BLASTP 2.2.17 [Aug-26-2007]
Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Reference for composition-based statistics:
Schäffer, Alejandro A., L. Aravind, Thomas L. Madden,
Schaffer, Alejandro A., L. Aravind, Thomas L. Madden,
Sergei Shavirin, John L. Spouge, Yuri I. Wolf,
Eugene V. Koonin, and Stephen F. Altschul (2001),
"Improving the accuracy of PSI-BLAST protein database searches with
composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005.
Query= XP_825204__[Trypanosoma_brucei]
(437 letters)
Database: All non-redundant GenBank CDS
translations+PDB+SwissProt+PIR+PRF excluding environmental samples
from WGS projects
6,899,187 sequences; 2,350,152,223 total letters
Searching..................................................done
Results from round 1
Score E
Sequences producing significant alignments: (bits) Value
ref|XP_847200.1| isocitrate dehydrogenase [NADP], mitochond... 909 0.0
ref|XP_813368.1| isocitrate dehydrogenase [NADP], mitochond... 751 0.0
gb|ABF20272.1| mitochondrial isocitrate dehydrogenase [Leis... 705 0.0
ref|XP_001463680.1| isocitrate dehydrogenase [NADP], mitoch... 700 0.0
gb|ABF20244.1| mitochondrial isocitrate dehydrogenase [Leis... 700 0.0
ref|XP_001681361.1| isocitrate dehydrogenase [NADP], mitoch... 699 0.0
gb|ABF20271.1| mitochondrial isocitrate dehydrogenase [Leis... 693 0.0
ref|XP_001562802.1| isocitrate dehydrogenase [NADP], mitoch... 687 0.0
ref|XP_001698704.1| isocitrate dehydrogenase, NADP-dependen... 598 e-169
ref|NP_786984.1| isocitrate dehydrogenase 2 (NADP+), mitoch... 574 e-162
ref|NP_766599.1| isocitrate dehydrogenase 2 (NADP+), mitoch... 574 e-162
pdb|1LWD|A Chain A, Crystal Structure Of Nadp-Dependent Iso... 573 e-162
sp|Q04467|IDHP_BOVIN Isocitrate dehydrogenase [NADP], mitoc... 573 e-162
sp|P54071|IDHP_MOUSE Isocitrate dehydrogenase [NADP], mitoc... 573 e-161
sp|P33198|IDHP_PIG Isocitrate dehydrogenase [NADP], mitocho... 573 e-161
ref|NP_001026770.1| hypothetical protein LOC431056 [Gallus ... 572 e-161
ref|XP_001369305.1| PREDICTED: hypothetical protein [Monode... 572 e-161
ref|NP_001014183.1| isocitrate dehydrogenase 2 (NADP+), mit... 571 e-161
gb|ACO14046.1| Isocitrate dehydrogenase, mitochondrial prec... 571 e-161
gb|EAX02083.1| isocitrate dehydrogenase 2 (NADP+), mitochon... 570 e-161
ref|XP_001168316.1| PREDICTED: isocitrate dehydrogenase 2 (... 569 e-160
ref|XP_001095686.1| PREDICTED: isocitrate dehydrogenase 2 (... 567 e-160
ref|XP_510589.2| PREDICTED: isocitrate dehydrogenase 2 (NAD... 567 e-160
ref|XP_536192.2| PREDICTED: similar to isocitrate dehydroge... 567 e-160
ref|NP_002159.2| isocitrate dehydrogenase 2 (NADP+), mitoch... 567 e-160
emb|CAA49208.1| isocitrate dehydrogenase (NADP+) [Homo sapi... 567 e-159
ref|NP_001004799.1| MGC69505 protein [Xenopus tropicalis] >... 566 e-159
gb|ABE98244.1| mitochondrial isocitrate dehydrogenase 2-lik... 565 e-159
dbj|BAD96636.1| isocitrate dehydrogenase 2 (NADP+), mitocho... 565 e-159
ref|NP_955858.1| isocitrate dehydrogenase 2 (NADP+), mitoch... 565 e-159
ref|XP_821599.1| isocitrate dehydrogenase, putative [Trypan... 565 e-159
gb|ABO93633.1| isocitrate dehydrogenase 2 [Toxoplasma gondii] 564 e-159
emb|CAG02362.1| unnamed protein product [Tetraodon nigrovir... 564 e-159
gb|AAC52473.1| isocitrate dehydrogenase 561 e-158
prf||2211361A isocitrate dehydrogenase 561 e-158
emb|CAG13105.1| unnamed protein product [Tetraodon nigrovir... 561 e-158
ref|XP_001778805.1| predicted protein [Physcomitrella paten... 560 e-158
ref|ZP_01885694.1| isocitrate dehydrogenase [Pedobacter sp.... 560 e-157
ref|NP_970434.1| isocitrate dehydrogenase [Bdellovibrio bac... 560 e-157
ref|XP_001426548.1| hypothetical protein GSPATT00029781001 ... 559 e-157
ref|NP_001080321.1| hypothetical protein LOC380013 [Xenopus... 559 e-157
ref|NP_010217.1| Mitochondrial NADP-specific isocitrate deh... 559 e-157
ref|XP_001608101.1| PREDICTED: similar to isocitrate dehydr... 559 e-157
ref|XP_001457045.1| hypothetical protein GSPATT00022820001 ... 558 e-157
gb|ACO14957.1| Isocitrate dehydrogenase cytoplasmic [Caligu... 558 e-157
ref|NP_509875.1| C34F6.8 [Caenorhabditis elegans] >gi|38747... 558 e-157
ref|XP_001688948.1| AGAP006660-PA [Anopheles gambiae str. P... 558 e-157
ref|XP_001778590.1| predicted protein [Physcomitrella paten... 557 e-157
ref|NP_001043749.1| Os01g0654500 [Oryza sativa (japonica cu... 557 e-157
gb|AAC64182.1| NADP-dependent isocitrate dehydrogenase [Gly... 557 e-157
gb|AAL11503.1|AF367443_1 NADP-dependent isocitrate dehydrog... 556 e-157
ref|ZP_00952302.1| isocitrate dehydrogenase [Oceanicaulis a... 556 e-157
ref|XP_001676039.1| Hypothetical protein CBG17397 [Caenorha... 556 e-156
ref|XP_001633903.1| predicted protein [Nematostella vectens... 556 e-156
gb|AAR05796.1| NADP+-isocitrate dehydrogenase [Pinus pinaster] 556 e-156
ref|XP_451683.1| unnamed protein product [Kluyveromyces lac... 555 e-156
ref|XP_780121.1| PREDICTED: similar to cytosolic NADP-depen... 555 e-156
dbj|BAC77065.1| NADP-specific isocitrate dehydrogenase [Lup... 555 e-156
ref|XP_860821.1| PREDICTED: similar to Isocitrate dehydroge... 555 e-156
ref|XP_001168291.1| PREDICTED: isocitrate dehydrogenase 2 (... 555 e-156
sp|Q40345|IDHP_MEDSA Isocitrate dehydrogenase [NADP], chlor... 555 e-156
gb|AAV33246.1| isocitrate dehydrogenase [Toxoplasma gondii] 555 e-156
ref|NP_001009276.1| cytosolic NADP-isocitrate dehydrogenase... 554 e-156
ref|XP_001505172.1| PREDICTED: similar to Isocitrate dehydr... 553 e-155
emb|CAB66637.1| hypothetical protein [Homo sapiens] >gi|117... 552 e-155
ref|XP_001462393.1| hypothetical protein GSPATT00027349001 ... 552 e-155
ref|XP_001168261.1| PREDICTED: isocitrate dehydrogenase 2 (... 551 e-155
emb|CAA65503.1| isocitrate dehydrogenase (NADP+) [Nicotiana... 551 e-155
emb|CAA65504.1| isocitrate dehydrogenase (NADP+) [Nicotiana... 551 e-155
emb|CAG38738.1| IDH1 [Homo sapiens] 551 e-155
ref|NP_005887.2| isocitrate dehydrogenase 1 (NADP+), solubl... 551 e-155
ref|XP_850187.1| PREDICTED: similar to Isocitrate dehydroge... 551 e-155
ref|XP_623673.2| PREDICTED: similar to Isocitrate dehydroge... 551 e-155
ref|XP_001511049.1| PREDICTED: similar to cytosolic NADP-de... 550 e-155
ref|YP_001524781.1| NADP-dependent isocitrate dehydrogenase... 550 e-155
gb|AAH93020.1| Isocitrate dehydrogenase 1 (NADP+), soluble ... 550 e-155
sp|O88844|IDHC_MOUSE Isocitrate dehydrogenase [NADP] cytopl... 550 e-155
ref|NP_196963.2| isocitrate dehydrogenase, putative / NADP+... 550 e-155
pdb|2CMJ|A Chain A, Crystal Structure Of Mouse Cytosolic Is... 550 e-154
ref|XP_001454244.1| hypothetical protein GSPATT00020509001 ... 550 e-154
emb|CAG38553.1| IDH1 [Homo sapiens] 550 e-154
ref|XP_001176537.1| PREDICTED: similar to Isocitrate dehydr... 549 e-154
ref|XP_312860.4| AGAP003168-PA [Anopheles gambiae str. PEST... 549 e-154
ref|XP_001141655.1| PREDICTED: isocitrate dehydrogenase 1 (... 549 e-154
gb|ABU41004.1| isocitrate dehydrogenase 1 [Anser anser] 549 e-154
ref|NP_851355.2| isocitrate dehydrogenase 1 (NADP+), solubl... 549 e-154
ref|YP_001296741.1| isocitrate dehydrogenase [Flavobacteriu... 549 e-154
emb|CAG02627.1| unnamed protein product [Tetraodon nigrovir... 548 e-154
ref|XP_445447.1| unnamed protein product [Candida glabrata]... 548 e-154
dbj|BAE48792.1| NADP-isocitrate dehydrogenase [Codonopsis l... 548 e-154
ref|XP_421965.2| PREDICTED: similar to cytosolic NADP-depen... 548 e-154
gb|AAD02918.1| NADP-dependent isocitrate dehydrogenase [Hom... 548 e-154
ref|XP_970446.1| PREDICTED: similar to isocitrate dehydroge... 548 e-154
ref|XP_001107627.1| PREDICTED: isocitrate dehydrogenase 1 (... 548 e-154
ref|XP_001020930.2| dehydrogenase, isocitrate/isopropylmala... 548 e-154
emb|CAH91635.1| hypothetical protein [Pongo abelii] 548 e-154
sp|Q5R9C5|IDHC_PONPY Isocitrate dehydrogenase [NADP] cytopl... 547 e-154
ref|XP_001845030.1| isocitrate dehydrogenase [Culex pipiens... 547 e-154
ref|NP_034627.3| isocitrate dehydrogenase 1 (NADP+), solubl... 547 e-154
ref|XP_968850.1| PREDICTED: similar to CG7176-PC, isoform C... 547 e-154
ref|XP_001384028.1| Isocitrate dehydrogenase [NADP], mitoch... 547 e-154
ref|XP_860853.1| PREDICTED: similar to Isocitrate dehydroge... 547 e-154
gb|AAA33978.1| NADPH-specific isocitrate dehydrogenase 547 e-154
dbj|BAC39792.1| unnamed protein product [Mus musculus] 547 e-154
dbj|BAE39644.1| unnamed protein product [Mus musculus] 547 e-154
emb|CAD97653.1| hypothetical protein [Homo sapiens] >gi|117... 547 e-154
sp|Q9Z2K8|IDHC_MICOH Isocitrate dehydrogenase [NADP] cytopl... 547 e-154
sp|Q9XSG3|IDHC_BOVIN Isocitrate dehydrogenase [NADP] cytopl... 546 e-154
ref|XP_828183.1| isocitrate dehydrogenase [Trypanosoma bruc... 546 e-153
ref|YP_745187.1| isocitrate dehydrogenase [Granulibacter be... 546 e-153
ref|YP_001233708.1| isocitrate dehydrogenase [Acidiphilium ... 546 e-153
gb|AAH88986.1| Isocitrate dehydrogenase 1 (NADP+), soluble ... 546 e-153
emb|CAA53300.1| isocitrate dehydrogenase (NADP+) [Solanum t... 546 e-153
pir||S33612 isocitrate dehydrogenase (NADP) (EC 1.1.1.42) -... 546 e-153
ref|NP_175836.1| ICDH; isocitrate dehydrogenase (NADP+) [Ar... 546 e-153
sp|Q9Z2K9|IDHC_MICME Isocitrate dehydrogenase [NADP] cytopl... 546 e-153
ref|XP_001614236.1| isocitrate dehydrogenase [NADP], mitoch... 546 e-153
sp|Q06197|IDHC_SOYBN Isocitrate dehydrogenase [NADP] (Oxalo... 546 e-153
gb|ABK25438.1| unknown [Picea sitchensis] 545 e-153
ref|YP_062774.1| isocitrate dehydrogenase [Leifsonia xyli s... 545 e-153
gb|ABI52605.1| isocitrate dehydrogenase [Gryllus firmus] 545 e-153
emb|CAH89719.1| hypothetical protein [Pongo abelii] 545 e-153
gb|AAD51361.1|AF176669_1 NADP-isocitrate dehydrogenase [Cit... 545 e-153
ref|NP_001056381.1| Os05g0573200 [Oryza sativa (japonica cu... 545 e-153
ref|NP_113698.1| isocitrate dehydrogenase 1 (NADP+), solubl... 545 e-153
emb|CAD24779.1| isocitrate dehydrogenase [Cucumis sativus] 544 e-153
dbj|BAC77064.1| NADP-specific isocitrate dehydrogenase [Lup... 544 e-153
ref|NP_001093090.1| NADPH-specific isocitrate dehydrogenase... 544 e-153
ref|XP_001841910.1| isocitrate dehydrogenase cytoplasmic [C... 544 e-153
dbj|BAA34112.1| NADP specific isocitrate dehydrogenase [Dau... 544 e-153
ref|XP_001650675.1| nadp-specific isocitrate dehydrogenase ... 544 e-153
ref|XP_710919.1| NADP-specific isocitrate dehydrogenase [Ca... 544 e-153
emb|CAA73139.1| isocitrate dehydrogenase (NADP+) [Apium gra... 544 e-153
ref|YP_117132.1| isocitrate dehydrogenase [Nocardia farcini... 543 e-153
dbj|BAC77063.1| NADP-specific isocitrate dehydrogenase [Lup... 543 e-153
gb|AAS49171.1| NADP-dependent isocitrate dehydrogenase [Pis... 543 e-153
ref|XP_001878769.1| predicted protein [Laccaria bicolor S23... 543 e-153
dbj|BAA34113.1| NADP specific isocitrate dehydrogenase [Dau... 543 e-152
gb|AAB39248.1| NADP-isocitrate dehydrogenase [Eucalyptus gl... 543 e-152
ref|XP_460289.1| hypothetical protein DEHA0E24134g [Debaryo... 542 e-152
sp|P50218|IDHC_TOBAC Isocitrate dehydrogenase [NADP] (Oxalo... 542 e-152
emb|CAB87626.1| isocitrate dehydrogenase-like protein [Arab... 542 e-152
ref|XP_569234.1| isocitrate dehydrogenase (NADP+) [Cryptoco... 542 e-152
ref|XP_459772.1| hypothetical protein DEHA0E11286g [Debaryo... 541 e-152
ref|XP_001646579.1| hypothetical protein Kpol_1055p78 [Vand... 541 e-152
ref|NP_001088022.1| hypothetical protein LOC494713 [Xenopus... 541 e-152
ref|XP_569233.1| isocitrate dehydrogenase (NADP+) [Cryptoco... 541 e-152
emb|CAN72808.1| hypothetical protein [Vitis vinifera] >gi|1... 541 e-152
ref|YP_001769504.1| isocitrate dehydrogenase, NADP-dependen... 540 e-152
emb|CAQ15240.1| isocitrate dehydrogenase 1 (NADP+), soluble... 540 e-152
ref|NP_958907.1| isocitrate dehydrogenase 1 (NADP+), solubl... 540 e-152
gb|AAT06312.1| isocitrate dehydrogenase [Rhizobium legumino... 540 e-152
ref|YP_677841.1| isocitrate dehydrogenase [Cytophaga hutchi... 540 e-152
ref|XP_001670101.1| Hypothetical protein CBG21657 [Caenorha... 540 e-151
ref|XP_645284.1| isocitrate dehydrogenase (NADP+) [Dictyost... 540 e-151
ref|YP_768215.1| isocitrate dehydrogenase [Rhizobium legumi... 539 e-151
ref|NP_984921.1| AER061Cp [Ashbya gossypii ATCC 10895] >gi|... 539 e-151
emb|CAA63220.1| isocitrate dehydrogenase (NAD+) [Solanum tu... 539 e-151
sp|P50217|IDHC_SOLTU Isocitrate dehydrogenase [NADP] (Oxalo... 539 e-151
sp|O13285|IDH1_CANTR Isocitrate dehydrogenase [NADP], mitoc... 538 e-151
ref|NP_501665.1| F59B8.2 [Caenorhabditis elegans] >gi|38778... 538 e-151
ref|ZP_01862723.1| isocitrate dehydrogenase [Erythrobacter ... 538 e-151
ref|XP_001837820.1| hypothetical protein CC1G_11465 [Coprin... 538 e-151
ref|YP_001601185.1| Isocitrate dehydrogenase [Gluconacetoba... 538 e-151
ref|ZP_02858718.1| isocitrate dehydrogenase, NADP-dependent... 537 e-151
ref|YP_001413846.1| isocitrate dehydrogenase, NADP-dependen... 537 e-151
ref|XP_504978.1| hypothetical protein [Yarrowia lipolytica]... 537 e-151
ref|YP_001609735.1| NADP-dependent isocitrate dehydrogenase... 536 e-151
ref|NP_001042583.1| Os01g0248400 [Oryza sativa (japonica cu... 536 e-151
ref|YP_001419447.1| isocitrate dehydrogenase, NADP-dependen... 536 e-150
ref|ZP_02981592.1| isocitrate dehydrogenase, NADP-dependent... 536 e-150
ref|YP_266067.1| isocitrate dehydrogenase [Candidatus Pelag... 536 e-150
ref|YP_001685152.1| isocitrate dehydrogenase, NADP-dependen... 536 e-150
ref|NP_354851.2| isocitrate dehydrogenase [Agrobacterium tu... 535 e-150
ref|NP_001040134.1| isocitrate dehydrogenase [Bombyx mori] ... 535 e-150
ref|XP_001528456.1| isocitrate dehydrogenase, mitochondrial... 535 e-150
ref|ZP_03891012.1| isocitrate dehydrogenase (NADP) [Geoderm... 534 e-150
ref|ZP_02295934.1| isocitrate dehydrogenase, NADP-dependent... 534 e-150
ref|NP_772387.1| isocitrate dehydrogenase [Bradyrhizobium j... 534 e-150
ref|XP_001365492.1| PREDICTED: similar to cytosolic NADP-de... 534 e-150
ref|ZP_02166681.1| isocitrate dehydrogenase [Hoeflea photot... 534 e-150
ref|NP_594105.1| isocitrate dehydrogenase Idp1 [Schizosacch... 534 e-150
ref|XP_713421.1| cytosolic NADP-specific isocitrate dehydro... 533 e-150
ref|YP_001538953.1| isocitrate dehydrogenase, NADP-dependen... 533 e-149
ref|ZP_01130474.1| isocitrate dehydrogenase [marine actinob... 533 e-149
ref|NP_421325.1| isocitrate dehydrogenase [Caulobacter cres... 533 e-149
gb|AAT44354.1| isocitrate dehydrogenase [Crassostrea gigas] 532 e-149
ref|NP_926944.1| isocitrate dehydrogenase [Gloeobacter viol... 532 e-149
ref|ZP_02124492.1| Isocitrate dehydrogenase (NADP(+)) [Meth... 532 e-149
gb|ABK24873.1| unknown [Picea sitchensis] 532 e-149
gb|ABA18651.1| cytosolic NADP+-isocitrate dehydrogenase [Po... 532 e-149
ref|XP_001017274.1| isocitrate dehydrogenase, NADP-dependen... 532 e-149
ref|YP_290624.1| isocitrate dehydrogenase [Thermobifida fus... 532 e-149
ref|ZP_03869030.1| isocitrate dehydrogenase (NADP) [Jonesia... 531 e-149
emb|CAO64975.1| unnamed protein product [Vitis vinifera] 531 e-149
ref|XP_001634205.1| predicted protein [Nematostella vectens... 531 e-149
gb|ABL97438.1| isocitrate dehydrogenase [uncultured marine ... 530 e-149
ref|YP_001160602.1| isocitrate dehydrogenase [Salinispora t... 530 e-149
ref|YP_425448.1| isocitrate dehydrogenase [Rhodospirillum r... 530 e-149
gb|EDT29808.1| isocitrate dehydrogenase, NADP-dependent [Ol... 530 e-149
ref|XP_725505.1| isocitrate dehydrogenase, NADP-dependent [... 530 e-148
ref|YP_002761841.1| NADP-dependent isocitrate dehydrogenase... 530 e-148
ref|YP_001709366.1| isocitrate dehydrogenase [Clavibacter m... 530 e-148
ref|YP_872148.1| isocitrate dehydrogenase [Acidothermus cel... 530 e-148
ref|NP_385898.1| isocitrate dehydrogenase [Sinorhizobium me... 530 e-148
gb|EEJ98364.1| isocitrate dehydrogenase (NADP) [Thermomonos... 529 e-148
gb|ABD36135.1| isocitrate dehydrogenase precursor [Bombyx m... 529 e-148
ref|YP_001832264.1| isocitrate dehydrogenase, NADP-dependen... 529 e-148
ref|YP_001223282.1| isocitrate dehydrogenase [Clavibacter m... 529 e-148
ref|XP_001383685.1| Isocitrate dehydrogenase [NADP] peroxis... 529 e-148
ref|YP_001623415.1| isocitrate dehydrogenase (NADP) [Reniba... 529 e-148
ref|YP_002826161.1| NADP isocitrate dehydrogenase [Rhizobiu... 529 e-148
ref|XP_001527573.1| isocitrate dehydrogenase peroxisomal [L... 529 e-148
ref|NP_176768.1| isocitrate dehydrogenase, putative / NADP+... 529 e-148
gb|AAM13090.1| similar to NADP-specific isocitrate dehydrog... 529 e-148
ref|YP_673828.1| isocitrate dehydrogenase [Mesorhizobium sp... 528 e-148
ref|ZP_03896321.1| isocitrate dehydrogenase (NADP) [Dyadoba... 528 e-148
ref|XP_001427867.1| hypothetical protein GSPATT00005218001 ... 528 e-148
gb|EAY99113.1| hypothetical protein OsI_020346 [Oryza sativ... 528 e-148
ref|YP_883449.1| isocitrate dehydrogenase [Mycobacterium av... 527 e-148
ref|NP_001053269.1| Os04g0508200 [Oryza sativa (japonica cu... 527 e-148
ref|YP_756242.1| isocitrate dehydrogenase [Maricaulis maris... 527 e-148
ref|YP_001327198.1| isocitrate dehydrogenase [Sinorhizobium... 527 e-148
ref|NP_962389.1| isocitrate dehydrogenase [Mycobacterium av... 526 e-148
emb|CAD24782.1| isocitrate dehydrogenase [Arabidopsis thali... 526 e-148
gb|AAM65674.1| isocitrate dehydrogenase, putative [Arabidop... 526 e-147
sp|O13294|IDH2_CANTR Isocitrate dehydrogenase [NADP] peroxi... 526 e-147
emb|CAE04728.1| OSJNBa0043L24.16 [Oryza sativa (japonica cu... 526 e-147
ref|YP_706173.1| isocitrate dehydrogenase [Rhodococcus sp. ... 526 e-147
ref|ZP_01018081.1| isocitrate dehydrogenase [Parvularcula b... 526 e-147
ref|XP_001354101.1| GA20156-PA [Drosophila pseudoobscura] >... 526 e-147
ref|ZP_03819206.1| isocitrate dehydrogenase (NADP) [Actinos... 526 e-147
ref|NP_539708.1| isocitrate dehydrogenase [Brucella meliten... 526 e-147
gb|AAF73472.1|AF268076_1 NADP-dependent isocitrate dehydrog... 526 e-147
ref|YP_989041.1| isocitrate dehydrogenase [Bartonella bacil... 526 e-147
ref|YP_001833636.1| isocitrate dehydrogenase, NADP-dependen... 525 e-147
ref|XP_390523.1| hypothetical protein FG10347.1 [Gibberella... 525 e-147
ref|YP_001849499.1| isocitrate dehydrogenase [NADP] Icd1 [M... 525 e-147
ref|YP_419971.1| isocitrate dehydrogenase [Magnetospirillum... 525 e-147
ref|ZP_00056387.1| COG0538: Isocitrate dehydrogenases [Magn... 525 e-147
ref|YP_033790.1| isocitrate dehydrogenase [Bartonella hense... 525 e-147
ref|XP_001485076.1| isocitrate dehydrogenase peroxisomal [P... 524 e-147
ref|YP_002783489.1| isocitrate dehydrogenase [Rhodococcus o... 524 e-147
ref|NP_698203.1| isocitrate dehydrogenase [Brucella suis 13... 523 e-147
emb|CAH67563.1| OSIGBa0101P20.6 [Oryza sativa (indica culti... 523 e-147
ref|YP_001758392.1| isocitrate dehydrogenase, NADP-dependen... 523 e-147
ref|XP_679587.1| isocitrate dehydrogenase (NADP), mitochond... 523 e-146
ref|NP_101923.1| isocitrate dehydrogenase [Mesorhizobium lo... 523 e-146
ref|YP_032403.1| isocitrate dehydrogenase [Bartonella quint... 523 e-146
ref|YP_001370537.1| isocitrate dehydrogenase, NADP-dependen... 523 e-146
emb|CAM77136.1| Isocitrate/isopropylmalate dehydrogenase [M... 522 e-146
ref|ZP_02731825.1| isocitrate dehydrogenase [Gemmata obscur... 522 e-146
ref|YP_568874.1| isocitrate dehydrogenase [Rhodopseudomonas... 522 e-146
ref|NP_949171.1| isocitrate dehydrogenase [Rhodopseudomonas... 522 e-146
ref|ZP_01228834.1| NADP dependent isocitrate dehydrogenase ... 522 e-146
ref|ZP_02963068.1| isocitrate dehydrogenase [Bifidobacteriu... 522 e-146
ref|YP_001108727.1| isocitrate dehydrogenase [Saccharopolys... 522 e-146
ref|XP_446953.1| unnamed protein product [Candida glabrata]... 522 e-146
gb|EAY58582.1| isocitrate dehydrogenase [NADP] icd1 [Mycoba... 522 e-146
ref|XP_001400371.1| precursor of mitochondrial isocitrate d... 522 e-146
ref|YP_617009.1| isocitrate dehydrogenase [Sphingopyxis ala... 522 e-146
ref|NP_217856.1| isocitrate dehydrogenase [Mycobacterium tu... 521 e-146
ref|YP_458429.1| isocitrate dehydrogenase [Erythrobacter li... 521 e-146
ref|XP_001350171.1| isocitrate dehydrogenase (NADP), mitoch... 521 e-146
ref|XP_955850.1| hypothetical protein NCU03857 [Neurospora ... 521 e-146
ref|XP_762258.1| hypothetical protein UM06111.1 [Ustilago m... 521 e-146
ref|ZP_02955422.1| isocitrate dehydrogenase, NADP-dependent... 521 e-146
ref|YP_487337.1| isocitrate dehydrogenase [Rhodopseudomonas... 521 e-146
ref|XP_001484278.1| isocitrate dehydrogenase, mitochondrial... 521 e-146
ref|ZP_01046178.1| isocitrate dehydrogenase NADP-dependent ... 521 e-146
ref|YP_979491.1| isocitrate dehydrogenase [Mycobacterium bo... 521 e-146
ref|YP_002765452.1| NADP-dependent isocitrate dehydrogenase... 520 e-146
ref|XP_445184.1| unnamed protein product [Candida glabrata]... 520 e-146
ref|XP_001226620.1| conserved hypothetical protein [Chaetom... 520 e-146
ref|YP_001241304.1| isocitrate dehydrogenase [Bradyrhizobiu... 520 e-146
ref|NP_729368.1| Isocitrate dehydrogenase CG7176-PA, isofor... 520 e-145
ref|ZP_00960755.1| Isocitrate dehydrogenase [Roseovarius nu... 519 e-145
ref|XP_754749.1| isocitrate dehydrogenase Idp1 [Aspergillus... 519 e-145
gb|EDP52872.1| isocitrate dehydrogenase Idp1, putative [Asp... 519 e-145
ref|NP_729367.1| Isocitrate dehydrogenase CG7176-PD, isofor... 519 e-145
ref|NP_729366.1| Isocitrate dehydrogenase CG7176-PB, isofor... 518 e-145
ref|NP_982520.1| AAL022Wp [Ashbya gossypii ATCC 10895] >gi|... 518 e-145
ref|ZP_02302766.1| isocitrate dehydrogenase, NADP-dependent... 518 e-145
ref|YP_576902.1| isocitrate dehydrogenase [Nitrobacter hamb... 518 e-145
ref|YP_001204807.1| isocitrate dehydrogenase [Bradyrhizobiu... 518 e-145
ref|ZP_02188085.1| Isocitrate dehydrogenase [alpha proteoba... 518 e-145
ref|YP_001363715.1| isocitrate dehydrogenase, NADP-dependen... 518 e-145
ref|NP_652044.1| Isocitrate dehydrogenase CG7176-PC, isofor... 518 e-145
ref|YP_317907.1| isocitrate dehydrogenase [Nitrobacter wino... 518 e-145
ref|YP_001260963.1| isocitrate dehydrogenase [Sphingomonas ... 517 e-145
ref|YP_496560.1| isocitrate dehydrogenase [Novosphingobium ... 517 e-145
ref|XP_367343.2| hypothetical protein MGG_07268 [Magnaporth... 516 e-145
sp|P79089|IDHP_ASPNG Isocitrate dehydrogenase [NADP], mitoc... 516 e-144
ref|ZP_01040029.1| isocitrate dehydrogenase [Erythrobacter ... 516 e-144
gb|AAK76731.1| peroxisomal NADP-dependent isocitrate dehydr... 516 e-144
gb|ABD77208.1| isocitrate dehydrogenase 1 [Mus musculus] 516 e-144
ref|NP_014389.1| Peroxisomal NADP-dependent isocitrate dehy... 516 e-144
gb|EDN62799.1| NADP-dependent isocitrate dehydrogenase [Sac... 515 e-144
gb|EDN59398.1| NADP-dependent isocitrate dehydrogenase [Sac... 515 e-144
ref|XP_001903959.1| unnamed protein product [Podospora anse... 515 e-144
>ref|XP_847200.1| isocitrate dehydrogenase [NADP], mitochondrial precursor, putative
[Trypanosoma brucei TREU927]
gb|AAX78964.1| isocitrate dehydrogenase [NADP], mitochondrial precursor, putative
[Trypanosoma brucei]
gb|AAZ13134.1| isocitrate dehydrogenase [NADP], mitochondrial precursor, putative
[Trypanosoma brucei]
Length = 437
Score = 909 bits (2348), Expect = 0.0, Method: Composition-based stats.
