.0
ref|XP_001506502.1| PREDICTED: similar to insulin-degrading... 1411 0.0
ref|XP_534963.2| PREDICTED: similar to Insulin-degrading en... 1392 0.0
ref|XP_001146520.1| PREDICTED: insulysin isoform 2 [Pan tro... 1386 0.0
pdb|2G47|A Chain A, Crystal Structure Of Human Insulin-Degr... 1386 0.0
ref|XP_001090137.1| PREDICTED: insulysin isoform 2 [Macaca ... 1386 0.0
pdb|2JG4|A Chain A, Substrate-Free Ide Structure In Its Clo... 1386 0.0
gb|EDL41785.1| insulin degrading enzyme [Mus musculus] 1367 0.0
pdb|2WBY|A Chain A, Crystal Structure Of Human Insulin-Degr... 1364 0.0
ref|NP_001082994.1| insulin-degrading enzyme [Danio rerio] ... 1341 0.0
dbj|BAF62161.1| insulin-degrading enzyme [Danio rerio] 1341 0.0
ref|XP_001146439.1| PREDICTED: insulysin isoform 1 [Pan tro... 1179 0.0
ref|XP_001090017.1| PREDICTED: insulysin isoform 1 [Macaca ... 1178 0.0
ref|XP_001847597.1| metalloprotease [Culex pipiens quinquef... 1147 0.0
ref|XP_971897.1| PREDICTED: similar to Insulin-degrading en... 1143 0.0
ref|XP_001661876.1| metalloprotease [Aedes aegypti] >gi|108... 1140 0.0
ref|XP_001603463.1| PREDICTED: similar to metalloprotease [... 1138 0.0
ref|NP_524182.2| Insulin degrading metalloproteinase CG5517... 1102 0.0
gb|AAO74689.1| RE17458p [Drosophila melanogaster] 1102 0.0
ref|XP_001629798.1| predicted protein [Nematostella vectens... 1099 0.0
sp|P22817|IDE_DROME Insulin-degrading enzyme (Insulysin) (I... 1095 0.0
gb|AAA28439.1| insulin-degrading enzyme 1089 0.0
ref|XP_311589.4| AGAP010351-PA [Anopheles gambiae str. PEST... 1082 0.0
emb|CAO23586.1| unnamed protein product [Vitis vinifera] 1080 0.0
ref|XP_748141.1| a-pheromone processing metallopeptidase St... 1078 0.0
ref|XP_001266332.1| a-pheromone processing metallopeptidase... 1077 0.0
gb|EDP51051.1| a-pheromone processing metallopeptidase Ste2... 1077 0.0
ref|NP_181710.1| peptidase M16 family protein / insulinase ... 1075 0.0
dbj|BAE98754.1| putative zinc protease [Arabidopsis thaliana] 1074 0.0
ref|XP_001276340.1| a-pheromone processing metallopeptidase... 1074 0.0
ref|XP_001354132.1| GA18943-PA [Drosophila pseudoobscura] >... 1071 0.0
ref|NP_001060044.1| Os07g0570300 [Oryza sativa (japonica cu... 1069 0.0
gb|ABH09708.1| STE23-like protein [Penicillium marneffei] 1057 0.0
ref|XP_681313.1| hypothetical protein AN8044.2 [Aspergillus... 1054 0.0
ref|XP_001397499.1| hypothetical protein An16g01860 [Asperg... 1054 0.0
dbj|BAC79699.1| putative insulin degrading enzyme [Oryza sa... 1052 0.0
emb|CAO23585.1| unnamed protein product [Vitis vinifera] 1050 0.0
emb|CAC67408.1| insulin degrading enzyme [Solanum lycopersi... 1048 0.0
gb|EAZ04397.1| hypothetical protein OsI_025629 [Oryza sativ... 1045 0.0
gb|EAZ40359.1| hypothetical protein OsJ_023842 [Oryza sativ... 1044 0.0
gb|EEH46323.1| insulin-degrading enzyme [Paracoccidioides b... 1043 0.0
ref|NP_001044429.1| Os01g0778800 [Oryza sativa (japonica cu... 1042 0.0
ref|XP_956166.1| hypothetical protein NCU00481 [Neurospora ... 1037 0.0
ref|XP_001820380.1| hypothetical protein [Aspergillus oryza... 1035 0.0
ref|XP_759404.1| hypothetical protein UM03257.1 [Ustilago m... 1034 0.0
ref|XP_001674236.1| Hypothetical protein CBG09322 [Caenorha... 1034 0.0
ref|XP_001242515.1| hypothetical protein CIMG_06411 [Coccid... 1033 0.0
ref|XP_001770543.1| predicted protein [Physcomitrella paten... 1033 0.0
gb|EEH33611.1| A-factor-processing enzyme [Paracoccidioides... 1031 0.0
ref|XP_001543275.1| conserved hypothetical protein [Ajellom... 1030 0.0
ref|XP_001896776.1| insulin-degrading enzyme [Brugia malayi... 1020 0.0
emb|CAB66104.1| protease-like protein [Arabidopsis thaliana] 1017 0.0
gb|EDU43925.1| insulin-degrading enzyme [Pyrenophora tritic... 1016 0.0
ref|XP_387087.1| hypothetical protein FG06911.1 [Gibberella... 1016 0.0
ref|NP_741542.1| F44E7.4b [Caenorhabditis elegans] >gi|2128... 1014 0.0
ref|XP_505854.1| hypothetical protein [Yarrowia lipolytica]... 1014 0.0
ref|XP_360292.2| hypothetical protein MGG_13149 [Magnaporth... 1013 0.0
ref|XP_001218442.1| hypothetical protein ATEG_09820 [Asperg... 1012 0.0
ref|XP_001761886.1| predicted protein [Physcomitrella paten... 1012 0.0
ref|XP_001908020.1| unnamed protein product [Podospora anse... 1012 0.0
ref|XP_001590112.1| hypothetical protein SS1G_08876 [Sclero... 1011 0.0
gb|EAZ04398.1| hypothetical protein OsI_025630 [Oryza sativ... 1010 0.0
ref|XP_001801272.1| hypothetical protein SNOG_11020 [Phaeos... 1006 0.0
ref|NP_504514.2| F44E7.4c [Caenorhabditis elegans] >gi|2737... 1005 0.0
ref|NP_741543.1| F44E7.4a [Caenorhabditis elegans] >gi|2291... 1005 0.0
gb|EAY76035.1| hypothetical protein OsI_003882 [Oryza sativ... 1002 0.0
emb|CAM16904.1| nardilysin, N-arginine dibasic convertase, ... 994 0.0
ref|XP_001731164.1| hypothetical protein MGL_1347 [Malassez... 994 0.0
emb|CAA63696.1| NRD2 convertase [Rattus sp.] 993 0.0
ref|NP_507226.2| Y70C5C.1 [Caenorhabditis elegans] >gi|5808... 991 0.0
gb|AAH26832.1| Nardilysin, N-arginine dibasic convertase, N... 990 0.0
ref|NP_666262.2| nardilysin, N-arginine dibasic convertase,... 990 0.0
ref|XP_532578.2| PREDICTED: similar to nardilysin (N-argini... 989 0.0
ref|NP_037125.1| n-arginine dibasic convertase 1 [Rattus no... 988 0.0
gb|EDL90380.1| nardilysin, N-arginine dibasic convertase 1 ... 987 0.0
ref|XP_001105075.1| PREDICTED: similar to nardilysin (N-arg... 987 0.0
ref|XP_513403.2| PREDICTED: nardilysin (N-arginine dibasic ... 986 0.0
dbj|BAD52843.1| putative insulin degrading enzyme [Oryza sa... 984 0.0
ref|NP_002516.2| nardilysin (N-arginine dibasic convertase)... 984 0.0
ref|XP_859649.1| PREDICTED: similar to Nardilysin precursor... 984 0.0
ref|XP_001763915.1| predicted protein [Physcomitrella paten... 983 0.0
ref|XP_001140946.1| PREDICTED: nardilysin (N-arginine dibas... 981 0.0
ref|XP_001491380.1| PREDICTED: similar to nardilysin (N-arg... 980 0.0
sp|O43847|NRDC_HUMAN Nardilysin precursor (N-arginine dibas... 979 0.0
ref|NP_001095132.1| nardilysin (N-arginine dibasic converta... 979 0.0
gb|EDN59292.1| metalloprotease [Saccharomyces cerevisiae YJ... 978 0.0
emb|CAA63694.1| NRD2 convertase [Homo sapiens] 977 0.0
ref|XP_001491329.1| PREDICTED: similar to nardilysin (N-arg... 977 0.0
gb|EAX06804.1| nardilysin (N-arginine dibasic convertase), ... 977 0.0
ref|NP_013493.2| Metalloprotease involved, with homolog Axl... 977 0.0
gb|AAH23786.1| Nrd1 protein [Mus musculus] 976 0.0
sp|Q5R4H6|NRDC_PONPY Nardilysin precursor (N-arginine dibas... 976 0.0
ref|XP_001251166.1| PREDICTED: similar to NRD1 protein isof... 975 0.0
ref|XP_001251122.1| PREDICTED: similar to NRD1 protein isof... 975 0.0
ref|XP_588554.3| PREDICTED: similar to NRD1 protein isoform... 975 0.0
ref|XP_001251077.1| PREDICTED: similar to NRD1 protein isof... 975 0.0
ref|XP_001140731.1| PREDICTED: nardilysin (N-arginine dibas... 973 0.0
emb|CAA63698.1| NRD1 convertase [Homo sapiens] 972 0.0
ref|XP_001491299.1| PREDICTED: similar to nardilysin (N-arg... 972 0.0
gb|EAX06805.1| nardilysin (N-arginine dibasic convertase), ... 972 0.0
ref|XP_001391726.1| hypothetical protein An07g06490 [Asperg... 972 0.0
gb|EAX06808.1| nardilysin (N-arginine dibasic convertase), ... 972 0.0
gb|AAQ63406.1| nardilysin isoform [Homo sapiens] 970 0.0
ref|XP_001491355.1| PREDICTED: similar to nardilysin (N-arg... 969 0.0
ref|NP_984913.1| AER053Cp [Ashbya gossypii ATCC 10895] >gi|... 969 0.0
ref|ZP_01258854.1| peptidase, insulinase family protein [Vi... 969 0.0
ref|NP_798585.1| peptidase, insulinase family [Vibrio parah... 968 0.0
ref|NP_001023928.1| F44E7.4d [Caenorhabditis elegans] >gi|5... 965 0.0
ref|ZP_02195786.1| peptidase, insulinase family protein [Vi... 964 0.0
gb|EAZ40360.1| hypothetical protein OsJ_023843 [Oryza sativ... 962 0.0
ref|ZP_01474320.1| hypothetical protein VEx2w_02003082 [Vib... 962 0.0
ref|ZP_01987074.1| insulin-degrading enzyme [Vibrio harveyi... 960 0.0
gb|AAC39597.1| NRD convertase [Homo sapiens] 959 0.0
ref|XP_001646584.1| hypothetical protein Kpol_1055p83 [Vand... 958 0.0
ref|XP_001775609.1| predicted protein [Physcomitrella paten... 957 0.0
gb|EDN12518.1| peptidase, insulinase family [Vibrio cholera... 954 0.0
ref|XP_001140801.1| PREDICTED: nardilysin (N-arginine dibas... 954 0.0
ref|ZP_01978745.1| peptidase, insulinase family [Vibrio cho... 954 0.0
ref|NP_231704.1| peptidase, insulinase family [Vibrio chole... 953 0.0
ref|ZP_01948940.1| peptidase, insulinase family [Vibrio cho... 953 0.0
gb|EDN15048.1| peptidase, insulinase family [Vibrio cholera... 953 0.0
ref|NP_001038180.2| hypothetical protein LOC557565 [Danio r... 951 0.0
ref|ZP_01482660.1| hypothetical protein VchoR_02001413 [Vib... 951 0.0
ref|ZP_01981574.1| peptidase, insulinase family [Vibrio cho... 951 0.0
ref|ZP_01478796.1| hypothetical protein VchoM_02002058 [Vib... 951 0.0
ref|ZP_01956551.1| peptidase, insulinase family [Vibrio cho... 950 0.0
gb|EAZ49727.1| peptidase, insulinase family [Vibrio cholera... 950 0.0
ref|NP_935232.1| peptidase, insulinase family [Vibrio vulni... 949 0.0
ref|NP_760850.1| Peptidase [Vibrio vulnificus CMCP6] >gi|27... 948 0.0
ref|NP_504532.1| C02G6.1 [Caenorhabditis elegans] >gi|12801... 948 0.0
ref|ZP_01485575.1| hypothetical protein VchoV5_02001802 [Vi... 947 0.0
ref|XP_447076.1| unnamed protein product [Candida glabrata]... 945 0.0
ref|XP_001362262.1| PREDICTED: similar to nardilysin (N-arg... 945 0.0
ref|XP_001362352.1| PREDICTED: similar to nardilysin (N-arg... 943 0.0
ref|NP_001118852.1| peptidase M16 family protein / insulina... 943 0.0
ref|NP_001026455.1| nardilysin (N-arginine dibasic converta... 943 0.0
ref|YP_129176.1| putative peptidase, insulinase family [Pho... 941 0.0
ref|XP_568105.1| insulin degrading enzyme [Cryptococcus neo... 940 0.0
ref|ZP_01813161.1| peptidase, insulinase family protein [Vi... 940 0.0
ref|XP_773498.1| hypothetical protein CNBI1120 [Cryptococcu... 939 0.0
ref|XP_454175.1| unnamed protein product [Kluyveromyces lac... 937 0.0
ref|XP_694205.1| PREDICTED: similar to Nardilysin, N-argini... 936 0.0
ref|ZP_00990723.1| peptidase, insulinase family [Vibrio spl... 935 0.0
ref|ZP_01222787.1| putative peptidase, insulinase family pr... 935 0.0
ref|ZP_01064420.1| peptidase, insulinase family protein [Vi... 935 0.0
ref|YP_733547.1| Insulysin [Shewanella sp. MR-4] >gi|113884... 933 0.0
ref|YP_001366970.1| peptidase M16 domain protein [Shewanell... 933 0.0
ref|ZP_01159983.1| putative peptidase, insulinase family pr... 933 0.0
ref|ZP_01706404.1| peptidase M16-like [Shewanella putrefaci... 933 0.0
ref|YP_001183975.1| peptidase M16 domain protein [Shewanell... 932 0.0
ref|YP_737533.1| peptidase M16 domain protein [Shewanella s... 932 0.0
ref|YP_001051112.1| peptidase M16 domain protein [Shewanell... 932 0.0
ref|YP_962945.1| peptidase M16 domain protein [Shewanella s... 931 0.0
ref|YP_869105.1| peptidase M16 domain protein [Shewanella s... 931 0.0
ref|YP_001094545.1| peptidase M16 domain protein [Shewanell... 931 0.0
ref|XP_001760214.1| predicted protein [Physcomitrella paten... 931 0.0
ref|NP_718646.1| peptidase, M16 family [Shewanella oneidens... 931 0.0
ref|ZP_01235782.1| putative peptidase, insulinase family pr... 931 0.0
ref|YP_001555276.1| peptidase M16 domain protein [Shewanell... 930 0.0
ref|YP_001674877.1| peptidase M16 domain protein [Shewanell... 929 0.0
ref|ZP_01844037.1| peptidase M16 domain protein [Shewanella... 929 0.0
ref|ZP_02157408.1| peptidase, M16 family protein [Shewanell... 928 0.0
ref|ZP_01866422.1| peptidase, insulinase family protein [Vi... 927 0.0
emb|CAO77947.1| nardilysin, N-arginine dibasic convertase, ... 926 0.0
ref|YP_001446294.1| hypothetical protein VIBHAR_03118 [Vibr... 926 0.0
ref|YP_001502447.1| peptidase M16 domain protein [Shewanell... 925 0.0
ref|YP_928038.1| peptidase, M16 family [Shewanella amazonen... 924 0.0
gb|EAY76045.1| hypothetical protein OsI_003892 [Oryza sativ... 924 0.0
ref|NP_593966.1| metallopeptidase [Schizosaccharomyces pomb... 923 0.0
ref|YP_205192.1| protease III [Vibrio fischeri ES114] >gi|5... 918 0.0
ref|YP_001761387.1| peptidase M16 domain protein [Shewanell... 917 0.0
ref|YP_001141698.1| insulinase [Aeromonas salmonicida subsp... 915 0.0
ref|ZP_02135987.1| insulin-degrading enzyme [Vibrio fischer... 913 0.0
ref|YP_001473373.1| peptidase M16 domain protein [Shewanell... 910 0.0
ref|YP_856528.1| peptidase, insulinase family [Aeromonas hy... 906 0.0
ref|YP_562541.1| peptidase M16-like protein [Shewanella den... 904 0.0
gb|EAY89915.1| hypothetical protein OsI_011148 [Oryza sativ... 898 0.0
ref|NP_001050040.1| Os03g0336300 [Oryza sativa (japonica cu... 898 0.0
gb|EAZ26839.1| hypothetical protein OsJ_010322 [Oryza sativ... 897 0.0
ref|YP_436112.1| Secreted/periplasmic Zn-dependent peptidas... 895 0.0
dbj|BAF01167.1| hypothetical protein [Arabidopsis thaliana] 895 0.0
ref|NP_172173.2| metalloendopeptidase [Arabidopsis thaliana] 894 0.0
ref|XP_719241.1| a-factor pheromone maturation protease [Ca... 891 0.0
ref|XP_001874916.1| predicted protein [Laccaria bicolor S23... 886 0.0
gb|EAZ13744.1| hypothetical protein OsJ_003569 [Oryza sativ... 886 0.0
emb|CAO21314.1| unnamed protein product [Vitis vinifera] 885 0.0
ref|XP_001524140.1| conserved hypothetical protein [Loddero... 885 0.0
ref|YP_751350.1| peptidase M16 domain protein [Shewanella f... 883 0.0
ref|XP_001649937.1| metalloprotease [Aedes aegypti] >gi|108... 882 0.0
ref|YP_001007484.1| protease III precursor [Yersinia entero... 882 0.0
ref|ZP_00827012.1| COG1025: Secreted/periplasmic Zn-depende... 878 0.0
ref|XP_001383768.2| hypothetical protein PICST_56651 [Pichi... 878 0.0
ref|XP_456547.1| hypothetical protein DEHA0A05214g [Debaryo... 877 0.0
ref|ZP_01101893.1| protease III precursor [gamma proteobact... 876 0.0
ref|ZP_00830096.1| COG1025: Secreted/periplasmic Zn-depende... 872 0.0
ref|ZP_00822919.1| COG1025: Secreted/periplasmic Zn-depende... 871 0.0
ref|XP_001623609.1| predicted protein [Nematostella vectens... 870 0.0
ref|YP_001719796.1| peptidase M16 domain protein [Yersinia ... 869 0.0
ref|ZP_00834380.1| COG1025: Secreted/periplasmic Zn-depende... 868 0.0
ref|NP_404633.1| protease III precursor [Yersinia pestis CO... 866 0.0
ref|ZP_03838288.1| hypothetical protein CATC2_19978 [Citrob... 861 0.0
ref|YP_001480039.1| peptidase M16 domain protein [Serratia ... 859 0.0
ref|XP_001833053.1| hypothetical protein CC1G_01115 [Coprin... 859 0.0
ref|ZP_02644586.1| protease III [Salmonella enterica subsp.... 858 0.0
ref|XP_001486793.1| hypothetical protein PGUG_00170 [Pichia... 857 0.0
ref|NP_461912.1| protease III [Salmonella typhimurium LT2] ... 857 0.0
ref|ZP_02683828.1| protease III [Salmonella enterica subsp.... 856 0.0
ref|YP_311808.1| protease III [Shigella sonnei Ss046] >gi|7... 856 0.0
ref|YP_217920.1| protease III [Salmonella enterica subsp. e... 855 0.0
ref|ZP_02667694.1| protease III [Salmonella enterica subsp.... 855 0.0
ref|NP_755290.1| Protease III precursor [Escherichia coli C... 854 0.0
ref|ZP_02343890.1| protease III [Salmonella enterica subsp.... 854 0.0
ref|XP_001695185.1| insulinase-like metalloprotease [Chlamy... 854 0.0
ref|ZP_00713497.1| COG1025: Secreted/periplasmic Zn-depende... 854 0.0
ref|ZP_03833747.1| protease III precursor [Pectobacterium c... 854 0.0
ref|YP_001744989.1| protease III [Escherichia coli SMS-3-5]... 854 0.0
ref|ZP_02651766.1| protease III precursor [Salmonella enter... 854 0.0
ref|ZP_00714851.1| COG1025: Secreted/periplasmic Zn-depende... 854 0.0
ref|YP_001573574.1| hypothetical protein SARI_04665 [Salmon... 854 0.0
ref|ZP_02704095.1| protease III [Salmonella enterica subsp.... 854 0.0
ref|YP_049101.1| protease III precursor [Erwinia carotovora... 854 0.0
ref|YP_001464156.1| protease III [Escherichia coli E24377A]... 853 0.0
ref|ZP_00923440.1| COG1025: Secreted/periplasmic Zn-depende... 853 0.0
ref|NP_708612.1| protease III [Shigella flexneri 2a str. 30... 853 0.0
ref|ZP_02349797.1| protease III precursor [Salmonella enter... 853 0.0
ref|ZP_00712570.1| COG1025: Secreted/periplasmic Zn-depende... 853 0.0
ref|NP_417298.1| protease III [Escherichia coli str. K-12 s... 853 0.0
ref|ZP_00920643.1| COG1025: Secreted/periplasmic Zn-depende... 852 0.0
ref|YP_542202.1| protease III precursor [Escherichia coli U... 852 0.0
ref|ZP_02560586.1| protease III [Salmonella enterica subsp.... 852 0.0
ref|ZP_02832280.1| protease III [Salmonella enterica subsp.... 852 0.0
pdb|1Q2L|A Chain A, Crystal Structure Of Pitrilysin 852 0.0
gb|AAB40468.1| protease III precursor (pitrilysin) 852 0.0
ref|ZP_02999194.1| protease III [Escherichia coli 53638] >g... 852 0.0
ref|NP_311705.1| protease III [Escherichia coli O157:H7 str... 852 0.0
ref|ZP_02568654.1| protease III [Salmonella enterica subsp.... 851 0.0
ref|YP_002807041.1| protease III [Escherichia sp. 1_1_43] >... 851 0.0
ref|YP_001881438.1| protease III [Shigella boydii CDC 3083-... 851 0.0
ref|ZP_02697767.1| protease III [Salmonella enterica subsp.... 851 0.0
ref|YP_409069.1| protease III [Shigella boydii Sb227] >gi|8... 851 0.0
ref|YP_001177979.1| peptidase M16 domain protein [Enterobac... 850 0.0
ref|YP_959771.1| peptidase M16 domain protein [Marinobacter... 849 0.0
ref|ZP_01892098.1| Secreted/periplasmic Zn-dependent peptid... 849 0.0
ref|YP_404546.1| protease III [Shigella dysenteriae Sd197] ... 848 0.0
ref|NP_289373.1| protease III [Escherichia coli O157:H7 EDL... 848 0.0
ref|NP_457388.1| protease III precursor (pitrilysin) [Salmo... 848 0.0
ref|ZP_02900475.1| protease III [Escherichia albertii TW076... 847 0.0
ref|XP_396981.2| PREDICTED: similar to Insulin-degrading en... 847 0.0
gb|EEH94306.1| protease III [Citrobacter sp. 30_2] 846 0.0
ref|YP_001455683.1| hypothetical protein CKO_04186 [Citroba... 846 0.0
ref|NP_001044431.1| Os01g0779100 [Oryza sativa (japonica cu... 845 0.0
gb|AAF63132.1|AC011001_2 Putative N-arginine dibasic conver... 844 0.0
ref|YP_268860.1| zinc metallopeptidase, M16 family [Colwell... 844 0.0
ref|ZP_01616823.1| Secreted/periplasmic Zn-dependent peptid... 843 0.0
ref|YP_001589894.1| hypothetical protein SPAB_03726 [Salmon... 842 0.0
ref|ZP_01896589.1| putative peptidase, insulinase family [M... 842 0.0
ref|YP_152017.1| protease III precursor (pitrilysin) [Salmo... 842 0.0
ref|XP_001194830.1| PREDICTED: similar to Insulin-degrading... 841 0.0
ref|YP_001336858.1| protease III [Klebsiella pneumoniae sub... 840 0.0
ref|ZP_02679542.1| protease III [Salmonella enterica subsp.... 839 0.0
ref|XP_001599332.1| PREDICTED: similar to metalloendopeptid... 836 0.0
ref|NP_567049.2| peptidase M16 family protein / insulinase ... 836 0.0
ref|XP_795975.2| PREDICTED: similar to Insulin-degrading en... 835 0.0
ref|ZP_03829109.1| protease III precursor [Pectobacterium c... 835 0.0
ref|ZP_01736964.1| Secreted/periplasmic Zn-dependent peptid... 834 0.0
ref|ZP_01135442.1| zinc metallopeptidase, M16 family protei... 827 0.0
ref|YP_001908664.1| Protease 3 precursor (Pitrilysin) [Erwi... 824 0.0
ref|YP_001436619.1| hypothetical protein ESA_00488 [Enterob... 824 0.0
ref|XP_001434792.1| hypothetical protein GSPATT00006701001 ... 823 0.0
ref|YP_339493.1| peptidase [Pseudoalteromonas haloplanktis ... 816 0.0
ref|XP_001031077.1| Insulysin, Insulin-degrading enzyme [Te... 810 0.0
ref|NP_927976.1| Protease III precursor (pitrilysin) [Photo... 810 0.0
ref|ZP_01613408.1| protease III [Alteromonadales bacterium ... 809 0.0
dbj|BAD92441.1| insulysin variant [Homo sapiens] 809 0.0
emb|CAL51499.1| peptidase M16 family protein / insulinase f... 809 0.0
ref|NP_504531.2| C02G6.2 [Caenorhabditis elegans] >gi|33620... 805 0.0
ref|XP_966800.1| PREDICTED: similar to Nardilysin precursor... 804 0.0
ref|ZP_01168295.1| zinc metallopeptidase, M16 family [Ocean... 800 0.0
ref|ZP_01223918.1| peptidase, insulinase family protein [ma... 799 0.0
ref|YP_269852.1| zinc metallopeptidase, M16 family [Colwell... 798 0.0
ref|XP_001449286.1| hypothetical protein GSPATT00016702001 ... 798 0.0
ref|ZP_01307403.1| Secreted/periplasmic Zn-dependent peptid... 797 0.0
ref|ZP_02959293.1| hypothetical protein PROSTU_01129 [Provi... 796 0.0
ref|NP_649271.1| CG10588 CG10588-PA [Drosophila melanogaste... 794 0.0
gb|EAW50092.1| insulin-degrading enzyme, isoform CRA_b [Hom... 792 0.0
ref|XP_624437.2| PREDICTED: similar to Nardilysin precursor... 791 0.0
ref|ZP_01114527.1| Secreted/periplasmic Zn-dependent peptid... 791 0.0
ref|XP_001660612.1| metalloendopeptidase [Aedes aegypti] >g... 790 0.0
ref|YP_455654.1| protease III precursor [Sodalis glossinidi... 786 0.0
ref|NP_495575.2| C28F5.4 [Caenorhabditis elegans] >gi|15038... 785 0.0
ref|XP_001024628.2| Insulysin, Insulin-degrading enzyme [Te... 780 0.0
Sequences not found previously or not previously below threshold:
>ref|XP_001501085.1| PREDICTED: similar to insulin-degrading enzyme [Equus caballus]
Length = 1212
Score = 1491 bits (3860), Expect = 0.0, Method: Composition-based stats.
Identities = 1005/1019 (98%), Positives = 1012/1019 (99%)
Query: 1 MRYRLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED 60
MRYRLAWLLHPALPSTFRS LGARLPPPERL GFQKKTYSKMNNPAIKR+GNHI KSPED
Sbjct: 194 MRYRLAWLLHPALPSTFRSALGARLPPPERLSGFQKKTYSKMNNPAIKRLGNHIIKSPED 253
Query: 61 KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK 120
KREYRGL+LANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK
Sbjct: 254 KREYRGLQLANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK 313
Query: 121 YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD 180
YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD
Sbjct: 314 YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD 373
Query: 181 REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE 240
REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE
Sbjct: 374 REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE 433
Query: 241 LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ 300
LLKFHS YYSSNLMA+CVLGRESLDDLT+LVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ
Sbjct: 434 LLKFHSTYYSSNLMAICVLGRESLDDLTDLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ 493
Query: 301 LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV 360
LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV
Sbjct: 494 LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV 553
Query: 361 GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 420
GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV
Sbjct: 554 GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 613
Query: 421 AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI 480
AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVA+
Sbjct: 614 AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAV 673
Query: 481 VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL 540
VSKSFEGKTD TEEWYGTQY+QEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEIL L
Sbjct: 674 VSKSFEGKTDCTEEWYGTQYRQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILSL 733
Query: 541 EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL 600
EKEATPYP+LIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL
Sbjct: 734 EKEATPYPSLIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL 793
Query: 601 KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE 660
KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE
Sbjct: 794 KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE 853
Query: 661 IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 720
IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL
Sbjct: 854 IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 913
Query: 721 SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 780
SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ
Sbjct: 914 SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 973
Query: 781 QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 840
QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA
Sbjct: 974 QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 1033
Query: 841 NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL 900
NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL
Sbjct: 1034 NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL 1093
Query: 901 SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA 960
SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA
Sbjct: 1094 SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA 1153
Query: 961 REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL 1019
REMDSCPVVGEFPCQNDINLSQAP LPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL
Sbjct: 1154 REMDSCPVVGEFPCQNDINLSQAPGLPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL 1212
>ref|NP_004960.2| insulysin [Homo sapiens]
emb|CAI13670.1| insulin-degrading enzyme [Homo sapiens]
gb|AAH96337.1| Insulin-degrading enzyme [Homo sapiens]
gb|AAH96339.1| Insulin-degrading enzyme [Homo sapiens]
gb|AAH96336.1| Insulin-degrading enzyme [Homo sapiens]
gb|EAW50090.1| insulin-degrading enzyme, isoform CRA_a [Homo sapiens]
gb|EAW50091.1| insulin-degrading enzyme, isoform CRA_a [Homo sapiens]
Length = 1019
Score = 1463 bits (3787), Expect = 0.0, Method: Composition-based stats.
Identities = 1019/1019 (100%), Positives = 1019/1019 (100%)
Query: 1 MRYRLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED 60
MRYRLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED
Sbjct: 1 MRYRLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED 60
Query: 61 KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK 120
KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK
Sbjct: 61 KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK 120
Query: 121 YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD 180
YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD
Sbjct: 121 YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD 180
Query: 181 REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE 240
REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE
Sbjct: 181 REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE 240
Query: 241 LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ 300
LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ
Sbjct: 241 LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ 300
Query: 301 LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV 360
LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV
Sbjct: 301 LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV 360
Query: 361 GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 420
GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV
Sbjct: 361 GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 420
Query: 421 AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI 480
AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI
Sbjct: 421 AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI 480
Query: 481 VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL 540
VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL
Sbjct: 481 VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL 540
Query: 541 EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL 600
EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL
Sbjct: 541 EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL 600
Query: 601 KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE 660
KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE
Sbjct: 601 KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE 660
Query: 661 IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 720
IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL
Sbjct: 661 IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 720
Query: 721 SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 780
SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ
Sbjct: 721 SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 780
Query: 781 QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 840
QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA
Sbjct: 781 QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 840
Query: 841 NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL 900
NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL
Sbjct: 841 NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL 900
Query: 901 SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA 960
SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA
Sbjct: 901 SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA 960
Query: 961 REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL 1019
REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL
Sbjct: 961 REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL 1019
>ref|XP_507922.2| PREDICTED: insulysin isoform 4 [Pan troglodytes]
Length = 1019
Score = 1461 bits (3783), Expect = 0.0, Method: Composition-based stats.
Identities = 1018/1019 (99%), Positives = 1018/1019 (99%)
Query: 1 MRYRLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED 60
MRYRLAWLLHPAL STFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED
Sbjct: 1 MRYRLAWLLHPALSSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED 60
Query: 61 KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK 120
KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK
Sbjct: 61 KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK 120
Query: 121 YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD 180
YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD
Sbjct: 121 YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD 180
Query: 181 REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE 240
REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE
Sbjct: 181 REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE 240
Query: 241 LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ 300
LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ
Sbjct: 241 LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ 300
Query: 301 LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV 360
LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV
Sbjct: 301 LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV 360
Query: 361 GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 420
GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV
Sbjct: 361 GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 420
Query: 421 AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI 480
AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI
Sbjct: 421 AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI 480
Query: 481 VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL 540
VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL
Sbjct: 481 VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL 540
Query: 541 EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL 600
EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL
Sbjct: 541 EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL 600
Query: 601 KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE 660
KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE
Sbjct: 601 KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE 660
Query: 661 IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 720
IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL
Sbjct: 661 IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 720
Query: 721 SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 780
SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ
Sbjct: 721 SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 780
Query: 781 QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 840
QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA
Sbjct: 781 QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 840
Query: 841 NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL 900
NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL
Sbjct: 841 NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL 900
Query: 901 SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA 960
SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA
Sbjct: 901 SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA 960
Query: 961 REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL 1019
REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL
Sbjct: 961 REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL 1019
>ref|XP_001090249.1| PREDICTED: insulysin isoform 3 [Macaca mulatta]
Length = 1019
Score = 1459 bits (3777), Expect = 0.0, Method: Composition-based stats.
Identities = 1013/1019 (99%), Positives = 1016/1019 (99%)
Query: 1 MRYRLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED 60
MRYRLAWL HPALPSTFRSV GARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED
Sbjct: 1 MRYRLAWLRHPALPSTFRSVFGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED 60
Query: 61 KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK 120
KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK
Sbjct: 61 KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK 120
Query: 121 YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD 180
YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD
Sbjct: 121 YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD 180
Query: 181 REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE 240
REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE
Sbjct: 181 REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE 240
Query: 241 LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ 300
LLKFHS YYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENK+VPLPEFPEHPFQEEHLKQ
Sbjct: 241 LLKFHSTYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKSVPLPEFPEHPFQEEHLKQ 300
Query: 301 LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV 360
LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV
Sbjct: 301 LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV 360
Query: 361 GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 420
GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV
Sbjct: 361 GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 420
Query: 421 AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI 480
AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVA+
Sbjct: 421 AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAV 480
Query: 481 VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL 540
VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL
Sbjct: 481 VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL 540
Query: 541 EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL 600
EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL
Sbjct: 541 EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL 600
Query: 601 KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE 660
KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE
Sbjct: 601 KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE 660
Query: 661 IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 720
IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL
Sbjct: 661 IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 720
Query: 721 SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 780
SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ
Sbjct: 721 SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 780
Query: 781 QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 840
QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA
Sbjct: 781 QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 840
Query: 841 NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL 900
NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL
Sbjct: 841 NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL 900
Query: 901 SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA 960
SAECAKYWGEIISQQY+FDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA
Sbjct: 901 SAECAKYWGEIISQQYHFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA 960
Query: 961 REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL 1019
REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL
Sbjct: 961 REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL 1019
>ref|XP_001146582.1| PREDICTED: insulysin isoform 3 [Pan troglodytes]
Length = 1019
Score = 1447 bits (3747), Expect = 0.0, Method: Composition-based stats.
Identities = 995/1019 (97%), Positives = 1003/1019 (98%)
Query: 1 MRYRLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED 60
MRYRLAWLLHPAL STFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED
Sbjct: 1 MRYRLAWLLHPALSSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED 60
Query: 61 KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK 120
KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK
Sbjct: 61 KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK 120
Query: 121 YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD 180
YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD
Sbjct: 121 YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD 180
Query: 181 REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE 240
REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE
Sbjct: 181 REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE 240
Query: 241 LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ 300
LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ
Sbjct: 241 LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ 300
Query: 301 LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV 360
LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV
Sbjct: 301 LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV 360
Query: 361 GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 420
GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV
Sbjct: 361 GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 420
Query: 421 AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI 480
AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI
Sbjct: 421 AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI 480
Query: 481 VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL 540
VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL
Sbjct: 481 VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL 540
Query: 541 EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL 600
EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFS + Y DPLHCNM YL++ LL
Sbjct: 541 EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSRYIYADPLHCNMTYLFIRLL 600
Query: 601 KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE 660
KD L EY YAA L+GLSY + + + + LSVKGYNDKQPILLKKIIEKMATFEIDEKRFE
Sbjct: 601 KDDLKEYTYAARLSGLSYGIASGMNAILLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE 660
Query: 661 IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 720
IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL
Sbjct: 661 IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 720
Query: 721 SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 780
SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ
Sbjct: 721 SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 780
Query: 781 QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 840
QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA
Sbjct: 781 QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 840
Query: 841 NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL 900
NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL
Sbjct: 841 NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL 900
Query: 901 SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA 960
SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA
Sbjct: 901 SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA 960
Query: 961 REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL 1019
REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL
Sbjct: 961 REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL 1019
>ref|NP_001069317.1| insulin-degrading enzyme [Bos taurus]
sp|Q24K02|IDE_BOVIN Insulin-degrading enzyme (Insulysin) (Insulinase) (Insulin protease)
gb|AAI14106.1| Similar to Insulin-degrading enzyme (Insulysin) (Insulinase) (Insulin
protease) [Bos taurus]
Length = 1019
Score = 1446 bits (3745), Expect = 0.0, Method: Composition-based stats.
Identities = 1007/1019 (98%), Positives = 1011/1019 (99%)
Query: 1 MRYRLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED 60
MRYRLAWLLH ALPSTFRSVLGARLPP ERLCGFQKKTYSKMNNPAIKRIG+HI KS ED
Sbjct: 1 MRYRLAWLLHSALPSTFRSVLGARLPPSERLCGFQKKTYSKMNNPAIKRIGHHIIKSHED 60
Query: 61 KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK 120
KREYRGLELANGIKVLL+SDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK
Sbjct: 61 KREYRGLELANGIKVLLVSDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK 120
Query: 121 YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD 180
YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD
Sbjct: 121 YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD 180
Query: 181 REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE 240
REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE
Sbjct: 181 REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE 240
Query: 241 LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ 300
LLKFHS YYSSNLMA+CVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ
Sbjct: 241 LLKFHSTYYSSNLMAICVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ 300
Query: 301 LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV 360
LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV
Sbjct: 301 LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV 360
Query: 361 GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 420
GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV
Sbjct: 361 GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 420
Query: 421 AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI 480
AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI
Sbjct: 421 AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI 480
Query: 481 VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL 540
VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLP KNEFIPTNFEIL L
Sbjct: 481 VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPMKNEFIPTNFEILSL 540
Query: 541 EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL 600
EKEATPYP+LIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL
Sbjct: 541 EKEATPYPSLIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL 600
Query: 601 KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE 660
KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE
Sbjct: 601 KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE 660
Query: 661 IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 720
IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL
Sbjct: 661 IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 720
Query: 721 SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 780
SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ
Sbjct: 721 SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 780
Query: 781 QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 840
QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA
Sbjct: 781 QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 840
Query: 841 NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL 900
NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL
Sbjct: 841 NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL 900
Query: 901 SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA 960
SAECAKYWGEIISQQYNFDRDN EVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA
Sbjct: 901 SAECAKYWGEIISQQYNFDRDNIEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA 960
Query: 961 REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL 1019
REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL
Sbjct: 961 REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL 1019
>sp|P14735|IDE_HUMAN Insulin-degrading enzyme (Insulysin) (Insulinase) (Insulin protease)
gb|AAA52712.1| insulin-degrading enzyme
Length = 1019
Score = 1435 bits (3716), Expect = 0.0, Method: Composition-based stats.
Identities = 1013/1019 (99%), Positives = 1014/1019 (99%)
Query: 1 MRYRLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED 60
MRYRLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED
Sbjct: 1 MRYRLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED 60
Query: 61 KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK 120
KREYRGLELANGIKVLL+SDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK
Sbjct: 61 KREYRGLELANGIKVLLMSDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK 120
Query: 121 YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD 180
YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD
Sbjct: 121 YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD 180
Query: 181 REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE 240
REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE
Sbjct: 181 REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE 240
Query: 241 LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ 300
LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ
Sbjct: 241 LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ 300
Query: 301 LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV 360
LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV
Sbjct: 301 LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV 360
Query: 361 GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 420
GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV
Sbjct: 361 GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 420
Query: 421 AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI 480
AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI
Sbjct: 421 AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI 480
Query: 481 VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL 540
VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL
Sbjct: 481 VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL 540
Query: 541 EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL 600
EKEATPYPALIKDT MSKLWFKQDDK PKACLNFEFFSPFAYVDPLHCNMAYLYLELL
Sbjct: 541 EKEATPYPALIKDTVMSKLWFKQDDKKKKPKACLNFEFFSPFAYVDPLHCNMAYLYLELL 600
Query: 601 KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE 660
KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE
Sbjct: 601 KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE 660
Query: 661 IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 720
IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL
Sbjct: 661 IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 720
Query: 721 SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 780
SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ
Sbjct: 721 SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 780
Query: 781 QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 840
QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA
Sbjct: 781 QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 840
Query: 841 NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL 900
NGIQ LRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL
Sbjct: 841 NGIQSLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL 900
Query: 901 SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA 960
SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA
Sbjct: 901 SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA 960
Query: 961 REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL 1019
REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL
Sbjct: 961 REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL 1019
>ref|NP_112419.2| insulin degrading enzyme [Mus musculus]
gb|AAH41675.1| Insulin degrading enzyme [Mus musculus]
Length = 1019
Score = 1422 bits (3682), Expect = 0.0, Method: Composition-based stats.
Identities = 970/1019 (95%), Positives = 995/1019 (97%)
Query: 1 MRYRLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED 60
MR L WLLHPALP T RS+LGAR PP +RLCGF K+TYS M+NPAI+RI + I KSPED
Sbjct: 1 MRNGLVWLLHPALPGTLRSILGARPPPAKRLCGFPKQTYSTMSNPAIQRIEDQIVKSPED 60
Query: 61 KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK 120
KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNI GLSHFCEHMLFLGTKK
Sbjct: 61 KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIPGLSHFCEHMLFLGTKK 120
Query: 121 YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD 180
YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFD SCKD
Sbjct: 121 YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDASCKD 180
Query: 181 REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE 240
REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVR+E
Sbjct: 181 REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVREE 240
Query: 241 LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ 300
LLKFHS YYSSNLMA+CVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHL+Q
Sbjct: 241 LLKFHSTYYSSNLMAICVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLRQ 300
Query: 301 LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV 360
LYKIVPIKDIRNLYVTFPIPDLQ+YYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV
Sbjct: 301 LYKIVPIKDIRNLYVTFPIPDLQQYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV 360
Query: 361 GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 420
GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV
Sbjct: 361 GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 420
Query: 421 AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI 480
AFRFKDKERPRGYTSKIAG LHYYPL VLTAEYLLEEFRPDLI+MVLDKLRPENVRVAI
Sbjct: 421 AFRFKDKERPRGYTSKIAGKLHYYPLNGVLTAEYLLEEFRPDLIDMVLDKLRPENVRVAI 480
Query: 481 VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL 540
VSKSFEGKTDRTE+WYGTQYKQEAIP+++I+KWQNADLNGKFKLPTKNEFIPTNFEIL L
Sbjct: 481 VSKSFEGKTDRTEQWYGTQYKQEAIPEDIIQKWQNADLNGKFKLPTKNEFIPTNFEILSL 540
Query: 541 EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL 600
EK+ATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL
Sbjct: 541 EKDATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL 600
Query: 601 KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE 660
KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKI EKMATFEID+KRFE
Sbjct: 601 KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKITEKMATFEIDKKRFE 660
Query: 661 IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 720
IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL
Sbjct: 661 IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 720
Query: 721 SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 780
SRLHIEALLHGNITKQAALG+MQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ
Sbjct: 721 SRLHIEALLHGNITKQAALGVMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 780
Query: 781 QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 840
QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA
Sbjct: 781 QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 840
Query: 841 NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL 900
NGIQGLRFIIQSEKPPHYLESRVEAFLITMEK+IEDMTEEAFQKHIQALAIRRLDKPKKL
Sbjct: 841 NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKAIEDMTEEAFQKHIQALAIRRLDKPKKL 900
Query: 901 SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA 960
SAECAKYWGEIISQQYN+DRDN EVAYLKTLTK+DII+FY+EMLAVDAPRRHKVSVHVLA
Sbjct: 901 SAECAKYWGEIISQQYNYDRDNIEVAYLKTLTKDDIIRFYQEMLAVDAPRRHKVSVHVLA 960
Query: 961 REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL 1019
REMDSCPVVGEFP QNDINLS+AP LPQPEVI NMTEFKRGLPLFPLVKPHINFMAAKL
Sbjct: 961 REMDSCPVVGEFPSQNDINLSEAPPLPQPEVIHNMTEFKRGLPLFPLVKPHINFMAAKL 1019
>ref|NP_037291.1| insulin degrading enzyme [Rattus norvegicus]
sp|P35559|IDE_RAT Insulin-degrading enzyme (Insulysin) (Insulinase) (Insulin protease)
emb|CAA47689.1| insulin-degrading enzyme [Rattus norvegicus]
gb|EDM13196.1| insulin degrading enzyme [Rattus norvegicus]
Length = 1019
Score = 1416 bits (3667), Expect = 0.0, Method: Composition-based stats.
Identities = 973/1019 (95%), Positives = 995/1019 (97%)
Query: 1 MRYRLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED 60
MR L WLLHPALPST S+LGAR PP +RLCGF K+ YS MNNPAI+RI +HI KSPED
Sbjct: 1 MRNGLVWLLHPALPSTLHSILGARPPPVKRLCGFPKQIYSTMNNPAIQRIEDHIVKSPED 60
Query: 61 KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK 120
KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNI GLSHFCEHMLFLGTKK
Sbjct: 61 KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIPGLSHFCEHMLFLGTKK 120
Query: 121 YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD 180
YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFD SCKD
Sbjct: 121 YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDASCKD 180
Query: 181 REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE 240
REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVR+E
Sbjct: 181 REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVREE 240
Query: 241 LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ 300
LLKFHS YYSSNLMA+CVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ
Sbjct: 241 LLKFHSTYYSSNLMAICVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ 300
Query: 301 LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV 360
LYKIVPIKDIRNLYVTFPIPDLQ+YYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV
Sbjct: 301 LYKIVPIKDIRNLYVTFPIPDLQQYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV 360
Query: 361 GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 420
GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV
Sbjct: 361 GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 420
Query: 421 AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI 480
AFRFKDKERPRGYTSKIAG LHYYPL VLTAEYLLEEFRPDLI+MVLDKLRPENVRVAI
Sbjct: 421 AFRFKDKERPRGYTSKIAGKLHYYPLNGVLTAEYLLEEFRPDLIDMVLDKLRPENVRVAI 480
Query: 481 VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL 540
VSKSFEGKTDRTE+WYGTQYKQEAIP++VI+KWQNADLNGKFKLPTKNEFIPTNFEIL L
Sbjct: 481 VSKSFEGKTDRTEQWYGTQYKQEAIPEDVIQKWQNADLNGKFKLPTKNEFIPTNFEILAL 540
Query: 541 EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL 600
EK+ATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL
Sbjct: 541 EKDATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL 600
Query: 601 KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE 660
KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKI EKMATFEID+KRFE
Sbjct: 601 KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKITEKMATFEIDKKRFE 660
Query: 661 IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 720
IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL
Sbjct: 661 IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 720
Query: 721 SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 780
SRLHIEALLHGNITKQAALG+MQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ
Sbjct: 721 SRLHIEALLHGNITKQAALGVMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 780
Query: 781 QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 840
+RNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA
Sbjct: 781 RRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 840
Query: 841 NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL 900
NGIQGLRFIIQSEKPPHYLESRVEAFLITMEK+IEDMTEEAFQKHIQALAIRRLDKPKKL
Sbjct: 841 NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKAIEDMTEEAFQKHIQALAIRRLDKPKKL 900
Query: 901 SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA 960
SAECAKYWGEIISQQYN+DRDN EVAYLKTL+K+DIIKFYKEMLAVDAPRRHKVSVHVLA
Sbjct: 901 SAECAKYWGEIISQQYNYDRDNIEVAYLKTLSKDDIIKFYKEMLAVDAPRRHKVSVHVLA 960
Query: 961 REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL 1019
REMDSCPVVGEFP QNDINLS+AP LPQPEVI NMTEFKRGLPLFPLVKPHINFMAAKL
Sbjct: 961 REMDSCPVVGEFPSQNDINLSEAPPLPQPEVIHNMTEFKRGLPLFPLVKPHINFMAAKL 1019
>sp|Q9JHR7|IDE_MOUSE Insulin-degrading enzyme (Insulysin) (Insulinase) (Insulin protease)
emb|CAC01233.1| insulin degrading enzyme [Mus musculus]
Length = 1019
Score = 1415 bits (3664), Expect = 0.0, Method: Composition-based stats.
Identities = 968/1019 (94%), Positives = 993/1019 (97%)
Query: 1 MRYRLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED 60
MR L WLLHPALP T RS+LGAR PP +RLCGF K+TYS M+NPAI+RI + I KSPED
Sbjct: 1 MRNGLVWLLHPALPGTLRSILGARPPPAKRLCGFPKQTYSTMSNPAIQRIEDQIVKSPED 60
Query: 61 KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK 120
KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNI GLSHFCEHMLFLGTKK
Sbjct: 61 KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIPGLSHFCEHMLFLGTKK 120
Query: 121 YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD 180
YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPL D SCKD
Sbjct: 121 YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLLDASCKD 180
Query: 181 REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE 240
REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVR+E
Sbjct: 181 REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVREE 240
Query: 241 LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ 300
LLKFHS YYSSNLMA+CVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHL+Q
Sbjct: 241 LLKFHSTYYSSNLMAICVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLRQ 300
Query: 301 LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV 360
LYKIVPIKDIRNLYVTFPIPDLQ+YYKSNPG+YLGHLIGHEGPGSLLSELKSKGWVNTLV
Sbjct: 301 LYKIVPIKDIRNLYVTFPIPDLQQYYKSNPGYYLGHLIGHEGPGSLLSELKSKGWVNTLV 360
Query: 361 GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 420
GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV
Sbjct: 361 GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 420
Query: 421 AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI 480
AFRFKDKERPRGYTSKIAG LHYYPL VLTAEYLLEEFRPDLI+MVLDKLRPENVRVAI
Sbjct: 421 AFRFKDKERPRGYTSKIAGKLHYYPLNGVLTAEYLLEEFRPDLIDMVLDKLRPENVRVAI 480
Query: 481 VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL 540
VSKSFEGKTDRTE+WYGTQYKQEAIP++VI+KWQNADLNGKFKLPTKNEFIPTNFEIL L
Sbjct: 481 VSKSFEGKTDRTEQWYGTQYKQEAIPEDVIQKWQNADLNGKFKLPTKNEFIPTNFEILSL 540
Query: 541 EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL 600
EK+ATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL
Sbjct: 541 EKDATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL 600
Query: 601 KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE 660
KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVK YNDKQPILLKKI EKMATFEID+KRFE
Sbjct: 601 KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKRYNDKQPILLKKITEKMATFEIDKKRFE 660
Query: 661 IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 720
IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL
Sbjct: 661 IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 720
Query: 721 SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 780
SRLHIEALLHGNITKQAALG+MQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ
Sbjct: 721 SRLHIEALLHGNITKQAALGVMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 780
Query: 781 QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 840
QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA
Sbjct: 781 QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 840
Query: 841 NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL 900
NGIQGLRFIIQSEKPPHYLESRVEAFLITMEK+IEDMTEEAFQKHIQALAIRRLDKPKKL
Sbjct: 841 NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKAIEDMTEEAFQKHIQALAIRRLDKPKKL 900
Query: 901 SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA 960
SAECAKYWGEIISQQYN+DRDN EVAYLKTLTK+DII+FY+EMLAVDAPRRHKVSVHVLA
Sbjct: 901 SAECAKYWGEIISQQYNYDRDNIEVAYLKTLTKDDIIRFYQEMLAVDAPRRHKVSVHVLA 960
Query: 961 REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL 1019
REMDSCPVVGEFP QNDINLS+AP LPQPEVI NMTEFKRGLPLFPLVKPHINFMAAKL
Sbjct: 961 REMDSCPVVGEFPSQNDINLSEAPPLPQPEVIHNMTEFKRGLPLFPLVKPHINFMAAKL 1019
>ref|XP_001506502.1| PREDICTED: similar to insulin-degrading enzyme [Ornithorhynchus
anatinus]
Length = 1301
Score = 1411 bits (3653), Expect = 0.0, Method: Composition-based stats.
Identities = 945/1017 (92%), Positives = 973/1017 (95%), Gaps = 3/1017 (0%)
Query: 4 RLAWLLHPALPSTFRSVLGARLPPPERLCG-FQKKTYSKMNNPAIKRIGNHITKSPEDKR 62
R A+ FRS+ R R FQ+ +Y KM++ A+KRI N+I KSPEDKR
Sbjct: 287 RAPLTAVGAV--AFRSLSQTRPVANARSSFSFQRYSYGKMDHSAVKRIVNNIIKSPEDKR 344
Query: 63 EYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKKYP 122
EYRGLELANGIK +LISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKKYP
Sbjct: 345 EYRGLELANGIKAILISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKKYP 404
Query: 123 KENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKDRE 182
KENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKDRE
Sbjct: 405 KENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKDRE 464
Query: 183 VNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQELL 242
VNAVDSEHEKNVMNDAWRLFQLEKATGNP HPFSKFGTGNKYTLETRP +EGIDVRQELL
Sbjct: 465 VNAVDSEHEKNVMNDAWRLFQLEKATGNPNHPFSKFGTGNKYTLETRPTKEGIDVRQELL 524
Query: 243 KFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQLY 302
KFHS YYSSNLMA+CVLGRESLD+LT+LVVKLFSEVENKNVPLPEFPEHPFQE HL+Q+Y
Sbjct: 525 KFHSTYYSSNLMAICVLGRESLDELTSLVVKLFSEVENKNVPLPEFPEHPFQEHHLRQIY 584
Query: 303 KIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLVGG 362
K+VPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELK+KGWVNTLVGG
Sbjct: 585 KVVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKAKGWVNTLVGG 644
Query: 363 QKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAVAF 422
QKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLR EGPQEWVFQECKDLNAVAF
Sbjct: 645 QKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRTEGPQEWVFQECKDLNAVAF 704
Query: 423 RFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAIVS 482
RFKDKERPRGYTSK+ G+LHYYPLEEVL AEYLLEEFRPDLIEMVLDKLRPENVRVAIVS
Sbjct: 705 RFKDKERPRGYTSKLGGMLHYYPLEEVLAAEYLLEEFRPDLIEMVLDKLRPENVRVAIVS 764
Query: 483 KSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPLEK 542
KSFEGKTD+TEEWYGTQYKQEAI DEVIKKWQNADLNGKFKLP KNEFIP+NFEIL LEK
Sbjct: 765 KSFEGKTDQTEEWYGTQYKQEAISDEVIKKWQNADLNGKFKLPMKNEFIPSNFEILQLEK 824
Query: 543 EATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELLKD 602
EA YPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELLKD
Sbjct: 825 EAPSYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELLKD 884
Query: 603 SLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFEII 662
SLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKI+EKMATFEIDEKRFEII
Sbjct: 885 SLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIVEKMATFEIDEKRFEII 944
Query: 663 KEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSR 722
KEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSR
Sbjct: 945 KEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSR 1004
Query: 723 LHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQR 782
LHIEALLHGNITKQAALG+MQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQR
Sbjct: 1005 LHIEALLHGNITKQAALGVMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQR 1064
Query: 783 NEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRANG 842
NEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRANG
Sbjct: 1065 NEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRANG 1124
Query: 843 IQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKLSA 902
IQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKLSA
Sbjct: 1125 IQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKLSA 1184
Query: 903 ECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLARE 962
ECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDII+FYKEMLAV+APRRHKVSVHVLARE
Sbjct: 1185 ECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIRFYKEMLAVEAPRRHKVSVHVLARE 1244
Query: 963 MDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL 1019
MDSCPVVGEFPCQND+NL+ APALPQPEVI+NMT FKR LPLFPLVKPHIN MAAKL
Sbjct: 1245 MDSCPVVGEFPCQNDVNLAAAPALPQPEVIENMTAFKRSLPLFPLVKPHINLMAAKL 1301
>ref|XP_534963.2| PREDICTED: similar to Insulin-degrading enzyme (Insulysin)
(Insulinase) (Insulin protease) [Canis familiaris]
Length = 994
Score = 1392 bits (3603), Expect = 0.0, Method: Composition-based stats.
Identities = 980/1019 (96%), Positives = 986/1019 (96%), Gaps = 25/1019 (2%)
Query: 1 MRYRLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED 60
MRY LAWLLH A PSTFRSVLGARLP PERLCGFQ+K+YSKMNNPAIKR+GNHI KSPED
Sbjct: 1 MRYPLAWLLHSARPSTFRSVLGARLPLPERLCGFQEKSYSKMNNPAIKRLGNHIIKSPED 60
Query: 61 KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK 120
KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK
Sbjct: 61 KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK 120
Query: 121 YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD 180
YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD
Sbjct: 121 YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD 180
Query: 181 REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE 240
REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE
Sbjct: 181 REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE 240
Query: 241 LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ 300
LLKFHS YYSSNLMA+CVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ
Sbjct: 241 LLKFHSTYYSSNLMAICVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ 300
Query: 301 LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV 360
LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV
Sbjct: 301 LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV 360
Query: 361 GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 420
GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV
Sbjct: 361 GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 420
Query: 421 AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI 480
AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI
Sbjct: 421 AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI 480
Query: 481 VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL 540
VSKSFEGKTDRTEEWYGTQYKQEA+PDEVIK IL L
Sbjct: 481 VSKSFEGKTDRTEEWYGTQYKQEAVPDEVIK-------------------------ILSL 515
Query: 541 EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL 600
EKEA PYP+LIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL
Sbjct: 516 EKEAHPYPSLIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL 575
Query: 601 KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE 660
KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE
Sbjct: 576 KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE 635
Query: 661 IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 720
IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL
Sbjct: 636 IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 695
Query: 721 SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 780
SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ
Sbjct: 696 SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 755
Query: 781 QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 840
QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA
Sbjct: 756 QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 815
Query: 841 NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL 900
NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL
Sbjct: 816 NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL 875
Query: 901 SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA 960
SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA
Sbjct: 876 SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA 935
Query: 961 REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL 1019
REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL
Sbjct: 936 REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL 994
>ref|XP_001146520.1| PREDICTED: insulysin isoform 2 [Pan troglodytes]
gb|EAW50093.1| insulin-degrading enzyme, isoform CRA_c [Homo sapiens]
Length = 978
Score = 1386 bits (3588), Expect = 0.0, Method: Composition-based stats.
Identities = 978/978 (100%), Positives = 978/978 (100%)
Query: 42 MNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPP 101
MNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPP
Sbjct: 1 MNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPP 60
Query: 102 NIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGA 161
NIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGA
Sbjct: 61 NIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGA 120
Query: 162 LDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTG 221
LDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTG
Sbjct: 121 LDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTG 180
Query: 222 NKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENK 281
NKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENK
Sbjct: 181 NKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENK 240
Query: 282 NVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHE 341
NVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHE
Sbjct: 241 NVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHE 300
Query: 342 GPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKL 401
GPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKL
Sbjct: 301 GPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKL 360
Query: 402 RAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRP 461
RAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRP
Sbjct: 361 RAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRP 420
Query: 462 DLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGK 521
DLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGK
Sbjct: 421 DLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGK 480
Query: 522 FKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSP 581
FKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSP
Sbjct: 481 FKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSP 540
Query: 582 FAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPIL 641
FAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPIL
Sbjct: 541 FAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPIL 600
Query: 642 LKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELK 701
LKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELK
Sbjct: 601 LKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELK 660
Query: 702 EALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPS 761
EALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPS
Sbjct: 661 EALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPS 720
Query: 762 QLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFN 821
QLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFN
Sbjct: 721 QLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFN 780
Query: 822 TLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEA 881
TLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEA
Sbjct: 781 TLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEA 840
Query: 882 FQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYK 941
FQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYK
Sbjct: 841 FQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYK 900
Query: 942 EMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRG 1001
EMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRG
Sbjct: 901 EMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRG 960
Query: 1002 LPLFPLVKPHINFMAAKL 1019
LPLFPLVKPHINFMAAKL
Sbjct: 961 LPLFPLVKPHINFMAAKL 978
>pdb|2G47|A Chain A, Crystal Structure Of Human Insulin-Degrading Enzyme In
Complex With Amyloid-Beta (1-40)
pdb|2G47|B Chain B, Crystal Structure Of Human Insulin-Degrading Enzyme In
Complex With Amyloid-Beta (1-40)
pdb|2G48|A Chain A, Crystal Structure Of Human Insulin-Degrading Enzyme In
Complex With Amylin
pdb|2G48|B Chain B, Crystal Structure Of Human Insulin-Degrading Enzyme In
Complex With Amylin
pdb|2G49|A Chain A, Crystal Structure Of Human Insulin-Degrading Enzyme In
Complex With Glucagon
pdb|2G49|B Chain B, Crystal Structure Of Human Insulin-Degrading Enzyme In
Complex With Glucagon
pdb|2G54|A Chain A, Crystal Structure Of Zn-Bound Human Insulin-Degrading Enzyme
In Complex With Insulin B Chain
pdb|2G54|B Chain B, Crystal Structure Of Zn-Bound Human Insulin-Degrading Enzyme
In Complex With Insulin B Chain
pdb|2G56|A Chain A, Crystal Structure Of Human Insulin-Degrading Enzyme In
Complex With Insulin B Chain
pdb|2G56|B Chain B, Crystal Structure Of Human Insulin-Degrading Enzyme In
Complex With Insulin B Chain
pdb|2JBU|A Chain A, Crystal Structure Of Human Insulin Degrading Enzyme
Complexed With Co-Purified Peptides.
pdb|2JBU|B Chain B, Crystal Structure Of Human Insulin Degrading Enzyme
Complexed With Co-Purified Peptides.