Identities = 437/437 (100%), Positives = 437/437 (100%)
Query: 1 MFRRVACAASSVNAGALTPRFVSTTRPSLGRIKVSGTVVDMDGDEMTRIIWALIKEKLIL 60
MFRRVACAASSVNAGALTPRFVSTTRPSLGRIKVSGTVVDMDGDEMTRIIWALIKEKLIL
Sbjct: 1 MFRRVACAASSVNAGALTPRFVSTTRPSLGRIKVSGTVVDMDGDEMTRIIWALIKEKLIL 60
Query: 61 PHVDVPIEYYDLSITSRDASNDKVTEQAAEAIQRHNVGIKCATITPDEARVKEFNLKKMW 120
PHVDVPIEYYDLSITSRDASNDKVTEQAAEAIQRHNVGIKCATITPDEARVKEFNLKKMW
Sbjct: 61 PHVDVPIEYYDLSITSRDASNDKVTEQAAEAIQRHNVGIKCATITPDEARVKEFNLKKMW 120
Query: 121 KSPNGTIRNILGGTVFREPIIVKNVPRVVPQWSEPIIVGRHAYGDQYKATESLFPPGRLE 180
KSPNGTIRNILGGTVFREPIIVKNVPRVVPQWSEPIIVGRHAYGDQYKATESLFPPGRLE
Sbjct: 121 KSPNGTIRNILGGTVFREPIIVKNVPRVVPQWSEPIIVGRHAYGDQYKATESLFPPGRLE 180
Query: 181 LVHTPANGGSPQVLEVFNFKGEGVGLAMYNTRESVEAFAESCFEYAIMRRYPLVLSTKNT 240
LVHTPANGGSPQVLEVFNFKGEGVGLAMYNTRESVEAFAESCFEYAIMRRYPLVLSTKNT
Sbjct: 181 LVHTPANGGSPQVLEVFNFKGEGVGLAMYNTRESVEAFAESCFEYAIMRRYPLVLSTKNT 240
Query: 241 ILKKYDGLFLETFQRMYDTKYREQFERLNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDG 300
ILKKYDGLFLETFQRMYDTKYREQFERLNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDG
Sbjct: 241 ILKKYDGLFLETFQRMYDTKYREQFERLNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDG 300
Query: 301 DVQSDIVAQGFGSLGLMTSVLLCPDGKTIESEAAHGTVTRHYREHQKGKETSTNSVASIF 360
DVQSDIVAQGFGSLGLMTSVLLCPDGKTIESEAAHGTVTRHYREHQKGKETSTNSVASIF
Sbjct: 301 DVQSDIVAQGFGSLGLMTSVLLCPDGKTIESEAAHGTVTRHYREHQKGKETSTNSVASIF 360
Query: 361 AWTRGLAHRGKLDGNAPLVEFASSLERATIKTIEGGHMTKDLALCVHGAAALQRSHYETT 420
AWTRGLAHRGKLDGNAPLVEFASSLERATIKTIEGGHMTKDLALCVHGAAALQRSHYETT
Sbjct: 361 AWTRGLAHRGKLDGNAPLVEFASSLERATIKTIEGGHMTKDLALCVHGAAALQRSHYETT 420
Query: 421 EVFIDSVAEELARSVKG 437
EVFIDSVAEELARSVKG
Sbjct: 421 EVFIDSVAEELARSVKG 437
>ref|XP_813368.1| isocitrate dehydrogenase [NADP], mitochondrial precursor, putative
[Trypanosoma cruzi strain CL Brener]
gb|EAN91517.1| isocitrate dehydrogenase [NADP], mitochondrial precursor, putative
[Trypanosoma cruzi]
Length = 433
Score = 751 bits (1940), Expect = 0.0, Method: Composition-based stats.
Identities = 356/434 (82%), Positives = 392/434 (90%), Gaps = 4/434 (0%)
Query: 1 MFRRVACAASSVNAGALTPRFVSTTRPSLGRIKVSGTVVDMDGDEMTRIIWALIKEKLIL 60
MFRRVAC A ++STTRP L RIKVSG VVDMDGDEMTRIIW+LIKEKLIL
Sbjct: 1 MFRRVACRVPFTAAAVC---YMSTTRPRLERIKVSGKVVDMDGDEMTRIIWSLIKEKLIL 57
Query: 61 PHVDVPIEYYDLSITSRDASNDKVTEQAAEAIQRHNVGIKCATITPDEARVKEFNLKKMW 120
P+VDVPIEYYDLSIT+RDA+NDKVTEQAAEAI RHNVGIKCATITPDEARVKEFNLKKMW
Sbjct: 58 PYVDVPIEYYDLSITNRDATNDKVTEQAAEAILRHNVGIKCATITPDEARVKEFNLKKMW 117
Query: 121 KSPNGTIRNILGGTVFREPIIVKNVPRVVPQWSEPIIVGRHAYGDQYKATESLFPPGRLE 180
KSPNGTIRNI+GGTVFREPII+KN+PRVVPQW EPIIVGRHA+GDQY AT+++FP GRLE
Sbjct: 118 KSPNGTIRNIVGGTVFREPIIIKNIPRVVPQWREPIIVGRHAFGDQYAATDAVFPAGRLE 177
Query: 181 LVHTPANGGSPQVLEVFNFKGEGVGLAMYNTRESVEAFAESCFEYAIMRRYPLVLSTKNT 240
LVHTP GGSPQVL+V+ FKGEGVGLAMYNT ES+EAFA SCFEYA++R++PLVLSTKNT
Sbjct: 178 LVHTPP-GGSPQVLDVYTFKGEGVGLAMYNTLESIEAFAVSCFEYALLRKFPLVLSTKNT 236
Query: 241 ILKKYDGLFLETFQRMYDTKYREQFERLNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDG 300
ILKKYDGLFLETFQR+YD KY++QFE+L LTY HRLIDDQVAQMIKGNGGFVWACKNYDG
Sbjct: 237 ILKKYDGLFLETFQRLYDNKYKDQFEQLKLTYTHRLIDDQVAQMIKGNGGFVWACKNYDG 296
Query: 301 DVQSDIVAQGFGSLGLMTSVLLCPDGKTIESEAAHGTVTRHYREHQKGKETSTNSVASIF 360
DVQSDIVAQGFGSLGLMTSVLL PDGKTIE+EAAHGTVTRHYRE+QKGKETSTNSVASIF
Sbjct: 297 DVQSDIVAQGFGSLGLMTSVLLRPDGKTIEAEAAHGTVTRHYREYQKGKETSTNSVASIF 356
Query: 361 AWTRGLAHRGKLDGNAPLVEFASSLERATIKTIEGGHMTKDLALCVHGAAALQRSHYETT 420
AWTRGL+HRGKLDGN L FA++LE A I+TIE G MTKDLA+C++G LQRSHYETT
Sbjct: 357 AWTRGLSHRGKLDGNPALTNFAAALELAVIRTIEAGRMTKDLAICIYGQEKLQRSHYETT 416
Query: 421 EVFIDSVAEELARS 434
F++SVA ELAR+
Sbjct: 417 HEFLESVAAELART 430
>gb|ABF20272.1| mitochondrial isocitrate dehydrogenase [Leishmania tropica]
Length = 435
Score = 705 bits (1820), Expect = 0.0, Method: Composition-based stats.
Identities = 324/436 (74%), Positives = 385/436 (88%), Gaps = 4/436 (0%)
Query: 1 MFRRVACAASSVNAGALTPRFVSTTRPSLG-RIKVSGTVVDMDGDEMTRIIWALIKEKLI 59
MFR+V+ A++S +T R S+T L RIKV VVDMDGDEMTRIIW+ IKEKLI
Sbjct: 1 MFRQVSAASAS---SLVTARSFSSTNVYLDKRIKVKNEVVDMDGDEMTRIIWSFIKEKLI 57
Query: 60 LPHVDVPIEYYDLSITSRDASNDKVTEQAAEAIQRHNVGIKCATITPDEARVKEFNLKKM 119
LP+VDVPI Y+DLS+T+RDA+NDKVT +AAEAI++ NVGIKCATITPDEARVKEFNLKKM
Sbjct: 58 LPYVDVPINYFDLSVTNRDATNDKVTVEAAEAIKKCNVGIKCATITPDEARVKEFNLKKM 117
Query: 120 WKSPNGTIRNILGGTVFREPIIVKNVPRVVPQWSEPIIVGRHAYGDQYKATESLFPPGRL 179
WKSPNGTIRNILGGTVFREPIIV N+PR+VPQW PI+VGRHA+GDQYKAT+++ PG+L
Sbjct: 118 WKSPNGTIRNILGGTVFREPIIVSNIPRIVPQWHNPIVVGRHAFGDQYKATDAVLKPGKL 177
Query: 180 ELVHTPANGGSPQVLEVFNFKGEGVGLAMYNTRESVEAFAESCFEYAIMRRYPLVLSTKN 239
+LVHTPA+G +P L+V++FKG+GVGLAMYNT+ES+E FA+SCF+YA+MR+YPLVL+TKN
Sbjct: 178 QLVHTPADGSAPTTLDVYDFKGDGVGLAMYNTKESIEGFAKSCFQYALMRKYPLVLTTKN 237
Query: 240 TILKKYDGLFLETFQRMYDTKYREQFERLNLTYVHRLIDDQVAQMIKGNGGFVWACKNYD 299
TILKKYDG+FL+TFQRMYD +Y+ FE+ +TY HRLIDDQVAQMIKG GGFVWACKNYD
Sbjct: 238 TILKKYDGMFLQTFQRMYDEQYKADFEKAGITYNHRLIDDQVAQMIKGEGGFVWACKNYD 297
Query: 300 GDVQSDIVAQGFGSLGLMTSVLLCPDGKTIESEAAHGTVTRHYREHQKGKETSTNSVASI 359
GDVQSDIVAQGFGSLGLMTSVL+CPDGKTIE+EAAHGTVTRHYR+HQ+GKETSTNSVASI
Sbjct: 298 GDVQSDIVAQGFGSLGLMTSVLMCPDGKTIEAEAAHGTVTRHYRQHQQGKETSTNSVASI 357
Query: 360 FAWTRGLAHRGKLDGNAPLVEFASSLERATIKTIEGGHMTKDLALCVHGAAALQRSHYET 419
+AWTRGLAHRGKLDGN+ LV F+ +LER +K IE GHMTKDLALCV+G++ ++R HYET
Sbjct: 358 YAWTRGLAHRGKLDGNSDLVRFSETLERVVVKAIEDGHMTKDLALCVYGSSGVKREHYET 417
Query: 420 TEVFIDSVAEELARSV 435
TE F+DSV L +++
Sbjct: 418 TEQFLDSVDAALKKAM 433
>ref|XP_001463680.1| isocitrate dehydrogenase [NADP], mitochondrial precursor, putative
[Leishmania infantum JPCM5]
emb|CAM66047.1| isocitrate dehydrogenase [NADP], mitochondrial precursor, putative
[Leishmania infantum]
Length = 435
Score = 700 bits (1807), Expect = 0.0, Method: Composition-based stats.
Identities = 314/405 (77%), Positives = 369/405 (91%)
Query: 31 RIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQAAE 90
RIKV VVDMDGDEMTRIIW+ IKEKLILP+VDVPI Y+DLS+T+RDA+NDKVT +AAE
Sbjct: 29 RIKVKNEVVDMDGDEMTRIIWSFIKEKLILPYVDVPINYFDLSVTNRDATNDKVTVEAAE 88
Query: 91 AIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRVVP 150
AI++ NVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIV N+PR+VP
Sbjct: 89 AIKKCNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVSNIPRIVP 148
Query: 151 QWSEPIIVGRHAYGDQYKATESLFPPGRLELVHTPANGGSPQVLEVFNFKGEGVGLAMYN 210
QW PI+VGRHA+GDQYKAT+++ PG+L+LVHTPA+G +P L+V++FKGEGVGLAMYN
Sbjct: 149 QWHNPIVVGRHAFGDQYKATDAVLKPGKLQLVHTPADGSAPTTLDVYDFKGEGVGLAMYN 208
Query: 211 TRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFERLNL 270
T+ES+E FA+SCF+YA+MR+YPLVL+TKNTILKKYDG+FL+TFQRMYD +Y+ FE+ +
Sbjct: 209 TKESIEGFAKSCFQYALMRKYPLVLTTKNTILKKYDGMFLQTFQRMYDEQYKADFEKAGI 268
Query: 271 TYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDGKTIE 330
TY HRLIDDQVAQMIKG GGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVL+CPDGKTIE
Sbjct: 269 TYNHRLIDDQVAQMIKGEGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLMCPDGKTIE 328
Query: 331 SEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLERATI 390
+EAAHGTVTRHYR+HQ+GKETSTNSVASI+AWTRGLAHRGKLDGN+ LV+F+ +LER +
Sbjct: 329 AEAAHGTVTRHYRQHQQGKETSTNSVASIYAWTRGLAHRGKLDGNSDLVKFSETLERVVV 388
Query: 391 KTIEGGHMTKDLALCVHGAAALQRSHYETTEVFIDSVAEELARSV 435
K IE GHMTKDLALCV+G++ ++R HYETTE F+DSV L +++
Sbjct: 389 KAIEDGHMTKDLALCVYGSSGVKREHYETTEQFLDSVDAALKKAM 433
>gb|ABF20244.1| mitochondrial isocitrate dehydrogenase [Leishmania infantum]
gb|ABF20245.1| mitochondrial isocitrate dehydrogenase [Leishmania infantum]
gb|ABF20246.1| mitochondrial isocitrate dehydrogenase [Leishmania infantum]
gb|ABF20247.1| mitochondrial isocitrate dehydrogenase [Leishmania infantum]
gb|ABF20248.1| mitochondrial isocitrate dehydrogenase [Leishmania infantum]
gb|ABF20249.1| mitochondrial isocitrate dehydrogenase [Leishmania infantum]
gb|ABF20250.1| mitochondrial isocitrate dehydrogenase [Leishmania infantum]
gb|ABF20251.1| mitochondrial isocitrate dehydrogenase [Leishmania infantum]
gb|ABF20252.1| mitochondrial isocitrate dehydrogenase [Leishmania donovani]
gb|ABF20253.1| mitochondrial isocitrate dehydrogenase [Leishmania donovani]
gb|ABF20254.1| mitochondrial isocitrate dehydrogenase [Leishmania donovani
archibaldi]
gb|ABF20255.1| mitochondrial isocitrate dehydrogenase [Leishmania donovani]
gb|ABF20256.1| mitochondrial isocitrate dehydrogenase [Leishmania donovani]
gb|ABF20257.1| mitochondrial isocitrate dehydrogenase [Leishmania infantum]
gb|ABF20258.1| mitochondrial isocitrate dehydrogenase [Leishmania infantum]
gb|ABF20259.1| mitochondrial isocitrate dehydrogenase [Leishmania donovani]
gb|ABF20260.1| mitochondrial isocitrate dehydrogenase [Leishmania donovani]
gb|ABF20261.1| mitochondrial isocitrate dehydrogenase [Leishmania infantum]
gb|ABF20262.1| mitochondrial isocitrate dehydrogenase [Leishmania infantum]
gb|ABF20263.1| mitochondrial isocitrate dehydrogenase [Leishmania infantum]
gb|ABF20264.1| mitochondrial isocitrate dehydrogenase [Leishmania infantum]
gb|ABF20265.1| mitochondrial isocitrate dehydrogenase [Leishmania infantum]
gb|ABF20266.1| mitochondrial isocitrate dehydrogenase [Leishmania infantum]
gb|ABF20267.1| mitochondrial isocitrate dehydrogenase [Leishmania donovani
archibaldi]
gb|ABF20268.1| mitochondrial isocitrate dehydrogenase [Leishmania donovani
archibaldi]
gb|ABF20269.1| mitochondrial isocitrate dehydrogenase [Leishmania donovani]
gb|ABF20270.1| mitochondrial isocitrate dehydrogenase [Leishmania infantum]
Length = 435
Score = 700 bits (1806), Expect = 0.0, Method: Composition-based stats.
Identities = 314/405 (77%), Positives = 369/405 (91%)
Query: 31 RIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQAAE 90
RIKV VVDMDGDEMTRIIW+ IKEKLILP+VDVPI Y+DLS+T+RDA+NDKVT +AAE
Sbjct: 29 RIKVKNEVVDMDGDEMTRIIWSFIKEKLILPYVDVPINYFDLSVTNRDATNDKVTVEAAE 88
Query: 91 AIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRVVP 150
AI++ NVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIV N+PR+VP
Sbjct: 89 AIKKCNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVSNIPRIVP 148
Query: 151 QWSEPIIVGRHAYGDQYKATESLFPPGRLELVHTPANGGSPQVLEVFNFKGEGVGLAMYN 210
QW PI+VGRHA+GDQYKAT+++ PG+L+LVHTPA+G +P L+V++FKGEGVGLAMYN
Sbjct: 149 QWHNPIVVGRHAFGDQYKATDAVLKPGKLQLVHTPADGSAPTTLDVYDFKGEGVGLAMYN 208
Query: 211 TRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFERLNL 270
T+ES+E FA+SCF+YA+MR+YPLVL+TKNTILKKYDG+FL+TFQRMYD +Y+ FE+ +
Sbjct: 209 TKESIEGFAKSCFQYALMRKYPLVLTTKNTILKKYDGMFLQTFQRMYDEQYKADFEKAGI 268
Query: 271 TYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDGKTIE 330
TY HRLIDDQVAQMIKG GGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVL+CPDGKTIE
Sbjct: 269 TYNHRLIDDQVAQMIKGEGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLMCPDGKTIE 328
Query: 331 SEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLERATI 390
+EAAHGTVTRHYR+HQ+GKETSTNSVASI+AWTRGLAHRGKLDGN+ LV+F+ +LER +
Sbjct: 329 AEAAHGTVTRHYRQHQQGKETSTNSVASIYAWTRGLAHRGKLDGNSDLVKFSETLERVVV 388
Query: 391 KTIEGGHMTKDLALCVHGAAALQRSHYETTEVFIDSVAEELARSV 435
K IE GHMTKDLALCV+G++ ++R HYETTE F+DSV L +++
Sbjct: 389 KAIEDGHMTKDLALCVYGSSGVKREHYETTEQFLDSVDAALKKAM 433
>ref|XP_001681361.1| isocitrate dehydrogenase [NADP], mitochondrial precursor, putative
[Leishmania major]
emb|CAJ02471.1| isocitrate dehydrogenase [NADP], mitochondrial precursor, putative
[Leishmania major]
Length = 435
Score = 699 bits (1804), Expect = 0.0, Method: Composition-based stats.
Identities = 313/405 (77%), Positives = 369/405 (91%)
Query: 31 RIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQAAE 90
RIKV VVDMDGDEMTRIIW+ IKEKLILP+VDVPI Y+DLS+T+RDA+NDKVT +AAE
Sbjct: 29 RIKVKNEVVDMDGDEMTRIIWSFIKEKLILPYVDVPINYFDLSVTNRDATNDKVTVEAAE 88
Query: 91 AIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRVVP 150
A+++ NVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIV N+PR+VP
Sbjct: 89 AVKKCNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVSNIPRIVP 148
Query: 151 QWSEPIIVGRHAYGDQYKATESLFPPGRLELVHTPANGGSPQVLEVFNFKGEGVGLAMYN 210
QW PI+VGRHA+GDQYKAT+++ PG+L+LVHTPA+G +P L+V++FKGEGVGLAMYN
Sbjct: 149 QWHNPIVVGRHAFGDQYKATDAVLKPGKLQLVHTPADGSAPTTLDVYDFKGEGVGLAMYN 208
Query: 211 TRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFERLNL 270
T+ES+E FA+SCF+YA+MR+YPLVL+TKNTILKKYDG+FL+TFQRMYD +Y+ FE+ +
Sbjct: 209 TKESIEGFAKSCFQYALMRKYPLVLTTKNTILKKYDGMFLQTFQRMYDEQYKADFEKAGI 268
Query: 271 TYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDGKTIE 330
TY HRLIDDQVAQMIKG GGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVL+CPDGKTIE
Sbjct: 269 TYNHRLIDDQVAQMIKGEGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLMCPDGKTIE 328
Query: 331 SEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLERATI 390
+EAAHGTVTRHYR+HQ+GKETSTNSVASI+AWTRGLAHRGKLDGN+ LV+F+ +LER +
Sbjct: 329 AEAAHGTVTRHYRQHQQGKETSTNSVASIYAWTRGLAHRGKLDGNSDLVKFSETLERVVV 388
Query: 391 KTIEGGHMTKDLALCVHGAAALQRSHYETTEVFIDSVAEELARSV 435
K IE GHMTKDLALCV+G++ ++R HYETTE F+DSV L +++
Sbjct: 389 KAIEDGHMTKDLALCVYGSSGVKREHYETTEQFLDSVDTALKKAM 433
>gb|ABF20271.1| mitochondrial isocitrate dehydrogenase [Leishmania gerbilli]
Length = 435
Score = 693 bits (1788), Expect = 0.0, Method: Composition-based stats.
Identities = 312/405 (77%), Positives = 367/405 (90%)
Query: 31 RIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQAAE 90
RIKV VVDMDGDEMTRIIW+ IKEKLILP+VDVPI Y+DLS+T+RDA+NDKVT +AAE
Sbjct: 29 RIKVKNEVVDMDGDEMTRIIWSSIKEKLILPYVDVPINYFDLSVTNRDATNDKVTVEAAE 88
Query: 91 AIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRVVP 150
AI++ NVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIV N+PR+VP
Sbjct: 89 AIKKCNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVSNIPRIVP 148
Query: 151 QWSEPIIVGRHAYGDQYKATESLFPPGRLELVHTPANGGSPQVLEVFNFKGEGVGLAMYN 210
QW PI+VGRHA+GDQYKAT+++ PG+L+LVHTPA+G +P L+V++FKGEGVGLAMYN
Sbjct: 149 QWHNPIVVGRHAFGDQYKATDAVLKPGKLQLVHTPADGSAPTTLDVYDFKGEGVGLAMYN 208
Query: 211 TRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFERLNL 270
T+ES+E FA+SCF+YA+MR+YPLVL+TKNTILKKYDG+FL+TFQRMYD +Y+ FE+ +
Sbjct: 209 TKESIEGFAKSCFQYALMRKYPLVLTTKNTILKKYDGMFLQTFQRMYDEQYKADFEKAGI 268
Query: 271 TYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDGKTIE 330
TY HRLIDDQVAQMIKG GGFVWACKNY GD QSDIVAQGFGSLGLMTSVL+CPDGKTIE
Sbjct: 269 TYNHRLIDDQVAQMIKGEGGFVWACKNYGGDAQSDIVAQGFGSLGLMTSVLMCPDGKTIE 328
Query: 331 SEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLERATI 390
+EAAHGTVTRHYR+HQ+GKETSTNSVASI+AWTRGLAHRGKLDGN+ LV+F+ +LER +
Sbjct: 329 AEAAHGTVTRHYRQHQQGKETSTNSVASIYAWTRGLAHRGKLDGNSDLVKFSETLERVVV 388
Query: 391 KTIEGGHMTKDLALCVHGAAALQRSHYETTEVFIDSVAEELARSV 435
K IE GHMTKDLALCV+G++ ++R HYETTE F+DSV L +++
Sbjct: 389 KAIEDGHMTKDLALCVYGSSGVKREHYETTEQFLDSVDAALKKAM 433
>ref|XP_001562802.1| isocitrate dehydrogenase [NADP], mitochondrial precursor, putative
[Leishmania braziliensis MHOM/BR/75/M2904]
emb|CAM37233.1| isocitrate dehydrogenase [NADP], mitochondrial precursor, putative
[Leishmania braziliensis]
Length = 435
Score = 687 bits (1774), Expect = 0.0, Method: Composition-based stats.
Identities = 311/417 (74%), Positives = 369/417 (88%), Gaps = 1/417 (0%)
Query: 20 RFVSTTRPSLG-RIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRD 78
R S+T LG RIKV VVDMDGDEMTRIIW+LIKEKLILP+VDVPI Y+DLS+T RD
Sbjct: 17 RAFSSTNVCLGKRIKVKNEVVDMDGDEMTRIIWSLIKEKLILPYVDVPINYFDLSVTHRD 76
Query: 79 ASNDKVTEQAAEAIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFRE 138
A+NDKVT AAEAI + NVGIKCATITPDE+RV EFNLKKMWKSPNGTIRNILGGTVFRE
Sbjct: 77 ATNDKVTVDAAEAIMKCNVGIKCATITPDESRVTEFNLKKMWKSPNGTIRNILGGTVFRE 136
Query: 139 PIIVKNVPRVVPQWSEPIIVGRHAYGDQYKATESLFPPGRLELVHTPANGGSPQVLEVFN 198
PIIV N+PR+V W EPI+VGRHA+GDQYKAT++++ PG+L+LVHTPA+G +P L+V++
Sbjct: 137 PIIVSNIPRIVKHWKEPIVVGRHAFGDQYKATDTIYKPGKLQLVHTPADGSAPTTLDVYD 196
Query: 199 FKGEGVGLAMYNTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYD 258
FK EGVG+AMYNT++S+E FA+SCF+YA+MR+YPLVL+TKNTILKKYDG+FL+TFQRMY+
Sbjct: 197 FKSEGVGMAMYNTKKSIEGFAKSCFQYALMRKYPLVLTTKNTILKKYDGVFLQTFQRMYE 256
Query: 259 TKYREQFERLNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMT 318
+Y+ FE+ +TY HRLIDDQVAQMIKG GGFVWACKNYDGDVQSDIVAQGFGSLGLMT
Sbjct: 257 EQYKSDFEKAGITYNHRLIDDQVAQMIKGEGGFVWACKNYDGDVQSDIVAQGFGSLGLMT 316
Query: 319 SVLLCPDGKTIESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPL 378
SVL+CPDGKTIE+EAAHGTVTRHYR+HQ+GKETSTNS+ASI+AWTRGLAHRGKLDGN L
Sbjct: 317 SVLMCPDGKTIEAEAAHGTVTRHYRQHQQGKETSTNSIASIYAWTRGLAHRGKLDGNCDL 376
Query: 379 VEFASSLERATIKTIEGGHMTKDLALCVHGAAALQRSHYETTEVFIDSVAEELARSV 435
V+F+ LE+ IKT+E GHMTKDLALCVHG++ ++R YETTE F++SV L +++
Sbjct: 377 VKFSDMLEKVVIKTVEDGHMTKDLALCVHGSSGVKREQYETTEEFLNSVDAALKKAM 433
>ref|XP_001698704.1| isocitrate dehydrogenase, NADP-dependent [Chlamydomonas
reinhardtii]
gb|EDO99386.1| isocitrate dehydrogenase, NADP-dependent [Chlamydomonas
reinhardtii]
Length = 483
Score = 598 bits (1543), Expect = e-169, Method: Composition-based stats.
Identities = 275/414 (66%), Positives = 338/414 (81%), Gaps = 1/414 (0%)
Query: 25 TRPSLGRIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKV 84
T + G+I V+ VVD+DGDEMTR+IW IK+KLILP++D+ I Y+DL + +RD +NDKV
Sbjct: 68 TMATAGKIHVANPVVDLDGDEMTRVIWQQIKDKLILPYLDLKIVYFDLGLPNRDKTNDKV 127
Query: 85 TEQAAEAIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKN 144
TE+AA AI+ HNVGIKCATITPDEARVKEF LKKMWKSPNGTIRNIL GTVFREPI++ N
Sbjct: 128 TEEAAYAIKEHNVGIKCATITPDEARVKEFGLKKMWKSPNGTIRNILNGTVFREPIVISN 187
Query: 145 VPRVVPQWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNFKGEG 203
+PR+VP W++PI+VGRHA+GDQYKAT+ + PG+LE++ TPA GG+P+ EV++F+G G
Sbjct: 188 IPRLVPGWTKPIVVGRHAFGDQYKATDFVVDGPGKLEMIFTPAAGGAPRKFEVYSFEGPG 247
Query: 204 VGLAMYNTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYRE 263
V + MYNT ES+ FA SCFEYA+ +R+PL LSTKNTILK YDG FL+ F Y+T+Y++
Sbjct: 248 VAMGMYNTEESIRGFASSCFEYALQKRWPLYLSTKNTILKSYDGRFLQIFAETYETQYKK 307
Query: 264 QFERLNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLC 323
Q+E + Y HRLIDD VAQ +K +GGFVWACKNYDGDVQSDIVAQG+GSLGLMTSVL+
Sbjct: 308 QYEEAGIWYEHRLIDDMVAQGLKSSGGFVWACKNYDGDVQSDIVAQGYGSLGLMTSVLVT 367
Query: 324 PDGKTIESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFAS 383
PDGKT+E+EAAHGTVTRH+RE+QKGK TSTN VASIFAWTRGLAHRGKLD NA L+++
Sbjct: 368 PDGKTVEAEAAHGTVTRHWREYQKGKPTSTNPVASIFAWTRGLAHRGKLDNNAELIQWTH 427
Query: 384 SLERATIKTIEGGHMTKDLALCVHGAAALQRSHYETTEVFIDSVAEELARSVKG 437
LE A I+TIE GHMTKDLA+CVHG + Y TE F+D+VA+ A+ G
Sbjct: 428 DLEAAVIETIEQGHMTKDLAICVHGTTKVTPDQYLNTEPFMDAVADTFAKKRGG 481
>ref|NP_786984.1| isocitrate dehydrogenase 2 (NADP+), mitochondrial [Bos taurus]
emb|CAA49207.1| isocitrate dehydrogenase (NADP+) [Bos taurus]
Length = 452
Score = 574 bits (1480), Expect = e-162, Method: Composition-based stats.
Identities = 270/444 (60%), Positives = 341/444 (76%), Gaps = 15/444 (3%)
Query: 4 RVACAASSVNAGALTPRFVSTTRPSL----------GRIKVSGTVVDMDGDEMTRIIWAL 53
R C AS + A PR + T P+L RIKV+ VV+MDGDEMTRIIW
Sbjct: 9 RSLCRASG-SGSAWAPR--ALTAPNLQEQPRRHYADKRIKVAKPVVEMDGDEMTRIIWQF 65
Query: 54 IKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQAAEAIQRHNVGIKCATITPDEARVKE 113
IKEKLILPHVDV ++Y+DL + +RD +ND+VT +A A Q+++V +KCATITPDEARV+E
Sbjct: 66 IKEKLILPHVDVQLKYFDLGLPNRDQTNDQVTIDSALATQKYSVAVKCATITPDEARVEE 125
Query: 114 FNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRVVPQWSEPIIVGRHAYGDQYKATESL 173
F LKKMWKSPNGTIRNILGGTVFREPII KN+PR+VP W++PI +GRHA+GDQYKAT+ +
Sbjct: 126 FKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYKATDFV 185
Query: 174 FP-PGRLELVHTPANGGSPQVLEVFNFKGEGVGLAMYNTRESVEAFAESCFEYAIMRRYP 232
G ++V TP +G P+ EV+NF GVG+ MYNT ES+ FA SCF+YAI +++P
Sbjct: 186 VDRAGTFKVVFTPKDGSGPKEWEVYNFPAGGVGMGMYNTDESISGFAHSCFQYAIQKKWP 245
Query: 233 LVLSTKNTILKKYDGLFLETFQRMYDTKYREQFERLNLTYVHRLIDDQVAQMIKGNGGFV 292
L +STKNTILK YDG F + FQ +++ Y+ +F++ + Y HRLIDD VAQ++K +GGFV
Sbjct: 246 LYMSTKNTILKAYDGRFKDIFQAIFEKHYKTEFDKHKIWYEHRLIDDMVAQVLKSSGGFV 305
Query: 293 WACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDGKTIESEAAHGTVTRHYREHQKGKETS 352
WACKNYDGDVQSDI+AQGFGSLGLMTSVL+CPDGKTIE+EAAHGTVTRHYREHQKG+ TS
Sbjct: 306 WACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTS 365
Query: 353 TNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLERATIKTIEGGHMTKDLALCVHGAAAL 412
TN +ASIFAWTRGL HRGKLDGN L+ FA +LE+ ++T+E G MTKDLA C+HG + +
Sbjct: 366 TNPIASIFAWTRGLEHRGKLDGNQDLIRFAQTLEKVCVETVESGAMTKDLAGCIHGLSNV 425
Query: 413 Q-RSHYETTEVFIDSVAEELARSV 435
+ H+ T F+D++ L R++
Sbjct: 426 KLNEHFLNTSDFLDTIKSNLDRAL 449
>ref|NP_766599.1| isocitrate dehydrogenase 2 (NADP+), mitochondrial [Mus musculus]
gb|AAG43538.1|AF212319_1 NADP+-specific isocitrate dehydrogenase [Mus musculus]
Length = 452
Score = 574 bits (1480), Expect = e-162, Method: Composition-based stats.
Identities = 263/407 (64%), Positives = 326/407 (80%), Gaps = 2/407 (0%)
Query: 31 RIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQAAE 90
RIKV VV+MDGDEMTRIIW IKEKLILPHVDV ++Y+DL + +RD +ND+VT +A
Sbjct: 43 RIKVEKPVVEMDGDEMTRIIWQFIKEKLILPHVDVQLKYFDLGLPNRDQTNDQVTIDSAL 102
Query: 91 AIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRVVP 150
A Q+++V +KCATITPDEARV+EF LKKMWKSPNGTIRNILGGTVFREPII KN+PR+VP
Sbjct: 103 ATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVP 162
Query: 151 QWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNFKGEGVGLAMY 209
W++PI +GRHA+GDQYKAT+ + G +LV TP +G S + EV+NF GVG+ MY
Sbjct: 163 GWTKPITIGRHAHGDQYKATDFVVDRAGTFKLVFTPKDGSSAKEWEVYNFPAGGVGMGMY 222
Query: 210 NTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFERLN 269
NT ES+ FA SCF+Y+I +++PL LSTKNTILK YDG F + FQ ++D Y+ F+R
Sbjct: 223 NTDESISGFAHSCFQYSIQKKWPLYLSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDRNK 282
Query: 270 LTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDGKTI 329
+ Y HRLIDD VAQ++K +GGFVWACKNYDGDVQSDI+AQGFGSLGLMTSVL+CPDGKTI
Sbjct: 283 IWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTI 342
Query: 330 ESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLERAT 389
E+EAAHGTVTRHYREHQKG+ TSTN +ASIFAWTRGL HRGKLDGN L+ FA +LE+
Sbjct: 343 EAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQTLEKVC 402
Query: 390 IKTIEGGHMTKDLALCVHGAAALQ-RSHYETTEVFIDSVAEELARSV 435
++T+E G MTKDLA C+HG + ++ H+ T F+D++ L R++
Sbjct: 403 VQTVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRAL 449
>pdb|1LWD|A Chain A, Crystal Structure Of Nadp-Dependent Isocitrate
Dehydrogenase From Porcine Heart Mitochondria
pdb|1LWD|B Chain B, Crystal Structure Of Nadp-Dependent Isocitrate
Dehydrogenase From Porcine Heart Mitochondria
Length = 413
Score = 573 bits (1478), Expect = e-162, Method: Composition-based stats.
Identities = 260/407 (63%), Positives = 327/407 (80%), Gaps = 2/407 (0%)
Query: 31 RIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQAAE 90
RIKV+ VV+MDGDEMTRIIW IKEKLILPHVDV ++Y+DL + +RD +ND+VT +A
Sbjct: 4 RIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDVQLKYFDLGLPNRDQTNDQVTIDSAL 63
Query: 91 AIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRVVP 150
A Q+++V +KCATITPDEARV+EF LKKMWKSPNGTIRNILGGTVFREPII KN+PR+VP
Sbjct: 64 ATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVP 123
Query: 151 QWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNFKGEGVGLAMY 209
W++PI +GRHA+GDQYKAT+ + G ++V TP +G S + EV+NF GVG+ MY
Sbjct: 124 GWTKPITIGRHAHGDQYKATDFVVDRAGTFKIVFTPKDGSSAKQWEVYNFPAGGVGMGMY 183
Query: 210 NTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFERLN 269
NT ES+ FA SCF+YAI +++PL +STKNTILK YDG F + FQ +++ Y+ F++
Sbjct: 184 NTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFEKHYKTDFDKYK 243
Query: 270 LTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDGKTI 329
+ Y HRLIDD VAQ++K +GGFVWACKNYDGDVQSDI+AQGFGSLGLMTSVL+CPDGKTI
Sbjct: 244 IWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTI 303
Query: 330 ESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLERAT 389
E+EAAHGTVTRHYREHQKG+ TSTN +ASIFAWTRGL HRGKLDGN L+ FA +LE+
Sbjct: 304 EAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQTLEKVC 363
Query: 390 IKTIEGGHMTKDLALCVHGAAALQ-RSHYETTEVFIDSVAEELARSV 435
++T+E G MTKDLA C+HG + ++ H+ T F+D++ L R++
Sbjct: 364 VETVESGAMTKDLAGCIHGLSNVKLNEHFLNTSDFLDTIKSNLDRAL 410
>sp|Q04467|IDHP_BOVIN Isocitrate dehydrogenase [NADP], mitochondrial precursor
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) (IDP) (ICD-M)
gb|AAI02510.1| Isocitrate dehydrogenase 2 (NADP+), mitochondrial [Bos taurus]
Length = 452
Score = 573 bits (1477), Expect = e-162, Method: Composition-based stats.
Identities = 260/407 (63%), Positives = 328/407 (80%), Gaps = 2/407 (0%)
Query: 31 RIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQAAE 90
RIKV+ VV+MDGDEMTRIIW IKEKLILPHVDV ++Y+DL + +RD +ND+VT +A
Sbjct: 43 RIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDVQLKYFDLGLPNRDQTNDQVTIDSAL 102
Query: 91 AIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRVVP 150
A Q+++V +KCATITPDEARV+EF LKKMWKSPNGTIRNILGGTVFREPII KN+PR+VP
Sbjct: 103 ATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVP 162
Query: 151 QWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNFKGEGVGLAMY 209
W++PI +GRHA+GDQYKAT+ + G ++V TP +G P+ EV+NF GVG+ MY
Sbjct: 163 GWTKPITIGRHAHGDQYKATDFVVDRAGTFKVVFTPKDGSGPKEWEVYNFPAGGVGMGMY 222
Query: 210 NTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFERLN 269
NT ES+ FA SCF+YAI +++PL +STKNTILK YDG F + FQ +++ Y+ +F++
Sbjct: 223 NTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQAIFEKHYKTEFDKHK 282
Query: 270 LTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDGKTI 329
+ Y HRLIDD VAQ++K +GGFVWACKNYDGDVQSDI+AQGFGSLGLMTSVL+CPDGKTI
Sbjct: 283 IWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTI 342
Query: 330 ESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLERAT 389
E+EAAHGTVTRHYREHQKG+ TSTN +ASIFAWTRGL HRGKLDGN L+ FA +LE+
Sbjct: 343 EAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQTLEKVC 402
Query: 390 IKTIEGGHMTKDLALCVHGAAALQ-RSHYETTEVFIDSVAEELARSV 435
++T+E G MTKDLA C+HG + ++ H+ T F+D++ L R++
Sbjct: 403 VETVESGAMTKDLAGCIHGLSNVKLNEHFLNTSDFLDTIKSNLDRAL 449
>sp|P54071|IDHP_MOUSE Isocitrate dehydrogenase [NADP], mitochondrial precursor
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) (IDP) (ICD-M)
dbj|BAC40149.1| unnamed protein product [Mus musculus]
gb|AAH60030.1| Isocitrate dehydrogenase 2 (NADP+), mitochondrial [Mus musculus]
dbj|BAE41142.1| unnamed protein product [Mus musculus]
dbj|BAE36505.1| unnamed protein product [Mus musculus]
dbj|BAE26628.1| unnamed protein product [Mus musculus]
gb|EDL07035.1| isocitrate dehydrogenase 2 (NADP+), mitochondrial, isoform CRA_d
[Mus musculus]
Length = 452
Score = 573 bits (1476), Expect = e-161, Method: Composition-based stats.
Identities = 262/407 (64%), Positives = 326/407 (80%), Gaps = 2/407 (0%)
Query: 31 RIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQAAE 90
RIKV VV+MDGDEMTRIIW IKEKLILPHVDV ++Y+DL + +RD +ND+VT +A
Sbjct: 43 RIKVEKPVVEMDGDEMTRIIWQFIKEKLILPHVDVQLKYFDLGLPNRDQTNDQVTIDSAL 102
Query: 91 AIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRVVP 150
A Q+++V +KCATITPDEARV+EF LKKMWKSPNGTIRNILGGTVFREPII KN+PR+VP
Sbjct: 103 ATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVP 162
Query: 151 QWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNFKGEGVGLAMY 209
W++PI +GRHA+GDQYKAT+ + G +LV TP +G S + EV+NF GVG+ MY
Sbjct: 163 GWTKPITIGRHAHGDQYKATDFVVDRAGTFKLVFTPKDGSSAKEWEVYNFPAGGVGMGMY 222
Query: 210 NTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFERLN 269
NT ES+ FA SCF+Y+I +++PL LSTKNTILK YDG F + FQ ++D Y+ F++
Sbjct: 223 NTDESISGFAHSCFQYSIQKKWPLYLSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNK 282
Query: 270 LTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDGKTI 329
+ Y HRLIDD VAQ++K +GGFVWACKNYDGDVQSDI+AQGFGSLGLMTSVL+CPDGKTI
Sbjct: 283 IWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTI 342
Query: 330 ESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLERAT 389
E+EAAHGTVTRHYREHQKG+ TSTN +ASIFAWTRGL HRGKLDGN L+ FA +LE+
Sbjct: 343 EAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQTLEKVC 402
Query: 390 IKTIEGGHMTKDLALCVHGAAALQ-RSHYETTEVFIDSVAEELARSV 435
++T+E G MTKDLA C+HG + ++ H+ T F+D++ L R++
Sbjct: 403 VQTVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRAL 449
>sp|P33198|IDHP_PIG Isocitrate dehydrogenase [NADP], mitochondrial precursor
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) (IDP) (ICD-M)
gb|AAA31089.1| NADPH-specific isocitrate dehydrogenase
Length = 421
Score = 573 bits (1476), Expect = e-161, Method: Composition-based stats.
Identities = 260/407 (63%), Positives = 327/407 (80%), Gaps = 2/407 (0%)
Query: 31 RIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQAAE 90
RIKV+ VV+MDGDEMTRIIW IKEKLILPHVDV ++Y+DL + +RD +ND+VT +A
Sbjct: 12 RIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDVQLKYFDLGLPNRDQTNDQVTIDSAL 71
Query: 91 AIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRVVP 150
A Q+++V +KCATITPDEARV+EF LKKMWKSPNGTIRNILGGTVFREPII KN+PR+VP
Sbjct: 72 ATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVP 131
Query: 151 QWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNFKGEGVGLAMY 209
W++PI +GRHA+GDQYKAT+ + G ++V TP +G S + EV+NF GVG+ MY
Sbjct: 132 GWTKPITIGRHAHGDQYKATDFVVDRAGTFKIVFTPKDGSSAKQWEVYNFPAGGVGMGMY 191
Query: 210 NTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFERLN 269
NT ES+ FA SCF+YAI +++PL +STKNTILK YDG F + FQ +++ Y+ F++
Sbjct: 192 NTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFEKHYKTDFDKYK 251
Query: 270 LTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDGKTI 329
+ Y HRLIDD VAQ++K +GGFVWACKNYDGDVQSDI+AQGFGSLGLMTSVL+CPDGKTI
Sbjct: 252 IWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTI 311
Query: 330 ESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLERAT 389
E+EAAHGTVTRHYREHQKG+ TSTN +ASIFAWTRGL HRGKLDGN L+ FA +LE+
Sbjct: 312 EAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQTLEKVC 371
Query: 390 IKTIEGGHMTKDLALCVHGAAALQ-RSHYETTEVFIDSVAEELARSV 435
++T+E G MTKDLA C+HG + ++ H+ T F+D++ L R++
Sbjct: 372 VETVESGAMTKDLAGCIHGLSNVKLNEHFLNTSDFLDTIKSNLDRAL 418
>ref|NP_001026770.1| hypothetical protein LOC431056 [Gallus gallus]
emb|CAG31511.1| hypothetical protein [Gallus gallus]
Length = 452
Score = 572 bits (1475), Expect = e-161, Method: Composition-based stats.
Identities = 260/407 (63%), Positives = 329/407 (80%), Gaps = 2/407 (0%)
Query: 31 RIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQAAE 90
RIKV+ VV+MDGDEMTRIIWA IKEKLILP+VDV ++Y+DL + RD ++D+VT +A
Sbjct: 43 RIKVANPVVEMDGDEMTRIIWAFIKEKLILPNVDVQLKYFDLGLPHRDKTDDQVTIDSAL 102
Query: 91 AIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRVVP 150
A ++++V +KCATITPDEARV+EF LKKMWKSPNGTIRNILGGTVFREPII KN+PR+VP
Sbjct: 103 ATKKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVP 162
Query: 151 QWSEPIIVGRHAYGDQYKATESLF-PPGRLELVHTPANGGSPQVLEVFNFKGEGVGLAMY 209
W++PI +GRHA+GDQYKAT+ + G ++V TP +G + EVFNF G GVG+ MY
Sbjct: 163 GWTQPITIGRHAHGDQYKATDFVVNKSGTFKMVFTPKDGSGVKEWEVFNFPGGGVGMGMY 222
Query: 210 NTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFERLN 269
NT ES+ FA SCF+YAI +++PL +STKNTILK YDG F + FQ ++D Y+ +F++L
Sbjct: 223 NTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTEFDKLK 282
Query: 270 LTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDGKTI 329
+ Y HRLIDD VAQ++K +GGFVWACKNYDGDVQSDI+AQGFGSLGLMTSVL+CPDGKTI
Sbjct: 283 IWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTI 342
Query: 330 ESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLERAT 389
E+EAAHGTVTRHYREHQKG+ TSTN +ASIFAWTRGL HRGKLD N L++FA +LE+
Sbjct: 343 EAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDSNPELIKFAQTLEKVC 402
Query: 390 IKTIEGGHMTKDLALCVHGAAALQ-RSHYETTEVFIDSVAEELARSV 435
++T+E G MTKDLA C+HG A ++ H+ T F+D++ L +++
Sbjct: 403 VETVESGTMTKDLAGCIHGLANVKLNEHFVNTTDFLDAIKNTLDKAL 449
>ref|XP_001369305.1| PREDICTED: hypothetical protein [Monodelphis domestica]
Length = 455
Score = 572 bits (1473), Expect = e-161, Method: Composition-based stats.
Identities = 260/407 (63%), Positives = 324/407 (79%), Gaps = 2/407 (0%)
Query: 31 RIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQAAE 90
RIKV VV+MDGDEMTRIIW IKEKLILPHVDV ++Y+DL + RD ++D+VT +A
Sbjct: 46 RIKVDKPVVEMDGDEMTRIIWQFIKEKLILPHVDVQLKYFDLGLPHRDQTDDQVTIDSAL 105
Query: 91 AIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRVVP 150
A Q+++V +KCATITPDEARV+EF LKKMWKSPNGTIRNILGGTVFREPII KN+PR+VP
Sbjct: 106 ATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVP 165
Query: 151 QWSEPIIVGRHAYGDQYKATESLF-PPGRLELVHTPANGGSPQVLEVFNFKGEGVGLAMY 209
W+ PI +GRHA+GDQYKAT+ + G ++V TP +G + EV+NF GVG+ MY
Sbjct: 166 GWTRPITIGRHAHGDQYKATDFVVDKAGTFKMVFTPKDGSGAKEWEVYNFPAGGVGMGMY 225
Query: 210 NTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFERLN 269
NT ES+ FA SCF+YAI +++PL +STKNTILK YDG F + FQ ++D Y+ F++
Sbjct: 226 NTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNK 285
Query: 270 LTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDGKTI 329
+ Y HRLIDD VAQ++K NGGFVWACKNYDGDVQSDI+AQGFGSLGLMTSVL+CPDGKTI
Sbjct: 286 IWYEHRLIDDMVAQVLKSNGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTI 345
Query: 330 ESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLERAT 389
E+EAAHGTVTRHYREHQKG+ TSTN +ASIFAWTRGL HRGKLDGN L++FA +LE+
Sbjct: 346 EAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIKFAQTLEKVC 405
Query: 390 IKTIEGGHMTKDLALCVHGAAALQ-RSHYETTEVFIDSVAEELARSV 435
++T+E G MTKDLA C+HG + ++ HY T F+D++ L +++
Sbjct: 406 VQTVESGAMTKDLAGCIHGLSNVKLNEHYLNTGDFLDTIKNNLDKAL 452
>ref|NP_001014183.1| isocitrate dehydrogenase 2 (NADP+), mitochondrial [Rattus
norvegicus]
sp|P56574|IDHP_RAT Isocitrate dehydrogenase [NADP], mitochondrial precursor
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) (IDP) (ICD-M)
gb|AAH76398.1| Similar to NADP+-specific isocitrate dehydrogenase [Rattus
norvegicus]
gb|EDM08608.1| similar to NADP+-specific isocitrate dehydrogenase, isoform CRA_b
[Rattus norvegicus]
Length = 452
Score = 571 bits (1471), Expect = e-161, Method: Composition-based stats.
Identities = 260/407 (63%), Positives = 325/407 (79%), Gaps = 2/407 (0%)
Query: 31 RIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQAAE 90
RIKV VV+MDGDEMTRIIW IKEKLILPHVDV ++Y+DL + +RD +ND+VT +A
Sbjct: 43 RIKVEKPVVEMDGDEMTRIIWQFIKEKLILPHVDVQLKYFDLGLPNRDQTNDQVTIDSAL 102
Query: 91 AIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRVVP 150
A Q+++V +KCATITPDEARV+EF LKKMWKSPNGTIRNILGGTVFREPII KN+PR+VP
Sbjct: 103 ATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVP 162
Query: 151 QWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNFKGEGVGLAMY 209
W++PI +GRHA+GDQYKAT+ + G +LV TP +G + EV+NF GVG+ MY
Sbjct: 163 GWTKPITIGRHAHGDQYKATDFVVDRAGMFKLVFTPKDGSGAKEWEVYNFPAGGVGMGMY 222
Query: 210 NTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFERLN 269
NT ES+ FA SCF+Y+I +++PL LSTKNTI+K YDG F + FQ ++D Y+ F++
Sbjct: 223 NTDESISGFAHSCFQYSIQKKWPLYLSTKNTIMKAYDGRFKDIFQEIFDKHYKTDFDKNK 282
Query: 270 LTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDGKTI 329
+ Y HRLIDD VAQ++K +GGFVWACKNYDGDVQSDI+AQGFGSLGLMTSVL+CPDGKTI
Sbjct: 283 IWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTI 342
Query: 330 ESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLERAT 389
E+EAAHGTVTRHYREHQKG+ TSTN +ASIFAWTRGL HRGKLDGN L+ FA +LE+
Sbjct: 343 EAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQTLEKVC 402
Query: 390 IKTIEGGHMTKDLALCVHGAAALQ-RSHYETTEVFIDSVAEELARSV 435
++T+E G MTKDLA C+HG + ++ H+ T F+D++ L R++
Sbjct: 403 VQTVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRAL 449
>gb|ACO14046.1| Isocitrate dehydrogenase, mitochondrial precursor [Esox lucius]
Length = 451
Score = 571 bits (1471), Expect = e-161, Method: Composition-based stats.
Identities = 270/439 (61%), Positives = 337/439 (76%), Gaps = 12/439 (2%)
Query: 6 ACAASSVNAGALTPRFVSTTRPSL-------GRIKVSGTVVDMDGDEMTRIIWALIKEKL 58
+ A S + L P VST PSL RIKVS VV+MDGDEMTRIIW IKEKL
Sbjct: 14 SAATFSKSPAVLAP--VSTC-PSLQQRNYGDKRIKVSQPVVEMDGDEMTRIIWEFIKEKL 70
Query: 59 ILPHVDVPIEYYDLSITSRDASNDKVTEQAAEAIQRHNVGIKCATITPDEARVKEFNLKK 118
IL +VDV ++YYDL + RD +ND+VT +A A Q+++V +KCATITPDEARV+EF LKK
Sbjct: 71 ILSNVDVELKYYDLGLPYRDQTNDQVTIDSALATQKYHVAVKCATITPDEARVEEFKLKK 130
Query: 119 MWKSPNGTIRNILGGTVFREPIIVKNVPRVVPQWSEPIIVGRHAYGDQYKATESLF-PPG 177
MWKSPNGTIRNILGGTVFREPII KN+PR+VP W++PI +GRHA+GDQY+AT+ + PG
Sbjct: 131 MWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTQPITIGRHAFGDQYRATDFVVNQPG 190
Query: 178 RLELVHTPANGGSPQVLEVFNFKGEGVGLAMYNTRESVEAFAESCFEYAIMRRYPLVLST 237
++V +P +G Q V+NF G G G+ MYNT ES+ FA SCF+YAI +++PL LST
Sbjct: 191 TFKMVFSPTDGSKGQEWGVYNFPGGGCGMGMYNTDESISGFAHSCFQYAIGKKWPLYLST 250
Query: 238 KNTILKKYDGLFLETFQRMYDTKYREQFERLNLTYVHRLIDDQVAQMIKGNGGFVWACKN 297
KNTILK YDG F + F+ ++ Y+ +F++L + Y HRLIDD VAQ++K +G FVWACKN
Sbjct: 251 KNTILKAYDGRFKDIFEEIFQANYKPEFDKLKIWYEHRLIDDMVAQVLKSDGAFVWACKN 310
Query: 298 YDGDVQSDIVAQGFGSLGLMTSVLLCPDGKTIESEAAHGTVTRHYREHQKGKETSTNSVA 357
YDGDVQSDI+AQGFGSLGLMTSVL+CPDGKTIE+EAAHGTVTRHYREHQKG TSTN +A
Sbjct: 311 YDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGNPTSTNPIA 370
Query: 358 SIFAWTRGLAHRGKLDGNAPLVEFASSLERATIKTIEGGHMTKDLALCVHGAAALQ-RSH 416
SIFAWTRGL HRGKLDGN L++FA +LER ++T+E G MTKDLA C+HG + + H
Sbjct: 371 SIFAWTRGLEHRGKLDGNPDLIKFALTLERVCVETVESGVMTKDLAGCIHGLSKCKLNEH 430
Query: 417 YETTEVFIDSVAEELARSV 435
Y TE F+D++ + L +++
Sbjct: 431 YVNTEDFLDAIKKNLDKAL 449
>gb|EAX02083.1| isocitrate dehydrogenase 2 (NADP+), mitochondrial, isoform CRA_b
[Homo sapiens]
Length = 422
Score = 570 bits (1469), Expect = e-161, Method: Composition-based stats.