Length = 990
Score = 1386 bits (3587), Expect = 0.0, Method: Composition-based stats.
Identities = 977/978 (99%), Positives = 978/978 (100%)
Query: 42 MNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPP 101
MNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPP
Sbjct: 13 MNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPP 72
Query: 102 NIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGA 161
NIAGLSHFC+HMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGA
Sbjct: 73 NIAGLSHFCQHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGA 132
Query: 162 LDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTG 221
LDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTG
Sbjct: 133 LDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTG 192
Query: 222 NKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENK 281
NKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENK
Sbjct: 193 NKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENK 252
Query: 282 NVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHE 341
NVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHE
Sbjct: 253 NVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHE 312
Query: 342 GPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKL 401
GPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKL
Sbjct: 313 GPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKL 372
Query: 402 RAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRP 461
RAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRP
Sbjct: 373 RAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRP 432
Query: 462 DLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGK 521
DLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGK
Sbjct: 433 DLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGK 492
Query: 522 FKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSP 581
FKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSP
Sbjct: 493 FKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSP 552
Query: 582 FAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPIL 641
FAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPIL
Sbjct: 553 FAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPIL 612
Query: 642 LKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELK 701
LKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELK
Sbjct: 613 LKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELK 672
Query: 702 EALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPS 761
EALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPS
Sbjct: 673 EALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPS 732
Query: 762 QLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFN 821
QLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFN
Sbjct: 733 QLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFN 792
Query: 822 TLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEA 881
TLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEA
Sbjct: 793 TLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEA 852
Query: 882 FQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYK 941
FQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYK
Sbjct: 853 FQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYK 912
Query: 942 EMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRG 1001
EMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRG
Sbjct: 913 EMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRG 972
Query: 1002 LPLFPLVKPHINFMAAKL 1019
LPLFPLVKPHINFMAAKL
Sbjct: 973 LPLFPLVKPHINFMAAKL 990
>ref|XP_001090137.1| PREDICTED: insulysin isoform 2 [Macaca mulatta]
Length = 978
Score = 1386 bits (3587), Expect = 0.0, Method: Composition-based stats.
Identities = 974/978 (99%), Positives = 977/978 (99%)
Query: 42 MNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPP 101
MNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPP
Sbjct: 1 MNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPP 60
Query: 102 NIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGA 161
NIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGA
Sbjct: 61 NIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGA 120
Query: 162 LDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTG 221
LDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTG
Sbjct: 121 LDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTG 180
Query: 222 NKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENK 281
NKYTLETRPNQEGIDVRQELLKFHS YYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENK
Sbjct: 181 NKYTLETRPNQEGIDVRQELLKFHSTYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENK 240
Query: 282 NVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHE 341
+VPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHE
Sbjct: 241 SVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHE 300
Query: 342 GPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKL 401
GPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKL
Sbjct: 301 GPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKL 360
Query: 402 RAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRP 461
RAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRP
Sbjct: 361 RAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRP 420
Query: 462 DLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGK 521
DLIEMVLDKLRPENVRVA+VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGK
Sbjct: 421 DLIEMVLDKLRPENVRVAVVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGK 480
Query: 522 FKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSP 581
FKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSP
Sbjct: 481 FKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSP 540
Query: 582 FAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPIL 641
FAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPIL
Sbjct: 541 FAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPIL 600
Query: 642 LKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELK 701
LKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELK
Sbjct: 601 LKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELK 660
Query: 702 EALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPS 761
EALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPS
Sbjct: 661 EALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPS 720
Query: 762 QLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFN 821
QLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFN
Sbjct: 721 QLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFN 780
Query: 822 TLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEA 881
TLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEA
Sbjct: 781 TLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEA 840
Query: 882 FQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYK 941
FQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQY+FDRDNTEVAYLKTLTKEDIIKFYK
Sbjct: 841 FQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYHFDRDNTEVAYLKTLTKEDIIKFYK 900
Query: 942 EMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRG 1001
EMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRG
Sbjct: 901 EMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRG 960
Query: 1002 LPLFPLVKPHINFMAAKL 1019
LPLFPLVKPHINFMAAKL
Sbjct: 961 LPLFPLVKPHINFMAAKL 978
>pdb|2JG4|A Chain A, Substrate-Free Ide Structure In Its Closed Conformation
pdb|2JG4|B Chain B, Substrate-Free Ide Structure In Its Closed Conformation
Length = 990
Score = 1386 bits (3587), Expect = 0.0, Method: Composition-based stats.
Identities = 977/978 (99%), Positives = 978/978 (100%)
Query: 42 MNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPP 101
MNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPP
Sbjct: 13 MNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPP 72
Query: 102 NIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGA 161
NIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGA
Sbjct: 73 NIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGA 132
Query: 162 LDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTG 221
LDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTG
Sbjct: 133 LDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTG 192
Query: 222 NKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENK 281
NKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENK
Sbjct: 193 NKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENK 252
Query: 282 NVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHE 341
NVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHE
Sbjct: 253 NVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHE 312
Query: 342 GPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKL 401
GPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKL
Sbjct: 313 GPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKL 372
Query: 402 RAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRP 461
RAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRP
Sbjct: 373 RAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRP 432
Query: 462 DLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGK 521
DLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGK
Sbjct: 433 DLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGK 492
Query: 522 FKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSP 581
FKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSP
Sbjct: 493 FKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSP 552
Query: 582 FAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPIL 641
FAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPIL
Sbjct: 553 FAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPIL 612
Query: 642 LKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELK 701
LKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELK
Sbjct: 613 LKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELK 672
Query: 702 EALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPS 761
EALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPS
Sbjct: 673 EALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPS 732
Query: 762 QLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFN 821
QLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFN
Sbjct: 733 QLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFN 792
Query: 822 TLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEA 881
TLRTKEQLG+IVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEA
Sbjct: 793 TLRTKEQLGFIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEA 852
Query: 882 FQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYK 941
FQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYK
Sbjct: 853 FQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYK 912
Query: 942 EMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRG 1001
EMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRG
Sbjct: 913 EMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRG 972
Query: 1002 LPLFPLVKPHINFMAAKL 1019
LPLFPLVKPHINFMAAKL
Sbjct: 973 LPLFPLVKPHINFMAAKL 990
>gb|EDL41785.1| insulin degrading enzyme [Mus musculus]
Length = 978
Score = 1367 bits (3538), Expect = 0.0, Method: Composition-based stats.
Identities = 941/978 (96%), Positives = 963/978 (98%)
Query: 42 MNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPP 101
M+NPAI+RI + I KSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPP
Sbjct: 1 MSNPAIQRIEDQIVKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPP 60
Query: 102 NIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGA 161
NI GLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGA
Sbjct: 61 NIPGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGA 120
Query: 162 LDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTG 221
LDRFAQFFLCPLFD SCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTG
Sbjct: 121 LDRFAQFFLCPLFDASCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTG 180
Query: 222 NKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENK 281
NKYTLETRPNQEGIDVR+ELLKFHS YYSSNLMA+CVLGRESLDDLTNLVVKLFSEVENK
Sbjct: 181 NKYTLETRPNQEGIDVREELLKFHSTYYSSNLMAICVLGRESLDDLTNLVVKLFSEVENK 240
Query: 282 NVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHE 341
NVPLPEFPEHPFQEEHL+QLYKIVPIKDIRNLYVTFPIPDLQ+YYKSNPGHYLGHLIGHE
Sbjct: 241 NVPLPEFPEHPFQEEHLRQLYKIVPIKDIRNLYVTFPIPDLQQYYKSNPGHYLGHLIGHE 300
Query: 342 GPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKL 401
GPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKL
Sbjct: 301 GPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKL 360
Query: 402 RAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRP 461
RAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAG LHYYPL VLTAEYLLEEFRP
Sbjct: 361 RAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGKLHYYPLNGVLTAEYLLEEFRP 420
Query: 462 DLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGK 521
DLI+MVLDKLRPENVRVAIVSKSFEGKTDRTE+WYGTQYKQEAIP+++I+KWQNADLNGK
Sbjct: 421 DLIDMVLDKLRPENVRVAIVSKSFEGKTDRTEQWYGTQYKQEAIPEDIIQKWQNADLNGK 480
Query: 522 FKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSP 581
FKLPTKNEFIPTNFEIL LEK+ATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSP
Sbjct: 481 FKLPTKNEFIPTNFEILSLEKDATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSP 540
Query: 582 FAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPIL 641
FAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPIL
Sbjct: 541 FAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPIL 600
Query: 642 LKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELK 701
LKKI EKMATFEID+KRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELK
Sbjct: 601 LKKITEKMATFEIDKKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELK 660
Query: 702 EALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPS 761
EALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALG+MQMVEDTLIEHAHTKPLLPS
Sbjct: 661 EALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGVMQMVEDTLIEHAHTKPLLPS 720
Query: 762 QLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFN 821
QLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFN
Sbjct: 721 QLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFN 780
Query: 822 TLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEA 881
TLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEK+IEDMTEEA
Sbjct: 781 TLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKAIEDMTEEA 840
Query: 882 FQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYK 941
FQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYN+DRDN EVAYLKTLTK+DII+FY+
Sbjct: 841 FQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNYDRDNIEVAYLKTLTKDDIIRFYQ 900
Query: 942 EMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRG 1001
EMLAVDAPRRHKVSVHVLAREMDSCPVVGEFP QNDINLS+AP LPQPEVI NMTEFKRG
Sbjct: 901 EMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPSQNDINLSEAPPLPQPEVIHNMTEFKRG 960
Query: 1002 LPLFPLVKPHINFMAAKL 1019
LPLFPLVKPHINFMAAKL
Sbjct: 961 LPLFPLVKPHINFMAAKL 978
>pdb|2WBY|A Chain A, Crystal Structure Of Human Insulin-Degrading Enzyme In
Complex With Insulin
pdb|2WBY|B Chain B, Crystal Structure Of Human Insulin-Degrading Enzyme In
Complex With Insulin
pdb|2WC0|A Chain A, Crystal Structure Of Human Insulin Degrading Enzyme In
Complex With Iodinated Insulin
pdb|2WC0|B Chain B, Crystal Structure Of Human Insulin Degrading Enzyme In
Complex With Iodinated Insulin
Length = 990
Score = 1364 bits (3531), Expect = 0.0, Method: Composition-based stats.
Identities = 964/978 (98%), Positives = 965/978 (98%)
Query: 42 MNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPP 101
MNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPP
Sbjct: 13 MNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPP 72
Query: 102 NIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGA 161
NIAGLSHF +HMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGA
Sbjct: 73 NIAGLSHFLQHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGA 132
Query: 162 LDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTG 221
LDRFAQFFL PLFDES KDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTG
Sbjct: 133 LDRFAQFFLSPLFDESAKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTG 192
Query: 222 NKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENK 281
NKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAV VLGRESLDDLTNLVVKLFSEVENK
Sbjct: 193 NKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVVVLGRESLDDLTNLVVKLFSEVENK 252
Query: 282 NVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHE 341
NVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHE
Sbjct: 253 NVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHE 312
Query: 342 GPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKL 401
GPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKL
Sbjct: 313 GPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKL 372
Query: 402 RAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRP 461
RAEGPQEWVFQE KDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRP
Sbjct: 373 RAEGPQEWVFQELKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRP 432
Query: 462 DLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGK 521
DLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGK
Sbjct: 433 DLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGK 492
Query: 522 FKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSP 581
FKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKA LNFEFFSP
Sbjct: 493 FKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKANLNFEFFSP 552
Query: 582 FAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPIL 641
FAYVDPLH NMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPIL
Sbjct: 553 FAYVDPLHSNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPIL 612
Query: 642 LKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELK 701
LKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELK
Sbjct: 613 LKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELK 672
Query: 702 EALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPS 761
EALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPS
Sbjct: 673 EALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPS 732
Query: 762 QLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFN 821
QLVRYREVQLPDRGWFVYQQRNEVHNN GIEIYYQTDMQSTSENMFLELF QIISEP FN
Sbjct: 733 QLVRYREVQLPDRGWFVYQQRNEVHNNSGIEIYYQTDMQSTSENMFLELFAQIISEPAFN 792
Query: 822 TLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEA 881
TLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEA
Sbjct: 793 TLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEA 852
Query: 882 FQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYK 941
FQKHIQALAIRRLDKPKKLSAE AKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYK
Sbjct: 853 FQKHIQALAIRRLDKPKKLSAESAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYK 912
Query: 942 EMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRG 1001
EMLAVDAPRRHKVSVHVLAREMDS PVVGEFP QNDINLSQAPALPQPEVIQNMTEFKRG
Sbjct: 913 EMLAVDAPRRHKVSVHVLAREMDSNPVVGEFPAQNDINLSQAPALPQPEVIQNMTEFKRG 972
Query: 1002 LPLFPLVKPHINFMAAKL 1019
LPLFPLVKPHINFMAAKL
Sbjct: 973 LPLFPLVKPHINFMAAKL 990
>ref|NP_001082994.1| insulin-degrading enzyme [Danio rerio]
gb|AAI39608.1| Zgc:162603 protein [Danio rerio]
Length = 978
Score = 1341 bits (3472), Expect = 0.0, Method: Composition-based stats.
Identities = 873/978 (89%), Positives = 937/978 (95%)
Query: 42 MNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPP 101
M++PA+KR+ + I +SPEDKREYRGLE NG+K +LISDPTTDKSSAALDVH+GSLSDP
Sbjct: 1 MSDPAVKRVVSDIIRSPEDKREYRGLEFTNGLKAILISDPTTDKSSAALDVHMGSLSDPE 60
Query: 102 NIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGA 161
NI+GL+HFCEHMLFLGT+KYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHL+GA
Sbjct: 61 NISGLAHFCEHMLFLGTEKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLQGA 120
Query: 162 LDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTG 221
LDRFAQFFLCPLFDESCKDREVNAVDSEHEKN+MNDAWRLFQLEKATGNPKHPFSKFGTG
Sbjct: 121 LDRFAQFFLCPLFDESCKDREVNAVDSEHEKNLMNDAWRLFQLEKATGNPKHPFSKFGTG 180
Query: 222 NKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENK 281
NK TLETRP+Q+GID+R+ELLKFHS YYSSNLM +CVLGRE+LD+LT++VVKLF EVENK
Sbjct: 181 NKLTLETRPSQQGIDIREELLKFHSTYYSSNLMGLCVLGRETLDELTSMVVKLFGEVENK 240
Query: 282 NVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHE 341
NVP+PEFP HPFQEEHL+Q YK+VPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHE
Sbjct: 241 NVPVPEFPTHPFQEEHLRQFYKVVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHE 300
Query: 342 GPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKL 401
GPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDII HMFQYIQKL
Sbjct: 301 GPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIIFHMFQYIQKL 360
Query: 402 RAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRP 461
R EGPQEWVFQECKDLN VAFRFKDKERPRGYTSK+AG+LHYYPLEE+L AEYLLEEFRP
Sbjct: 361 RTEGPQEWVFQECKDLNTVAFRFKDKERPRGYTSKVAGLLHYYPLEEILAAEYLLEEFRP 420
Query: 462 DLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGK 521
DLIEMVLDKLRPENVRVA+VSKSFEG+TDRTEEWYGTQYKQEAI DE IKKW NADLNGK
Sbjct: 421 DLIEMVLDKLRPENVRVAVVSKSFEGQTDRTEEWYGTQYKQEAITDEAIKKWDNADLNGK 480
Query: 522 FKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSP 581
FKLP KNEFIPTNFEI PLEK++ P LIKDTAMSK+WFKQDDKFFLPKACLNFEFFSP
Sbjct: 481 FKLPMKNEFIPTNFEIYPLEKDSPSAPTLIKDTAMSKVWFKQDDKFFLPKACLNFEFFSP 540
Query: 582 FAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPIL 641
FAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNT+YGMYLSVKGYNDKQ IL
Sbjct: 541 FAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTVYGMYLSVKGYNDKQHIL 600
Query: 642 LKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELK 701
LKKIIEKMATFEIDEKRF+IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDEL+
Sbjct: 601 LKKIIEKMATFEIDEKRFDIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELR 660
Query: 702 EALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPS 761
+ALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQ+AL +MQM+EDTLIEHAHTKPLLPS
Sbjct: 661 DALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQSALEMMQMLEDTLIEHAHTKPLLPS 720
Query: 762 QLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFN 821
QL+RYREVQ+PD GW+VYQQRNEVHNNCGIEIYYQTDMQ+T ENM LELFCQIISEPCFN
Sbjct: 721 QLIRYREVQVPDGGWYVYQQRNEVHNNCGIEIYYQTDMQNTHENMLLELFCQIISEPCFN 780
Query: 822 TLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEA 881
TLRTKEQLGYIVFSGPRRANG+QGLRFIIQSEK PHYLESRVEAFL TMEKS+E+M +EA
Sbjct: 781 TLRTKEQLGYIVFSGPRRANGVQGLRFIIQSEKAPHYLESRVEAFLKTMEKSVEEMGDEA 840
Query: 882 FQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYK 941
FQKHIQALAIRRLDKPKKL+AECAKYWGEIISQQYNFDRDN EVAYLKTLTKE I++FY+
Sbjct: 841 FQKHIQALAIRRLDKPKKLAAECAKYWGEIISQQYNFDRDNIEVAYLKTLTKEHIMQFYR 900
Query: 942 EMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRG 1001
++LA+DAPRRHKVSVHVL+REMDSCP+VGEFP QND+NL+ AP+LPQP ++Q+MTEFKR
Sbjct: 901 DLLAIDAPRRHKVSVHVLSREMDSCPLVGEFPAQNDVNLAPAPSLPQPSLVQDMTEFKRS 960
Query: 1002 LPLFPLVKPHINFMAAKL 1019
LPLFPL KPHINFMAAKL
Sbjct: 961 LPLFPLTKPHINFMAAKL 978
>dbj|BAF62161.1| insulin-degrading enzyme [Danio rerio]
Length = 998
Score = 1341 bits (3471), Expect = 0.0, Method: Composition-based stats.
Identities = 871/979 (88%), Positives = 936/979 (95%)
Query: 41 KMNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDP 100
+M++PA+KR+ + I +SPEDKREYRGLE NG+K +LISDPTTDKSSAALDVH+GSLSDP
Sbjct: 20 RMSDPAVKRVVSDIIRSPEDKREYRGLESTNGLKAILISDPTTDKSSAALDVHMGSLSDP 79
Query: 101 PNIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEG 160
NI+GL+HFCEHMLFLGT+KYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHL+G
Sbjct: 80 ENISGLAHFCEHMLFLGTEKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLQG 139
Query: 161 ALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGT 220
ALDRFAQFFLCPLFDESCKDREVNAVDSEHEKN+MNDAWRLFQLEKATGNPKHPFSKFGT
Sbjct: 140 ALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNLMNDAWRLFQLEKATGNPKHPFSKFGT 199
Query: 221 GNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVEN 280
GNK TLETRP+Q+GID+R+ELLKFHS YYSSNLM +CVLGRE+LD+LT++VVKLF EVEN
Sbjct: 200 GNKLTLETRPSQQGIDIREELLKFHSTYYSSNLMGLCVLGRETLDELTSMVVKLFGEVEN 259
Query: 281 KNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGH 340
KNVP+PEFP HPFQEEHL+Q YK+VPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGH
Sbjct: 260 KNVPVPEFPTHPFQEEHLRQFYKVVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGH 319
Query: 341 EGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQK 400
EGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDII HMFQYIQK
Sbjct: 320 EGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIIFHMFQYIQK 379
Query: 401 LRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFR 460
LR EGPQEWVFQECKDLN VAFRFKDKERPRGYTSK+AG+LHYYPLEE+L AEYLLEEFR
Sbjct: 380 LRTEGPQEWVFQECKDLNTVAFRFKDKERPRGYTSKVAGLLHYYPLEEILAAEYLLEEFR 439
Query: 461 PDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNG 520
PDLIEMVLDKLRPENVRVA+VSKSFEG+TDRTEEWYGTQYKQEAI DE IKKW NADLNG
Sbjct: 440 PDLIEMVLDKLRPENVRVAVVSKSFEGQTDRTEEWYGTQYKQEAITDEAIKKWDNADLNG 499
Query: 521 KFKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFS 580
KFKLP KNEFIPTNFEI PLEK++ P LIKDTAMSK+WFKQDDKFFLPKACLNFEFFS
Sbjct: 500 KFKLPMKNEFIPTNFEIYPLEKDSPSAPTLIKDTAMSKVWFKQDDKFFLPKACLNFEFFS 559
Query: 581 PFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPI 640
PFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNT+YGMYLSVKGYNDKQ I
Sbjct: 560 PFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTVYGMYLSVKGYNDKQHI 619
Query: 641 LLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDEL 700
LLKKIIEKMATFEIDEKRF+IIKEAYMR LNNFRAEQPHQHAMYYLRLLMTEVAWTKDEL
Sbjct: 620 LLKKIIEKMATFEIDEKRFDIIKEAYMRPLNNFRAEQPHQHAMYYLRLLMTEVAWTKDEL 679
Query: 701 KEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLP 760
++ALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQ+AL +MQM+EDTLIEHAHTKPLLP
Sbjct: 680 RDALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQSALEMMQMLEDTLIEHAHTKPLLP 739
Query: 761 SQLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCF 820
SQL+RYREVQ+PD GW+VYQQRNEVHNNCGIEIYYQTDMQ+T ENM LELFCQIISEPCF
Sbjct: 740 SQLIRYREVQVPDGGWYVYQQRNEVHNNCGIEIYYQTDMQNTHENMLLELFCQIISEPCF 799
Query: 821 NTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEE 880
NTLRTKEQLGYIVFSGPRRANG+QGLRFIIQSEK PHYLESRVEAFL TMEKS+E+M +E
Sbjct: 800 NTLRTKEQLGYIVFSGPRRANGVQGLRFIIQSEKAPHYLESRVEAFLKTMEKSVEEMGDE 859
Query: 881 AFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFY 940
AFQKHIQALAIRRLDKPKKL+AECAKYWGEIISQQYNFDRDN EVAYLKTLTKE I++FY
Sbjct: 860 AFQKHIQALAIRRLDKPKKLAAECAKYWGEIISQQYNFDRDNIEVAYLKTLTKEHIMQFY 919
Query: 941 KEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKR 1000
+++LA+DAPRRHKVSVHVL+REMDSCP+VGEFP QND+NL+ AP+LPQP ++Q+MTEFKR
Sbjct: 920 RDLLAIDAPRRHKVSVHVLSREMDSCPLVGEFPAQNDVNLAPAPSLPQPSLVQDMTEFKR 979
Query: 1001 GLPLFPLVKPHINFMAAKL 1019
LPLFPL KPHINFMAA L
Sbjct: 980 SLPLFPLTKPHINFMAANL 998
>ref|XP_001146439.1| PREDICTED: insulysin isoform 1 [Pan troglodytes]
Length = 861
Score = 1179 bits (3050), Expect = 0.0, Method: Composition-based stats.
Identities = 856/856 (100%), Positives = 856/856 (100%)
Query: 164 RFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNK 223
RFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNK
Sbjct: 6 RFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNK 65
Query: 224 YTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNV 283
YTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNV
Sbjct: 66 YTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNV 125
Query: 284 PLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGP 343
PLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGP
Sbjct: 126 PLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGP 185
Query: 344 GSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRA 403
GSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRA
Sbjct: 186 GSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRA 245
Query: 404 EGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDL 463
EGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDL
Sbjct: 246 EGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDL 305
Query: 464 IEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFK 523
IEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFK
Sbjct: 306 IEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFK 365
Query: 524 LPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFA 583
LPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFA
Sbjct: 366 LPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFA 425
Query: 584 YVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLK 643
YVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLK
Sbjct: 426 YVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLK 485
Query: 644 KIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEA 703
KIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEA
Sbjct: 486 KIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEA 545
Query: 704 LDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQL 763
LDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQL
Sbjct: 546 LDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQL 605
Query: 764 VRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTL 823
VRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTL
Sbjct: 606 VRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTL 665
Query: 824 RTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQ 883
RTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQ
Sbjct: 666 RTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQ 725
Query: 884 KHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEM 943
KHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEM
Sbjct: 726 KHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEM 785
Query: 944 LAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLP 1003
LAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLP
Sbjct: 786 LAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLP 845
Query: 1004 LFPLVKPHINFMAAKL 1019
LFPLVKPHINFMAAKL
Sbjct: 846 LFPLVKPHINFMAAKL 861
>ref|XP_001090017.1| PREDICTED: insulysin isoform 1 [Macaca mulatta]
Length = 861
Score = 1178 bits (3048), Expect = 0.0, Method: Composition-based stats.
Identities = 852/856 (99%), Positives = 855/856 (99%)
Query: 164 RFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNK 223
RFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNK
Sbjct: 6 RFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNK 65
Query: 224 YTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNV 283
YTLETRPNQEGIDVRQELLKFHS YYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENK+V
Sbjct: 66 YTLETRPNQEGIDVRQELLKFHSTYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKSV 125
Query: 284 PLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGP 343
PLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGP
Sbjct: 126 PLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGP 185
Query: 344 GSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRA 403
GSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRA
Sbjct: 186 GSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRA 245
Query: 404 EGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDL 463
EGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDL
Sbjct: 246 EGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDL 305
Query: 464 IEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFK 523
IEMVLDKLRPENVRVA+VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFK
Sbjct: 306 IEMVLDKLRPENVRVAVVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFK 365
Query: 524 LPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFA 583
LPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFA
Sbjct: 366 LPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFA 425
Query: 584 YVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLK 643
YVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLK
Sbjct: 426 YVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLK 485
Query: 644 KIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEA 703
KIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEA
Sbjct: 486 KIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEA 545
Query: 704 LDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQL 763
LDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQL
Sbjct: 546 LDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQL 605
Query: 764 VRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTL 823
VRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTL
Sbjct: 606 VRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTL 665
Query: 824 RTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQ 883
RTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQ
Sbjct: 666 RTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQ 725
Query: 884 KHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEM 943
KHIQALAIRRLDKPKKLSAECAKYWGEIISQQY+FDRDNTEVAYLKTLTKEDIIKFYKEM
Sbjct: 726 KHIQALAIRRLDKPKKLSAECAKYWGEIISQQYHFDRDNTEVAYLKTLTKEDIIKFYKEM 785
Query: 944 LAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLP 1003
LAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLP
Sbjct: 786 LAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLP 845
Query: 1004 LFPLVKPHINFMAAKL 1019
LFPLVKPHINFMAAKL
Sbjct: 846 LFPLVKPHINFMAAKL 861
>ref|XP_001847597.1| metalloprotease [Culex pipiens quinquefasciatus]
gb|EDS26498.1| metalloprotease [Culex pipiens quinquefasciatus]
Length = 998
Score = 1147 bits (2968), Expect = 0.0, Method: Composition-based stats.
Identities = 484/965 (50%), Positives = 678/965 (70%), Gaps = 1/965 (0%)
Query: 52 NHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCE 111
+ I KS +D R YRGL L+NG+KVLLISDPTTDKS+AAL V +G LSDP I GL+HFCE
Sbjct: 26 DDIVKSQQDNRLYRGLRLSNGLKVLLISDPTTDKSAAALAVEVGHLSDPDEIPGLAHFCE 85
Query: 112 HMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLC 171
HMLFLGTKKY EN+Y FLSE+ GSSNA T + T YYFDV E L+ ALDRF+QFF+
Sbjct: 86 HMLFLGTKKYINENDYMAFLSENGGSSNAATYADTTKYYFDVVPEKLQEALDRFSQFFIA 145
Query: 172 PLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPN 231
PLF ES +RE+NAV SEHEKN+ D WR+ Q+ K+ +PKHP++KFGTG+K TL P
Sbjct: 146 PLFTESATEREINAVHSEHEKNLSMDVWRIRQVNKSLCDPKHPYNKFGTGSKKTLLEDPK 205
Query: 232 QEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEH 291
I++R+EL+KFHS +YS+N+M++ V G+ESLD+L ++VV +FS++ENKNV P + +
Sbjct: 206 LSKINIREELMKFHSKWYSANIMSLAVFGKESLDELESMVVSMFSDIENKNVTSPCWKDL 265
Query: 292 PFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELK 351
PF+EEHL +VP+KD R+L +TF DL++YYK+ P HY+ HLIGHEG GS+LSELK
Sbjct: 266 PFKEEHLATKTTVVPVKDTRSLTITFQTEDLERYYKAGPEHYVSHLIGHEGAGSILSELK 325
Query: 352 SKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVF 411
+KGW N LVGG RGF FF + VDLT++G HV+DI+ +FQYI L+ EGPQ+W+F
Sbjct: 326 AKGWCNNLVGGYSTIGRGFGFFEVMVDLTQDGFDHVDDIVKIIFQYIHMLKTEGPQKWIF 385
Query: 412 QECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKL 471
+E DL + FRFKDKE P S + + YPLEEVL A YL+ E+RP+LIE + +K
Sbjct: 386 EEYCDLCEMQFRFKDKENPLSLVSNVVHSMQSYPLEEVLAAPYLISEWRPELIEELWNKF 445
Query: 472 RPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFI 531
P+N R+ +V + E T++ EEWYGT+Y EAIP V+++W DLN LP +N FI
Sbjct: 446 FPQNARITVVGQKCESVTNQEEEWYGTKYSSEAIPKNVLEEWAKPDLNANLHLPERNPFI 505
Query: 532 PTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCN 591
PT+FE++P++ + P +I +T M ++WFKQD +F PK +N +F SP Y DPL+CN
Sbjct: 506 PTDFELVPVDADIQSTPVIIHNTPMIRVWFKQDVEFLKPKTLMNLDFCSPIVYSDPLNCN 565
Query: 592 MAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMAT 651
+ +L+++L KD LNEY YAA+LAGL + NT YG+ +S+ GY+ KQ ILL+K+++ +
Sbjct: 566 LTHLFVQLFKDHLNEYLYAADLAGLRLVVSNTTYGISVSIGGYSHKQHILLEKVLDNLYN 625
Query: 652 FEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPR 711
F+IDEKRF+I+KE Y+R+L N+ AEQP+QHA+YYL LL+TE AW+K EL +A D +++ R
Sbjct: 626 FKIDEKRFDILKEQYVRNLKNYNAEQPYQHAVYYLALLLTEQAWSKQELIDAADLLSVDR 685
Query: 712 LKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIE-HAHTKPLLPSQLVRYREVQ 770
L++FI +LLSR+H+E ++GN+ K+ AL I VED L A PLL QL+ RE +
Sbjct: 686 LRSFIDELLSRMHVECFIYGNVNKENALEISGKVEDKLKNTDASVVPLLARQLMLKREYK 745
Query: 771 LPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLG 830
L + +++ N+ H + E+Y Q MQ N+F++L QI+SEPC+N LRTKEQLG
Sbjct: 746 LNNGENCLFETNNDYHKSSCAELYLQCGMQDDQSNVFVDLVTQILSEPCYNQLRTKEQLG 805
Query: 831 YIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALA 890
YIVF G R++NG+QG+R I+QS K P Y+E R+E FL M + +E+M+EE F++H +ALA
Sbjct: 806 YIVFCGSRKSNGVQGIRVIVQSAKHPAYVEERIEHFLNGMIEQLENMSEEEFKRHKEALA 865
Query: 891 IRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPR 950
++L+KPK+LS + K+ EI QQY+F+R EVA+L+TLTK+ II++YK+ + + AP
Sbjct: 866 AQKLEKPKRLSTQFGKFLTEISLQQYHFNRAQVEVAFLQTLTKQQIIEYYKDYIILGAPS 925
Query: 951 RHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKP 1010
R +S+HV++ P + + ++ + ++ FK L+P+V+P
Sbjct: 926 RRSLSIHVVSTAEGGAGHRDAPPEATERSTNETADAKDFVKVCDLASFKSTRALYPMVQP 985
Query: 1011 HINFM 1015
+I+
Sbjct: 986 YIDIK 990
>ref|XP_971897.1| PREDICTED: similar to Insulin-degrading enzyme (Insulysin)
(Insulinase) (Insulin protease) [Tribolium castaneum]
Length = 977
Score = 1143 bits (2956), Expect = 0.0, Method: Composition-based stats.
Identities = 522/971 (53%), Positives = 718/971 (73%), Gaps = 8/971 (0%)
Query: 44 NPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNI 103
N ++R+ +I KS EDKR YRGLELAN +KVLL+SDPTTDKS+AA+DV++G +SDP ++
Sbjct: 6 NLVLRRV-ENIIKSQEDKRLYRGLELANHMKVLLVSDPTTDKSAAAMDVNVGFMSDPRDV 64
Query: 104 AGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALD 163
GL+HFCEHMLFLGTKKYP EN+Y+++LSEH GSSNA T +HT YYFD+ + L ALD
Sbjct: 65 YGLAHFCEHMLFLGTKKYPNENDYNKYLSEHGGSSNAATYPDHTIYYFDIVPDELNNALD 124
Query: 164 RFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNK 223
RF+QFF+ PLF ES DRE+NAV+SEHEKN+ ND WR QL+K +PKHP+ FGTGN+
Sbjct: 125 RFSQFFIAPLFTESATDREMNAVNSEHEKNIPNDVWRKDQLDKHLADPKHPYHTFGTGNR 184
Query: 224 YTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNV 283
+TL+T P ++ I+VR ELLKFH +YSSN+M + VLG+ESLDDL +VVKLFSEV++K +
Sbjct: 185 HTLDTLPKEKNINVRDELLKFHDKWYSSNIMCLAVLGKESLDDLEQMVVKLFSEVKDKAI 244
Query: 284 PLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGP 343
P + EHPF++EH + PIKD+RNL + FP DLQ+YYKS+P HY+ HL+GHEGP
Sbjct: 245 AAPRWEEHPFKDEHFGTCVYMYPIKDVRNLNIVFPCRDLQEYYKSSPSHYISHLMGHEGP 304
Query: 344 GSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRA 403
GS+LS LK++GW N LV G + RG FF + VDLTEEG+ H++DI+ +FQY+ L+
Sbjct: 305 GSILSTLKARGWSNNLVAGSRPAPRGLGFFGVTVDLTEEGIKHIDDIVELIFQYLNMLKR 364
Query: 404 EGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDL 463
+GPQ+WV E +D+ + FRFKDKE PR Y + + L Y +E+VL+ YL E+RPD+
Sbjct: 365 QGPQKWVQDENRDIGNMLFRFKDKESPRSYIAGLVHTLQDYSMEDVLSCMYLFSEWRPDI 424
Query: 464 IEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFK 523
IE V + PE +R+ +++K +E + D+ E WYGT+YK IP++ +++W+ ++L+G FK
Sbjct: 425 IEQVWNDFVPEKIRIVVLAKQYENELDQVEPWYGTKYKVAKIPEKTLERWRKSELSGDFK 484
Query: 524 LPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFA 583
LP KNEFIPT+FE+ P++KE T +P +I+DTA++++WFKQD+ F LPKA + F+F SP A
Sbjct: 485 LPEKNEFIPTDFELYPIDKEVTEHPVIIQDTALTRVWFKQDETFLLPKANVMFDFVSPLA 544
Query: 584 YVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLK 643
Y+DPL+CN+ ++ ++L +D+LNEYAYAAELAGL ++L NT YG+ L++ GY++KQ I L
Sbjct: 545 YLDPLNCNLTHMLVQLFRDALNEYAYAAELAGLKWELINTKYGLILAIGGYSNKQHIFLD 604
Query: 644 KIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEA 703
K++EK+ F+ID KRFEI KE Y+R+L NF AEQP+QHA+YYL L+TE +WTK EL
Sbjct: 605 KVMEKLTNFKIDPKRFEICKENYIRNLKNFAAEQPYQHAVYYLAALLTEHSWTKQELLAT 664
Query: 704 LDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQL 763
+ +T+ +L+AFIPQ+LS++HIE L+HGN K+ AL ++Q+VED L+ + PLLP QL
Sbjct: 665 TEQLTIDKLEAFIPQILSKMHIECLIHGNANKEKALQLVQIVEDRLLSTLNMSPLLPRQL 724
Query: 764 VRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTL 823
+ RE++L D +VY+ +NEVH IE+YYQ +QS NM LELF QI+ EPCF+ L
Sbjct: 725 LLNRELKLEDGCNYVYEVQNEVHKESCIELYYQCGLQSKENNMKLELFAQIVQEPCFDIL 784
Query: 824 RTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQ 883
RTKEQLGYIVFSG RR+NG+QGLR I+QS+K P L+ R+E FL M +++M+EE F
Sbjct: 785 RTKEQLGYIVFSGIRRSNGVQGLRIIVQSDKHPVRLDERIEEFLKNMLSYLKNMSEEEFA 844
Query: 884 KHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEM 943
+H +ALA +RL+KPK+LS + +WGEI SQQY+FDR N EVAYL+TLTKEDII FYK +
Sbjct: 845 RHREALAAQRLEKPKQLSTQTNIFWGEITSQQYHFDRANVEVAYLRTLTKEDIIDFYKSL 904
Query: 944 LAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLP 1003
L +A R K+SVHV++ + + ++ + V+ ++T FK
Sbjct: 905 LEENAQFRKKLSVHVVSMADGGAGKMAASDKEYTVD-------SKGTVVCDITVFKSSHE 957
Query: 1004 LFPLVKPHINF 1014
+ PLV+P+IN
Sbjct: 958 MHPLVQPYINI 968
>ref|XP_001661876.1| metalloprotease [Aedes aegypti]
gb|EAT36161.1| metalloprotease [Aedes aegypti]
Length = 1003
Score = 1140 bits (2950), Expect = 0.0, Method: Composition-based stats.
Identities = 483/965 (50%), Positives = 670/965 (69%), Gaps = 1/965 (0%)
Query: 52 NHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCE 111
++ITKS +D R YRGL+L NG+KVLLISDPTTDKS+AAL V +G LSDP I GL+HFCE
Sbjct: 31 DNITKSQQDSRNYRGLQLENGLKVLLISDPTTDKSAAALSVAVGHLSDPDEIPGLAHFCE 90
Query: 112 HMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLC 171
HMLFLGTKKY EN+Y FLSE+ GSSNA T + T YYFDV E L ALDRF+QFF+
Sbjct: 91 HMLFLGTKKYVNENDYMSFLSENGGSSNAATYADTTKYYFDVVPEKLPEALDRFSQFFIA 150
Query: 172 PLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPN 231
PLF ES +RE+NAV SEHEKN+ D WR+ Q+ K+ +PKHP++KFGTG+K TL P
Sbjct: 151 PLFTESATEREINAVHSEHEKNLSMDVWRIRQVNKSLCDPKHPYNKFGTGSKKTLLEDPK 210
Query: 232 QEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEH 291
I++R+EL+KFH+ +YS+N+M++ V G+ESLDDL ++VV +FSE+ENKNV PE+ +
Sbjct: 211 TTNINIREELMKFHAKWYSANIMSLAVFGKESLDDLESMVVGMFSEIENKNVTSPEWKDL 270
Query: 292 PFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELK 351
P++ + L K+VP+KD R+L +TF DL+++Y++ P HY HLIGHEG GS+LSELK
Sbjct: 271 PYKNDQLATKTKVVPVKDSRSLTITFQTEDLEQHYRAGPEHYASHLIGHEGAGSILSELK 330
Query: 352 SKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVF 411
+KGW N LVGG RGF FF + VDLT++G HV+DI+ +FQYI L+ EGPQ+W+F
Sbjct: 331 AKGWCNNLVGGYNTIGRGFGFFEVMVDLTQDGFEHVDDIVKIIFQYINMLKKEGPQKWIF 390
Query: 412 QECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKL 471
+E DL + FRFKDKE P S + + YPLEEVL A YL+ E+RPDLIE + +K
Sbjct: 391 EEYCDLCEMQFRFKDKENPLTLVSSVVHSMQSYPLEEVLAAPYLISEWRPDLIEDLWNKF 450
Query: 472 RPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFI 531
P+N R+ +V + E K EEWYGT+Y E I +V++ W +DLNG LP +N FI
Sbjct: 451 YPQNARITVVGQKCEAKATCEEEWYGTKYSTEKIDAKVLEDWAKSDLNGNLHLPERNPFI 510
Query: 532 PTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCN 591
PTNF++L ++ + P +I +T M ++WFKQD +F PK +N +F SP Y DPL+CN
Sbjct: 511 PTNFDLLAVDADIESIPVIIHNTPMMRVWFKQDVEFLKPKTLMNLDFCSPIVYSDPLNCN 570
Query: 592 MAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMAT 651
+ +L+++L KD LNEY YAA LAGL + NT YG+ +S+ GY+ KQ ILL+K+++ M
Sbjct: 571 LTHLFVQLFKDHLNEYLYAAGLAGLRLGVANTTYGVSVSIGGYSHKQHILLEKVLDDMFN 630
Query: 652 FEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPR 711
F+IDEKRFEI+KE Y+R+L N++AEQP+QHA+YYL LL+TE AW+K EL +A + VT+ R
Sbjct: 631 FKIDEKRFEILKEQYIRNLKNYQAEQPYQHAVYYLALLLTEQAWSKQELIDATELVTVDR 690
Query: 712 LKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIE-HAHTKPLLPSQLVRYREVQ 770
L+ FI +LLSR+H+E ++GN+ K+ AL + VED L + A+ PLL QL+ RE +
Sbjct: 691 LRTFIDELLSRMHVECFIYGNVNKEKALEMSSKVEDKLKKTDANVVPLLARQLMLKREYK 750
Query: 771 LPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLG 830
L + +++ NE H + E+Y Q MQ+ N++++L QI+SEPC+N LRTKEQLG
Sbjct: 751 LNNGENCLFEMTNEFHKSSCAELYLQCGMQNDQANVYVDLVTQILSEPCYNQLRTKEQLG 810
Query: 831 YIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALA 890
YIVF G R++NG+QG+R I+QS P ++E R+E FL M +E+MTEE F++H +ALA
Sbjct: 811 YIVFCGSRKSNGVQGIRVIVQSANHPAFVEERIEHFLNGMVDYLENMTEEEFKRHKEALA 870
Query: 891 IRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPR 950
+L+KPK+LS++ K+ EI QQY+F+R EVA+L+TLTK+ I+ +YKE + DA
Sbjct: 871 AMKLEKPKRLSSQFTKFLNEIALQQYHFNRAQVEVAFLQTLTKQQIVDYYKEYIVKDASL 930
Query: 951 RHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKP 1010
R +S+HV++ + A + ++ FK L+P+V+P
Sbjct: 931 RRSLSIHVVSTAEGGAGHKDASADVAKQSTDDASTQKDFVKVGDLAGFKSTRALYPMVQP 990
Query: 1011 HINFM 1015
+I+
Sbjct: 991 YIDIK 995
>ref|XP_001603463.1| PREDICTED: similar to metalloprotease [Nasonia vitripennis]
Length = 999
Score = 1138 bits (2944), Expect = 0.0, Method: Composition-based stats.
Identities = 525/987 (53%), Positives = 713/987 (72%), Gaps = 6/987 (0%)
Query: 31 LCGFQKKTYSKMNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAAL 90
L KK+ +K + R N+I KSP DKR+YRGL L N +KVLLISDP TDKS+A+L
Sbjct: 3 LSKSFKKSITKHQSKEPTR-YNNIVKSPNDKRDYRGLILHNKLKVLLISDPMTDKSAASL 61
Query: 91 DVHIGSLSDPPNIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYY 150
DV++G LSDP + GL+HFCEHMLFLGT KYP+ N+Y+Q+LS++ G+SNA T +HTNYY
Sbjct: 62 DVNVGYLSDPKELPGLAHFCEHMLFLGTTKYPEVNDYNQYLSQNGGASNAATYLDHTNYY 121
Query: 151 FDVSHEHLEGALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGN 210
FDV+ + LEGALDRF+QFF+ PLF ES ++E+ AV EHEKN+ ND WR+ QL+K++ +
Sbjct: 122 FDVNPDKLEGALDRFSQFFVSPLFTESATEKEITAVHLEHEKNIANDTWRMDQLDKSSAD 181
Query: 211 PKHPFSKFGTGNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNL 270
P H +SKFGTG+K TLE P Q+ IDVRQELL FH+ +YS+N+MA+ VLG+ESLDDL +
Sbjct: 182 PSHAYSKFGTGSKDTLEVIPKQKNIDVRQELLNFHNTWYSANIMALSVLGKESLDDLEKM 241
Query: 271 VVKLFSEVENKNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNP 330
+V +FS+++NKNV +P++P HPF +EH K + IVPIKDIRNL +TFPIPD+Q+++++ P
Sbjct: 242 IVDMFSDIDNKNVEVPKWPAHPFTDEHFKTKWFIVPIKDIRNLNITFPIPDMQEHFRAAP 301
Query: 331 GHYLGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDI 390
HY HL+GHEG GSLLS LK KGW N+LV G++ ARGF FF + VDLTEEG+LHV+DI
Sbjct: 302 VHYWSHLLGHEGKGSLLSTLKEKGWCNSLVSGKRSSARGFDFFSVYVDLTEEGILHVDDI 361
Query: 391 ILHMFQYIQKLRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVL 450
+ FQYI L+ EGP EW+F+E D+ + FRFK+K PR Y + L YP+EEVL
Sbjct: 362 VTMTFQYINMLKNEGPVEWIFEEYSDIAKMNFRFKEKASPRSYVNVTVQSLQDYPIEEVL 421
Query: 451 TAEYLLEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVI 510
+A L ++RPDLI + + L PE +RV +V+K++E D E WYGT+YK+E IP+++I
Sbjct: 422 SASRLFTQWRPDLINELNNYLVPEKIRVQVVAKAYEANADSVEPWYGTKYKKEKIPEDLI 481
Query: 511 KKWQNADLNGKFKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLP 570
++W NA + F+LP KNEFIPT F+I +EK A +P +I+D + WFKQDD+F LP
Sbjct: 482 QRWNNAGTDEAFQLPEKNEFIPTKFDIKSIEK-AEKFPTIIEDNPFIRTWFKQDDEFLLP 540
Query: 571 KACLNFEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLS 630
KA + F+F SP Y+DP+ NM Y++++L +DSLNEYAY+A+LAGL ++L ++ YG+ L
Sbjct: 541 KATMTFDFVSPLTYIDPISSNMTYMFVQLFRDSLNEYAYSADLAGLKWELSHSKYGLSLI 600
Query: 631 VKGYNDKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLM 690
+ GY+ K +LL KI+++M F ID+KRF I+KE Y+R L NF AEQP+QHA YYL LM
Sbjct: 601 IAGYDHKLVVLLNKILDRMVNFTIDDKRFAILKENYIRGLKNFEAEQPYQHAAYYLAALM 660
Query: 691 TEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLI 750
+E W K+EL A +T R++ FIP L+S++HIE L+HGNITK AL ++ VE LI
Sbjct: 661 SEQVWVKNELLNACSMLTADRVRQFIPLLMSKMHIECLIHGNITKAEALKTVKNVESKLI 720
Query: 751 EHAHT-KPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLE 809
PLLP QLV YRE++LP+ ++Y+ N+ H + +IYYQ+ MQST NM LE
Sbjct: 721 SSVKDLTPLLPKQLVLYRELELPNGCHYLYEVDNKHHKSSCTQIYYQSGMQSTESNMLLE 780
Query: 810 LFCQIISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLIT 869
LF QIISEPCFN LRTKEQLGYIVFSG RR NG+QGLR I+QS K P ++E R++AF+ +
Sbjct: 781 LFTQIISEPCFNILRTKEQLGYIVFSGIRRTNGVQGLRIIVQSNKHPQFVEERIDAFMES 840
Query: 870 MEKSIEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLK 929
M+ I +M++E F +H ++LA +RL+KPK L+++ YW EI QQYNFDR N EVAYLK
Sbjct: 841 MKDYITNMSDEEFNRHKESLATQRLEKPKMLTSQSGIYWNEISMQQYNFDRANVEVAYLK 900
Query: 930 TLTKEDIIKFYKEMLAVDAPRRHKVSVHVLAREMDSCP---VVGEFPCQNDINLSQAPAL 986
T+++ II FYK+++ ++P+RHK+S+HV++ V P + + A
Sbjct: 901 TISRSQIIDFYKDVVHSESPQRHKLSIHVVSTAEGGAAAEDVTSSTPSAEETKKTLEQAE 960
Query: 987 PQPEVIQNMTEFKRGLPLFPLVKPHIN 1013
QP IQ++ +FK PL+PLVKP N
Sbjct: 961 QQPARIQDILQFKTSHPLYPLVKPFNN 987
>ref|NP_524182.2| Insulin degrading metalloproteinase CG5517-PA [Drosophila
melanogaster]
gb|AAF51584.2| CG5517-PA [Drosophila melanogaster]
Length = 1031
Score = 1102 bits (2851), Expect = 0.0, Method: Composition-based stats.
Identities = 459/1014 (45%), Positives = 664/1014 (65%), Gaps = 8/1014 (0%)
Query: 4 RLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPEDKRE 63
R + L ++ T R++ P QK K ++ N+I KS +D R+
Sbjct: 18 RRSSALRASISVTHRTIGTLIKPKMTIAESSQKSATRKPDSMEPILRLNNIEKSLQDTRD 77
Query: 64 YRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKKYPK 123
YRGL+L NG+KVLLISDP TD S+AAL V +G +SDP N+ GL+HFCEHMLFLGT+KYP
Sbjct: 78 YRGLQLENGLKVLLISDPNTDVSAAALSVQVGHMSDPTNLPGLAHFCEHMLFLGTEKYPH 137
Query: 124 ENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKDREV 183
EN Y+ +LS+ GSSNA T T Y+F V+ + L+GALDRFAQFF+ PLF S +RE+
Sbjct: 138 ENGYTTYLSQSGGSSNAATYPLMTKYHFHVAPDKLDGALDRFAQFFIAPLFTPSATEREI 197
Query: 184 NAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQELLK 243
NAV+SEHEKN+ +D WR+ Q+ + P H +SKFG+GNK TL P + IDVR ELLK
Sbjct: 198 NAVNSEHEKNLPSDLWRIKQVNRHLAKPDHAYSKFGSGNKTTLSEIPKSKNIDVRDELLK 257
Query: 244 FHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQLYK 303
FH +YS+N+M + V+G+ESLD+L +V++ FSE+ENKNV +P +P HP+ EE Q K
Sbjct: 258 FHKQWYSANIMCLAVIGKESLDELEGMVLEKFSEIENKNVKVPGWPRHPYAEERYGQKVK 317
Query: 304 IVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLVGGQ 363
IVPIKDIR+L ++F DL ++YKS P +YL HLIGHEG GS+LSEL+ GW N L+ G
Sbjct: 318 IVPIKDIRSLTISFTTDDLTQFYKSGPDNYLTHLIGHEGKGSILSELRRLGWCNDLMAGH 377
Query: 364 KEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAVAFR 423
+ GF FF I VDLT+EGL HV+DI+ +FQY++ LR EGP++W+F EC LN + FR
Sbjct: 378 QNTQNGFGFFDIVVDLTQEGLEHVDDIVKIVFQYLEMLRKEGPKKWIFDECVKLNEMRFR 437
Query: 424 FKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAIVSK 483
FK+KE+P + + +PLEEVL A YL E+RPDLI+ +LD+L P R+ IVS+
Sbjct: 438 FKEKEQPENLVTHAVSSMQIFPLEEVLIAPYLSNEWRPDLIKGLLDELVPSKSRIVIVSQ 497
Query: 484 SFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPLEKE 543
SFE D E +Y T+Y + + ++ W+N +LN KL N FIPTNF+I + +
Sbjct: 498 SFEPDCDLAEPYYKTKYGITRVAKDTVQSWENCELNENLKLALPNSFIPTNFDISDVPAD 557
Query: 544 ATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELLKDS 603
A +P +I DT + ++W KQD++F PKAC+ F+ +P AY+DPL+CN+ ++ + LLKD
Sbjct: 558 APKHPTIILDTPILRVWHKQDNQFNKPKACMTFDMSNPIAYLDPLNCNLNHMMVMLLKDQ 617
Query: 604 LNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFEIIK 663
LNEY Y AELA L + G+ +++G++DKQ +LL+K+++ + F IDEKRF+I+K
Sbjct: 618 LNEYLYDAELASLKLSVMGKSCGIDFTIRGFSDKQVVLLEKLLDHLFDFSIDEKRFDILK 677
Query: 664 EAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRL 723
E Y+RSL NF+AEQP+QH++YYL LL+TE AW EL +A++ VT R+ F + RL
Sbjct: 678 EEYVRSLKNFKAEQPYQHSIYYLALLLTENAWANMELLDAMELVTYDRVLNFAKEFFQRL 737
Query: 724 HIEALLHGNITKQAALGIMQMVEDTL-IEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQR 782
H E + GN+TKQ A I V L +A P+L Q+++ RE +L +++++
Sbjct: 738 HTECFIFGNVTKQQATDIAGRVNTRLEATNASKLPILARQMLKKREYKLLAGDSYLFEKE 797
Query: 783 NEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRANG 842
NE H + ++Y Q Q+ N+ + L Q++SEPC++ LRTKEQLGYIVFSG R+ NG
Sbjct: 798 NEFHKSSCAQLYLQCGAQTDHTNIMVNLVSQVLSEPCYDCLRTKEQLGYIVFSGVRKVNG 857
Query: 843 IQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKLSA 902
G+R I+QS K P Y+E R+E FL T + IEDM + F++H +ALA+++L+KPK +
Sbjct: 858 ANGIRIIVQSAKHPSYVEDRIENFLQTYLQVIEDMPLDEFERHKEALAVKKLEKPKTIFQ 917
Query: 903 ECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLARE 962
+ ++++GEI Q Y+F+R+ EVA L+ ++K D + ++K+ +A D R +SVH+++++
Sbjct: 918 QFSQFYGEIAMQTYHFEREEAEVAILRKISKADFVDYFKKFIAKDGEERRVLSVHIVSQQ 977
Query: 963 MDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMA 1016
D P + + + + I ++ FK L+P+ P ++ A
Sbjct: 978 TDENATSEAEPVE-------ITNMERHKPISDIVTFKSCKELYPIALPFLDIKA 1024
>gb|AAO74689.1| RE17458p [Drosophila melanogaster]
Length = 1031
Score = 1102 bits (2850), Expect = 0.0, Method: Composition-based stats.
Identities = 459/1014 (45%), Positives = 665/1014 (65%), Gaps = 8/1014 (0%)
Query: 4 RLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPEDKRE 63
R + L ++ T R++ P QK K ++ N+I KS +D R+
Sbjct: 18 RRSSALRASISVTHRTIGTLIKPKMTIAESSQKSATRKPDSMEPILRLNNIEKSLQDTRD 77
Query: 64 YRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKKYPK 123
YRGL+L NG+KVLLISDP TD S+AAL V +G +SDP N+ GL+HFCEHMLFLGT+KYP
Sbjct: 78 YRGLQLENGLKVLLISDPNTDVSAAALSVQVGHMSDPTNLPGLAHFCEHMLFLGTEKYPH 137
Query: 124 ENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKDREV 183
EN Y+ +LS+ GSSNA T T Y+F V+ + L+GALDRFAQFF+ PLF S +RE+
Sbjct: 138 ENGYTTYLSQSGGSSNAATYPLMTKYHFHVAPDKLDGALDRFAQFFIAPLFTPSATEREI 197
Query: 184 NAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQELLK 243
NAV+SEHEKN+ +D WR+ Q+++ P H +SKFG+GNK TL P + IDVR ELLK
Sbjct: 198 NAVNSEHEKNLPSDLWRIKQVDRHLAKPDHAYSKFGSGNKTTLSEIPKSKNIDVRDELLK 257
Query: 244 FHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQLYK 303
FH +YS+N+M + V+G+ESLD+L +V++ FSE+ENKNV +P +P HP+ EE Q K
Sbjct: 258 FHKQWYSANIMCLAVIGKESLDELEGMVLEKFSEIENKNVKVPGWPRHPYAEERYGQKVK 317
Query: 304 IVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLVGGQ 363
IVPIKDIR+L ++F DL ++YKS P +YL HLIGHEG GS+LSEL+ GW N L+ G
Sbjct: 318 IVPIKDIRSLTISFTTDDLTQFYKSGPDNYLTHLIGHEGKGSILSELRRLGWCNDLMAGH 377
Query: 364 KEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAVAFR 423
+ GF FF I VDLT+EGL HV+DI+ +FQY++ LR EGP++W+F EC LN + FR
Sbjct: 378 QNTQNGFGFFDIVVDLTQEGLEHVDDIVKIVFQYLEMLRKEGPKKWIFDECVKLNEMRFR 437
Query: 424 FKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAIVSK 483
FK+KE+P + + +PLEEVL A YL E+RPDLI+ +LD+L P R+ IVS+
Sbjct: 438 FKEKEQPENLVTHAVSSMQIFPLEEVLIAPYLSNEWRPDLIKGLLDELVPSKSRIVIVSQ 497
Query: 484 SFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPLEKE 543
SFE D E +Y T+Y + + ++ W+N +LN KL N FIPTNF+I + +
Sbjct: 498 SFEPDCDLAEPYYKTKYGITRVAKDTVQSWENCELNENLKLALPNSFIPTNFDISDVPAD 557
Query: 544 ATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELLKDS 603
A +P +I DT + ++W KQD++F PKAC+ F+ +P AY+DPL+CN+ ++ + LLKD
Sbjct: 558 APKHPTIILDTPILRVWHKQDNQFNKPKACMTFDMSNPIAYLDPLNCNLNHMMVMLLKDQ 617
Query: 604 LNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFEIIK 663
LNEY Y AELA L + G+ +++G++DKQ +LL+K+++ + F IDEKRF+I+K
Sbjct: 618 LNEYLYDAELASLKLSVMGKSCGIDFTIRGFSDKQVVLLEKLLDHLFDFSIDEKRFDILK 677
Query: 664 EAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRL 723
E Y+RSL NF+AEQP+QH++YYL LL+TE AW EL +A++ VT R+ F + RL
Sbjct: 678 EEYVRSLKNFKAEQPYQHSIYYLALLLTENAWANMELLDAMELVTYDRVLNFAKEFFQRL 737
Query: 724 HIEALLHGNITKQAALGIMQMVEDTL-IEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQR 782
H E + GN+TKQ A I V L +A P+L Q+++ RE +L +++++
Sbjct: 738 HTECFIFGNVTKQQATDIAGRVNTRLEATNASKLPILARQMLKKREYKLLAGDSYLFEKE 797
Query: 783 NEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRANG 842
NE H + ++Y Q Q+ N+ + L Q++SEPC++ LRTKEQLGYIVFSG R+ NG
Sbjct: 798 NEFHKSSCAQLYLQCGAQTDHTNIMVNLVSQVLSEPCYDCLRTKEQLGYIVFSGVRKVNG 857
Query: 843 IQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKLSA 902
G+R I+QS K P Y+E R+E FL T + IEDM + F++H +ALA+++L+KPK +
Sbjct: 858 ANGIRIIVQSAKHPSYVEDRIENFLQTYLQVIEDMPLDEFERHKEALAVKKLEKPKTIFQ 917
Query: 903 ECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLARE 962
+ ++++GEI Q Y+F+R+ EVA L+ ++K D + ++K+ +A D R +SVH+++++
Sbjct: 918 QFSQFYGEIAMQTYHFEREEAEVAILRKISKADFVDYFKKFIAKDGEERRVLSVHIVSQQ 977
Query: 963 MDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMA 1016
D P + + + + I ++ FK L+P+ P ++ A
Sbjct: 978 TDENATSEAEPVE-------ITNMERHKPISDIVTFKSCKELYPIALPFLDIKA 1024
>ref|XP_001629798.1| predicted protein [Nematostella vectensis]
gb|EDO37735.1| predicted protein [Nematostella vectensis]
Length = 947
Score = 1099 bits (2844), Expect = 0.0, Method: Composition-based stats.