Identities = 261/418 (62%), Positives = 329/418 (78%), Gaps = 2/418 (0%)
Query: 20 RFVSTTRPSLGRIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDA 79
R VS + RIKV+ VV+MDGDEMTRIIW IKEKLILPHVD+ ++Y+DL + +RD
Sbjct: 2 RCVSLLLDADKRIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQ 61
Query: 80 SNDKVTEQAAEAIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREP 139
++D+VT +A A Q+++V +KCATITPDEARV+EF LKKMWKSPNGTIRNILGGTVFREP
Sbjct: 62 TDDQVTIDSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREP 121
Query: 140 IIVKNVPRVVPQWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFN 198
II KN+PR+VP W++PI +GRHA+GDQYKAT+ + G ++V TP +G + EV+N
Sbjct: 122 IICKNIPRLVPGWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYN 181
Query: 199 FKGEGVGLAMYNTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYD 258
F GVG+ MYNT ES+ FA SCF+YAI +++PL +STKNTILK YDG F + FQ ++D
Sbjct: 182 FPAGGVGMGMYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFD 241
Query: 259 TKYREQFERLNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMT 318
Y+ F++ + Y HRLIDD VAQ++K +GGFVWACKNYDGDVQSDI+AQGFGSLGLMT
Sbjct: 242 KHYKTDFDKNKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMT 301
Query: 319 SVLLCPDGKTIESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPL 378
SVL+CPDGKTIE+EAAHGTVTRHYREHQKG+ TSTN +ASIFAWTRGL HRGKLDGN L
Sbjct: 302 SVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDL 361
Query: 379 VEFASSLERATIKTIEGGHMTKDLALCVHGAAALQ-RSHYETTEVFIDSVAEELARSV 435
+ FA LE+ ++T+E G MTKDLA C+HG + ++ H+ T F+D++ L R++
Sbjct: 362 IRFAQMLEKVCVETVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRAL 419
>ref|XP_001168316.1| PREDICTED: isocitrate dehydrogenase 2 (NADP+), mitochondrial
isoform 3 [Pan troglodytes]
Length = 415
Score = 569 bits (1466), Expect = e-160, Method: Composition-based stats.
Identities = 258/407 (63%), Positives = 326/407 (80%), Gaps = 2/407 (0%)
Query: 31 RIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQAAE 90
RIKV+ VV+MDGDEMTRIIW IKEKLILPHVD+ ++Y+DL + +RD ++D+VT +A
Sbjct: 6 RIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSAL 65
Query: 91 AIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRVVP 150
A Q+++V +KCATITPDEARV+EF LKKMWKSPNGTIRNILGGTVFREPII KN+PR+VP
Sbjct: 66 ATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVP 125
Query: 151 QWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNFKGEGVGLAMY 209
W++PI +GRHA+GDQYKAT+ + G ++V TP +G + EV+NF GVG+ MY
Sbjct: 126 GWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMY 185
Query: 210 NTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFERLN 269
NT ES+ FA SCF+YAI +++PL +STKNTILK YDG F + FQ ++D Y+ F++
Sbjct: 186 NTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNK 245
Query: 270 LTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDGKTI 329
+ Y HRLIDD VAQ++K +GGFVWACKNYDGDVQSDI+AQGFGSLGLMTSVL+CPDGKTI
Sbjct: 246 IWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTI 305
Query: 330 ESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLERAT 389
E+EAAHGTVTRHYREHQKG+ TSTN +ASIFAWTRGL HRGKLDGN L+ FA +LE+
Sbjct: 306 EAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQTLEKVC 365
Query: 390 IKTIEGGHMTKDLALCVHGAAALQ-RSHYETTEVFIDSVAEELARSV 435
++T+E G MTKDLA C+HG + ++ H+ T F+D++ L R++
Sbjct: 366 VETVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRAL 412
>ref|XP_001095686.1| PREDICTED: isocitrate dehydrogenase 2 (NADP+), mitochondrial
[Macaca mulatta]
sp|Q4R502|IDHP_MACFA Isocitrate dehydrogenase [NADP], mitochondrial precursor
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) (IDP) (ICD-M)
dbj|BAE01823.1| unnamed protein product [Macaca fascicularis]
Length = 452
Score = 567 bits (1462), Expect = e-160, Method: Composition-based stats.
Identities = 258/407 (63%), Positives = 326/407 (80%), Gaps = 2/407 (0%)
Query: 31 RIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQAAE 90
RIKV+ VV+MDGDEMTRIIW IKEKLILPHVD+ ++Y+DL + +RD ++D+VT +A
Sbjct: 43 RIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSAL 102
Query: 91 AIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRVVP 150
A Q+++V +KCATITPDEARV+EF LKKMWKSPNGTIRNILGGTVFREPII KN+PR+VP
Sbjct: 103 ATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVP 162
Query: 151 QWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNFKGEGVGLAMY 209
W++PI +GRHA+GDQYKAT+ + G ++V TP +G + EV+NF GVG+ MY
Sbjct: 163 GWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMY 222
Query: 210 NTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFERLN 269
NT ES+ FA SCF+YAI +++PL +STKNTILK YDG F + FQ ++D Y+ F++
Sbjct: 223 NTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNK 282
Query: 270 LTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDGKTI 329
+ Y HRLIDD VAQ++K +GGFVWACKNYDGDVQSDI+AQGFGSLGLMTSVL+CPDGKTI
Sbjct: 283 IWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTI 342
Query: 330 ESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLERAT 389
E+EAAHGTVTRHYREHQKG+ TSTN +ASIFAWTRGL HRGKLDGN L+ FA +LE+
Sbjct: 343 EAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQTLEKVC 402
Query: 390 IKTIEGGHMTKDLALCVHGAAALQ-RSHYETTEVFIDSVAEELARSV 435
++T+E G MTKDLA C+HG + ++ H+ T F+D++ L R++
Sbjct: 403 VETVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRAL 449
>ref|XP_510589.2| PREDICTED: isocitrate dehydrogenase 2 (NADP+), mitochondrial
isoform 4 [Pan troglodytes]
Length = 452
Score = 567 bits (1462), Expect = e-160, Method: Composition-based stats.
Identities = 258/407 (63%), Positives = 326/407 (80%), Gaps = 2/407 (0%)
Query: 31 RIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQAAE 90
RIKV+ VV+MDGDEMTRIIW IKEKLILPHVD+ ++Y+DL + +RD ++D+VT +A
Sbjct: 43 RIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSAL 102
Query: 91 AIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRVVP 150
A Q+++V +KCATITPDEARV+EF LKKMWKSPNGTIRNILGGTVFREPII KN+PR+VP
Sbjct: 103 ATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVP 162
Query: 151 QWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNFKGEGVGLAMY 209
W++PI +GRHA+GDQYKAT+ + G ++V TP +G + EV+NF GVG+ MY
Sbjct: 163 GWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMY 222
Query: 210 NTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFERLN 269
NT ES+ FA SCF+YAI +++PL +STKNTILK YDG F + FQ ++D Y+ F++
Sbjct: 223 NTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNK 282
Query: 270 LTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDGKTI 329
+ Y HRLIDD VAQ++K +GGFVWACKNYDGDVQSDI+AQGFGSLGLMTSVL+CPDGKTI
Sbjct: 283 IWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTI 342
Query: 330 ESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLERAT 389
E+EAAHGTVTRHYREHQKG+ TSTN +ASIFAWTRGL HRGKLDGN L+ FA +LE+
Sbjct: 343 EAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQTLEKVC 402
Query: 390 IKTIEGGHMTKDLALCVHGAAALQ-RSHYETTEVFIDSVAEELARSV 435
++T+E G MTKDLA C+HG + ++ H+ T F+D++ L R++
Sbjct: 403 VETVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRAL 449
>ref|XP_536192.2| PREDICTED: similar to isocitrate dehydrogenase 2 (NADP+),
mitochondrial [Canis familiaris]
Length = 517
Score = 567 bits (1461), Expect = e-160, Method: Composition-based stats.
Identities = 257/407 (63%), Positives = 327/407 (80%), Gaps = 2/407 (0%)
Query: 31 RIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQAAE 90
RIKV+ VV+MDGDEMTRIIW IKEKLILPHVDV ++Y+DL + +RD +ND+VT +A
Sbjct: 109 RIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDVQLKYFDLGLPNRDQTNDQVTIDSAL 168
Query: 91 AIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRVVP 150
A Q+++V +KCATITPDEARV+EF LKKMWKSPNGTIRNILGGTVFREPII KN+PR+VP
Sbjct: 169 ATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVP 228
Query: 151 QWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNFKGEGVGLAMY 209
W++PI +GRHA+GDQYKAT+ + G +++ +P +G + EV+NF G GVG+ MY
Sbjct: 229 GWTKPITIGRHAHGDQYKATDFVVDRAGTFKIIFSPKDGSGAKEWEVYNFPGGGVGMGMY 288
Query: 210 NTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFERLN 269
NT ES+ FA SCF+YAI +++PL +STKNTILK YDG F + FQ +++ Y+ F++
Sbjct: 289 NTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFEKHYKTDFDKNK 348
Query: 270 LTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDGKTI 329
+ Y HRLIDD VAQ++K +GGFVWACKNYDGDVQSDI+AQGFGSLGLMTSVL+CPDGKTI
Sbjct: 349 IWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTI 408
Query: 330 ESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLERAT 389
E+EAAHGTVTRHYREHQKG+ TSTN +ASIFAWTRGL HRGKLDGN L+ FA +LE+
Sbjct: 409 EAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQTLEKVC 468
Query: 390 IKTIEGGHMTKDLALCVHGAAALQ-RSHYETTEVFIDSVAEELARSV 435
++T+E G MTKDLA C+HG + ++ H+ T F+D++ L +++
Sbjct: 469 VQTVESGAMTKDLAGCIHGLSNVKLNEHFLNTSDFLDTIKNNLDKAL 515
>ref|NP_002159.2| isocitrate dehydrogenase 2 (NADP+), mitochondrial precursor [Homo
sapiens]
sp|P48735|IDHP_HUMAN Isocitrate dehydrogenase [NADP], mitochondrial precursor
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) (IDP) (ICD-M)
gb|AAH09244.1| Isocitrate dehydrogenase 2 (NADP+), mitochondrial [Homo sapiens]
gb|AAH71828.1| Isocitrate dehydrogenase 2 (NADP+), mitochondrial [Homo sapiens]
gb|EAX02082.1| isocitrate dehydrogenase 2 (NADP+), mitochondrial, isoform CRA_a
[Homo sapiens]
gb|ABM83743.1| isocitrate dehydrogenase 2 (NADP+), mitochondrial [synthetic
construct]
gb|ABM87062.1| isocitrate dehydrogenase 2 (NADP+), mitochondrial [synthetic
construct]
Length = 452
Score = 567 bits (1460), Expect = e-160, Method: Composition-based stats.
Identities = 258/407 (63%), Positives = 325/407 (79%), Gaps = 2/407 (0%)
Query: 31 RIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQAAE 90
RIKV+ VV+MDGDEMTRIIW IKEKLILPHVD+ ++Y+DL + +RD ++D+VT +A
Sbjct: 43 RIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSAL 102
Query: 91 AIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRVVP 150
A Q+++V +KCATITPDEARV+EF LKKMWKSPNGTIRNILGGTVFREPII KN+PR+VP
Sbjct: 103 ATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVP 162
Query: 151 QWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNFKGEGVGLAMY 209
W++PI +GRHA+GDQYKAT+ + G ++V TP +G + EV+NF GVG+ MY
Sbjct: 163 GWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMY 222
Query: 210 NTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFERLN 269
NT ES+ FA SCF+YAI +++PL +STKNTILK YDG F + FQ ++D Y+ F++
Sbjct: 223 NTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNK 282
Query: 270 LTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDGKTI 329
+ Y HRLIDD VAQ++K +GGFVWACKNYDGDVQSDI+AQGFGSLGLMTSVL+CPDGKTI
Sbjct: 283 IWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTI 342
Query: 330 ESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLERAT 389
E+EAAHGTVTRHYREHQKG+ TSTN +ASIFAWTRGL HRGKLDGN L+ FA LE+
Sbjct: 343 EAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQMLEKVC 402
Query: 390 IKTIEGGHMTKDLALCVHGAAALQ-RSHYETTEVFIDSVAEELARSV 435
++T+E G MTKDLA C+HG + ++ H+ T F+D++ L R++
Sbjct: 403 VETVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRAL 449
>emb|CAA49208.1| isocitrate dehydrogenase (NADP+) [Homo sapiens]
Length = 452
Score = 567 bits (1460), Expect = e-159, Method: Composition-based stats.
Identities = 258/407 (63%), Positives = 325/407 (79%), Gaps = 2/407 (0%)
Query: 31 RIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQAAE 90
RIKV+ VV+MDGDEMTRIIW IKEKLILPHVD+ ++Y+DL + +RD ++D+VT +A
Sbjct: 43 RIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSAL 102
Query: 91 AIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRVVP 150
A Q+++V +KCATITPDEARV+EF LKKMWKSPNGTIRNILGGTVFREPII KN+PR+VP
Sbjct: 103 ATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVP 162
Query: 151 QWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNFKGEGVGLAMY 209
W++PI +GRHA+GDQYKAT+ + G ++V TP +G + EV+NF GVG+ MY
Sbjct: 163 GWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMY 222
Query: 210 NTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFERLN 269
NT ES+ FA SCF+YAI +++PL +STKNTILK YDG F + FQ ++D Y+ F++
Sbjct: 223 NTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNK 282
Query: 270 LTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDGKTI 329
+ Y HRLIDD VAQ++K +GGFVWACKNYDGDVQSDI+AQGFGSLGLMTSVL+CPDGKTI
Sbjct: 283 IWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTI 342
Query: 330 ESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLERAT 389
E+EAAHGTVTRHYREHQKG+ TSTN +ASIFAWTRGL HRGKLDGN L+ FA LE+
Sbjct: 343 EAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQMLEKVC 402
Query: 390 IKTIEGGHMTKDLALCVHGAAALQ-RSHYETTEVFIDSVAEELARSV 435
++T+E G MTKDLA C+HG + ++ H+ T F+D++ L R++
Sbjct: 403 VETVESGAMTKDLAGCIHGLSNVKLNEHFLNTMDFLDTIKSNLDRAL 449
>ref|NP_001004799.1| MGC69505 protein [Xenopus tropicalis]
gb|AAH74545.1| MGC69505 protein [Xenopus tropicalis]
Length = 455
Score = 566 bits (1458), Expect = e-159, Method: Composition-based stats.
Identities = 266/440 (60%), Positives = 331/440 (75%), Gaps = 8/440 (1%)
Query: 4 RVACAASSVNAGALTPRFVSTTRPSL-----GRIKVSGTVVDMDGDEMTRIIWALIKEKL 58
R + AA N G L P RIKV+ VV+MDGDEMTRIIW IKEKL
Sbjct: 13 RASAAALGKNPGVLAPALSQQQLQQQRNYADKRIKVANPVVEMDGDEMTRIIWEFIKEKL 72
Query: 59 ILPHVDVPIEYYDLSITSRDASNDKVTEQAAEAIQRHNVGIKCATITPDEARVKEFNLKK 118
IL +VDV ++Y+DL + RD +ND+VT +A A ++NV +KCATITPDEARV+EF LKK
Sbjct: 73 ILSNVDVELKYFDLGLPYRDQTNDQVTIDSALATLKYNVAVKCATITPDEARVEEFKLKK 132
Query: 119 MWKSPNGTIRNILGGTVFREPIIVKNVPRVVPQWSEPIIVGRHAYGDQYKATESLF-PPG 177
MWKSPNGTIRNILGGTVFR+PII KN+PR+VP W++ I +GRHA+GDQYKAT+ + G
Sbjct: 133 MWKSPNGTIRNILGGTVFRDPIICKNIPRLVPGWTQAITIGRHAHGDQYKATDFVVDQAG 192
Query: 178 RLELVHTPANGGSPQVLEVFNFKGEGVGLAMYNTRESVEAFAESCFEYAIMRRYPLVLST 237
+LV PANG + + EVFNF GVG+ MYNT ES+ FA SCF+Y+I +++PL LST
Sbjct: 193 TFKLVFAPANGTATKEWEVFNFPAGGVGMGMYNTDESISGFAHSCFQYSIQKKWPLYLST 252
Query: 238 KNTILKKYDGLFLETFQRMYDTKYREQFERLNLTYVHRLIDDQVAQMIKGNGGFVWACKN 297
KNTILK YDG F + FQ +++ Y+ +F++L + Y HRLIDD VAQ++K GGFVWACKN
Sbjct: 253 KNTILKAYDGRFKDIFQDIFEKHYKPEFDKLKIWYEHRLIDDMVAQVLKSTGGFVWACKN 312
Query: 298 YDGDVQSDIVAQGFGSLGLMTSVLLCPDGKTIESEAAHGTVTRHYREHQKGKETSTNSVA 357
YDGDVQSDI+AQGFGSLGLMTSVL+CPDGKTIE+EAAHGTVTRHYREHQKG+ TSTN +A
Sbjct: 313 YDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIA 372
Query: 358 SIFAWTRGLAHRGKLDGNAPLVEFASSLERATIKTIEGGHMTKDLALCVHGAAALQR--S 415
SIFAWTRGL HRGKLDGN L+ F+ +LE+ ++T+E G MTKDLA C+HG + R
Sbjct: 373 SIFAWTRGLEHRGKLDGNQDLINFSLTLEKVCVETVESGIMTKDLAGCIHGGMSNVRLNE 432
Query: 416 HYETTEVFIDSVAEELARSV 435
HY T F+D++ L +++
Sbjct: 433 HYVNTTDFLDAIKNNLDKAL 452
>gb|ABE98244.1| mitochondrial isocitrate dehydrogenase 2-like [Oreochromis
mossambicus]
Length = 452
Score = 565 bits (1457), Expect = e-159, Method: Composition-based stats.
Identities = 262/438 (59%), Positives = 339/438 (77%), Gaps = 6/438 (1%)
Query: 4 RVACAASSVNAGALTP----RFVSTTRPSLGRIKVSGTVVDMDGDEMTRIIWALIKEKLI 59
R A AA S N L P + + + RIKV+ VV+MDGDEMTRIIW IKEKLI
Sbjct: 13 RSAGAAFSRNPAVLAPAANCQTLQQRNYADKRIKVANPVVEMDGDEMTRIIWEFIKEKLI 72
Query: 60 LPHVDVPIEYYDLSITSRDASNDKVTEQAAEAIQRHNVGIKCATITPDEARVKEFNLKKM 119
L +VDV ++Y+DL + RD ++D+VT +A A ++++V +KCATITPDEARV+EF LKKM
Sbjct: 73 LTNVDVELKYFDLGLPYRDQTDDQVTIDSALATKKYSVAVKCATITPDEARVEEFGLKKM 132
Query: 120 WKSPNGTIRNILGGTVFREPIIVKNVPRVVPQWSEPIIVGRHAYGDQYKATESLF-PPGR 178
WKSPNGTIRNILGGTVFREPII KN+PR+VP W++PI +GRHA+GDQY+AT+ + PG+
Sbjct: 133 WKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTQPITIGRHAFGDQYRATDFVVDQPGK 192
Query: 179 LELVHTPANGGSPQVLEVFNFKGEGVGLAMYNTRESVEAFAESCFEYAIMRRYPLVLSTK 238
++V +PA+G + + EVF+F G G+ MYNT ES+ FA SCF+YAI +++PL +STK
Sbjct: 193 FKIVFSPADGSTSKEWEVFDFPAGGCGMGMYNTDESITGFAHSCFQYAIGKKWPLYMSTK 252
Query: 239 NTILKKYDGLFLETFQRMYDTKYREQFERLNLTYVHRLIDDQVAQMIKGNGGFVWACKNY 298
NTILK YDG F + FQ +++ Y+ +F++L + Y HRLIDD VAQ++K +G FVWACKNY
Sbjct: 253 NTILKAYDGRFKDIFQDIFEKNYKPEFDKLKIWYEHRLIDDMVAQVLKSSGAFVWACKNY 312
Query: 299 DGDVQSDIVAQGFGSLGLMTSVLLCPDGKTIESEAAHGTVTRHYREHQKGKETSTNSVAS 358
DGDVQSDI+AQGFGSLGLMTSVL+CPDGKTIE+EAAHGTVTRHYREHQKG+ TSTN +AS
Sbjct: 313 DGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIAS 372
Query: 359 IFAWTRGLAHRGKLDGNAPLVEFASSLERATIKTIEGGHMTKDLALCVHGAAALQ-RSHY 417
IFAWTRGL HRGKLDGN L++FA +LE+ + T+E G MTKDLA C+HG + ++ HY
Sbjct: 373 IFAWTRGLEHRGKLDGNPDLIKFAQTLEQVCVATVESGTMTKDLAGCIHGLSNVKLNEHY 432
Query: 418 ETTEVFIDSVAEELARSV 435
T F+D++ L +++
Sbjct: 433 VNTTDFLDAIKTNLDKAL 450
>dbj|BAD96636.1| isocitrate dehydrogenase 2 (NADP+), mitochondrial precursor variant
[Homo sapiens]
Length = 452
Score = 565 bits (1457), Expect = e-159, Method: Composition-based stats.
Identities = 258/407 (63%), Positives = 324/407 (79%), Gaps = 2/407 (0%)
Query: 31 RIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQAAE 90
RIKV+ VV+MDGDEMTRIIW IKEKLILPHVD+ ++Y+DL + +RD ++D+VT +A
Sbjct: 43 RIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSAL 102
Query: 91 AIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRVVP 150
A Q+++V +KCATITPDEARV+EF LKKMWKSPNGTIRNILGGTVFREPII KN+PR+VP
Sbjct: 103 ATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVP 162
Query: 151 QWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNFKGEGVGLAMY 209
W++PI +GRHA+GDQYKAT+ + G ++V TP +G + EV+NF GVG+ MY
Sbjct: 163 GWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMY 222
Query: 210 NTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFERLN 269
NT ES+ FA SCF+YAI +++PL +STKNTILK YDG F + FQ ++D Y F++
Sbjct: 223 NTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYETDFDKNK 282
Query: 270 LTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDGKTI 329
+ Y HRLIDD VAQ++K +GGFVWACKNYDGDVQSDI+AQGFGSLGLMTSVL+CPDGKTI
Sbjct: 283 IWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTI 342
Query: 330 ESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLERAT 389
E+EAAHGTVTRHYREHQKG+ TSTN +ASIFAWTRGL HRGKLDGN L+ FA LE+
Sbjct: 343 EAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQMLEKVC 402
Query: 390 IKTIEGGHMTKDLALCVHGAAALQ-RSHYETTEVFIDSVAEELARSV 435
++T+E G MTKDLA C+HG + ++ H+ T F+D++ L R++
Sbjct: 403 VETVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRAL 449
>ref|NP_955858.1| isocitrate dehydrogenase 2 (NADP+), mitochondrial [Danio rerio]
gb|AAH48041.1| Isocitrate dehydrogenase 2 (NADP+), mitochondrial [Danio rerio]
gb|AAH63967.1| Isocitrate dehydrogenase 2 (NADP+), mitochondrial [Danio rerio]
Length = 449
Score = 565 bits (1457), Expect = e-159, Method: Composition-based stats.
Identities = 256/407 (62%), Positives = 327/407 (80%), Gaps = 2/407 (0%)
Query: 31 RIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQAAE 90
RI+V+ VV+MDGDEMTRIIW IKEKLIL +V+V ++YYDL + RD ++D+VT +A
Sbjct: 41 RIQVAQPVVEMDGDEMTRIIWEFIKEKLILTNVNVDLKYYDLGLPYRDQTDDQVTIDSAI 100
Query: 91 AIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRVVP 150
A +++NV +KCATITPDEARV+EF LKKMWKSPNGTIRNILGGTVFREPII KN+PR+VP
Sbjct: 101 ATKKYNVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVP 160
Query: 151 QWSEPIIVGRHAYGDQYKATESLF-PPGRLELVHTPANGGSPQVLEVFNFKGEGVGLAMY 209
W++ I +GRHA+GDQYKAT+ + PG+ ++V TPA+G + EV++F G G G+ MY
Sbjct: 161 GWTQAITIGRHAFGDQYKATDFVVNQPGKFKMVFTPADGSKNKEWEVYDFPGGGCGMGMY 220
Query: 210 NTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFERLN 269
NT ES+ FA SCF+YAI +++PL +STKNTILK YDG F + FQ +++ Y+ +F++L
Sbjct: 221 NTDESITGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQDIFEKNYKPEFDKLK 280
Query: 270 LTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDGKTI 329
+ Y HRLIDD VAQ++K +G FVWACKNYDGDVQSDI+AQGFGSLGLMTSVL+CPDGKTI
Sbjct: 281 IWYEHRLIDDMVAQVLKSSGAFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTI 340
Query: 330 ESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLERAT 389
E+EAAHGTVTRHYREHQKG+ TSTN +ASIFAWTRGL HRGKLDGN L++F+ +LER
Sbjct: 341 EAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNPDLIKFSQTLERVC 400
Query: 390 IKTIEGGHMTKDLALCVHGAAALQ-RSHYETTEVFIDSVAEELARSV 435
++T+E G MTKDLA C+HG A + HY T F+D++ L +++
Sbjct: 401 VETVESGVMTKDLAGCIHGLANCKLNEHYVNTTDFLDAIKTNLDKAL 447
>ref|XP_821599.1| isocitrate dehydrogenase, putative [Trypanosoma cruzi strain CL
Brener]
gb|EAN99748.1| isocitrate dehydrogenase, putative [Trypanosoma cruzi]
Length = 413
Score = 565 bits (1456), Expect = e-159, Method: Composition-based stats.
Identities = 258/407 (63%), Positives = 325/407 (79%), Gaps = 1/407 (0%)
Query: 29 LGRIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQA 88
+ +IKV+GTVV++DGDEMTR+IW +IKE+LI P +DVPIEYYDL + +RD ++D+VT A
Sbjct: 1 MQKIKVAGTVVELDGDEMTRVIWKMIKEELIFPFLDVPIEYYDLGMENRDKTDDQVTVDA 60
Query: 89 AEAIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRV 148
A AI++H VG+KCATITPDEARV+EFNLK+MWKSPNGTIRNILGGTVFREPI+ KNVPR+
Sbjct: 61 AHAIKKHGVGVKCATITPDEARVREFNLKQMWKSPNGTIRNILGGTVFREPIMCKNVPRL 120
Query: 149 VPQWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNFKGEGVGLA 207
V W PI++GRHA+GDQY+AT+ + PG E+ P +GG+ QV +VF+FK GV +
Sbjct: 121 VTTWKHPIVIGRHAFGDQYRATDLVVNGPGTFEIHFVPESGGAAQVQKVFDFKSGGVLMG 180
Query: 208 MYNTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFER 267
MYNT ES++ FA+SCFEYA+ +++PL LSTKNTILK+YDG F + F MY Y +++
Sbjct: 181 MYNTDESIKDFAKSCFEYALSKKWPLYLSTKNTILKRYDGRFKDIFAEMYKASYEADYKK 240
Query: 268 LNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDGK 327
+ Y HRLIDD VA +K GG+VWACKNYDGDVQSD VAQGFGSLGLMTSVL+ PDG+
Sbjct: 241 AGIWYEHRLIDDMVAYAMKSEGGYVWACKNYDGDVQSDSVAQGFGSLGLMTSVLMSPDGR 300
Query: 328 TIESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLER 387
T+E+EAAHGTVTRHYR+HQKG+ETSTN VASIFAWTRGL HRGKLD N LV+F+ LE+
Sbjct: 301 TVEAEAAHGTVTRHYRQHQKGEETSTNPVASIFAWTRGLMHRGKLDQNEKLVQFSMLLEK 360
Query: 388 ATIKTIEGGHMTKDLALCVHGAAALQRSHYETTEVFIDSVAEELARS 434
+ TIE G MTKDLA+C+ G + RS Y T+ FI +A+E+ ++
Sbjct: 361 VVVSTIEAGFMTKDLAICIKGMNHVTRSDYLNTQEFIHKLADEMRKA 407
>gb|ABO93633.1| isocitrate dehydrogenase 2 [Toxoplasma gondii]
Length = 621
Score = 564 bits (1454), Expect = e-159, Method: Composition-based stats.