Identities = 556/912 (60%), Positives = 707/912 (77%), Gaps = 16/912 (1%)
Query: 47 IKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGL 106
+K + I KSP+D R+YRGL L NG+KVLLI D +TDKS+AA+DVHIGSL+DP + GL
Sbjct: 4 VKEVHKDIPKSPQDDRDYRGLLLENGLKVLLIHDSSTDKSAAAMDVHIGSLTDPKELPGL 63
Query: 107 SHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFA 166
+HFCEHMLFLGT+KYP EN Y+QFL+E+ GSSNAFTSGEHTNY+FDV +E L ALDRFA
Sbjct: 64 AHFCEHMLFLGTEKYPGENAYTQFLTENGGSSNAFTSGEHTNYFFDVKYESLSNALDRFA 123
Query: 167 QFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTL 226
QFFLCPLF+ KDREVNAVDSE+ KN +ND WRL QL+K+T +P HP++KF TGNK TL
Sbjct: 124 QFFLCPLFNADAKDREVNAVDSENSKNRLNDMWRLNQLDKSTVDPSHPYNKFCTGNKLTL 183
Query: 227 ETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLP 286
+TRP ++GID R+ELLKFHS YYS+N+M++ V+GRESLD++T +VVKLFS V+NKNV +P
Sbjct: 184 DTRPKEKGIDTREELLKFHSLYYSANIMSLSVIGRESLDEMTEMVVKLFSPVQNKNVTIP 243
Query: 287 EFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSL 346
FPEHP+ E ++ L+K+VP+KD++NL + FPIPD+ KYY P HY+ HLIGHEG GSL
Sbjct: 244 TFPEHPYGAEQVQTLFKVVPVKDMKNLNLMFPIPDMSKYYHFKPSHYISHLIGHEGEGSL 303
Query: 347 LSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGP 406
LSELK+KGWVN LV G +GA+GFMFF+ N++LT EG H+ +I +FQY++ LR E P
Sbjct: 304 LSELKAKGWVNALVAGALDGAKGFMFFMCNMELTNEGQDHIFEISTSVFQYLEMLRREEP 363
Query: 407 QEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEM 466
EWVF+ECK L V FRF DKE PR Y +A LH + +++VL +LL FRPDLI+
Sbjct: 364 FEWVFEECKALAEVRFRFNDKETPRSYVCHLARSLHDFSIDDVLRGPHLLTSFRPDLIKQ 423
Query: 467 VLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPT 526
VLD L PE VR+ IVSK+FEGKTD+TEEWYGT+Y E I + IK W+N LN +P
Sbjct: 424 VLDNLVPEKVRITIVSKAFEGKTDKTEEWYGTEYSMERIDQQQIKDWKNVSLNAALTIPK 483
Query: 527 KNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVD 586
KNEFIPT+ +I P E D+ ++K+WFKQD F LPKAC+ FE SP AY+D
Sbjct: 484 KNEFIPTDLDIRPAPGE---------DSPLTKVWFKQDVTFLLPKACMLFEITSPLAYID 534
Query: 587 PLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKII 646
P HCNMAY++L+LLKDSLNEYAY AE+AG++Y+L NT+YG+++S++GYN KQ IL++KI+
Sbjct: 535 PCHCNMAYIFLQLLKDSLNEYAYDAEIAGVTYNLDNTMYGIFMSIRGYNHKQGILMEKIL 594
Query: 647 EKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDD 706
++M F++D RF +IKE Y + L NF+AEQPHQHA+YY L+ E+AW KDEL +AL++
Sbjct: 595 KRMTKFKVDPNRFRLIKERYEQGLRNFKAEQPHQHALYYTSYLLEELAWHKDELIDALEE 654
Query: 707 VTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRY 766
VT+ +L+AFIPQLL RLHIE LLHGN+T++ ALG++ +E E++ TKPLLP QL R+
Sbjct: 655 VTIEKLQAFIPQLLGRLHIECLLHGNVTEKEALGLVDTMESIFTENSGTKPLLPLQLRRH 714
Query: 767 REVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTK 826
RE+QLP N VH+N IEIYYQ D+Q T NM LELFCQ+I E CFN LRT+
Sbjct: 715 REIQLP-------HTVNHVHSNSSIEIYYQCDLQETRSNMLLELFCQVIHESCFNILRTQ 767
Query: 827 EQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHI 886
EQLGYIVFSGPRR NG QGLRFIIQS+K P L+SRVE FL ++ IE MT+E F+ HI
Sbjct: 768 EQLGYIVFSGPRRGNGAQGLRFIIQSDKEPSLLDSRVEVFLDKTKEMIESMTDEEFKNHI 827
Query: 887 QALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAV 946
ALA+RRLDKPKKL E K+WGEI+++QYNFDRDN EVA+L+TLTK+D++ FYK++L
Sbjct: 828 DALAVRRLDKPKKLRTETQKHWGEILTRQYNFDRDNVEVAFLRTLTKDDLLNFYKDLLEP 887
Query: 947 DAPRRHKVSVHV 958
APRRHK++VH+
Sbjct: 888 SAPRRHKLAVHI 899
>sp|P22817|IDE_DROME Insulin-degrading enzyme (Insulysin) (Insulinase) (Insulin protease)
Length = 990
Score = 1095 bits (2832), Expect = 0.0, Method: Composition-based stats.
Identities = 454/984 (46%), Positives = 654/984 (66%), Gaps = 8/984 (0%)
Query: 34 FQKKTYSKMNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVH 93
QK K ++ N+I KS +D R+YRGL+L NG+KVLLISDP TD S+AAL V
Sbjct: 7 SQKSATRKPDSMEPILRLNNIEKSLQDTRDYRGLQLENGLKVLLISDPNTDVSAAALSVQ 66
Query: 94 IGSLSDPPNIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDV 153
+G +SDP N+ GL+HFCEHMLFLGT+KYP EN Y+ +LS+ GSSNA T T Y+F V
Sbjct: 67 VGHMSDPTNLPGLAHFCEHMLFLGTEKYPHENGYTTYLSQSGGSSNAATYPLMTKYHFHV 126
Query: 154 SHEHLEGALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKH 213
+ + L+GALDRFAQFF+ PLF S +RE+NAV+SEHEKN+ +D WR+ Q+ + P H
Sbjct: 127 APDKLDGALDRFAQFFIAPLFTPSATEREINAVNSEHEKNLPSDLWRIKQVNRHLAKPDH 186
Query: 214 PFSKFGTGNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVK 273
+SKFG+GNK TL P + IDVR ELLKFH +YS+N+M + V+G+ESLD+L +V++
Sbjct: 187 AYSKFGSGNKTTLSEIPKSKNIDVRDELLKFHKQWYSANIMCLAVIGKESLDELEGMVLE 246
Query: 274 LFSEVENKNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHY 333
FSE+ENKNV +P +P HP+ EE Q KIVPIKDIR+L ++F DL ++YKS P +Y
Sbjct: 247 KFSEIENKNVKVPGWPRHPYAEERYGQKVKIVPIKDIRSLTISFTTDDLTQFYKSGPDNY 306
Query: 334 LGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILH 393
L HLIGHEG GS+LSEL+ GW N L+ G + GF FF I VDLT+EGL HV+DI+
Sbjct: 307 LTHLIGHEGKGSILSELRRLGWCNDLMAGHQNTQNGFGFFDIVVDLTQEGLEHVDDIVKI 366
Query: 394 MFQYIQKLRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAE 453
+FQY++ LR EGP++W+F EC LN + FRFK+KE+P + + +PLEEVL A
Sbjct: 367 VFQYLEMLRKEGPKKWIFDECVKLNEMRFRFKEKEQPENLVTHAVSSMQIFPLEEVLIAP 426
Query: 454 YLLEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKW 513
YL E+RPDLI+ +LD+L P R+ IVS+SFE D E +Y T+Y + + ++ W
Sbjct: 427 YLSNEWRPDLIKGLLDELVPSKSRIVIVSQSFEPDCDLAEPYYKTKYGITRVAKDTVQSW 486
Query: 514 QNADLNGKFKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKAC 573
+N +LN KL N FIPTNF+I + +A +P +I DT + ++W KQD++F PKAC
Sbjct: 487 ENCELNENLKLALPNSFIPTNFDISDVPADAPKHPTIILDTPILRVWHKQDNQFNKPKAC 546
Query: 574 LNFEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKG 633
+ F+ +P AY+DPL+CN+ ++ + LLKD LNEY Y AELA L + G+ +++G
Sbjct: 547 MTFDMSNPIAYLDPLNCNLNHMMVMLLKDQLNEYLYDAELASLKLSVMGKSCGIDFTIRG 606
Query: 634 YNDKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEV 693
++DKQ +LL+K+++ + F IDEKRF+I+KE Y+RSL NF+AEQP+QH++YYL LL+TE
Sbjct: 607 FSDKQVVLLEKLLDHLFDFSIDEKRFDILKEEYVRSLKNFKAEQPYQHSIYYLALLLTEN 666
Query: 694 AWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTL-IEH 752
AW EL +A++ VT R+ F + RLH E + GN+TKQ A I V L +
Sbjct: 667 AWANMELLDAMELVTYDRVLNFAKEFFQRLHTECFIFGNVTKQQATDIAGRVNTRLEATN 726
Query: 753 AHTKPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFC 812
A P+L Q+++ RE +L +++++ NE H + ++Y Q Q+ N+ + L
Sbjct: 727 ASKLPILARQMLKKREYKLLAGDSYLFEKENEFHKSSCAQLYLQCGAQTDHTNIMVNLVS 786
Query: 813 QIISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEK 872
Q++SEPC++ LRTKEQLGYIVFSG R+ NG G+R I+QS K P Y+E R+E FL T +
Sbjct: 787 QVLSEPCYDCLRTKEQLGYIVFSGVRKVNGANGIRIIVQSAKHPSYVEDRIENFLQTYLQ 846
Query: 873 SIEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLT 932
IEDM + F++H +ALA+++L+KPK + + ++++GEI Q Y+F+R+ EVA L+ ++
Sbjct: 847 VIEDMPLDEFERHKEALAVKKLEKPKTIFQQFSQFYGEIAMQTYHFEREEAEVAILRKIS 906
Query: 933 KEDIIKFYKEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVI 992
K D + ++K+ +A D R +SVH+++++ D P + + + + I
Sbjct: 907 KADFVDYFKKFIAKDGEERRVLSVHIVSQQTDENATSEAEPVE-------ITNMERHKPI 959
Query: 993 QNMTEFKRGLPLFPLVKPHINFMA 1016
++ FK L+P+ P ++ A
Sbjct: 960 SDIVTFKSCKELYPIALPFLDIKA 983
>gb|AAA28439.1| insulin-degrading enzyme
Length = 990
Score = 1089 bits (2818), Expect = 0.0, Method: Composition-based stats.
Identities = 451/984 (45%), Positives = 650/984 (66%), Gaps = 8/984 (0%)
Query: 34 FQKKTYSKMNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVH 93
QK K ++ N+I KS +D R+YRGL+L NG+KVLLISDP TD S+AAL V
Sbjct: 7 SQKSVTRKPDSMEPILRLNNIEKSLQDTRDYRGLQLENGLKVLLISDPNTDVSAAALSVQ 66
Query: 94 IGSLSDPPNIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDV 153
+G +SDP N+ GL+HFCEHMLFLGT+KYP EN Y+ +LS+ GSSNA T T Y+F V
Sbjct: 67 VGHMSDPTNLPGLAHFCEHMLFLGTEKYPHENGYTTYLSQSGGSSNAATYPLMTKYHFHV 126
Query: 154 SHEHLEGALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKH 213
+ + L+GALDRFAQFF+ PLF S +RE+NAV+SEHEKN+ +D WR+ Q+ + P H
Sbjct: 127 APDKLDGALDRFAQFFIAPLFTPSATEREINAVNSEHEKNLPSDLWRIKQVNRHLAKPDH 186
Query: 214 PFSKFGTGNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVK 273
+SKFG+GNK TL P + IDVR ELLKFH +YS+N+M + V+G+ESLD+L +V++
Sbjct: 187 AYSKFGSGNKTTLSEIPKSKNIDVRDELLKFHKQWYSANIMCLAVIGKESLDELEGMVLE 246
Query: 274 LFSEVENKNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHY 333
FSE+ENKNV +P +P HP+ EE Q KIVPIKDIR+L ++F DL ++YKS P +Y
Sbjct: 247 KFSEIENKNVKVPGWPRHPYAEERYGQKVKIVPIKDIRSLTISFTTDDLTQFYKSGPDNY 306
Query: 334 LGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILH 393
L HLIGHEG GS+LSEL+ GW N L+ G + GF FF I VDLT+EGL HV+DI+
Sbjct: 307 LTHLIGHEGKGSILSELRRLGWCNDLMAGHQNTQNGFGFFDIVVDLTQEGLEHVDDIVKI 366
Query: 394 MFQYIQKLRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAE 453
+FQY++ LR EGP++W+ EC LN + FRFK+KE + + +PLEEVL A
Sbjct: 367 VFQYLEMLRKEGPKKWILDECVKLNEMRFRFKEKEESENLVTHAVSSMKIFPLEEVLIAP 426
Query: 454 YLLEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKW 513
YL E+ PDLI+ +LD+L P R+ IVS+SFE D E +Y T+Y + + ++ W
Sbjct: 427 YLSNEWSPDLIKGLLDELVPSKSRIVIVSQSFEPDCDLAEPYYKTKYGITRVAKDTVQSW 486
Query: 514 QNADLNGKFKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKAC 573
+N +LN KL N FIPTNF+I + +A +P +I DT + ++W KQD++F PKAC
Sbjct: 487 ENCELNENLKLALPNSFIPTNFDISDVPADAPKHPTIILDTPILRVWHKQDNQFNKPKAC 546
Query: 574 LNFEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKG 633
+ F+ +P AY+DPL+CN+ ++ + LLKD LNEY Y AELA L + G+ +++G
Sbjct: 547 MTFDMSNPIAYLDPLNCNLNHMMVMLLKDQLNEYLYDAELASLKLSVMGKSCGIDFTIRG 606
Query: 634 YNDKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEV 693
++DKQ +LL+K+++ + F IDEKRF+I+KE Y+RSL NF+AEQP+QH++YYL LL+TE
Sbjct: 607 FSDKQVVLLEKLLDHLFDFSIDEKRFDILKEEYVRSLKNFKAEQPYQHSIYYLALLLTEN 666
Query: 694 AWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTL-IEH 752
AW EL +A++ VT R+ F + RLH E + GN+TKQ A I V L +
Sbjct: 667 AWANMELLDAMELVTYDRVLNFAKEFFQRLHTECFIFGNVTKQQATDIAGRVNTRLEATN 726
Query: 753 AHTKPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFC 812
A P+L Q+++ RE +L +++++ NE H + ++Y Q Q+ N+ + L
Sbjct: 727 ASKLPILARQMLKKREYKLLAGDSYLFEKENEFHKSSCAQLYLQCGAQTDHTNIMVNLVS 786
Query: 813 QIISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEK 872
Q++SEPC++ LRTKEQLGYIVFSG R+ NG G+R I+QS K P Y+E R+E FL T +
Sbjct: 787 QVLSEPCYDCLRTKEQLGYIVFSGVRKVNGANGIRIIVQSAKHPSYVEDRIENFLQTYLQ 846
Query: 873 SIEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLT 932
IEDM + F++H +ALA+++L+KPK + + ++++GEI Q Y+F+R+ EVA L+ ++
Sbjct: 847 VIEDMPLDEFERHKEALAVKKLEKPKTIFQQFSQFYGEIAMQTYHFEREEAEVAILRKIS 906
Query: 933 KEDIIKFYKEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVI 992
K D + ++K+ +A D R +SVH+++++ D P + + + + I
Sbjct: 907 KADFVDYFKKFIAKDGEERRVLSVHIVSQQTDENATSEAEPVE-------ITNMERHKPI 959
Query: 993 QNMTEFKRGLPLFPLVKPHINFMA 1016
++ FK L+P+ P ++ A
Sbjct: 960 SDIVTFKSCKELYPIALPFLDIKA 983
>ref|XP_311589.4| AGAP010351-PA [Anopheles gambiae str. PEST]
gb|EAA07246.4| AGAP010351-PA [Anopheles gambiae str. PEST]
Length = 1030
Score = 1082 bits (2799), Expect = 0.0, Method: Composition-based stats.
Identities = 451/992 (45%), Positives = 645/992 (65%), Gaps = 16/992 (1%)
Query: 28 PERLCGFQKKTYSKMNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSS 87
+L N +RI N ITKS +D R+YRGL L+NG+KV+LISDPTTD+S+
Sbjct: 43 KAQLSNASTSLPQSTANMPFERI-NTITKSVQDNRDYRGLRLSNGMKVILISDPTTDRSA 101
Query: 88 AALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHT 147
AAL V +G LSDP I GL+H CEHMLFLGT+KYPKE+EY+ FL H GSSNA T + T
Sbjct: 102 AALSVAVGHLSDPLQIPGLAHLCEHMLFLGTEKYPKEDEYTAFLKVHGGSSNAATCSDMT 161
Query: 148 NYYFDVSHEHLEGALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKA 207
YYFDV LE ALDRF+QFF+ PLF+E +RE+NAV+SEHEKN+ D WR+ Q+ KA
Sbjct: 162 KYYFDVIPSKLEDALDRFSQFFIAPLFNEEVTEREINAVNSEHEKNLSQDVWRVKQVNKA 221
Query: 208 TGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDL 267
HP+++FGTGNK TL P I+VR EL+ FH+ +YSSN+M++ V G+ESLDDL
Sbjct: 222 LCKSTHPYNQFGTGNKQTLSESPKLNSINVRNELMTFHNKWYSSNIMSLAVFGQESLDDL 281
Query: 268 TNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYK 327
LV+K FS++ENK V P +P+ P+ ++ L I+P+KD R+L ++F + DL++YYK
Sbjct: 282 EALVIKFFSQIENKQVVAPRWPDMPYGDDQLNTKTYIIPVKDTRSLTISFQMEDLEQYYK 341
Query: 328 SNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHV 387
+ P HY+ HLIGHEG GS+LSELK++GW N L+ G RGF F + VDLTE+G H+
Sbjct: 342 AGPEHYVSHLIGHEGKGSILSELKARGWCNKLISGYCSLGRGFGSFDVMVDLTEDGFNHI 401
Query: 388 EDIILHMFQYIQKLRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLE 447
+D + +FQYI LR + PQ+W+F+E +L + FRFKDKE P + + +H +PLE
Sbjct: 402 DDTVKLIFQYINMLRVKKPQKWIFEEYCNLCEMLFRFKDKEGPTTLVTNVVSSMHLFPLE 461
Query: 448 EVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPD 507
+VL A L+ E+RPDL+E ++ KL P+ R+ IV + E + E WYGT+Y I
Sbjct: 462 DVLVAHCLITEWRPDLVEDLISKLTPDKARLIIVGQKCESLANAEERWYGTKYGVYKIEP 521
Query: 508 EVIKKWQNADLNGKFKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKF 567
V++ W DLN LP N FIPT+FE+LP++ +P +I+DT + + WFKQD +F
Sbjct: 522 SVLEYWSTPDLNDNLSLPEPNPFIPTDFELLPIDSGIENFPIVIQDTPIIRTWFKQDVEF 581
Query: 568 FLPKACLNFEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGM 627
PKA ++F+F SP Y +PL+CN+ L+++LLKD LNE+ + A+LAGL + + NT G+
Sbjct: 582 LKPKALMSFDFNSPIVYSNPLNCNLTRLFVQLLKDHLNEFLFEADLAGLGFGVSNTTSGI 641
Query: 628 YLSVKGYNDKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLR 687
LS+ GY+ KQ ILL+K+++ M F+ID +RFEI+KE Y+R L N++ EQP+QHA+YYL
Sbjct: 642 SLSIGGYSHKQVILLEKVLDNMFNFKIDRRRFEILKEQYIRGLKNYQTEQPYQHAIYYLA 701
Query: 688 LLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVED 747
LL+TE AWT+ EL ++ +++ RL+ F+ QLLS++H+E ++GN+ K+ AL + ++VED
Sbjct: 702 LLLTEQAWTRQELLDSTQLLSIERLQLFLEQLLSQMHVECFIYGNVNKEKALLMTKLVED 761
Query: 748 TLIE-HAHTKPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENM 806
+ A PLL QL+ RE +L F+++ NE H + +E+Y Q Q
Sbjct: 762 KMKSTDAKLVPLLARQLLPKREYKLGTGESFLFEATNEFHKSSCMELYLQCGQQEPHST- 820
Query: 807 FLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAF 866
F+++ Q++SE C+ LRTKEQLGY+VF G R+ANGI GLR I+QS + P Y+E R+E F
Sbjct: 821 FVDILSQLLSEGCYTQLRTKEQLGYLVFCGSRKANGICGLRIIVQSPRHPSYVEERIENF 880
Query: 867 LITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVA 926
L +E+M E F +H +AL L+KPK+L + Y EI +QY+F+R + E
Sbjct: 881 LNNTLDYLENMAECEFNRHKEALVALLLEKPKRLVTQFNIYLQEISLRQYHFNRAHVEAE 940
Query: 927 YLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLAREMDSC---PVVGEFPCQNDINLSQA 983
L+TLTK+ +I +YKE + + +P R +SV V++ PV F +
Sbjct: 941 KLRTLTKQQVIDYYKEHIILGSPSRSTLSVRVISTASGGAENSPVAENFRTTKKDFI--- 997
Query: 984 PALPQPEVIQNMTEFKRGLPLFPLVKPHINFM 1015
+ ++ FK L+PL +P++ M
Sbjct: 998 -------RVTDLASFKSSRSLYPLAQPYMEIM 1022
>emb|CAO23586.1| unnamed protein product [Vitis vinifera]
Length = 965
Score = 1080 bits (2793), Expect = 0.0, Method: Composition-based stats.
Identities = 383/966 (39%), Positives = 553/966 (57%), Gaps = 16/966 (1%)
Query: 49 RIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSH 108
I K D REYR + L N ++VLLISDP TDK++A++ V +GS DP GL+H
Sbjct: 3 EAAAEIVKPRTDTREYRRIVLRNSLEVLLISDPDTDKAAASMSVSVGSFCDPEGFPGLAH 62
Query: 109 FCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQF 168
F EHMLF ++KYP E+ YS+++ EH GS+NAFTS EHTNYYFDV+ + E ALDRFAQF
Sbjct: 63 FLEHMLFYASEKYPLEDSYSKYIIEHGGSTNAFTSSEHTNYYFDVNSDCFEEALDRFAQF 122
Query: 169 FLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLET 228
F+ PL RE+ AVDSE++KN+++DAWR+ QL+K HP+ KF TGN TLE
Sbjct: 123 FVKPLMSADATTREIKAVDSENQKNLLSDAWRMCQLQKHISAEGHPYHKFSTGNWDTLEV 182
Query: 229 RPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEF 288
+P ++G+D R EL+KF+ +YS+NLM + V +ESLD + +LV F E++NK+ +
Sbjct: 183 KPKEKGLDTRHELIKFYEEHYSANLMHLVVYTKESLDKIQSLVEHKFQEIQNKDRSNFQI 242
Query: 289 PEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLS 348
P P EHL+ L K VPIK L V +PI YK P YLGHLIGHEG GSL
Sbjct: 243 PGQPCTSEHLQILVKTVPIKQGHKLRVIWPITPSIHNYKEGPCRYLGHLIGHEGEGSLFY 302
Query: 349 ELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQE 408
LK+ GW +L G+ + F FF + +DLTE G H++DI+ +F+YI L+ G +
Sbjct: 303 ILKTLGWATSLSAGEGDWTCEFSFFKVVIDLTEAGHEHMQDIVGLLFKYISLLQQTGVCK 362
Query: 409 WVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVL 468
W+F E + F ++DK P Y ++ + YP ++ L L +F PD+I+ VL
Sbjct: 363 WIFDELSAICETVFHYQDKIPPIDYVVNVSSNMELYPPKDWLVGSSLPSKFSPDVIQKVL 422
Query: 469 DKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKN 528
D+L P NVR+ SK+FEG TD E WYGT Y E I +I++W A N LP+ N
Sbjct: 423 DELAPNNVRIFWESKNFEGHTDMVEPWYGTAYSIEKITSSMIQQWMLAAPNEHLHLPSPN 482
Query: 529 EFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPL 588
FIPT+ + ++ E +P L++ ++ S LW+K D F PKA + +F PFA P
Sbjct: 483 VFIPTDLSLKDVQ-EKAKFPVLLRKSSYSTLWYKPDTMFSTPKAYVKIDFNCPFASSSPE 541
Query: 589 HCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEK 648
+ ++ LL D LNEYAY A++AGL Y + +T G ++V GYN K ILL+ ++EK
Sbjct: 542 ADVLTDIFTRLLMDYLNEYAYYAQVAGLYYGINHTDSGFQVAVTGYNHKLRILLETVVEK 601
Query: 649 MATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVT 708
+A F++ RF +IKE + NF+ +QP+Q AMYY L++ + W + E + +
Sbjct: 602 IANFKVKPDRFLVIKEMVTKEYQNFKFQQPYQQAMYYCSLILQDNTWPWMDGLEVIPHLE 661
Query: 709 LPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAH--TKPLLPSQLVRY 766
L F+P LLSR ++ + GNI + A ++ +ED H ++PL PSQ +
Sbjct: 662 ADDLAKFVPMLLSRAFLDCYIAGNIEPKEAESMIHHIEDIFYSGPHPISQPLFPSQYLTN 721
Query: 767 REVQLPDRGWFVY--QQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLR 824
R ++L + Y + N N + Y Q N+ L+LF I + F+ LR
Sbjct: 722 RVIKLDRGMSYFYPAEGLNPSDENSALVHYIQVHRDDFLPNVKLQLFALIAKQRAFHQLR 781
Query: 825 TKEQLGYIVFSGPRRANGIQGLRFIIQSE-KPPHYLESRVEAFLITMEKSIEDMTEEAFQ 883
+ EQLGYI R +GI+G++FIIQS K P +++SRV FL E + M+E+ F+
Sbjct: 782 SVEQLGYITVLMQRNDSGIRGVQFIIQSTVKGPGHIDSRVVEFLKMFESKLYAMSEDEFK 841
Query: 884 KHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEM 943
++ AL +L+K K L E YW EI FDR EVA LK LT++++I F+ E
Sbjct: 842 SNVNALIDMKLEKHKNLREESGFYWREIYDGTLKFDRREAEVAALKKLTQKELIDFFNEH 901
Query: 944 LAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLP 1003
+ V AP++ +SV V G + +A P+ I ++ +F++ P
Sbjct: 902 IKVGAPQKKTLSVRVYG---------GLHTSEYADEKKEANQ-PKQVKIDDIFKFRKSQP 951
Query: 1004 LFPLVK 1009
L+ K
Sbjct: 952 LYGSFK 957
>ref|XP_748141.1| a-pheromone processing metallopeptidase Ste23 [Aspergillus fumigatus
Af293]
gb|EAL86103.1| a-pheromone processing metallopeptidase Ste23 [Aspergillus fumigatus
Af293]
Length = 1154
Score = 1078 bits (2788), Expect = 0.0, Method: Composition-based stats.
Identities = 385/950 (40%), Positives = 580/950 (61%), Gaps = 16/950 (1%)
Query: 42 MNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPP 101
+ +I+RI H+ K D R YR + L+N ++ LL+ DP TDK+SA+++V++G+ SD
Sbjct: 79 VTMGSIQRITEHLEKPELDDRSYRVIRLSNKLEALLVHDPETDKASASVNVNVGNFSDAD 138
Query: 102 NIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGA 161
++ G++H EH+LF+GTKK+PKEN Y+Q+L+ H+GSSNA+T+ TNY+F+ L GA
Sbjct: 139 DMPGMAHAVEHLLFMGTKKFPKENAYNQYLASHSGSSNAYTAATETNYFFE-PSSPLYGA 197
Query: 162 LDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTG 221
LDRFAQFF+ PLF ES DRE+ AVDSE++KN+ +D WRL QL K+ NP HP+ F TG
Sbjct: 198 LDRFAQFFVSPLFLESTLDRELRAVDSENKKNLQSDLWRLMQLNKSLSNPAHPYHHFSTG 257
Query: 222 NKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENK 281
N TL+ P Q G++VR E +KF+ +YS+N M +CVLGRESLD+L V +LFSEVENK
Sbjct: 258 NLKTLKEDPQQRGLEVRSEFIKFYQKHYSANRMKLCVLGRESLDELEKWVEELFSEVENK 317
Query: 282 NVPLPEFPE-HPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGH 340
++P + + P++ E L P+ D R+L + FP D + Y+S P Y+ HLIGH
Sbjct: 318 DLPQNRWDDVQPWRHEDLGIQIFAKPVMDTRSLDIYFPFLDEETLYESQPSRYISHLIGH 377
Query: 341 EGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQK 400
EGPGS+L+ +K+KGW N L G G F I++ LT+EGL ++ +FQYI
Sbjct: 378 EGPGSILAYIKAKGWANGLSAGVMPICPGAAAFTISIRLTKEGLQQYREVAKVVFQYIAM 437
Query: 401 LRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFR 460
L+ PQ+WVF E K++ V FRFK K +TS+++ ++ E L + LL +F
Sbjct: 438 LKEREPQQWVFDEMKNMAEVEFRFKQKSPASRFTSRLSSVMQKPLPREWLLSGSLLRKFD 497
Query: 461 PDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNA---- 516
PDLI+ L LRP+N R+ +VS+ + G D E+WYGT+YK IP++ + + A
Sbjct: 498 PDLIKKALSYLRPDNFRLIVVSQEYPGDWDSKEKWYGTEYKVGKIPEDFMADIREALDTT 557
Query: 517 --DLNGKFKLPTKNEFIPTNFEILPLE-KEATPYPALIKDTAMSKLWFKQDDKFFLPKAC 573
+P KNEF+PT + E E P LI+ +LWFK+DD+F++PK
Sbjct: 558 PETRLSDLHMPHKNEFVPTRLSVEKKEVSEPAKTPKLIRHDDHVRLWFKKDDRFWVPKGT 617
Query: 574 LNFEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKG 633
++ +P A+ P + + LY EL+KD+L EY+Y AELAGL Y L +++G+ +SV G
Sbjct: 618 VHITLRNPLAWATPANLVKSKLYCELVKDALVEYSYDAELAGLDYHLSASVFGLDVSVGG 677
Query: 634 YNDKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEV 693
YNDK +LL+K+ M ++ RF IIKE R N +QP Y R L +E
Sbjct: 678 YNDKMAVLLEKVFTSMRDLVVNPNRFHIIKERLSRGYRNAEYQQPFYQVGDYTRYLTSEK 737
Query: 694 AWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHA 753
W ++ L+ + + +F PQLLS+ HIE L HGN+ K+ AL + +VE+ L
Sbjct: 738 TWINEQYAAELEHIEAEDISSFFPQLLSQNHIEVLAHGNLYKEDALKMTDLVENIL---- 793
Query: 754 HTKPLLPSQLVRYREVQLPDRGWFVYQQ--RNEVHNNCGIEIY-YQTDMQSTSENMFLEL 810
++PL SQ R + +P F+Y++ R+ + N IE Y Y + L L
Sbjct: 794 QSRPLPQSQWHVRRNIIIPPGSNFIYERTLRDPANINHCIEYYVYVGSITDDMLRAKLLL 853
Query: 811 FCQIISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITM 870
F Q+ EP F+ LR+KEQLGY+V+SG R + G R IIQSE+ YLESR++ FLI
Sbjct: 854 FAQMTDEPAFDQLRSKEQLGYVVWSGARYSATTIGYRVIIQSERTAEYLESRIDNFLIQT 913
Query: 871 EKSIEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKT 930
+++E+M+E+ F+ H +++ +RL+K K LS+E +++W I S+ ++F ++ ++ A ++
Sbjct: 914 GETLENMSEKDFEGHKRSVINKRLEKLKNLSSETSRFWSHIGSEYFDFLQNESDAANVRA 973
Query: 931 LTKEDIIKFYKEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINL 980
LTK DI+ FYK+++ +P R K+S+++ A+ + G+ ++L
Sbjct: 974 LTKADIVDFYKQLIDPRSPTRGKLSIYLNAQGGAHAKLEGKDQQSRLVSL 1023
>ref|XP_001266332.1| a-pheromone processing metallopeptidase Ste23 [Neosartorya fischeri
NRRL 181]
gb|EAW24435.1| a-pheromone processing metallopeptidase Ste23 [Neosartorya fischeri
NRRL 181]
Length = 1155
Score = 1077 bits (2785), Expect = 0.0, Method: Composition-based stats.
Identities = 393/1003 (39%), Positives = 597/1003 (59%), Gaps = 33/1003 (3%)
Query: 6 AWLLHPALPSTFRSVLGARLPPPERLCG-------FQKKTYSK----------MNNPAIK 48
++ L P++ ST + + P C + +++ S+ + +I+
Sbjct: 27 SFSLVPSIASTAIAPHFSSSPRRRLNCPQSLLSRCWSRRSLSRSTVAPFSAAAVTMGSIQ 86
Query: 49 RIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSH 108
I H+ K D R YR + L+N ++ LL+ DP TDK+SA+++V++G+ SD ++ G++H
Sbjct: 87 HITEHLEKPELDDRSYRVIRLSNKLEALLVHDPETDKASASVNVNVGNFSDADDMPGMAH 146
Query: 109 FCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQF 168
EH+LF+GTKK+PKEN Y+Q+L+ H+GSSNA+T+ TNY+F+ L GALDRFAQF
Sbjct: 147 AVEHLLFMGTKKFPKENAYNQYLASHSGSSNAYTAATETNYFFE-PSSPLYGALDRFAQF 205
Query: 169 FLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLET 228
F+ PLF ES DRE+ AVDSE++KN+ +D WRL QL K+ NP HP+ F TGN TL+
Sbjct: 206 FVSPLFLESTLDRELRAVDSENKKNLQSDLWRLMQLNKSLSNPAHPYHHFSTGNLKTLKE 265
Query: 229 RPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEF 288
P Q G++VR E +KF+ +YS+N M +CVLGRESLD+L V +LFSEVENK++P +
Sbjct: 266 DPQQRGLEVRSEFIKFYQKHYSANRMRLCVLGRESLDELEKWVEELFSEVENKDLPQNRW 325
Query: 289 PE-HPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLL 347
+ P+++E L P+ D R+L + FP D + Y+S P Y+ HLIGHEGPGS+L
Sbjct: 326 DDVQPWRDEDLGIQIFAKPVMDTRSLDIYFPFLDEETLYESQPSRYISHLIGHEGPGSIL 385
Query: 348 SELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQ 407
+ +K+KGW N L G G F I++ LT+EGL ++ +FQYI L+ PQ
Sbjct: 386 AYIKAKGWANGLSAGVMPICPGAAAFTISIRLTKEGLQQYREVAKVVFQYIAMLKEREPQ 445
Query: 408 EWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMV 467
+WVF E K+L V FRFK K +TS+++ ++ E L + LL +F PDLI+
Sbjct: 446 QWVFDEMKNLAEVEFRFKQKSPASRFTSRLSSVMQKPLPREWLLSGSLLRKFDPDLIKKA 505
Query: 468 LDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNA------DLNGK 521
L LRP+N R+ +VS+ + G + E+WYGT+YK IP + + + A +
Sbjct: 506 LSYLRPDNFRLIVVSQEYPGDWNSKEKWYGTEYKVGKIPQDFMADIREALDSTPETRLSE 565
Query: 522 FKLPTKNEFIPTNFEILPLE-KEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFS 580
+P KNEF+PT + E E P LI+ +LWFK+DD+F++PK ++ +
Sbjct: 566 LHMPHKNEFVPTRLSVEKKEVAEPAKTPKLIRHDDHVRLWFKKDDRFWVPKGTVHITLRN 625
Query: 581 PFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPI 640
P A+ P + + LY EL+KD+L EY+Y AELAGL Y L +++G+ +SV GYNDK +
Sbjct: 626 PLAWATPANLVKSKLYCELVKDALVEYSYDAELAGLDYHLSASVFGLDVSVGGYNDKMAV 685
Query: 641 LLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDEL 700
LL+K+ M ++ RF IIKE R N +QP Y R L +E W ++
Sbjct: 686 LLEKVFTSMRDLVVNPNRFHIIKERLSRGYRNAEYQQPFYQVGDYTRYLTSEKTWINEQY 745
Query: 701 KEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLP 760
L+ + + F PQLLS+ HIE L HGN+ K+ AL + +VE+ L ++PL
Sbjct: 746 AAELEHIDAEDISNFFPQLLSQNHIEVLAHGNLYKEDALKMTDLVENIL----QSRPLPQ 801
Query: 761 SQLVRYREVQLPDRGWFVYQQ--RNEVHNNCGIEIY-YQTDMQSTSENMFLELFCQIISE 817
SQ R + +P +VY++ R+ + N IE Y Y + L LF Q+ E
Sbjct: 802 SQWHVRRNIIIPPGSNYVYERTLRDPANINHCIEYYVYVGSITDDMLRAKLLLFAQMTDE 861
Query: 818 PCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDM 877
P F+ LR+KEQLGY+V+SG R + G R IIQSE+ YLESR++ FLI +++E+M
Sbjct: 862 PAFDQLRSKEQLGYVVWSGARYSATTIGYRVIIQSERTAEYLESRIDNFLIQTGETLENM 921
Query: 878 TEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDII 937
+E+ F+ H +++ +RL+K K LS+E +++W I S+ ++F ++ ++ A ++ LTK DI+
Sbjct: 922 SEKDFEGHKRSVINKRLEKLKNLSSETSRFWSHIGSEYFDFLQNESDAANVRALTKADIV 981
Query: 938 KFYKEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINL 980
FYK++L +P R K+S+++ A+ V G+ ++L
Sbjct: 982 DFYKQLLDPRSPTRGKLSIYLNAQGGAHAKVEGKDQQSRLVSL 1024
>gb|EDP51051.1| a-pheromone processing metallopeptidase Ste23 [Aspergillus fumigatus
A1163]
Length = 1154
Score = 1077 bits (2785), Expect = 0.0, Method: Composition-based stats.
Identities = 385/950 (40%), Positives = 580/950 (61%), Gaps = 16/950 (1%)
Query: 42 MNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPP 101
+ +I+RI H+ K D R YR + L+N ++ LL+ DP TDK+SA+++V++G+ SD
Sbjct: 79 VTMGSIQRITEHLEKPELDDRSYRVIRLSNKLEALLVHDPETDKASASVNVNVGNFSDAD 138
Query: 102 NIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGA 161
++ G++H EH+LF+GTKK+PKEN Y+Q+L+ H+GSSNA+T+ TNY+F+ L GA
Sbjct: 139 DMPGMAHAVEHLLFMGTKKFPKENAYNQYLASHSGSSNAYTAATETNYFFE-PSSPLYGA 197
Query: 162 LDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTG 221
LDRFAQFF+ PLF ES DRE+ AVDSE++KN+ +D WRL QL K+ NP HP+ F TG
Sbjct: 198 LDRFAQFFVSPLFLESTLDRELRAVDSENKKNLQSDLWRLMQLNKSLSNPAHPYHHFSTG 257
Query: 222 NKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENK 281
N TL+ P Q G++VR E +KF+ +YS+N M +CVLGRESLD+L V +LFSEVENK
Sbjct: 258 NLKTLKEDPQQRGLEVRSEFIKFYQKHYSANRMKLCVLGRESLDELEKWVEELFSEVENK 317
Query: 282 NVPLPEFPE-HPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGH 340
++P + + P++ E L P+ D R++ + FP D + Y+S P Y+ HLIGH
Sbjct: 318 DLPQNRWDDVQPWRHEDLGIQIFAKPVMDTRSVDIYFPFLDEETLYESQPSRYISHLIGH 377
Query: 341 EGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQK 400
EGPGS+L+ +K+KGW N L G G F I++ LT+EGL ++ +FQYI
Sbjct: 378 EGPGSILAYIKAKGWANGLSAGVMPICPGAAAFTISIRLTKEGLQQYREVAKVVFQYIAM 437
Query: 401 LRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFR 460
L+ PQ+WVF E K+L V FRFK K +TS+++ ++ E L + LL +F
Sbjct: 438 LKEREPQQWVFDEMKNLAEVEFRFKQKSPASRFTSRLSSVMQKPLPREWLLSGSLLRKFD 497
Query: 461 PDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNA---- 516
PDLI+ L LRP+N R+ +VS+ + G D E+WYGT+YK IP++ + + A
Sbjct: 498 PDLIKKALSYLRPDNFRLIVVSQEYPGDWDSKEKWYGTEYKVGKIPEDFMADIREALDTT 557
Query: 517 --DLNGKFKLPTKNEFIPTNFEILPLE-KEATPYPALIKDTAMSKLWFKQDDKFFLPKAC 573
+P KNEF+PT + E E P LI+ +LWFK+DD+F++PK
Sbjct: 558 PETRLSDLHMPHKNEFVPTRLSVEKKEVSEPAKTPKLIRHDDHVRLWFKKDDRFWVPKGT 617
Query: 574 LNFEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKG 633
++ +P A+ P + + LY EL+KD+L EY+Y AELAGL Y L +++G+ +SV G
Sbjct: 618 VHITLRNPLAWATPANLVKSKLYCELVKDALVEYSYDAELAGLDYHLSASVFGLDVSVGG 677
Query: 634 YNDKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEV 693
YNDK +LL+K+ M ++ RF IIKE R N +QP Y R L +E
Sbjct: 678 YNDKMAVLLEKVFTSMRDLVVNPNRFHIIKERLSRGYRNAEYQQPFYQVGDYTRYLTSEK 737
Query: 694 AWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHA 753
W ++ L+ + + +F PQLLS+ HIE L HGN+ K+ AL + +VE+ L
Sbjct: 738 TWINEQYAAELEHIEAEDISSFFPQLLSQNHIEVLAHGNLYKEDALKMTDLVENIL---- 793
Query: 754 HTKPLLPSQLVRYREVQLPDRGWFVYQQ--RNEVHNNCGIEIY-YQTDMQSTSENMFLEL 810
++PL SQ R + +P F+Y++ R+ + N IE Y Y + L L
Sbjct: 794 QSRPLPQSQWHVRRNIIIPPGSNFIYERTLRDPANINHCIEYYVYVGSITDDMLRAKLLL 853
Query: 811 FCQIISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITM 870
F Q+ EP F+ LR+KEQLGY+V+SG R + G R IIQSE+ YLESR++ FLI
Sbjct: 854 FAQMTDEPAFDQLRSKEQLGYVVWSGARYSATTIGYRVIIQSERTAEYLESRIDNFLIQT 913
Query: 871 EKSIEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKT 930
+++E+M+E+ F+ H +++ +RL+K K LS+E +++W I S+ ++F ++ ++ A ++
Sbjct: 914 GETLENMSEKDFEGHKRSVINKRLEKLKNLSSETSRFWSHIGSEYFDFLQNESDAANVRA 973
Query: 931 LTKEDIIKFYKEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINL 980
LTK DI+ FYK+++ +P R K+S+++ A+ + G+ ++L
Sbjct: 974 LTKADIVDFYKQLIDPRSPTRGKLSIYLNAQGGAHTKLEGKDQQSRLVSL 1023
>ref|NP_181710.1| peptidase M16 family protein / insulinase family protein [Arabidopsis
thaliana]
gb|AAC02769.1| putative zinc protease [Arabidopsis thaliana]
Length = 970
Score = 1075 bits (2781), Expect = 0.0, Method: Composition-based stats.
Identities = 367/962 (38%), Positives = 545/962 (56%), Gaps = 19/962 (1%)
Query: 53 HITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEH 112
I K D REYR + L N ++VLLISDP TDK +A++ V +GS SDP + GL+HF EH
Sbjct: 14 EILKPRTDNREYRMIVLKNLLQVLLISDPDTDKCAASMSVSVGSFSDPQGLEGLAHFLEH 73
Query: 113 MLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCP 172
MLF ++KYP+E+ YS++++EH GS+NA+T+ E TNY+FDV+ + + ALDRFAQFF+ P
Sbjct: 74 MLFYASEKYPEEDSYSKYITEHGGSTNAYTASEETNYHFDVNADCFDEALDRFAQFFIKP 133
Query: 173 LFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQ 232
L RE+ AVDSE++KN+++D WR+ QL+K HP+ KF TGN TL RP
Sbjct: 134 LMSADATMREIKAVDSENQKNLLSDGWRIRQLQKHLSKEDHPYHKFSTGNMDTLHVRPQA 193
Query: 233 EGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHP 292
+G+D R EL+KF+ +YS+N+M + V G+ESLD + +LV ++F E++N N +P FP P
Sbjct: 194 KGVDTRSELIKFYEEHYSANIMHLVVYGKESLDKIQDLVERMFQEIQNTNKVVPRFPGQP 253
Query: 293 FQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKS 352
+HL+ L K +PIK L V++P+ +Y P YLGHLIGHEG GSL LK+
Sbjct: 254 CTADHLQILVKAIPIKQGHKLGVSWPVTPSIHHYDEAPSQYLGHLIGHEGEGSLFHALKT 313
Query: 353 KGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQ 412
GW L G+ E + FF +++DLT+ G H+++I+ +F YIQ L+ G +W+F
Sbjct: 314 LGWATGLSAGEGEWTLDYSFFKVSIDLTDAGHEHMQEILGLLFNYIQLLQQTGVCQWIFD 373
Query: 413 ECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLR 472
E + F ++DK P Y IA + YP ++ L L +F P +++ V+D+L
Sbjct: 374 ELSAICETKFHYQDKIPPMSYIVDIASNMQIYPTKDWLVGSSLPTKFNPAIVQKVVDELS 433
Query: 473 PENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIP 532
P N R+ S+ FEG+TD+ E WY T Y E I I++W + + LP N FIP
Sbjct: 434 PSNFRIFWESQKFEGQTDKAEPWYNTAYSLEKITSSTIQEWVQSAPDVHLHLPAPNVFIP 493
Query: 533 TNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNM 592
T+ + + + T P L++ T S+LW+K D F PKA + +F P A P +
Sbjct: 494 TDLSLKDADDKET-VPVLLRKTPFSRLWYKPDTMFSKPKAYVKMDFNCPLAVSSPDAAVL 552
Query: 593 AYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATF 652
++ LL D LNEYAY A++AGL Y + + G L++ GYN K ILL+ ++ K+A F
Sbjct: 553 TDIFTRLLMDYLNEYAYYAQVAGLYYGVSLSDNGFELTLLGYNHKLRILLETVVGKIANF 612
Query: 653 EIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRL 712
E+ RF +IKE + N++ QP+ AMYY L++ + W E + L + +
Sbjct: 613 EVKPDRFAVIKETVTKEYQNYKFRQPYHQAMYYCSLILQDQTWPWTEELDVLSHLEAEDV 672
Query: 713 KAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAH--TKPLLPSQLVRYREVQ 770
F+P LLSR IE + GN+ A +++ +ED L +PL PSQ + R V+
Sbjct: 673 AKFVPMLLSRTFIECYIAGNVENNEAESMVKHIEDVLFNDPKPICRPLFPSQHLTNRVVK 732
Query: 771 LPDRGWFVYQQR--NEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQ 828
L + + Y Q N N + Y Q S N+ L+LF + + F+ LRT EQ
Sbjct: 733 LGEGMKYFYHQDGSNPSDENSALVHYIQVHRDDFSMNIKLQLFGLVAKQATFHQLRTVEQ 792
Query: 829 LGYIVFSGPRRANGIQGLRFIIQSE-KPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQ 887
LGYI R +GI G++FIIQS K P +++SRVE+ L E + +M+ E F+ ++
Sbjct: 793 LGYITALAQRNDSGIYGVQFIIQSSVKGPGHIDSRVESLLKNFESKLYEMSNEDFKSNVT 852
Query: 888 ALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVD 947
AL +L+K K L E YW EI S F+R EV+ LK L K+++I F+ E + V
Sbjct: 853 ALIDMKLEKHKNLKEESRFYWREIQSGTLKFNRKEAEVSALKQLQKQELIDFFDEYIKVG 912
Query: 948 APRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEV-IQNMTEFKRGLPLFP 1006
A R+ +S+ V + + +P P V I+++ F++ PL
Sbjct: 913 AARKKSLSIRVYGSQHLKEMASDK------------DEVPSPSVEIEDIVGFRKSQPLHG 960
Query: 1007 LV 1008
Sbjct: 961 SF 962
>dbj|BAE98754.1| putative zinc protease [Arabidopsis thaliana]
Length = 970
Score = 1074 bits (2779), Expect = 0.0, Method: Composition-based stats.
Identities = 367/962 (38%), Positives = 545/962 (56%), Gaps = 19/962 (1%)
Query: 53 HITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEH 112
I K D REYR + L N ++VLLISDP TDK +A++ V +GS SDP + GL+HF EH
Sbjct: 14 EILKPRTDNREYRMIVLKNLLQVLLISDPDTDKCAASMSVSVGSFSDPQGLEGLAHFLEH 73
Query: 113 MLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCP 172
MLF ++KYP+E+ YS++++EH GS+NA+T+ E TNY+FDV+ + + ALDRFAQFF+ P
Sbjct: 74 MLFYASEKYPEEDSYSKYITEHGGSTNAYTASEETNYHFDVNADCFDEALDRFAQFFIKP 133
Query: 173 LFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQ 232
L RE+ AVDSE++KN+++D WR+ QL+K HP+ KF TGN TL RP
Sbjct: 134 LMSADATMREIKAVDSENQKNLLSDGWRIRQLQKHLSKEDHPYHKFSTGNMDTLHVRPQA 193
Query: 233 EGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHP 292
+G+D R EL+KF+ +YS+N+M + V G+ESLD + +LV ++F E++N N +P FP P
Sbjct: 194 KGVDTRSELIKFYEEHYSANIMHLVVYGKESLDKIQDLVERMFQEIQNTNKVVPRFPGQP 253
Query: 293 FQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKS 352
+HL+ L K +PIK L V++P+ +Y P YLGHLIGHEG GSL LK+
Sbjct: 254 CTADHLQILVKAIPIKQGHKLGVSWPVTPSIHHYDEAPSQYLGHLIGHEGEGSLFHALKT 313
Query: 353 KGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQ 412
GW L G+ E + FF +++DLT+ G H+++I+ +F YIQ L+ G +W+F
Sbjct: 314 LGWATGLSAGEGEWTLDYSFFKVSIDLTDAGHEHMQEILGLLFNYIQLLQQTGVCQWIFD 373
Query: 413 ECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLR 472
E + F ++DK P Y IA + YP ++ L L +F P +++ V+D+L
Sbjct: 374 ELSAICETKFHYQDKIPPMSYIVDIASNMQIYPTKDWLVGSSLPTKFNPAIVQKVVDELS 433
Query: 473 PENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIP 532
P N R+ S+ FEG+TD+ E WY T Y E I I++W + + LP N FIP
Sbjct: 434 PSNFRIFWESQKFEGQTDKAEPWYNTAYSLEKITSSTIQEWVQSAPDVHLHLPAPNVFIP 493
Query: 533 TNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNM 592
T+ + + + T P L++ T S+LW+K D F PKA + +F P A P +
Sbjct: 494 TDLSLKDADDKET-VPVLLRKTPFSRLWYKPDTMFSKPKAYVKMDFNCPLAVSSPDAAVL 552
Query: 593 AYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATF 652
++ LL D LNEYAY A++AGL Y + + G L++ GYN K ILL+ ++ K+A F
Sbjct: 553 TDIFTRLLMDYLNEYAYYAQVAGLYYGVSLSDNGFELTLLGYNHKLRILLETVVGKIANF 612
Query: 653 EIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRL 712
E+ RF +IKE + N++ QP+ AMYY L++ + W E + L + +
Sbjct: 613 EVKPDRFAVIKETVTKEYQNYKFRQPYHQAMYYCSLILQDQTWPWTEELDVLSHLEAEDV 672
Query: 713 KAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAH--TKPLLPSQLVRYREVQ 770
F+P LLSR IE + GN+ A +++ +ED L +PL PSQ + R V+
Sbjct: 673 AKFVPMLLSRTFIECYIAGNVENNEAESMVKHIEDVLFNDPKPICRPLFPSQRLTNRVVK 732
Query: 771 LPDRGWFVYQQR--NEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQ 828
L + + Y Q N N + Y Q S N+ L+LF + + F+ LRT EQ
Sbjct: 733 LGEGMKYFYHQDGSNPSDENSALVHYIQVHRDDFSMNIKLQLFGLVAKQATFHQLRTVEQ 792
Query: 829 LGYIVFSGPRRANGIQGLRFIIQSE-KPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQ 887
LGYI R +GI G++FIIQS K P +++SRVE+ L E + +M+ E F+ ++
Sbjct: 793 LGYITALAQRNDSGIYGVQFIIQSSVKGPGHIDSRVESLLKNFESKLYEMSNEDFKSNVT 852
Query: 888 ALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVD 947
AL +L+K K L E YW EI S F+R EV+ LK L K+++I F+ E + V
Sbjct: 853 ALIDMKLEKHKNLKEESRFYWREIQSGTLKFNRKEAEVSALKQLQKQELIDFFDEYIKVG 912
Query: 948 APRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEV-IQNMTEFKRGLPLFP 1006
A R+ +S+ V + + +P P V I+++ F++ PL
Sbjct: 913 AARKKSLSIRVYGSQHLKEMASDK------------DEVPSPSVEIEDIVGFRKSQPLHG 960
Query: 1007 LV 1008
Sbjct: 961 SF 962
>ref|XP_001276340.1| a-pheromone processing metallopeptidase Ste23 [Aspergillus clavatus
NRRL 1]
gb|EAW14914.1| a-pheromone processing metallopeptidase Ste23 [Aspergillus clavatus
NRRL 1]
Length = 1156
Score = 1074 bits (2777), Expect = 0.0, Method: Composition-based stats.
Identities = 372/932 (39%), Positives = 569/932 (61%), Gaps = 16/932 (1%)
Query: 42 MNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPP 101
+ +I+ + + K D R YR + L N ++ LL+ DP TDK+SA+++V++G+ SD
Sbjct: 80 LTMGSIEHLTESLEKPELDDRSYRVIRLPNKLEALLVHDPDTDKASASVNVNVGNFSDAD 139
Query: 102 NIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGA 161
++ G++H EH+LF+GTKK+PKEN Y+Q+L+ H+GSSNA+T+ TNY+F+ L GA
Sbjct: 140 DMPGMAHAVEHLLFMGTKKFPKENAYNQYLASHSGSSNAYTAATETNYFFE-PSSPLYGA 198
Query: 162 LDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTG 221
LDRFAQFF+ PLF ES DRE+ AVDSE++KN+ +D WRL QL K+ NP HP+ F TG
Sbjct: 199 LDRFAQFFVSPLFLESTLDRELRAVDSENKKNLQSDLWRLMQLNKSLSNPGHPYHHFSTG 258
Query: 222 NKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENK 281
N TL+ P + G++VR E +KF+ +YS+N M +CVLGRESLD+L V +LFSEVENK
Sbjct: 259 NLKTLKEDPEKRGLEVRSEFIKFYEKHYSANRMRLCVLGRESLDELEKWVEELFSEVENK 318
Query: 282 NVPLPEFPE-HPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGH 340
++P + + P++ E L P+ D R+L + FP D + Y+S P Y+ HLIGH
Sbjct: 319 DLPQNRWDDVQPWRPEDLGVQIFAKPVMDNRSLDIYFPFLDEEYLYESQPSRYISHLIGH 378
Query: 341 EGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQK 400
EGPGS+L+ +K+KGW N L G G F I++ LT+EGL ++ +F+YI
Sbjct: 379 EGPGSILAYIKAKGWANGLSAGVMPICPGSAAFTISIRLTKEGLQQYREVAKVVFEYIAM 438
Query: 401 LRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFR 460
L+ PQ+WVF E K+L V FRFK K +TS+++ ++ E L + LL +F
Sbjct: 439 LKEREPQQWVFDEMKNLAEVEFRFKQKSPASRFTSRLSSVMQKPMPREWLLSGSLLRKFD 498
Query: 461 PDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNA---- 516
P+LI+ L L+P+N R+ +VS+ G D E+WYGT+YK + +P + + +NA
Sbjct: 499 PELIKKALACLQPDNFRMIVVSQEHPGDWDSKEKWYGTEYKVQKLPQDFMADIKNALATT 558
Query: 517 --DLNGKFKLPTKNEFIPTNFEILPLE-KEATPYPALIKDTAMSKLWFKQDDKFFLPKAC 573
+ +P +NEF+PT + + E P LI+ +LWFK+DD+F++PK
Sbjct: 559 PETRLSELHMPHENEFVPTRLSVEKKDISEPAKTPKLIRHDEHVRLWFKKDDRFWVPKGT 618
Query: 574 LNFEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKG 633
++ +P A+ P + + LY EL+KD+L EY+Y AELAGL Y L +++G+ +SV G
Sbjct: 619 VHITLRNPLAWATPANLVKSKLYCELVKDALVEYSYDAELAGLDYHLSASVFGLDISVGG 678
Query: 634 YNDKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEV 693
YNDK +LL+K++ M ++ RF IIKE R N +QP Y R L E
Sbjct: 679 YNDKMAVLLEKVLTSMRDLVVNPDRFHIIKERLSRGYRNAEYQQPFYQVGDYTRHLTAEK 738
Query: 694 AWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHA 753
W ++ L+ + + F PQLL + H+E L HGN+ K+ AL + +VE+ L
Sbjct: 739 TWINEQYAAELEHIEPEDISNFFPQLLQQNHVEVLAHGNLYKEDALRMTDLVENVL---- 794
Query: 754 HTKPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSE---NMFLEL 810
++PL SQ R + +P +VY++ + N I Y + S + L L
Sbjct: 795 QSRPLPQSQWHVRRNIIIPPGSNYVYERTLQDPANVNHCIEYYVYVGSIRDDILRAKLLL 854
Query: 811 FCQIISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITM 870
F Q+ EP F+ LR+KEQLGY+V+SG R + G R IIQSE+ YLESR++ FLI
Sbjct: 855 FAQMTDEPAFDQLRSKEQLGYVVWSGARYSATTIGYRVIIQSERTAEYLESRIDNFLIQA 914
Query: 871 EKSIEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKT 930
+++E+M+++ F+ H +++ +RL+K K LS+E +++W I S+ ++F ++ T+ A ++T
Sbjct: 915 GETLENMSDKDFEGHKRSVVNKRLEKLKNLSSETSRFWSHIGSEYFDFVQNETDAANVRT 974
Query: 931 LTKEDIIKFYKEMLAVDAPRRHKVSVHVLARE 962
LTK DI+ FYK+++ +P R K+S+++ A+
Sbjct: 975 LTKADIVDFYKQLIDPRSPTRGKLSIYLNAQA 1006
>ref|XP_001354132.1| GA18943-PA [Drosophila pseudoobscura]
gb|EAL29871.1| GA18943-PA [Drosophila pseudoobscura]
Length = 1055
Score = 1071 bits (2771), Expect = 0.0, Method: Composition-based stats.