Identities = 273/431 (63%), Positives = 331/431 (76%), Gaps = 13/431 (3%)
Query: 3 RRVACAASSVNAGALTPRFVSTTRPSLGRIKVSGTVVDMDGDEMTRIIWALIKEKLILPH 62
R A AAS GA G+I V+ VV+MDGDEMTRI+WA IKEKL+ P+
Sbjct: 156 RFFASAASVATGGAFNLE---------GKIHVANPVVEMDGDEMTRILWAWIKEKLLFPY 206
Query: 63 VDVPIEYYDLSITSRDASNDKVTEQAAEAIQRHNVGIKCATITPDEARVKEFNLKKMWKS 122
V++P+EYYDLS+T+RD + DKVT +AAEAI++ +VGIKCATITPDE RVKEFNLKKMWKS
Sbjct: 207 VEIPLEYYDLSVTNRDQTEDKVTLEAAEAIKKCHVGIKCATITPDEGRVKEFNLKKMWKS 266
Query: 123 PNGTIRNILGGTVFREPIIVKNVPRVVPQWSEPIIVGRHAYGDQYKATESLF--PPGRLE 180
PNGTIRNIL GTVFR PI++ NVPR+VP W +PI++GRHAYGDQYKA ESL PG
Sbjct: 267 PNGTIRNILDGTVFRAPILISNVPRLVPGWKKPIVIGRHAYGDQYKA-ESLVCDGPGDFT 325
Query: 181 LVHTPANGGSPQVLEVFNFKGEGVGLAMYNTRESVEAFAESCFEYAIMRRYPLVLSTKNT 240
+ TPA GGS +VF+F G GV L MYNT +S+ FA S F++A+ + PL LSTKNT
Sbjct: 326 ISFTPA-GGSRVEKKVFSFSGPGVMLGMYNTEDSIRGFALSSFKFALQQNMPLYLSTKNT 384
Query: 241 ILKKYDGLFLETFQRMYDTKYREQFERLNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDG 300
ILK+YDG+F + FQ YD +++ FE+ + Y HRLIDD VAQ +K GGFVWACKNYDG
Sbjct: 385 ILKQYDGMFKDIFQSYYDEQFKPLFEKQGIWYEHRLIDDMVAQALKSEGGFVWACKNYDG 444
Query: 301 DVQSDIVAQGFGSLGLMTSVLLCPDGKTIESEAAHGTVTRHYREHQKGKETSTNSVASIF 360
DVQSDIVAQG+GSLGLMTS+L+CPDGKT+ SEAAHGTVTRHYR+HQKG++TSTN +ASIF
Sbjct: 445 DVQSDIVAQGYGSLGLMTSILVCPDGKTVVSEAAHGTVTRHYRQHQKGQKTSTNPIASIF 504
Query: 361 AWTRGLAHRGKLDGNAPLVEFASSLERATIKTIEGGHMTKDLALCVHGAAALQRSHYETT 420
AWTRGLAHR KLDGN L +F +LE A I+T+E G M KDLALCV GA + S Y TT
Sbjct: 505 AWTRGLAHRAKLDGNDRLGQFCLALEHACIQTVENGAMPKDLALCVKGADKVTASDYLTT 564
Query: 421 EVFIDSVAEEL 431
E F+D++++ L
Sbjct: 565 EEFMDAISDTL 575
>emb|CAG02362.1| unnamed protein product [Tetraodon nigroviridis]
Length = 438
Score = 564 bits (1454), Expect = e-159, Method: Composition-based stats.
Identities = 261/433 (60%), Positives = 328/433 (75%), Gaps = 28/433 (6%)
Query: 31 RIKVSGTVVDMDGDEMTRIIWALIKEK--------------------------LILPHVD 64
RIKV VV+MDGDEMTRIIW IKEK LILP+VD
Sbjct: 4 RIKVEQPVVEMDGDEMTRIIWEFIKEKVLKSSKRCRFFGGPAWFFPSPCVRPQLILPNVD 63
Query: 65 VPIEYYDLSITSRDASNDKVTEQAAEAIQRHNVGIKCATITPDEARVKEFNLKKMWKSPN 124
V ++Y+DL + RD ++D+VT +A A +++NV +KCATITPDEARV+EFNLKKMWKSPN
Sbjct: 64 VELKYFDLGLPYRDQTDDQVTIDSALATKKYNVAVKCATITPDEARVEEFNLKKMWKSPN 123
Query: 125 GTIRNILGGTVFREPIIVKNVPRVVPQWSEPIIVGRHAYGDQYKATE-SLFPPGRLELVH 183
GTIRNILGGTVFREPI+ KN+PR+VP W++PI +GRHA+GDQY+AT+ ++ PG+ +++
Sbjct: 124 GTIRNILGGTVFREPILCKNIPRLVPGWTQPITIGRHAFGDQYRATDFTVNQPGKFKIIF 183
Query: 184 TPANGGSPQVLEVFNFKGEGVGLAMYNTRESVEAFAESCFEYAIMRRYPLVLSTKNTILK 243
PA+GG + EV++FK G G+ MYNT ES+ FA SCF+YAI +++PL +STKNTILK
Sbjct: 184 APADGGQQKEWEVYDFKSGGCGMGMYNTDESIWGFAHSCFQYAIQKKWPLYMSTKNTILK 243
Query: 244 KYDGLFLETFQRMYDTKYREQFERLNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQ 303
YDG F + FQ +Y+ Y+ +FE+L + Y HRLIDD VAQ++K +G FVWACKNYDGDVQ
Sbjct: 244 AYDGRFKDIFQDIYEKDYQAEFEKLKIWYEHRLIDDMVAQVLKSSGAFVWACKNYDGDVQ 303
Query: 304 SDIVAQGFGSLGLMTSVLLCPDGKTIESEAAHGTVTRHYREHQKGKETSTNSVASIFAWT 363
SDI+AQGFGSLGLMTSVL+CPDGKTIE+EAAHGTVTRHYREHQ+GK TSTN +ASIFAWT
Sbjct: 304 SDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQRGKPTSTNPIASIFAWT 363
Query: 364 RGLAHRGKLDGNAPLVEFASSLERATIKTIEGGHMTKDLALCVHGAAALQ-RSHYETTEV 422
RGL HRGKLDGN L+ F +LER ++T+E G MTKDLA C+HG A + HY T
Sbjct: 364 RGLEHRGKLDGNPDLIRFCQTLERVCVETVESGVMTKDLAGCIHGLANCKLNEHYVNTTD 423
Query: 423 FIDSVAEELARSV 435
F+D++ L RS+
Sbjct: 424 FLDAIRTNLDRSL 436
>gb|AAC52473.1| isocitrate dehydrogenase
Length = 523
Score = 561 bits (1446), Expect = e-158, Method: Composition-based stats.
Identities = 259/407 (63%), Positives = 322/407 (79%), Gaps = 3/407 (0%)
Query: 31 RIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQAAE 90
RIKV VV+MDGDEMTRIIW IKEKLILPHVDV ++Y+DL + +RD +ND+VT +A
Sbjct: 115 RIKVEKPVVEMDGDEMTRIIWQFIKEKLILPHVDVQLKYFDLGLPNRDQTNDQVTIDSAL 174
Query: 91 AIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRVVP 150
A Q++++ +KCATITPDEARV+EF LKKMWKSPNGTIRNILGGTVFREP I KN+PR+VP
Sbjct: 175 AAQKYSMAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPSICKNIPRLVP 234
Query: 151 QWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNFKGEGVGLAMY 209
W++PI +GRHA+GDQYKAT+ + G +LV TP NG S + EV+NF G GVG+ MY
Sbjct: 235 GWTKPITIGRHAHGDQYKATDFVVDRAGTFKLVFTPKNGSSAKEWEVYNFPGGGVGMGMY 294
Query: 210 NTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFERLN 269
NT ES+ FA SCF+Y+I +++PL LSTKNTILK YDG F + FQ ++D Y+ F+R
Sbjct: 295 NTDESISGFAHSCFQYSIQKKWPLYLSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDRNK 354
Query: 270 LTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDGKTI 329
+ Y HRLIDD VAQ++K +GGFVWACKNYDGDVQSDI+A FGSLGLMTSVL+CPDGKTI
Sbjct: 355 IWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILASRFGSLGLMTSVLVCPDGKTI 414
Query: 330 ESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLERAT 389
E+EAAHGTVTRHYREHQKG+ TST +ASIFAWTRGL HRGKLDGN L+ FA + E+
Sbjct: 415 EAEAAHGTVTRHYREHQKGRPTSTKGIASIFAWTRGLEHRGKLDGNQDLIRFAQTREKVC 474
Query: 390 IKTIEGGHMTKDLALCVHGAAALQ-RSHYETTEVFIDSVAEELARSV 435
++T+EG MTKDLA C+HG + ++ H+ T F+D++ L R++
Sbjct: 475 VQTVEGA-MTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRAL 520
>prf||2211361A isocitrate dehydrogenase
Length = 523
Score = 561 bits (1446), Expect = e-158, Method: Composition-based stats.
Identities = 259/407 (63%), Positives = 322/407 (79%), Gaps = 3/407 (0%)
Query: 31 RIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQAAE 90
RIKV VV+MDGDEMTRIIW IKEKLILPHVDV ++Y+DL + +RD +ND+VT +A
Sbjct: 115 RIKVEKPVVEMDGDEMTRIIWQFIKEKLILPHVDVQLKYFDLGLPNRDQTNDQVTIDSAL 174
Query: 91 AIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRVVP 150
A Q++++ +KCATITPDEARV+EF LKKMWKSPNGTIRNILGGTVFREP I KN+PR+VP
Sbjct: 175 AAQKYSMAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPSICKNIPRLVP 234
Query: 151 QWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNFKGEGVGLAMY 209
W++PI +GRHA+GDQYKAT+ + G +LV TP NG S + EV+NF G GVG+ MY
Sbjct: 235 GWTKPITIGRHAHGDQYKATDFVVDRAGTFKLVFTPKNGSSAKEWEVYNFPGGGVGMGMY 294
Query: 210 NTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFERLN 269
NT ES+ FA SCF+Y+I +++PL LSTKNTILK YDG F + FQ ++D Y+ F+R
Sbjct: 295 NTDESISGFAHSCFQYSIQKKWPLYLSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDRNK 354
Query: 270 LTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDGKTI 329
+ Y HRLIDD VAQ++K +GGFVWACKNYDGDVQSDI+A FGSLGLMTSVL+CPDGKTI
Sbjct: 355 IWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILASRFGSLGLMTSVLVCPDGKTI 414
Query: 330 ESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLERAT 389
E+EAAHGTVTRHYREHQKG+ TST +ASIFAWTRGL HRGKLDGN L+ FA + E+
Sbjct: 415 EAEAAHGTVTRHYREHQKGRPTSTKGIASIFAWTRGLEHRGKLDGNQDLIRFAQTREKVC 474
Query: 390 IKTIEGGHMTKDLALCVHGAAALQ-RSHYETTEVFIDSVAEELARSV 435
++T+EG MTKDLA C+HG + ++ H+ T F+D++ L R++
Sbjct: 475 VQTVEGA-MTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRAL 520
>emb|CAG13105.1| unnamed protein product [Tetraodon nigroviridis]
Length = 415
Score = 561 bits (1445), Expect = e-158, Method: Composition-based stats.
Identities = 253/407 (62%), Positives = 328/407 (80%), Gaps = 2/407 (0%)
Query: 31 RIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQAAE 90
RIKV+ VV+MDGDEMTRIIW IKEKLIL +VDV ++Y+DL + RD ++D+VT +A
Sbjct: 7 RIKVAQPVVEMDGDEMTRIIWEFIKEKLILTNVDVELKYFDLGLPYRDQTDDQVTIDSAL 66
Query: 91 AIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRVVP 150
A ++++V +KCATITPDEARV+EF LKKMWKSPNGTIRNILGGTVFREPII +N+PR+VP
Sbjct: 67 ATKKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICRNIPRLVP 126
Query: 151 QWSEPIIVGRHAYGDQYKATESLF-PPGRLELVHTPANGGSPQVLEVFNFKGEGVGLAMY 209
W++PI +GRHA+GDQY+AT+ + PG+ ++V +PA+G S + EV++F G G+ MY
Sbjct: 127 GWTQPITIGRHAFGDQYRATDFVVDKPGKFKIVFSPADGSSAKEWEVYDFPAGGCGMGMY 186
Query: 210 NTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFERLN 269
NT ES+ FA SCF+YAI +++PL +STKNTILK YDG F + FQ +++ Y+ +F++L
Sbjct: 187 NTDESITGFAHSCFQYAIGKKWPLYMSTKNTILKAYDGRFKDIFQDIFEKHYKPEFDKLK 246
Query: 270 LTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDGKTI 329
+ Y HRLIDD VAQ++K +G FVWACKNYDGDVQSDI+AQGFGSLGLMTSVL+CPDGKTI
Sbjct: 247 IWYEHRLIDDMVAQVLKSSGAFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTI 306
Query: 330 ESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLERAT 389
E+EAAHGTVTRHYREHQKG+ TSTN +ASIFAWTRGL HRGKLDGN L++F+ +LER
Sbjct: 307 EAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNNDLIKFSQTLERVC 366
Query: 390 IKTIEGGHMTKDLALCVHGAAALQ-RSHYETTEVFIDSVAEELARSV 435
++T+E G MTKDLA C+HG ++ HY T F+D++ L +++
Sbjct: 367 VETVESGTMTKDLAGCIHGLPNVKLNEHYVNTTDFLDAIRTNLDKAL 413
>ref|XP_001778805.1| predicted protein [Physcomitrella patens subsp. patens]
gb|EDQ56391.1| predicted protein [Physcomitrella patens subsp. patens]
Length = 411
Score = 560 bits (1443), Expect = e-158, Method: Composition-based stats.
Identities = 260/407 (63%), Positives = 329/407 (80%), Gaps = 4/407 (0%)
Query: 28 SLGRIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQ 87
+ +I V+ +V+MDGDEMTRIIW +IK+KLI P +D+ ++Y+DL I RDA++D+VT +
Sbjct: 2 AFAKIHVANPIVEMDGDEMTRIIWKMIKDKLIFPFLDLDLKYFDLGIEHRDATDDRVTIE 61
Query: 88 AAEAIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPR 147
+AEA +++NV +KCATITPDEARVKE+NLK MW+SPNGTIRNIL GTVFREPI+ KN+P+
Sbjct: 62 SAEATKKYNVAVKCATITPDEARVKEYNLKSMWRSPNGTIRNILNGTVFREPILCKNIPK 121
Query: 148 VVPQWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNFKGEG-VG 205
+VP W+ PI +GRHA+GDQYKAT+++F PG+L++V P NGG Q L V++F+G G V
Sbjct: 122 LVPGWTSPICIGRHAFGDQYKATDAVFKGPGKLKMVFVPENGGETQDLTVYDFEGAGGVA 181
Query: 206 LAMYNTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTK-YREQ 264
L MYNT ES+ +FAES A +++PL LSTKNTILKKYDG F + FQ +Y+ + ++ +
Sbjct: 182 LTMYNTDESIRSFAESSMAMAYEKKWPLYLSTKNTILKKYDGRFKDIFQEVYEQEGWKAK 241
Query: 265 FERLNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCP 324
F+ + Y HRLIDD VA +K GG+VWACKNYDGDVQSD++AQGFGSLGLMTSVL+CP
Sbjct: 242 FDAAGIWYEHRLIDDMVAYALKSEGGYVWACKNYDGDVQSDMLAQGFGSLGLMTSVLVCP 301
Query: 325 DGKTIESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASS 384
DGKTIE+EAAHGTVTRHYR HQKG ETSTNS+ASIFAWTRGL+HRGKLDGN LV+FA+
Sbjct: 302 DGKTIEAEAAHGTVTRHYRVHQKGGETSTNSIASIFAWTRGLSHRGKLDGNEKLVDFATK 361
Query: 385 LERATIKTIEGGHMTKDLALCVHGAAALQRSHYETTEVFIDSVAEEL 431
LE+A + T+E G MTKDLAL +HG + L R Y TE FID+VAEEL
Sbjct: 362 LEQACVGTVENGKMTKDLALLIHG-SKLSRDTYLNTEEFIDAVAEEL 407
>ref|ZP_01885694.1| isocitrate dehydrogenase [Pedobacter sp. BAL39]
gb|EDM34991.1| isocitrate dehydrogenase [Pedobacter sp. BAL39]
Length = 411
Score = 560 bits (1442), Expect = e-157, Method: Composition-based stats.
Identities = 256/405 (63%), Positives = 318/405 (78%), Gaps = 1/405 (0%)
Query: 28 SLGRIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQ 87
S+ +IKV VV++DGDEMTRIIW IK+KLILP++D+ I+YYDL + RD +ND+VT
Sbjct: 2 SVQKIKVDQPVVELDGDEMTRIIWKFIKDKLILPYLDLDIKYYDLGVEYRDETNDQVTID 61
Query: 88 AAEAIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPR 147
AAEAI+++ VGIKCATITPDE RVKEFNLK+MWKSPNGTIRNIL GTVFREPI++ NVPR
Sbjct: 62 AAEAIKQYGVGIKCATITPDEERVKEFNLKQMWKSPNGTIRNILDGTVFREPIVMSNVPR 121
Query: 148 VVPQWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNFKGEGVGL 206
+VP W+ PI +GRHA+GDQY+AT+ + G+L L TP +GG Q +V+NFKG+GV L
Sbjct: 122 LVPNWTAPICIGRHAFGDQYRATDLVTKGKGKLTLTFTPEDGGEVQSFDVYNFKGDGVAL 181
Query: 207 AMYNTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFE 266
AMYNT ES+ FA +CF A+++++PL LSTKNTILKKYDG F + FQ +Y+ ++ +F+
Sbjct: 182 AMYNTDESIRGFANACFNQALIKKWPLYLSTKNTILKKYDGRFKDIFQEIYENDFKAKFD 241
Query: 267 RLNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDG 326
+TY HRLIDD VA +K NG FVWACKNYDGDVQSD VAQGFGSLGLMTSVL+ PDG
Sbjct: 242 EAGITYEHRLIDDMVASALKWNGNFVWACKNYDGDVQSDTVAQGFGSLGLMTSVLVTPDG 301
Query: 327 KTIESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLE 386
KT+E+EAAHGTVTRHYR+HQ GK TSTN +ASIFAWTRGL RG LD N L++F +LE
Sbjct: 302 KTMEAEAAHGTVTRHYRDHQAGKPTSTNPIASIFAWTRGLEFRGVLDNNQELIKFCQALE 361
Query: 387 RATIKTIEGGHMTKDLALCVHGAAALQRSHYETTEVFIDSVAEEL 431
+ I+T+E G MTKDLA+C+HG HY TE F+ ++ E L
Sbjct: 362 QVCIETVESGKMTKDLAVCIHGNKVEHGKHYLYTEEFLAAIDENL 406
>ref|NP_970434.1| isocitrate dehydrogenase [Bdellovibrio bacteriovorus HD100]
emb|CAE81088.1| isocitrate dehydrogenase (NADP) [Bdellovibrio bacteriovorus HD100]
Length = 409
Score = 560 bits (1442), Expect = e-157, Method: Composition-based stats.
Identities = 258/408 (63%), Positives = 322/408 (78%), Gaps = 2/408 (0%)
Query: 29 LGRIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQA 88
+ +IKV+ VV++DGDEMTRIIW IK++LILP++D+ I+YYDL + RDA+ND+VT A
Sbjct: 1 MKKIKVANPVVELDGDEMTRIIWKFIKQQLILPYLDIDIKYYDLGMEHRDATNDQVTVDA 60
Query: 89 AEAIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRV 148
AEAI+++NVGIKCATITPDEARVKEFNLK+MWKSPNGTIRNIL GTVFREPII KNVPR+
Sbjct: 61 AEAIKKYNVGIKCATITPDEARVKEFNLKQMWKSPNGTIRNILDGTVFREPIICKNVPRL 120
Query: 149 VPQWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNFKGEGVGLA 207
VP W+ PI +GRHA+GDQY+AT+ + G+L + P NGG EV+NFKG+GV L
Sbjct: 121 VPNWTAPICIGRHAFGDQYRATDFVTKGKGKLTVTFQPENGGETITHEVYNFKGDGVALT 180
Query: 208 MYNTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFER 267
MYNT ES+ FA SCF A+ +++PL LSTKNTILKKYDG F + F+ +Y +++ +F+
Sbjct: 181 MYNTDESITGFARSCFNQALTKKWPLYLSTKNTILKKYDGRFKDIFEEIYQKEFKAKFDA 240
Query: 268 LNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDGK 327
+TY HRLIDD VA +K NG FVWACKNYDGDVQSD VAQGFGSLGLMTSVL+ PDGK
Sbjct: 241 AGITYEHRLIDDMVASALKWNGNFVWACKNYDGDVQSDTVAQGFGSLGLMTSVLVTPDGK 300
Query: 328 TIESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLER 387
T+ESEAAHGTVTRHYR+HQ+GK TSTN +ASIFAWTRGL HRG LD N LV+FA +LE+
Sbjct: 301 TMESEAAHGTVTRHYRQHQQGKPTSTNPIASIFAWTRGLEHRGNLDNNQELVKFAQTLEK 360
Query: 388 ATIKTIEGGHMTKDLALCVHGAAALQRSHYETTEVFIDSVAEELARSV 435
++T+E G MTKDLA+C++G + Y TE F+ + E L +++
Sbjct: 361 VCVETVEAGFMTKDLAVCIYG-DKVPADKYMNTEPFLAKLDENLKKAL 407
>ref|XP_001426548.1| hypothetical protein GSPATT00029781001 [Paramecium tetraurelia
strain d4-2]
emb|CAK59150.1| unnamed protein product [Paramecium tetraurelia]
Length = 411
Score = 559 bits (1441), Expect = e-157, Method: Composition-based stats.
Identities = 264/404 (65%), Positives = 317/404 (78%), Gaps = 3/404 (0%)
Query: 30 GRIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQAA 89
+IKV+ VV+MDGDEMTR+IWA IKE LI P +D+PI+YYDL + +RD ++DKVT + A
Sbjct: 3 AKIKVNNPVVEMDGDEMTRVIWAWIKEYLITPFLDIPIKYYDLGMENRDQTDDKVTIECA 62
Query: 90 EAIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRVV 149
+AIQ VGIKCATITPDEARVKEFNLK MWKSPNGTIRNIL GTVFREPI++KN+PR+V
Sbjct: 63 KAIQECKVGIKCATITPDEARVKEFNLKYMWKSPNGTIRNILNGTVFREPILIKNIPRLV 122
Query: 150 PQWSEPIIVGRHAYGDQYKATESLF-PPGRLELVHTPANGGSPQVLEVFNFKGE-GVGLA 207
P W++PI++GRHA+GDQYKAT+ F G+ E++ TP +G PQ +EVF+F+G GV +A
Sbjct: 123 PGWTKPIVIGRHAFGDQYKATDLRFQKEGKFEVLFTPKDGSEPQRVEVFDFQGTGGVAMA 182
Query: 208 MYNTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFER 267
MYNT ES+ AFA +CF++AI YPL LSTKNTILK YDG F + FQ +YDTKY+ FE
Sbjct: 183 MYNTDESITAFAHACFQHAIELAYPLYLSTKNTILKVYDGRFKDIFQHLYDTKYKADFEA 242
Query: 268 LNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDGK 327
+ Y HRLIDD VA MIK GGFVWACKNYDGDVQSD +AQGFGSLGLMTSVL+ PDG
Sbjct: 243 KKIWYEHRLIDDMVAYMIKSEGGFVWACKNYDGDVQSDTLAQGFGSLGLMTSVLVSPDG- 301
Query: 328 TIESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLER 387
+E+EAAHGTVTRHYR HQ+GKETSTNS+ASI+AWTRGL HR KLD N L F ++LE
Sbjct: 302 CVEAEAAHGTVTRHYRLHQQGKETSTNSIASIYAWTRGLLHRAKLDNNKELERFCNTLEA 361
Query: 388 ATIKTIEGGHMTKDLALCVHGAAALQRSHYETTEVFIDSVAEEL 431
+ I+ +E G MTKDLA+CVH + R Y T FI VAE L
Sbjct: 362 SIIEAVEKGFMTKDLAICVHNTLNVPRDQYLNTLEFIQKVAEVL 405
>ref|NP_001080321.1| hypothetical protein LOC380013 [Xenopus laevis]
gb|AAH54241.1| MGC64442 protein [Xenopus laevis]
Length = 454
Score = 559 bits (1441), Expect = e-157, Method: Composition-based stats.
Identities = 261/439 (59%), Positives = 330/439 (75%), Gaps = 7/439 (1%)
Query: 4 RVACAASSVNAGALTPRFVSTTRPSLG----RIKVSGTVVDMDGDEMTRIIWALIKEKLI 59
R + A N G L P + RIKV+ VV+MDGDEMTRIIW IKEKLI
Sbjct: 13 RASATALGKNPGVLAPALSQQLQQQRNYADKRIKVANPVVEMDGDEMTRIIWEFIKEKLI 72
Query: 60 LPHVDVPIEYYDLSITSRDASNDKVTEQAAEAIQRHNVGIKCATITPDEARVKEFNLKKM 119
L +VDV ++Y+DL + RD ++D+VT +A A ++NV +KCATITPDEARV+EF LKKM
Sbjct: 73 LSNVDVELKYFDLGLPYRDQTDDQVTIDSALATLKYNVAVKCATITPDEARVEEFKLKKM 132
Query: 120 WKSPNGTIRNILGGTVFREPIIVKNVPRVVPQWSEPIIVGRHAYGDQYKATESLF-PPGR 178
WKSPNGT+RNILGGTVFREPII KN+PR+VP W++ I +GRHA+GDQYKAT+ + G
Sbjct: 133 WKSPNGTVRNILGGTVFREPIICKNIPRLVPGWTQAITIGRHAHGDQYKATDFVVDQAGT 192
Query: 179 LELVHTPANGGSPQVLEVFNFKGEGVGLAMYNTRESVEAFAESCFEYAIMRRYPLVLSTK 238
++V TPANG + + EVF F GVG+ MYNT ES+ FA SCF+YAI +++PL +STK
Sbjct: 193 FKMVFTPANGTATKEWEVFKFPAGGVGMGMYNTDESISGFAHSCFQYAIQKKWPLYMSTK 252
Query: 239 NTILKKYDGLFLETFQRMYDTKYREQFERLNLTYVHRLIDDQVAQMIKGNGGFVWACKNY 298
NTILK YDG F + FQ +++ Y+ F+++ + Y HRLIDD VAQ++K +GGFVWACKNY
Sbjct: 253 NTILKAYDGRFKDIFQDIFEKHYKPDFDKVKIWYEHRLIDDMVAQVLKSSGGFVWACKNY 312
Query: 299 DGDVQSDIVAQGFGSLGLMTSVLLCPDGKTIESEAAHGTVTRHYREHQKGKETSTNSVAS 358
DGDVQSDI+AQGFGSLGLM+SVL+CPDGKTIE+EAAHGTVTRHYREHQKG+ TSTN +AS
Sbjct: 313 DGDVQSDILAQGFGSLGLMSSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIAS 372
Query: 359 IFAWTRGLAHRGKLDGNAPLVEFASSLERATIKTIEGGHMTKDLALCVHGAAALQR--SH 416
IFAWTRGL HRGKLDGN L+ F+ LE+ ++T+E G MTKDLA C+HG + R H
Sbjct: 373 IFAWTRGLEHRGKLDGNQDLINFSLKLEKVCVETVESGIMTKDLAGCIHGGMSNVRLNEH 432
Query: 417 YETTEVFIDSVAEELARSV 435
Y T F+D++ L +++
Sbjct: 433 YVNTTDFLDAIKNNLDKAL 451
>ref|NP_010217.1| Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the
oxidation of isocitrate to alpha-ketoglutarate; not
required for mitochondrial respiration and may function
to divert alpha-ketoglutarate to biosynthetic processes;
Idp1p [Saccharomyces cerevisiae]
sp|P21954|IDHP_YEAST Isocitrate dehydrogenase [NADP], mitochondrial precursor
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) (IDP)
gb|AAA34703.1| NADPH-specific isocitrate dehydrogenase
emb|CAA98631.1| IDP1 [Saccharomyces cerevisiae]
gb|EDN60290.1| NADP-dependent isocitrate dehydrogenase [Saccharomyces cerevisiae
YJM789]
Length = 428
Score = 559 bits (1441), Expect = e-157, Method: Composition-based stats.