Identities = 449/987 (45%), Positives = 656/987 (66%), Gaps = 27/987 (2%)
Query: 52 NHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCE 111
N+I KS +D R+YRGL+L NG+KVLLISDP TD S+AAL V +G +SDP N+ GL+HFCE
Sbjct: 67 NNIEKSQQDTRDYRGLQLENGLKVLLISDPNTDVSAAALSVQVGHMSDPQNLPGLAHFCE 126
Query: 112 HMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLC 171
HMLFLGT+KYP EN Y+ +LS+ GSSNA T T Y+F V+ + L+GALDRFAQFF+
Sbjct: 127 HMLFLGTEKYPHENGYTTYLSQSGGSSNAATYPLMTKYHFHVAPDKLDGALDRFAQFFIA 186
Query: 172 PLFDESCKDREVNAVD---------------------SEHEKNVMNDAWRLFQLEKATGN 210
PLF S +RE+NAV+ SEHEKN+ +D WR+ Q+ +
Sbjct: 187 PLFTPSATEREINAVNTQLHPRFTQIWALTKNSLQVNSEHEKNLPSDLWRIKQVHRHLAK 246
Query: 211 PKHPFSKFGTGNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNL 270
P H +SKFG+GNK TL P IDVR+ELLKFH +YS+N+M + V+G+ESL++L ++
Sbjct: 247 PDHAYSKFGSGNKTTLSEIPKSMNIDVREELLKFHKEWYSANIMCLAVIGKESLNELESM 306
Query: 271 VVKLFSEVENKNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNP 330
V++ FSE+ENK+V +PE+P HP+ E+ Q KIVPIKD+R+L ++F DL K+YKS P
Sbjct: 307 VMEKFSEIENKSVAVPEWPRHPYGEDRYGQKVKIVPIKDVRSLTISFTTDDLTKFYKSGP 366
Query: 331 GHYLGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDI 390
+YL HLIGHEG GS+LSEL+ GW N L+ G + GF FF I VDLT+EGL HV+DI
Sbjct: 367 DNYLTHLIGHEGKGSILSELRRLGWCNDLMAGHQNTQNGFGFFDIVVDLTQEGLEHVDDI 426
Query: 391 ILHMFQYIQKLRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVL 450
+ +FQY++ LR EGP++W+F EC LN + FRFK+KE+P + + +PLEEVL
Sbjct: 427 VNIIFQYLRMLREEGPKKWIFDECVKLNEMRFRFKEKEQPENLVTHAVSSMQIFPLEEVL 486
Query: 451 TAEYLLEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVI 510
A YL E+RPDLI +LD+LRP R+ IVS+SFE D+ E +Y T+Y E IP +++
Sbjct: 487 IAPYLSNEWRPDLISGLLDELRPSKSRIVIVSQSFEPTCDQAEPYYKTKYGLERIPTDIV 546
Query: 511 KKWQNADLNGKFKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLP 570
+ W+ DLN KL N FIPTNF+I + + +P +I DT + ++W KQD++F P
Sbjct: 547 QSWEKCDLNENLKLSLPNSFIPTNFDIADVPSDGPKHPTIILDTPILRVWHKQDNQFNKP 606
Query: 571 KACLNFEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLS 630
KAC+ F+ +P A +DPL+CN+ ++ + LLKD LNEY Y AELA L ++ G+ +
Sbjct: 607 KACMRFDMSNPLASLDPLNCNLNHMMVMLLKDQLNEYLYDAELANLKLNVVGKSGGIDFT 666
Query: 631 VKGYNDKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLM 690
+ G++DKQ +LL+K+++ + F +DEKRF+I+KE Y+RSL NF+AEQP+QH++YYL LL+
Sbjct: 667 IHGFSDKQVVLLEKLLDHLFDFRVDEKRFDILKEEYVRSLKNFKAEQPYQHSIYYLALLL 726
Query: 691 TEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTL- 749
TE AW EL +A++ VT R+ F + RLH E + GN+TKQ A + V L
Sbjct: 727 TENAWANVELLDAMELVTYDRVNNFAKEFFQRLHTECFIFGNVTKQHATEVAGRVNTRLE 786
Query: 750 IEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLE 809
+A P+L Q+++ RE +L +++++ NE H + ++Y Q Q+ N+ +
Sbjct: 787 ATNASKLPILARQMLKKREYKLLAGDSYLFEKENEYHKSSCTQLYLQCGAQTDHTNIMVN 846
Query: 810 LFCQIISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLIT 869
L Q++SEPC++ LRTKEQLGYIVFSG R+ NG G+R I+QS K P ++E R+E FL T
Sbjct: 847 LVSQVLSEPCYDCLRTKEQLGYIVFSGVRKVNGANGIRIIVQSAKHPTFVEDRIENFLQT 906
Query: 870 MEKSIEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLK 929
++IEDM + F++H +ALA+++L+KPK + + +++GEI Q Y+F+R+ EVA L+
Sbjct: 907 YLQAIEDMPLDEFERHKEALAVKKLEKPKTIFQQFIQFYGEIAMQTYHFEREEAEVAILR 966
Query: 930 TLTKEDIIKFYKEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQP 989
++K D + ++K+ +A D R +SVH+++++ D V E + + ++ + +
Sbjct: 967 KISKSDFVDYFKKFIAKDGGERRVLSVHIVSKQTDEN--VSEPKEEEPLEITN---MERH 1021
Query: 990 EVIQNMTEFKRGLPLFPLVKPHINFMA 1016
+ I ++ FK L+P+ P ++ A
Sbjct: 1022 KCISDIVAFKSCKELYPIALPFLDIKA 1048
>ref|NP_001060044.1| Os07g0570300 [Oryza sativa (japonica cultivar-group)]
dbj|BAC79700.1| putative insulin degrading enzyme [Oryza sativa Japonica Group]
dbj|BAF21958.1| Os07g0570300 [Oryza sativa (japonica cultivar-group)]
Length = 988
Score = 1069 bits (2765), Expect = 0.0, Method: Composition-based stats.
Identities = 373/962 (38%), Positives = 555/962 (57%), Gaps = 16/962 (1%)
Query: 53 HITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEH 112
IT+ DKR YR + L N ++ LL+SDP TDK++A+++V +G DP + GL+HF EH
Sbjct: 30 EITRPRNDKRGYRRVVLPNDLECLLVSDPDTDKAAASMNVSVGYFCDPEGLEGLAHFLEH 89
Query: 113 MLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCP 172
MLF ++KYP E+ YS++++EH GS+NAFT+ EHTN++FDV+H+ L ALDRFAQFF+ P
Sbjct: 90 MLFYASEKYPIEDSYSKYITEHGGSTNAFTTCEHTNFFFDVNHDCLNDALDRFAQFFIKP 149
Query: 173 LFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQ 232
L RE+ AVDSE++KN+++D WR+ QL+ HP+ KFGTGN TLE +P +
Sbjct: 150 LLSADATLREIKAVDSENQKNLLSDPWRMNQLQNHISLESHPYHKFGTGNWDTLEVKPKE 209
Query: 233 EGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHP 292
+G+D R EL+KF+ ++YS+NLM + V G+ESLD+L LV F V N FP HP
Sbjct: 210 KGLDTRLELIKFYDSHYSANLMQLVVYGKESLDNLQTLVENKFCGVRNTGRERFSFPGHP 269
Query: 293 FQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKS 352
EHL+ L K VPIK L + +PI ++YK P Y+ HLIGHEG GSL LK
Sbjct: 270 CSSEHLQVLVKAVPIKQGHTLRILWPITPNIRHYKEGPCKYVSHLIGHEGEGSLFYVLKK 329
Query: 353 KGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQ 412
GW +L G+ + + F FF + + LT+ G H+EDI+ +F+YI L+ G +W+F
Sbjct: 330 LGWAMSLEAGEGDWSYEFSFFSVVIKLTDVGHEHMEDIVGLLFRYITLLQTSGTLKWIFD 389
Query: 413 ECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLR 472
E + + F ++DK P Y + I+ + YP E+ L A + +F PD I+ +L++L
Sbjct: 390 ELQTICETGFHYRDKGPPIHYVANISSNMQIYPPEDWLIASSVPSKFSPDAIQGILNELT 449
Query: 473 PENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIP 532
P+NVR+ SK FEG+T+ TE WYGT Y EA+P +I+KW +P N F+P
Sbjct: 450 PDNVRIFWESKKFEGQTNLTEPWYGTSYSVEAVPPSIIQKWVEKAPVEDLHMPKPNIFLP 509
Query: 533 TNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNM 592
++ + E++A+ +P +++ T S++W+K D FF PKA + +F P + P +
Sbjct: 510 SDLSLKNAEEKAS-FPCMLRKTLFSRVWYKPDTMFFTPKAYIKMDFHCPLSRSSPESSVL 568
Query: 593 AYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATF 652
++ LL D LN+YAY A++AGL Y ++ G +++ GYNDK LL+ +I K+A F
Sbjct: 569 TDVFTRLLMDYLNDYAYDAQVAGLYYGVRPNDTGFQITMVGYNDKMRTLLETVIGKIAEF 628
Query: 653 EIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRL 712
E+ RF +IKE + NF+ QP+Q A YY L++ E W DE A+ + L
Sbjct: 629 EVKADRFSVIKETITKEYENFKFRQPYQQAFYYCSLILEEQTWAWDEELAAVSQIEASDL 688
Query: 713 KAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHA--HTKPLLPSQLVRYREVQ 770
+ F+P LL + IE+ GN+ A G+MQ VED L K L SQ + R V+
Sbjct: 689 EKFLPHLLGKTFIESYFAGNMEPGAVKGVMQHVEDILFNAPVSLCKALPSSQHLTKRIVK 748
Query: 771 LPDRGWFVYQQ--RNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQ 828
L + Y N N + Y Q +N+ L+L + +P F+ LR+ EQ
Sbjct: 749 LERGLRYYYPALCLNHQDENSCLLHYIQIHQDDLKKNVILQLLALVAKQPAFHQLRSVEQ 808
Query: 829 LGYIVFSGPRRANGIQGLRFIIQSE-KPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQ 887
LGYI + +G++GL+FIIQS K P L++RVEAFL E ++ M + F+ ++
Sbjct: 809 LGYITLLRQKNDSGVRGLQFIIQSTVKDPANLDARVEAFLTMFEGTLYQMPDTEFKSNVN 868
Query: 888 ALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVD 947
AL +L+K K + E A +WGEI FDR EVA L+ L KE++I+F+ + V+
Sbjct: 869 ALIDMKLEKYKNIREESAFFWGEISEGTLKFDRKEVEVAALRDLKKEELIEFFNNHVKVN 928
Query: 948 APRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPL 1007
AP++ +S+ V G + + + P P I ++ F+R PL+
Sbjct: 929 APQKKILSIQVYG---------GLHSSEYEKIVHDEPR-PNSYQITDIFNFRRSRPLYGS 978
Query: 1008 VK 1009
K
Sbjct: 979 YK 980
>gb|ABH09708.1| STE23-like protein [Penicillium marneffei]
Length = 1038
Score = 1057 bits (2734), Expect = 0.0, Method: Composition-based stats.
Identities = 387/1032 (37%), Positives = 589/1032 (57%), Gaps = 63/1032 (6%)
Query: 42 MNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPP 101
M + I + + K D R YR ++L N ++ LL+ DP TDK+SA+ +V++G+ SD
Sbjct: 1 MTMSEVTHITDRLEKPELDDRSYRVIKLGNQLEALLVHDPDTDKASASANVNVGNFSDEE 60
Query: 102 NIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSH------ 155
+ G++H EH+LF+GT+KYPKEN Y+Q+L+ H+GSSNA+T TNY+F+V+
Sbjct: 61 AMPGMAHAVEHLLFMGTEKYPKENAYNQYLASHSGSSNAYTGAIETNYFFEVAATGESKS 120
Query: 156 ------------------------EHLEGALDRFAQFFLCPLFDESCKDREVNAVDSEHE 191
L GALDRFAQFF+ PLF ES DRE+ AVDSE++
Sbjct: 121 PESANGEKSAVSSSTTALSKDSATSPLYGALDRFAQFFIAPLFLESTLDRELRAVDSENK 180
Query: 192 KNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQELLKFHSAYYSS 251
KN+ +D WRL QL K+ NP+HP+ KF TGN TL P G++VR + ++FH +YS+
Sbjct: 181 KNLQSDVWRLMQLNKSLSNPEHPYHKFSTGNLQTLRDDPQSRGVEVRSKFIEFHKKHYSA 240
Query: 252 NLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPE-HPFQEEHLKQLYKIVPIKDI 310
N M + VLGRESLD L + VV+LFSEV+NKN+P + + P + L P+ D
Sbjct: 241 NRMKLVVLGRESLDQLESWVVELFSEVQNKNLPQNRWDDVQPLSADQLCTQVFAKPVMDS 300
Query: 311 RNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGARGF 370
R+L + FP D + Y++ P Y+ HLIGHEGPGS+LS +K+KGW N L G G
Sbjct: 301 RSLDIYFPFLDEDELYETLPSRYISHLIGHEGPGSILSYIKAKGWANGLSAGAMSVGPGS 360
Query: 371 MFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAVAFRFKDKERP 430
FF I+V LTE+GL H ++I+ +FQ+I ++ P++W++ E ++L V FRFK K
Sbjct: 361 AFFTISVRLTEDGLTHYKEIVKIIFQHIAMIKERAPEKWIYDEMQNLAEVEFRFKQKSPA 420
Query: 431 RGYTSKIAGILHYY-PLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKT 489
+TS+++ ++ P E +L+ LL +F DLI L LR +N R+ IVS+ F G
Sbjct: 421 SRFTSRLSSVMQKPLPREWLLSGNNLLRKFDADLITKALSYLRSDNFRLMIVSQHFPGDW 480
Query: 490 DRTEEWYGTQYKQEAIPDEVIKKWQNA------DLNGKFKLPTKNEFIPTNFEILPLE-K 542
D E+WYGT YK+E IP + + + +NA + +P KNEFIPT + E
Sbjct: 481 DAKEKWYGTDYKEEKIPQDFLTEIRNALASAPSERVSDLHMPHKNEFIPTRLSVEKKEVA 540
Query: 543 EATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELLKD 602
+ P P LI+ ++W+K+DD+F++PKA ++ + + P + A LY EL++D
Sbjct: 541 QPAPTPKLIRLDDHVRVWYKKDDRFWVPKATVHITLRNSLVWATPANHVKAKLYCELVRD 600
Query: 603 SLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFEII 662
+L EY+Y AELAGL Y+L +I+G+ +SV GYNDK +LL+K++ M + RF+II
Sbjct: 601 ALVEYSYDAELAGLDYNLSASIFGLDVSVGGYNDKMSVLLEKVVTTMRDLVVLPDRFKII 660
Query: 663 KEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSR 722
KE R+ N +QP+ R L E W ++ L+ + + AF PQLL +
Sbjct: 661 KERLTRAYRNAEYQQPYYQVGDMTRYLTAEKTWINEQYAAELEHIEADDVAAFFPQLLRQ 720
Query: 723 LHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQR 782
HIE L HGN+ K+ AL + +VE+ + ++ L SQ R + P ++Y+++
Sbjct: 721 NHIEVLAHGNLYKEDALKMTDIVENIM----RSRTLPQSQWHVRRNIIFPPGSNYIYERQ 776
Query: 783 NEVHNNCGIEIYYQTDMQSTSE---NMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRR 839
+ N I Y + ++ L L Q+ EP F+ LR+KEQLGY+V+SG R
Sbjct: 777 LKDPQNVNNCIEYYLFVGKITDEVLRAKLLLLAQMTEEPAFDQLRSKEQLGYVVWSGARY 836
Query: 840 ANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKK 899
+ G R IIQSE+ YLE R++ FL K++++MTEE F+ H +++ +RL+K K
Sbjct: 837 SATTIGYRVIIQSERTAQYLEGRIDNFLAQFAKTLDEMTEEEFESHKRSIINKRLEKLKN 896
Query: 900 LSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVL 959
L +E +++W I S+ +NF + + A ++TLTK DI+ F+++ + + R K+S+H+
Sbjct: 897 LGSETSRFWTHIGSEYFNFLQHEVDAATVRTLTKPDIVAFFRQYIDPSSETRAKISIHLN 956
Query: 960 AR--EMDSCPV---------VGEFPCQNDINLSQAPALP------QPEVIQNMTEFKRGL 1002
A+ + D PV +++LS QP I N+ +FK L
Sbjct: 957 AQSAKTDELPVDTSETAEGAESLHNQLTNVSLSNGDVTTIKTTSRQPIYITNVPQFKARL 1016
Query: 1003 PLFPLVKPHINF 1014
P+ P P ++
Sbjct: 1017 PVSPGPSPVVDL 1028
>ref|XP_681313.1| hypothetical protein AN8044.2 [Aspergillus nidulans FGSC A4]
gb|EAA59666.1| hypothetical protein AN8044.2 [Aspergillus nidulans FGSC A4]
Length = 1100
Score = 1054 bits (2727), Expect = 0.0, Method: Composition-based stats.
Identities = 378/961 (39%), Positives = 568/961 (59%), Gaps = 44/961 (4%)
Query: 42 MNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPP 101
M + +R+ + K D R YR ++L N ++ LL+ DP TDK++AA+DVH+GS SDP
Sbjct: 1 MTMRSAERLTEGLEKPSLDDRSYRVIQLPNKLEALLVHDPETDKAAAAMDVHVGSFSDPA 60
Query: 102 NIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVS------- 154
++ GL+H EHMLF+GT+KYP EN Y+Q+L+ H+GSSNA+T+G TNY+F+VS
Sbjct: 61 DLQGLAHGLEHMLFMGTEKYPVENAYNQYLASHSGSSNAYTAGTETNYFFEVSATGATGE 120
Query: 155 ----------------------HEHLEGALDRFAQFFLCPLFDESCKDREVNAVDSEHEK 192
L GALDRFAQFF+ PLF E+ DRE+ AVDSE++K
Sbjct: 121 SSGQVTPNGTTNGTSAESKSNGPSPLYGALDRFAQFFISPLFLENTLDREMQAVDSENKK 180
Query: 193 NVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQELLKFHSAYYSSN 252
N+ +D WRL QL K+ NP HP++ F TGN TL+ P + G+++R E +KF+ +YS+N
Sbjct: 181 NLQSDLWRLMQLNKSLSNPDHPYNHFSTGNLQTLKEEPQKRGVEIRNEFMKFYEKHYSAN 240
Query: 253 LMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQ-EEHLKQLYKIVPIKDIR 311
M + VLGRESLD+L V +LF+ V NK++P + P + + P+ D R
Sbjct: 241 RMKLVVLGRESLDELEKWVSELFAGVSNKDLPQNRWDGIPIWLPNDMCKQIFAKPVMDTR 300
Query: 312 NLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFM 371
++ + FP D +K Y+S P Y+ HLIGHEGPGS+L+ +K+KGW N L G G
Sbjct: 301 SVDIYFPFLDEEKLYESQPSRYISHLIGHEGPGSILAYIKAKGWANGLSAGVMPVCPGAA 360
Query: 372 FFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAVAFRFKDKERPR 431
FF ++V LT+EGL + ++ +F+YI ++ P+ W+F+E K+L V F+FK K
Sbjct: 361 FFTVSVRLTQEGLQQYQQVVKVIFEYIAMIKEREPEAWIFEEMKNLAEVEFKFKQKSPAS 420
Query: 432 GYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDR 491
+TS+++ ++ E L + LL +F P+ I+ L LR +N ++ +V++ + G D
Sbjct: 421 RFTSRLSSVMQKPLPREWLLSGSLLRKFDPEAIKKALSYLREDNFKLIVVAQDYPGDWDT 480
Query: 492 TEEWYGTQYKQEAIPDEVIKKWQNA------DLNGKFKLPTKNEFIPTNFEILPLE-KEA 544
E+WYGT+YK E +P + + + A + +P KNEF+PT + E E
Sbjct: 481 KEKWYGTEYKVEDVPKDFMSGIRAALDTTPETRLKELHMPHKNEFVPTRLSVEKKEVSEP 540
Query: 545 TPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELLKDSL 604
P LI+ +LWFK+DD+F++PKA + +P + P + + LY EL++D+L
Sbjct: 541 QKTPKLIRHDDHVRLWFKKDDRFWVPKATVFVTLRNPLVWATPANLVKSKLYCELVRDAL 600
Query: 605 NEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFEIIKE 664
EY+Y AELAGL Y L +I+G+ +SV GYNDK +LL+K+ M EI+ RF IIKE
Sbjct: 601 VEYSYDAELAGLDYHLSASIFGLDISVGGYNDKMAVLLEKVFTSMRDLEINPDRFRIIKE 660
Query: 665 AYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLH 724
RS N +QP+ Y R L E W ++ LD + +K F PQ+L + H
Sbjct: 661 RLTRSYKNAEYQQPYYQVGDYTRYLTAERGWLNEQYAAELDHIEAEDIKCFFPQILRQNH 720
Query: 725 IEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQRNE 784
IE L HGNI K+ AL + VE L +++ L SQ R V +P ++Y++ +
Sbjct: 721 IEVLAHGNIYKEDALRMTDTVESIL----NSRTLPQSQWYVRRNVIIPPGSDYIYERPLK 776
Query: 785 VHNNCGIEIYYQTDMQSTSE---NMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRAN 841
N I Y + S ++ L LF Q+ EP F+ LR+KEQLGY+V+SG R +
Sbjct: 777 DPANVNHCIEYYLFIGSIADEVLRAKLLLFAQMTDEPAFDQLRSKEQLGYVVWSGARYSA 836
Query: 842 GIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKLS 901
G R IIQSE+ YLESR+++FL K++E MTE+ F+ H +++ +RL+K K LS
Sbjct: 837 TTIGYRVIIQSERTAQYLESRIDSFLSNFGKTLETMTEDEFEGHKRSVINKRLEKLKNLS 896
Query: 902 AECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLAR 961
+E +++W I S+ Y+F ++ T+ A ++ LTK DI+ FYK+M+ +P R K+S+H+ A+
Sbjct: 897 SETSRFWSHIGSEDYDFQQNETDAARVRALTKSDILDFYKQMIDPASPTRGKLSIHLKAQ 956
Query: 962 E 962
Sbjct: 957 A 957
>ref|XP_001397499.1| hypothetical protein An16g01860 [Aspergillus niger]
emb|CAK42803.1| unnamed protein product [Aspergillus niger]
Length = 1167
Score = 1054 bits (2727), Expect = 0.0, Method: Composition-based stats.
Identities = 374/971 (38%), Positives = 577/971 (59%), Gaps = 30/971 (3%)
Query: 11 PALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPEDKREYRGLELA 70
PAL S+ +++ LP R + +I+RI + K D R YR + L
Sbjct: 59 PALRSS-HALVSLSLPSRARFF------SNTATMGSIERIAEQLEKPELDDRSYRVIRLP 111
Query: 71 NGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKKYPKENEYSQF 130
N ++ LL+ DP TDK+SAA++V++G+ SD ++ G++H EH+LF+GT+KYPKEN Y+Q+
Sbjct: 112 NKLEALLVHDPDTDKASAAVNVNVGNFSDADDMPGMAHAVEHLLFMGTQKYPKENAYNQY 171
Query: 131 LSEHAGSSNAFTSGEHTNYYFDV--------SHEHLEGALDRFAQFFLCPLFDESCKDRE 182
L+ H+GSSNA+T+ TNY+F++ L GALDRFAQFF+ PLF ES DRE
Sbjct: 172 LASHSGSSNAYTAATETNYFFEIDTPAKPNYPTSPLYGALDRFAQFFVEPLFLESTLDRE 231
Query: 183 VNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQELL 242
+ AVDSE++KN+ +D WRL QL K NP HP+ F TGN TL+ P + G++VRQE +
Sbjct: 232 LRAVDSENKKNLQSDLWRLMQLNKTLSNPAHPYHHFSTGNLQTLKEEPQKRGLEVRQEFI 291
Query: 243 KFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPE-HPFQEEHLKQL 301
KF+ A+YSSN+M + VLGR+ LD++ V LF V+N+++P + P EHL +
Sbjct: 292 KFYQAHYSSNIMKLVVLGRDPLDEMEQWVGDLFKHVKNQDLPQNRWDHAQPCLPEHLGKQ 351
Query: 302 YKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLVG 361
P+ D+R+L + FP D + ++S P YL HLIGHEGPGS+L+ +K+KGW N L
Sbjct: 352 IFAKPVMDMRSLDIYFPFMDEESMFESQPSRYLSHLIGHEGPGSILAYIKAKGWANGLSA 411
Query: 362 GQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAVA 421
G G FF I+V LT EGL ++ +F+YI ++ PQ+W+F E K+L V
Sbjct: 412 GVMPVCPGSAFFTISVRLTPEGLKQYREVTKVVFEYIGMIKEREPQQWIFDEMKNLAEVE 471
Query: 422 FRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAIV 481
FRFK K +TS+++ ++ E L + LL +F P+L++ L LRP+N R+ IV
Sbjct: 472 FRFKQKSPASRFTSRLSSVMQKPYPREWLLSGSLLRKFEPELVKKALSYLRPDNFRMVIV 531
Query: 482 SKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNA------DLNGKFKLPTKNEFIPTNF 535
++ + G + E+WYGT+YK E IP + + + A + +P KNEF+PT
Sbjct: 532 AQDYPGDWNCREKWYGTEYKVEDIPQDFMDSIRKAVETSPESRLSELHMPHKNEFVPTRL 591
Query: 536 EILPLE-KEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAY 594
+ E E P LI+ +LW+K+DD+F++PKA ++ +P + P + A
Sbjct: 592 SVEKKEVSEPAKTPKLIRHDDHVRLWYKKDDRFWVPKATVHITLRNPLVWATPANLVKAK 651
Query: 595 LYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEI 654
Y EL++D+LNEY+Y AELAGL Y L +++G+ +SV GYNDK +LL+K++ M +
Sbjct: 652 FYSELVRDALNEYSYDAELAGLDYSLSASLFGLDISVGGYNDKMSVLLEKVLTSMRDLVV 711
Query: 655 DEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKA 714
RF IIKE R+ N +QP Y R L E W ++ L+ + +
Sbjct: 712 KPDRFNIIKERMTRNYKNAEYQQPFYQVGDYTRYLTAERTWLNEQYAAELEHIEAEDVSC 771
Query: 715 FIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDR 774
F PQ+L + HIE L HGN+ K+ AL + +VE TL ++ L SQ R + LP
Sbjct: 772 FFPQILRQNHIEVLAHGNLYKEDALRMTDLVESTL----QSRTLPESQWYVRRNMILPPG 827
Query: 775 GWFVYQQ--RNEVHNNCGIEIYYQTD-MQSTSENMFLELFCQIISEPCFNTLRTKEQLGY 831
++Y++ ++ + N IE Y + + L LF Q+ EP F+ LR+KEQLGY
Sbjct: 828 ANYIYERTLKDPANVNHCIEYYLFIGKIDDDALRAKLLLFAQMTDEPAFDQLRSKEQLGY 887
Query: 832 IVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAI 891
+V+SG R + G R IIQSE+ YLESR+++FL KS+++M+E+ F+ H +++
Sbjct: 888 VVWSGARYSATTMGYRVIIQSERNAPYLESRIDSFLTGFGKSLQNMSEQDFENHKRSVVN 947
Query: 892 RRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRR 951
+RL+K K LS+E ++W I S+ ++F ++ ++ A ++ LT+ D+I+F+++ + + R
Sbjct: 948 KRLEKLKNLSSETNRFWSHIGSEYFDFVQNESDAANVRKLTQADLIQFFQQFVDPTSATR 1007
Query: 952 HKVSVHVLARE 962
K+++H+ A+
Sbjct: 1008 AKLAIHLKAQA 1018
>dbj|BAC79699.1| putative insulin degrading enzyme [Oryza sativa Japonica Group]
Length = 998
Score = 1052 bits (2720), Expect = 0.0, Method: Composition-based stats.
Identities = 367/965 (38%), Positives = 560/965 (58%), Gaps = 17/965 (1%)
Query: 51 GNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFC 110
IT+ DKR YR + L N ++ LL+SDP TDK++A+++V +G DP + GL+HF
Sbjct: 37 DAEITRPRNDKRGYRRVVLPNALECLLVSDPDTDKAAASMNVSVGYFCDPERLPGLAHFL 96
Query: 111 EHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFL 170
EHMLF ++KYP E++YS++++EH GS+NAFT E TN+YFDV++ L+ ALDRFAQFF+
Sbjct: 97 EHMLFYASEKYPVEDDYSKYIAEHGGSTNAFTCRERTNFYFDVNNSCLDDALDRFAQFFI 156
Query: 171 CPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRP 230
PL RE+NAVDSE++KN+++D R+ QL+K + HP+ KF TGN TL P
Sbjct: 157 KPLISPDATLREINAVDSENKKNLLSDPLRMSQLQKHFCSESHPYHKFSTGNLDTLLVNP 216
Query: 231 NQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPE 290
N+EG+D +EL+KF++++YS+NLM + V G+ESLD+L NLV FS+V N F
Sbjct: 217 NKEGLDTLEELIKFYNSHYSANLMQLVVYGKESLDNLQNLVENKFSDVRNTGRESFSFHG 276
Query: 291 HPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSEL 350
HP EHL+ + K VPIK+ L + +PI ++YK P Y+ L+GHEG GSL L
Sbjct: 277 HPCSSEHLQIIVKAVPIKEGHTLRIQWPITPNIQHYKEGPCKYVSRLVGHEGEGSLFYVL 336
Query: 351 KSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWV 410
K+ GW +L + + + F FF + + LT+ G H+EDII +F+YI L+ G ++W+
Sbjct: 337 KNLGWAMSLYAWEGDWSYEFSFFNVVIQLTDVGYEHMEDIIGLLFRYIALLQTSGTRQWI 396
Query: 411 FQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDK 470
F E ++ + F ++DK P Y I+ + +P E+ L A + +F PD I+ +L+
Sbjct: 397 FDELVAISEMGFHYRDKSPPIHYVVNISSNMQIFPPEDWLIASSVPSKFSPDAIQNILND 456
Query: 471 LRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEF 530
L P+NVR+ SK FEG+T+ TE WYGT Y EA+ +I+KW N +P N F
Sbjct: 457 LTPDNVRIFWESKKFEGQTNLTEPWYGTSYSVEAVTPSIIQKWVNMAPMEDLHIPKPNIF 516
Query: 531 IPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHC 590
IP++ + +E++ + +P +++ T S++W+K D FF PKA + +F P + P
Sbjct: 517 IPSDLSLKNVEEKGS-FPCMLRKTMFSRVWYKPDTMFFTPKAYVKMDFHCPLSNSSPEST 575
Query: 591 NMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMA 650
+ ++ L+ D LN++AY A++AGL Y ++ + G +++ GYNDK LL +I K+A
Sbjct: 576 VLTDMFTRLIMDYLNDFAYDAQIAGLYYFIRPSDTGFQITMVGYNDKMRTLLDTVIGKIA 635
Query: 651 TFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLP 710
FE+ RF +IKE ++ NF+ QP++ A YY L++ E W DE A+ +
Sbjct: 636 EFEVKVDRFAVIKETIIKDYENFKFRQPYEQAFYYCSLILEEQTWAWDEKLAAVSHIEAS 695
Query: 711 RLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHT--KPLLPSQLVRYRE 768
L+ F+P+LL + IE GN+ A ++Q VEDTL + K L PSQ + R
Sbjct: 696 DLQIFLPRLLGKTFIECYFAGNMEPGEAKSVIQHVEDTLFNAPISFCKALPPSQHLTKRI 755
Query: 769 VQLPDRGWFVYQQ---RNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRT 825
V+L + Y ++ N I Y Q +N+ L+L + +P F+ LR+
Sbjct: 756 VKLERGWRYYYPALCLNHQDEKNSSILHYIQIHQDDLKQNVLLQLLALVAKQPAFHQLRS 815
Query: 826 KEQLGYIVFSGPRRANGIQGLRFIIQSE-KPPHYLESRVEAFLITMEKSIEDMTEEAFQK 884
EQLGYI R +G++GL+FIIQS K P L+ RVEAFL E ++ M +E F+
Sbjct: 816 VEQLGYITVLTQRNDSGVRGLQFIIQSTVKDPSNLDDRVEAFLNMFEGTLYQMPDEEFKS 875
Query: 885 HIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEML 944
++ AL +L+K K + E A +W EI FDR EVA L+ L KE++I+F+ +
Sbjct: 876 NVNALIDMKLEKYKNIREESAFFWKEISEGTLKFDRKEAEVAALRDLNKEELIEFFNNHV 935
Query: 945 AVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPL 1004
V+AP++ +S+ V G + + + P P I ++ F+R PL
Sbjct: 936 KVNAPQKKILSIQVYG---------GLHSSEYEKIVHDEPQ-PHSYQITDIFSFRRSRPL 985
Query: 1005 FPLVK 1009
+ K
Sbjct: 986 YGSFK 990
>emb|CAO23585.1| unnamed protein product [Vitis vinifera]
Length = 965
Score = 1050 bits (2716), Expect = 0.0, Method: Composition-based stats.
Identities = 370/966 (38%), Positives = 542/966 (56%), Gaps = 16/966 (1%)
Query: 49 RIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSH 108
I K D REYR + L N ++ LLISDP TDK++A++ V +GS SDP GL+H
Sbjct: 3 EAAVEIVKPRTDTREYRRIVLRNSLEALLISDPDTDKAAASMSVSVGSFSDPEGFPGLAH 62
Query: 109 FCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQF 168
F EHMLF ++KYP E+ YS++++EH GS+NAFT+ EHTNY+FDV+ + E ALDRFAQF
Sbjct: 63 FLEHMLFYASEKYPLEDSYSKYITEHGGSTNAFTASEHTNYFFDVNTDCFEEALDRFAQF 122
Query: 169 FLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLET 228
F+ PL RE+ AVDSE++KN+++DAWR+ QL+K HP+ KF TGN+ TLE
Sbjct: 123 FVKPLMSADATTREIKAVDSENKKNLLSDAWRMDQLQKHVSAEGHPYHKFSTGNRDTLEV 182
Query: 229 RPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEF 288
+P ++G+D R EL+KF+ +YS+NLM + V +ESLD + +LV F E++NK+
Sbjct: 183 KPKEKGLDTRHELIKFYEEHYSANLMHLVVYTKESLDKIQSLVEHKFQEIQNKDRINFHI 242
Query: 289 PEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLS 348
P EHL+ L K VPIK L V +PI YK P YLGHLIGHEG GSL
Sbjct: 243 CGQPCTSEHLQILVKTVPIKQGHKLIVVWPITPSIHNYKEGPCRYLGHLIGHEGKGSLFY 302
Query: 349 ELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQE 408
LK+ GW +L +++ F FF + +DLT+ G H++DI+ +F+YI L+ G +
Sbjct: 303 ILKTLGWATSLSAWEEDWTCEFSFFEVVIDLTDAGHEHMQDIVGLLFKYISLLQQTGVCK 362
Query: 409 WVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVL 468
W+F E + F ++DK Y ++ + YP ++ L L +F PD+I+ VL
Sbjct: 363 WIFDELSAICETMFHYQDKIPSIDYVVNVSSNMELYPPKDWLVGSSLPSKFSPDVIQKVL 422
Query: 469 DKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKN 528
D+L P NVR+ SK+FEG TD E WYGT + E I +I++W A LP N
Sbjct: 423 DELAPNNVRIFWESKNFEGHTDMVEPWYGTAFSIEKITVSMIQQWMLAAPTEHLHLPDPN 482
Query: 529 EFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPL 588
+FIPT+ + ++ E +P L++ ++ S LW+K D F PKA + +F PFA P
Sbjct: 483 DFIPTDLSLKNVQ-EKAKFPVLLRKSSYSTLWYKPDTMFSTPKAYVKIDFNCPFASSSPE 541
Query: 589 HCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEK 648
+ ++ LL D LNE AY AE+AGL Y L NT G +++ GYN K ILL+ +++K
Sbjct: 542 ADVLTDIFTRLLMDYLNEDAYYAEVAGLYYCLSNTDSGFQVAMAGYNHKLRILLETVVKK 601
Query: 649 MATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVT 708
+A F++ RF +IKE + N + +QP+Q AM Y L++ + W + E + +
Sbjct: 602 IANFKVKPDRFLVIKELVTKGYQNVKFQQPYQQAMCYRSLILHDNTWPWMDGLEVIPHLE 661
Query: 709 LPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAH--TKPLLPSQLVRY 766
L F+P LLSR +E + GNI + A ++ +ED +PL PSQ +
Sbjct: 662 ADDLAKFVPMLLSRAFLECYIAGNIEPKEAEAMIHHIEDIFYSGPRPICQPLFPSQYLTN 721
Query: 767 REVQLPDRGWFVY--QQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLR 824
R ++L + Y + N N + Y Q N+ L+LF I + F+ LR
Sbjct: 722 RVIKLDRGMSYFYPAEGLNPSDENSALVHYIQVHRDDFLPNVKLQLFALIAKQQAFHQLR 781
Query: 825 TKEQLGYIVFSGPRRANGIQGLRFIIQSE-KPPHYLESRVEAFLITMEKSIEDMTEEAFQ 883
+ EQLGYI R +GI G++F+IQS K P +++SR+E FL E + M+E+ F+
Sbjct: 782 SVEQLGYITELMLRNDSGIHGVQFMIQSTVKGPGHIDSRIEEFLKMFEFKLYAMSEDEFK 841
Query: 884 KHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEM 943
++ L +L+K K L E YW EI FDR EVA LK LT++++I F+ E
Sbjct: 842 SNVNTLVDMKLEKYKNLWEESGFYWQEIYDGTLKFDRTEAEVAALKKLTQKELIDFFNEH 901
Query: 944 LAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLP 1003
+ V AP++ +SV V S + I I ++ +F++ P
Sbjct: 902 IKVGAPQKKTLSVRVYGCLHTSEYAEEQKEANQPIQ----------VKIDDIFKFRKSQP 951
Query: 1004 LFPLVK 1009
L+ K
Sbjct: 952 LYGSFK 957
>emb|CAC67408.1| insulin degrading enzyme [Solanum lycopersicum]
Length = 971
Score = 1048 bits (2711), Expect = 0.0, Method: Composition-based stats.
Identities = 377/967 (38%), Positives = 552/967 (57%), Gaps = 16/967 (1%)
Query: 48 KRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLS 107
+ + I K DKR+YR + L N +++LLISDP TDK +A+++V +G+ SDP + GL+
Sbjct: 8 ENMAVEIVKPRIDKRDYRRIVLQNNLEILLISDPETDKCAASMNVCVGAFSDPEGLEGLA 67
Query: 108 HFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQ 167
HF EHMLF ++KYP E+ YS++++E+ GS+NAFTS E TNYYF+V+ + E ALDRFAQ
Sbjct: 68 HFLEHMLFYASEKYPVEDSYSKYITENGGSTNAFTSSEDTNYYFEVNADGFEEALDRFAQ 127
Query: 168 FFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLE 227
FF+ PL RE+ AVDSEH+KN+++D WR+ QL+K HP+ KF TG+ TLE
Sbjct: 128 FFIKPLMSADATTREIKAVDSEHQKNLLSDPWRMNQLQKHLSAENHPYHKFSTGSWDTLE 187
Query: 228 TRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPE 287
RP + GID RQELLKF+S YS+NLM + V ++SLD + LV F ++ N +
Sbjct: 188 VRPKERGIDTRQELLKFYSENYSANLMHLVVYSKDSLDKVEQLVRGKFQDIRNIDRNQIH 247
Query: 288 FPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLL 347
F P EHL+ L + VPIK L + +PI +YK P YLGHLIGHEG GSL
Sbjct: 248 FTGQPCIMEHLQILVRAVPIKQGHKLKIIWPITPGIHHYKEGPCRYLGHLIGHEGEGSLF 307
Query: 348 SELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQ 407
LK GW +L G+ + F FF + +DLT+ G H EDI+ +F+YI L+ G
Sbjct: 308 YVLKKLGWATSLSAGESDWTNEFSFFKVAIDLTDAGQDHFEDIMGLLFKYIHLLQQAGAS 367
Query: 408 EWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMV 467
+W+F+E + AF ++DK RP Y +A + +YP E+ L A L +F P +I+
Sbjct: 368 KWIFEELSAICETAFHYQDKIRPSDYVVNVAMNMQHYPPEDWLVASSLPSKFNPSIIQSF 427
Query: 468 LDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTK 527
L++L P+NVR+ S FEG T TE WYGT Y E + + IK+W + + LP
Sbjct: 428 LNELNPDNVRIFWESTKFEGNTSMTEPWYGTAYSIEKVGGDSIKQWMEHAPSEELHLPAP 487
Query: 528 NEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDP 587
N FIPT+ + P+ E T P L++ + S+LW+K D F PKA + +F P+ P
Sbjct: 488 NVFIPTDLSLKPV-FEKTKVPILLRKSPYSRLWYKPDTAFSSPKAYVMIDFSCPYCGHSP 546
Query: 588 LHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIE 647
+ ++ LL D LNEYAY A++AGL YD+ T G L++ GYNDK +LL+ +IE
Sbjct: 547 EAEVLTEIFTRLLMDYLNEYAYNAQVAGLYYDISKTNSGFQLTLFGYNDKLRVLLEAVIE 606
Query: 648 KMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDV 707
K+A FE+ RF ++KE + NF+ +QP+Q MYY LL+ + W +E + L +
Sbjct: 607 KVAKFEVKPDRFSVVKELVTKQYQNFKFQQPYQQVMYYCSLLLKDNIWPWNEELDVLPHL 666
Query: 708 TLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAH--TKPLLPSQLVR 765
+ L F P L++R +E + GN+ + A ++Q++ED + +KPL SQ +
Sbjct: 667 KVDDLVKFYPLLMARSFMECYVAGNVEQAEAESMIQLIEDVFFKGPQSISKPLFASQHLT 726
Query: 766 YREVQLPDRGWFVY--QQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTL 823
R V L +VY + N N + Y Q N+ L+LF I +P F+ L
Sbjct: 727 NRVVNLERGVNYVYAAEGLNPSDENSALVHYIQVHQDDFMLNVKLQLFALIAKQPAFHQL 786
Query: 824 RTKEQLGYIVFSGPRRANGIQGLRFIIQS-EKPPHYLESRVEAFLITMEKSIEDMTEEAF 882
R+ EQLGYI R +G+ G++FI+QS K P Y+++RVE F+ E + +MT + F
Sbjct: 787 RSVEQLGYITVLMQRSDSGVHGVQFIVQSTAKDPKYIDTRVELFMKMFESKLYEMTSDEF 846
Query: 883 QKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKE 942
+ ++ AL +L+K K L E YW EI FDR + E+ LK LT++++ F+ E
Sbjct: 847 KNNVNALIDMKLEKHKNLREESRFYWREISDGTLKFDRRDREIVALKQLTQKELTDFFDE 906
Query: 943 MLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGL 1002
+ V PR+ +SV V S +F + + P I+ + F+R
Sbjct: 907 YIKVGVPRKKALSVRVYGSSHSS-----QFQAHKNEQME-----PNAVQIEEIFSFRRSR 956
Query: 1003 PLFPLVK 1009
PL+ K
Sbjct: 957 PLYSSFK 963
>gb|EAZ04397.1| hypothetical protein OsI_025629 [Oryza sativa (indica
cultivar-group)]
Length = 1015
Score = 1045 bits (2702), Expect = 0.0, Method: Composition-based stats.
Identities = 367/982 (37%), Positives = 560/982 (57%), Gaps = 34/982 (3%)
Query: 51 GNHITKSPEDKREYRGLELANGIKVLLISDPTTDK-----------------SSAALDVH 93
IT+ DKR YR + L N ++ LL+SDP TDK ++A+++V
Sbjct: 37 DAEITRPRNDKRGYRRVVLPNALECLLVSDPDTDKVSVLSLAPSIGDVPGVLAAASMNVS 96
Query: 94 IGSLSDPPNIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDV 153
+G DP + GL+HF EHMLF ++KYP E++YS++++EH GS+NAFTS E TN+YFDV
Sbjct: 97 VGYFCDPERLPGLAHFLEHMLFYASEKYPVEDDYSKYIAEHGGSTNAFTSRERTNFYFDV 156
Query: 154 SHEHLEGALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKH 213
++ L+ ALDRFAQFF+ PL RE+NAVDSE++KN+++D R+ QL+K + H
Sbjct: 157 NNSCLDDALDRFAQFFIKPLISPDATLREINAVDSENKKNLLSDPLRMSQLQKHFCSESH 216
Query: 214 PFSKFGTGNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVK 273
P+ KF TGN TL PN+EG+D +EL+KF++++YS+NLM + V G+ESLD+L NLV
Sbjct: 217 PYHKFSTGNLDTLLVNPNKEGLDTLEELIKFYNSHYSANLMQLVVYGKESLDNLQNLVEN 276
Query: 274 LFSEVENKNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHY 333
FS+V N F HP EHL+ + K VPIK+ L + +PI ++YK P Y
Sbjct: 277 KFSDVRNTGRESFSFHGHPCSSEHLQIIVKAVPIKEGHTLRIQWPITPNIQHYKEGPCKY 336
Query: 334 LGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILH 393
+ L+GHEG GSL LK+ GW +L + + + F FF + + LT+ G H+EDII
Sbjct: 337 VSRLVGHEGEGSLFYVLKNLGWAMSLYAWEGDWSYEFSFFNVVIQLTDVGYEHMEDIIGL 396
Query: 394 MFQYIQKLRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAE 453
+F+YI L+ G ++W+F E ++ + F ++DK P Y I+ + +P E+ L A
Sbjct: 397 LFRYIALLQTSGTRQWIFDELVAISEMGFHYRDKSPPIHYVVNISSNMQIFPPEDWLIAS 456
Query: 454 YLLEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKW 513
+ +F PD I+ +L+ L P+N R+ SK FEG+T+ TE WYGT Y EA+ +I+KW
Sbjct: 457 SVPSKFSPDAIQNILNDLTPDNARIFWESKKFEGQTNLTEPWYGTSYSVEAVTPSIIQKW 516
Query: 514 QNADLNGKFKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKAC 573
N +P N FIP++ + +E++ + +P +++ T S++W+K D FF PKA
Sbjct: 517 VNMAPMEDLHIPKPNIFIPSDLSLKNVEEKGS-FPCMLRKTMFSRVWYKPDTMFFTPKAY 575
Query: 574 LNFEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKG 633
+ +F P + P + ++ L+ D LN++AY A++AGL Y ++ + G +++ G
Sbjct: 576 VKMDFHCPLSNSSPESTVLTDMFTRLIMDYLNDFAYDAQIAGLYYFIRPSDTGFQITMVG 635
Query: 634 YNDKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEV 693
YNDK LL +I K+A FE+ RF +IKE ++ NF+ QP++ A YY L++ E
Sbjct: 636 YNDKMRTLLDTVIGKIAEFEVKVDRFAVIKETIIKDYENFKFRQPYEQAFYYCSLILEEQ 695
Query: 694 AWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHA 753
W DE A+ + L+ F+P+LL + IE GN+ A ++Q VEDTL
Sbjct: 696 TWAWDEKLAAVSHIEASDLQIFLPRLLGKTFIECYFAGNMEPGEAKSVIQHVEDTLFNAP 755
Query: 754 HT--KPLLPSQLVRYREVQLPDRGWFVYQQ---RNEVHNNCGIEIYYQTDMQSTSENMFL 808
+ K L PSQ + R V+L + Y ++ N I Y Q +N+ L
Sbjct: 756 ISFCKALPPSQHLTKRIVKLERGWRYYYPALCLNHQDEKNSSILHYIQIHQDDLKQNVLL 815
Query: 809 ELFCQIISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSE-KPPHYLESRVEAFL 867
+L + +P F+ LR+ EQLGYI R +G++GL+FIIQS K P L+ RVEAFL
Sbjct: 816 QLLALVAKQPAFHQLRSVEQLGYITVLTQRNDSGVRGLQFIIQSTVKDPSNLDDRVEAFL 875
Query: 868 ITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAY 927
E ++ M +E F+ ++ AL +L+K K + E A +W EI FDR EVA
Sbjct: 876 NMFEGTLYQMPDEEFKSNVNALIDMKLEKYKNIREESAFFWKEISEGTLKFDRKEAEVAA 935
Query: 928 LKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALP 987
L+ L KE++I+F+ + V+AP++ +S+ V G + + + P P
Sbjct: 936 LRDLNKEELIEFFNNHVKVNAPQKKILSIQVYG---------GLHSSEYEKIVHDEPQ-P 985
Query: 988 QPEVIQNMTEFKRGLPLFPLVK 1009
I ++ F+R PL+ K
Sbjct: 986 HSYQITDIFSFRRSRPLYGSFK 1007
>gb|EAZ40359.1| hypothetical protein OsJ_023842 [Oryza sativa (japonica
cultivar-group)]
Length = 1015
Score = 1044 bits (2700), Expect = 0.0, Method: Composition-based stats.
Identities = 367/982 (37%), Positives = 559/982 (56%), Gaps = 34/982 (3%)
Query: 51 GNHITKSPEDKREYRGLELANGIKVLLISDPTTDK-----------------SSAALDVH 93
IT+ DKR YR + L N ++ LL+SDP TDK ++A+++V
Sbjct: 37 DAEITRPRNDKRGYRRVVLPNALECLLVSDPDTDKVSVLSLAPSIGDVPGVLAAASMNVS 96
Query: 94 IGSLSDPPNIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDV 153
+G DP + GL+HF EHMLF ++KYP E++YS++++EH GS+NAFT E TN+YFDV
Sbjct: 97 VGYFCDPERLPGLAHFLEHMLFYASEKYPVEDDYSKYIAEHGGSTNAFTCRERTNFYFDV 156
Query: 154 SHEHLEGALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKH 213
++ L+ ALDRFAQFF+ PL RE+NAVDSE++KN+++D R+ QL+K + H
Sbjct: 157 NNSCLDDALDRFAQFFIKPLISPDATLREINAVDSENKKNLLSDPLRMSQLQKHFCSESH 216
Query: 214 PFSKFGTGNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVK 273
P+ KF TGN TL PN+EG+D +EL+KF++++YS+NLM + V G+ESLD+L NLV
Sbjct: 217 PYHKFSTGNLDTLLVNPNKEGLDTLEELIKFYNSHYSANLMQLVVYGKESLDNLQNLVEN 276
Query: 274 LFSEVENKNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHY 333
FS+V N F HP EHL+ + K VPIK+ L + +PI ++YK P Y
Sbjct: 277 KFSDVRNTGRESFSFHGHPCSSEHLQIIVKAVPIKEGHTLRIQWPITPNIQHYKEGPCKY 336
Query: 334 LGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILH 393
+ L+GHEG GSL LK+ GW +L + + + F FF + + LT+ G H+EDII
Sbjct: 337 VSRLVGHEGEGSLFYVLKNLGWAMSLYAWEGDWSYEFSFFNVVIQLTDVGYEHMEDIIGL 396
Query: 394 MFQYIQKLRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAE 453
+F+YI L+ G ++W+F E ++ + F ++DK P Y I+ + +P E+ L A
Sbjct: 397 LFRYIALLQTSGTRQWIFDELVAISEMGFHYRDKSPPIHYVVNISSNMQIFPPEDWLIAS 456
Query: 454 YLLEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKW 513
+ +F PD I+ +L+ L P+NVR+ SK FEG+T+ TE WYGT Y EA+ +I+KW
Sbjct: 457 SVPSKFSPDAIQNILNDLTPDNVRIFWESKKFEGQTNLTEPWYGTSYSVEAVTPSIIQKW 516
Query: 514 QNADLNGKFKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKAC 573
N +P N FIP++ + +E++ + +P +++ T S++W+K D FF PKA
Sbjct: 517 VNMAPMEDLHIPKPNIFIPSDLSLKNVEEKGS-FPCMLRKTMFSRVWYKPDTMFFTPKAY 575
Query: 574 LNFEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKG 633
+ +F P + P + ++ L+ D LN++AY A++AGL Y ++ + G +++ G
Sbjct: 576 VKMDFHCPLSNSSPESTVLTDMFTRLIMDYLNDFAYDAQIAGLYYFIRPSDTGFQITMVG 635
Query: 634 YNDKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEV 693
YNDK LL +I K+A FE+ RF +IKE ++ NF+ QP++ A YY L++ E
Sbjct: 636 YNDKMRTLLDTVIGKIAEFEVKVDRFAVIKETIIKDYENFKFRQPYEQAFYYCSLILEEQ 695
Query: 694 AWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHA 753
W DE A+ + L+ F+P+LL + IE GN+ A ++Q VEDTL
Sbjct: 696 TWAWDEKLAAVSHIEASDLQIFLPRLLGKTFIECYFAGNMEPGEAKSVIQHVEDTLFNAP 755
Query: 754 H--TKPLLPSQLVRYREVQLPDRGWFVYQQ---RNEVHNNCGIEIYYQTDMQSTSENMFL 808
K L PSQ + R V+L + Y ++ N I Y Q +N+ L
Sbjct: 756 ISFCKALPPSQHLTKRIVKLERGWRYYYPALCLNHQDEKNSSILHYIQIHQDDLKQNVLL 815
Query: 809 ELFCQIISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSE-KPPHYLESRVEAFL 867
+L + +P F+ LR+ EQLGYI R +G++GL+FIIQS K P L+ RVEAFL
Sbjct: 816 QLLALVAKQPAFHQLRSVEQLGYITVLTQRNDSGVRGLQFIIQSTVKDPSNLDDRVEAFL 875
Query: 868 ITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAY 927
E ++ M +E F+ ++ AL +L+K K + E A +W EI FDR EVA
Sbjct: 876 NMFEGTLYQMPDEEFKSNVNALIDMKLEKYKNIREESAFFWKEISEGTLKFDRKEAEVAA 935
Query: 928 LKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALP 987
L+ L KE++I+F+ + V+AP++ +S+ V G + + + P P
Sbjct: 936 LRDLNKEELIEFFNNHVKVNAPQKKILSIQVYG---------GLHSSEYEKIVHDEPQ-P 985
Query: 988 QPEVIQNMTEFKRGLPLFPLVK 1009
I ++ F+R PL+ K
Sbjct: 986 HSYQITDIFSFRRSRPLYGSFK 1007
>gb|EEH46323.1| insulin-degrading enzyme [Paracoccidioides brasiliensis Pb18]
Length = 1374
Score = 1043 bits (2698), Expect = 0.0, Method: Composition-based stats.
Identities = 367/999 (36%), Positives = 567/999 (56%), Gaps = 66/999 (6%)
Query: 44 NPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNI 103
A++R+ + + K D R YR + L N ++ LL+ DP TDK+SA+++V++G+ SD ++
Sbjct: 1 MTAVERLADVLEKPSVDDRSYRVIRLPNKLEALLVHDPDTDKASASVNVNVGNFSDDDDL 60
Query: 104 AGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEH------ 157
G++H EH LF+GT+KYPKEN Y+Q+L+ H+G SNA+T+ TNYYF+V+
Sbjct: 61 PGIAHAVEHALFMGTEKYPKENAYNQYLAAHSGYSNAYTAATETNYYFEVAATATSQSKS 120
Query: 158 --------------------------------------------LEGALDRFAQFFLCPL 173
L GALDRFAQFF+ PL
Sbjct: 121 SPEIPPATAAFPAEVEPLTDGLSKPPFPSIADSAASSSNDLVPPLYGALDRFAQFFIAPL 180
Query: 174 FDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQE 233
F ES DRE+ AVDSE++KN+ NDAWRL QL K+ NPKHP+ F TGN TL P
Sbjct: 181 FLESTLDRELRAVDSENKKNLQNDAWRLLQLNKSLSNPKHPYHHFSTGNLKTLRDGPQSR 240
Query: 234 GIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPE-HP 292
GI+VR E ++F+ YS+N M + VLG+ESLD+L V +LF++V+NK++P + + P
Sbjct: 241 GINVRDEFIRFYETNYSANRMKLVVLGQESLDELEGWVAELFADVKNKSLPQNRWDDVQP 300
Query: 293 FQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKS 352
F E+L+++ P+ D R+L + FP D Y+S P Y+ HLIGHEGPGS+L+ +K+
Sbjct: 301 FTSENLQKICFAKPVMDSRSLDMLFPYQDEDDMYESKPSKYISHLIGHEGPGSILAYIKA 360
Query: 353 KGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQ 412
KGW L G G F I+V LTE+GL H E+I+ +FQYI +++ P+EW+F
Sbjct: 361 KGWAYGLSAGALALCPGSALFTISVRLTEDGLKHYEEIVKVIFQYISLIKSRAPEEWIFD 420
Query: 413 ECKDLNAVAFRFKDKERPRGYTSKIAGILHY-YPLEEVLTAEYLLEEFRPDLIEMVLDKL 471
E K+L V F+FK K +TS ++ ++ YP E +L+ L+ +F I LD
Sbjct: 421 EMKNLAEVDFKFKQKSPASRFTSSLSSVMQKPYPREWLLSGPSLIRKFDEQAIRRGLDFF 480
Query: 472 RPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQ------NADLNGKFKLP 525
R +N + +VS+++ G D TE+WYGT+Y+ E I +++ + + + + + LP
Sbjct: 481 RADNFNIELVSQTYPGTWDSTEKWYGTEYRVEKISSDMLSQIERILQAPSNNPLPELHLP 540
Query: 526 TKNEFIPTNFEILPLEK-EATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAY 584
KNEF+PT E+ + E P LI++ + WFK+DD FF+PKA L +P Y
Sbjct: 541 HKNEFVPTRLEVEKKDVLEPAKKPTLIRNDDRVRAWFKKDDTFFVPKATLEITLRNPLVY 600
Query: 585 VDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKK 644
P + + + L++D L EY+Y AEL GL Y L +++G+ ++V GYNDK +LL+K
Sbjct: 601 ATPGNNVLTKIACGLIRDDLQEYSYDAELGGLDYSLSASVFGLEVTVSGYNDKMAVLLEK 660
Query: 645 IIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEAL 704
++ M F++ RF+I+K+ + +N +QP+ R L E AW ++L L
Sbjct: 661 VLHSMRDFKVKPDRFKIVKDRMTKGFSNAEFQQPYHQVGNVTRYLTAEKAWINEQLAAEL 720
Query: 705 DDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLV 764
+ + + AF PQLL + HIE L HGN+ K+ L + ++E T H +PL SQ
Sbjct: 721 EHIEAEDVAAFFPQLLRQTHIELLGHGNLYKEDVLKMADLIESTF----HARPLPKSQWH 776
Query: 765 RYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSE---NMFLELFCQIISEPCFN 821
R + P FVY++ + N I Y + S + LF Q+ +EP F+
Sbjct: 777 MRRNIIFPPGSNFVYEKTLKDPANVNHCIEYYLFVGSLMDPQLRAKSLLFGQLTNEPAFD 836
Query: 822 TLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEA 881
LRT+EQLGY+V+SG R A G R IIQS++ YLE+R++AFL ++++ MT E
Sbjct: 837 QLRTQEQLGYVVWSGVRYAATTLGYRVIIQSDRTNQYLETRIDAFLAGFAETLDKMTGEE 896
Query: 882 FQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYK 941
F+ H ++L +RL+K K L++E ++W I S+ ++F + T+ + L+K ++I++Y
Sbjct: 897 FEGHKRSLINKRLEKLKNLNSETGRFWSHIGSEYFDFLQHETDATIIAELSKAEMIEYYH 956
Query: 942 EMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINL 980
+ + +P R K+SVH++A+ V + +
Sbjct: 957 QYIDPSSPTRAKLSVHLVAQSQAHKAVGSDATTEERKAK 995
Searching..................................................done
Results from round 3
Score E
Sequences producing significant alignments: (bits) Value
Sequences used in model and found again:
ref|XP_001501085.1| PREDICTED: similar to insulin-degrading... 1308 0.0
ref|NP_004960.2| insulysin [Homo sapiens] >gi|55959215|emb|... 1278 0.0
ref|XP_507922.2| PREDICTED: insulysin isoform 4 [Pan troglo... 1277 0.0
ref|XP_001090249.1| PREDICTED: insulysin isoform 3 [Macaca ... 1274 0.0
ref|XP_001146582.1| PREDICTED: insulysin isoform 3 [Pan tro... 1266 0.0
ref|NP_001069317.1| insulin-degrading enzyme [Bos taurus] >... 1265 0.0
ref|XP_001506502.1| PREDICTED: similar to insulin-degrading... 1262 0.0
sp|P14735|IDE_HUMAN Insulin-degrading enzyme (Insulysin) (I... 1256 0.0
ref|NP_112419.2| insulin degrading enzyme [Mus musculus] >g... 1252 0.0
ref|NP_037291.1| insulin degrading enzyme [Rattus norvegicu... 1247 0.0
sp|Q9JHR7|IDE_MOUSE Insulin-degrading enzyme (Insulysin) (I... 1243 0.0
ref|XP_001090137.1| PREDICTED: insulysin isoform 2 [Macaca ... 1219 0.0
ref|XP_001146520.1| PREDICTED: insulysin isoform 2 [Pan tro... 1218 0.0
pdb|2G47|A Chain A, Crystal Structure Of Human Insulin-Degr... 1218 0.0
pdb|2JG4|A Chain A, Substrate-Free Ide Structure In Its Clo... 1217 0.0
ref|XP_534963.2| PREDICTED: similar to Insulin-degrading en... 1215 0.0
gb|EDL41785.1| insulin degrading enzyme [Mus musculus] 1208 0.0
pdb|2WBY|A Chain A, Crystal Structure Of Human Insulin-Degr... 1202 0.0
ref|NP_001082994.1| insulin-degrading enzyme [Danio rerio] ... 1195 0.0
dbj|BAF62161.1| insulin-degrading enzyme [Danio rerio] 1191 0.0
ref|XP_001847597.1| metalloprotease [Culex pipiens quinquef... 1092 0.0
ref|XP_001661876.1| metalloprotease [Aedes aegypti] >gi|108... 1090 0.0
ref|XP_971897.1| PREDICTED: similar to Insulin-degrading en... 1084 0.0
ref|XP_001603463.1| PREDICTED: similar to metalloprotease [... 1080 0.0
ref|NP_524182.2| Insulin degrading metalloproteinase CG5517... 1072 0.0
gb|AAO74689.1| RE17458p [Drosophila melanogaster] 1071 0.0
emb|CAO23586.1| unnamed protein product [Vitis vinifera] 1057 0.0
ref|XP_748141.1| a-pheromone processing metallopeptidase St... 1050 0.0
gb|EDP51051.1| a-pheromone processing metallopeptidase Ste2... 1049 0.0
ref|XP_001266332.1| a-pheromone processing metallopeptidase... 1049 0.0
ref|NP_181710.1| peptidase M16 family protein / insulinase ... 1048 0.0
dbj|BAE98754.1| putative zinc protease [Arabidopsis thaliana] 1047 0.0
sp|P22817|IDE_DROME Insulin-degrading enzyme (Insulysin) (I... 1047 0.0
ref|XP_001276340.1| a-pheromone processing metallopeptidase... 1047 0.0
ref|XP_311589.4| AGAP010351-PA [Anopheles gambiae str. PEST... 1044 0.0
gb|AAA28439.1| insulin-degrading enzyme 1043 0.0
emb|CAO23585.1| unnamed protein product [Vitis vinifera] 1037 0.0
ref|XP_681313.1| hypothetical protein AN8044.2 [Aspergillus... 1032 0.0
ref|XP_001397499.1| hypothetical protein An16g01860 [Asperg... 1031 0.0
gb|ABH09708.1| STE23-like protein [Penicillium marneffei] 1028 0.0
ref|XP_001629798.1| predicted protein [Nematostella vectens... 1027 0.0
ref|XP_001770543.1| predicted protein [Physcomitrella paten... 1027 0.0
ref|XP_001090017.1| PREDICTED: insulysin isoform 1 [Macaca ... 1025 0.0
ref|XP_001146439.1| PREDICTED: insulysin isoform 1 [Pan tro... 1025 0.0
ref|NP_001060044.1| Os07g0570300 [Oryza sativa (japonica cu... 1025 0.0
emb|CAC67408.1| insulin degrading enzyme [Solanum lycopersi... 1024 0.0
ref|XP_001674236.1| Hypothetical protein CBG09322 [Caenorha... 1023 0.0
ref|XP_532578.2| PREDICTED: similar to nardilysin (N-argini... 1021 0.0
emb|CAM16904.1| nardilysin, N-arginine dibasic convertase, ... 1021 0.0
ref|XP_001354132.1| GA18943-PA [Drosophila pseudoobscura] >... 1020 0.0
dbj|BAC79699.1| putative insulin degrading enzyme [Oryza sa... 1019 0.0
emb|CAA63696.1| NRD2 convertase [Rattus sp.] 1019 0.0
ref|XP_001105075.1| PREDICTED: similar to nardilysin (N-arg... 1018 0.0
ref|XP_513403.2| PREDICTED: nardilysin (N-arginine dibasic ... 1017 0.0
ref|NP_002516.2| nardilysin (N-arginine dibasic convertase)... 1015 0.0
gb|EAZ04397.1| hypothetical protein OsI_025629 [Oryza sativ... 1012 0.0
ref|XP_001491380.1| PREDICTED: similar to nardilysin (N-arg... 1012 0.0
gb|EAZ40359.1| hypothetical protein OsJ_023842 [Oryza sativ... 1011 0.0
gb|EEH46323.1| insulin-degrading enzyme [Paracoccidioides b... 1011 0.0
ref|XP_759404.1| hypothetical protein UM03257.1 [Ustilago m... 1011 0.0
ref|XP_001820380.1| hypothetical protein [Aspergillus oryza... 1010 0.0
emb|CAA63694.1| NRD2 convertase [Homo sapiens] 1010 0.0
gb|EAX06804.1| nardilysin (N-arginine dibasic convertase), ... 1009 0.0
ref|XP_956166.1| hypothetical protein NCU00481 [Neurospora ... 1008 0.0
ref|XP_588554.3| PREDICTED: similar to NRD1 protein isoform... 1007 0.0
ref|XP_001251077.1| PREDICTED: similar to NRD1 protein isof... 1007 0.0
ref|NP_001044429.1| Os01g0778800 [Oryza sativa (japonica cu... 1007 0.0
ref|XP_001543275.1| conserved hypothetical protein [Ajellom... 1007 0.0
ref|XP_001491299.1| PREDICTED: similar to nardilysin (N-arg... 1004 0.0
ref|XP_001140731.1| PREDICTED: nardilysin (N-arginine dibas... 1004 0.0
ref|XP_001761886.1| predicted protein [Physcomitrella paten... 1003 0.0
ref|XP_001242515.1| hypothetical protein CIMG_06411 [Coccid... 1003 0.0
gb|EAX06808.1| nardilysin (N-arginine dibasic convertase), ... 1003 0.0
gb|EDU43925.1| insulin-degrading enzyme [Pyrenophora tritic... 1003 0.0
gb|AAQ63406.1| nardilysin isoform [Homo sapiens] 1002 0.0
ref|NP_741542.1| F44E7.4b [Caenorhabditis elegans] >gi|2128... 1001 0.0
gb|EEH33611.1| A-factor-processing enzyme [Paracoccidioides... 1000 0.0
emb|CAB66104.1| protease-like protein [Arabidopsis thaliana] 997 0.0
ref|XP_505854.1| hypothetical protein [Yarrowia lipolytica]... 996 0.0
ref|NP_666262.2| nardilysin, N-arginine dibasic convertase,... 995 0.0
gb|AAH26832.1| Nardilysin, N-arginine dibasic convertase, N... 995 0.0
ref|NP_037125.1| n-arginine dibasic convertase 1 [Rattus no... 992 0.0
ref|NP_504514.2| F44E7.4c [Caenorhabditis elegans] >gi|2737... 992 0.0
ref|NP_741543.1| F44E7.4a [Caenorhabditis elegans] >gi|2291... 992 0.0
gb|EDL90380.1| nardilysin, N-arginine dibasic convertase 1 ... 992 0.0
ref|XP_859649.1| PREDICTED: similar to Nardilysin precursor... 991 0.0
ref|XP_001140946.1| PREDICTED: nardilysin (N-arginine dibas... 988 0.0
sp|O43847|NRDC_HUMAN Nardilysin precursor (N-arginine dibas... 987 0.0
ref|NP_001095132.1| nardilysin (N-arginine dibasic converta... 987 0.0
ref|XP_387087.1| hypothetical protein FG06911.1 [Gibberella... 986 0.0
ref|XP_001491329.1| PREDICTED: similar to nardilysin (N-arg... 986 0.0
ref|XP_001896776.1| insulin-degrading enzyme [Brugia malayi... 984 0.0
sp|Q5R4H6|NRDC_PONPY Nardilysin precursor (N-arginine dibas... 983 0.0
ref|XP_001908020.1| unnamed protein product [Podospora anse... 983 0.0
ref|XP_001218442.1| hypothetical protein ATEG_09820 [Asperg... 983 0.0
ref|NP_507226.2| Y70C5C.1 [Caenorhabditis elegans] >gi|5808... 982 0.0
emb|CAA63698.1| NRD1 convertase [Homo sapiens] 982 0.0
ref|XP_001801272.1| hypothetical protein SNOG_11020 [Phaeos... 981 0.0
ref|XP_001590112.1| hypothetical protein SS1G_08876 [Sclero... 981 0.0
ref|XP_001251166.1| PREDICTED: similar to NRD1 protein isof... 981 0.0
ref|XP_001251122.1| PREDICTED: similar to NRD1 protein isof... 981 0.0
gb|EAX06805.1| nardilysin (N-arginine dibasic convertase), ... 981 0.0
gb|AAH23786.1| Nrd1 protein [Mus musculus] 980 0.0
ref|XP_001491355.1| PREDICTED: similar to nardilysin (N-arg... 978 0.0
ref|XP_360292.2| hypothetical protein MGG_13149 [Magnaporth... 977 0.0
ref|ZP_01258854.1| peptidase, insulinase family protein [Vi... 975 0.0
ref|NP_798585.1| peptidase, insulinase family [Vibrio parah... 973 0.0
ref|ZP_02195786.1| peptidase, insulinase family protein [Vi... 972 0.0
ref|XP_001731164.1| hypothetical protein MGL_1347 [Malassez... 968 0.0
ref|ZP_01474320.1| hypothetical protein VEx2w_02003082 [Vib... 967 0.0
gb|EAY76035.1| hypothetical protein OsI_003882 [Oryza sativ... 965 0.0
ref|ZP_01987074.1| insulin-degrading enzyme [Vibrio harveyi... 965 0.0
gb|EAZ04398.1| hypothetical protein OsI_025630 [Oryza sativ... 964 0.0
gb|AAC39597.1| NRD convertase [Homo sapiens] 959 0.0
gb|EDN59292.1| metalloprotease [Saccharomyces cerevisiae YJ... 958 0.0
ref|NP_013493.2| Metalloprotease involved, with homolog Axl... 957 0.0
ref|XP_001763915.1| predicted protein [Physcomitrella paten... 951 0.0
ref|XP_001140801.1| PREDICTED: nardilysin (N-arginine dibas... 951 0.0
dbj|BAD52843.1| putative insulin degrading enzyme [Oryza sa... 950 0.0
ref|XP_001362262.1| PREDICTED: similar to nardilysin (N-arg... 950 0.0
ref|NP_001023928.1| F44E7.4d [Caenorhabditis elegans] >gi|5... 950 0.0
ref|NP_935232.1| peptidase, insulinase family [Vibrio vulni... 950 0.0
ref|XP_001362352.1| PREDICTED: similar to nardilysin (N-arg... 949 0.0
ref|NP_760850.1| Peptidase [Vibrio vulnificus CMCP6] >gi|27... 949 0.0
ref|NP_001038180.2| hypothetical protein LOC557565 [Danio r... 947 0.0
ref|XP_001391726.1| hypothetical protein An07g06490 [Asperg... 945 0.0
ref|ZP_01813161.1| peptidase, insulinase family protein [Vi... 944 0.0
ref|NP_984913.1| AER053Cp [Ashbya gossypii ATCC 10895] >gi|... 943 0.0
gb|EDN12518.1| peptidase, insulinase family [Vibrio cholera... 943 0.0
ref|ZP_01948940.1| peptidase, insulinase family [Vibrio cho... 943 0.0
ref|ZP_01978745.1| peptidase, insulinase family [Vibrio cho... 943 0.0
ref|NP_001026455.1| nardilysin (N-arginine dibasic converta... 942 0.0
ref|NP_231704.1| peptidase, insulinase family [Vibrio chole... 942 0.0
gb|EDN15048.1| peptidase, insulinase family [Vibrio cholera... 941 0.0
ref|XP_001646584.1| hypothetical protein Kpol_1055p83 [Vand... 941 0.0
ref|ZP_01956551.1| peptidase, insulinase family [Vibrio cho... 941 0.0
ref|YP_129176.1| putative peptidase, insulinase family [Pho... 941 0.0
ref|ZP_01981574.1| peptidase, insulinase family [Vibrio cho... 941 0.0
gb|EAZ49727.1| peptidase, insulinase family [Vibrio cholera... 940 0.0
ref|ZP_01482660.1| hypothetical protein VchoR_02001413 [Vib... 938 0.0
ref|XP_694205.1| PREDICTED: similar to Nardilysin, N-argini... 938 0.0
ref|ZP_01478796.1| hypothetical protein VchoM_02002058 [Vib... 938 0.0
ref|ZP_01706404.1| peptidase M16-like [Shewanella putrefaci... 938 0.0
ref|YP_001183975.1| peptidase M16 domain protein [Shewanell... 937 0.0
ref|YP_001366970.1| peptidase M16 domain protein [Shewanell... 937 0.0
ref|ZP_00990723.1| peptidase, insulinase family [Vibrio spl... 936 0.0
ref|YP_962945.1| peptidase M16 domain protein [Shewanella s... 936 0.0
ref|ZP_02157408.1| peptidase, M16 family protein [Shewanell... 935 0.0
ref|ZP_01485575.1| hypothetical protein VchoV5_02001802 [Vi... 935 0.0
ref|YP_869105.1| peptidase M16 domain protein [Shewanella s... 935 0.0
ref|YP_001555276.1| peptidase M16 domain protein [Shewanell... 935 0.0
ref|YP_737533.1| peptidase M16 domain protein [Shewanella s... 935 0.0
ref|YP_001051112.1| peptidase M16 domain protein [Shewanell... 935 0.0
ref|YP_733547.1| Insulysin [Shewanella sp. MR-4] >gi|113884... 935 0.0
ref|ZP_01222787.1| putative peptidase, insulinase family pr... 935 0.0
ref|YP_001446294.1| hypothetical protein VIBHAR_03118 [Vibr... 934 0.0
ref|YP_001094545.1| peptidase M16 domain protein [Shewanell... 934 0.0
ref|ZP_01844037.1| peptidase M16 domain protein [Shewanella... 933 0.0
ref|ZP_01064420.1| peptidase, insulinase family protein [Vi... 932 0.0
ref|NP_504532.1| C02G6.1 [Caenorhabditis elegans] >gi|12801... 932 0.0
emb|CAO77947.1| nardilysin, N-arginine dibasic convertase, ... 931 0.0
ref|NP_001118852.1| peptidase M16 family protein / insulina... 930 0.0
ref|ZP_01159983.1| putative peptidase, insulinase family pr... 930 0.0
ref|NP_718646.1| peptidase, M16 family [Shewanella oneidens... 929 0.0
ref|ZP_01866422.1| peptidase, insulinase family protein [Vi... 928 0.0
ref|YP_001761387.1| peptidase M16 domain protein [Shewanell... 928 0.0
ref|XP_001775609.1| predicted protein [Physcomitrella paten... 928 0.0
ref|ZP_01235782.1| putative peptidase, insulinase family pr... 926 0.0
ref|YP_205192.1| protease III [Vibrio fischeri ES114] >gi|5... 925 0.0
ref|YP_928038.1| peptidase, M16 family [Shewanella amazonen... 924 0.0
ref|XP_447076.1| unnamed protein product [Candida glabrata]... 924 0.0
ref|YP_001674877.1| peptidase M16 domain protein [Shewanell... 923 0.0
gb|EAZ40360.1| hypothetical protein OsJ_023843 [Oryza sativ... 923 0.0
ref|ZP_02135987.1| insulin-degrading enzyme [Vibrio fischer... 922 0.0
ref|YP_001473373.1| peptidase M16 domain protein [Shewanell... 920 0.0
ref|YP_001502447.1| peptidase M16 domain protein [Shewanell... 919 0.0
ref|XP_454175.1| unnamed protein product [Kluyveromyces lac... 919 0.0
ref|YP_001141698.1| insulinase [Aeromonas salmonicida subsp... 915 0.0
ref|XP_568105.1| insulin degrading enzyme [Cryptococcus neo... 915 0.0
ref|XP_773498.1| hypothetical protein CNBI1120 [Cryptococcu... 914 0.0
ref|XP_001760214.1| predicted protein [Physcomitrella paten... 911 0.0
ref|YP_562541.1| peptidase M16-like protein [Shewanella den... 907 0.0
ref|YP_856528.1| peptidase, insulinase family [Aeromonas hy... 906 0.0
ref|NP_593966.1| metallopeptidase [Schizosaccharomyces pomb... 903 0.0
ref|XP_001524140.1| conserved hypothetical protein [Loddero... 891 0.0
ref|XP_719241.1| a-factor pheromone maturation protease [Ca... 890 0.0
gb|EAY89915.1| hypothetical protein OsI_011148 [Oryza sativ... 889 0.0
ref|NP_001050040.1| Os03g0336300 [Oryza sativa (japonica cu... 888 0.0
gb|EAZ26839.1| hypothetical protein OsJ_010322 [Oryza sativ... 888 0.0
ref|YP_751350.1| peptidase M16 domain protein [Shewanella f... 885 0.0
ref|YP_436112.1| Secreted/periplasmic Zn-dependent peptidas... 884 0.0
ref|ZP_00827012.1| COG1025: Secreted/periplasmic Zn-depende... 883 0.0
ref|YP_001007484.1| protease III precursor [Yersinia entero... 883 0.0
dbj|BAF01167.1| hypothetical protein [Arabidopsis thaliana] 882 0.0
ref|NP_172173.2| metalloendopeptidase [Arabidopsis thaliana] 881 0.0
ref|ZP_00822919.1| COG1025: Secreted/periplasmic Zn-depende... 878 0.0
emb|CAO21314.1| unnamed protein product [Vitis vinifera] 877 0.0
ref|ZP_00830096.1| COG1025: Secreted/periplasmic Zn-depende... 875 0.0
ref|ZP_00834380.1| COG1025: Secreted/periplasmic Zn-depende... 874 0.0
ref|XP_001383768.2| hypothetical protein PICST_56651 [Pichi... 873 0.0
gb|EAY76045.1| hypothetical protein OsI_003892 [Oryza sativ... 871 0.0
ref|ZP_01101893.1| protease III precursor [gamma proteobact... 870 0.0
ref|YP_001719796.1| peptidase M16 domain protein [Yersinia ... 869 0.0
ref|NP_404633.1| protease III precursor [Yersinia pestis CO... 867 0.0
ref|XP_456547.1| hypothetical protein DEHA0A05214g [Debaryo... 866 0.0
ref|XP_001874916.1| predicted protein [Laccaria bicolor S23... 863 0.0
ref|YP_001480039.1| peptidase M16 domain protein [Serratia ... 860 0.0
ref|ZP_03838288.1| hypothetical protein CATC2_19978 [Citrob... 859 0.0
ref|YP_311808.1| protease III [Shigella sonnei Ss046] >gi|7... 858 0.0
ref|NP_755290.1| Protease III precursor [Escherichia coli C... 858 0.0
ref|YP_001744989.1| protease III [Escherichia coli SMS-3-5]... 858 0.0
ref|ZP_03833747.1| protease III precursor [Pectobacterium c... 857 0.0
ref|ZP_00713497.1| COG1025: Secreted/periplasmic Zn-depende... 857 0.0
ref|ZP_00923440.1| COG1025: Secreted/periplasmic Zn-depende... 857 0.0
ref|NP_708612.1| protease III [Shigella flexneri 2a str. 30... 856 0.0
ref|ZP_00714851.1| COG1025: Secreted/periplasmic Zn-depende... 856 0.0
ref|ZP_02999194.1| protease III [Escherichia coli 53638] >g... 856 0.0
ref|YP_001464156.1| protease III [Escherichia coli E24377A]... 856 0.0
ref|YP_542202.1| protease III precursor [Escherichia coli U... 856 0.0
ref|ZP_00920643.1| COG1025: Secreted/periplasmic Zn-depende... 856 0.0
ref|ZP_00712570.1| COG1025: Secreted/periplasmic Zn-depende... 856 0.0
ref|ZP_02644586.1| protease III [Salmonella enterica subsp.... 856 0.0
ref|NP_417298.1| protease III [Escherichia coli str. K-12 s... 855 0.0
ref|NP_461912.1| protease III [Salmonella typhimurium LT2] ... 855 0.0
ref|XP_001623609.1| predicted protein [Nematostella vectens... 855 0.0
gb|AAB40468.1| protease III precursor (pitrilysin) 855 0.0
ref|NP_311705.1| protease III [Escherichia coli O157:H7 str... 854 0.0
ref|ZP_02683828.1| protease III [Salmonella enterica subsp.... 854 0.0
pdb|1Q2L|A Chain A, Crystal Structure Of Pitrilysin 854 0.0
ref|YP_002807041.1| protease III [Escherichia sp. 1_1_43] >... 854 0.0
ref|YP_001573574.1| hypothetical protein SARI_04665 [Salmon... 854 0.0
ref|YP_001881438.1| protease III [Shigella boydii CDC 3083-... 854 0.0
ref|YP_217920.1| protease III [Salmonella enterica subsp. e... 854 0.0
ref|YP_409069.1| protease III [Shigella boydii Sb227] >gi|8... 853 0.0
ref|ZP_02343890.1| protease III [Salmonella enterica subsp.... 853 0.0
ref|ZP_02667694.1| protease III [Salmonella enterica subsp.... 853 0.0
ref|ZP_02651766.1| protease III precursor [Salmonella enter... 852 0.0
ref|YP_049101.1| protease III precursor [Erwinia carotovora... 852 0.0
ref|ZP_02349797.1| protease III precursor [Salmonella enter... 852 0.0
ref|ZP_02900475.1| protease III [Escherichia albertii TW076... 852 0.0
ref|YP_001177979.1| peptidase M16 domain protein [Enterobac... 852 0.0
ref|ZP_02704095.1| protease III [Salmonella enterica subsp.... 852 0.0
ref|NP_289373.1| protease III [Escherichia coli O157:H7 EDL... 851 0.0
ref|ZP_02832280.1| protease III [Salmonella enterica subsp.... 851 0.0
ref|ZP_02568654.1| protease III [Salmonella enterica subsp.... 849 0.0
ref|YP_404546.1| protease III [Shigella dysenteriae Sd197] ... 849 0.0
ref|ZP_02560586.1| protease III [Salmonella enterica subsp.... 849 0.0
ref|ZP_02697767.1| protease III [Salmonella enterica subsp.... 849 0.0
ref|XP_001599332.1| PREDICTED: similar to metalloendopeptid... 849 0.0
ref|ZP_01896589.1| putative peptidase, insulinase family [M... 848 0.0
ref|YP_001455683.1| hypothetical protein CKO_04186 [Citroba... 848 0.0
ref|XP_001486793.1| hypothetical protein PGUG_00170 [Pichia... 847 0.0
ref|NP_457388.1| protease III precursor (pitrilysin) [Salmo... 847 0.0
ref|ZP_01892098.1| Secreted/periplasmic Zn-dependent peptid... 846 0.0
ref|YP_959771.1| peptidase M16 domain protein [Marinobacter... 846 0.0
ref|XP_001833053.1| hypothetical protein CC1G_01115 [Coprin... 844 0.0
gb|EEH94306.1| protease III [Citrobacter sp. 30_2] 843 0.0
ref|YP_268860.1| zinc metallopeptidase, M16 family [Colwell... 842 0.0
ref|YP_001589894.1| hypothetical protein SPAB_03726 [Salmon... 841 0.0
ref|XP_001649937.1| metalloprotease [Aedes aegypti] >gi|108... 840 0.0
ref|YP_001336858.1| protease III [Klebsiella pneumoniae sub... 840 0.0
ref|ZP_01736964.1| Secreted/periplasmic Zn-dependent peptid... 839 0.0
ref|ZP_02679542.1| protease III [Salmonella enterica subsp.... 837 0.0
ref|YP_152017.1| protease III precursor (pitrilysin) [Salmo... 836 0.0
ref|YP_001908664.1| Protease 3 precursor (Pitrilysin) [Erwi... 835 0.0
ref|XP_001695185.1| insulinase-like metalloprotease [Chlamy... 834 0.0
ref|ZP_03829109.1| protease III precursor [Pectobacterium c... 834 0.0
gb|EAZ13744.1| hypothetical protein OsJ_003569 [Oryza sativ... 833 0.0
ref|ZP_01135442.1| zinc metallopeptidase, M16 family protei... 829 0.0
gb|AAF63132.1|AC011001_2 Putative N-arginine dibasic conver... 827 0.0
ref|ZP_01616823.1| Secreted/periplasmic Zn-dependent peptid... 827 0.0
ref|XP_396981.2| PREDICTED: similar to Insulin-degrading en... 826 0.0
ref|YP_001436619.1| hypothetical protein ESA_00488 [Enterob... 826 0.0
ref|NP_567049.2| peptidase M16 family protein / insulinase ... 820 0.0
ref|NP_001044431.1| Os01g0779100 [Oryza sativa (japonica cu... 818 0.0
ref|NP_927976.1| Protease III precursor (pitrilysin) [Photo... 814 0.0
ref|XP_966800.1| PREDICTED: similar to Nardilysin precursor... 809 0.0
ref|ZP_02959293.1| hypothetical protein PROSTU_01129 [Provi... 807 0.0
ref|XP_001031077.1| Insulysin, Insulin-degrading enzyme [Te... 805 0.0
ref|YP_339493.1| peptidase [Pseudoalteromonas haloplanktis ... 805 0.0
ref|ZP_01613408.1| protease III [Alteromonadales bacterium ... 803 0.0
ref|XP_001434792.1| hypothetical protein GSPATT00006701001 ... 802 0.0
ref|ZP_01223918.1| peptidase, insulinase family protein [ma... 801 0.0
ref|XP_001660612.1| metalloendopeptidase [Aedes aegypti] >g... 799 0.0
ref|ZP_01168295.1| zinc metallopeptidase, M16 family [Ocean... 799 0.0
ref|NP_504531.2| C02G6.2 [Caenorhabditis elegans] >gi|33620... 796 0.0
ref|YP_269852.1| zinc metallopeptidase, M16 family [Colwell... 795 0.0
ref|ZP_01114527.1| Secreted/periplasmic Zn-dependent peptid... 794 0.0
ref|XP_624437.2| PREDICTED: similar to Nardilysin precursor... 794 0.0
ref|XP_001449286.1| hypothetical protein GSPATT00016702001 ... 791 0.0
ref|YP_455654.1| protease III precursor [Sodalis glossinidi... 787 0.0
ref|ZP_01307403.1| Secreted/periplasmic Zn-dependent peptid... 787 0.0
emb|CAL51499.1| peptidase M16 family protein / insulinase f... 787 0.0
ref|XP_001194830.1| PREDICTED: similar to Insulin-degrading... 786 0.0
ref|XP_001844193.1| nardilysin [Culex pipiens quinquefascia... 784 0.0
ref|NP_649271.1| CG10588 CG10588-PA [Drosophila melanogaste... 782 0.0
gb|AAL15441.1| nardilysin [Homo sapiens] 782 0.0
ref|XP_795975.2| PREDICTED: similar to Insulin-degrading en... 782 0.0
ref|YP_575066.1| peptidase M16-like protein [Chromohalobact... 781 0.0
ref|ZP_03841633.1| pitrilysin [Proteus mirabilis ATCC 29906... 779 0.0
Sequences not found previously or not previously below threshold:
>ref|XP_001501085.1| PREDICTED: similar to insulin-degrading enzyme [Equus caballus]
Length = 1212
Score = 1308 bits (3385), Expect = 0.0, Method: Composition-based stats.
Identities = 1005/1019 (98%), Positives = 1012/1019 (99%)
Query: 1 MRYRLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED 60
MRYRLAWLLHPALPSTFRS LGARLPPPERL GFQKKTYSKMNNPAIKR+GNHI KSPED
Sbjct: 194 MRYRLAWLLHPALPSTFRSALGARLPPPERLSGFQKKTYSKMNNPAIKRLGNHIIKSPED 253
Query: 61 KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK 120
KREYRGL+LANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK
Sbjct: 254 KREYRGLQLANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK 313
Query: 121 YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD 180
YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD
Sbjct: 314 YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD 373
Query: 181 REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE 240
REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE
Sbjct: 374 REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE 433
Query: 241 LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ 300
LLKFHS YYSSNLMA+CVLGRESLDDLT+LVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ
Sbjct: 434 LLKFHSTYYSSNLMAICVLGRESLDDLTDLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ 493
Query: 301 LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV 360
LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV
Sbjct: 494 LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV 553
Query: 361 GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 420
GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV
Sbjct: 554 GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 613
Query: 421 AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI 480
AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVA+
Sbjct: 614 AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAV 673
Query: 481 VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL 540
VSKSFEGKTD TEEWYGTQY+QEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEIL L
Sbjct: 674 VSKSFEGKTDCTEEWYGTQYRQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILSL 733
Query: 541 EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL 600
EKEATPYP+LIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL
Sbjct: 734 EKEATPYPSLIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL 793
Query: 601 KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE 660
KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE
Sbjct: 794 KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE 853
Query: 661 IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 720
IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL
Sbjct: 854 IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 913
Query: 721 SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 780
SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ
Sbjct: 914 SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 973
Query: 781 QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 840
QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA
Sbjct: 974 QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 1033
Query: 841 NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL 900
NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL
Sbjct: 1034 NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL 1093
Query: 901 SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA 960
SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA
Sbjct: 1094 SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA 1153
Query: 961 REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL 1019
REMDSCPVVGEFPCQNDINLSQAP LPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL
Sbjct: 1154 REMDSCPVVGEFPCQNDINLSQAPGLPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL 1212
>ref|NP_004960.2| insulysin [Homo sapiens]
emb|CAI13670.1| insulin-degrading enzyme [Homo sapiens]
gb|AAH96337.1| Insulin-degrading enzyme [Homo sapiens]
gb|AAH96339.1| Insulin-degrading enzyme [Homo sapiens]
gb|AAH96336.1| Insulin-degrading enzyme [Homo sapiens]
gb|EAW50090.1| insulin-degrading enzyme, isoform CRA_a [Homo sapiens]
gb|EAW50091.1| insulin-degrading enzyme, isoform CRA_a [Homo sapiens]
Length = 1019
Score = 1278 bits (3308), Expect = 0.0, Method: Composition-based stats.
Identities = 1019/1019 (100%), Positives = 1019/1019 (100%)
Query: 1 MRYRLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED 60
MRYRLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED
Sbjct: 1 MRYRLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED 60
Query: 61 KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK 120
KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK
Sbjct: 61 KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK 120
Query: 121 YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD 180
YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD
Sbjct: 121 YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD 180
Query: 181 REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE 240
REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE
Sbjct: 181 REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE 240
Query: 241 LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ 300
LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ
Sbjct: 241 LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ 300
Query: 301 LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV 360
LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV
Sbjct: 301 LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV 360
Query: 361 GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 420
GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV
Sbjct: 361 GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 420
Query: 421 AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI 480
AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI
Sbjct: 421 AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI 480
Query: 481 VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL 540
VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL
Sbjct: 481 VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL 540
Query: 541 EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL 600
EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL
Sbjct: 541 EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL 600
Query: 601 KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE 660
KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE
Sbjct: 601 KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE 660
Query: 661 IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 720
IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL
Sbjct: 661 IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 720
Query: 721 SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 780
SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ
Sbjct: 721 SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 780
Query: 781 QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 840
QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA
Sbjct: 781 QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 840
Query: 841 NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL 900
NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL
Sbjct: 841 NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL 900
Query: 901 SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA 960
SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA
Sbjct: 901 SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA 960
Query: 961 REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL 1019
REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL
Sbjct: 961 REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL 1019
>ref|XP_507922.2| PREDICTED: insulysin isoform 4 [Pan troglodytes]
Length = 1019
Score = 1277 bits (3306), Expect = 0.0, Method: Composition-based stats.
Identities = 1018/1019 (99%), Positives = 1018/1019 (99%)
Query: 1 MRYRLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED 60
MRYRLAWLLHPAL STFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED
Sbjct: 1 MRYRLAWLLHPALSSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED 60
Query: 61 KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK 120
KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK
Sbjct: 61 KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK 120
Query: 121 YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD 180
YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD
Sbjct: 121 YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD 180
Query: 181 REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE 240
REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE
Sbjct: 181 REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE 240
Query: 241 LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ 300
LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ
Sbjct: 241 LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ 300
Query: 301 LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV 360
LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV
Sbjct: 301 LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV 360
Query: 361 GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 420
GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV
Sbjct: 361 GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 420
Query: 421 AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI 480
AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI
Sbjct: 421 AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI 480
Query: 481 VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL 540
VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL
Sbjct: 481 VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL 540
Query: 541 EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL 600
EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL
Sbjct: 541 EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL 600
Query: 601 KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE 660
KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE
Sbjct: 601 KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE 660
Query: 661 IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 720
IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL
Sbjct: 661 IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 720
Query: 721 SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 780
SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ
Sbjct: 721 SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 780
Query: 781 QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 840
QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA
Sbjct: 781 QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 840
Query: 841 NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL 900
NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL
Sbjct: 841 NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL 900
Query: 901 SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA 960
SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA
Sbjct: 901 SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA 960
Query: 961 REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL 1019
REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL
Sbjct: 961 REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL 1019
>ref|XP_001090249.1| PREDICTED: insulysin isoform 3 [Macaca mulatta]
Length = 1019
Score = 1274 bits (3297), Expect = 0.0, Method: Composition-based stats.
Identities = 1013/1019 (99%), Positives = 1016/1019 (99%)
Query: 1 MRYRLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED 60
MRYRLAWL HPALPSTFRSV GARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED
Sbjct: 1 MRYRLAWLRHPALPSTFRSVFGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED 60
Query: 61 KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK 120
KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK
Sbjct: 61 KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK 120
Query: 121 YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD 180
YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD
Sbjct: 121 YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD 180
Query: 181 REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE 240
REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE
Sbjct: 181 REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE 240
Query: 241 LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ 300
LLKFHS YYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENK+VPLPEFPEHPFQEEHLKQ
Sbjct: 241 LLKFHSTYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKSVPLPEFPEHPFQEEHLKQ 300
Query: 301 LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV 360
LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV
Sbjct: 301 LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV 360
Query: 361 GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 420
GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV
Sbjct: 361 GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 420
Query: 421 AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI 480
AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVA+
Sbjct: 421 AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAV 480
Query: 481 VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL 540
VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL
Sbjct: 481 VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL 540
Query: 541 EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL 600
EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL
Sbjct: 541 EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL 600
Query: 601 KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE 660
KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE
Sbjct: 601 KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE 660
Query: 661 IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 720
IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL
Sbjct: 661 IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 720
Query: 721 SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 780
SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ
Sbjct: 721 SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 780
Query: 781 QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 840
QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA
Sbjct: 781 QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 840
Query: 841 NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL 900
NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL
Sbjct: 841 NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL 900
Query: 901 SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA 960
SAECAKYWGEIISQQY+FDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA
Sbjct: 901 SAECAKYWGEIISQQYHFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA 960
Query: 961 REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL 1019
REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL
Sbjct: 961 REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL 1019
>ref|XP_001146582.1| PREDICTED: insulysin isoform 3 [Pan troglodytes]
Length = 1019
Score = 1266 bits (3276), Expect = 0.0, Method: Composition-based stats.
Identities = 995/1019 (97%), Positives = 1003/1019 (98%)
Query: 1 MRYRLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED 60
MRYRLAWLLHPAL STFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED
Sbjct: 1 MRYRLAWLLHPALSSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED 60
Query: 61 KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK 120
KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK
Sbjct: 61 KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK 120
Query: 121 YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD 180
YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD
Sbjct: 121 YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD 180
Query: 181 REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE 240
REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE
Sbjct: 181 REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE 240
Query: 241 LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ 300
LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ
Sbjct: 241 LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ 300
Query: 301 LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV 360
LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV
Sbjct: 301 LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV 360
Query: 361 GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 420
GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV
Sbjct: 361 GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 420
Query: 421 AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI 480
AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI
Sbjct: 421 AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI 480
Query: 481 VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL 540
VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL
Sbjct: 481 VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL 540
Query: 541 EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL 600
EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFS + Y DPLHCNM YL++ LL
Sbjct: 541 EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSRYIYADPLHCNMTYLFIRLL 600
Query: 601 KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE 660
KD L EY YAA L+GLSY + + + + LSVKGYNDKQPILLKKIIEKMATFEIDEKRFE
Sbjct: 601 KDDLKEYTYAARLSGLSYGIASGMNAILLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE 660
Query: 661 IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 720
IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL
Sbjct: 661 IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 720
Query: 721 SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 780
SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ
Sbjct: 721 SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 780
Query: 781 QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 840
QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA
Sbjct: 781 QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 840
Query: 841 NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL 900
NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL
Sbjct: 841 NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL 900
Query: 901 SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA 960
SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA
Sbjct: 901 SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA 960
Query: 961 REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL 1019
REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL
Sbjct: 961 REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL 1019
>ref|NP_001069317.1| insulin-degrading enzyme [Bos taurus]
sp|Q24K02|IDE_BOVIN Insulin-degrading enzyme (Insulysin) (Insulinase) (Insulin protease)
gb|AAI14106.1| Similar to Insulin-degrading enzyme (Insulysin) (Insulinase) (Insulin
protease) [Bos taurus]
Length = 1019
Score = 1265 bits (3274), Expect = 0.0, Method: Composition-based stats.
Identities = 1007/1019 (98%), Positives = 1011/1019 (99%)
Query: 1 MRYRLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED 60
MRYRLAWLLH ALPSTFRSVLGARLPP ERLCGFQKKTYSKMNNPAIKRIG+HI KS ED
Sbjct: 1 MRYRLAWLLHSALPSTFRSVLGARLPPSERLCGFQKKTYSKMNNPAIKRIGHHIIKSHED 60
Query: 61 KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK 120
KREYRGLELANGIKVLL+SDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK
Sbjct: 61 KREYRGLELANGIKVLLVSDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK 120
Query: 121 YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD 180
YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD
Sbjct: 121 YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD 180
Query: 181 REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE 240
REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE
Sbjct: 181 REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE 240
Query: 241 LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ 300
LLKFHS YYSSNLMA+CVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ
Sbjct: 241 LLKFHSTYYSSNLMAICVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ 300
Query: 301 LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV 360
LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV
Sbjct: 301 LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV 360
Query: 361 GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 420
GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV
Sbjct: 361 GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 420
Query: 421 AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI 480
AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI
Sbjct: 421 AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI 480
Query: 481 VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL 540
VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLP KNEFIPTNFEIL L
Sbjct: 481 VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPMKNEFIPTNFEILSL 540
Query: 541 EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL 600
EKEATPYP+LIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL
Sbjct: 541 EKEATPYPSLIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL 600
Query: 601 KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE 660
KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE
Sbjct: 601 KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE 660
Query: 661 IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 720
IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL
Sbjct: 661 IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 720
Query: 721 SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 780
SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ
Sbjct: 721 SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 780
Query: 781 QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 840
QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA
Sbjct: 781 QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 840
Query: 841 NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL 900
NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL
Sbjct: 841 NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL 900
Query: 901 SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA 960
SAECAKYWGEIISQQYNFDRDN EVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA
Sbjct: 901 SAECAKYWGEIISQQYNFDRDNIEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA 960
Query: 961 REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL 1019
REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL
Sbjct: 961 REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL 1019
>ref|XP_001506502.1| PREDICTED: similar to insulin-degrading enzyme [Ornithorhynchus
anatinus]
Length = 1301
Score = 1262 bits (3266), Expect = 0.0, Method: Composition-based stats.
Identities = 944/1017 (92%), Positives = 971/1017 (95%), Gaps = 3/1017 (0%)
Query: 4 RLAWLLHPALPSTFRSVLGARLPPPERLCGF-QKKTYSKMNNPAIKRIGNHITKSPEDKR 62
R A FRS+ R R Q+ +Y KM++ A+KRI N+I KSPEDKR
Sbjct: 287 RAPLTAVGA--VAFRSLSQTRPVANARSSFSFQRYSYGKMDHSAVKRIVNNIIKSPEDKR 344
Query: 63 EYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKKYP 122
EYRGLELANGIK +LISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKKYP
Sbjct: 345 EYRGLELANGIKAILISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKKYP 404
Query: 123 KENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKDRE 182
KENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKDRE
Sbjct: 405 KENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKDRE 464
Query: 183 VNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQELL 242
VNAVDSEHEKNVMNDAWRLFQLEKATGNP HPFSKFGTGNKYTLETRP +EGIDVRQELL
Sbjct: 465 VNAVDSEHEKNVMNDAWRLFQLEKATGNPNHPFSKFGTGNKYTLETRPTKEGIDVRQELL 524
Query: 243 KFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQLY 302
KFHS YYSSNLMA+CVLGRESLD+LT+LVVKLFSEVENKNVPLPEFPEHPFQE HL+Q+Y
Sbjct: 525 KFHSTYYSSNLMAICVLGRESLDELTSLVVKLFSEVENKNVPLPEFPEHPFQEHHLRQIY 584
Query: 303 KIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLVGG 362
K+VPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELK+KGWVNTLVGG
Sbjct: 585 KVVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKAKGWVNTLVGG 644
Query: 363 QKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAVAF 422
QKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLR EGPQEWVFQECKDLNAVAF
Sbjct: 645 QKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRTEGPQEWVFQECKDLNAVAF 704
Query: 423 RFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAIVS 482
RFKDKERPRGYTSK+ G+LHYYPLEEVL AEYLLEEFRPDLIEMVLDKLRPENVRVAIVS
Sbjct: 705 RFKDKERPRGYTSKLGGMLHYYPLEEVLAAEYLLEEFRPDLIEMVLDKLRPENVRVAIVS 764
Query: 483 KSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPLEK 542
KSFEGKTD+TEEWYGTQYKQEAI DEVIKKWQNADLNGKFKLP KNEFIP+NFEIL LEK
Sbjct: 765 KSFEGKTDQTEEWYGTQYKQEAISDEVIKKWQNADLNGKFKLPMKNEFIPSNFEILQLEK 824
Query: 543 EATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELLKD 602
EA YPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELLKD
Sbjct: 825 EAPSYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELLKD 884
Query: 603 SLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFEII 662
SLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKI+EKMATFEIDEKRFEII
Sbjct: 885 SLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIVEKMATFEIDEKRFEII 944
Query: 663 KEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSR 722
KEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSR
Sbjct: 945 KEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSR 1004
Query: 723 LHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQR 782
LHIEALLHGNITKQAALG+MQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQR
Sbjct: 1005 LHIEALLHGNITKQAALGVMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQR 1064
Query: 783 NEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRANG 842
NEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRANG
Sbjct: 1065 NEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRANG 1124
Query: 843 IQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKLSA 902
IQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKLSA
Sbjct: 1125 IQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKLSA 1184
Query: 903 ECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLARE 962
ECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDII+FYKEMLAV+APRRHKVSVHVLARE
Sbjct: 1185 ECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIRFYKEMLAVEAPRRHKVSVHVLARE 1244
Query: 963 MDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL 1019
MDSCPVVGEFPCQND+NL+ APALPQPEVI+NMT FKR LPLFPLVKPHIN MAAKL
Sbjct: 1245 MDSCPVVGEFPCQNDVNLAAAPALPQPEVIENMTAFKRSLPLFPLVKPHINLMAAKL 1301
>sp|P14735|IDE_HUMAN Insulin-degrading enzyme (Insulysin) (Insulinase) (Insulin protease)
gb|AAA52712.1| insulin-degrading enzyme
Length = 1019
Score = 1256 bits (3250), Expect = 0.0, Method: Composition-based stats.
Identities = 1013/1019 (99%), Positives = 1014/1019 (99%)
Query: 1 MRYRLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED 60
MRYRLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED
Sbjct: 1 MRYRLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED 60
Query: 61 KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK 120
KREYRGLELANGIKVLL+SDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK
Sbjct: 61 KREYRGLELANGIKVLLMSDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK 120
Query: 121 YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD 180
YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD
Sbjct: 121 YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD 180
Query: 181 REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE 240
REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE
Sbjct: 181 REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE 240
Query: 241 LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ 300
LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ
Sbjct: 241 LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ 300
Query: 301 LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV 360
LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV
Sbjct: 301 LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV 360
Query: 361 GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 420
GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV
Sbjct: 361 GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 420
Query: 421 AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI 480
AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI
Sbjct: 421 AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI 480
Query: 481 VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL 540
VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL
Sbjct: 481 VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL 540
Query: 541 EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL 600
EKEATPYPALIKDT MSKLWFKQDDK PKACLNFEFFSPFAYVDPLHCNMAYLYLELL
Sbjct: 541 EKEATPYPALIKDTVMSKLWFKQDDKKKKPKACLNFEFFSPFAYVDPLHCNMAYLYLELL 600
Query: 601 KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE 660
KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE
Sbjct: 601 KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE 660
Query: 661 IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 720
IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL
Sbjct: 661 IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 720
Query: 721 SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 780
SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ
Sbjct: 721 SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 780
Query: 781 QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 840
QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA
Sbjct: 781 QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 840
Query: 841 NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL 900
NGIQ LRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL
Sbjct: 841 NGIQSLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL 900
Query: 901 SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA 960
SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA
Sbjct: 901 SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA 960
Query: 961 REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL 1019
REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL
Sbjct: 961 REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL 1019
>ref|NP_112419.2| insulin degrading enzyme [Mus musculus]
gb|AAH41675.1| Insulin degrading enzyme [Mus musculus]
Length = 1019
Score = 1252 bits (3240), Expect = 0.0, Method: Composition-based stats.
Identities = 970/1019 (95%), Positives = 995/1019 (97%)
Query: 1 MRYRLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED 60
MR L WLLHPALP T RS+LGAR PP +RLCGF K+TYS M+NPAI+RI + I KSPED
Sbjct: 1 MRNGLVWLLHPALPGTLRSILGARPPPAKRLCGFPKQTYSTMSNPAIQRIEDQIVKSPED 60
Query: 61 KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK 120
KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNI GLSHFCEHMLFLGTKK
Sbjct: 61 KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIPGLSHFCEHMLFLGTKK 120
Query: 121 YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD 180
YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFD SCKD
Sbjct: 121 YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDASCKD 180
Query: 181 REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE 240
REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVR+E
Sbjct: 181 REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVREE 240
Query: 241 LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ 300
LLKFHS YYSSNLMA+CVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHL+Q
Sbjct: 241 LLKFHSTYYSSNLMAICVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLRQ 300
Query: 301 LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV 360
LYKIVPIKDIRNLYVTFPIPDLQ+YYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV
Sbjct: 301 LYKIVPIKDIRNLYVTFPIPDLQQYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV 360
Query: 361 GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 420
GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV
Sbjct: 361 GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 420
Query: 421 AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI 480
AFRFKDKERPRGYTSKIAG LHYYPL VLTAEYLLEEFRPDLI+MVLDKLRPENVRVAI
Sbjct: 421 AFRFKDKERPRGYTSKIAGKLHYYPLNGVLTAEYLLEEFRPDLIDMVLDKLRPENVRVAI 480
Query: 481 VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL 540
VSKSFEGKTDRTE+WYGTQYKQEAIP+++I+KWQNADLNGKFKLPTKNEFIPTNFEIL L
Sbjct: 481 VSKSFEGKTDRTEQWYGTQYKQEAIPEDIIQKWQNADLNGKFKLPTKNEFIPTNFEILSL 540
Query: 541 EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL 600
EK+ATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL
Sbjct: 541 EKDATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL 600
Query: 601 KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE 660
KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKI EKMATFEID+KRFE
Sbjct: 601 KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKITEKMATFEIDKKRFE 660
Query: 661 IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 720
IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL
Sbjct: 661 IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 720
Query: 721 SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 780
SRLHIEALLHGNITKQAALG+MQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ
Sbjct: 721 SRLHIEALLHGNITKQAALGVMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 780
Query: 781 QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 840
QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA
Sbjct: 781 QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 840
Query: 841 NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL 900
NGIQGLRFIIQSEKPPHYLESRVEAFLITMEK+IEDMTEEAFQKHIQALAIRRLDKPKKL
Sbjct: 841 NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKAIEDMTEEAFQKHIQALAIRRLDKPKKL 900
Query: 901 SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA 960
SAECAKYWGEIISQQYN+DRDN EVAYLKTLTK+DII+FY+EMLAVDAPRRHKVSVHVLA
Sbjct: 901 SAECAKYWGEIISQQYNYDRDNIEVAYLKTLTKDDIIRFYQEMLAVDAPRRHKVSVHVLA 960
Query: 961 REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL 1019
REMDSCPVVGEFP QNDINLS+AP LPQPEVI NMTEFKRGLPLFPLVKPHINFMAAKL
Sbjct: 961 REMDSCPVVGEFPSQNDINLSEAPPLPQPEVIHNMTEFKRGLPLFPLVKPHINFMAAKL 1019
>ref|NP_037291.1| insulin degrading enzyme [Rattus norvegicus]
sp|P35559|IDE_RAT Insulin-degrading enzyme (Insulysin) (Insulinase) (Insulin protease)
emb|CAA47689.1| insulin-degrading enzyme [Rattus norvegicus]
gb|EDM13196.1| insulin degrading enzyme [Rattus norvegicus]
Length = 1019
Score = 1247 bits (3227), Expect = 0.0, Method: Composition-based stats.
Identities = 973/1019 (95%), Positives = 995/1019 (97%)
Query: 1 MRYRLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED 60
MR L WLLHPALPST S+LGAR PP +RLCGF K+ YS MNNPAI+RI +HI KSPED
Sbjct: 1 MRNGLVWLLHPALPSTLHSILGARPPPVKRLCGFPKQIYSTMNNPAIQRIEDHIVKSPED 60
Query: 61 KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK 120
KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNI GLSHFCEHMLFLGTKK
Sbjct: 61 KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIPGLSHFCEHMLFLGTKK 120
Query: 121 YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD 180
YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFD SCKD
Sbjct: 121 YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDASCKD 180
Query: 181 REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE 240
REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVR+E
Sbjct: 181 REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVREE 240
Query: 241 LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ 300
LLKFHS YYSSNLMA+CVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ
Sbjct: 241 LLKFHSTYYSSNLMAICVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ 300
Query: 301 LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV 360
LYKIVPIKDIRNLYVTFPIPDLQ+YYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV
Sbjct: 301 LYKIVPIKDIRNLYVTFPIPDLQQYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV 360
Query: 361 GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 420
GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV
Sbjct: 361 GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 420
Query: 421 AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI 480
AFRFKDKERPRGYTSKIAG LHYYPL VLTAEYLLEEFRPDLI+MVLDKLRPENVRVAI
Sbjct: 421 AFRFKDKERPRGYTSKIAGKLHYYPLNGVLTAEYLLEEFRPDLIDMVLDKLRPENVRVAI 480
Query: 481 VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL 540
VSKSFEGKTDRTE+WYGTQYKQEAIP++VI+KWQNADLNGKFKLPTKNEFIPTNFEIL L
Sbjct: 481 VSKSFEGKTDRTEQWYGTQYKQEAIPEDVIQKWQNADLNGKFKLPTKNEFIPTNFEILAL 540
Query: 541 EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL 600
EK+ATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL
Sbjct: 541 EKDATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL 600
Query: 601 KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE 660
KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKI EKMATFEID+KRFE
Sbjct: 601 KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKITEKMATFEIDKKRFE 660
Query: 661 IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 720
IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL
Sbjct: 661 IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 720
Query: 721 SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 780
SRLHIEALLHGNITKQAALG+MQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ
Sbjct: 721 SRLHIEALLHGNITKQAALGVMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 780
Query: 781 QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 840
+RNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA
Sbjct: 781 RRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 840
Query: 841 NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL 900
NGIQGLRFIIQSEKPPHYLESRVEAFLITMEK+IEDMTEEAFQKHIQALAIRRLDKPKKL
Sbjct: 841 NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKAIEDMTEEAFQKHIQALAIRRLDKPKKL 900
Query: 901 SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA 960
SAECAKYWGEIISQQYN+DRDN EVAYLKTL+K+DIIKFYKEMLAVDAPRRHKVSVHVLA
Sbjct: 901 SAECAKYWGEIISQQYNYDRDNIEVAYLKTLSKDDIIKFYKEMLAVDAPRRHKVSVHVLA 960
Query: 961 REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL 1019
REMDSCPVVGEFP QNDINLS+AP LPQPEVI NMTEFKRGLPLFPLVKPHINFMAAKL
Sbjct: 961 REMDSCPVVGEFPSQNDINLSEAPPLPQPEVIHNMTEFKRGLPLFPLVKPHINFMAAKL 1019
>sp|Q9JHR7|IDE_MOUSE Insulin-degrading enzyme (Insulysin) (Insulinase) (Insulin protease)
emb|CAC01233.1| insulin degrading enzyme [Mus musculus]
Length = 1019
Score = 1243 bits (3218), Expect = 0.0, Method: Composition-based stats.
Identities = 968/1019 (94%), Positives = 993/1019 (97%)
Query: 1 MRYRLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED 60
MR L WLLHPALP T RS+LGAR PP +RLCGF K+TYS M+NPAI+RI + I KSPED
Sbjct: 1 MRNGLVWLLHPALPGTLRSILGARPPPAKRLCGFPKQTYSTMSNPAIQRIEDQIVKSPED 60
Query: 61 KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK 120
KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNI GLSHFCEHMLFLGTKK
Sbjct: 61 KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIPGLSHFCEHMLFLGTKK 120
Query: 121 YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD 180
YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPL D SCKD
Sbjct: 121 YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLLDASCKD 180
Query: 181 REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE 240
REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVR+E
Sbjct: 181 REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVREE 240
Query: 241 LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ 300
LLKFHS YYSSNLMA+CVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHL+Q
Sbjct: 241 LLKFHSTYYSSNLMAICVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLRQ 300
Query: 301 LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV 360
LYKIVPIKDIRNLYVTFPIPDLQ+YYKSNPG+YLGHLIGHEGPGSLLSELKSKGWVNTLV
Sbjct: 301 LYKIVPIKDIRNLYVTFPIPDLQQYYKSNPGYYLGHLIGHEGPGSLLSELKSKGWVNTLV 360
Query: 361 GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 420
GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV
Sbjct: 361 GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 420
Query: 421 AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI 480
AFRFKDKERPRGYTSKIAG LHYYPL VLTAEYLLEEFRPDLI+MVLDKLRPENVRVAI
Sbjct: 421 AFRFKDKERPRGYTSKIAGKLHYYPLNGVLTAEYLLEEFRPDLIDMVLDKLRPENVRVAI 480
Query: 481 VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL 540
VSKSFEGKTDRTE+WYGTQYKQEAIP++VI+KWQNADLNGKFKLPTKNEFIPTNFEIL L
Sbjct: 481 VSKSFEGKTDRTEQWYGTQYKQEAIPEDVIQKWQNADLNGKFKLPTKNEFIPTNFEILSL 540
Query: 541 EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL 600
EK+ATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL
Sbjct: 541 EKDATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL 600
Query: 601 KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE 660
KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVK YNDKQPILLKKI EKMATFEID+KRFE
Sbjct: 601 KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKRYNDKQPILLKKITEKMATFEIDKKRFE 660
Query: 661 IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 720
IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL
Sbjct: 661 IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 720
Query: 721 SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 780
SRLHIEALLHGNITKQAALG+MQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ
Sbjct: 721 SRLHIEALLHGNITKQAALGVMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 780
Query: 781 QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 840
QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA
Sbjct: 781 QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 840
Query: 841 NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL 900
NGIQGLRFIIQSEKPPHYLESRVEAFLITMEK+IEDMTEEAFQKHIQALAIRRLDKPKKL
Sbjct: 841 NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKAIEDMTEEAFQKHIQALAIRRLDKPKKL 900
Query: 901 SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA 960
SAECAKYWGEIISQQYN+DRDN EVAYLKTLTK+DII+FY+EMLAVDAPRRHKVSVHVLA
Sbjct: 901 SAECAKYWGEIISQQYNYDRDNIEVAYLKTLTKDDIIRFYQEMLAVDAPRRHKVSVHVLA 960
Query: 961 REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL 1019
REMDSCPVVGEFP QNDINLS+AP LPQPEVI NMTEFKRGLPLFPLVKPHINFMAAKL
Sbjct: 961 REMDSCPVVGEFPSQNDINLSEAPPLPQPEVIHNMTEFKRGLPLFPLVKPHINFMAAKL 1019
>ref|XP_001090137.1| PREDICTED: insulysin isoform 2 [Macaca mulatta]
Length = 978
Score = 1219 bits (3154), Expect = 0.0, Method: Composition-based stats.
Identities = 974/978 (99%), Positives = 977/978 (99%)
Query: 42 MNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPP 101
MNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPP
Sbjct: 1 MNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPP 60
Query: 102 NIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGA 161
NIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGA
Sbjct: 61 NIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGA 120
Query: 162 LDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTG 221
LDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTG
Sbjct: 121 LDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTG 180
Query: 222 NKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENK 281
NKYTLETRPNQEGIDVRQELLKFHS YYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENK
Sbjct: 181 NKYTLETRPNQEGIDVRQELLKFHSTYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENK 240
Query: 282 NVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHE 341
+VPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHE
Sbjct: 241 SVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHE 300
Query: 342 GPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKL 401
GPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKL
Sbjct: 301 GPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKL 360
Query: 402 RAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRP 461
RAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRP
Sbjct: 361 RAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRP 420
Query: 462 DLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGK 521
DLIEMVLDKLRPENVRVA+VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGK
Sbjct: 421 DLIEMVLDKLRPENVRVAVVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGK 480
Query: 522 FKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSP 581
FKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSP
Sbjct: 481 FKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSP 540
Query: 582 FAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPIL 641
FAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPIL
Sbjct: 541 FAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPIL 600
Query: 642 LKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELK 701
LKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELK
Sbjct: 601 LKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELK 660
Query: 702 EALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPS 761
EALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPS
Sbjct: 661 EALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPS 720
Query: 762 QLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFN 821
QLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFN
Sbjct: 721 QLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFN 780
Query: 822 TLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEA 881
TLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEA
Sbjct: 781 TLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEA 840
Query: 882 FQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYK 941
FQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQY+FDRDNTEVAYLKTLTKEDIIKFYK
Sbjct: 841 FQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYHFDRDNTEVAYLKTLTKEDIIKFYK 900
Query: 942 EMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRG 1001
EMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRG
Sbjct: 901 EMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRG 960
Query: 1002 LPLFPLVKPHINFMAAKL 1019
LPLFPLVKPHINFMAAKL
Sbjct: 961 LPLFPLVKPHINFMAAKL 978
>ref|XP_001146520.1| PREDICTED: insulysin isoform 2 [Pan troglodytes]
gb|EAW50093.1| insulin-degrading enzyme, isoform CRA_c [Homo sapiens]
Length = 978
Score = 1218 bits (3153), Expect = 0.0, Method: Composition-based stats.
Identities = 978/978 (100%), Positives = 978/978 (100%)
Query: 42 MNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPP 101
MNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPP
Sbjct: 1 MNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPP 60
Query: 102 NIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGA 161
NIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGA
Sbjct: 61 NIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGA 120
Query: 162 LDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTG 221
LDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTG
Sbjct: 121 LDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTG 180
Query: 222 NKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENK 281
NKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENK
Sbjct: 181 NKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENK 240
Query: 282 NVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHE 341
NVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHE
Sbjct: 241 NVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHE 300
Query: 342 GPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKL 401
GPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKL
Sbjct: 301 GPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKL 360
Query: 402 RAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRP 461
RAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRP
Sbjct: 361 RAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRP 420
Query: 462 DLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGK 521
DLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGK
Sbjct: 421 DLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGK 480
Query: 522 FKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSP 581
FKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSP
Sbjct: 481 FKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSP 540
Query: 582 FAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPIL 641
FAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPIL
Sbjct: 541 FAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPIL 600
Query: 642 LKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELK 701
LKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELK
Sbjct: 601 LKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELK 660
Query: 702 EALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPS 761
EALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPS
Sbjct: 661 EALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPS 720
Query: 762 QLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFN 821
QLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFN
Sbjct: 721 QLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFN 780
Query: 822 TLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEA 881
TLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEA
Sbjct: 781 TLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEA 840
Query: 882 FQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYK 941
FQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYK
Sbjct: 841 FQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYK 900
Query: 942 EMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRG 1001
EMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRG
Sbjct: 901 EMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRG 960
Query: 1002 LPLFPLVKPHINFMAAKL 1019
LPLFPLVKPHINFMAAKL
Sbjct: 961 LPLFPLVKPHINFMAAKL 978
>pdb|2G47|A Chain A, Crystal Structure Of Human Insulin-Degrading Enzyme In
Complex With Amyloid-Beta (1-40)
pdb|2G47|B Chain B, Crystal Structure Of Human Insulin-Degrading Enzyme In
Complex With Amyloid-Beta (1-40)
pdb|2G48|A Chain A, Crystal Structure Of Human Insulin-Degrading Enzyme In
Complex With Amylin
pdb|2G48|B Chain B, Crystal Structure Of Human Insulin-Degrading Enzyme In
Complex With Amylin
pdb|2G49|A Chain A, Crystal Structure Of Human Insulin-Degrading Enzyme In
Complex With Glucagon
pdb|2G49|B Chain B, Crystal Structure Of Human Insulin-Degrading Enzyme In
Complex With Glucagon
pdb|2G54|A Chain A, Crystal Structure Of Zn-Bound Human Insulin-Degrading Enzyme
In Complex With Insulin B Chain
pdb|2G54|B Chain B, Crystal Structure Of Zn-Bound Human Insulin-Degrading Enzyme
In Complex With Insulin B Chain
pdb|2G56|A Chain A, Crystal Structure Of Human Insulin-Degrading Enzyme In
Complex With Insulin B Chain
pdb|2G56|B Chain B, Crystal Structure Of Human Insulin-Degrading Enzyme In
Complex With Insulin B Chain
pdb|2JBU|A Chain A, Crystal Structure Of Human Insulin Degrading Enzyme
Complexed With Co-Purified Peptides.
pdb|2JBU|B Chain B, Crystal Structure Of Human Insulin Degrading Enzyme
Complexed With Co-Purified Peptides.