Identities = 271/425 (63%), Positives = 340/425 (80%), Gaps = 8/425 (1%)
Query: 17 LTPRFVSTTR-PSLGRIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSIT 75
L+ R ST+R + +IKV VV++DGDEMTRIIW IK+KLILP++DV ++YYDLS+
Sbjct: 4 LSRRLFSTSRLAAFSKIKVKQPVVELDGDEMTRIIWDKIKKKLILPYLDVDLKYYDLSVE 63
Query: 76 SRDASNDKVTEQAAEAIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTV 135
SRDA++DK+T+ AAEAI+++ VGIKCATITPDEARVKEFNL KMWKSPNGTIRNILGGTV
Sbjct: 64 SRDATSDKITQDAAEAIKKYGVGIKCATITPDEARVKEFNLHKMWKSPNGTIRNILGGTV 123
Query: 136 FREPIIVKNVPRVVPQWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPAN--GGSPQ 192
FREPI++ +PR+VP+W +PII+GRHA+GDQYKAT++L P PG LELV+ P++ PQ
Sbjct: 124 FREPIVIPRIPRLVPRWEKPIIIGRHAHGDQYKATDTLIPGPGSLELVYKPSDPTTAQPQ 183
Query: 193 VLEVFNFKGEGVGLAMYNTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLET 252
L+V+++KG GV +AMYNT ES+E FA S F+ AI ++ L LSTKNTILKKYDG F +
Sbjct: 184 TLKVYDYKGSGVAMAMYNTDESIEGFAHSSFKLAIDKKLNLFLSTKNTILKKYDGRFKDI 243
Query: 253 FQRMYDTKYREQFERLNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFG 312
FQ +Y+ +Y+ +FE+L + Y HRLIDD VAQMIK GGF+ A KNYDGDVQSDIVAQGFG
Sbjct: 244 FQEVYEAQYKSKFEQLGIHYEHRLIDDMVAQMIKSKGGFIMALKNYDGDVQSDIVAQGFG 303
Query: 313 SLGLMTSVLLCPDGKTIESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKL 372
SLGLMTS+L+ PDGKT ESEAAHGTVTRHYR++QKG+ETSTNS+ASIFAW+RGL RG+L
Sbjct: 304 SLGLMTSILVTPDGKTFESEAAHGTVTRHYRKYQKGEETSTNSIASIFAWSRGLLKRGEL 363
Query: 373 DGNAPLVEFASSLERATIKTI-EGGHMTKDLALCVHGAAALQRSHYETTEVFIDSVAEEL 431
D L +FA+ LE AT+ T+ + G MTKDLAL +RS Y TTE F+D+V + L
Sbjct: 364 DNTPALCKFANILESATLNTVQQDGIMTKDLAL---ACGNNERSAYVTTEEFLDAVEKRL 420
Query: 432 ARSVK 436
+ +K
Sbjct: 421 QKEIK 425
>ref|XP_001608101.1| PREDICTED: similar to isocitrate dehydrogenase [Nasonia
vitripennis]
Length = 409
Score = 559 bits (1440), Expect = e-157, Method: Composition-based stats.
Identities = 264/402 (65%), Positives = 319/402 (79%), Gaps = 2/402 (0%)
Query: 35 SGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQAAEAIQR 94
+G VVD+ GDEMTRIIW LIK+KLILP++D+ + YDL + +RDA++DKVT AEAI++
Sbjct: 7 AGPVVDILGDEMTRIIWDLIKQKLILPYLDIELHTYDLGMENRDATDDKVTVDCAEAIKK 66
Query: 95 HNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRVVPQWSE 154
+NVGIKCATITPDE RV+EF LKKMWKSPNGTIRNILGGTVFRE II KN+PR+V W +
Sbjct: 67 YNVGIKCATITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVGGWEK 126
Query: 155 PIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNFKGEGVGLAMYNTRE 213
PII+GRHA+ DQYKA + + P PG+LEL T +G Q V FKG G+ A +NT E
Sbjct: 127 PIIIGRHAHADQYKAVDFVVPGPGKLELTWTSPSGEKIQ-HTVNEFKGAGIAQAQFNTDE 185
Query: 214 SVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFERLNLTYV 273
S++AFA S F+YA+ R+YPL LSTKNTILK+YDG F FQ +Y+ +Y+ QFE LN+ Y
Sbjct: 186 SIQAFAHSSFKYALARKYPLYLSTKNTILKQYDGRFKNIFQEIYEKEYKSQFEALNIWYE 245
Query: 274 HRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDGKTIESEA 333
HRLIDD VA +K NGG+VWACKNYDGDVQSD VAQGFGSLGLMTSVLLCPDGKT+E+EA
Sbjct: 246 HRLIDDMVAYCMKSNGGYVWACKNYDGDVQSDSVAQGFGSLGLMTSVLLCPDGKTVEAEA 305
Query: 334 AHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLERATIKTI 393
AHGTVTRHYR HQ+GKETSTN +ASIFAWT+GL HR KLD NAPL +FA +LE+ + TI
Sbjct: 306 AHGTVTRHYRMHQQGKETSTNPIASIFAWTQGLLHRAKLDNNAPLKKFAETLEKVCVSTI 365
Query: 394 EGGHMTKDLALCVHGAAALQRSHYETTEVFIDSVAEELARSV 435
E G MTKDLALC+ A ++RS Y T F+D +AE L +S+
Sbjct: 366 ESGFMTKDLALCIKKADDVKRSDYLNTFEFLDKLAENLKKSL 407
>ref|XP_001457045.1| hypothetical protein GSPATT00022820001 [Paramecium tetraurelia
strain d4-2]
emb|CAK89648.1| unnamed protein product [Paramecium tetraurelia]
Length = 411
Score = 558 bits (1439), Expect = e-157, Method: Composition-based stats.
Identities = 264/404 (65%), Positives = 316/404 (78%), Gaps = 3/404 (0%)
Query: 30 GRIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQAA 89
+IKV VV+MDGDEMTR+IWA IKE LI P +D+PI+YYDL + +RD ++DKVT + A
Sbjct: 3 AKIKVDNPVVEMDGDEMTRVIWAWIKEYLITPFLDIPIKYYDLGMENRDQTDDKVTVECA 62
Query: 90 EAIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRVV 149
+AIQ VGIKCATITPDEARVKEFNLK MWKSPNGTIRNIL GTVFREPI++KN+PR+V
Sbjct: 63 KAIQECKVGIKCATITPDEARVKEFNLKYMWKSPNGTIRNILNGTVFREPILIKNIPRLV 122
Query: 150 PQWSEPIIVGRHAYGDQYKATESLF-PPGRLELVHTPANGGSPQVLEVFNFKGE-GVGLA 207
P W++PII+GRHA+GDQYKAT+ F G+ E++ TP +G PQ +EVF+F+G GV +A
Sbjct: 123 PGWTKPIIIGRHAFGDQYKATDLRFQKEGKFEVLFTPKDGSEPQRVEVFDFQGTGGVAMA 182
Query: 208 MYNTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFER 267
MYNT ES+ AFA +CF++AI YPL LSTKNTILK YDG F + FQ +YDTKY+ F+
Sbjct: 183 MYNTDESITAFAHACFQHAIELGYPLYLSTKNTILKVYDGRFKDIFQHLYDTKYKADFDA 242
Query: 268 LNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDGK 327
+ Y HRLIDD VA MIK GGFVWACKNYDGDVQSD +AQGFGSLGLMTSVL+ PDG
Sbjct: 243 KKIWYEHRLIDDMVAYMIKSEGGFVWACKNYDGDVQSDTLAQGFGSLGLMTSVLVSPDG- 301
Query: 328 TIESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLER 387
+E+EAAHGTVTRHYR HQ+GKETSTNS+ASI+AWTRGL HR KLD N L F ++LE
Sbjct: 302 CVEAEAAHGTVTRHYRLHQQGKETSTNSIASIYAWTRGLLHRAKLDNNKELERFCNTLEA 361
Query: 388 ATIKTIEGGHMTKDLALCVHGAAALQRSHYETTEVFIDSVAEEL 431
+ I+ +E G MTKDLA+CVH + R Y T FI VAE L
Sbjct: 362 SIIEAVEKGFMTKDLAICVHNTMNVPRDQYLNTLEFIQKVAEVL 405
>gb|ACO14957.1| Isocitrate dehydrogenase cytoplasmic [Caligus clemensi]
Length = 409
Score = 558 bits (1439), Expect = e-157, Method: Composition-based stats.
Identities = 261/402 (64%), Positives = 312/402 (77%), Gaps = 1/402 (0%)
Query: 35 SGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQAAEAIQR 94
+G VVD+ GDEMTRIIW LIKEKLI PH++V + YDL I RD ++DKVT AEAI++
Sbjct: 6 AGPVVDILGDEMTRIIWDLIKEKLIFPHLEVELHTYDLGIEYRDKTDDKVTVDCAEAIKK 65
Query: 95 HNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRVVPQWSE 154
+NVGIKCATITPDE RV+EFNLKKMW+SPNGTIRNILGGTVFRE II KN+PR+V W++
Sbjct: 66 YNVGIKCATITPDENRVEEFNLKKMWRSPNGTIRNILGGTVFREAIICKNIPRLVTTWNK 125
Query: 155 PIIVGRHAYGDQYKATESLFPP-GRLELVHTPANGGSPQVLEVFNFKGEGVGLAMYNTRE 213
PI+VGRHA+ DQYKA + P G LELV PANGG ++ +FKG GV L MYNT E
Sbjct: 126 PIVVGRHAHADQYKAQDFKVPSEGTLELVFKPANGGEAMNYKIHDFKGPGVALGMYNTDE 185
Query: 214 SVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFERLNLTYV 273
S++ FA CF++++ R YPL LSTKNTILKKYDG F + FQ +YD +Y+ FE + Y
Sbjct: 186 SIKDFAHCCFKFSLDRGYPLFLSTKNTILKKYDGAFKDIFQSIYDKEYKSDFEAKGIYYE 245
Query: 274 HRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDGKTIESEA 333
HRLIDD VAQ +K GGFVWACKNYDGDVQSD VAQG+GSLG+MTSVL+CPDGKT+E+EA
Sbjct: 246 HRLIDDMVAQAMKSEGGFVWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEA 305
Query: 334 AHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLERATIKTI 393
AHGTVTRHYR HQ+GKETSTN +ASIFAWTRGLAHR KLD N L F +LE I+TI
Sbjct: 306 AHGTVTRHYRFHQRGKETSTNPIASIFAWTRGLAHRAKLDNNKGLANFCQALEDTCIETI 365
Query: 394 EGGHMTKDLALCVHGAAALQRSHYETTEVFIDSVAEELARSV 435
E G MTKDLA+CV G A ++R Y T F+D ++E L + +
Sbjct: 366 ESGFMTKDLAICVKGMANVKREDYLNTFEFLDKLSENLKKKL 407
>ref|NP_509875.1| C34F6.8 [Caenorhabditis elegans]
emb|CAB03943.1| Hypothetical protein C34F6.8 [Caenorhabditis elegans]
Length = 435
Score = 558 bits (1437), Expect = e-157, Method: Composition-based stats.
Identities = 260/408 (63%), Positives = 318/408 (77%), Gaps = 2/408 (0%)
Query: 31 RIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQAAE 90
+IKV VVD+DGDEMTRIIW IK KLILP++D+ I+YYDL + RD +ND+VT AA
Sbjct: 26 KIKVDNPVVDLDGDEMTRIIWKEIKNKLILPYLDLDIKYYDLGLEYRDETNDQVTIDAAH 85
Query: 91 AIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRVVP 150
AI H+VGIKCATITPDEAR+KEFNLKKMW SPNGTIRNILGGTVFREPI+ KN+PR+VP
Sbjct: 86 AILEHSVGIKCATITPDEARIKEFNLKKMWLSPNGTIRNILGGTVFREPILCKNIPRLVP 145
Query: 151 QWSEPIIVGRHAYGDQYKATESLFPPGRLELVHTPANGGSPQVLEVFNFKGEG-VGLAMY 209
W++PI +GRHA+GDQYK T+ + P G + GS V V++FK G VGLAMY
Sbjct: 146 GWTQPITIGRHAFGDQYKCTDLVIPSGSTLQLLVNKPDGSKDVHNVYDFKKSGGVGLAMY 205
Query: 210 NTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFERLN 269
NT ES++ FA SCF+YA+M+++PL LSTKNTILKKYDG F + FQ +Y+ KY F+
Sbjct: 206 NTDESIKGFAHSCFQYALMKQWPLYLSTKNTILKKYDGRFKDIFQDIYEKKYEADFKNNK 265
Query: 270 LTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDGKTI 329
+ Y HRLIDDQVAQ +K +GGFVWACKNYDGDVQSDIVAQG+GSLGLM+SVL+CPDGKTI
Sbjct: 266 IWYEHRLIDDQVAQALKSSGGFVWACKNYDGDVQSDIVAQGYGSLGLMSSVLMCPDGKTI 325
Query: 330 ESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLERAT 389
E+EAAHGTVTRHYREHQKG TSTN +ASIFAWTRGL HRG LD N L F+ +LE+A
Sbjct: 326 EAEAAHGTVTRHYREHQKGNSTSTNPIASIFAWTRGLHHRGVLDNNEALKTFSLTLEKAC 385
Query: 390 IKTIEGGHMTKDLALCVHGA-AALQRSHYETTEVFIDSVAEELARSVK 436
I T+E G MTKDL++C+HG ++ Y TE F+ ++ ++A ++
Sbjct: 386 IDTVEEGKMTKDLSICIHGTKKGTEKGAYLITEDFLSAIDTKMAELMR 433
>ref|XP_001688948.1| AGAP006660-PA [Anopheles gambiae str. PEST]
ref|XP_001688949.1| AGAP006660-PB [Anopheles gambiae str. PEST]
ref|XP_316694.4| AGAP006660-PC [Anopheles gambiae str. PEST]
gb|EDO63954.1| AGAP006660-PA [Anopheles gambiae str. PEST]
gb|EDO63955.1| AGAP006660-PB [Anopheles gambiae str. PEST]
gb|EAA11493.4| AGAP006660-PC [Anopheles gambiae str. PEST]
Length = 413
Score = 558 bits (1437), Expect = e-157, Method: Composition-based stats.
Identities = 261/398 (65%), Positives = 313/398 (78%), Gaps = 1/398 (0%)
Query: 35 SGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQAAEAIQR 94
+G VVD+ GDEMTRIIW IKEKLILP +D+ + YDL I RDA+ND+VT AEA++R
Sbjct: 7 AGPVVDILGDEMTRIIWDSIKEKLILPFLDIELHTYDLGIEHRDATNDQVTIDCAEAVKR 66
Query: 95 HNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRVVPQWSE 154
+NVGIKCATITPDEARV+EF LK+MW+SPNGTIRNILGGTVFRE II KNVPR+VP W +
Sbjct: 67 YNVGIKCATITPDEARVEEFKLKQMWRSPNGTIRNILGGTVFREAIICKNVPRLVPGWEK 126
Query: 155 PIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNFKGEGVGLAMYNTRE 213
PII+GRHA+GDQYKAT+ + P PG+LE+ TPA+G P V +K GV + MYN +
Sbjct: 127 PIIIGRHAHGDQYKATDFVVPVPGKLEMKFTPADGSEPTTYVVNEYKSAGVAMGMYNLDD 186
Query: 214 SVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFERLNLTYV 273
S+ FA S F+ A+ R++PL LSTKNTILKKYDG F + FQ +YD Y++QFE L + Y
Sbjct: 187 SICDFAHSSFKVALDRKFPLYLSTKNTILKKYDGRFKDIFQEIYDKDYKKQFEALGIWYE 246
Query: 274 HRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDGKTIESEA 333
HRLIDD VA +K GGFVWACKNYDGDVQSD VAQGFGSLGLMTSVL+CPDG+T+ESEA
Sbjct: 247 HRLIDDMVAYCMKAEGGFVWACKNYDGDVQSDTVAQGFGSLGLMTSVLVCPDGRTVESEA 306
Query: 334 AHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLERATIKTI 393
AHGTVTRHYR+HQ+GKETSTN +ASIFAWTRGL HR KLD NA L FA +LE+ I TI
Sbjct: 307 AHGTVTRHYRQHQQGKETSTNPIASIFAWTRGLLHRAKLDDNAELKRFAETLEKVCIDTI 366
Query: 394 EGGHMTKDLALCVHGAAALQRSHYETTEVFIDSVAEEL 431
E G MTKDLA+C+ G A ++R+ Y T F++ + E L
Sbjct: 367 ESGFMTKDLAICIKGMANVKRTDYMETFEFMNKLGENL 404
>ref|XP_001778590.1| predicted protein [Physcomitrella patens subsp. patens]
gb|EDQ56620.1| predicted protein [Physcomitrella patens subsp. patens]
Length = 417
Score = 557 bits (1436), Expect = e-157, Method: Composition-based stats.
Identities = 262/407 (64%), Positives = 326/407 (80%), Gaps = 4/407 (0%)
Query: 28 SLGRIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQ 87
+L +IKV +V+MDGDEMTRIIW +IKEKLILP+VDV ++YYDL I +RDA+ND+VT +
Sbjct: 2 ALEKIKVENPIVEMDGDEMTRIIWQMIKEKLILPYVDVELKYYDLGILNRDATNDRVTHE 61
Query: 88 AAEAIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPR 147
+AEA ++NV +KCATITPDE RVKEF LK+MW+SPNGTIRN+L GTVFREPI+ KN+PR
Sbjct: 62 SAEATLKYNVAVKCATITPDEGRVKEFGLKQMWRSPNGTIRNVLDGTVFREPILCKNIPR 121
Query: 148 VVPQWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNFKGE-GVG 205
+VP W++PI +GRHAYGDQYKAT+++F PG+L++V P NGG P L+V+++ G GV
Sbjct: 122 LVPGWTKPICIGRHAYGDQYKATDAVFKGPGKLKMVFEPDNGGEPIDLDVYHYNGAGGVA 181
Query: 206 LAMYNTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMY-DTKYREQ 264
L MYNT ES+ FA++ F A+ +++PL LSTKNTILKKYDG F + FQ ++ + + +
Sbjct: 182 LCMYNTDESIRGFAKASFTMAMQKKWPLYLSTKNTILKKYDGRFKDIFQEVFVNEGWEAK 241
Query: 265 FERLNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCP 324
F+ + Y HRLIDD VA +K G +VWACKNYDGDVQSD++AQGFGSLGLMTSVL+CP
Sbjct: 242 FKDAGIWYEHRLIDDMVAYALKSEGEYVWACKNYDGDVQSDMLAQGFGSLGLMTSVLICP 301
Query: 325 DGKTIESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASS 384
DGKTIE+EAAHGTVTRH+R HQKG ETSTNS+ASIFAWTRGL HR LDGNA L EFA S
Sbjct: 302 DGKTIEAEAAHGTVTRHFRVHQKGGETSTNSIASIFAWTRGLGHRALLDGNAKLQEFAQS 361
Query: 385 LERATIKTIEGGHMTKDLALCVHGAAALQRSHYETTEVFIDSVAEEL 431
LE A I T+E G MTKDLAL HG + R++Y TE FID+VA+EL
Sbjct: 362 LEAACIATVESGKMTKDLALLSHG-PNVSRNNYLNTEEFIDAVADEL 407
>ref|NP_001043749.1| Os01g0654500 [Oryza sativa (japonica cultivar-group)]
gb|AAD37809.1|AF155333_1 NADP-specific isocitrate dehydrogenase [Oryza sativa]
dbj|BAB90451.1| putative NADP-specific isocitrate dehydrogenase [Oryza sativa
Japonica Group]
dbj|BAD72316.1| putative NADP-specific isocitrate dehydrogenase [Oryza sativa
Japonica Group]
dbj|BAF05663.1| Os01g0654500 [Oryza sativa (japonica cultivar-group)]
gb|EAY75221.1| hypothetical protein OsI_003068 [Oryza sativa (indica
cultivar-group)]
gb|EAZ12940.1| hypothetical protein OsJ_002765 [Oryza sativa (japonica
cultivar-group)]
Length = 412
Score = 557 bits (1436), Expect = e-157, Method: Composition-based stats.
Identities = 266/404 (65%), Positives = 323/404 (79%), Gaps = 6/404 (1%)
Query: 31 RIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQAAE 90
+IKV+ +V+MDGDEMTRI W IK+KLI P +D+ I+YYDL + RDA++DKVT +AAE
Sbjct: 5 KIKVANPIVEMDGDEMTRIFWQSIKDKLIFPFLDLDIKYYDLGVLHRDATDDKVTVEAAE 64
Query: 91 AIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRVVP 150
A ++NV IKCATITPDEARVKEFNLK+MWKSPNGTIRNI+ GTVFREPII KNVPR+VP
Sbjct: 65 ATLKYNVAIKCATITPDEARVKEFNLKQMWKSPNGTIRNIINGTVFREPIICKNVPRLVP 124
Query: 151 QWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQV-LEVFNFKGEG-VGLA 207
W++PI +GRHA+GDQY+AT+++ PG+L+LV G Q+ LEVFNF G G V L+
Sbjct: 125 GWTKPICIGRHAFGDQYRATDAVLKGPGKLKLVF---EGKDEQIDLEVFNFTGAGGVALS 181
Query: 208 MYNTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFER 267
MYNT ES+ AFAE+ A +++PL LSTKNTILKKYDG F + FQ +Y+ ++ +FE
Sbjct: 182 MYNTDESIRAFAEASMTTAYEKKWPLYLSTKNTILKKYDGRFKDIFQEVYEAGWKSKFEA 241
Query: 268 LNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDGK 327
+ Y HRLIDD VA +K GG+VWACKNYDGDVQSD +AQGFGSLGLMTSVL+CPDGK
Sbjct: 242 AGIWYEHRLIDDMVAYALKSEGGYVWACKNYDGDVQSDFLAQGFGSLGLMTSVLVCPDGK 301
Query: 328 TIESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLER 387
TIE+EAAHGTVTRH+R HQKG ETSTNS+ASIFAWTRGLAHR KLD NA L++FA LE
Sbjct: 302 TIEAEAAHGTVTRHFRVHQKGGETSTNSIASIFAWTRGLAHRAKLDDNARLLDFALKLEA 361
Query: 388 ATIKTIEGGHMTKDLALCVHGAAALQRSHYETTEVFIDSVAEEL 431
A + T+E G MTKDLAL +HG++ + RSHY TE FID+VA EL
Sbjct: 362 ACVGTVESGKMTKDLALLIHGSSNVTRSHYLNTEEFIDAVAAEL 405
>gb|AAC64182.1| NADP-dependent isocitrate dehydrogenase [Glycine max]
Length = 416
Score = 557 bits (1435), Expect = e-157, Method: Composition-based stats.