Length = 990
Score = 1218 bits (3152), Expect = 0.0, Method: Composition-based stats.
Identities = 977/979 (99%), Positives = 978/979 (99%)
Query: 41 KMNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDP 100
MNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDP
Sbjct: 12 PMNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDP 71
Query: 101 PNIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEG 160
PNIAGLSHFC+HMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEG
Sbjct: 72 PNIAGLSHFCQHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEG 131
Query: 161 ALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGT 220
ALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGT
Sbjct: 132 ALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGT 191
Query: 221 GNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVEN 280
GNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVEN
Sbjct: 192 GNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVEN 251
Query: 281 KNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGH 340
KNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGH
Sbjct: 252 KNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGH 311
Query: 341 EGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQK 400
EGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQK
Sbjct: 312 EGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQK 371
Query: 401 LRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFR 460
LRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFR
Sbjct: 372 LRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFR 431
Query: 461 PDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNG 520
PDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNG
Sbjct: 432 PDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNG 491
Query: 521 KFKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFS 580
KFKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFS
Sbjct: 492 KFKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFS 551
Query: 581 PFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPI 640
PFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPI
Sbjct: 552 PFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPI 611
Query: 641 LLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDEL 700
LLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDEL
Sbjct: 612 LLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDEL 671
Query: 701 KEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLP 760
KEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLP
Sbjct: 672 KEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLP 731
Query: 761 SQLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCF 820
SQLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCF
Sbjct: 732 SQLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCF 791
Query: 821 NTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEE 880
NTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEE
Sbjct: 792 NTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEE 851
Query: 881 AFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFY 940
AFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFY
Sbjct: 852 AFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFY 911
Query: 941 KEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKR 1000
KEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKR
Sbjct: 912 KEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKR 971
Query: 1001 GLPLFPLVKPHINFMAAKL 1019
GLPLFPLVKPHINFMAAKL
Sbjct: 972 GLPLFPLVKPHINFMAAKL 990
>pdb|2JG4|A Chain A, Substrate-Free Ide Structure In Its Closed Conformation
pdb|2JG4|B Chain B, Substrate-Free Ide Structure In Its Closed Conformation
Length = 990
Score = 1217 bits (3150), Expect = 0.0, Method: Composition-based stats.
Identities = 977/979 (99%), Positives = 978/979 (99%)
Query: 41 KMNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDP 100
MNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDP
Sbjct: 12 PMNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDP 71
Query: 101 PNIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEG 160
PNIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEG
Sbjct: 72 PNIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEG 131
Query: 161 ALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGT 220
ALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGT
Sbjct: 132 ALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGT 191
Query: 221 GNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVEN 280
GNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVEN
Sbjct: 192 GNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVEN 251
Query: 281 KNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGH 340
KNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGH
Sbjct: 252 KNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGH 311
Query: 341 EGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQK 400
EGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQK
Sbjct: 312 EGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQK 371
Query: 401 LRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFR 460
LRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFR
Sbjct: 372 LRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFR 431
Query: 461 PDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNG 520
PDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNG
Sbjct: 432 PDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNG 491
Query: 521 KFKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFS 580
KFKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFS
Sbjct: 492 KFKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFS 551
Query: 581 PFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPI 640
PFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPI
Sbjct: 552 PFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPI 611
Query: 641 LLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDEL 700
LLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDEL
Sbjct: 612 LLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDEL 671
Query: 701 KEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLP 760
KEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLP
Sbjct: 672 KEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLP 731
Query: 761 SQLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCF 820
SQLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCF
Sbjct: 732 SQLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCF 791
Query: 821 NTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEE 880
NTLRTKEQLG+IVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEE
Sbjct: 792 NTLRTKEQLGFIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEE 851
Query: 881 AFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFY 940
AFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFY
Sbjct: 852 AFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFY 911
Query: 941 KEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKR 1000
KEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKR
Sbjct: 912 KEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKR 971
Query: 1001 GLPLFPLVKPHINFMAAKL 1019
GLPLFPLVKPHINFMAAKL
Sbjct: 972 GLPLFPLVKPHINFMAAKL 990
>ref|XP_534963.2| PREDICTED: similar to Insulin-degrading enzyme (Insulysin)
(Insulinase) (Insulin protease) [Canis familiaris]
Length = 994
Score = 1215 bits (3145), Expect = 0.0, Method: Composition-based stats.
Identities = 980/1019 (96%), Positives = 986/1019 (96%), Gaps = 25/1019 (2%)
Query: 1 MRYRLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED 60
MRY LAWLLH A PSTFRSVLGARLP PERLCGFQ+K+YSKMNNPAIKR+GNHI KSPED
Sbjct: 1 MRYPLAWLLHSARPSTFRSVLGARLPLPERLCGFQEKSYSKMNNPAIKRLGNHIIKSPED 60
Query: 61 KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK 120
KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK
Sbjct: 61 KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK 120
Query: 121 YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD 180
YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD
Sbjct: 121 YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD 180
Query: 181 REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE 240
REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE
Sbjct: 181 REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE 240
Query: 241 LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ 300
LLKFHS YYSSNLMA+CVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ
Sbjct: 241 LLKFHSTYYSSNLMAICVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ 300
Query: 301 LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV 360
LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV
Sbjct: 301 LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV 360
Query: 361 GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 420
GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV
Sbjct: 361 GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV 420
Query: 421 AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI 480
AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI
Sbjct: 421 AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI 480
Query: 481 VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL 540
VSKSFEGKTDRTEEWYGTQYKQEA+PDEVIK IL L
Sbjct: 481 VSKSFEGKTDRTEEWYGTQYKQEAVPDEVIK-------------------------ILSL 515
Query: 541 EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL 600
EKEA PYP+LIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL
Sbjct: 516 EKEAHPYPSLIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL 575
Query: 601 KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE 660
KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE
Sbjct: 576 KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE 635
Query: 661 IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 720
IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL
Sbjct: 636 IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL 695
Query: 721 SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 780
SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ
Sbjct: 696 SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ 755
Query: 781 QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 840
QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA
Sbjct: 756 QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA 815
Query: 841 NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL 900
NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL
Sbjct: 816 NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL 875
Query: 901 SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA 960
SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA
Sbjct: 876 SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA 935
Query: 961 REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL 1019
REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL
Sbjct: 936 REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL 994
>gb|EDL41785.1| insulin degrading enzyme [Mus musculus]
Length = 978
Score = 1208 bits (3125), Expect = 0.0, Method: Composition-based stats.
Identities = 941/978 (96%), Positives = 963/978 (98%)
Query: 42 MNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPP 101
M+NPAI+RI + I KSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPP
Sbjct: 1 MSNPAIQRIEDQIVKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPP 60
Query: 102 NIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGA 161
NI GLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGA
Sbjct: 61 NIPGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGA 120
Query: 162 LDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTG 221
LDRFAQFFLCPLFD SCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTG
Sbjct: 121 LDRFAQFFLCPLFDASCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTG 180
Query: 222 NKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENK 281
NKYTLETRPNQEGIDVR+ELLKFHS YYSSNLMA+CVLGRESLDDLTNLVVKLFSEVENK
Sbjct: 181 NKYTLETRPNQEGIDVREELLKFHSTYYSSNLMAICVLGRESLDDLTNLVVKLFSEVENK 240
Query: 282 NVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHE 341
NVPLPEFPEHPFQEEHL+QLYKIVPIKDIRNLYVTFPIPDLQ+YYKSNPGHYLGHLIGHE
Sbjct: 241 NVPLPEFPEHPFQEEHLRQLYKIVPIKDIRNLYVTFPIPDLQQYYKSNPGHYLGHLIGHE 300
Query: 342 GPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKL 401
GPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKL
Sbjct: 301 GPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKL 360
Query: 402 RAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRP 461
RAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAG LHYYPL VLTAEYLLEEFRP
Sbjct: 361 RAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGKLHYYPLNGVLTAEYLLEEFRP 420
Query: 462 DLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGK 521
DLI+MVLDKLRPENVRVAIVSKSFEGKTDRTE+WYGTQYKQEAIP+++I+KWQNADLNGK
Sbjct: 421 DLIDMVLDKLRPENVRVAIVSKSFEGKTDRTEQWYGTQYKQEAIPEDIIQKWQNADLNGK 480
Query: 522 FKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSP 581
FKLPTKNEFIPTNFEIL LEK+ATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSP
Sbjct: 481 FKLPTKNEFIPTNFEILSLEKDATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSP 540
Query: 582 FAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPIL 641
FAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPIL
Sbjct: 541 FAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPIL 600
Query: 642 LKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELK 701
LKKI EKMATFEID+KRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELK
Sbjct: 601 LKKITEKMATFEIDKKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELK 660
Query: 702 EALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPS 761
EALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALG+MQMVEDTLIEHAHTKPLLPS
Sbjct: 661 EALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGVMQMVEDTLIEHAHTKPLLPS 720
Query: 762 QLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFN 821
QLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFN
Sbjct: 721 QLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFN 780
Query: 822 TLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEA 881
TLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEK+IEDMTEEA
Sbjct: 781 TLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKAIEDMTEEA 840
Query: 882 FQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYK 941
FQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYN+DRDN EVAYLKTLTK+DII+FY+
Sbjct: 841 FQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNYDRDNIEVAYLKTLTKDDIIRFYQ 900
Query: 942 EMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRG 1001
EMLAVDAPRRHKVSVHVLAREMDSCPVVGEFP QNDINLS+AP LPQPEVI NMTEFKRG
Sbjct: 901 EMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPSQNDINLSEAPPLPQPEVIHNMTEFKRG 960
Query: 1002 LPLFPLVKPHINFMAAKL 1019
LPLFPLVKPHINFMAAKL
Sbjct: 961 LPLFPLVKPHINFMAAKL 978
>pdb|2WBY|A Chain A, Crystal Structure Of Human Insulin-Degrading Enzyme In
Complex With Insulin
pdb|2WBY|B Chain B, Crystal Structure Of Human Insulin-Degrading Enzyme In
Complex With Insulin
pdb|2WC0|A Chain A, Crystal Structure Of Human Insulin Degrading Enzyme In
Complex With Iodinated Insulin
pdb|2WC0|B Chain B, Crystal Structure Of Human Insulin Degrading Enzyme In
Complex With Iodinated Insulin
Length = 990
Score = 1202 bits (3111), Expect = 0.0, Method: Composition-based stats.
Identities = 964/979 (98%), Positives = 965/979 (98%)
Query: 41 KMNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDP 100
MNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDP
Sbjct: 12 PMNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDP 71
Query: 101 PNIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEG 160
PNIAGLSHF +HMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEG
Sbjct: 72 PNIAGLSHFLQHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEG 131
Query: 161 ALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGT 220
ALDRFAQFFL PLFDES KDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGT
Sbjct: 132 ALDRFAQFFLSPLFDESAKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGT 191
Query: 221 GNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVEN 280
GNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAV VLGRESLDDLTNLVVKLFSEVEN
Sbjct: 192 GNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVVVLGRESLDDLTNLVVKLFSEVEN 251
Query: 281 KNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGH 340
KNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGH
Sbjct: 252 KNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGH 311
Query: 341 EGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQK 400
EGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQK
Sbjct: 312 EGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQK 371
Query: 401 LRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFR 460
LRAEGPQEWVFQE KDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFR
Sbjct: 372 LRAEGPQEWVFQELKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFR 431
Query: 461 PDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNG 520
PDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNG
Sbjct: 432 PDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNG 491
Query: 521 KFKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFS 580
KFKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKA LNFEFFS
Sbjct: 492 KFKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKANLNFEFFS 551
Query: 581 PFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPI 640
PFAYVDPLH NMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPI
Sbjct: 552 PFAYVDPLHSNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPI 611
Query: 641 LLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDEL 700
LLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDEL
Sbjct: 612 LLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDEL 671
Query: 701 KEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLP 760
KEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLP
Sbjct: 672 KEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLP 731
Query: 761 SQLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCF 820
SQLVRYREVQLPDRGWFVYQQRNEVHNN GIEIYYQTDMQSTSENMFLELF QIISEP F
Sbjct: 732 SQLVRYREVQLPDRGWFVYQQRNEVHNNSGIEIYYQTDMQSTSENMFLELFAQIISEPAF 791
Query: 821 NTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEE 880
NTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEE
Sbjct: 792 NTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEE 851
Query: 881 AFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFY 940
AFQKHIQALAIRRLDKPKKLSAE AKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFY
Sbjct: 852 AFQKHIQALAIRRLDKPKKLSAESAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFY 911
Query: 941 KEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKR 1000
KEMLAVDAPRRHKVSVHVLAREMDS PVVGEFP QNDINLSQAPALPQPEVIQNMTEFKR
Sbjct: 912 KEMLAVDAPRRHKVSVHVLAREMDSNPVVGEFPAQNDINLSQAPALPQPEVIQNMTEFKR 971
Query: 1001 GLPLFPLVKPHINFMAAKL 1019
GLPLFPLVKPHINFMAAKL
Sbjct: 972 GLPLFPLVKPHINFMAAKL 990
>ref|NP_001082994.1| insulin-degrading enzyme [Danio rerio]
gb|AAI39608.1| Zgc:162603 protein [Danio rerio]
Length = 978
Score = 1195 bits (3093), Expect = 0.0, Method: Composition-based stats.
Identities = 873/978 (89%), Positives = 937/978 (95%)
Query: 42 MNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPP 101
M++PA+KR+ + I +SPEDKREYRGLE NG+K +LISDPTTDKSSAALDVH+GSLSDP
Sbjct: 1 MSDPAVKRVVSDIIRSPEDKREYRGLEFTNGLKAILISDPTTDKSSAALDVHMGSLSDPE 60
Query: 102 NIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGA 161
NI+GL+HFCEHMLFLGT+KYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHL+GA
Sbjct: 61 NISGLAHFCEHMLFLGTEKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLQGA 120
Query: 162 LDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTG 221
LDRFAQFFLCPLFDESCKDREVNAVDSEHEKN+MNDAWRLFQLEKATGNPKHPFSKFGTG
Sbjct: 121 LDRFAQFFLCPLFDESCKDREVNAVDSEHEKNLMNDAWRLFQLEKATGNPKHPFSKFGTG 180
Query: 222 NKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENK 281
NK TLETRP+Q+GID+R+ELLKFHS YYSSNLM +CVLGRE+LD+LT++VVKLF EVENK
Sbjct: 181 NKLTLETRPSQQGIDIREELLKFHSTYYSSNLMGLCVLGRETLDELTSMVVKLFGEVENK 240
Query: 282 NVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHE 341
NVP+PEFP HPFQEEHL+Q YK+VPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHE
Sbjct: 241 NVPVPEFPTHPFQEEHLRQFYKVVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHE 300
Query: 342 GPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKL 401
GPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDII HMFQYIQKL
Sbjct: 301 GPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIIFHMFQYIQKL 360
Query: 402 RAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRP 461
R EGPQEWVFQECKDLN VAFRFKDKERPRGYTSK+AG+LHYYPLEE+L AEYLLEEFRP
Sbjct: 361 RTEGPQEWVFQECKDLNTVAFRFKDKERPRGYTSKVAGLLHYYPLEEILAAEYLLEEFRP 420
Query: 462 DLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGK 521
DLIEMVLDKLRPENVRVA+VSKSFEG+TDRTEEWYGTQYKQEAI DE IKKW NADLNGK
Sbjct: 421 DLIEMVLDKLRPENVRVAVVSKSFEGQTDRTEEWYGTQYKQEAITDEAIKKWDNADLNGK 480
Query: 522 FKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSP 581
FKLP KNEFIPTNFEI PLEK++ P LIKDTAMSK+WFKQDDKFFLPKACLNFEFFSP
Sbjct: 481 FKLPMKNEFIPTNFEIYPLEKDSPSAPTLIKDTAMSKVWFKQDDKFFLPKACLNFEFFSP 540
Query: 582 FAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPIL 641
FAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNT+YGMYLSVKGYNDKQ IL
Sbjct: 541 FAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTVYGMYLSVKGYNDKQHIL 600
Query: 642 LKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELK 701
LKKIIEKMATFEIDEKRF+IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDEL+
Sbjct: 601 LKKIIEKMATFEIDEKRFDIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELR 660
Query: 702 EALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPS 761
+ALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQ+AL +MQM+EDTLIEHAHTKPLLPS
Sbjct: 661 DALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQSALEMMQMLEDTLIEHAHTKPLLPS 720
Query: 762 QLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFN 821
QL+RYREVQ+PD GW+VYQQRNEVHNNCGIEIYYQTDMQ+T ENM LELFCQIISEPCFN
Sbjct: 721 QLIRYREVQVPDGGWYVYQQRNEVHNNCGIEIYYQTDMQNTHENMLLELFCQIISEPCFN 780
Query: 822 TLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEA 881
TLRTKEQLGYIVFSGPRRANG+QGLRFIIQSEK PHYLESRVEAFL TMEKS+E+M +EA
Sbjct: 781 TLRTKEQLGYIVFSGPRRANGVQGLRFIIQSEKAPHYLESRVEAFLKTMEKSVEEMGDEA 840
Query: 882 FQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYK 941
FQKHIQALAIRRLDKPKKL+AECAKYWGEIISQQYNFDRDN EVAYLKTLTKE I++FY+
Sbjct: 841 FQKHIQALAIRRLDKPKKLAAECAKYWGEIISQQYNFDRDNIEVAYLKTLTKEHIMQFYR 900
Query: 942 EMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRG 1001
++LA+DAPRRHKVSVHVL+REMDSCP+VGEFP QND+NL+ AP+LPQP ++Q+MTEFKR
Sbjct: 901 DLLAIDAPRRHKVSVHVLSREMDSCPLVGEFPAQNDVNLAPAPSLPQPSLVQDMTEFKRS 960
Query: 1002 LPLFPLVKPHINFMAAKL 1019
LPLFPL KPHINFMAAKL
Sbjct: 961 LPLFPLTKPHINFMAAKL 978
>dbj|BAF62161.1| insulin-degrading enzyme [Danio rerio]
Length = 998
Score = 1191 bits (3083), Expect = 0.0, Method: Composition-based stats.
Identities = 871/979 (88%), Positives = 936/979 (95%)
Query: 41 KMNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDP 100
+M++PA+KR+ + I +SPEDKREYRGLE NG+K +LISDPTTDKSSAALDVH+GSLSDP
Sbjct: 20 RMSDPAVKRVVSDIIRSPEDKREYRGLESTNGLKAILISDPTTDKSSAALDVHMGSLSDP 79
Query: 101 PNIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEG 160
NI+GL+HFCEHMLFLGT+KYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHL+G
Sbjct: 80 ENISGLAHFCEHMLFLGTEKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLQG 139
Query: 161 ALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGT 220
ALDRFAQFFLCPLFDESCKDREVNAVDSEHEKN+MNDAWRLFQLEKATGNPKHPFSKFGT
Sbjct: 140 ALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNLMNDAWRLFQLEKATGNPKHPFSKFGT 199
Query: 221 GNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVEN 280
GNK TLETRP+Q+GID+R+ELLKFHS YYSSNLM +CVLGRE+LD+LT++VVKLF EVEN
Sbjct: 200 GNKLTLETRPSQQGIDIREELLKFHSTYYSSNLMGLCVLGRETLDELTSMVVKLFGEVEN 259
Query: 281 KNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGH 340
KNVP+PEFP HPFQEEHL+Q YK+VPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGH
Sbjct: 260 KNVPVPEFPTHPFQEEHLRQFYKVVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGH 319
Query: 341 EGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQK 400
EGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDII HMFQYIQK
Sbjct: 320 EGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIIFHMFQYIQK 379
Query: 401 LRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFR 460
LR EGPQEWVFQECKDLN VAFRFKDKERPRGYTSK+AG+LHYYPLEE+L AEYLLEEFR
Sbjct: 380 LRTEGPQEWVFQECKDLNTVAFRFKDKERPRGYTSKVAGLLHYYPLEEILAAEYLLEEFR 439
Query: 461 PDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNG 520
PDLIEMVLDKLRPENVRVA+VSKSFEG+TDRTEEWYGTQYKQEAI DE IKKW NADLNG
Sbjct: 440 PDLIEMVLDKLRPENVRVAVVSKSFEGQTDRTEEWYGTQYKQEAITDEAIKKWDNADLNG 499
Query: 521 KFKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFS 580
KFKLP KNEFIPTNFEI PLEK++ P LIKDTAMSK+WFKQDDKFFLPKACLNFEFFS
Sbjct: 500 KFKLPMKNEFIPTNFEIYPLEKDSPSAPTLIKDTAMSKVWFKQDDKFFLPKACLNFEFFS 559
Query: 581 PFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPI 640
PFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNT+YGMYLSVKGYNDKQ I
Sbjct: 560 PFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTVYGMYLSVKGYNDKQHI 619
Query: 641 LLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDEL 700
LLKKIIEKMATFEIDEKRF+IIKEAYMR LNNFRAEQPHQHAMYYLRLLMTEVAWTKDEL
Sbjct: 620 LLKKIIEKMATFEIDEKRFDIIKEAYMRPLNNFRAEQPHQHAMYYLRLLMTEVAWTKDEL 679
Query: 701 KEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLP 760
++ALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQ+AL +MQM+EDTLIEHAHTKPLLP
Sbjct: 680 RDALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQSALEMMQMLEDTLIEHAHTKPLLP 739
Query: 761 SQLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCF 820
SQL+RYREVQ+PD GW+VYQQRNEVHNNCGIEIYYQTDMQ+T ENM LELFCQIISEPCF
Sbjct: 740 SQLIRYREVQVPDGGWYVYQQRNEVHNNCGIEIYYQTDMQNTHENMLLELFCQIISEPCF 799
Query: 821 NTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEE 880
NTLRTKEQLGYIVFSGPRRANG+QGLRFIIQSEK PHYLESRVEAFL TMEKS+E+M +E
Sbjct: 800 NTLRTKEQLGYIVFSGPRRANGVQGLRFIIQSEKAPHYLESRVEAFLKTMEKSVEEMGDE 859
Query: 881 AFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFY 940
AFQKHIQALAIRRLDKPKKL+AECAKYWGEIISQQYNFDRDN EVAYLKTLTKE I++FY
Sbjct: 860 AFQKHIQALAIRRLDKPKKLAAECAKYWGEIISQQYNFDRDNIEVAYLKTLTKEHIMQFY 919
Query: 941 KEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKR 1000
+++LA+DAPRRHKVSVHVL+REMDSCP+VGEFP QND+NL+ AP+LPQP ++Q+MTEFKR
Sbjct: 920 RDLLAIDAPRRHKVSVHVLSREMDSCPLVGEFPAQNDVNLAPAPSLPQPSLVQDMTEFKR 979
Query: 1001 GLPLFPLVKPHINFMAAKL 1019
LPLFPL KPHINFMAA L
Sbjct: 980 SLPLFPLTKPHINFMAANL 998
>ref|XP_001847597.1| metalloprotease [Culex pipiens quinquefasciatus]
gb|EDS26498.1| metalloprotease [Culex pipiens quinquefasciatus]
Length = 998
Score = 1092 bits (2826), Expect = 0.0, Method: Composition-based stats.
Identities = 484/965 (50%), Positives = 678/965 (70%), Gaps = 1/965 (0%)
Query: 52 NHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCE 111
+ I KS +D R YRGL L+NG+KVLLISDPTTDKS+AAL V +G LSDP I GL+HFCE
Sbjct: 26 DDIVKSQQDNRLYRGLRLSNGLKVLLISDPTTDKSAAALAVEVGHLSDPDEIPGLAHFCE 85
Query: 112 HMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLC 171
HMLFLGTKKY EN+Y FLSE+ GSSNA T + T YYFDV E L+ ALDRF+QFF+
Sbjct: 86 HMLFLGTKKYINENDYMAFLSENGGSSNAATYADTTKYYFDVVPEKLQEALDRFSQFFIA 145
Query: 172 PLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPN 231
PLF ES +RE+NAV SEHEKN+ D WR+ Q+ K+ +PKHP++KFGTG+K TL P
Sbjct: 146 PLFTESATEREINAVHSEHEKNLSMDVWRIRQVNKSLCDPKHPYNKFGTGSKKTLLEDPK 205
Query: 232 QEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEH 291
I++R+EL+KFHS +YS+N+M++ V G+ESLD+L ++VV +FS++ENKNV P + +
Sbjct: 206 LSKINIREELMKFHSKWYSANIMSLAVFGKESLDELESMVVSMFSDIENKNVTSPCWKDL 265
Query: 292 PFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELK 351
PF+EEHL +VP+KD R+L +TF DL++YYK+ P HY+ HLIGHEG GS+LSELK
Sbjct: 266 PFKEEHLATKTTVVPVKDTRSLTITFQTEDLERYYKAGPEHYVSHLIGHEGAGSILSELK 325
Query: 352 SKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVF 411
+KGW N LVGG RGF FF + VDLT++G HV+DI+ +FQYI L+ EGPQ+W+F
Sbjct: 326 AKGWCNNLVGGYSTIGRGFGFFEVMVDLTQDGFDHVDDIVKIIFQYIHMLKTEGPQKWIF 385
Query: 412 QECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKL 471
+E DL + FRFKDKE P S + + YPLEEVL A YL+ E+RP+LIE + +K
Sbjct: 386 EEYCDLCEMQFRFKDKENPLSLVSNVVHSMQSYPLEEVLAAPYLISEWRPELIEELWNKF 445
Query: 472 RPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFI 531
P+N R+ +V + E T++ EEWYGT+Y EAIP V+++W DLN LP +N FI
Sbjct: 446 FPQNARITVVGQKCESVTNQEEEWYGTKYSSEAIPKNVLEEWAKPDLNANLHLPERNPFI 505
Query: 532 PTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCN 591
PT+FE++P++ + P +I +T M ++WFKQD +F PK +N +F SP Y DPL+CN
Sbjct: 506 PTDFELVPVDADIQSTPVIIHNTPMIRVWFKQDVEFLKPKTLMNLDFCSPIVYSDPLNCN 565
Query: 592 MAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMAT 651
+ +L+++L KD LNEY YAA+LAGL + NT YG+ +S+ GY+ KQ ILL+K+++ +
Sbjct: 566 LTHLFVQLFKDHLNEYLYAADLAGLRLVVSNTTYGISVSIGGYSHKQHILLEKVLDNLYN 625
Query: 652 FEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPR 711
F+IDEKRF+I+KE Y+R+L N+ AEQP+QHA+YYL LL+TE AW+K EL +A D +++ R
Sbjct: 626 FKIDEKRFDILKEQYVRNLKNYNAEQPYQHAVYYLALLLTEQAWSKQELIDAADLLSVDR 685
Query: 712 LKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIE-HAHTKPLLPSQLVRYREVQ 770
L++FI +LLSR+H+E ++GN+ K+ AL I VED L A PLL QL+ RE +
Sbjct: 686 LRSFIDELLSRMHVECFIYGNVNKENALEISGKVEDKLKNTDASVVPLLARQLMLKREYK 745
Query: 771 LPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLG 830
L + +++ N+ H + E+Y Q MQ N+F++L QI+SEPC+N LRTKEQLG
Sbjct: 746 LNNGENCLFETNNDYHKSSCAELYLQCGMQDDQSNVFVDLVTQILSEPCYNQLRTKEQLG 805
Query: 831 YIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALA 890
YIVF G R++NG+QG+R I+QS K P Y+E R+E FL M + +E+M+EE F++H +ALA
Sbjct: 806 YIVFCGSRKSNGVQGIRVIVQSAKHPAYVEERIEHFLNGMIEQLENMSEEEFKRHKEALA 865
Query: 891 IRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPR 950
++L+KPK+LS + K+ EI QQY+F+R EVA+L+TLTK+ II++YK+ + + AP
Sbjct: 866 AQKLEKPKRLSTQFGKFLTEISLQQYHFNRAQVEVAFLQTLTKQQIIEYYKDYIILGAPS 925
Query: 951 RHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKP 1010
R +S+HV++ P + + ++ + ++ FK L+P+V+P
Sbjct: 926 RRSLSIHVVSTAEGGAGHRDAPPEATERSTNETADAKDFVKVCDLASFKSTRALYPMVQP 985
Query: 1011 HINFM 1015
+I+
Sbjct: 986 YIDIK 990
>ref|XP_001661876.1| metalloprotease [Aedes aegypti]
gb|EAT36161.1| metalloprotease [Aedes aegypti]
Length = 1003
Score = 1090 bits (2819), Expect = 0.0, Method: Composition-based stats.
Identities = 483/965 (50%), Positives = 670/965 (69%), Gaps = 1/965 (0%)
Query: 52 NHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCE 111
++ITKS +D R YRGL+L NG+KVLLISDPTTDKS+AAL V +G LSDP I GL+HFCE
Sbjct: 31 DNITKSQQDSRNYRGLQLENGLKVLLISDPTTDKSAAALSVAVGHLSDPDEIPGLAHFCE 90
Query: 112 HMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLC 171
HMLFLGTKKY EN+Y FLSE+ GSSNA T + T YYFDV E L ALDRF+QFF+
Sbjct: 91 HMLFLGTKKYVNENDYMSFLSENGGSSNAATYADTTKYYFDVVPEKLPEALDRFSQFFIA 150
Query: 172 PLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPN 231
PLF ES +RE+NAV SEHEKN+ D WR+ Q+ K+ +PKHP++KFGTG+K TL P
Sbjct: 151 PLFTESATEREINAVHSEHEKNLSMDVWRIRQVNKSLCDPKHPYNKFGTGSKKTLLEDPK 210
Query: 232 QEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEH 291
I++R+EL+KFH+ +YS+N+M++ V G+ESLDDL ++VV +FSE+ENKNV PE+ +
Sbjct: 211 TTNINIREELMKFHAKWYSANIMSLAVFGKESLDDLESMVVGMFSEIENKNVTSPEWKDL 270
Query: 292 PFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELK 351
P++ + L K+VP+KD R+L +TF DL+++Y++ P HY HLIGHEG GS+LSELK
Sbjct: 271 PYKNDQLATKTKVVPVKDSRSLTITFQTEDLEQHYRAGPEHYASHLIGHEGAGSILSELK 330
Query: 352 SKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVF 411
+KGW N LVGG RGF FF + VDLT++G HV+DI+ +FQYI L+ EGPQ+W+F
Sbjct: 331 AKGWCNNLVGGYNTIGRGFGFFEVMVDLTQDGFEHVDDIVKIIFQYINMLKKEGPQKWIF 390
Query: 412 QECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKL 471
+E DL + FRFKDKE P S + + YPLEEVL A YL+ E+RPDLIE + +K
Sbjct: 391 EEYCDLCEMQFRFKDKENPLTLVSSVVHSMQSYPLEEVLAAPYLISEWRPDLIEDLWNKF 450
Query: 472 RPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFI 531
P+N R+ +V + E K EEWYGT+Y E I +V++ W +DLNG LP +N FI
Sbjct: 451 YPQNARITVVGQKCEAKATCEEEWYGTKYSTEKIDAKVLEDWAKSDLNGNLHLPERNPFI 510
Query: 532 PTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCN 591
PTNF++L ++ + P +I +T M ++WFKQD +F PK +N +F SP Y DPL+CN
Sbjct: 511 PTNFDLLAVDADIESIPVIIHNTPMMRVWFKQDVEFLKPKTLMNLDFCSPIVYSDPLNCN 570
Query: 592 MAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMAT 651
+ +L+++L KD LNEY YAA LAGL + NT YG+ +S+ GY+ KQ ILL+K+++ M
Sbjct: 571 LTHLFVQLFKDHLNEYLYAAGLAGLRLGVANTTYGVSVSIGGYSHKQHILLEKVLDDMFN 630
Query: 652 FEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPR 711
F+IDEKRFEI+KE Y+R+L N++AEQP+QHA+YYL LL+TE AW+K EL +A + VT+ R
Sbjct: 631 FKIDEKRFEILKEQYIRNLKNYQAEQPYQHAVYYLALLLTEQAWSKQELIDATELVTVDR 690
Query: 712 LKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIE-HAHTKPLLPSQLVRYREVQ 770
L+ FI +LLSR+H+E ++GN+ K+ AL + VED L + A+ PLL QL+ RE +
Sbjct: 691 LRTFIDELLSRMHVECFIYGNVNKEKALEMSSKVEDKLKKTDANVVPLLARQLMLKREYK 750
Query: 771 LPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLG 830
L + +++ NE H + E+Y Q MQ+ N++++L QI+SEPC+N LRTKEQLG
Sbjct: 751 LNNGENCLFEMTNEFHKSSCAELYLQCGMQNDQANVYVDLVTQILSEPCYNQLRTKEQLG 810
Query: 831 YIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALA 890
YIVF G R++NG+QG+R I+QS P ++E R+E FL M +E+MTEE F++H +ALA
Sbjct: 811 YIVFCGSRKSNGVQGIRVIVQSANHPAFVEERIEHFLNGMVDYLENMTEEEFKRHKEALA 870
Query: 891 IRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPR 950
+L+KPK+LS++ K+ EI QQY+F+R EVA+L+TLTK+ I+ +YKE + DA
Sbjct: 871 AMKLEKPKRLSSQFTKFLNEIALQQYHFNRAQVEVAFLQTLTKQQIVDYYKEYIVKDASL 930
Query: 951 RHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKP 1010
R +S+HV++ + A + ++ FK L+P+V+P
Sbjct: 931 RRSLSIHVVSTAEGGAGHKDASADVAKQSTDDASTQKDFVKVGDLAGFKSTRALYPMVQP 990
Query: 1011 HINFM 1015
+I+
Sbjct: 991 YIDIK 995
>ref|XP_971897.1| PREDICTED: similar to Insulin-degrading enzyme (Insulysin)
(Insulinase) (Insulin protease) [Tribolium castaneum]
Length = 977
Score = 1084 bits (2803), Expect = 0.0, Method: Composition-based stats.
Identities = 521/974 (53%), Positives = 716/974 (73%), Gaps = 7/974 (0%)
Query: 41 KMNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDP 100
+ + R +I KS EDKR YRGLELAN +KVLL+SDPTTDKS+AA+DV++G +SDP
Sbjct: 2 ENTPNLVLRRVENIIKSQEDKRLYRGLELANHMKVLLVSDPTTDKSAAAMDVNVGFMSDP 61
Query: 101 PNIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEG 160
++ GL+HFCEHMLFLGTKKYP EN+Y+++LSEH GSSNA T +HT YYFD+ + L
Sbjct: 62 RDVYGLAHFCEHMLFLGTKKYPNENDYNKYLSEHGGSSNAATYPDHTIYYFDIVPDELNN 121
Query: 161 ALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGT 220
ALDRF+QFF+ PLF ES DRE+NAV+SEHEKN+ ND WR QL+K +PKHP+ FGT
Sbjct: 122 ALDRFSQFFIAPLFTESATDREMNAVNSEHEKNIPNDVWRKDQLDKHLADPKHPYHTFGT 181
Query: 221 GNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVEN 280
GN++TL+T P ++ I+VR ELLKFH +YSSN+M + VLG+ESLDDL +VVKLFSEV++
Sbjct: 182 GNRHTLDTLPKEKNINVRDELLKFHDKWYSSNIMCLAVLGKESLDDLEQMVVKLFSEVKD 241
Query: 281 KNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGH 340
K + P + EHPF++EH + PIKD+RNL + FP DLQ+YYKS+P HY+ HL+GH
Sbjct: 242 KAIAAPRWEEHPFKDEHFGTCVYMYPIKDVRNLNIVFPCRDLQEYYKSSPSHYISHLMGH 301
Query: 341 EGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQK 400
EGPGS+LS LK++GW N LV G + RG FF + VDLTEEG+ H++DI+ +FQY+
Sbjct: 302 EGPGSILSTLKARGWSNNLVAGSRPAPRGLGFFGVTVDLTEEGIKHIDDIVELIFQYLNM 361
Query: 401 LRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFR 460
L+ +GPQ+WV E +D+ + FRFKDKE PR Y + + L Y +E+VL+ YL E+R
Sbjct: 362 LKRQGPQKWVQDENRDIGNMLFRFKDKESPRSYIAGLVHTLQDYSMEDVLSCMYLFSEWR 421
Query: 461 PDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNG 520
PD+IE V + PE +R+ +++K +E + D+ E WYGT+YK IP++ +++W+ ++L+G
Sbjct: 422 PDIIEQVWNDFVPEKIRIVVLAKQYENELDQVEPWYGTKYKVAKIPEKTLERWRKSELSG 481
Query: 521 KFKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFS 580
FKLP KNEFIPT+FE+ P++KE T +P +I+DTA++++WFKQD+ F LPKA + F+F S
Sbjct: 482 DFKLPEKNEFIPTDFELYPIDKEVTEHPVIIQDTALTRVWFKQDETFLLPKANVMFDFVS 541
Query: 581 PFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPI 640
P AY+DPL+CN+ ++ ++L +D+LNEYAYAAELAGL ++L NT YG+ L++ GY++KQ I
Sbjct: 542 PLAYLDPLNCNLTHMLVQLFRDALNEYAYAAELAGLKWELINTKYGLILAIGGYSNKQHI 601
Query: 641 LLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDEL 700
L K++EK+ F+ID KRFEI KE Y+R+L NF AEQP+QHA+YYL L+TE +WTK EL
Sbjct: 602 FLDKVMEKLTNFKIDPKRFEICKENYIRNLKNFAAEQPYQHAVYYLAALLTEHSWTKQEL 661
Query: 701 KEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLP 760
+ +T+ +L+AFIPQ+LS++HIE L+HGN K+ AL ++Q+VED L+ + PLLP
Sbjct: 662 LATTEQLTIDKLEAFIPQILSKMHIECLIHGNANKEKALQLVQIVEDRLLSTLNMSPLLP 721
Query: 761 SQLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCF 820
QL+ RE++L D +VY+ +NEVH IE+YYQ +QS NM LELF QI+ EPCF
Sbjct: 722 RQLLLNRELKLEDGCNYVYEVQNEVHKESCIELYYQCGLQSKENNMKLELFAQIVQEPCF 781
Query: 821 NTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEE 880
+ LRTKEQLGYIVFSG RR+NG+QGLR I+QS+K P L+ R+E FL M +++M+EE
Sbjct: 782 DILRTKEQLGYIVFSGIRRSNGVQGLRIIVQSDKHPVRLDERIEEFLKNMLSYLKNMSEE 841
Query: 881 AFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFY 940
F +H +ALA +RL+KPK+LS + +WGEI SQQY+FDR N EVAYL+TLTKEDII FY
Sbjct: 842 EFARHREALAAQRLEKPKQLSTQTNIFWGEITSQQYHFDRANVEVAYLRTLTKEDIIDFY 901
Query: 941 KEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKR 1000
K +L +A R K+SVHV++ + + ++ + V+ ++T FK
Sbjct: 902 KSLLEENAQFRKKLSVHVVSMADGGAGKMAASDKEYTVD-------SKGTVVCDITVFKS 954
Query: 1001 GLPLFPLVKPHINF 1014
+ PLV+P+IN
Sbjct: 955 SHEMHPLVQPYINI 968
>ref|XP_001603463.1| PREDICTED: similar to metalloprotease [Nasonia vitripennis]
Length = 999
Score = 1080 bits (2794), Expect = 0.0, Method: Composition-based stats.
Identities = 524/987 (53%), Positives = 712/987 (72%), Gaps = 6/987 (0%)
Query: 31 LCGFQKKTYSKMNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAAL 90
L KK+ +K + R N+I KSP DKR+YRGL L N +KVLLISDP TDKS+A+L
Sbjct: 3 LSKSFKKSITKHQSKEPTRY-NNIVKSPNDKRDYRGLILHNKLKVLLISDPMTDKSAASL 61
Query: 91 DVHIGSLSDPPNIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYY 150
DV++G LSDP + GL+HFCEHMLFLGT KYP+ N+Y+Q+LS++ G+SNA T +HTNYY
Sbjct: 62 DVNVGYLSDPKELPGLAHFCEHMLFLGTTKYPEVNDYNQYLSQNGGASNAATYLDHTNYY 121
Query: 151 FDVSHEHLEGALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGN 210
FDV+ + LEGALDRF+QFF+ PLF ES ++E+ AV EHEKN+ ND WR+ QL+K++ +
Sbjct: 122 FDVNPDKLEGALDRFSQFFVSPLFTESATEKEITAVHLEHEKNIANDTWRMDQLDKSSAD 181
Query: 211 PKHPFSKFGTGNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNL 270
P H +SKFGTG+K TLE P Q+ IDVRQELL FH+ +YS+N+MA+ VLG+ESLDDL +
Sbjct: 182 PSHAYSKFGTGSKDTLEVIPKQKNIDVRQELLNFHNTWYSANIMALSVLGKESLDDLEKM 241
Query: 271 VVKLFSEVENKNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNP 330
+V +FS+++NKNV +P++P HPF +EH K + IVPIKDIRNL +TFPIPD+Q+++++ P
Sbjct: 242 IVDMFSDIDNKNVEVPKWPAHPFTDEHFKTKWFIVPIKDIRNLNITFPIPDMQEHFRAAP 301
Query: 331 GHYLGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDI 390
HY HL+GHEG GSLLS LK KGW N+LV G++ ARGF FF + VDLTEEG+LHV+DI
Sbjct: 302 VHYWSHLLGHEGKGSLLSTLKEKGWCNSLVSGKRSSARGFDFFSVYVDLTEEGILHVDDI 361
Query: 391 ILHMFQYIQKLRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVL 450
+ FQYI L+ EGP EW+F+E D+ + FRFK+K PR Y + L YP+EEVL
Sbjct: 362 VTMTFQYINMLKNEGPVEWIFEEYSDIAKMNFRFKEKASPRSYVNVTVQSLQDYPIEEVL 421
Query: 451 TAEYLLEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVI 510
+A L ++RPDLI + + L PE +RV +V+K++E D E WYGT+YK+E IP+++I
Sbjct: 422 SASRLFTQWRPDLINELNNYLVPEKIRVQVVAKAYEANADSVEPWYGTKYKKEKIPEDLI 481
Query: 511 KKWQNADLNGKFKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLP 570
++W NA + F+LP KNEFIPT F+I +EK +P +I+D + WFKQDD+F LP
Sbjct: 482 QRWNNAGTDEAFQLPEKNEFIPTKFDIKSIEKAE-KFPTIIEDNPFIRTWFKQDDEFLLP 540
Query: 571 KACLNFEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLS 630
KA + F+F SP Y+DP+ NM Y++++L +DSLNEYAY+A+LAGL ++L ++ YG+ L
Sbjct: 541 KATMTFDFVSPLTYIDPISSNMTYMFVQLFRDSLNEYAYSADLAGLKWELSHSKYGLSLI 600
Query: 631 VKGYNDKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLM 690
+ GY+ K +LL KI+++M F ID+KRF I+KE Y+R L NF AEQP+QHA YYL LM
Sbjct: 601 IAGYDHKLVVLLNKILDRMVNFTIDDKRFAILKENYIRGLKNFEAEQPYQHAAYYLAALM 660
Query: 691 TEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLI 750
+E W K+EL A +T R++ FIP L+S++HIE L+HGNITK AL ++ VE LI
Sbjct: 661 SEQVWVKNELLNACSMLTADRVRQFIPLLMSKMHIECLIHGNITKAEALKTVKNVESKLI 720
Query: 751 EHAHT-KPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLE 809
PLLP QLV YRE++LP+ ++Y+ N+ H + +IYYQ+ MQST NM LE
Sbjct: 721 SSVKDLTPLLPKQLVLYRELELPNGCHYLYEVDNKHHKSSCTQIYYQSGMQSTESNMLLE 780
Query: 810 LFCQIISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLIT 869
LF QIISEPCFN LRTKEQLGYIVFSG RR NG+QGLR I+QS K P ++E R++AF+ +
Sbjct: 781 LFTQIISEPCFNILRTKEQLGYIVFSGIRRTNGVQGLRIIVQSNKHPQFVEERIDAFMES 840
Query: 870 MEKSIEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLK 929
M+ I +M++E F +H ++LA +RL+KPK L+++ YW EI QQYNFDR N EVAYLK
Sbjct: 841 MKDYITNMSDEEFNRHKESLATQRLEKPKMLTSQSGIYWNEISMQQYNFDRANVEVAYLK 900
Query: 930 TLTKEDIIKFYKEMLAVDAPRRHKVSVHVLAREMDS---CPVVGEFPCQNDINLSQAPAL 986
T+++ II FYK+++ ++P+RHK+S+HV++ V P + + A
Sbjct: 901 TISRSQIIDFYKDVVHSESPQRHKLSIHVVSTAEGGAAAEDVTSSTPSAEETKKTLEQAE 960
Query: 987 PQPEVIQNMTEFKRGLPLFPLVKPHIN 1013
QP IQ++ +FK PL+PLVKP N
Sbjct: 961 QQPARIQDILQFKTSHPLYPLVKPFNN 987
>ref|NP_524182.2| Insulin degrading metalloproteinase CG5517-PA [Drosophila
melanogaster]
gb|AAF51584.2| CG5517-PA [Drosophila melanogaster]
Length = 1031
Score = 1072 bits (2772), Expect = 0.0, Method: Composition-based stats.
Identities = 459/1014 (45%), Positives = 664/1014 (65%), Gaps = 8/1014 (0%)
Query: 4 RLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPEDKRE 63
R + L ++ T R++ P QK K ++ N+I KS +D R+
Sbjct: 18 RRSSALRASISVTHRTIGTLIKPKMTIAESSQKSATRKPDSMEPILRLNNIEKSLQDTRD 77
Query: 64 YRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKKYPK 123
YRGL+L NG+KVLLISDP TD S+AAL V +G +SDP N+ GL+HFCEHMLFLGT+KYP
Sbjct: 78 YRGLQLENGLKVLLISDPNTDVSAAALSVQVGHMSDPTNLPGLAHFCEHMLFLGTEKYPH 137
Query: 124 ENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKDREV 183
EN Y+ +LS+ GSSNA T T Y+F V+ + L+GALDRFAQFF+ PLF S +RE+
Sbjct: 138 ENGYTTYLSQSGGSSNAATYPLMTKYHFHVAPDKLDGALDRFAQFFIAPLFTPSATEREI 197
Query: 184 NAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQELLK 243
NAV+SEHEKN+ +D WR+ Q+ + P H +SKFG+GNK TL P + IDVR ELLK
Sbjct: 198 NAVNSEHEKNLPSDLWRIKQVNRHLAKPDHAYSKFGSGNKTTLSEIPKSKNIDVRDELLK 257
Query: 244 FHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQLYK 303
FH +YS+N+M + V+G+ESLD+L +V++ FSE+ENKNV +P +P HP+ EE Q K
Sbjct: 258 FHKQWYSANIMCLAVIGKESLDELEGMVLEKFSEIENKNVKVPGWPRHPYAEERYGQKVK 317
Query: 304 IVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLVGGQ 363
IVPIKDIR+L ++F DL ++YKS P +YL HLIGHEG GS+LSEL+ GW N L+ G
Sbjct: 318 IVPIKDIRSLTISFTTDDLTQFYKSGPDNYLTHLIGHEGKGSILSELRRLGWCNDLMAGH 377
Query: 364 KEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAVAFR 423
+ GF FF I VDLT+EGL HV+DI+ +FQY++ LR EGP++W+F EC LN + FR
Sbjct: 378 QNTQNGFGFFDIVVDLTQEGLEHVDDIVKIVFQYLEMLRKEGPKKWIFDECVKLNEMRFR 437
Query: 424 FKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAIVSK 483
FK+KE+P + + +PLEEVL A YL E+RPDLI+ +LD+L P R+ IVS+
Sbjct: 438 FKEKEQPENLVTHAVSSMQIFPLEEVLIAPYLSNEWRPDLIKGLLDELVPSKSRIVIVSQ 497
Query: 484 SFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPLEKE 543
SFE D E +Y T+Y + + ++ W+N +LN KL N FIPTNF+I + +
Sbjct: 498 SFEPDCDLAEPYYKTKYGITRVAKDTVQSWENCELNENLKLALPNSFIPTNFDISDVPAD 557
Query: 544 ATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELLKDS 603
A +P +I DT + ++W KQD++F PKAC+ F+ +P AY+DPL+CN+ ++ + LLKD
Sbjct: 558 APKHPTIILDTPILRVWHKQDNQFNKPKACMTFDMSNPIAYLDPLNCNLNHMMVMLLKDQ 617
Query: 604 LNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFEIIK 663
LNEY Y AELA L + G+ +++G++DKQ +LL+K+++ + F IDEKRF+I+K
Sbjct: 618 LNEYLYDAELASLKLSVMGKSCGIDFTIRGFSDKQVVLLEKLLDHLFDFSIDEKRFDILK 677
Query: 664 EAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRL 723
E Y+RSL NF+AEQP+QH++YYL LL+TE AW EL +A++ VT R+ F + RL
Sbjct: 678 EEYVRSLKNFKAEQPYQHSIYYLALLLTENAWANMELLDAMELVTYDRVLNFAKEFFQRL 737
Query: 724 HIEALLHGNITKQAALGIMQMVEDTL-IEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQR 782
H E + GN+TKQ A I V L +A P+L Q+++ RE +L +++++
Sbjct: 738 HTECFIFGNVTKQQATDIAGRVNTRLEATNASKLPILARQMLKKREYKLLAGDSYLFEKE 797
Query: 783 NEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRANG 842
NE H + ++Y Q Q+ N+ + L Q++SEPC++ LRTKEQLGYIVFSG R+ NG
Sbjct: 798 NEFHKSSCAQLYLQCGAQTDHTNIMVNLVSQVLSEPCYDCLRTKEQLGYIVFSGVRKVNG 857
Query: 843 IQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKLSA 902
G+R I+QS K P Y+E R+E FL T + IEDM + F++H +ALA+++L+KPK +
Sbjct: 858 ANGIRIIVQSAKHPSYVEDRIENFLQTYLQVIEDMPLDEFERHKEALAVKKLEKPKTIFQ 917
Query: 903 ECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLARE 962
+ ++++GEI Q Y+F+R+ EVA L+ ++K D + ++K+ +A D R +SVH+++++
Sbjct: 918 QFSQFYGEIAMQTYHFEREEAEVAILRKISKADFVDYFKKFIAKDGEERRVLSVHIVSQQ 977
Query: 963 MDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMA 1016
D P + + + + I ++ FK L+P+ P ++ A
Sbjct: 978 TDENATSEAEPVE-------ITNMERHKPISDIVTFKSCKELYPIALPFLDIKA 1024
>gb|AAO74689.1| RE17458p [Drosophila melanogaster]
Length = 1031
Score = 1071 bits (2771), Expect = 0.0, Method: Composition-based stats.
Identities = 459/1014 (45%), Positives = 665/1014 (65%), Gaps = 8/1014 (0%)
Query: 4 RLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPEDKRE 63
R + L ++ T R++ P QK K ++ N+I KS +D R+
Sbjct: 18 RRSSALRASISVTHRTIGTLIKPKMTIAESSQKSATRKPDSMEPILRLNNIEKSLQDTRD 77
Query: 64 YRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKKYPK 123
YRGL+L NG+KVLLISDP TD S+AAL V +G +SDP N+ GL+HFCEHMLFLGT+KYP
Sbjct: 78 YRGLQLENGLKVLLISDPNTDVSAAALSVQVGHMSDPTNLPGLAHFCEHMLFLGTEKYPH 137
Query: 124 ENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKDREV 183
EN Y+ +LS+ GSSNA T T Y+F V+ + L+GALDRFAQFF+ PLF S +RE+
Sbjct: 138 ENGYTTYLSQSGGSSNAATYPLMTKYHFHVAPDKLDGALDRFAQFFIAPLFTPSATEREI 197
Query: 184 NAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQELLK 243
NAV+SEHEKN+ +D WR+ Q+++ P H +SKFG+GNK TL P + IDVR ELLK
Sbjct: 198 NAVNSEHEKNLPSDLWRIKQVDRHLAKPDHAYSKFGSGNKTTLSEIPKSKNIDVRDELLK 257
Query: 244 FHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQLYK 303
FH +YS+N+M + V+G+ESLD+L +V++ FSE+ENKNV +P +P HP+ EE Q K
Sbjct: 258 FHKQWYSANIMCLAVIGKESLDELEGMVLEKFSEIENKNVKVPGWPRHPYAEERYGQKVK 317
Query: 304 IVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLVGGQ 363
IVPIKDIR+L ++F DL ++YKS P +YL HLIGHEG GS+LSEL+ GW N L+ G
Sbjct: 318 IVPIKDIRSLTISFTTDDLTQFYKSGPDNYLTHLIGHEGKGSILSELRRLGWCNDLMAGH 377
Query: 364 KEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAVAFR 423
+ GF FF I VDLT+EGL HV+DI+ +FQY++ LR EGP++W+F EC LN + FR
Sbjct: 378 QNTQNGFGFFDIVVDLTQEGLEHVDDIVKIVFQYLEMLRKEGPKKWIFDECVKLNEMRFR 437
Query: 424 FKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAIVSK 483
FK+KE+P + + +PLEEVL A YL E+RPDLI+ +LD+L P R+ IVS+
Sbjct: 438 FKEKEQPENLVTHAVSSMQIFPLEEVLIAPYLSNEWRPDLIKGLLDELVPSKSRIVIVSQ 497
Query: 484 SFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPLEKE 543
SFE D E +Y T+Y + + ++ W+N +LN KL N FIPTNF+I + +
Sbjct: 498 SFEPDCDLAEPYYKTKYGITRVAKDTVQSWENCELNENLKLALPNSFIPTNFDISDVPAD 557
Query: 544 ATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELLKDS 603
A +P +I DT + ++W KQD++F PKAC+ F+ +P AY+DPL+CN+ ++ + LLKD
Sbjct: 558 APKHPTIILDTPILRVWHKQDNQFNKPKACMTFDMSNPIAYLDPLNCNLNHMMVMLLKDQ 617
Query: 604 LNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFEIIK 663
LNEY Y AELA L + G+ +++G++DKQ +LL+K+++ + F IDEKRF+I+K
Sbjct: 618 LNEYLYDAELASLKLSVMGKSCGIDFTIRGFSDKQVVLLEKLLDHLFDFSIDEKRFDILK 677
Query: 664 EAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRL 723
E Y+RSL NF+AEQP+QH++YYL LL+TE AW EL +A++ VT R+ F + RL
Sbjct: 678 EEYVRSLKNFKAEQPYQHSIYYLALLLTENAWANMELLDAMELVTYDRVLNFAKEFFQRL 737
Query: 724 HIEALLHGNITKQAALGIMQMVEDTL-IEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQR 782
H E + GN+TKQ A I V L +A P+L Q+++ RE +L +++++
Sbjct: 738 HTECFIFGNVTKQQATDIAGRVNTRLEATNASKLPILARQMLKKREYKLLAGDSYLFEKE 797
Query: 783 NEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRANG 842
NE H + ++Y Q Q+ N+ + L Q++SEPC++ LRTKEQLGYIVFSG R+ NG
Sbjct: 798 NEFHKSSCAQLYLQCGAQTDHTNIMVNLVSQVLSEPCYDCLRTKEQLGYIVFSGVRKVNG 857
Query: 843 IQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKLSA 902
G+R I+QS K P Y+E R+E FL T + IEDM + F++H +ALA+++L+KPK +
Sbjct: 858 ANGIRIIVQSAKHPSYVEDRIENFLQTYLQVIEDMPLDEFERHKEALAVKKLEKPKTIFQ 917
Query: 903 ECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLARE 962
+ ++++GEI Q Y+F+R+ EVA L+ ++K D + ++K+ +A D R +SVH+++++
Sbjct: 918 QFSQFYGEIAMQTYHFEREEAEVAILRKISKADFVDYFKKFIAKDGEERRVLSVHIVSQQ 977
Query: 963 MDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMA 1016
D P + + + + I ++ FK L+P+ P ++ A
Sbjct: 978 TDENATSEAEPVE-------ITNMERHKPISDIVTFKSCKELYPIALPFLDIKA 1024
>emb|CAO23586.1| unnamed protein product [Vitis vinifera]
Length = 965
Score = 1057 bits (2733), Expect = 0.0, Method: Composition-based stats.
Identities = 382/966 (39%), Positives = 551/966 (57%), Gaps = 16/966 (1%)
Query: 49 RIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSH 108
I K D REYR + L N ++VLLISDP TDK++A++ V +GS DP GL+H
Sbjct: 3 EAAAEIVKPRTDTREYRRIVLRNSLEVLLISDPDTDKAAASMSVSVGSFCDPEGFPGLAH 62
Query: 109 FCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQF 168
F EHMLF ++KYP E+ YS+++ EH GS+NAFTS EHTNYYFDV+ + E ALDRFAQF
Sbjct: 63 FLEHMLFYASEKYPLEDSYSKYIIEHGGSTNAFTSSEHTNYYFDVNSDCFEEALDRFAQF 122
Query: 169 FLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLET 228
F+ PL RE+ AVDSE++KN+++DAWR+ QL+K HP+ KF TGN TLE
Sbjct: 123 FVKPLMSADATTREIKAVDSENQKNLLSDAWRMCQLQKHISAEGHPYHKFSTGNWDTLEV 182
Query: 229 RPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEF 288
+P ++G+D R EL+KF+ +YS+NLM + V +ESLD + +LV F E++NK+ +
Sbjct: 183 KPKEKGLDTRHELIKFYEEHYSANLMHLVVYTKESLDKIQSLVEHKFQEIQNKDRSNFQI 242
Query: 289 PEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLS 348
P P EHL+ L K VPIK L V +PI YK P YLGHLIGHEG GSL
Sbjct: 243 PGQPCTSEHLQILVKTVPIKQGHKLRVIWPITPSIHNYKEGPCRYLGHLIGHEGEGSLFY 302
Query: 349 ELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQE 408
LK+ GW +L G+ + F FF + +DLTE G H++DI+ +F+YI L+ G +
Sbjct: 303 ILKTLGWATSLSAGEGDWTCEFSFFKVVIDLTEAGHEHMQDIVGLLFKYISLLQQTGVCK 362
Query: 409 WVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVL 468
W+F E + F ++DK P Y ++ + YP ++ L L +F PD+I+ VL
Sbjct: 363 WIFDELSAICETVFHYQDKIPPIDYVVNVSSNMELYPPKDWLVGSSLPSKFSPDVIQKVL 422
Query: 469 DKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKN 528
D+L P NVR+ SK+FEG TD E WYGT Y E I +I++W A N LP+ N
Sbjct: 423 DELAPNNVRIFWESKNFEGHTDMVEPWYGTAYSIEKITSSMIQQWMLAAPNEHLHLPSPN 482
Query: 529 EFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPL 588
FIPT+ + ++ E +P L++ ++ S LW+K D F PKA + +F PFA P
Sbjct: 483 VFIPTDLSLKDVQ-EKAKFPVLLRKSSYSTLWYKPDTMFSTPKAYVKIDFNCPFASSSPE 541
Query: 589 HCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEK 648
+ ++ LL D LNEYAY A++AGL Y + +T G ++V GYN K ILL+ ++EK
Sbjct: 542 ADVLTDIFTRLLMDYLNEYAYYAQVAGLYYGINHTDSGFQVAVTGYNHKLRILLETVVEK 601
Query: 649 MATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVT 708
+A F++ RF +IKE + NF+ +QP+Q AMYY L++ + W + E + +
Sbjct: 602 IANFKVKPDRFLVIKEMVTKEYQNFKFQQPYQQAMYYCSLILQDNTWPWMDGLEVIPHLE 661
Query: 709 LPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTL--IEHAHTKPLLPSQLVRY 766
L F+P LLSR ++ + GNI + A ++ +ED H ++PL PSQ +
Sbjct: 662 ADDLAKFVPMLLSRAFLDCYIAGNIEPKEAESMIHHIEDIFYSGPHPISQPLFPSQYLTN 721
Query: 767 REVQLPDRGWFVY--QQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLR 824
R ++L + Y + N N + Y Q N+ L+LF I + F+ LR
Sbjct: 722 RVIKLDRGMSYFYPAEGLNPSDENSALVHYIQVHRDDFLPNVKLQLFALIAKQRAFHQLR 781
Query: 825 TKEQLGYIVFSGPRRANGIQGLRFIIQSE-KPPHYLESRVEAFLITMEKSIEDMTEEAFQ 883
+ EQLGYI R +GI+G++FIIQS K P +++SRV FL E + M+E+ F+
Sbjct: 782 SVEQLGYITVLMQRNDSGIRGVQFIIQSTVKGPGHIDSRVVEFLKMFESKLYAMSEDEFK 841
Query: 884 KHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEM 943
++ AL +L+K K L E YW EI FDR EVA LK LT++++I F+ E
Sbjct: 842 SNVNALIDMKLEKHKNLREESGFYWREIYDGTLKFDRREAEVAALKKLTQKELIDFFNEH 901
Query: 944 LAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLP 1003
+ V AP++ +SV V S + P+ I ++ +F++ P
Sbjct: 902 IKVGAPQKKTLSVRVYGGLHTSEYADEKKEANQ----------PKQVKIDDIFKFRKSQP 951
Query: 1004 LFPLVK 1009
L+ K
Sbjct: 952 LYGSFK 957
>ref|XP_748141.1| a-pheromone processing metallopeptidase Ste23 [Aspergillus fumigatus
Af293]
gb|EAL86103.1| a-pheromone processing metallopeptidase Ste23 [Aspergillus fumigatus
Af293]
Length = 1154
Score = 1050 bits (2715), Expect = 0.0, Method: Composition-based stats.