Identities = 260/403 (64%), Positives = 325/403 (80%), Gaps = 3/403 (0%)
Query: 31 RIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQAAE 90
+I+V +V+MDGDEMTR+IW LIK+KLI P++++ I+Y+DL + RDA+ND+VT ++AE
Sbjct: 5 KIRVGNPIVEMDGDEMTRVIWKLIKDKLIFPYLELDIKYFDLGLPHRDATNDRVTIESAE 64
Query: 91 AIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRVVP 150
A ++NV IKCATITPDEARVKEFNLK+MW+SPNGTIRNIL GTVFREPII KN+PR+V
Sbjct: 65 ATLKYNVAIKCATITPDEARVKEFNLKQMWRSPNGTIRNILNGTVFREPIICKNIPRLVS 124
Query: 151 QWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNFKGEG-VGLAM 208
W++PI +GRHA+GDQY+AT+++ PG+L+LV P+ + LEV+NF G G + L+M
Sbjct: 125 GWTKPICIGRHAFGDQYRATDTVIKGPGKLKLVFAPSGNEGIKELEVYNFTGAGGIALSM 184
Query: 209 YNTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFERL 268
YNT ES+ AFAE+ +A +++PL LSTKNTILKKYDG F + FQ ++DT++ +F+
Sbjct: 185 YNTDESIRAFAEASMNFAYQKKWPLYLSTKNTILKKYDGRFKDIFQEVFDTQWNHKFKAA 244
Query: 269 NLTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDGKT 328
+ Y HRLIDD VA +K +GG+VWACKNYDGDVQSD +AQGFGSLGLMTSVL+CPDGKT
Sbjct: 245 GIWYEHRLIDDMVAYALKSDGGYVWACKNYDGDVQSDFLAQGFGSLGLMTSVLVCPDGKT 304
Query: 329 IESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLERA 388
IE+EAAHGTVTRHYR HQKG ETSTNS+ASIFAW+RGLAHR KLDGNA L++F LE A
Sbjct: 305 IEAEAAHGTVTRHYRVHQKGGETSTNSIASIFAWSRGLAHRPKLDGNARLLDFTEKLEAA 364
Query: 389 TIKTIEGGHMTKDLALCVHGAAALQRSHYETTEVFIDSVAEEL 431
I T+E G MTKDLAL VHG + RS Y TE FID+VAEEL
Sbjct: 365 CIGTVELGKMTKDLALLVHG-PKVSRSQYLNTEEFIDAVAEEL 406
Searching..................................................done
Results from round 2
Score E
Sequences producing significant alignments: (bits) Value
Sequences used in model and found again:
ref|XP_847200.1| isocitrate dehydrogenase [NADP], mitochond... 763 0.0
gb|ABE98244.1| mitochondrial isocitrate dehydrogenase 2-lik... 712 0.0
gb|ABF20272.1| mitochondrial isocitrate dehydrogenase [Leis... 710 0.0
ref|NP_786984.1| isocitrate dehydrogenase 2 (NADP+), mitoch... 710 0.0
ref|NP_955858.1| isocitrate dehydrogenase 2 (NADP+), mitoch... 708 0.0
sp|Q04467|IDHP_BOVIN Isocitrate dehydrogenase [NADP], mitoc... 708 0.0
gb|ACO14046.1| Isocitrate dehydrogenase, mitochondrial prec... 707 0.0
ref|NP_970434.1| isocitrate dehydrogenase [Bdellovibrio bac... 706 0.0
ref|NP_001026770.1| hypothetical protein LOC431056 [Gallus ... 705 0.0
ref|XP_001095686.1| PREDICTED: isocitrate dehydrogenase 2 (... 703 0.0
ref|XP_001369305.1| PREDICTED: hypothetical protein [Monode... 703 0.0
ref|XP_510589.2| PREDICTED: isocitrate dehydrogenase 2 (NAD... 703 0.0
ref|XP_536192.2| PREDICTED: similar to isocitrate dehydroge... 703 0.0
sp|P54071|IDHP_MOUSE Isocitrate dehydrogenase [NADP], mitoc... 703 0.0
ref|NP_002159.2| isocitrate dehydrogenase 2 (NADP+), mitoch... 702 0.0
ref|NP_766599.1| isocitrate dehydrogenase 2 (NADP+), mitoch... 701 0.0
emb|CAA49208.1| isocitrate dehydrogenase (NADP+) [Homo sapi... 701 0.0
dbj|BAC77065.1| NADP-specific isocitrate dehydrogenase [Lup... 701 0.0
ref|NP_001014183.1| isocitrate dehydrogenase 2 (NADP+), mit... 701 0.0
sp|P33198|IDHP_PIG Isocitrate dehydrogenase [NADP], mitocho... 700 0.0
pdb|1LWD|A Chain A, Crystal Structure Of Nadp-Dependent Iso... 700 0.0
dbj|BAD96636.1| isocitrate dehydrogenase 2 (NADP+), mitocho... 700 0.0
gb|ABF20244.1| mitochondrial isocitrate dehydrogenase [Leis... 700 0.0
ref|XP_001463680.1| isocitrate dehydrogenase [NADP], mitoch... 700 0.0
ref|NP_001080321.1| hypothetical protein LOC380013 [Xenopus... 699 0.0
ref|XP_421965.2| PREDICTED: similar to cytosolic NADP-depen... 699 0.0
gb|EAX02083.1| isocitrate dehydrogenase 2 (NADP+), mitochon... 699 0.0
gb|ABU41004.1| isocitrate dehydrogenase 1 [Anser anser] 698 0.0
ref|XP_001778805.1| predicted protein [Physcomitrella paten... 698 0.0
ref|XP_001168316.1| PREDICTED: isocitrate dehydrogenase 2 (... 698 0.0
ref|XP_001681361.1| isocitrate dehydrogenase [NADP], mitoch... 698 0.0
ref|XP_001107627.1| PREDICTED: isocitrate dehydrogenase 1 (... 697 0.0
ref|NP_001088022.1| hypothetical protein LOC494713 [Xenopus... 696 0.0
ref|NP_851355.2| isocitrate dehydrogenase 1 (NADP+), solubl... 696 0.0
ref|NP_001009276.1| cytosolic NADP-isocitrate dehydrogenase... 696 0.0
sp|Q9Z2K9|IDHC_MICME Isocitrate dehydrogenase [NADP] cytopl... 696 0.0
ref|XP_850187.1| PREDICTED: similar to Isocitrate dehydroge... 696 0.0
ref|ZP_01885694.1| isocitrate dehydrogenase [Pedobacter sp.... 696 0.0
emb|CAA53300.1| isocitrate dehydrogenase (NADP+) [Solanum t... 696 0.0
ref|NP_113698.1| isocitrate dehydrogenase 1 (NADP+), solubl... 696 0.0
sp|Q9Z2K8|IDHC_MICOH Isocitrate dehydrogenase [NADP] cytopl... 696 0.0
gb|ABF20271.1| mitochondrial isocitrate dehydrogenase [Leis... 695 0.0
ref|XP_001562802.1| isocitrate dehydrogenase [NADP], mitoch... 695 0.0
sp|Q9XSG3|IDHC_BOVIN Isocitrate dehydrogenase [NADP] cytopl... 694 0.0
dbj|BAC39792.1| unnamed protein product [Mus musculus] 694 0.0
ref|XP_001168291.1| PREDICTED: isocitrate dehydrogenase 2 (... 694 0.0
ref|XP_001698704.1| isocitrate dehydrogenase, NADP-dependen... 693 0.0
ref|NP_001004799.1| MGC69505 protein [Xenopus tropicalis] >... 693 0.0
sp|O88844|IDHC_MOUSE Isocitrate dehydrogenase [NADP] cytopl... 693 0.0
emb|CAG38738.1| IDH1 [Homo sapiens] 693 0.0
ref|XP_813368.1| isocitrate dehydrogenase [NADP], mitochond... 693 0.0
ref|XP_860821.1| PREDICTED: similar to Isocitrate dehydroge... 693 0.0
ref|NP_539708.1| isocitrate dehydrogenase [Brucella meliten... 693 0.0
ref|XP_001505172.1| PREDICTED: similar to Isocitrate dehydr... 693 0.0
ref|NP_005887.2| isocitrate dehydrogenase 1 (NADP+), solubl... 693 0.0
pdb|2CMJ|A Chain A, Crystal Structure Of Mouse Cytosolic Is... 693 0.0
ref|XP_970446.1| PREDICTED: similar to isocitrate dehydroge... 693 0.0
emb|CAG13105.1| unnamed protein product [Tetraodon nigrovir... 692 0.0
ref|XP_001141655.1| PREDICTED: isocitrate dehydrogenase 1 (... 692 0.0
emb|CAM77136.1| Isocitrate/isopropylmalate dehydrogenase [M... 692 0.0
ref|XP_001511049.1| PREDICTED: similar to cytosolic NADP-de... 692 0.0
ref|NP_034627.3| isocitrate dehydrogenase 1 (NADP+), solubl... 692 0.0
sp|Q5R9C5|IDHC_PONPY Isocitrate dehydrogenase [NADP] cytopl... 692 0.0
dbj|BAE39644.1| unnamed protein product [Mus musculus] 692 0.0
ref|NP_698203.1| isocitrate dehydrogenase [Brucella suis 13... 692 0.0
sp|Q40345|IDHP_MEDSA Isocitrate dehydrogenase [NADP], chlor... 691 0.0
gb|AAH88986.1| Isocitrate dehydrogenase 1 (NADP+), soluble ... 691 0.0
gb|AAH93020.1| Isocitrate dehydrogenase 1 (NADP+), soluble ... 691 0.0
emb|CAH89719.1| hypothetical protein [Pongo abelii] 691 0.0
emb|CAD97653.1| hypothetical protein [Homo sapiens] >gi|117... 689 0.0
ref|NP_001043749.1| Os01g0654500 [Oryza sativa (japonica cu... 689 0.0
emb|CAG02362.1| unnamed protein product [Tetraodon nigrovir... 689 0.0
emb|CAH91635.1| hypothetical protein [Pongo abelii] 689 0.0
ref|XP_001633903.1| predicted protein [Nematostella vectens... 689 0.0
ref|NP_001056381.1| Os05g0573200 [Oryza sativa (japonica cu... 689 0.0
gb|AAB39248.1| NADP-isocitrate dehydrogenase [Eucalyptus gl... 689 0.0
gb|AAC64182.1| NADP-dependent isocitrate dehydrogenase [Gly... 689 0.0
emb|CAB66637.1| hypothetical protein [Homo sapiens] >gi|117... 688 0.0
ref|XP_001168261.1| PREDICTED: isocitrate dehydrogenase 2 (... 688 0.0
ref|XP_001688948.1| AGAP006660-PA [Anopheles gambiae str. P... 688 0.0
ref|YP_677841.1| isocitrate dehydrogenase [Cytophaga hutchi... 688 0.0
emb|CAA65503.1| isocitrate dehydrogenase (NADP+) [Nicotiana... 688 0.0
ref|XP_001841910.1| isocitrate dehydrogenase cytoplasmic [C... 688 0.0
dbj|BAE48792.1| NADP-isocitrate dehydrogenase [Codonopsis l... 688 0.0
gb|AAA33978.1| NADPH-specific isocitrate dehydrogenase 687 0.0
emb|CAA65504.1| isocitrate dehydrogenase (NADP+) [Nicotiana... 687 0.0
gb|AAV33246.1| isocitrate dehydrogenase [Toxoplasma gondii] 686 0.0
sp|P50218|IDHC_TOBAC Isocitrate dehydrogenase [NADP] (Oxalo... 686 0.0
ref|NP_196963.2| isocitrate dehydrogenase, putative / NADP+... 686 0.0
ref|XP_312860.4| AGAP003168-PA [Anopheles gambiae str. PEST... 686 0.0
ref|NP_385898.1| isocitrate dehydrogenase [Sinorhizobium me... 686 0.0
ref|YP_002826161.1| NADP isocitrate dehydrogenase [Rhizobiu... 686 0.0
pir||S33612 isocitrate dehydrogenase (NADP) (EC 1.1.1.42) -... 686 0.0
ref|YP_419971.1| isocitrate dehydrogenase [Magnetospirillum... 686 0.0
sp|P50217|IDHC_SOLTU Isocitrate dehydrogenase [NADP] (Oxalo... 686 0.0
ref|XP_860853.1| PREDICTED: similar to Isocitrate dehydroge... 686 0.0
ref|ZP_00056387.1| COG0538: Isocitrate dehydrogenases [Magn... 686 0.0
gb|AAF73472.1|AF268076_1 NADP-dependent isocitrate dehydrog... 686 0.0
gb|AAD51361.1|AF176669_1 NADP-isocitrate dehydrogenase [Cit... 685 0.0
ref|YP_001370537.1| isocitrate dehydrogenase, NADP-dependen... 685 0.0
gb|AAD02918.1| NADP-dependent isocitrate dehydrogenase [Hom... 685 0.0
ref|XP_001365492.1| PREDICTED: similar to cytosolic NADP-de... 685 0.0
gb|AAL11503.1|AF367443_1 NADP-dependent isocitrate dehydrog... 685 0.0
ref|YP_001327198.1| isocitrate dehydrogenase [Sinorhizobium... 684 0.0
ref|XP_001650675.1| nadp-specific isocitrate dehydrogenase ... 684 0.0
ref|XP_968850.1| PREDICTED: similar to CG7176-PC, isoform C... 684 0.0
emb|CAG38553.1| IDH1 [Homo sapiens] 684 0.0
gb|ABK24873.1| unknown [Picea sitchensis] 684 0.0
ref|ZP_02188085.1| Isocitrate dehydrogenase [alpha proteoba... 684 0.0
ref|NP_958907.1| isocitrate dehydrogenase 1 (NADP+), solubl... 684 0.0
dbj|BAC77063.1| NADP-specific isocitrate dehydrogenase [Lup... 684 0.0
dbj|BAA34113.1| NADP specific isocitrate dehydrogenase [Dau... 684 0.0
ref|XP_001778590.1| predicted protein [Physcomitrella paten... 684 0.0
emb|CAQ15240.1| isocitrate dehydrogenase 1 (NADP+), soluble... 683 0.0
dbj|BAA34112.1| NADP specific isocitrate dehydrogenase [Dau... 683 0.0
sp|Q06197|IDHC_SOYBN Isocitrate dehydrogenase [NADP] (Oxalo... 683 0.0
ref|YP_673828.1| isocitrate dehydrogenase [Mesorhizobium sp... 683 0.0
ref|NP_175836.1| ICDH; isocitrate dehydrogenase (NADP+) [Ar... 683 0.0
gb|ABA18651.1| cytosolic NADP+-isocitrate dehydrogenase [Po... 682 0.0
emb|CAG02627.1| unnamed protein product [Tetraodon nigrovir... 682 0.0
gb|ACO14957.1| Isocitrate dehydrogenase cytoplasmic [Caligu... 682 0.0
ref|XP_001176537.1| PREDICTED: similar to Isocitrate dehydr... 682 0.0
gb|AAT06312.1| isocitrate dehydrogenase [Rhizobium legumino... 682 0.0
ref|XP_451683.1| unnamed protein product [Kluyveromyces lac... 681 0.0
ref|XP_001240510.1| isocitrate dehydrogenase NADP, mitochon... 681 0.0
ref|YP_425448.1| isocitrate dehydrogenase [Rhodospirillum r... 681 0.0
prf||2211361A isocitrate dehydrogenase 681 0.0
gb|AAC52473.1| isocitrate dehydrogenase 681 0.0
dbj|BAC77064.1| NADP-specific isocitrate dehydrogenase [Lup... 681 0.0
ref|YP_768215.1| isocitrate dehydrogenase [Rhizobium legumi... 681 0.0
ref|ZP_02295934.1| isocitrate dehydrogenase, NADP-dependent... 681 0.0
emb|CAA73139.1| isocitrate dehydrogenase (NADP+) [Apium gra... 681 0.0
ref|ZP_02166681.1| isocitrate dehydrogenase [Hoeflea photot... 681 0.0
ref|NP_101923.1| isocitrate dehydrogenase [Mesorhizobium lo... 681 0.0
ref|YP_290624.1| isocitrate dehydrogenase [Thermobifida fus... 681 0.0
emb|CAD24779.1| isocitrate dehydrogenase [Cucumis sativus] 680 0.0
ref|XP_821599.1| isocitrate dehydrogenase, putative [Trypan... 680 0.0
emb|CAN72808.1| hypothetical protein [Vitis vinifera] >gi|1... 680 0.0
ref|ZP_02858718.1| isocitrate dehydrogenase, NADP-dependent... 680 0.0
ref|YP_001524781.1| NADP-dependent isocitrate dehydrogenase... 680 0.0
ref|YP_001296741.1| isocitrate dehydrogenase [Flavobacteriu... 680 0.0
ref|XP_623673.2| PREDICTED: similar to Isocitrate dehydroge... 679 0.0
ref|XP_001384028.1| Isocitrate dehydrogenase [NADP], mitoch... 679 0.0
ref|YP_001609735.1| NADP-dependent isocitrate dehydrogenase... 679 0.0
ref|XP_001608101.1| PREDICTED: similar to isocitrate dehydr... 679 0.0
ref|NP_421325.1| isocitrate dehydrogenase [Caulobacter cres... 679 0.0
gb|AAS49171.1| NADP-dependent isocitrate dehydrogenase [Pis... 679 0.0
gb|EEJ98364.1| isocitrate dehydrogenase (NADP) [Thermomonos... 679 0.0
gb|ABI52605.1| isocitrate dehydrogenase [Gryllus firmus] 679 0.0
ref|YP_001685152.1| isocitrate dehydrogenase, NADP-dependen... 679 0.0
gb|EDT29808.1| isocitrate dehydrogenase, NADP-dependent [Ol... 679 0.0
ref|ZP_02124492.1| Isocitrate dehydrogenase (NADP(+)) [Meth... 679 0.0
ref|ZP_03891012.1| isocitrate dehydrogenase (NADP) [Geoderm... 678 0.0
gb|AAR05796.1| NADP+-isocitrate dehydrogenase [Pinus pinaster] 678 0.0
emb|CAB87626.1| isocitrate dehydrogenase-like protein [Arab... 678 0.0
emb|CAA63220.1| isocitrate dehydrogenase (NAD+) [Solanum tu... 678 0.0
ref|NP_354851.2| isocitrate dehydrogenase [Agrobacterium tu... 677 0.0
ref|YP_001413846.1| isocitrate dehydrogenase, NADP-dependen... 676 0.0
ref|XP_955850.1| hypothetical protein NCU03857 [Neurospora ... 675 0.0
gb|EAY99113.1| hypothetical protein OsI_020346 [Oryza sativ... 674 0.0
ref|NP_001040134.1| isocitrate dehydrogenase [Bombyx mori] ... 674 0.0
ref|ZP_00952302.1| isocitrate dehydrogenase [Oceanicaulis a... 674 0.0
ref|YP_117132.1| isocitrate dehydrogenase [Nocardia farcini... 674 0.0
ref|ZP_03896321.1| isocitrate dehydrogenase (NADP) [Dyadoba... 674 0.0
ref|ZP_01228834.1| NADP dependent isocitrate dehydrogenase ... 673 0.0
ref|NP_001042583.1| Os01g0248400 [Oryza sativa (japonica cu... 673 0.0
ref|NP_001093090.1| NADPH-specific isocitrate dehydrogenase... 673 0.0
ref|XP_754749.1| isocitrate dehydrogenase Idp1 [Aspergillus... 672 0.0
gb|EDP52872.1| isocitrate dehydrogenase Idp1, putative [Asp... 672 0.0
ref|YP_706173.1| isocitrate dehydrogenase [Rhodococcus sp. ... 672 0.0
ref|YP_001419447.1| isocitrate dehydrogenase, NADP-dependen... 672 0.0
gb|ABO93633.1| isocitrate dehydrogenase 2 [Toxoplasma gondii] 672 0.0
ref|XP_001462393.1| hypothetical protein GSPATT00027349001 ... 672 0.0
ref|NP_176768.1| isocitrate dehydrogenase, putative / NADP+... 671 0.0
ref|YP_001769504.1| isocitrate dehydrogenase, NADP-dependen... 671 0.0
gb|AAK76730.1| mitochondrial NADP-dependent isocitrate dehy... 671 0.0
ref|XP_001845030.1| isocitrate dehydrogenase [Culex pipiens... 671 0.0
ref|XP_001454244.1| hypothetical protein GSPATT00020509001 ... 671 0.0
emb|CAD24782.1| isocitrate dehydrogenase [Arabidopsis thali... 671 0.0
ref|XP_710919.1| NADP-specific isocitrate dehydrogenase [Ca... 671 0.0
gb|AAM13090.1| similar to NADP-specific isocitrate dehydrog... 670 0.0
ref|NP_001053269.1| Os04g0508200 [Oryza sativa (japonica cu... 670 0.0
ref|ZP_03869030.1| isocitrate dehydrogenase (NADP) [Jonesia... 669 0.0
ref|XP_001670101.1| Hypothetical protein CBG21657 [Caenorha... 669 0.0
ref|YP_032403.1| isocitrate dehydrogenase [Bartonella quint... 669 0.0
ref|NP_010217.1| Mitochondrial NADP-specific isocitrate deh... 669 0.0
emb|CAO64975.1| unnamed protein product [Vitis vinifera] 669 0.0
ref|XP_001528456.1| isocitrate dehydrogenase, mitochondrial... 669 0.0
ref|YP_033790.1| isocitrate dehydrogenase [Bartonella hense... 669 0.0
ref|XP_001226620.1| conserved hypothetical protein [Chaetom... 668 0.0
gb|AAM65674.1| isocitrate dehydrogenase, putative [Arabidop... 668 0.0
emb|CAE04728.1| OSJNBa0043L24.16 [Oryza sativa (japonica cu... 668 0.0
ref|YP_001233708.1| isocitrate dehydrogenase [Acidiphilium ... 668 0.0
ref|YP_001538953.1| isocitrate dehydrogenase, NADP-dependen... 668 0.0
ref|YP_001160602.1| isocitrate dehydrogenase [Salinispora t... 668 0.0
ref|XP_459772.1| hypothetical protein DEHA0E11286g [Debaryo... 668 0.0
ref|YP_682929.1| isocitrate dehydrogenase [Roseobacter deni... 668 0.0
ref|XP_001903959.1| unnamed protein product [Podospora anse... 668 0.0
ref|NP_772387.1| isocitrate dehydrogenase [Bradyrhizobium j... 668 0.0
ref|XP_001676039.1| Hypothetical protein CBG17397 [Caenorha... 667 0.0
ref|XP_001426548.1| hypothetical protein GSPATT00029781001 ... 667 0.0
gb|AAT44354.1| isocitrate dehydrogenase [Crassostrea gigas] 667 0.0
ref|XP_001457045.1| hypothetical protein GSPATT00022820001 ... 667 0.0
ref|YP_001709366.1| isocitrate dehydrogenase [Clavibacter m... 667 0.0
ref|YP_872148.1| isocitrate dehydrogenase [Acidothermus cel... 667 0.0
ref|XP_001020930.2| dehydrogenase, isocitrate/isopropylmala... 667 0.0
ref|YP_617009.1| isocitrate dehydrogenase [Sphingopyxis ala... 667 0.0
ref|YP_002783489.1| isocitrate dehydrogenase [Rhodococcus o... 666 0.0
emb|CAH67563.1| OSIGBa0101P20.6 [Oryza sativa (indica culti... 666 0.0
ref|ZP_03819206.1| isocitrate dehydrogenase (NADP) [Actinos... 666 0.0
ref|YP_001223282.1| isocitrate dehydrogenase [Clavibacter m... 666 0.0
sp|P79089|IDHP_ASPNG Isocitrate dehydrogenase [NADP], mitoc... 666 0.0
ref|YP_001832264.1| isocitrate dehydrogenase, NADP-dependen... 666 0.0
ref|ZP_01440188.1| Isocitrate/isopropylmalate dehydrogenase... 666 0.0
ref|YP_002761841.1| NADP-dependent isocitrate dehydrogenase... 665 0.0
ref|YP_989041.1| isocitrate dehydrogenase [Bartonella bacil... 665 0.0
ref|YP_062774.1| isocitrate dehydrogenase [Leifsonia xyli s... 665 0.0
ref|NP_509875.1| C34F6.8 [Caenorhabditis elegans] >gi|38747... 665 0.0
ref|XP_504978.1| hypothetical protein [Yarrowia lipolytica]... 665 0.0
ref|YP_001849499.1| isocitrate dehydrogenase [NADP] Icd1 [M... 664 0.0
ref|ZP_01546031.1| isocitrate dehydrogenase [Stappia aggreg... 664 0.0
ref|ZP_01862723.1| isocitrate dehydrogenase [Erythrobacter ... 664 0.0
ref|ZP_02955422.1| isocitrate dehydrogenase, NADP-dependent... 664 0.0
gb|EAY58582.1| isocitrate dehydrogenase [NADP] icd1 [Mycoba... 663 0.0
ref|YP_756242.1| isocitrate dehydrogenase [Maricaulis maris... 663 0.0
ref|YP_001204807.1| isocitrate dehydrogenase [Bradyrhizobiu... 663 0.0
ref|ZP_01040029.1| isocitrate dehydrogenase [Erythrobacter ... 663 0.0
ref|XP_390523.1| hypothetical protein FG10347.1 [Gibberella... 663 0.0
ref|ZP_00954676.1| isocitrate dehydrogenase [Sulfitobacter ... 663 0.0
ref|NP_217856.1| isocitrate dehydrogenase [Mycobacterium tu... 663 0.0
ref|ZP_00964081.1| isocitrate dehydrogenase [Sulfitobacter ... 663 0.0
gb|ABL97438.1| isocitrate dehydrogenase [uncultured marine ... 663 0.0
ref|YP_001833636.1| isocitrate dehydrogenase, NADP-dependen... 663 0.0
ref|NP_949171.1| isocitrate dehydrogenase [Rhodopseudomonas... 662 0.0
ref|YP_496560.1| isocitrate dehydrogenase [Novosphingobium ... 662 0.0
ref|YP_979491.1| isocitrate dehydrogenase [Mycobacterium bo... 662 0.0
ref|XP_645284.1| isocitrate dehydrogenase (NADP+) [Dictyost... 662 0.0
ref|YP_002765452.1| NADP-dependent isocitrate dehydrogenase... 662 0.0
ref|XP_569234.1| isocitrate dehydrogenase (NADP+) [Cryptoco... 662 0.0
ref|XP_001400371.1| precursor of mitochondrial isocitrate d... 661 0.0
ref|YP_001241304.1| isocitrate dehydrogenase [Bradyrhizobiu... 661 0.0
ref|YP_001169228.1| isocitrate dehydrogenase [Rhodobacter s... 661 0.0
ref|YP_487337.1| isocitrate dehydrogenase [Rhodopseudomonas... 661 0.0
ref|ZP_00960755.1| Isocitrate dehydrogenase [Roseovarius nu... 661 0.0
ref|YP_001168561.1| isocitrate dehydrogenase [Rhodobacter s... 661 0.0
gb|AAK76731.1| peroxisomal NADP-dependent isocitrate dehydr... 661 0.0
ref|XP_001593497.1| hypothetical protein SS1G_04924 [Sclero... 660 0.0
ref|NP_501665.1| F59B8.2 [Caenorhabditis elegans] >gi|38778... 660 0.0
ref|ZP_02302766.1| isocitrate dehydrogenase, NADP-dependent... 660 0.0
ref|XP_569233.1| isocitrate dehydrogenase (NADP+) [Cryptoco... 660 0.0
ref|YP_001363715.1| isocitrate dehydrogenase, NADP-dependen... 660 0.0
ref|YP_001758392.1| isocitrate dehydrogenase, NADP-dependen... 660 0.0
ref|YP_458429.1| isocitrate dehydrogenase [Erythrobacter li... 660 0.0
ref|YP_568874.1| isocitrate dehydrogenase [Rhodopseudomonas... 660 0.0
ref|YP_001601185.1| Isocitrate dehydrogenase [Gluconacetoba... 660 0.0
ref|XP_001878769.1| predicted protein [Laccaria bicolor S23... 659 0.0
ref|YP_001043974.1| isocitrate dehydrogenase [Rhodobacter s... 659 0.0
gb|ABK25438.1| unknown [Picea sitchensis] 659 0.0
ref|ZP_01018081.1| isocitrate dehydrogenase [Parvularcula b... 659 0.0
ref|YP_001042101.1| isocitrate dehydrogenase [Rhodobacter s... 659 0.0
sp|O13285|IDH1_CANTR Isocitrate dehydrogenase [NADP], mitoc... 659 0.0
ref|XP_713421.1| cytosolic NADP-specific isocitrate dehydro... 658 0.0
ref|ZP_02981592.1| isocitrate dehydrogenase, NADP-dependent... 658 0.0
ref|XP_660603.1| IDHP_ASPNG ISOCITRATE DEHYDROGENASE [NADP]... 658 0.0
ref|YP_001108727.1| isocitrate dehydrogenase [Saccharopolys... 658 0.0
ref|XP_780121.1| PREDICTED: similar to cytosolic NADP-depen... 658 0.0
ref|ZP_01130474.1| isocitrate dehydrogenase [marine actinob... 658 0.0
ref|YP_001623415.1| isocitrate dehydrogenase (NADP) [Reniba... 658 0.0
ref|YP_353519.1| isocitrate dehydrogenase [Rhodobacter spha... 658 0.0
ref|XP_001837820.1| hypothetical protein CC1G_11465 [Coprin... 658 0.0
ref|ZP_01157336.1| isocitrate dehydrogenase [Oceanicola gra... 658 0.0
ref|ZP_01303522.1| isocitrate dehydrogenase, NADP-dependent... 657 0.0
ref|XP_828183.1| isocitrate dehydrogenase [Trypanosoma bruc... 657 0.0
ref|YP_351602.1| isocitrate dehydrogenase [Rhodobacter spha... 657 0.0
ref|XP_001263574.1| isocitrate dehydrogenase Idp1, putative... 656 0.0
ref|XP_001614236.1| isocitrate dehydrogenase [NADP], mitoch... 656 0.0
ref|YP_780531.1| isocitrate dehydrogenase [Rhodopseudomonas... 656 0.0
ref|ZP_02963068.1| isocitrate dehydrogenase [Bifidobacteriu... 656 0.0
ref|XP_001527573.1| isocitrate dehydrogenase peroxisomal [L... 656 0.0
gb|ABD36135.1| isocitrate dehydrogenase precursor [Bombyx m... 656 0.0
ref|XP_001484278.1| isocitrate dehydrogenase, mitochondrial... 656 0.0
ref|YP_531457.1| isocitrate dehydrogenase [Rhodopseudomonas... 656 0.0
ref|YP_909639.1| isocitrate dehydrogenase [Bifidobacterium ... 655 0.0
ref|ZP_00206729.1| COG0538: Isocitrate dehydrogenases [Bifi... 655 0.0
ref|ZP_01046178.1| isocitrate dehydrogenase NADP-dependent ... 655 0.0
ref|XP_725505.1| isocitrate dehydrogenase, NADP-dependent [... 655 0.0
ref|NP_962389.1| isocitrate dehydrogenase [Mycobacterium av... 654 0.0
ref|XP_001818331.1| hypothetical protein [Aspergillus oryza... 654 0.0
ref|YP_317907.1| isocitrate dehydrogenase [Nitrobacter wino... 654 0.0
ref|YP_576902.1| isocitrate dehydrogenase [Nitrobacter hamb... 654 0.0
ref|ZP_03977360.1| isocitrate dehydrogenase (NADP(+)) [Bifi... 653 0.0
ref|NP_696658.1| isocitrate dehydrogenase [Bifidobacterium ... 653 0.0
ref|XP_001646579.1| hypothetical protein Kpol_1055p78 [Vand... 653 0.0
ref|YP_883449.1| isocitrate dehydrogenase [Mycobacterium av... 653 0.0
gb|ABD77209.1| isocitrate dehydrogenase 1 [Rattus norvegicus] 653 0.0
sp|P50215|IDH_SPHYA Isocitrate dehydrogenase [NADP] (Oxalos... 653 0.0
ref|XP_001270886.1| isocitrate dehydrogenase Idp1, putative... 653 0.0
ref|NP_594105.1| isocitrate dehydrogenase Idp1 [Schizosacch... 652 0.0
ref|ZP_01448513.1| isocitrate dehydrogenase [alpha proteoba... 652 0.0
ref|YP_266067.1| isocitrate dehydrogenase [Candidatus Pelag... 652 0.0
Sequences not found previously or not previously below threshold:
>ref|XP_847200.1| isocitrate dehydrogenase [NADP], mitochondrial precursor, putative
[Trypanosoma brucei TREU927]
gb|AAX78964.1| isocitrate dehydrogenase [NADP], mitochondrial precursor, putative
[Trypanosoma brucei]
gb|AAZ13134.1| isocitrate dehydrogenase [NADP], mitochondrial precursor, putative
[Trypanosoma brucei]
Length = 437
Score = 763 bits (1971), Expect = 0.0, Method: Composition-based stats.