Identities = 393/1004 (39%), Positives = 595/1004 (59%), Gaps = 33/1004 (3%)
Query: 5 LAWLLHPALPSTFRSV-----LGARLPPPERLCG--FQKKTYSK----------MNNPAI 47
++ L P++ ST + L RL P+ L + + T + + +I
Sbjct: 25 RSFSLVPSIASTAIAPHFSSSLRRRLDCPQFLLSRCWPRHTLPRSTVAPFSTAAVTMGSI 84
Query: 48 KRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLS 107
+RI H+ K D R YR + L+N ++ LL+ DP TDK+SA+++V++G+ SD ++ G++
Sbjct: 85 QRITEHLEKPELDDRSYRVIRLSNKLEALLVHDPETDKASASVNVNVGNFSDADDMPGMA 144
Query: 108 HFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQ 167
H EH+LF+GTKK+PKEN Y+Q+L+ H+GSSNA+T+ TNY+F+ L GALDRFAQ
Sbjct: 145 HAVEHLLFMGTKKFPKENAYNQYLASHSGSSNAYTAATETNYFFE-PSSPLYGALDRFAQ 203
Query: 168 FFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLE 227
FF+ PLF ES DRE+ AVDSE++KN+ +D WRL QL K+ NP HP+ F TGN TL+
Sbjct: 204 FFVSPLFLESTLDRELRAVDSENKKNLQSDLWRLMQLNKSLSNPAHPYHHFSTGNLKTLK 263
Query: 228 TRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPE 287
P Q G++VR E +KF+ +YS+N M +CVLGRESLD+L V +LFSEVENK++P
Sbjct: 264 EDPQQRGLEVRSEFIKFYQKHYSANRMKLCVLGRESLDELEKWVEELFSEVENKDLPQNR 323
Query: 288 FP-EHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSL 346
+ P++ E L P+ D R+L + FP D + Y+S P Y+ HLIGHEGPGS+
Sbjct: 324 WDDVQPWRHEDLGIQIFAKPVMDTRSLDIYFPFLDEETLYESQPSRYISHLIGHEGPGSI 383
Query: 347 LSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGP 406
L+ +K+KGW N L G G F I++ LT+EGL ++ +FQYI L+ P
Sbjct: 384 LAYIKAKGWANGLSAGVMPICPGAAAFTISIRLTKEGLQQYREVAKVVFQYIAMLKEREP 443
Query: 407 QEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEM 466
Q+WVF E K++ V FRFK K +TS+++ ++ E L + LL +F PDLI+
Sbjct: 444 QQWVFDEMKNMAEVEFRFKQKSPASRFTSRLSSVMQKPLPREWLLSGSLLRKFDPDLIKK 503
Query: 467 VLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNA------DLNG 520
L LRP+N R+ +VS+ + G D E+WYGT+YK IP++ + + A
Sbjct: 504 ALSYLRPDNFRLIVVSQEYPGDWDSKEKWYGTEYKVGKIPEDFMADIREALDTTPETRLS 563
Query: 521 KFKLPTKNEFIPTNFEILPLE-KEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFF 579
+P KNEF+PT + E E P LI+ +LWFK+DD+F++PK ++
Sbjct: 564 DLHMPHKNEFVPTRLSVEKKEVSEPAKTPKLIRHDDHVRLWFKKDDRFWVPKGTVHITLR 623
Query: 580 SPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQP 639
+P A+ P + + LY EL+KD+L EY+Y AELAGL Y L +++G+ +SV GYNDK
Sbjct: 624 NPLAWATPANLVKSKLYCELVKDALVEYSYDAELAGLDYHLSASVFGLDVSVGGYNDKMA 683
Query: 640 ILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDE 699
+LL+K+ M ++ RF IIKE R N +QP Y R L +E W ++
Sbjct: 684 VLLEKVFTSMRDLVVNPNRFHIIKERLSRGYRNAEYQQPFYQVGDYTRYLTSEKTWINEQ 743
Query: 700 LKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLL 759
L+ + + +F PQLLS+ HIE L HGN+ K+ AL + +VE+ L ++PL
Sbjct: 744 YAAELEHIEAEDISSFFPQLLSQNHIEVLAHGNLYKEDALKMTDLVENIL----QSRPLP 799
Query: 760 PSQLVRYREVQLPDRGWFVYQQR--NEVHNNCGIEIYYQTDM-QSTSENMFLELFCQIIS 816
SQ R + +P F+Y++ + + N IE Y L LF Q+
Sbjct: 800 QSQWHVRRNIIIPPGSNFIYERTLRDPANINHCIEYYVYVGSITDDMLRAKLLLFAQMTD 859
Query: 817 EPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIED 876
EP F+ LR+KEQLGY+V+SG R + G R IIQSE+ YLESR++ FLI +++E+
Sbjct: 860 EPAFDQLRSKEQLGYVVWSGARYSATTIGYRVIIQSERTAEYLESRIDNFLIQTGETLEN 919
Query: 877 MTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDI 936
M+E+ F+ H +++ +RL+K K LS+E +++W I S+ ++F ++ ++ A ++ LTK DI
Sbjct: 920 MSEKDFEGHKRSVINKRLEKLKNLSSETSRFWSHIGSEYFDFLQNESDAANVRALTKADI 979
Query: 937 IKFYKEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINL 980
+ FYK+++ +P R K+S+++ A+ + G+ ++L
Sbjct: 980 VDFYKQLIDPRSPTRGKLSIYLNAQGGAHAKLEGKDQQSRLVSL 1023
>gb|EDP51051.1| a-pheromone processing metallopeptidase Ste23 [Aspergillus fumigatus
A1163]
Length = 1154
Score = 1049 bits (2712), Expect = 0.0, Method: Composition-based stats.
Identities = 393/1004 (39%), Positives = 595/1004 (59%), Gaps = 33/1004 (3%)
Query: 5 LAWLLHPALPSTFRSV-----LGARLPPPERLCG--FQKKTYSK----------MNNPAI 47
++ L P++ ST + L RL P+ L + + T + + +I
Sbjct: 25 RSFSLVPSIASTAIAPHFSSSLRRRLDCPQFLLSRCWPRHTLPRSTVAPFSTAAVTMGSI 84
Query: 48 KRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLS 107
+RI H+ K D R YR + L+N ++ LL+ DP TDK+SA+++V++G+ SD ++ G++
Sbjct: 85 QRITEHLEKPELDDRSYRVIRLSNKLEALLVHDPETDKASASVNVNVGNFSDADDMPGMA 144
Query: 108 HFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQ 167
H EH+LF+GTKK+PKEN Y+Q+L+ H+GSSNA+T+ TNY+F+ L GALDRFAQ
Sbjct: 145 HAVEHLLFMGTKKFPKENAYNQYLASHSGSSNAYTAATETNYFFE-PSSPLYGALDRFAQ 203
Query: 168 FFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLE 227
FF+ PLF ES DRE+ AVDSE++KN+ +D WRL QL K+ NP HP+ F TGN TL+
Sbjct: 204 FFVSPLFLESTLDRELRAVDSENKKNLQSDLWRLMQLNKSLSNPAHPYHHFSTGNLKTLK 263
Query: 228 TRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPE 287
P Q G++VR E +KF+ +YS+N M +CVLGRESLD+L V +LFSEVENK++P
Sbjct: 264 EDPQQRGLEVRSEFIKFYQKHYSANRMKLCVLGRESLDELEKWVEELFSEVENKDLPQNR 323
Query: 288 FP-EHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSL 346
+ P++ E L P+ D R++ + FP D + Y+S P Y+ HLIGHEGPGS+
Sbjct: 324 WDDVQPWRHEDLGIQIFAKPVMDTRSVDIYFPFLDEETLYESQPSRYISHLIGHEGPGSI 383
Query: 347 LSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGP 406
L+ +K+KGW N L G G F I++ LT+EGL ++ +FQYI L+ P
Sbjct: 384 LAYIKAKGWANGLSAGVMPICPGAAAFTISIRLTKEGLQQYREVAKVVFQYIAMLKEREP 443
Query: 407 QEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEM 466
Q+WVF E K+L V FRFK K +TS+++ ++ E L + LL +F PDLI+
Sbjct: 444 QQWVFDEMKNLAEVEFRFKQKSPASRFTSRLSSVMQKPLPREWLLSGSLLRKFDPDLIKK 503
Query: 467 VLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNA------DLNG 520
L LRP+N R+ +VS+ + G D E+WYGT+YK IP++ + + A
Sbjct: 504 ALSYLRPDNFRLIVVSQEYPGDWDSKEKWYGTEYKVGKIPEDFMADIREALDTTPETRLS 563
Query: 521 KFKLPTKNEFIPTNFEILPLE-KEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFF 579
+P KNEF+PT + E E P LI+ +LWFK+DD+F++PK ++
Sbjct: 564 DLHMPHKNEFVPTRLSVEKKEVSEPAKTPKLIRHDDHVRLWFKKDDRFWVPKGTVHITLR 623
Query: 580 SPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQP 639
+P A+ P + + LY EL+KD+L EY+Y AELAGL Y L +++G+ +SV GYNDK
Sbjct: 624 NPLAWATPANLVKSKLYCELVKDALVEYSYDAELAGLDYHLSASVFGLDVSVGGYNDKMA 683
Query: 640 ILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDE 699
+LL+K+ M ++ RF IIKE R N +QP Y R L +E W ++
Sbjct: 684 VLLEKVFTSMRDLVVNPNRFHIIKERLSRGYRNAEYQQPFYQVGDYTRYLTSEKTWINEQ 743
Query: 700 LKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLL 759
L+ + + +F PQLLS+ HIE L HGN+ K+ AL + +VE+ L ++PL
Sbjct: 744 YAAELEHIEAEDISSFFPQLLSQNHIEVLAHGNLYKEDALKMTDLVENIL----QSRPLP 799
Query: 760 PSQLVRYREVQLPDRGWFVYQQR--NEVHNNCGIEIYYQTDM-QSTSENMFLELFCQIIS 816
SQ R + +P F+Y++ + + N IE Y L LF Q+
Sbjct: 800 QSQWHVRRNIIIPPGSNFIYERTLRDPANINHCIEYYVYVGSITDDMLRAKLLLFAQMTD 859
Query: 817 EPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIED 876
EP F+ LR+KEQLGY+V+SG R + G R IIQSE+ YLESR++ FLI +++E+
Sbjct: 860 EPAFDQLRSKEQLGYVVWSGARYSATTIGYRVIIQSERTAEYLESRIDNFLIQTGETLEN 919
Query: 877 MTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDI 936
M+E+ F+ H +++ +RL+K K LS+E +++W I S+ ++F ++ ++ A ++ LTK DI
Sbjct: 920 MSEKDFEGHKRSVINKRLEKLKNLSSETSRFWSHIGSEYFDFLQNESDAANVRALTKADI 979
Query: 937 IKFYKEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINL 980
+ FYK+++ +P R K+S+++ A+ + G+ ++L
Sbjct: 980 VDFYKQLIDPRSPTRGKLSIYLNAQGGAHTKLEGKDQQSRLVSL 1023
>ref|XP_001266332.1| a-pheromone processing metallopeptidase Ste23 [Neosartorya fischeri
NRRL 181]
gb|EAW24435.1| a-pheromone processing metallopeptidase Ste23 [Neosartorya fischeri
NRRL 181]
Length = 1155
Score = 1049 bits (2712), Expect = 0.0, Method: Composition-based stats.
Identities = 391/1004 (38%), Positives = 593/1004 (59%), Gaps = 33/1004 (3%)
Query: 5 LAWLLHPALPSTFRSVLGARLPPPERLCG-------FQKKTYSK----------MNNPAI 47
++ L P++ ST + + P C + +++ S+ + +I
Sbjct: 26 RSFSLVPSIASTAIAPHFSSSPRRRLNCPQSLLSRCWSRRSLSRSTVAPFSAAAVTMGSI 85
Query: 48 KRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLS 107
+ I H+ K D R YR + L+N ++ LL+ DP TDK+SA+++V++G+ SD ++ G++
Sbjct: 86 QHITEHLEKPELDDRSYRVIRLSNKLEALLVHDPETDKASASVNVNVGNFSDADDMPGMA 145
Query: 108 HFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQ 167
H EH+LF+GTKK+PKEN Y+Q+L+ H+GSSNA+T+ TNY+F+ L GALDRFAQ
Sbjct: 146 HAVEHLLFMGTKKFPKENAYNQYLASHSGSSNAYTAATETNYFFE-PSSPLYGALDRFAQ 204
Query: 168 FFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLE 227
FF+ PLF ES DRE+ AVDSE++KN+ +D WRL QL K+ NP HP+ F TGN TL+
Sbjct: 205 FFVSPLFLESTLDRELRAVDSENKKNLQSDLWRLMQLNKSLSNPAHPYHHFSTGNLKTLK 264
Query: 228 TRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPE 287
P Q G++VR E +KF+ +YS+N M +CVLGRESLD+L V +LFSEVENK++P
Sbjct: 265 EDPQQRGLEVRSEFIKFYQKHYSANRMRLCVLGRESLDELEKWVEELFSEVENKDLPQNR 324
Query: 288 FP-EHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSL 346
+ P+++E L P+ D R+L + FP D + Y+S P Y+ HLIGHEGPGS+
Sbjct: 325 WDDVQPWRDEDLGIQIFAKPVMDTRSLDIYFPFLDEETLYESQPSRYISHLIGHEGPGSI 384
Query: 347 LSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGP 406
L+ +K+KGW N L G G F I++ LT+EGL ++ +FQYI L+ P
Sbjct: 385 LAYIKAKGWANGLSAGVMPICPGAAAFTISIRLTKEGLQQYREVAKVVFQYIAMLKEREP 444
Query: 407 QEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEM 466
Q+WVF E K+L V FRFK K +TS+++ ++ E L + LL +F PDLI+
Sbjct: 445 QQWVFDEMKNLAEVEFRFKQKSPASRFTSRLSSVMQKPLPREWLLSGSLLRKFDPDLIKK 504
Query: 467 VLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNA------DLNG 520
L LRP+N R+ +VS+ + G + E+WYGT+YK IP + + + A
Sbjct: 505 ALSYLRPDNFRLIVVSQEYPGDWNSKEKWYGTEYKVGKIPQDFMADIREALDSTPETRLS 564
Query: 521 KFKLPTKNEFIPTNFEILPLE-KEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFF 579
+ +P KNEF+PT + E E P LI+ +LWFK+DD+F++PK ++
Sbjct: 565 ELHMPHKNEFVPTRLSVEKKEVAEPAKTPKLIRHDDHVRLWFKKDDRFWVPKGTVHITLR 624
Query: 580 SPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQP 639
+P A+ P + + LY EL+KD+L EY+Y AELAGL Y L +++G+ +SV GYNDK
Sbjct: 625 NPLAWATPANLVKSKLYCELVKDALVEYSYDAELAGLDYHLSASVFGLDVSVGGYNDKMA 684
Query: 640 ILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDE 699
+LL+K+ M ++ RF IIKE R N +QP Y R L +E W ++
Sbjct: 685 VLLEKVFTSMRDLVVNPNRFHIIKERLSRGYRNAEYQQPFYQVGDYTRYLTSEKTWINEQ 744
Query: 700 LKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLL 759
L+ + + F PQLLS+ HIE L HGN+ K+ AL + +VE+ L ++PL
Sbjct: 745 YAAELEHIDAEDISNFFPQLLSQNHIEVLAHGNLYKEDALKMTDLVENIL----QSRPLP 800
Query: 760 PSQLVRYREVQLPDRGWFVYQQR--NEVHNNCGIEIYYQTDM-QSTSENMFLELFCQIIS 816
SQ R + +P +VY++ + + N IE Y L LF Q+
Sbjct: 801 QSQWHVRRNIIIPPGSNYVYERTLRDPANINHCIEYYVYVGSITDDMLRAKLLLFAQMTD 860
Query: 817 EPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIED 876
EP F+ LR+KEQLGY+V+SG R + G R IIQSE+ YLESR++ FLI +++E+
Sbjct: 861 EPAFDQLRSKEQLGYVVWSGARYSATTIGYRVIIQSERTAEYLESRIDNFLIQTGETLEN 920
Query: 877 MTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDI 936
M+E+ F+ H +++ +RL+K K LS+E +++W I S+ ++F ++ ++ A ++ LTK DI
Sbjct: 921 MSEKDFEGHKRSVINKRLEKLKNLSSETSRFWSHIGSEYFDFLQNESDAANVRALTKADI 980
Query: 937 IKFYKEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINL 980
+ FYK++L +P R K+S+++ A+ V G+ ++L
Sbjct: 981 VDFYKQLLDPRSPTRGKLSIYLNAQGGAHAKVEGKDQQSRLVSL 1024
>ref|NP_181710.1| peptidase M16 family protein / insulinase family protein [Arabidopsis
thaliana]
gb|AAC02769.1| putative zinc protease [Arabidopsis thaliana]
Length = 970
Score = 1048 bits (2711), Expect = 0.0, Method: Composition-based stats.
Identities = 367/963 (38%), Positives = 546/963 (56%), Gaps = 19/963 (1%)
Query: 53 HITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEH 112
I K D REYR + L N ++VLLISDP TDK +A++ V +GS SDP + GL+HF EH
Sbjct: 14 EILKPRTDNREYRMIVLKNLLQVLLISDPDTDKCAASMSVSVGSFSDPQGLEGLAHFLEH 73
Query: 113 MLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCP 172
MLF ++KYP+E+ YS++++EH GS+NA+T+ E TNY+FDV+ + + ALDRFAQFF+ P
Sbjct: 74 MLFYASEKYPEEDSYSKYITEHGGSTNAYTASEETNYHFDVNADCFDEALDRFAQFFIKP 133
Query: 173 LFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQ 232
L RE+ AVDSE++KN+++D WR+ QL+K HP+ KF TGN TL RP
Sbjct: 134 LMSADATMREIKAVDSENQKNLLSDGWRIRQLQKHLSKEDHPYHKFSTGNMDTLHVRPQA 193
Query: 233 EGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHP 292
+G+D R EL+KF+ +YS+N+M + V G+ESLD + +LV ++F E++N N +P FP P
Sbjct: 194 KGVDTRSELIKFYEEHYSANIMHLVVYGKESLDKIQDLVERMFQEIQNTNKVVPRFPGQP 253
Query: 293 FQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKS 352
+HL+ L K +PIK L V++P+ +Y P YLGHLIGHEG GSL LK+
Sbjct: 254 CTADHLQILVKAIPIKQGHKLGVSWPVTPSIHHYDEAPSQYLGHLIGHEGEGSLFHALKT 313
Query: 353 KGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQ 412
GW L G+ E + FF +++DLT+ G H+++I+ +F YIQ L+ G +W+F
Sbjct: 314 LGWATGLSAGEGEWTLDYSFFKVSIDLTDAGHEHMQEILGLLFNYIQLLQQTGVCQWIFD 373
Query: 413 ECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLR 472
E + F ++DK P Y IA + YP ++ L L +F P +++ V+D+L
Sbjct: 374 ELSAICETKFHYQDKIPPMSYIVDIASNMQIYPTKDWLVGSSLPTKFNPAIVQKVVDELS 433
Query: 473 PENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIP 532
P N R+ S+ FEG+TD+ E WY T Y E I I++W + + LP N FIP
Sbjct: 434 PSNFRIFWESQKFEGQTDKAEPWYNTAYSLEKITSSTIQEWVQSAPDVHLHLPAPNVFIP 493
Query: 533 TNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNM 592
T+ + + + T P L++ T S+LW+K D F PKA + +F P A P +
Sbjct: 494 TDLSLKDADDKET-VPVLLRKTPFSRLWYKPDTMFSKPKAYVKMDFNCPLAVSSPDAAVL 552
Query: 593 AYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATF 652
++ LL D LNEYAY A++AGL Y + + G L++ GYN K ILL+ ++ K+A F
Sbjct: 553 TDIFTRLLMDYLNEYAYYAQVAGLYYGVSLSDNGFELTLLGYNHKLRILLETVVGKIANF 612
Query: 653 EIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRL 712
E+ RF +IKE + N++ QP+ AMYY L++ + W E + L + +
Sbjct: 613 EVKPDRFAVIKETVTKEYQNYKFRQPYHQAMYYCSLILQDQTWPWTEELDVLSHLEAEDV 672
Query: 713 KAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAH--TKPLLPSQLVRYREVQ 770
F+P LLSR IE + GN+ A +++ +ED L +PL PSQ + R V+
Sbjct: 673 AKFVPMLLSRTFIECYIAGNVENNEAESMVKHIEDVLFNDPKPICRPLFPSQHLTNRVVK 732
Query: 771 LPDRGWFVYQQR--NEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQ 828
L + + Y Q N N + Y Q S N+ L+LF + + F+ LRT EQ
Sbjct: 733 LGEGMKYFYHQDGSNPSDENSALVHYIQVHRDDFSMNIKLQLFGLVAKQATFHQLRTVEQ 792
Query: 829 LGYIVFSGPRRANGIQGLRFIIQSE-KPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQ 887
LGYI R +GI G++FIIQS K P +++SRVE+ L E + +M+ E F+ ++
Sbjct: 793 LGYITALAQRNDSGIYGVQFIIQSSVKGPGHIDSRVESLLKNFESKLYEMSNEDFKSNVT 852
Query: 888 ALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVD 947
AL +L+K K L E YW EI S F+R EV+ LK L K+++I F+ E + V
Sbjct: 853 ALIDMKLEKHKNLKEESRFYWREIQSGTLKFNRKEAEVSALKQLQKQELIDFFDEYIKVG 912
Query: 948 APRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEV-IQNMTEFKRGLPLFP 1006
A R+ +S+ V + + +P P V I+++ F++ PL
Sbjct: 913 AARKKSLSIRVYGSQHLKEMASDK------------DEVPSPSVEIEDIVGFRKSQPLHG 960
Query: 1007 LVK 1009
+
Sbjct: 961 SFR 963
>dbj|BAE98754.1| putative zinc protease [Arabidopsis thaliana]
Length = 970
Score = 1047 bits (2709), Expect = 0.0, Method: Composition-based stats.
Identities = 367/963 (38%), Positives = 546/963 (56%), Gaps = 19/963 (1%)
Query: 53 HITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEH 112
I K D REYR + L N ++VLLISDP TDK +A++ V +GS SDP + GL+HF EH
Sbjct: 14 EILKPRTDNREYRMIVLKNLLQVLLISDPDTDKCAASMSVSVGSFSDPQGLEGLAHFLEH 73
Query: 113 MLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCP 172
MLF ++KYP+E+ YS++++EH GS+NA+T+ E TNY+FDV+ + + ALDRFAQFF+ P
Sbjct: 74 MLFYASEKYPEEDSYSKYITEHGGSTNAYTASEETNYHFDVNADCFDEALDRFAQFFIKP 133
Query: 173 LFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQ 232
L RE+ AVDSE++KN+++D WR+ QL+K HP+ KF TGN TL RP
Sbjct: 134 LMSADATMREIKAVDSENQKNLLSDGWRIRQLQKHLSKEDHPYHKFSTGNMDTLHVRPQA 193
Query: 233 EGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHP 292
+G+D R EL+KF+ +YS+N+M + V G+ESLD + +LV ++F E++N N +P FP P
Sbjct: 194 KGVDTRSELIKFYEEHYSANIMHLVVYGKESLDKIQDLVERMFQEIQNTNKVVPRFPGQP 253
Query: 293 FQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKS 352
+HL+ L K +PIK L V++P+ +Y P YLGHLIGHEG GSL LK+
Sbjct: 254 CTADHLQILVKAIPIKQGHKLGVSWPVTPSIHHYDEAPSQYLGHLIGHEGEGSLFHALKT 313
Query: 353 KGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQ 412
GW L G+ E + FF +++DLT+ G H+++I+ +F YIQ L+ G +W+F
Sbjct: 314 LGWATGLSAGEGEWTLDYSFFKVSIDLTDAGHEHMQEILGLLFNYIQLLQQTGVCQWIFD 373
Query: 413 ECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLR 472
E + F ++DK P Y IA + YP ++ L L +F P +++ V+D+L
Sbjct: 374 ELSAICETKFHYQDKIPPMSYIVDIASNMQIYPTKDWLVGSSLPTKFNPAIVQKVVDELS 433
Query: 473 PENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIP 532
P N R+ S+ FEG+TD+ E WY T Y E I I++W + + LP N FIP
Sbjct: 434 PSNFRIFWESQKFEGQTDKAEPWYNTAYSLEKITSSTIQEWVQSAPDVHLHLPAPNVFIP 493
Query: 533 TNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNM 592
T+ + + + T P L++ T S+LW+K D F PKA + +F P A P +
Sbjct: 494 TDLSLKDADDKET-VPVLLRKTPFSRLWYKPDTMFSKPKAYVKMDFNCPLAVSSPDAAVL 552
Query: 593 AYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATF 652
++ LL D LNEYAY A++AGL Y + + G L++ GYN K ILL+ ++ K+A F
Sbjct: 553 TDIFTRLLMDYLNEYAYYAQVAGLYYGVSLSDNGFELTLLGYNHKLRILLETVVGKIANF 612
Query: 653 EIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRL 712
E+ RF +IKE + N++ QP+ AMYY L++ + W E + L + +
Sbjct: 613 EVKPDRFAVIKETVTKEYQNYKFRQPYHQAMYYCSLILQDQTWPWTEELDVLSHLEAEDV 672
Query: 713 KAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAH--TKPLLPSQLVRYREVQ 770
F+P LLSR IE + GN+ A +++ +ED L +PL PSQ + R V+
Sbjct: 673 AKFVPMLLSRTFIECYIAGNVENNEAESMVKHIEDVLFNDPKPICRPLFPSQRLTNRVVK 732
Query: 771 LPDRGWFVYQQR--NEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQ 828
L + + Y Q N N + Y Q S N+ L+LF + + F+ LRT EQ
Sbjct: 733 LGEGMKYFYHQDGSNPSDENSALVHYIQVHRDDFSMNIKLQLFGLVAKQATFHQLRTVEQ 792
Query: 829 LGYIVFSGPRRANGIQGLRFIIQSE-KPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQ 887
LGYI R +GI G++FIIQS K P +++SRVE+ L E + +M+ E F+ ++
Sbjct: 793 LGYITALAQRNDSGIYGVQFIIQSSVKGPGHIDSRVESLLKNFESKLYEMSNEDFKSNVT 852
Query: 888 ALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVD 947
AL +L+K K L E YW EI S F+R EV+ LK L K+++I F+ E + V
Sbjct: 853 ALIDMKLEKHKNLKEESRFYWREIQSGTLKFNRKEAEVSALKQLQKQELIDFFDEYIKVG 912
Query: 948 APRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEV-IQNMTEFKRGLPLFP 1006
A R+ +S+ V + + +P P V I+++ F++ PL
Sbjct: 913 AARKKSLSIRVYGSQHLKEMASDK------------DEVPSPSVEIEDIVGFRKSQPLHG 960
Query: 1007 LVK 1009
+
Sbjct: 961 SFR 963
>sp|P22817|IDE_DROME Insulin-degrading enzyme (Insulysin) (Insulinase) (Insulin protease)
Length = 990
Score = 1047 bits (2709), Expect = 0.0, Method: Composition-based stats.
Identities = 454/985 (46%), Positives = 654/985 (66%), Gaps = 8/985 (0%)
Query: 33 GFQKKTYSKMNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDV 92
QK K ++ N+I KS +D R+YRGL+L NG+KVLLISDP TD S+AAL V
Sbjct: 6 SSQKSATRKPDSMEPILRLNNIEKSLQDTRDYRGLQLENGLKVLLISDPNTDVSAAALSV 65
Query: 93 HIGSLSDPPNIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFD 152
+G +SDP N+ GL+HFCEHMLFLGT+KYP EN Y+ +LS+ GSSNA T T Y+F
Sbjct: 66 QVGHMSDPTNLPGLAHFCEHMLFLGTEKYPHENGYTTYLSQSGGSSNAATYPLMTKYHFH 125
Query: 153 VSHEHLEGALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPK 212
V+ + L+GALDRFAQFF+ PLF S +RE+NAV+SEHEKN+ +D WR+ Q+ + P
Sbjct: 126 VAPDKLDGALDRFAQFFIAPLFTPSATEREINAVNSEHEKNLPSDLWRIKQVNRHLAKPD 185
Query: 213 HPFSKFGTGNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVV 272
H +SKFG+GNK TL P + IDVR ELLKFH +YS+N+M + V+G+ESLD+L +V+
Sbjct: 186 HAYSKFGSGNKTTLSEIPKSKNIDVRDELLKFHKQWYSANIMCLAVIGKESLDELEGMVL 245
Query: 273 KLFSEVENKNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGH 332
+ FSE+ENKNV +P +P HP+ EE Q KIVPIKDIR+L ++F DL ++YKS P +
Sbjct: 246 EKFSEIENKNVKVPGWPRHPYAEERYGQKVKIVPIKDIRSLTISFTTDDLTQFYKSGPDN 305
Query: 333 YLGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIIL 392
YL HLIGHEG GS+LSEL+ GW N L+ G + GF FF I VDLT+EGL HV+DI+
Sbjct: 306 YLTHLIGHEGKGSILSELRRLGWCNDLMAGHQNTQNGFGFFDIVVDLTQEGLEHVDDIVK 365
Query: 393 HMFQYIQKLRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTA 452
+FQY++ LR EGP++W+F EC LN + FRFK+KE+P + + +PLEEVL A
Sbjct: 366 IVFQYLEMLRKEGPKKWIFDECVKLNEMRFRFKEKEQPENLVTHAVSSMQIFPLEEVLIA 425
Query: 453 EYLLEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKK 512
YL E+RPDLI+ +LD+L P R+ IVS+SFE D E +Y T+Y + + ++
Sbjct: 426 PYLSNEWRPDLIKGLLDELVPSKSRIVIVSQSFEPDCDLAEPYYKTKYGITRVAKDTVQS 485
Query: 513 WQNADLNGKFKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKA 572
W+N +LN KL N FIPTNF+I + +A +P +I DT + ++W KQD++F PKA
Sbjct: 486 WENCELNENLKLALPNSFIPTNFDISDVPADAPKHPTIILDTPILRVWHKQDNQFNKPKA 545
Query: 573 CLNFEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVK 632
C+ F+ +P AY+DPL+CN+ ++ + LLKD LNEY Y AELA L + G+ +++
Sbjct: 546 CMTFDMSNPIAYLDPLNCNLNHMMVMLLKDQLNEYLYDAELASLKLSVMGKSCGIDFTIR 605
Query: 633 GYNDKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTE 692
G++DKQ +LL+K+++ + F IDEKRF+I+KE Y+RSL NF+AEQP+QH++YYL LL+TE
Sbjct: 606 GFSDKQVVLLEKLLDHLFDFSIDEKRFDILKEEYVRSLKNFKAEQPYQHSIYYLALLLTE 665
Query: 693 VAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTL-IE 751
AW EL +A++ VT R+ F + RLH E + GN+TKQ A I V L
Sbjct: 666 NAWANMELLDAMELVTYDRVLNFAKEFFQRLHTECFIFGNVTKQQATDIAGRVNTRLEAT 725
Query: 752 HAHTKPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELF 811
+A P+L Q+++ RE +L +++++ NE H + ++Y Q Q+ N+ + L
Sbjct: 726 NASKLPILARQMLKKREYKLLAGDSYLFEKENEFHKSSCAQLYLQCGAQTDHTNIMVNLV 785
Query: 812 CQIISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITME 871
Q++SEPC++ LRTKEQLGYIVFSG R+ NG G+R I+QS K P Y+E R+E FL T
Sbjct: 786 SQVLSEPCYDCLRTKEQLGYIVFSGVRKVNGANGIRIIVQSAKHPSYVEDRIENFLQTYL 845
Query: 872 KSIEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTL 931
+ IEDM + F++H +ALA+++L+KPK + + ++++GEI Q Y+F+R+ EVA L+ +
Sbjct: 846 QVIEDMPLDEFERHKEALAVKKLEKPKTIFQQFSQFYGEIAMQTYHFEREEAEVAILRKI 905
Query: 932 TKEDIIKFYKEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEV 991
+K D + ++K+ +A D R +SVH+++++ D P + + + +
Sbjct: 906 SKADFVDYFKKFIAKDGEERRVLSVHIVSQQTDENATSEAEPVE-------ITNMERHKP 958
Query: 992 IQNMTEFKRGLPLFPLVKPHINFMA 1016
I ++ FK L+P+ P ++ A
Sbjct: 959 ISDIVTFKSCKELYPIALPFLDIKA 983
>ref|XP_001276340.1| a-pheromone processing metallopeptidase Ste23 [Aspergillus clavatus
NRRL 1]
gb|EAW14914.1| a-pheromone processing metallopeptidase Ste23 [Aspergillus clavatus
NRRL 1]
Length = 1156
Score = 1047 bits (2707), Expect = 0.0, Method: Composition-based stats.
Identities = 384/1027 (37%), Positives = 590/1027 (57%), Gaps = 33/1027 (3%)
Query: 2 RYRLAWLLH-----PALPSTFRSVLGARLP---PP-----ERLCGFQKK----TYSKMNN 44
RY + L A+ F S L R P R + + +
Sbjct: 23 RYFPSLSLVSTLASAAIAPPFSSSLRLRPICSLHPLPGSWTRRSFSRSACAPFSAGNLTM 82
Query: 45 PAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIA 104
+I+ + + K D R YR + L N ++ LL+ DP TDK+SA+++V++G+ SD ++
Sbjct: 83 GSIEHLTESLEKPELDDRSYRVIRLPNKLEALLVHDPDTDKASASVNVNVGNFSDADDMP 142
Query: 105 GLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDR 164
G++H EH+LF+GTKK+PKEN Y+Q+L+ H+GSSNA+T+ TNY+F+ L GALDR
Sbjct: 143 GMAHAVEHLLFMGTKKFPKENAYNQYLASHSGSSNAYTAATETNYFFE-PSSPLYGALDR 201
Query: 165 FAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKY 224
FAQFF+ PLF ES DRE+ AVDSE++KN+ +D WRL QL K+ NP HP+ F TGN
Sbjct: 202 FAQFFVSPLFLESTLDRELRAVDSENKKNLQSDLWRLMQLNKSLSNPGHPYHHFSTGNLK 261
Query: 225 TLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVP 284
TL+ P + G++VR E +KF+ +YS+N M +CVLGRESLD+L V +LFSEVENK++P
Sbjct: 262 TLKEDPEKRGLEVRSEFIKFYEKHYSANRMRLCVLGRESLDELEKWVEELFSEVENKDLP 321
Query: 285 LPEFP-EHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGP 343
+ P++ E L P+ D R+L + FP D + Y+S P Y+ HLIGHEGP
Sbjct: 322 QNRWDDVQPWRPEDLGVQIFAKPVMDNRSLDIYFPFLDEEYLYESQPSRYISHLIGHEGP 381
Query: 344 GSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRA 403
GS+L+ +K+KGW N L G G F I++ LT+EGL ++ +F+YI L+
Sbjct: 382 GSILAYIKAKGWANGLSAGVMPICPGSAAFTISIRLTKEGLQQYREVAKVVFEYIAMLKE 441
Query: 404 EGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDL 463
PQ+WVF E K+L V FRFK K +TS+++ ++ E L + LL +F P+L
Sbjct: 442 REPQQWVFDEMKNLAEVEFRFKQKSPASRFTSRLSSVMQKPMPREWLLSGSLLRKFDPEL 501
Query: 464 IEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNA------D 517
I+ L L+P+N R+ +VS+ G D E+WYGT+YK + +P + + +NA
Sbjct: 502 IKKALACLQPDNFRMIVVSQEHPGDWDSKEKWYGTEYKVQKLPQDFMADIKNALATTPET 561
Query: 518 LNGKFKLPTKNEFIPTNFEILPLE-KEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNF 576
+ +P +NEF+PT + + E P LI+ +LWFK+DD+F++PK ++
Sbjct: 562 RLSELHMPHENEFVPTRLSVEKKDISEPAKTPKLIRHDEHVRLWFKKDDRFWVPKGTVHI 621
Query: 577 EFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYND 636
+P A+ P + + LY EL+KD+L EY+Y AELAGL Y L +++G+ +SV GYND
Sbjct: 622 TLRNPLAWATPANLVKSKLYCELVKDALVEYSYDAELAGLDYHLSASVFGLDISVGGYND 681
Query: 637 KQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWT 696
K +LL+K++ M ++ RF IIKE R N +QP Y R L E W
Sbjct: 682 KMAVLLEKVLTSMRDLVVNPDRFHIIKERLSRGYRNAEYQQPFYQVGDYTRHLTAEKTWI 741
Query: 697 KDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTK 756
++ L+ + + F PQLL + H+E L HGN+ K+ AL + +VE+ L ++
Sbjct: 742 NEQYAAELEHIEPEDISNFFPQLLQQNHVEVLAHGNLYKEDALRMTDLVENVL----QSR 797
Query: 757 PLLPSQLVRYREVQLPDRGWFVYQQ--RNEVHNNCGIEIYYQTDM-QSTSENMFLELFCQ 813
PL SQ R + +P +VY++ ++ + N IE Y + L LF Q
Sbjct: 798 PLPQSQWHVRRNIIIPPGSNYVYERTLQDPANVNHCIEYYVYVGSIRDDILRAKLLLFAQ 857
Query: 814 IISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKS 873
+ EP F+ LR+KEQLGY+V+SG R + G R IIQSE+ YLESR++ FLI ++
Sbjct: 858 MTDEPAFDQLRSKEQLGYVVWSGARYSATTIGYRVIIQSERTAEYLESRIDNFLIQAGET 917
Query: 874 IEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTK 933
+E+M+++ F+ H +++ +RL+K K LS+E +++W I S+ ++F ++ T+ A ++TLTK
Sbjct: 918 LENMSDKDFEGHKRSVVNKRLEKLKNLSSETSRFWSHIGSEYFDFVQNETDAANVRTLTK 977
Query: 934 EDIIKFYKEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQ 993
DI+ FYK+++ +P R K+S+++ A+ + ++ + L
Sbjct: 978 ADIVDFYKQLIDPRSPTRGKLSIYLNAQAGGHTHTIDPKEQRSQLVSLFGKQLETAGFAV 1037
Query: 994 NMTEFKR 1000
+ F
Sbjct: 1038 DTERFGS 1044
>ref|XP_311589.4| AGAP010351-PA [Anopheles gambiae str. PEST]
gb|EAA07246.4| AGAP010351-PA [Anopheles gambiae str. PEST]
Length = 1030
Score = 1044 bits (2700), Expect = 0.0, Method: Composition-based stats.
Identities = 448/994 (45%), Positives = 646/994 (64%), Gaps = 10/994 (1%)
Query: 23 ARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPT 82
+ + +L N +RI N ITKS +D R+YRGL L+NG+KV+LISDPT
Sbjct: 38 SEIAGKAQLSNASTSLPQSTANMPFERI-NTITKSVQDNRDYRGLRLSNGMKVILISDPT 96
Query: 83 TDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFT 142
TD+S+AAL V +G LSDP I GL+H CEHMLFLGT+KYPKE+EY+ FL H GSSNA T
Sbjct: 97 TDRSAAALSVAVGHLSDPLQIPGLAHLCEHMLFLGTEKYPKEDEYTAFLKVHGGSSNAAT 156
Query: 143 SGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLF 202
+ T YYFDV LE ALDRF+QFF+ PLF+E +RE+NAV+SEHEKN+ D WR+
Sbjct: 157 CSDMTKYYFDVIPSKLEDALDRFSQFFIAPLFNEEVTEREINAVNSEHEKNLSQDVWRVK 216
Query: 203 QLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRE 262
Q+ KA HP+++FGTGNK TL P I+VR EL+ FH+ +YSSN+M++ V G+E
Sbjct: 217 QVNKALCKSTHPYNQFGTGNKQTLSESPKLNSINVRNELMTFHNKWYSSNIMSLAVFGQE 276
Query: 263 SLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDL 322
SLDDL LV+K FS++ENK V P +P+ P+ ++ L I+P+KD R+L ++F + DL
Sbjct: 277 SLDDLEALVIKFFSQIENKQVVAPRWPDMPYGDDQLNTKTYIIPVKDTRSLTISFQMEDL 336
Query: 323 QKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEE 382
++YYK+ P HY+ HLIGHEG GS+LSELK++GW N L+ G RGF F + VDLTE+
Sbjct: 337 EQYYKAGPEHYVSHLIGHEGKGSILSELKARGWCNKLISGYCSLGRGFGSFDVMVDLTED 396
Query: 383 GLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILH 442
G H++D + +FQYI LR + PQ+W+F+E +L + FRFKDKE P + + +H
Sbjct: 397 GFNHIDDTVKLIFQYINMLRVKKPQKWIFEEYCNLCEMLFRFKDKEGPTTLVTNVVSSMH 456
Query: 443 YYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQ 502
+PLE+VL A L+ E+RPDL+E ++ KL P+ R+ IV + E + E WYGT+Y
Sbjct: 457 LFPLEDVLVAHCLITEWRPDLVEDLISKLTPDKARLIIVGQKCESLANAEERWYGTKYGV 516
Query: 503 EAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFK 562
I V++ W DLN LP N FIPT+FE+LP++ +P +I+DT + + WFK
Sbjct: 517 YKIEPSVLEYWSTPDLNDNLSLPEPNPFIPTDFELLPIDSGIENFPIVIQDTPIIRTWFK 576
Query: 563 QDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQN 622
QD +F PKA ++F+F SP Y +PL+CN+ L+++LLKD LNE+ + A+LAGL + + N
Sbjct: 577 QDVEFLKPKALMSFDFNSPIVYSNPLNCNLTRLFVQLLKDHLNEFLFEADLAGLGFGVSN 636
Query: 623 TIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHA 682
T G+ LS+ GY+ KQ ILL+K+++ M F+ID +RFEI+KE Y+R L N++ EQP+QHA
Sbjct: 637 TTSGISLSIGGYSHKQVILLEKVLDNMFNFKIDRRRFEILKEQYIRGLKNYQTEQPYQHA 696
Query: 683 MYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIM 742
+YYL LL+TE AWT+ EL ++ +++ RL+ F+ QLLS++H+E ++GN+ K+ AL +
Sbjct: 697 IYYLALLLTEQAWTRQELLDSTQLLSIERLQLFLEQLLSQMHVECFIYGNVNKEKALLMT 756
Query: 743 QMVEDTLIE-HAHTKPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQS 801
++VED + A PLL QL+ RE +L F+++ NE H + +E+Y Q Q
Sbjct: 757 KLVEDKMKSTDAKLVPLLARQLLPKREYKLGTGESFLFEATNEFHKSSCMELYLQCGQQE 816
Query: 802 TSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLES 861
F+++ Q++SE C+ LRTKEQLGY+VF G R+ANGI GLR I+QS + P Y+E
Sbjct: 817 PHS-TFVDILSQLLSEGCYTQLRTKEQLGYLVFCGSRKANGICGLRIIVQSPRHPSYVEE 875
Query: 862 RVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRD 921
R+E FL +E+M E F +H +AL L+KPK+L + Y EI +QY+F+R
Sbjct: 876 RIENFLNNTLDYLENMAECEFNRHKEALVALLLEKPKRLVTQFNIYLQEISLRQYHFNRA 935
Query: 922 NTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLS 981
+ E L+TLTK+ +I +YKE + + +P R +SV V++ + + +
Sbjct: 936 HVEAEKLRTLTKQQVIDYYKEHIILGSPSRSTLSVRVISTASGGAE-------NSPVAEN 988
Query: 982 QAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFM 1015
+ ++ FK L+PL +P++ M
Sbjct: 989 FRTTKKDFIRVTDLASFKSSRSLYPLAQPYMEIM 1022
>gb|AAA28439.1| insulin-degrading enzyme
Length = 990
Score = 1043 bits (2697), Expect = 0.0, Method: Composition-based stats.
Identities = 451/985 (45%), Positives = 650/985 (65%), Gaps = 8/985 (0%)
Query: 33 GFQKKTYSKMNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDV 92
QK K ++ N+I KS +D R+YRGL+L NG+KVLLISDP TD S+AAL V
Sbjct: 6 SSQKSVTRKPDSMEPILRLNNIEKSLQDTRDYRGLQLENGLKVLLISDPNTDVSAAALSV 65
Query: 93 HIGSLSDPPNIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFD 152
+G +SDP N+ GL+HFCEHMLFLGT+KYP EN Y+ +LS+ GSSNA T T Y+F
Sbjct: 66 QVGHMSDPTNLPGLAHFCEHMLFLGTEKYPHENGYTTYLSQSGGSSNAATYPLMTKYHFH 125
Query: 153 VSHEHLEGALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPK 212
V+ + L+GALDRFAQFF+ PLF S +RE+NAV+SEHEKN+ +D WR+ Q+ + P
Sbjct: 126 VAPDKLDGALDRFAQFFIAPLFTPSATEREINAVNSEHEKNLPSDLWRIKQVNRHLAKPD 185
Query: 213 HPFSKFGTGNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVV 272
H +SKFG+GNK TL P + IDVR ELLKFH +YS+N+M + V+G+ESLD+L +V+
Sbjct: 186 HAYSKFGSGNKTTLSEIPKSKNIDVRDELLKFHKQWYSANIMCLAVIGKESLDELEGMVL 245
Query: 273 KLFSEVENKNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGH 332
+ FSE+ENKNV +P +P HP+ EE Q KIVPIKDIR+L ++F DL ++YKS P +
Sbjct: 246 EKFSEIENKNVKVPGWPRHPYAEERYGQKVKIVPIKDIRSLTISFTTDDLTQFYKSGPDN 305
Query: 333 YLGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIIL 392
YL HLIGHEG GS+LSEL+ GW N L+ G + GF FF I VDLT+EGL HV+DI+
Sbjct: 306 YLTHLIGHEGKGSILSELRRLGWCNDLMAGHQNTQNGFGFFDIVVDLTQEGLEHVDDIVK 365
Query: 393 HMFQYIQKLRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTA 452
+FQY++ LR EGP++W+ EC LN + FRFK+KE + + +PLEEVL A
Sbjct: 366 IVFQYLEMLRKEGPKKWILDECVKLNEMRFRFKEKEESENLVTHAVSSMKIFPLEEVLIA 425
Query: 453 EYLLEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKK 512
YL E+ PDLI+ +LD+L P R+ IVS+SFE D E +Y T+Y + + ++
Sbjct: 426 PYLSNEWSPDLIKGLLDELVPSKSRIVIVSQSFEPDCDLAEPYYKTKYGITRVAKDTVQS 485
Query: 513 WQNADLNGKFKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKA 572
W+N +LN KL N FIPTNF+I + +A +P +I DT + ++W KQD++F PKA
Sbjct: 486 WENCELNENLKLALPNSFIPTNFDISDVPADAPKHPTIILDTPILRVWHKQDNQFNKPKA 545
Query: 573 CLNFEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVK 632
C+ F+ +P AY+DPL+CN+ ++ + LLKD LNEY Y AELA L + G+ +++
Sbjct: 546 CMTFDMSNPIAYLDPLNCNLNHMMVMLLKDQLNEYLYDAELASLKLSVMGKSCGIDFTIR 605
Query: 633 GYNDKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTE 692
G++DKQ +LL+K+++ + F IDEKRF+I+KE Y+RSL NF+AEQP+QH++YYL LL+TE
Sbjct: 606 GFSDKQVVLLEKLLDHLFDFSIDEKRFDILKEEYVRSLKNFKAEQPYQHSIYYLALLLTE 665
Query: 693 VAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTL-IE 751
AW EL +A++ VT R+ F + RLH E + GN+TKQ A I V L
Sbjct: 666 NAWANMELLDAMELVTYDRVLNFAKEFFQRLHTECFIFGNVTKQQATDIAGRVNTRLEAT 725
Query: 752 HAHTKPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELF 811
+A P+L Q+++ RE +L +++++ NE H + ++Y Q Q+ N+ + L
Sbjct: 726 NASKLPILARQMLKKREYKLLAGDSYLFEKENEFHKSSCAQLYLQCGAQTDHTNIMVNLV 785
Query: 812 CQIISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITME 871
Q++SEPC++ LRTKEQLGYIVFSG R+ NG G+R I+QS K P Y+E R+E FL T
Sbjct: 786 SQVLSEPCYDCLRTKEQLGYIVFSGVRKVNGANGIRIIVQSAKHPSYVEDRIENFLQTYL 845
Query: 872 KSIEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTL 931
+ IEDM + F++H +ALA+++L+KPK + + ++++GEI Q Y+F+R+ EVA L+ +
Sbjct: 846 QVIEDMPLDEFERHKEALAVKKLEKPKTIFQQFSQFYGEIAMQTYHFEREEAEVAILRKI 905
Query: 932 TKEDIIKFYKEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEV 991
+K D + ++K+ +A D R +SVH+++++ D P + + + +
Sbjct: 906 SKADFVDYFKKFIAKDGEERRVLSVHIVSQQTDENATSEAEPVE-------ITNMERHKP 958
Query: 992 IQNMTEFKRGLPLFPLVKPHINFMA 1016
I ++ FK L+P+ P ++ A
Sbjct: 959 ISDIVTFKSCKELYPIALPFLDIKA 983
>emb|CAO23585.1| unnamed protein product [Vitis vinifera]
Length = 965
Score = 1037 bits (2683), Expect = 0.0, Method: Composition-based stats.
Identities = 370/966 (38%), Positives = 543/966 (56%), Gaps = 16/966 (1%)
Query: 49 RIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSH 108
I K D REYR + L N ++ LLISDP TDK++A++ V +GS SDP GL+H
Sbjct: 3 EAAVEIVKPRTDTREYRRIVLRNSLEALLISDPDTDKAAASMSVSVGSFSDPEGFPGLAH 62
Query: 109 FCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQF 168
F EHMLF ++KYP E+ YS++++EH GS+NAFT+ EHTNY+FDV+ + E ALDRFAQF
Sbjct: 63 FLEHMLFYASEKYPLEDSYSKYITEHGGSTNAFTASEHTNYFFDVNTDCFEEALDRFAQF 122
Query: 169 FLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLET 228
F+ PL RE+ AVDSE++KN+++DAWR+ QL+K HP+ KF TGN+ TLE
Sbjct: 123 FVKPLMSADATTREIKAVDSENKKNLLSDAWRMDQLQKHVSAEGHPYHKFSTGNRDTLEV 182
Query: 229 RPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEF 288
+P ++G+D R EL+KF+ +YS+NLM + V +ESLD + +LV F E++NK+
Sbjct: 183 KPKEKGLDTRHELIKFYEEHYSANLMHLVVYTKESLDKIQSLVEHKFQEIQNKDRINFHI 242
Query: 289 PEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLS 348
P EHL+ L K VPIK L V +PI YK P YLGHLIGHEG GSL
Sbjct: 243 CGQPCTSEHLQILVKTVPIKQGHKLIVVWPITPSIHNYKEGPCRYLGHLIGHEGKGSLFY 302
Query: 349 ELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQE 408
LK+ GW +L +++ F FF + +DLT+ G H++DI+ +F+YI L+ G +
Sbjct: 303 ILKTLGWATSLSAWEEDWTCEFSFFEVVIDLTDAGHEHMQDIVGLLFKYISLLQQTGVCK 362
Query: 409 WVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVL 468
W+F E + F ++DK Y ++ + YP ++ L L +F PD+I+ VL
Sbjct: 363 WIFDELSAICETMFHYQDKIPSIDYVVNVSSNMELYPPKDWLVGSSLPSKFSPDVIQKVL 422
Query: 469 DKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKN 528
D+L P NVR+ SK+FEG TD E WYGT + E I +I++W A LP N
Sbjct: 423 DELAPNNVRIFWESKNFEGHTDMVEPWYGTAFSIEKITVSMIQQWMLAAPTEHLHLPDPN 482
Query: 529 EFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPL 588
+FIPT+ + ++ E +P L++ ++ S LW+K D F PKA + +F PFA P
Sbjct: 483 DFIPTDLSLKNVQ-EKAKFPVLLRKSSYSTLWYKPDTMFSTPKAYVKIDFNCPFASSSPE 541
Query: 589 HCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEK 648
+ ++ LL D LNE AY AE+AGL Y L NT G +++ GYN K ILL+ +++K
Sbjct: 542 ADVLTDIFTRLLMDYLNEDAYYAEVAGLYYCLSNTDSGFQVAMAGYNHKLRILLETVVKK 601
Query: 649 MATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVT 708
+A F++ RF +IKE + N + +QP+Q AM Y L++ + W + E + +
Sbjct: 602 IANFKVKPDRFLVIKELVTKGYQNVKFQQPYQQAMCYRSLILHDNTWPWMDGLEVIPHLE 661
Query: 709 LPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTL--IEHAHTKPLLPSQLVRY 766
L F+P LLSR +E + GNI + A ++ +ED +PL PSQ +
Sbjct: 662 ADDLAKFVPMLLSRAFLECYIAGNIEPKEAEAMIHHIEDIFYSGPRPICQPLFPSQYLTN 721
Query: 767 REVQLPDRGWFVY--QQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLR 824
R ++L + Y + N N + Y Q N+ L+LF I + F+ LR
Sbjct: 722 RVIKLDRGMSYFYPAEGLNPSDENSALVHYIQVHRDDFLPNVKLQLFALIAKQQAFHQLR 781
Query: 825 TKEQLGYIVFSGPRRANGIQGLRFIIQSE-KPPHYLESRVEAFLITMEKSIEDMTEEAFQ 883
+ EQLGYI R +GI G++F+IQS K P +++SR+E FL E + M+E+ F+
Sbjct: 782 SVEQLGYITELMLRNDSGIHGVQFMIQSTVKGPGHIDSRIEEFLKMFEFKLYAMSEDEFK 841
Query: 884 KHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEM 943
++ L +L+K K L E YW EI FDR EVA LK LT++++I F+ E
Sbjct: 842 SNVNTLVDMKLEKYKNLWEESGFYWQEIYDGTLKFDRTEAEVAALKKLTQKELIDFFNEH 901
Query: 944 LAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLP 1003
+ V AP++ +SV V S + I + I ++ +F++ P
Sbjct: 902 IKVGAPQKKTLSVRVYGCLHTSEYAEEQKEANQPIQVK----------IDDIFKFRKSQP 951
Query: 1004 LFPLVK 1009
L+ K
Sbjct: 952 LYGSFK 957
>ref|XP_681313.1| hypothetical protein AN8044.2 [Aspergillus nidulans FGSC A4]
gb|EAA59666.1| hypothetical protein AN8044.2 [Aspergillus nidulans FGSC A4]
Length = 1100
Score = 1032 bits (2668), Expect = 0.0, Method: Composition-based stats.
Identities = 379/980 (38%), Positives = 571/980 (58%), Gaps = 44/980 (4%)
Query: 42 MNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPP 101
M + +R+ + K D R YR ++L N ++ LL+ DP TDK++AA+DVH+GS SDP
Sbjct: 1 MTMRSAERLTEGLEKPSLDDRSYRVIQLPNKLEALLVHDPETDKAAAAMDVHVGSFSDPA 60
Query: 102 NIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVS------- 154
++ GL+H EHMLF+GT+KYP EN Y+Q+L+ H+GSSNA+T+G TNY+F+VS
Sbjct: 61 DLQGLAHGLEHMLFMGTEKYPVENAYNQYLASHSGSSNAYTAGTETNYFFEVSATGATGE 120
Query: 155 ----------------------HEHLEGALDRFAQFFLCPLFDESCKDREVNAVDSEHEK 192
L GALDRFAQFF+ PLF E+ DRE+ AVDSE++K
Sbjct: 121 SSGQVTPNGTTNGTSAESKSNGPSPLYGALDRFAQFFISPLFLENTLDREMQAVDSENKK 180
Query: 193 NVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQELLKFHSAYYSSN 252
N+ +D WRL QL K+ NP HP++ F TGN TL+ P + G+++R E +KF+ +YS+N
Sbjct: 181 NLQSDLWRLMQLNKSLSNPDHPYNHFSTGNLQTLKEEPQKRGVEIRNEFMKFYEKHYSAN 240
Query: 253 LMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQ-EEHLKQLYKIVPIKDIR 311
M + VLGRESLD+L V +LF+ V NK++P + P + + P+ D R
Sbjct: 241 RMKLVVLGRESLDELEKWVSELFAGVSNKDLPQNRWDGIPIWLPNDMCKQIFAKPVMDTR 300
Query: 312 NLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFM 371
++ + FP D +K Y+S P Y+ HLIGHEGPGS+L+ +K+KGW N L G G
Sbjct: 301 SVDIYFPFLDEEKLYESQPSRYISHLIGHEGPGSILAYIKAKGWANGLSAGVMPVCPGAA 360
Query: 372 FFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAVAFRFKDKERPR 431
FF ++V LT+EGL + ++ +F+YI ++ P+ W+F+E K+L V F+FK K
Sbjct: 361 FFTVSVRLTQEGLQQYQQVVKVIFEYIAMIKEREPEAWIFEEMKNLAEVEFKFKQKSPAS 420
Query: 432 GYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDR 491
+TS+++ ++ E L + LL +F P+ I+ L LR +N ++ +V++ + G D
Sbjct: 421 RFTSRLSSVMQKPLPREWLLSGSLLRKFDPEAIKKALSYLREDNFKLIVVAQDYPGDWDT 480
Query: 492 TEEWYGTQYKQEAIPDEVIKKWQNA------DLNGKFKLPTKNEFIPTNFEILPLE-KEA 544
E+WYGT+YK E +P + + + A + +P KNEF+PT + E E
Sbjct: 481 KEKWYGTEYKVEDVPKDFMSGIRAALDTTPETRLKELHMPHKNEFVPTRLSVEKKEVSEP 540
Query: 545 TPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELLKDSL 604
P LI+ +LWFK+DD+F++PKA + +P + P + + LY EL++D+L
Sbjct: 541 QKTPKLIRHDDHVRLWFKKDDRFWVPKATVFVTLRNPLVWATPANLVKSKLYCELVRDAL 600
Query: 605 NEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFEIIKE 664
EY+Y AELAGL Y L +I+G+ +SV GYNDK +LL+K+ M EI+ RF IIKE
Sbjct: 601 VEYSYDAELAGLDYHLSASIFGLDISVGGYNDKMAVLLEKVFTSMRDLEINPDRFRIIKE 660
Query: 665 AYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLH 724
RS N +QP+ Y R L E W ++ LD + +K F PQ+L + H
Sbjct: 661 RLTRSYKNAEYQQPYYQVGDYTRYLTAERGWLNEQYAAELDHIEAEDIKCFFPQILRQNH 720
Query: 725 IEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQR-- 782
IE L HGNI K+ AL + VE L +++ L SQ R V +P ++Y++
Sbjct: 721 IEVLAHGNIYKEDALRMTDTVESIL----NSRTLPQSQWYVRRNVIIPPGSDYIYERPLK 776
Query: 783 NEVHNNCGIEIYYQTDM-QSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRAN 841
+ + N IE Y L LF Q+ EP F+ LR+KEQLGY+V+SG R +
Sbjct: 777 DPANVNHCIEYYLFIGSIADEVLRAKLLLFAQMTDEPAFDQLRSKEQLGYVVWSGARYSA 836
Query: 842 GIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKLS 901
G R IIQSE+ YLESR+++FL K++E MTE+ F+ H +++ +RL+K K LS
Sbjct: 837 TTIGYRVIIQSERTAQYLESRIDSFLSNFGKTLETMTEDEFEGHKRSVINKRLEKLKNLS 896
Query: 902 AECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLAR 961
+E +++W I S+ Y+F ++ T+ A ++ LTK DI+ FYK+M+ +P R K+S+H+ A+
Sbjct: 897 SETSRFWSHIGSEDYDFQQNETDAARVRALTKSDILDFYKQMIDPASPTRGKLSIHLKAQ 956
Query: 962 EMDSCPVVGEFPCQNDINLS 981
+ E + ++
Sbjct: 957 AGAHAVELKEQKARLLSFVT 976
>ref|XP_001397499.1| hypothetical protein An16g01860 [Aspergillus niger]
emb|CAK42803.1| unnamed protein product [Aspergillus niger]
Length = 1167
Score = 1031 bits (2667), Expect = 0.0, Method: Composition-based stats.
Identities = 374/977 (38%), Positives = 575/977 (58%), Gaps = 30/977 (3%)
Query: 11 PALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPEDKREYRGLELA 70
PAL S+ +++ LP R +I+RI + K D R YR + L
Sbjct: 59 PALRSS-HALVSLSLPSRARFFSN------TATMGSIERIAEQLEKPELDDRSYRVIRLP 111
Query: 71 NGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKKYPKENEYSQF 130
N ++ LL+ DP TDK+SAA++V++G+ SD ++ G++H EH+LF+GT+KYPKEN Y+Q+
Sbjct: 112 NKLEALLVHDPDTDKASAAVNVNVGNFSDADDMPGMAHAVEHLLFMGTQKYPKENAYNQY 171
Query: 131 LSEHAGSSNAFTSGEHTNYYFDV--------SHEHLEGALDRFAQFFLCPLFDESCKDRE 182
L+ H+GSSNA+T+ TNY+F++ L GALDRFAQFF+ PLF ES DRE
Sbjct: 172 LASHSGSSNAYTAATETNYFFEIDTPAKPNYPTSPLYGALDRFAQFFVEPLFLESTLDRE 231
Query: 183 VNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQELL 242
+ AVDSE++KN+ +D WRL QL K NP HP+ F TGN TL+ P + G++VRQE +
Sbjct: 232 LRAVDSENKKNLQSDLWRLMQLNKTLSNPAHPYHHFSTGNLQTLKEEPQKRGLEVRQEFI 291
Query: 243 KFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPE-HPFQEEHLKQL 301
KF+ A+YSSN+M + VLGR+ LD++ V LF V+N+++P + P EHL +
Sbjct: 292 KFYQAHYSSNIMKLVVLGRDPLDEMEQWVGDLFKHVKNQDLPQNRWDHAQPCLPEHLGKQ 351
Query: 302 YKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLVG 361
P+ D+R+L + FP D + ++S P YL HLIGHEGPGS+L+ +K+KGW N L
Sbjct: 352 IFAKPVMDMRSLDIYFPFMDEESMFESQPSRYLSHLIGHEGPGSILAYIKAKGWANGLSA 411
Query: 362 GQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAVA 421
G G FF I+V LT EGL ++ +F+YI ++ PQ+W+F E K+L V
Sbjct: 412 GVMPVCPGSAFFTISVRLTPEGLKQYREVTKVVFEYIGMIKEREPQQWIFDEMKNLAEVE 471
Query: 422 FRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAIV 481
FRFK K +TS+++ ++ E L + LL +F P+L++ L LRP+N R+ IV
Sbjct: 472 FRFKQKSPASRFTSRLSSVMQKPYPREWLLSGSLLRKFEPELVKKALSYLRPDNFRMVIV 531
Query: 482 SKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNA------DLNGKFKLPTKNEFIPTNF 535
++ + G + E+WYGT+YK E IP + + + A + +P KNEF+PT
Sbjct: 532 AQDYPGDWNCREKWYGTEYKVEDIPQDFMDSIRKAVETSPESRLSELHMPHKNEFVPTRL 591
Query: 536 EILPLE-KEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAY 594
+ E E P LI+ +LW+K+DD+F++PKA ++ +P + P + A
Sbjct: 592 SVEKKEVSEPAKTPKLIRHDDHVRLWYKKDDRFWVPKATVHITLRNPLVWATPANLVKAK 651
Query: 595 LYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEI 654
Y EL++D+LNEY+Y AELAGL Y L +++G+ +SV GYNDK +LL+K++ M +
Sbjct: 652 FYSELVRDALNEYSYDAELAGLDYSLSASLFGLDISVGGYNDKMSVLLEKVLTSMRDLVV 711
Query: 655 DEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKA 714
RF IIKE R+ N +QP Y R L E W ++ L+ + +
Sbjct: 712 KPDRFNIIKERMTRNYKNAEYQQPFYQVGDYTRYLTAERTWLNEQYAAELEHIEAEDVSC 771
Query: 715 FIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDR 774
F PQ+L + HIE L HGN+ K+ AL + +VE TL ++ L SQ R + LP
Sbjct: 772 FFPQILRQNHIEVLAHGNLYKEDALRMTDLVESTL----QSRTLPESQWYVRRNMILPPG 827
Query: 775 GWFVYQQ--RNEVHNNCGIEIYYQTDM-QSTSENMFLELFCQIISEPCFNTLRTKEQLGY 831
++Y++ ++ + N IE Y + L LF Q+ EP F+ LR+KEQLGY
Sbjct: 828 ANYIYERTLKDPANVNHCIEYYLFIGKIDDDALRAKLLLFAQMTDEPAFDQLRSKEQLGY 887
Query: 832 IVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAI 891
+V+SG R + G R IIQSE+ YLESR+++FL KS+++M+E+ F+ H +++
Sbjct: 888 VVWSGARYSATTMGYRVIIQSERNAPYLESRIDSFLTGFGKSLQNMSEQDFENHKRSVVN 947
Query: 892 RRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRR 951
+RL+K K LS+E ++W I S+ ++F ++ ++ A ++ LT+ D+I+F+++ + + R
Sbjct: 948 KRLEKLKNLSSETNRFWSHIGSEYFDFVQNESDAANVRKLTQADLIQFFQQFVDPTSATR 1007
Query: 952 HKVSVHVLAREMDSCPV 968
K+++H+ A+
Sbjct: 1008 AKLAIHLKAQAGAHAHA 1024
>gb|ABH09708.1| STE23-like protein [Penicillium marneffei]
Length = 1038
Score = 1028 bits (2658), Expect = 0.0, Method: Composition-based stats.
Identities = 384/1032 (37%), Positives = 583/1032 (56%), Gaps = 63/1032 (6%)
Query: 42 MNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPP 101
M + I + + K D R YR ++L N ++ LL+ DP TDK+SA+ +V++G+ SD
Sbjct: 1 MTMSEVTHITDRLEKPELDDRSYRVIKLGNQLEALLVHDPDTDKASASANVNVGNFSDEE 60
Query: 102 NIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSH------ 155
+ G++H EH+LF+GT+KYPKEN Y+Q+L+ H+GSSNA+T TNY+F+V+
Sbjct: 61 AMPGMAHAVEHLLFMGTEKYPKENAYNQYLASHSGSSNAYTGAIETNYFFEVAATGESKS 120
Query: 156 ------------------------EHLEGALDRFAQFFLCPLFDESCKDREVNAVDSEHE 191
L GALDRFAQFF+ PLF ES DRE+ AVDSE++
Sbjct: 121 PESANGEKSAVSSSTTALSKDSATSPLYGALDRFAQFFIAPLFLESTLDRELRAVDSENK 180
Query: 192 KNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQELLKFHSAYYSS 251
KN+ +D WRL QL K+ NP+HP+ KF TGN TL P G++VR + ++FH +YS+
Sbjct: 181 KNLQSDVWRLMQLNKSLSNPEHPYHKFSTGNLQTLRDDPQSRGVEVRSKFIEFHKKHYSA 240
Query: 252 NLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFP-EHPFQEEHLKQLYKIVPIKDI 310
N M + VLGRESLD L + VV+LFSEV+NKN+P + P + L P+ D
Sbjct: 241 NRMKLVVLGRESLDQLESWVVELFSEVQNKNLPQNRWDDVQPLSADQLCTQVFAKPVMDS 300
Query: 311 RNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGARGF 370
R+L + FP D + Y++ P Y+ HLIGHEGPGS+LS +K+KGW N L G G
Sbjct: 301 RSLDIYFPFLDEDELYETLPSRYISHLIGHEGPGSILSYIKAKGWANGLSAGAMSVGPGS 360
Query: 371 MFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAVAFRFKDKERP 430
FF I+V LTE+GL H ++I+ +FQ+I ++ P++W++ E ++L V FRFK K
Sbjct: 361 AFFTISVRLTEDGLTHYKEIVKIIFQHIAMIKERAPEKWIYDEMQNLAEVEFRFKQKSPA 420
Query: 431 RGYTSKIAGILHYY-PLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKT 489
+TS+++ ++ P E +L+ LL +F DLI L LR +N R+ IVS+ F G
Sbjct: 421 SRFTSRLSSVMQKPLPREWLLSGNNLLRKFDADLITKALSYLRSDNFRLMIVSQHFPGDW 480
Query: 490 DRTEEWYGTQYKQEAIPDEVIKKWQNA------DLNGKFKLPTKNEFIPTNFEILPLE-K 542
D E+WYGT YK+E IP + + + +NA + +P KNEFIPT + E
Sbjct: 481 DAKEKWYGTDYKEEKIPQDFLTEIRNALASAPSERVSDLHMPHKNEFIPTRLSVEKKEVA 540
Query: 543 EATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELLKD 602
+ P P LI+ ++W+K+DD+F++PKA ++ + + P + A LY EL++D
Sbjct: 541 QPAPTPKLIRLDDHVRVWYKKDDRFWVPKATVHITLRNSLVWATPANHVKAKLYCELVRD 600
Query: 603 SLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFEII 662
+L EY+Y AELAGL Y+L +I+G+ +SV GYNDK +LL+K++ M + RF+II
Sbjct: 601 ALVEYSYDAELAGLDYNLSASIFGLDVSVGGYNDKMSVLLEKVVTTMRDLVVLPDRFKII 660
Query: 663 KEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSR 722
KE R+ N +QP+ R L E W ++ L+ + + AF PQLL +
Sbjct: 661 KERLTRAYRNAEYQQPYYQVGDMTRYLTAEKTWINEQYAAELEHIEADDVAAFFPQLLRQ 720
Query: 723 LHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQR 782
HIE L HGN+ K+ AL + +VE+ + ++ L SQ R + P ++Y+++
Sbjct: 721 NHIEVLAHGNLYKEDALKMTDIVENIM----RSRTLPQSQWHVRRNIIFPPGSNYIYERQ 776
Query: 783 NEVHN--NCGIEIYYQTDMQSTS-ENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRR 839
+ N IE Y + L L Q+ EP F+ LR+KEQLGY+V+SG R
Sbjct: 777 LKDPQNVNNCIEYYLFVGKITDEVLRAKLLLLAQMTEEPAFDQLRSKEQLGYVVWSGARY 836
Query: 840 ANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKK 899
+ G R IIQSE+ YLE R++ FL K++++MTEE F+ H +++ +RL+K K
Sbjct: 837 SATTIGYRVIIQSERTAQYLEGRIDNFLAQFAKTLDEMTEEEFESHKRSIINKRLEKLKN 896
Query: 900 LSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVL 959
L +E +++W I S+ +NF + + A ++TLTK DI+ F+++ + + R K+S+H+
Sbjct: 897 LGSETSRFWTHIGSEYFNFLQHEVDAATVRTLTKPDIVAFFRQYIDPSSETRAKISIHLN 956
Query: 960 AREMDSCPVVGEFPCQNDINLSQAPALPQ-----------------PEVIQNMTEFKRGL 1002
A+ + + + + S L P I N+ +FK L
Sbjct: 957 AQSAKTDELPVDTSETAEGAESLHNQLTNVSLSNGDVTTIKTTSRQPIYITNVPQFKARL 1016
Query: 1003 PLFPLVKPHINF 1014
P+ P P ++
Sbjct: 1017 PVSPGPSPVVDL 1028
>ref|XP_001629798.1| predicted protein [Nematostella vectensis]
gb|EDO37735.1| predicted protein [Nematostella vectensis]
Length = 947
Score = 1027 bits (2656), Expect = 0.0, Method: Composition-based stats.
Identities = 557/915 (60%), Positives = 708/915 (77%), Gaps = 16/915 (1%)
Query: 47 IKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGL 106
+K + I KSP+D R+YRGL L NG+KVLLI D +TDKS+AA+DVHIGSL+DP + GL
Sbjct: 4 VKEVHKDIPKSPQDDRDYRGLLLENGLKVLLIHDSSTDKSAAAMDVHIGSLTDPKELPGL 63
Query: 107 SHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFA 166
+HFCEHMLFLGT+KYP EN Y+QFL+E+ GSSNAFTSGEHTNY+FDV +E L ALDRFA
Sbjct: 64 AHFCEHMLFLGTEKYPGENAYTQFLTENGGSSNAFTSGEHTNYFFDVKYESLSNALDRFA 123
Query: 167 QFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTL 226
QFFLCPLF+ KDREVNAVDSE+ KN +ND WRL QL+K+T +P HP++KF TGNK TL
Sbjct: 124 QFFLCPLFNADAKDREVNAVDSENSKNRLNDMWRLNQLDKSTVDPSHPYNKFCTGNKLTL 183
Query: 227 ETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLP 286
+TRP ++GID R+ELLKFHS YYS+N+M++ V+GRESLD++T +VVKLFS V+NKNV +P
Sbjct: 184 DTRPKEKGIDTREELLKFHSLYYSANIMSLSVIGRESLDEMTEMVVKLFSPVQNKNVTIP 243
Query: 287 EFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSL 346
FPEHP+ E ++ L+K+VP+KD++NL + FPIPD+ KYY P HY+ HLIGHEG GSL
Sbjct: 244 TFPEHPYGAEQVQTLFKVVPVKDMKNLNLMFPIPDMSKYYHFKPSHYISHLIGHEGEGSL 303
Query: 347 LSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGP 406
LSELK+KGWVN LV G +GA+GFMFF+ N++LT EG H+ +I +FQY++ LR E P
Sbjct: 304 LSELKAKGWVNALVAGALDGAKGFMFFMCNMELTNEGQDHIFEISTSVFQYLEMLRREEP 363
Query: 407 QEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEM 466
EWVF+ECK L V FRF DKE PR Y +A LH + +++VL +LL FRPDLI+
Sbjct: 364 FEWVFEECKALAEVRFRFNDKETPRSYVCHLARSLHDFSIDDVLRGPHLLTSFRPDLIKQ 423
Query: 467 VLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPT 526
VLD L PE VR+ IVSK+FEGKTD+TEEWYGT+Y E I + IK W+N LN +P
Sbjct: 424 VLDNLVPEKVRITIVSKAFEGKTDKTEEWYGTEYSMERIDQQQIKDWKNVSLNAALTIPK 483
Query: 527 KNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVD 586
KNEFIPT+ +I P E D+ ++K+WFKQD F LPKAC+ FE SP AY+D
Sbjct: 484 KNEFIPTDLDIRPAPGE---------DSPLTKVWFKQDVTFLLPKACMLFEITSPLAYID 534
Query: 587 PLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKII 646
P HCNMAY++L+LLKDSLNEYAY AE+AG++Y+L NT+YG+++S++GYN KQ IL++KI+
Sbjct: 535 PCHCNMAYIFLQLLKDSLNEYAYDAEIAGVTYNLDNTMYGIFMSIRGYNHKQGILMEKIL 594
Query: 647 EKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDD 706
++M F++D RF +IKE Y + L NF+AEQPHQHA+YY L+ E+AW KDEL +AL++
Sbjct: 595 KRMTKFKVDPNRFRLIKERYEQGLRNFKAEQPHQHALYYTSYLLEELAWHKDELIDALEE 654
Query: 707 VTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRY 766
VT+ +L+AFIPQLL RLHIE LLHGN+T++ ALG++ +E E++ TKPLLP QL R+
Sbjct: 655 VTIEKLQAFIPQLLGRLHIECLLHGNVTEKEALGLVDTMESIFTENSGTKPLLPLQLRRH 714
Query: 767 REVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTK 826
RE+QLP N VH+N IEIYYQ D+Q T NM LELFCQ+I E CFN LRT+
Sbjct: 715 REIQLP-------HTVNHVHSNSSIEIYYQCDLQETRSNMLLELFCQVIHESCFNILRTQ 767
Query: 827 EQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHI 886
EQLGYIVFSGPRR NG QGLRFIIQS+K P L+SRVE FL ++ IE MT+E F+ HI
Sbjct: 768 EQLGYIVFSGPRRGNGAQGLRFIIQSDKEPSLLDSRVEVFLDKTKEMIESMTDEEFKNHI 827
Query: 887 QALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAV 946
ALA+RRLDKPKKL E K+WGEI+++QYNFDRDN EVA+L+TLTK+D++ FYK++L
Sbjct: 828 DALAVRRLDKPKKLRTETQKHWGEILTRQYNFDRDNVEVAFLRTLTKDDLLNFYKDLLEP 887
Query: 947 DAPRRHKVSVHVLAR 961
APRRHK++VH+L
Sbjct: 888 SAPRRHKLAVHILPN 902
>ref|XP_001770543.1| predicted protein [Physcomitrella patens subsp. patens]
gb|EDQ64712.1| predicted protein [Physcomitrella patens subsp. patens]
Length = 975
Score = 1027 bits (2655), Expect = 0.0, Method: Composition-based stats.
Identities = 384/972 (39%), Positives = 570/972 (58%), Gaps = 16/972 (1%)
Query: 44 NPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNI 103
+ + + K DKR+YR + L N ++ L+ISDP TDK++A++ V++GS SDP +
Sbjct: 6 SAEVVVDATDVLKPRTDKRDYRCVGLGNALQALIISDPETDKAAASMVVNVGSFSDPKGL 65
Query: 104 AGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALD 163
GL+HF EHMLF ++KYP E+ YS++L+EH G SNAFT+ EHTNY+FDVS ++LE ALD
Sbjct: 66 EGLAHFLEHMLFFSSEKYPDEDSYSKYLTEHGGHSNAFTAAEHTNYHFDVSADYLEEALD 125
Query: 164 RFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNK 223
RF+QFF+CPL RE+NAVDSE+ KN+ D WR+ QL K + HPF KFGTGN
Sbjct: 126 RFSQFFICPLLSAEATSREINAVDSENSKNLTMDMWRMNQLTKMVSSKDHPFHKFGTGNL 185
Query: 224 YTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNV 283
TL+ P G+D EL+KF+ A YS+NLM + V GRES+DDLT+LV FS ++N
Sbjct: 186 ETLDIGPKSRGVDTLDELVKFYKANYSANLMRLVVYGRESVDDLTDLVHSKFSRIKNTGR 245
Query: 284 PLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGP 343
+F P EHL+ + K VP+++ +L + FPI + Y + P YLGHLIGHE
Sbjct: 246 KAEKFTGQPCLPEHLQIIVKAVPVREGHSLEMMFPITPEIQNYMAAPSRYLGHLIGHEAD 305
Query: 344 GSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRA 403
GSL + LK GW N+L G+ + + + FF+I ++LT+ G H+E+++ FQYI+ L+
Sbjct: 306 GSLFALLKKLGWANSLSAGEIDSSLEYGFFMIAIELTDIGQDHMEEVVSLTFQYIRVLQQ 365
Query: 404 EGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDL 463
+G EW+F+E + + + F F+DK P Y + +AG + YP + L L +F +
Sbjct: 366 QGVAEWMFEEVRAVCEMKFHFQDKRPPISYVTDLAGNMLLYPPRDWLAGSSLPRQFDAEA 425
Query: 464 IEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFK 523
I ++++L+PE VR+ SK FEGKT + E WYGT Y E I + ++++W A + K
Sbjct: 426 ISGLIEQLKPERVRIFWYSKRFEGKTSQKEPWYGTDYIIERIEENLVQEWSKATTHEKLH 485
Query: 524 LPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFA 583
LP+ N FIPT+F + E +P +++ T MS+LWFK D KF PKAC+ +F P +
Sbjct: 486 LPSANVFIPTDFSLRDPE-PKVDHPFILRKTKMSRLWFKPDTKFRTPKACIQMQFNCPES 544
Query: 584 YVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLK 643
+ P + ++ +LL D LNEYAY A++AGL+Y + T G +SV GY+ K L++
Sbjct: 545 HYSPEASILTRVFTKLLVDYLNEYAYYAQVAGLNYSIVTTGTGFQVSVSGYHHKLITLVE 604
Query: 644 KIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEA 703
KI +K+ FE++E+RF +IKE M+ N R +QP+Q MY +L+ W +E E
Sbjct: 605 KICDKIVNFEVEEERFSVIKEKVMKDCMNLRFQQPYQQVMYNCSMLLEHKRWHINEFIEV 664
Query: 704 LDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHA--HTKPLLPS 761
L + L AF P++LSR+ E + GN+T A +++ +E+TL + +P S
Sbjct: 665 LPSLEARDLSAFFPRVLSRVFFECFIAGNLTSTEAESLVEQIENTLADGPLVKARPPFRS 724
Query: 762 QLVRYREVQLPDRGWFVYQQ--RNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPC 819
Q + R V+L + Y N +N ++ Y+Q +T N+ LELF
Sbjct: 725 QHIEQRIVKLGPGADWYYPIAGTNPQDDNSALQTYFQVGQDNTHINVLLELFVLAAKREV 784
Query: 820 FNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQS-EKPPHYLESRVEAFLITMEKSIEDMT 878
F+ LRT EQLGY+VF + G++G FIIQS K P LE RVE FL EK ++ M+
Sbjct: 785 FHQLRTVEQLGYVVFLMSKNDYGVRGAHFIIQSTTKDPRGLEERVEVFLEQFEKDLQKMS 844
Query: 879 EEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIK 938
+E F+K++ L +L+K K L E YWGEI F+R EVA L+ + KE+++
Sbjct: 845 DEDFKKNVDTLVEIKLEKHKNLWEESRFYWGEIEDGTLTFNRPQVEVAALRKVNKEELLD 904
Query: 939 FYKEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPAL-PQPEVIQNMTE 997
F + ++ +P R K+S+ V G+ + +I +AP I N+
Sbjct: 905 FVAQNISRKSPNRRKLSIQVYG---------GQHVAELEIAKGEAPQETTNANRIDNIYT 955
Query: 998 FKRGLPLFPLVK 1009
FKR L ++
Sbjct: 956 FKRSQQLHESLR 967
>ref|XP_001090017.1| PREDICTED: insulysin isoform 1 [Macaca mulatta]
Length = 861
Score = 1025 bits (2652), Expect = 0.0, Method: Composition-based stats.
Identities = 852/856 (99%), Positives = 855/856 (99%)
Query: 164 RFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNK 223
RFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNK
Sbjct: 6 RFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNK 65
Query: 224 YTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNV 283
YTLETRPNQEGIDVRQELLKFHS YYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENK+V
Sbjct: 66 YTLETRPNQEGIDVRQELLKFHSTYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKSV 125
Query: 284 PLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGP 343
PLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGP
Sbjct: 126 PLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGP 185
Query: 344 GSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRA 403
GSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRA
Sbjct: 186 GSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRA 245
Query: 404 EGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDL 463
EGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDL
Sbjct: 246 EGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDL 305
Query: 464 IEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFK 523
IEMVLDKLRPENVRVA+VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFK
Sbjct: 306 IEMVLDKLRPENVRVAVVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFK 365
Query: 524 LPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFA 583
LPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFA
Sbjct: 366 LPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFA 425
Query: 584 YVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLK 643
YVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLK
Sbjct: 426 YVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLK 485
Query: 644 KIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEA 703
KIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEA
Sbjct: 486 KIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEA 545
Query: 704 LDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQL 763
LDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQL
Sbjct: 546 LDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQL 605
Query: 764 VRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTL 823
VRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTL
Sbjct: 606 VRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTL 665
Query: 824 RTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQ 883
RTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQ
Sbjct: 666 RTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQ 725
Query: 884 KHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEM 943
KHIQALAIRRLDKPKKLSAECAKYWGEIISQQY+FDRDNTEVAYLKTLTKEDIIKFYKEM
Sbjct: 726 KHIQALAIRRLDKPKKLSAECAKYWGEIISQQYHFDRDNTEVAYLKTLTKEDIIKFYKEM 785
Query: 944 LAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLP 1003
LAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLP
Sbjct: 786 LAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLP 845
Query: 1004 LFPLVKPHINFMAAKL 1019
LFPLVKPHINFMAAKL
Sbjct: 846 LFPLVKPHINFMAAKL 861
>ref|XP_001146439.1| PREDICTED: insulysin isoform 1 [Pan troglodytes]
Length = 861
Score = 1025 bits (2652), Expect = 0.0, Method: Composition-based stats.
Identities = 856/856 (100%), Positives = 856/856 (100%)
Query: 164 RFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNK 223
RFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNK
Sbjct: 6 RFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNK 65
Query: 224 YTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNV 283
YTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNV
Sbjct: 66 YTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNV 125
Query: 284 PLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGP 343
PLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGP
Sbjct: 126 PLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGP 185
Query: 344 GSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRA 403
GSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRA
Sbjct: 186 GSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRA 245
Query: 404 EGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDL 463
EGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDL
Sbjct: 246 EGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDL 305
Query: 464 IEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFK 523
IEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFK
Sbjct: 306 IEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFK 365
Query: 524 LPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFA 583
LPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFA
Sbjct: 366 LPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFA 425
Query: 584 YVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLK 643
YVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLK
Sbjct: 426 YVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLK 485
Query: 644 KIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEA 703
KIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEA
Sbjct: 486 KIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEA 545
Query: 704 LDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQL 763
LDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQL
Sbjct: 546 LDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQL 605
Query: 764 VRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTL 823
VRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTL
Sbjct: 606 VRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTL 665
Query: 824 RTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQ 883
RTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQ
Sbjct: 666 RTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQ 725
Query: 884 KHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEM 943
KHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEM
Sbjct: 726 KHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEM 785
Query: 944 LAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLP 1003
LAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLP
Sbjct: 786 LAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLP 845
Query: 1004 LFPLVKPHINFMAAKL 1019
LFPLVKPHINFMAAKL
Sbjct: 846 LFPLVKPHINFMAAKL 861
>ref|NP_001060044.1| Os07g0570300 [Oryza sativa (japonica cultivar-group)]
dbj|BAC79700.1| putative insulin degrading enzyme [Oryza sativa Japonica Group]
dbj|BAF21958.1| Os07g0570300 [Oryza sativa (japonica cultivar-group)]
Length = 988
Score = 1025 bits (2650), Expect = 0.0, Method: Composition-based stats.
Identities = 373/964 (38%), Positives = 553/964 (57%), Gaps = 16/964 (1%)
Query: 51 GNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFC 110
IT+ DKR YR + L N ++ LL+SDP TDK++A+++V +G DP + GL+HF
Sbjct: 28 DVEITRPRNDKRGYRRVVLPNDLECLLVSDPDTDKAAASMNVSVGYFCDPEGLEGLAHFL 87
Query: 111 EHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFL 170
EHMLF ++KYP E+ YS++++EH GS+NAFT+ EHTN++FDV+H+ L ALDRFAQFF+
Sbjct: 88 EHMLFYASEKYPIEDSYSKYITEHGGSTNAFTTCEHTNFFFDVNHDCLNDALDRFAQFFI 147
Query: 171 CPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRP 230
PL RE+ AVDSE++KN+++D WR+ QL+ HP+ KFGTGN TLE +P
Sbjct: 148 KPLLSADATLREIKAVDSENQKNLLSDPWRMNQLQNHISLESHPYHKFGTGNWDTLEVKP 207
Query: 231 NQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPE 290
++G+D R EL+KF+ ++YS+NLM + V G+ESLD+L LV F V N FP
Sbjct: 208 KEKGLDTRLELIKFYDSHYSANLMQLVVYGKESLDNLQTLVENKFCGVRNTGRERFSFPG 267
Query: 291 HPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSEL 350
HP EHL+ L K VPIK L + +PI ++YK P Y+ HLIGHEG GSL L
Sbjct: 268 HPCSSEHLQVLVKAVPIKQGHTLRILWPITPNIRHYKEGPCKYVSHLIGHEGEGSLFYVL 327
Query: 351 KSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWV 410
K GW +L G+ + + F FF + + LT+ G H+EDI+ +F+YI L+ G +W+
Sbjct: 328 KKLGWAMSLEAGEGDWSYEFSFFSVVIKLTDVGHEHMEDIVGLLFRYITLLQTSGTLKWI 387
Query: 411 FQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDK 470
F E + + F ++DK P Y + I+ + YP E+ L A + +F PD I+ +L++
Sbjct: 388 FDELQTICETGFHYRDKGPPIHYVANISSNMQIYPPEDWLIASSVPSKFSPDAIQGILNE 447
Query: 471 LRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEF 530
L P+NVR+ SK FEG+T+ TE WYGT Y EA+P +I+KW +P N F
Sbjct: 448 LTPDNVRIFWESKKFEGQTNLTEPWYGTSYSVEAVPPSIIQKWVEKAPVEDLHMPKPNIF 507
Query: 531 IPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHC 590
+P++ + E E +P +++ T S++W+K D FF PKA + +F P + P
Sbjct: 508 LPSDLSLKNAE-EKASFPCMLRKTLFSRVWYKPDTMFFTPKAYIKMDFHCPLSRSSPESS 566
Query: 591 NMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMA 650
+ ++ LL D LN+YAY A++AGL Y ++ G +++ GYNDK LL+ +I K+A
Sbjct: 567 VLTDVFTRLLMDYLNDYAYDAQVAGLYYGVRPNDTGFQITMVGYNDKMRTLLETVIGKIA 626
Query: 651 TFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLP 710
FE+ RF +IKE + NF+ QP+Q A YY L++ E W DE A+ +
Sbjct: 627 EFEVKADRFSVIKETITKEYENFKFRQPYQQAFYYCSLILEEQTWAWDEELAAVSQIEAS 686
Query: 711 RLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHT--KPLLPSQLVRYRE 768
L+ F+P LL + IE+ GN+ A G+MQ VED L + K L SQ + R
Sbjct: 687 DLEKFLPHLLGKTFIESYFAGNMEPGAVKGVMQHVEDILFNAPVSLCKALPSSQHLTKRI 746
Query: 769 VQLPDRGWFVYQQ--RNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTK 826
V+L + Y N N + Y Q +N+ L+L + +P F+ LR+
Sbjct: 747 VKLERGLRYYYPALCLNHQDENSCLLHYIQIHQDDLKKNVILQLLALVAKQPAFHQLRSV 806
Query: 827 EQLGYIVFSGPRRANGIQGLRFIIQSE-KPPHYLESRVEAFLITMEKSIEDMTEEAFQKH 885
EQLGYI + +G++GL+FIIQS K P L++RVEAFL E ++ M + F+ +
Sbjct: 807 EQLGYITLLRQKNDSGVRGLQFIIQSTVKDPANLDARVEAFLTMFEGTLYQMPDTEFKSN 866
Query: 886 IQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLA 945
+ AL +L+K K + E A +WGEI FDR EVA L+ L KE++I+F+ +
Sbjct: 867 VNALIDMKLEKYKNIREESAFFWGEISEGTLKFDRKEVEVAALRDLKKEELIEFFNNHVK 926
Query: 946 VDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLF 1005
V+AP++ +S+ V G + + + P P I ++ F+R PL+
Sbjct: 927 VNAPQKKILSIQVYG---------GLHSSEYEKIVHDEPR-PNSYQITDIFNFRRSRPLY 976
Query: 1006 PLVK 1009
K
Sbjct: 977 GSYK 980
>emb|CAC67408.1| insulin degrading enzyme [Solanum lycopersicum]
Length = 971
Score = 1024 bits (2649), Expect = 0.0, Method: Composition-based stats.
Identities = 376/967 (38%), Positives = 548/967 (56%), Gaps = 16/967 (1%)
Query: 48 KRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLS 107
+ + I K DKR+YR + L N +++LLISDP TDK +A+++V +G+ SDP + GL+
Sbjct: 8 ENMAVEIVKPRIDKRDYRRIVLQNNLEILLISDPETDKCAASMNVCVGAFSDPEGLEGLA 67
Query: 108 HFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQ 167
HF EHMLF ++KYP E+ YS++++E+ GS+NAFTS E TNYYF+V+ + E ALDRFAQ
Sbjct: 68 HFLEHMLFYASEKYPVEDSYSKYITENGGSTNAFTSSEDTNYYFEVNADGFEEALDRFAQ 127
Query: 168 FFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLE 227
FF+ PL RE+ AVDSEH+KN+++D WR+ QL+K HP+ KF TG+ TLE
Sbjct: 128 FFIKPLMSADATTREIKAVDSEHQKNLLSDPWRMNQLQKHLSAENHPYHKFSTGSWDTLE 187
Query: 228 TRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPE 287
RP + GID RQELLKF+S YS+NLM + V ++SLD + LV F ++ N +
Sbjct: 188 VRPKERGIDTRQELLKFYSENYSANLMHLVVYSKDSLDKVEQLVRGKFQDIRNIDRNQIH 247
Query: 288 FPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLL 347
F P EHL+ L + VPIK L + +PI +YK P YLGHLIGHEG GSL
Sbjct: 248 FTGQPCIMEHLQILVRAVPIKQGHKLKIIWPITPGIHHYKEGPCRYLGHLIGHEGEGSLF 307
Query: 348 SELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQ 407
LK GW +L G+ + F FF + +DLT+ G H EDI+ +F+YI L+ G
Sbjct: 308 YVLKKLGWATSLSAGESDWTNEFSFFKVAIDLTDAGQDHFEDIMGLLFKYIHLLQQAGAS 367
Query: 408 EWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMV 467
+W+F+E + AF ++DK RP Y +A + +YP E+ L A L +F P +I+
Sbjct: 368 KWIFEELSAICETAFHYQDKIRPSDYVVNVAMNMQHYPPEDWLVASSLPSKFNPSIIQSF 427
Query: 468 LDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTK 527
L++L P+NVR+ S FEG T TE WYGT Y E + + IK+W + + LP
Sbjct: 428 LNELNPDNVRIFWESTKFEGNTSMTEPWYGTAYSIEKVGGDSIKQWMEHAPSEELHLPAP 487
Query: 528 NEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDP 587
N FIPT+ + P+ E T P L++ + S+LW+K D F PKA + +F P+ P
Sbjct: 488 NVFIPTDLSLKPV-FEKTKVPILLRKSPYSRLWYKPDTAFSSPKAYVMIDFSCPYCGHSP 546
Query: 588 LHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIE 647
+ ++ LL D LNEYAY A++AGL YD+ T G L++ GYNDK +LL+ +IE
Sbjct: 547 EAEVLTEIFTRLLMDYLNEYAYNAQVAGLYYDISKTNSGFQLTLFGYNDKLRVLLEAVIE 606
Query: 648 KMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDV 707
K+A FE+ RF ++KE + NF+ +QP+Q MYY LL+ + W +E + L +
Sbjct: 607 KVAKFEVKPDRFSVVKELVTKQYQNFKFQQPYQQVMYYCSLLLKDNIWPWNEELDVLPHL 666
Query: 708 TLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAH--TKPLLPSQLVR 765
+ L F P L++R +E + GN+ + A ++Q++ED + +KPL SQ +
Sbjct: 667 KVDDLVKFYPLLMARSFMECYVAGNVEQAEAESMIQLIEDVFFKGPQSISKPLFASQHLT 726
Query: 766 YREVQLPDRGWFVY--QQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTL 823
R V L +VY + N N + Y Q N+ L+LF I +P F+ L
Sbjct: 727 NRVVNLERGVNYVYAAEGLNPSDENSALVHYIQVHQDDFMLNVKLQLFALIAKQPAFHQL 786
Query: 824 RTKEQLGYIVFSGPRRANGIQGLRFIIQS-EKPPHYLESRVEAFLITMEKSIEDMTEEAF 882
R+ EQLGYI R +G+ G++FI+QS K P Y+++RVE F+ E + +MT + F
Sbjct: 787 RSVEQLGYITVLMQRSDSGVHGVQFIVQSTAKDPKYIDTRVELFMKMFESKLYEMTSDEF 846
Query: 883 QKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKE 942
+ ++ AL +L+K K L E YW EI FDR + E+ LK LT++++ F+ E
Sbjct: 847 KNNVNALIDMKLEKHKNLREESRFYWREISDGTLKFDRRDREIVALKQLTQKELTDFFDE 906
Query: 943 MLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGL 1002
+ V PR+ +SV V S P I+ + F+R
Sbjct: 907 YIKVGVPRKKALSVRVYGSSHSSQ----------FQAHKNEQMEPNAVQIEEIFSFRRSR 956
Query: 1003 PLFPLVK 1009
PL+ K
Sbjct: 957 PLYSSFK 963
>ref|XP_001674236.1| Hypothetical protein CBG09322 [Caenorhabditis briggsae AF16]
emb|CAP29245.1| Hypothetical protein CBG09322 [Caenorhabditis briggsae]
Length = 994
Score = 1023 bits (2646), Expect = 0.0, Method: Composition-based stats.
Identities = 406/982 (41%), Positives = 615/982 (62%), Gaps = 12/982 (1%)
Query: 39 YSKMNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLS 98
++ + + + I K +D REYRGLEL NG+++LL+SDP+TDKS+AALDV +G L
Sbjct: 1 MTEAGKNIVLKRHDLIVKGAQDVREYRGLELTNGLRILLVSDPSTDKSAAALDVKVGHLM 60
Query: 99 DPPNIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHL 158
DP + GL+HFCEHMLFLGT KYP ENEYS+FLS HAG+SNA+T+ +HTNY+FDV + L
Sbjct: 61 DPWELPGLAHFCEHMLFLGTAKYPSENEYSKFLSAHAGNSNAYTATDHTNYHFDVKPDQL 120
Query: 159 EGALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKF 218
GALDRF QFFL P F ES +REV AVDSEH N+ ND+WR Q++++ P H + KF
Sbjct: 121 SGALDRFVQFFLSPQFTESATEREVCAVDSEHSNNLNNDSWRFLQVDRSRSKPGHDYGKF 180
Query: 219 GTGNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKL-FSE 277
GTGNK TL ++GI+ R LL+FH +YSS++M+ C++G+ESLD L + + F
Sbjct: 181 GTGNKQTLLEDARKKGIEPRDALLQFHKKWYSSDIMSCCIIGKESLDVLESYLGTYEFDA 240
Query: 278 VENKNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHL 337
+ENK V + + P+ E L + ++VPIKD R L ++FP PDL Y S PGHY+ HL
Sbjct: 241 IENKKVTRQVWKDFPYGPEQLGKKVEVVPIKDTRMLSISFPFPDLNTEYNSQPGHYISHL 300
Query: 338 IGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQY 397
IGHEGPGSLLSELK +GWV++L A GF +++ +DL+ +GL HV++II MF Y
Sbjct: 301 IGHEGPGSLLSELKRRGWVSSLQSDSHTQASGFGVYMVTMDLSTDGLDHVDEIIQLMFNY 360
Query: 398 IQKLRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLE 457
I L+ GP++W+ +E +L+AV FRFKDKE+P +A L Y P E++L+++YLL
Sbjct: 361 IGMLQTAGPKQWIHEELAELSAVKFRFKDKEQPMSMAINVASSLQYIPFEDILSSKYLLT 420
Query: 458 EFRPDLIEMVLDKLRPENVRVAIVSKSFEGKT-DRTEEWYGTQYKQEAIPDEVIKKWQNA 516
++ P+ I+ +LD L+PEN+ V +VS++F+G+ + TE YGT++K I E ++K++NA
Sbjct: 421 KYDPERIKQLLDTLKPENMYVRVVSQTFKGQEGNTTEPVYGTEFKMADIDKETMQKYENA 480
Query: 517 --DLNGKFKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACL 574
+ LP KNE+I T F+ P E +P LI D + S++WFKQDD++ +PK
Sbjct: 481 LKTSHHALHLPEKNEYIATKFDQKPRETIKNEHPRLIVDDSWSRVWFKQDDEYNMPKQET 540
Query: 575 NFEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGY 634
F SP DP ++ L+L L D+L E Y A+LAGL L+++ +G+ + V GY
Sbjct: 541 KFGLTSPVVSQDPRSSLLSSLWLWCLSDTLAEETYNADLAGLKCQLESSPFGVQMRVYGY 600
Query: 635 NDKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVA 694
++KQ + K + ++MA F+ID+ RF+++ E+ R+L N QP+ + +Y +L++ +
Sbjct: 601 DEKQSLFTKHLTKRMANFKIDKTRFDVLFESLKRALTNHAFSQPYSLSQHYNQLIVLDKV 660
Query: 695 WTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIE-HA 753
W+K++L ++VTL ++ F ++ + H+E L+HGN T++ A+ + + + D L
Sbjct: 661 WSKEQLLAVCENVTLEDVQNFSKEMFAAFHLELLVHGNSTEKEAIELSKELVDILKGVSP 720
Query: 754 HTKPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQ 813
+++PL ++ RE+QL + +VY+ + H+ +E+ YQ +Q+T +N + L Q
Sbjct: 721 NSRPLYRNEHCPRREMQLNNGDEYVYRHLQKTHDVGCVEVSYQVGVQNTYDNALVGLIDQ 780
Query: 814 IISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKS 873
+I EP FNTLRT E LGYIV++G R G L I+Q K ++ R+E FL T+ K
Sbjct: 781 LIREPAFNTLRTNEALGYIVWTGSRLNCGTVSLNVIVQGPKSVDHVLERIEVFLETVRKE 840
Query: 874 IEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTK 933
I++M +E F + + R +KPK LS ++W EI +QY+F EV LK++ K
Sbjct: 841 IDEMPQEEFDNQVSGMIARLEEKPKTLSGRFRRFWNEIECRQYDFAHREEEVKVLKSIKK 900
Query: 934 EDIIKFYKEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQ 993
ED++ Y + + DAP R K++V V + D V G I A A + + ++
Sbjct: 901 EDVLALYDKKIRKDAPERRKLAVFVHGKGEDREKVDG-------IVKKNAEAGKKEKEVE 953
Query: 994 NMTEFKRGLPLFPLVKPHINFM 1015
+ + ++ LPL+ P IN
Sbjct: 954 YVDQLRQFLPLYGRPIPAINLK 975
>ref|XP_532578.2| PREDICTED: similar to nardilysin (N-arginine dibasic convertase)
isoform 1 [Canis familiaris]
Length = 1227
Score = 1021 bits (2640), Expect = 0.0, Method: Composition-based stats.
Identities = 324/1000 (32%), Positives = 522/1000 (52%), Gaps = 29/1000 (2%)
Query: 34 FQKKTYSKMNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVH 93
+ K TY+KM++ + N + R LA + + T S+AAL V
Sbjct: 236 WFKSTYTKMSSTLLVETRNLNGVVGAESRSAPVQHLAGWQEEEQQGETDTVLSAAALCVG 295
Query: 94 IGSLSDPPNIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDV 153
+GS +DP ++ GL+HF EHM+F+G+ KYP EN + FL +H GS NA T E T + FDV
Sbjct: 296 VGSFADPDDLPGLAHFLEHMVFMGSLKYPDENGFDAFLKKHGGSDNASTDCERTVFQFDV 355
Query: 154 SHEHLEGALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKH 213
++ + ALDR+AQFF+ PL DREV AVDSE++ +DA R L + P H
Sbjct: 356 QRKYFKEALDRWAQFFIHPLMIRDAIDREVEAVDSEYQLARPSDANRKEMLFGSLARPGH 415
Query: 214 PFSKFGTGNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVK 273
P KF GN TL+ P + ID L +F YYS++ M + V +E+LD L V +
Sbjct: 416 PMGKFFWGNAETLKHEPKRNNIDTHARLREFWMRYYSAHYMTLVVQSKETLDTLEKWVTE 475
Query: 274 LFSEVENKNVPLPEFPE--HPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPG 331
+FS++ N +P P F PF +LY++VPI+ I L +T+ +P Q++Y+ P
Sbjct: 476 IFSQIPNNGLPKPNFGHLTDPFDTPAFNKLYRVVPIRKIHALTITWALPPQQQHYRVKPL 535
Query: 332 HYLGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGA----RGFMFFIINVDLTEEGLLHV 387
HY+ L+GHEG GS+LS L+ K W L GG E + F I++ LT+EG H
Sbjct: 536 HYISWLVGHEGKGSILSYLRKKCWALALFGGNGETGFEQNSTYSVFSISITLTDEGYEHF 595
Query: 388 EDIILHMFQYIQKLRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLE 447
++ +FQY++ L+ GP++ +F+E + + F ++++ P Y + + YPL+
Sbjct: 596 YEVAHTVFQYLKMLQKLGPEKRIFEEIQKIEDNEFHYQEQTDPVEYVENMCENMQLYPLQ 655
Query: 448 EVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPD 507
+ LT + LL E++P++I L++L P+ + ++S + EGK D E+W+GTQY E + +
Sbjct: 656 DFLTGDQLLFEYKPEVIAEALNQLVPQKANLVLLSGANEGKCDLKEKWFGTQYSMEDVEN 715
Query: 508 EVIKKWQ-NADLNGKFKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDK 566
+ W+ N +LN LP +N++I T+F + + T YP I +T LW+K+D+K
Sbjct: 716 SWAELWKTNFELNPDLHLPAENKYIATDFMLKAFDCPETEYPVKIVNTPQGCLWYKKDNK 775
Query: 567 FFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYG 626
F +PKA + F SP + + +++ +L +L E AY A++A L Y L +G
Sbjct: 776 FKIPKAYIRFHLISPLIQKSAANVVLFDIFVNILTHNLAEPAYEADVAQLEYKLVAGEHG 835
Query: 627 MYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYL 686
+ + VKG+N K P+L + II+ +A F F +I E ++ N +P A
Sbjct: 836 LIIRVKGFNHKLPLLFQLIIDYLAEFSSTPAVFTMITEQLKKTYFNILI-KPETLAKDVR 894
Query: 687 RLLMTEVAWTKDELKEAL-DDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMV 745
L++ W+ + AL D ++L L +F+ + S+L +E L+ GN+T ++ ++ V
Sbjct: 895 LLILEYARWSMIDKYRALMDGLSLESLLSFVKEFKSQLFVEGLVQGNVTSTESMDFLKYV 954
Query: 746 EDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFV-YQQRNEVHNNCGIEIYYQTDMQSTSE 804
D L + PL V+++ V+LP + N+ N + +YYQ+ +S E
Sbjct: 955 VDKL----NFMPLEQEMPVQFQVVELPGGHHLCKVRALNKGDANSEVTVYYQSGTRSLKE 1010
Query: 805 NMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEK---PPHYLES 861
+EL + EPCF+ LRTK+ LGY V+ R +GI G + ++ ++
Sbjct: 1011 YTLMELLVMHMEEPCFDFLRTKQTLGYHVYPTCRNTSGILGFSVTVGTQATKYNSEIVDK 1070
Query: 862 RVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRD 921
++E FL + E+ IE++TE+AF + AL + + L E + W E+++QQY FDR
Sbjct: 1071 KIEEFLSSFEEKIENLTEDAFNTQVTALIKLKECEDTHLGEEVDRNWNEVVTQQYLFDRL 1130
Query: 922 NTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA-----REMDSCPVVGEFPCQN 976
E+ LK+ +K D++ ++K P +SVHV+ E D P E
Sbjct: 1131 AHEIEALKSFSKSDLVSWFKAH---RGPGSKMLSVHVVGFGKYEPEEDGSPSGEESHSCE 1187
Query: 977 DINLSQAPALP----QPEVIQNMTEFKRGLPLFPLVKPHI 1012
+ L+ P P I ++ F L L P K
Sbjct: 1188 VMQLTYLPTSPLLVGSTIPITDIRAFTSTLSLLPYHKIVK 1227
Score = 45.2 bits (106), Expect = 0.029, Method: Composition-based stats.
Identities = 15/30 (50%), Positives = 21/30 (70%)
Query: 51 GNHITKSPEDKREYRGLELANGIKVLLISD 80
I KSP D ++YR ++L NG++ LLISD
Sbjct: 101 DPEIVKSPSDPKQYRYIKLRNGLQALLISD 130
>emb|CAM16904.1| nardilysin, N-arginine dibasic convertase, NRD convertase 1 [Mus
musculus]
Length = 1229
Score = 1021 bits (2640), Expect = 0.0, Method: Composition-based stats.
Identities = 326/1000 (32%), Positives = 522/1000 (52%), Gaps = 29/1000 (2%)
Query: 34 FQKKTYSKMNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVH 93
+ K +YSKM++ + N + R LA + T S+AAL V
Sbjct: 238 WFKSSYSKMSSTLLVETRNLYGVVGAESRSAPVEHLAGWQVEEQQGETDTVLSAAALCVG 297
Query: 94 IGSLSDPPNIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDV 153
+GS +DP ++ GL+HF EHM+F+G+ KYP EN + FL +H GS NA T E T + FDV
Sbjct: 298 VGSFADPDDLPGLAHFLEHMVFMGSLKYPDENGFDAFLKKHGGSDNASTDCERTVFQFDV 357
Query: 154 SHEHLEGALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKH 213
++ + ALDR+AQFF+ PL DREV AVDSE++ +DA R L + P H
Sbjct: 358 QRKYFKEALDRWAQFFIHPLMIRDAIDREVEAVDSEYQLARPSDANRKEMLFGSLARPGH 417
Query: 214 PFSKFGTGNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVK 273
P KF GN TL+ P + ID L +F YYS++ M + V +E+LD L V +
Sbjct: 418 PMGKFFWGNAETLKHEPKKNNIDTHARLREFWMRYYSAHYMTLVVQSKETLDTLEKWVTE 477
Query: 274 LFSEVENKNVPLPEFPE--HPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPG 331
+FS++ N +P P F PF +LY++VPI+ I L +T+ +P Q++Y+ P
Sbjct: 478 IFSQIPNNGLPKPNFSHLTDPFDTPAFNKLYRVVPIRKIHALTITWALPPQQQHYRVKPL 537
Query: 332 HYLGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGA----RGFMFFIINVDLTEEGLLHV 387
HY+ L+GHEG GS+LS L+ K W L GG E + F I++ LT+EG H
Sbjct: 538 HYISWLVGHEGKGSILSYLRKKCWALALFGGNGETGFEQNSTYSVFSISITLTDEGYEHF 597
Query: 388 EDIILHMFQYIQKLRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLE 447
++ +FQY++ L+ GP++ VF+E + + F ++++ P Y + + YP +
Sbjct: 598 YEVAHTVFQYLKMLQKLGPEKRVFEEIQKIEDNEFHYQEQTDPVEYVENMCENMQLYPRQ 657
Query: 448 EVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPD 507
+ LT + LL E++P++I L++L P+ + ++S + EG+ D E+W+GTQY E I +
Sbjct: 658 DFLTGDQLLFEYKPEVIAEALNQLVPQKANLVLLSGANEGRCDLKEKWFGTQYSIEDIEN 717
Query: 508 EVIKKWQ-NADLNGKFKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDK 566
+ W+ N DLN LP +N++I T+F + + T YPA I +TA LW+K+D+K
Sbjct: 718 SWTELWKSNFDLNPDLHLPAENKYIATDFTLKAFDCPETEYPAKIVNTAQGCLWYKKDNK 777
Query: 567 FFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYG 626
F +PKA + F SP + + +++ +L +L E AY A++A L Y L +G
Sbjct: 778 FKIPKAYIRFHLISPLIQKSAANVVLFDIFVNILTHNLAEPAYEADVAQLEYKLVAGEHG 837
Query: 627 MYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYL 686
+ + VKG+N K P+L + II+ + F F +I E ++ N +P A
Sbjct: 838 LIIRVKGFNHKLPLLFQLIIDYLTEFSSTPAVFTMITEQLKKTYFNILI-KPETLAKDVR 896
Query: 687 RLLMTEVAWTKDELKEAL-DDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMV 745
L++ W+ + +AL D ++L L F+ S+L +E L+ GN+T ++ ++ V
Sbjct: 897 LLILEYSRWSMIDKYQALMDGLSLDSLLNFVKDFKSQLFVEGLVQGNVTSTESMDFLKYV 956
Query: 746 EDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFV-YQQRNEVHNNCGIEIYYQTDMQSTSE 804
D L + PL V+++ V+LP + N+ N + +YYQ+ +S E
Sbjct: 957 VDKL----NFAPLEREMPVQFQVVELPSGHHLCKVRALNKGDANSEVTVYYQSGTRSLRE 1012
Query: 805 NMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEK---PPHYLES 861
+EL + EPCF+ LRTK+ LGY V+ R +GI G + ++ ++
Sbjct: 1013 YTLMELLVMHMEEPCFDFLRTKQTLGYHVYPTCRNTSGILGFSVTVGTQATKYNSETVDK 1072
Query: 862 RVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRD 921
++E FL + E+ IE++TE+AF + AL + + L E + W E+++QQY FDR
Sbjct: 1073 KIEEFLSSFEEKIENLTEDAFNTQVTALIKLKECEDTHLGEEVDRNWNEVVTQQYLFDRL 1132
Query: 922 NTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLAR-----EMDSCPVVGEFPCQN 976
E+ LK+ +K D++ ++K P +SVHV+ E D P + +
Sbjct: 1133 AHEIEALKSFSKSDLVSWFKAH---RGPGSKMLSVHVVGYGKYELEEDGAPFGEDSNSRE 1189
Query: 977 DINLSQAPALP----QPEVIQNMTEFKRGLPLFPLVKPHI 1012
+ L+ P P I ++ F L LFP K
Sbjct: 1190 GMQLTYLPPSPVLAESTTPITDIRAFTATLSLFPYHKIVK 1229
Score = 46.4 bits (109), Expect = 0.013, Method: Composition-based stats.
Identities = 15/30 (50%), Positives = 21/30 (70%)
Query: 51 GNHITKSPEDKREYRGLELANGIKVLLISD 80
I KSP D ++YR ++L NG++ LLISD
Sbjct: 97 DPEIIKSPSDPKQYRYIKLQNGLQALLISD 126
>ref|XP_001354132.1| GA18943-PA [Drosophila pseudoobscura]
gb|EAL29871.1| GA18943-PA [Drosophila pseudoobscura]
Length = 1055
Score = 1020 bits (2638), Expect = 0.0, Method: Composition-based stats.
Identities = 449/987 (45%), Positives = 656/987 (66%), Gaps = 27/987 (2%)
Query: 52 NHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCE 111
N+I KS +D R+YRGL+L NG+KVLLISDP TD S+AAL V +G +SDP N+ GL+HFCE
Sbjct: 67 NNIEKSQQDTRDYRGLQLENGLKVLLISDPNTDVSAAALSVQVGHMSDPQNLPGLAHFCE 126
Query: 112 HMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLC 171
HMLFLGT+KYP EN Y+ +LS+ GSSNA T T Y+F V+ + L+GALDRFAQFF+
Sbjct: 127 HMLFLGTEKYPHENGYTTYLSQSGGSSNAATYPLMTKYHFHVAPDKLDGALDRFAQFFIA 186
Query: 172 PLFDESCKDREVNAVD---------------------SEHEKNVMNDAWRLFQLEKATGN 210
PLF S +RE+NAV+ SEHEKN+ +D WR+ Q+ +
Sbjct: 187 PLFTPSATEREINAVNTQLHPRFTQIWALTKNSLQVNSEHEKNLPSDLWRIKQVHRHLAK 246
Query: 211 PKHPFSKFGTGNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNL 270
P H +SKFG+GNK TL P IDVR+ELLKFH +YS+N+M + V+G+ESL++L ++
Sbjct: 247 PDHAYSKFGSGNKTTLSEIPKSMNIDVREELLKFHKEWYSANIMCLAVIGKESLNELESM 306
Query: 271 VVKLFSEVENKNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNP 330
V++ FSE+ENK+V +PE+P HP+ E+ Q KIVPIKD+R+L ++F DL K+YKS P
Sbjct: 307 VMEKFSEIENKSVAVPEWPRHPYGEDRYGQKVKIVPIKDVRSLTISFTTDDLTKFYKSGP 366
Query: 331 GHYLGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDI 390
+YL HLIGHEG GS+LSEL+ GW N L+ G + GF FF I VDLT+EGL HV+DI
Sbjct: 367 DNYLTHLIGHEGKGSILSELRRLGWCNDLMAGHQNTQNGFGFFDIVVDLTQEGLEHVDDI 426
Query: 391 ILHMFQYIQKLRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVL 450
+ +FQY++ LR EGP++W+F EC LN + FRFK+KE+P + + +PLEEVL
Sbjct: 427 VNIIFQYLRMLREEGPKKWIFDECVKLNEMRFRFKEKEQPENLVTHAVSSMQIFPLEEVL 486
Query: 451 TAEYLLEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVI 510
A YL E+RPDLI +LD+LRP R+ IVS+SFE D+ E +Y T+Y E IP +++
Sbjct: 487 IAPYLSNEWRPDLISGLLDELRPSKSRIVIVSQSFEPTCDQAEPYYKTKYGLERIPTDIV 546
Query: 511 KKWQNADLNGKFKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLP 570
+ W+ DLN KL N FIPTNF+I + + +P +I DT + ++W KQD++F P
Sbjct: 547 QSWEKCDLNENLKLSLPNSFIPTNFDIADVPSDGPKHPTIILDTPILRVWHKQDNQFNKP 606
Query: 571 KACLNFEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLS 630
KAC+ F+ +P A +DPL+CN+ ++ + LLKD LNEY Y AELA L ++ G+ +
Sbjct: 607 KACMRFDMSNPLASLDPLNCNLNHMMVMLLKDQLNEYLYDAELANLKLNVVGKSGGIDFT 666
Query: 631 VKGYNDKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLM 690
+ G++DKQ +LL+K+++ + F +DEKRF+I+KE Y+RSL NF+AEQP+QH++YYL LL+
Sbjct: 667 IHGFSDKQVVLLEKLLDHLFDFRVDEKRFDILKEEYVRSLKNFKAEQPYQHSIYYLALLL 726
Query: 691 TEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTL- 749
TE AW EL +A++ VT R+ F + RLH E + GN+TKQ A + V L
Sbjct: 727 TENAWANVELLDAMELVTYDRVNNFAKEFFQRLHTECFIFGNVTKQHATEVAGRVNTRLE 786
Query: 750 IEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLE 809
+A P+L Q+++ RE +L +++++ NE H + ++Y Q Q+ N+ +
Sbjct: 787 ATNASKLPILARQMLKKREYKLLAGDSYLFEKENEYHKSSCTQLYLQCGAQTDHTNIMVN 846
Query: 810 LFCQIISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLIT 869
L Q++SEPC++ LRTKEQLGYIVFSG R+ NG G+R I+QS K P ++E R+E FL T
Sbjct: 847 LVSQVLSEPCYDCLRTKEQLGYIVFSGVRKVNGANGIRIIVQSAKHPTFVEDRIENFLQT 906
Query: 870 MEKSIEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLK 929
++IEDM + F++H +ALA+++L+KPK + + +++GEI Q Y+F+R+ EVA L+
Sbjct: 907 YLQAIEDMPLDEFERHKEALAVKKLEKPKTIFQQFIQFYGEIAMQTYHFEREEAEVAILR 966
Query: 930 TLTKEDIIKFYKEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQP 989
++K D + ++K+ +A D R +SVH+++++ D V E + + ++ + +
Sbjct: 967 KISKSDFVDYFKKFIAKDGGERRVLSVHIVSKQTDEN--VSEPKEEEPLEITN---MERH 1021
Query: 990 EVIQNMTEFKRGLPLFPLVKPHINFMA 1016
+ I ++ FK L+P+ P ++ A
Sbjct: 1022 KCISDIVAFKSCKELYPIALPFLDIKA 1048
Database: All non-redundant GenBank CDS
translations+PDB+SwissProt+PIR+PRF excluding environmental samples
from WGS projects
Posted date: May 23, 2008 5:56 PM
Number of letters in database: 883,778,997
Number of sequences in database: 2,617,685
Database: /host/Blast/data/nr_perl/nr.01
Posted date: May 23, 2008 5:54 PM
Number of letters in database: 976,759,346
Number of sequences in database: 2,761,413
Database: /host/Blast/data/nr_perl/nr.02
Posted date: May 23, 2008 5:48 PM
Number of letters in database: 374,670,760
Number of sequences in database: 1,165,270
Database: /host/Blast/data/nr_perl/nr.03
Posted date: Apr 28, 2009 5:40 PM
Number of letters in database: 114,943,120
Number of sequences in database: 354,819
Lambda K H
0.313 0.155 0.399
Lambda K H
0.267 0.0472 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,763,716,550
Number of Sequences: 6899187
Number of extensions: 618156308
Number of successful extensions: 1948932
Number of sequences better than 10.0: 300
Number of HSP's better than 10.0 without gapping: 6995
Number of HSP's successfully gapped in prelim test: 4476
Number of HSP's that attempted gapping in prelim test: 1897179
Number of HSP's gapped (non-prelim): 25154
length of query: 1019
length of database: 2,350,152,223
effective HSP length: 145
effective length of query: 874
effective length of database: 1,349,770,108
effective search space: 1179699074392
effective search space used: 1179699074392
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.2 bits)
S2: 85 (37.1 bits)