Identities = 437/437 (100%), Positives = 437/437 (100%)
Query: 1 MFRRVACAASSVNAGALTPRFVSTTRPSLGRIKVSGTVVDMDGDEMTRIIWALIKEKLIL 60
MFRRVACAASSVNAGALTPRFVSTTRPSLGRIKVSGTVVDMDGDEMTRIIWALIKEKLIL
Sbjct: 1 MFRRVACAASSVNAGALTPRFVSTTRPSLGRIKVSGTVVDMDGDEMTRIIWALIKEKLIL 60
Query: 61 PHVDVPIEYYDLSITSRDASNDKVTEQAAEAIQRHNVGIKCATITPDEARVKEFNLKKMW 120
PHVDVPIEYYDLSITSRDASNDKVTEQAAEAIQRHNVGIKCATITPDEARVKEFNLKKMW
Sbjct: 61 PHVDVPIEYYDLSITSRDASNDKVTEQAAEAIQRHNVGIKCATITPDEARVKEFNLKKMW 120
Query: 121 KSPNGTIRNILGGTVFREPIIVKNVPRVVPQWSEPIIVGRHAYGDQYKATESLFPPGRLE 180
KSPNGTIRNILGGTVFREPIIVKNVPRVVPQWSEPIIVGRHAYGDQYKATESLFPPGRLE
Sbjct: 121 KSPNGTIRNILGGTVFREPIIVKNVPRVVPQWSEPIIVGRHAYGDQYKATESLFPPGRLE 180
Query: 181 LVHTPANGGSPQVLEVFNFKGEGVGLAMYNTRESVEAFAESCFEYAIMRRYPLVLSTKNT 240
LVHTPANGGSPQVLEVFNFKGEGVGLAMYNTRESVEAFAESCFEYAIMRRYPLVLSTKNT
Sbjct: 181 LVHTPANGGSPQVLEVFNFKGEGVGLAMYNTRESVEAFAESCFEYAIMRRYPLVLSTKNT 240
Query: 241 ILKKYDGLFLETFQRMYDTKYREQFERLNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDG 300
ILKKYDGLFLETFQRMYDTKYREQFERLNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDG
Sbjct: 241 ILKKYDGLFLETFQRMYDTKYREQFERLNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDG 300
Query: 301 DVQSDIVAQGFGSLGLMTSVLLCPDGKTIESEAAHGTVTRHYREHQKGKETSTNSVASIF 360
DVQSDIVAQGFGSLGLMTSVLLCPDGKTIESEAAHGTVTRHYREHQKGKETSTNSVASIF
Sbjct: 301 DVQSDIVAQGFGSLGLMTSVLLCPDGKTIESEAAHGTVTRHYREHQKGKETSTNSVASIF 360
Query: 361 AWTRGLAHRGKLDGNAPLVEFASSLERATIKTIEGGHMTKDLALCVHGAAALQRSHYETT 420
AWTRGLAHRGKLDGNAPLVEFASSLERATIKTIEGGHMTKDLALCVHGAAALQRSHYETT
Sbjct: 361 AWTRGLAHRGKLDGNAPLVEFASSLERATIKTIEGGHMTKDLALCVHGAAALQRSHYETT 420
Query: 421 EVFIDSVAEELARSVKG 437
EVFIDSVAEELARSVKG
Sbjct: 421 EVFIDSVAEELARSVKG 437
>gb|ABE98244.1| mitochondrial isocitrate dehydrogenase 2-like [Oreochromis
mossambicus]
Length = 452
Score = 712 bits (1838), Expect = 0.0, Method: Composition-based stats.
Identities = 262/440 (59%), Positives = 338/440 (76%), Gaps = 6/440 (1%)
Query: 2 FRRVACAASSVNAGALTPR----FVSTTRPSLGRIKVSGTVVDMDGDEMTRIIWALIKEK 57
R A AA S N L P + + RIKV+ VV+MDGDEMTRIIW IKEK
Sbjct: 11 LSRSAGAAFSRNPAVLAPAANCQTLQQRNYADKRIKVANPVVEMDGDEMTRIIWEFIKEK 70
Query: 58 LILPHVDVPIEYYDLSITSRDASNDKVTEQAAEAIQRHNVGIKCATITPDEARVKEFNLK 117
LIL +VDV ++Y+DL + RD ++D+VT +A A ++++V +KCATITPDEARV+EF LK
Sbjct: 71 LILTNVDVELKYFDLGLPYRDQTDDQVTIDSALATKKYSVAVKCATITPDEARVEEFGLK 130
Query: 118 KMWKSPNGTIRNILGGTVFREPIIVKNVPRVVPQWSEPIIVGRHAYGDQYKATESLF-PP 176
KMWKSPNGTIRNILGGTVFREPII KN+PR+VP W++PI +GRHA+GDQY+AT+ + P
Sbjct: 131 KMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTQPITIGRHAFGDQYRATDFVVDQP 190
Query: 177 GRLELVHTPANGGSPQVLEVFNFKGEGVGLAMYNTRESVEAFAESCFEYAIMRRYPLVLS 236
G+ ++V +PA+G + + EVF+F G G+ MYNT ES+ FA SCF+YAI +++PL +S
Sbjct: 191 GKFKIVFSPADGSTSKEWEVFDFPAGGCGMGMYNTDESITGFAHSCFQYAIGKKWPLYMS 250
Query: 237 TKNTILKKYDGLFLETFQRMYDTKYREQFERLNLTYVHRLIDDQVAQMIKGNGGFVWACK 296
TKNTILK YDG F + FQ +++ Y+ +F++L + Y HRLIDD VAQ++K +G FVWACK
Sbjct: 251 TKNTILKAYDGRFKDIFQDIFEKNYKPEFDKLKIWYEHRLIDDMVAQVLKSSGAFVWACK 310
Query: 297 NYDGDVQSDIVAQGFGSLGLMTSVLLCPDGKTIESEAAHGTVTRHYREHQKGKETSTNSV 356
NYDGDVQSDI+AQGFGSLGLMTSVL+CPDGKTIE+EAAHGTVTRHYREHQKG+ TSTN +
Sbjct: 311 NYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPI 370
Query: 357 ASIFAWTRGLAHRGKLDGNAPLVEFASSLERATIKTIEGGHMTKDLALCVHGAAALQ-RS 415
ASIFAWTRGL HRGKLDGN L++FA +LE+ + T+E G MTKDLA C+HG + ++
Sbjct: 371 ASIFAWTRGLEHRGKLDGNPDLIKFAQTLEQVCVATVESGTMTKDLAGCIHGLSNVKLNE 430
Query: 416 HYETTEVFIDSVAEELARSV 435
HY T F+D++ L +++
Sbjct: 431 HYVNTTDFLDAIKTNLDKAL 450
>gb|ABF20272.1| mitochondrial isocitrate dehydrogenase [Leishmania tropica]
Length = 435
Score = 710 bits (1834), Expect = 0.0, Method: Composition-based stats.
Identities = 322/437 (73%), Positives = 382/437 (87%), Gaps = 2/437 (0%)
Query: 1 MFRRVACAASSVNAGALTPRFVSTTRPSLGRIKVSGTVVDMDGDEMTRIIWALIKEKLIL 60
MFR+V+ A++S + F ST RIKV VVDMDGDEMTRIIW+ IKEKLIL
Sbjct: 1 MFRQVSAASAS--SLVTARSFSSTNVYLDKRIKVKNEVVDMDGDEMTRIIWSFIKEKLIL 58
Query: 61 PHVDVPIEYYDLSITSRDASNDKVTEQAAEAIQRHNVGIKCATITPDEARVKEFNLKKMW 120
P+VDVPI Y+DLS+T+RDA+NDKVT +AAEAI++ NVGIKCATITPDEARVKEFNLKKMW
Sbjct: 59 PYVDVPINYFDLSVTNRDATNDKVTVEAAEAIKKCNVGIKCATITPDEARVKEFNLKKMW 118
Query: 121 KSPNGTIRNILGGTVFREPIIVKNVPRVVPQWSEPIIVGRHAYGDQYKATESLFPPGRLE 180
KSPNGTIRNILGGTVFREPIIV N+PR+VPQW PI+VGRHA+GDQYKAT+++ PG+L+
Sbjct: 119 KSPNGTIRNILGGTVFREPIIVSNIPRIVPQWHNPIVVGRHAFGDQYKATDAVLKPGKLQ 178
Query: 181 LVHTPANGGSPQVLEVFNFKGEGVGLAMYNTRESVEAFAESCFEYAIMRRYPLVLSTKNT 240
LVHTPA+G +P L+V++FKG+GVGLAMYNT+ES+E FA+SCF+YA+MR+YPLVL+TKNT
Sbjct: 179 LVHTPADGSAPTTLDVYDFKGDGVGLAMYNTKESIEGFAKSCFQYALMRKYPLVLTTKNT 238
Query: 241 ILKKYDGLFLETFQRMYDTKYREQFERLNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDG 300
ILKKYDG+FL+TFQRMYD +Y+ FE+ +TY HRLIDDQVAQMIKG GGFVWACKNYDG
Sbjct: 239 ILKKYDGMFLQTFQRMYDEQYKADFEKAGITYNHRLIDDQVAQMIKGEGGFVWACKNYDG 298
Query: 301 DVQSDIVAQGFGSLGLMTSVLLCPDGKTIESEAAHGTVTRHYREHQKGKETSTNSVASIF 360
DVQSDIVAQGFGSLGLMTSVL+CPDGKTIE+EAAHGTVTRHYR+HQ+GKETSTNSVASI+
Sbjct: 299 DVQSDIVAQGFGSLGLMTSVLMCPDGKTIEAEAAHGTVTRHYRQHQQGKETSTNSVASIY 358
Query: 361 AWTRGLAHRGKLDGNAPLVEFASSLERATIKTIEGGHMTKDLALCVHGAAALQRSHYETT 420
AWTRGLAHRGKLDGN+ LV F+ +LER +K IE GHMTKDLALCV+G++ ++R HYETT
Sbjct: 359 AWTRGLAHRGKLDGNSDLVRFSETLERVVVKAIEDGHMTKDLALCVYGSSGVKREHYETT 418
Query: 421 EVFIDSVAEELARSVKG 437
E F+DSV L +++
Sbjct: 419 EQFLDSVDAALKKAMSA 435
>ref|NP_786984.1| isocitrate dehydrogenase 2 (NADP+), mitochondrial [Bos taurus]
emb|CAA49207.1| isocitrate dehydrogenase (NADP+) [Bos taurus]
Length = 452
Score = 710 bits (1833), Expect = 0.0, Method: Composition-based stats.
Identities = 267/442 (60%), Positives = 339/442 (76%), Gaps = 11/442 (2%)
Query: 4 RVACAASSVNAGALTPRFVS--------TTRPSLGRIKVSGTVVDMDGDEMTRIIWALIK 55
R C AS + A PR ++ + RIKV+ VV+MDGDEMTRIIW IK
Sbjct: 9 RSLCRASG-SGSAWAPRALTAPNLQEQPRRHYADKRIKVAKPVVEMDGDEMTRIIWQFIK 67
Query: 56 EKLILPHVDVPIEYYDLSITSRDASNDKVTEQAAEAIQRHNVGIKCATITPDEARVKEFN 115
EKLILPHVDV ++Y+DL + +RD +ND+VT +A A Q+++V +KCATITPDEARV+EF
Sbjct: 68 EKLILPHVDVQLKYFDLGLPNRDQTNDQVTIDSALATQKYSVAVKCATITPDEARVEEFK 127
Query: 116 LKKMWKSPNGTIRNILGGTVFREPIIVKNVPRVVPQWSEPIIVGRHAYGDQYKATESLFP 175
LKKMWKSPNGTIRNILGGTVFREPII KN+PR+VP W++PI +GRHA+GDQYKAT+ +
Sbjct: 128 LKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYKATDFVVD 187
Query: 176 -PGRLELVHTPANGGSPQVLEVFNFKGEGVGLAMYNTRESVEAFAESCFEYAIMRRYPLV 234
G ++V TP +G P+ EV+NF GVG+ MYNT ES+ FA SCF+YAI +++PL
Sbjct: 188 RAGTFKVVFTPKDGSGPKEWEVYNFPAGGVGMGMYNTDESISGFAHSCFQYAIQKKWPLY 247
Query: 235 LSTKNTILKKYDGLFLETFQRMYDTKYREQFERLNLTYVHRLIDDQVAQMIKGNGGFVWA 294
+STKNTILK YDG F + FQ +++ Y+ +F++ + Y HRLIDD VAQ++K +GGFVWA
Sbjct: 248 MSTKNTILKAYDGRFKDIFQAIFEKHYKTEFDKHKIWYEHRLIDDMVAQVLKSSGGFVWA 307
Query: 295 CKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDGKTIESEAAHGTVTRHYREHQKGKETSTN 354
CKNYDGDVQSDI+AQGFGSLGLMTSVL+CPDGKTIE+EAAHGTVTRHYREHQKG+ TSTN
Sbjct: 308 CKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTN 367
Query: 355 SVASIFAWTRGLAHRGKLDGNAPLVEFASSLERATIKTIEGGHMTKDLALCVHGAAALQ- 413
+ASIFAWTRGL HRGKLDGN L+ FA +LE+ ++T+E G MTKDLA C+HG + ++
Sbjct: 368 PIASIFAWTRGLEHRGKLDGNQDLIRFAQTLEKVCVETVESGAMTKDLAGCIHGLSNVKL 427
Query: 414 RSHYETTEVFIDSVAEELARSV 435
H+ T F+D++ L R++
Sbjct: 428 NEHFLNTSDFLDTIKSNLDRAL 449
>ref|NP_955858.1| isocitrate dehydrogenase 2 (NADP+), mitochondrial [Danio rerio]
gb|AAH48041.1| Isocitrate dehydrogenase 2 (NADP+), mitochondrial [Danio rerio]
gb|AAH63967.1| Isocitrate dehydrogenase 2 (NADP+), mitochondrial [Danio rerio]
Length = 449
Score = 708 bits (1828), Expect = 0.0, Method: Composition-based stats.
Identities = 260/434 (59%), Positives = 335/434 (77%), Gaps = 4/434 (0%)
Query: 6 ACAASSVNAGALTPR--FVSTTRPSLGRIKVSGTVVDMDGDEMTRIIWALIKEKLILPHV 63
+ A S + L P + + RI+V+ VV+MDGDEMTRIIW IKEKLIL +V
Sbjct: 14 SAATLSKSPAVLAPACQSLQQRNYADKRIQVAQPVVEMDGDEMTRIIWEFIKEKLILTNV 73
Query: 64 DVPIEYYDLSITSRDASNDKVTEQAAEAIQRHNVGIKCATITPDEARVKEFNLKKMWKSP 123
+V ++YYDL + RD ++D+VT +A A +++NV +KCATITPDEARV+EF LKKMWKSP
Sbjct: 74 NVDLKYYDLGLPYRDQTDDQVTIDSAIATKKYNVAVKCATITPDEARVEEFKLKKMWKSP 133
Query: 124 NGTIRNILGGTVFREPIIVKNVPRVVPQWSEPIIVGRHAYGDQYKATESLF-PPGRLELV 182
NGTIRNILGGTVFREPII KN+PR+VP W++ I +GRHA+GDQYKAT+ + PG+ ++V
Sbjct: 134 NGTIRNILGGTVFREPIICKNIPRLVPGWTQAITIGRHAFGDQYKATDFVVNQPGKFKMV 193
Query: 183 HTPANGGSPQVLEVFNFKGEGVGLAMYNTRESVEAFAESCFEYAIMRRYPLVLSTKNTIL 242
TPA+G + EV++F G G G+ MYNT ES+ FA SCF+YAI +++PL +STKNTIL
Sbjct: 194 FTPADGSKNKEWEVYDFPGGGCGMGMYNTDESITGFAHSCFQYAIQKKWPLYMSTKNTIL 253
Query: 243 KKYDGLFLETFQRMYDTKYREQFERLNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDV 302
K YDG F + FQ +++ Y+ +F++L + Y HRLIDD VAQ++K +G FVWACKNYDGDV
Sbjct: 254 KAYDGRFKDIFQDIFEKNYKPEFDKLKIWYEHRLIDDMVAQVLKSSGAFVWACKNYDGDV 313
Query: 303 QSDIVAQGFGSLGLMTSVLLCPDGKTIESEAAHGTVTRHYREHQKGKETSTNSVASIFAW 362
QSDI+AQGFGSLGLMTSVL+CPDGKTIE+EAAHGTVTRHYREHQKG+ TSTN +ASIFAW
Sbjct: 314 QSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAW 373
Query: 363 TRGLAHRGKLDGNAPLVEFASSLERATIKTIEGGHMTKDLALCVHGAAALQ-RSHYETTE 421
TRGL HRGKLDGN L++F+ +LER ++T+E G MTKDLA C+HG A + HY T
Sbjct: 374 TRGLEHRGKLDGNPDLIKFSQTLERVCVETVESGVMTKDLAGCIHGLANCKLNEHYVNTT 433
Query: 422 VFIDSVAEELARSV 435
F+D++ L +++
Sbjct: 434 DFLDAIKTNLDKAL 447
>sp|Q04467|IDHP_BOVIN Isocitrate dehydrogenase [NADP], mitochondrial precursor
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) (IDP) (ICD-M)
gb|AAI02510.1| Isocitrate dehydrogenase 2 (NADP+), mitochondrial [Bos taurus]
Length = 452
Score = 708 bits (1827), Expect = 0.0, Method: Composition-based stats.
Identities = 266/442 (60%), Positives = 338/442 (76%), Gaps = 11/442 (2%)
Query: 4 RVACAASSVNAGALTPRFVS--------TTRPSLGRIKVSGTVVDMDGDEMTRIIWALIK 55
R C AS + A P ++ + RIKV+ VV+MDGDEMTRIIW IK
Sbjct: 9 RSLCRASG-SGSAWAPAALTAPNLQEQPRRHYADKRIKVAKPVVEMDGDEMTRIIWQFIK 67
Query: 56 EKLILPHVDVPIEYYDLSITSRDASNDKVTEQAAEAIQRHNVGIKCATITPDEARVKEFN 115
EKLILPHVDV ++Y+DL + +RD +ND+VT +A A Q+++V +KCATITPDEARV+EF
Sbjct: 68 EKLILPHVDVQLKYFDLGLPNRDQTNDQVTIDSALATQKYSVAVKCATITPDEARVEEFK 127
Query: 116 LKKMWKSPNGTIRNILGGTVFREPIIVKNVPRVVPQWSEPIIVGRHAYGDQYKATESLFP 175
LKKMWKSPNGTIRNILGGTVFREPII KN+PR+VP W++PI +GRHA+GDQYKAT+ +
Sbjct: 128 LKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYKATDFVVD 187
Query: 176 -PGRLELVHTPANGGSPQVLEVFNFKGEGVGLAMYNTRESVEAFAESCFEYAIMRRYPLV 234
G ++V TP +G P+ EV+NF GVG+ MYNT ES+ FA SCF+YAI +++PL
Sbjct: 188 RAGTFKVVFTPKDGSGPKEWEVYNFPAGGVGMGMYNTDESISGFAHSCFQYAIQKKWPLY 247
Query: 235 LSTKNTILKKYDGLFLETFQRMYDTKYREQFERLNLTYVHRLIDDQVAQMIKGNGGFVWA 294
+STKNTILK YDG F + FQ +++ Y+ +F++ + Y HRLIDD VAQ++K +GGFVWA
Sbjct: 248 MSTKNTILKAYDGRFKDIFQAIFEKHYKTEFDKHKIWYEHRLIDDMVAQVLKSSGGFVWA 307
Query: 295 CKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDGKTIESEAAHGTVTRHYREHQKGKETSTN 354
CKNYDGDVQSDI+AQGFGSLGLMTSVL+CPDGKTIE+EAAHGTVTRHYREHQKG+ TSTN
Sbjct: 308 CKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTN 367
Query: 355 SVASIFAWTRGLAHRGKLDGNAPLVEFASSLERATIKTIEGGHMTKDLALCVHGAAALQ- 413
+ASIFAWTRGL HRGKLDGN L+ FA +LE+ ++T+E G MTKDLA C+HG + ++
Sbjct: 368 PIASIFAWTRGLEHRGKLDGNQDLIRFAQTLEKVCVETVESGAMTKDLAGCIHGLSNVKL 427
Query: 414 RSHYETTEVFIDSVAEELARSV 435
H+ T F+D++ L R++
Sbjct: 428 NEHFLNTSDFLDTIKSNLDRAL 449
>gb|ACO14046.1| Isocitrate dehydrogenase, mitochondrial precursor [Esox lucius]
Length = 451
Score = 707 bits (1825), Expect = 0.0, Method: Composition-based stats.
Identities = 264/436 (60%), Positives = 332/436 (76%), Gaps = 6/436 (1%)
Query: 6 ACAASSVNAGALTPRF----VSTTRPSLGRIKVSGTVVDMDGDEMTRIIWALIKEKLILP 61
+ A S + L P + RIKVS VV+MDGDEMTRIIW IKEKLIL
Sbjct: 14 SAATFSKSPAVLAPVSTCPSLQQRNYGDKRIKVSQPVVEMDGDEMTRIIWEFIKEKLILS 73
Query: 62 HVDVPIEYYDLSITSRDASNDKVTEQAAEAIQRHNVGIKCATITPDEARVKEFNLKKMWK 121
+VDV ++YYDL + RD +ND+VT +A A Q+++V +KCATITPDEARV+EF LKKMWK
Sbjct: 74 NVDVELKYYDLGLPYRDQTNDQVTIDSALATQKYHVAVKCATITPDEARVEEFKLKKMWK 133
Query: 122 SPNGTIRNILGGTVFREPIIVKNVPRVVPQWSEPIIVGRHAYGDQYKATESLF-PPGRLE 180
SPNGTIRNILGGTVFREPII KN+PR+VP W++PI +GRHA+GDQY+AT+ + PG +
Sbjct: 134 SPNGTIRNILGGTVFREPIICKNIPRLVPGWTQPITIGRHAFGDQYRATDFVVNQPGTFK 193
Query: 181 LVHTPANGGSPQVLEVFNFKGEGVGLAMYNTRESVEAFAESCFEYAIMRRYPLVLSTKNT 240
+V +P +G Q V+NF G G G+ MYNT ES+ FA SCF+YAI +++PL LSTKNT
Sbjct: 194 MVFSPTDGSKGQEWGVYNFPGGGCGMGMYNTDESISGFAHSCFQYAIGKKWPLYLSTKNT 253
Query: 241 ILKKYDGLFLETFQRMYDTKYREQFERLNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDG 300
ILK YDG F + F+ ++ Y+ +F++L + Y HRLIDD VAQ++K +G FVWACKNYDG
Sbjct: 254 ILKAYDGRFKDIFEEIFQANYKPEFDKLKIWYEHRLIDDMVAQVLKSDGAFVWACKNYDG 313
Query: 301 DVQSDIVAQGFGSLGLMTSVLLCPDGKTIESEAAHGTVTRHYREHQKGKETSTNSVASIF 360
DVQSDI+AQGFGSLGLMTSVL+CPDGKTIE+EAAHGTVTRHYREHQKG TSTN +ASIF
Sbjct: 314 DVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGNPTSTNPIASIF 373
Query: 361 AWTRGLAHRGKLDGNAPLVEFASSLERATIKTIEGGHMTKDLALCVHGAAALQ-RSHYET 419
AWTRGL HRGKLDGN L++FA +LER ++T+E G MTKDLA C+HG + + HY
Sbjct: 374 AWTRGLEHRGKLDGNPDLIKFALTLERVCVETVESGVMTKDLAGCIHGLSKCKLNEHYVN 433
Query: 420 TEVFIDSVAEELARSV 435
TE F+D++ + L +++
Sbjct: 434 TEDFLDAIKKNLDKAL 449
>ref|NP_970434.1| isocitrate dehydrogenase [Bdellovibrio bacteriovorus HD100]
emb|CAE81088.1| isocitrate dehydrogenase (NADP) [Bdellovibrio bacteriovorus HD100]
Length = 409
Score = 706 bits (1824), Expect = 0.0, Method: Composition-based stats.
Identities = 258/408 (63%), Positives = 322/408 (78%), Gaps = 2/408 (0%)
Query: 29 LGRIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQA 88
+ +IKV+ VV++DGDEMTRIIW IK++LILP++D+ I+YYDL + RDA+ND+VT A
Sbjct: 1 MKKIKVANPVVELDGDEMTRIIWKFIKQQLILPYLDIDIKYYDLGMEHRDATNDQVTVDA 60
Query: 89 AEAIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRV 148
AEAI+++NVGIKCATITPDEARVKEFNLK+MWKSPNGTIRNIL GTVFREPII KNVPR+
Sbjct: 61 AEAIKKYNVGIKCATITPDEARVKEFNLKQMWKSPNGTIRNILDGTVFREPIICKNVPRL 120
Query: 149 VPQWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNFKGEGVGLA 207
VP W+ PI +GRHA+GDQY+AT+ + G+L + P NGG EV+NFKG+GV L
Sbjct: 121 VPNWTAPICIGRHAFGDQYRATDFVTKGKGKLTVTFQPENGGETITHEVYNFKGDGVALT 180
Query: 208 MYNTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFER 267
MYNT ES+ FA SCF A+ +++PL LSTKNTILKKYDG F + F+ +Y +++ +F+
Sbjct: 181 MYNTDESITGFARSCFNQALTKKWPLYLSTKNTILKKYDGRFKDIFEEIYQKEFKAKFDA 240
Query: 268 LNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDGK 327
+TY HRLIDD VA +K NG FVWACKNYDGDVQSD VAQGFGSLGLMTSVL+ PDGK
Sbjct: 241 AGITYEHRLIDDMVASALKWNGNFVWACKNYDGDVQSDTVAQGFGSLGLMTSVLVTPDGK 300
Query: 328 TIESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLER 387
T+ESEAAHGTVTRHYR+HQ+GK TSTN +ASIFAWTRGL HRG LD N LV+FA +LE+
Sbjct: 301 TMESEAAHGTVTRHYRQHQQGKPTSTNPIASIFAWTRGLEHRGNLDNNQELVKFAQTLEK 360
Query: 388 ATIKTIEGGHMTKDLALCVHGAAALQRSHYETTEVFIDSVAEELARSV 435
++T+E G MTKDLA+C++G + Y TE F+ + E L +++
Sbjct: 361 VCVETVEAGFMTKDLAVCIYGD-KVPADKYMNTEPFLAKLDENLKKAL 407
>ref|NP_001026770.1| hypothetical protein LOC431056 [Gallus gallus]
emb|CAG31511.1| hypothetical protein [Gallus gallus]
Length = 452
Score = 705 bits (1819), Expect = 0.0, Method: Composition-based stats.
Identities = 260/407 (63%), Positives = 329/407 (80%), Gaps = 2/407 (0%)
Query: 31 RIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQAAE 90
RIKV+ VV+MDGDEMTRIIWA IKEKLILP+VDV ++Y+DL + RD ++D+VT +A
Sbjct: 43 RIKVANPVVEMDGDEMTRIIWAFIKEKLILPNVDVQLKYFDLGLPHRDKTDDQVTIDSAL 102
Query: 91 AIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRVVP 150
A ++++V +KCATITPDEARV+EF LKKMWKSPNGTIRNILGGTVFREPII KN+PR+VP
Sbjct: 103 ATKKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVP 162
Query: 151 QWSEPIIVGRHAYGDQYKATESLFPP-GRLELVHTPANGGSPQVLEVFNFKGEGVGLAMY 209
W++PI +GRHA+GDQYKAT+ + G ++V TP +G + EVFNF G GVG+ MY
Sbjct: 163 GWTQPITIGRHAHGDQYKATDFVVNKSGTFKMVFTPKDGSGVKEWEVFNFPGGGVGMGMY 222
Query: 210 NTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFERLN 269
NT ES+ FA SCF+YAI +++PL +STKNTILK YDG F + FQ ++D Y+ +F++L
Sbjct: 223 NTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTEFDKLK 282
Query: 270 LTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDGKTI 329
+ Y HRLIDD VAQ++K +GGFVWACKNYDGDVQSDI+AQGFGSLGLMTSVL+CPDGKTI
Sbjct: 283 IWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTI 342
Query: 330 ESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLERAT 389
E+EAAHGTVTRHYREHQKG+ TSTN +ASIFAWTRGL HRGKLD N L++FA +LE+
Sbjct: 343 EAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDSNPELIKFAQTLEKVC 402
Query: 390 IKTIEGGHMTKDLALCVHGAAALQ-RSHYETTEVFIDSVAEELARSV 435
++T+E G MTKDLA C+HG A ++ H+ T F+D++ L +++
Sbjct: 403 VETVESGTMTKDLAGCIHGLANVKLNEHFVNTTDFLDAIKNTLDKAL 449
>ref|XP_001095686.1| PREDICTED: isocitrate dehydrogenase 2 (NADP+), mitochondrial
[Macaca mulatta]
sp|Q4R502|IDHP_MACFA Isocitrate dehydrogenase [NADP], mitochondrial precursor
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) (IDP) (ICD-M)
dbj|BAE01823.1| unnamed protein product [Macaca fascicularis]
Length = 452
Score = 703 bits (1816), Expect = 0.0, Method: Composition-based stats.
Identities = 264/441 (59%), Positives = 335/441 (75%), Gaps = 9/441 (2%)
Query: 4 RVACAASSVNAG-------ALTPRFVSTTRPSLGRIKVSGTVVDMDGDEMTRIIWALIKE 56
R C AS A T + + + RIKV+ VV+MDGDEMTRIIW IKE
Sbjct: 9 RSLCRASGSRPAWAPAALTAPTSQEQTRRHYADKRIKVAKPVVEMDGDEMTRIIWQFIKE 68
Query: 57 KLILPHVDVPIEYYDLSITSRDASNDKVTEQAAEAIQRHNVGIKCATITPDEARVKEFNL 116
KLILPHVD+ ++Y+DL + +RD ++D+VT +A A Q+++V +KCATITPDEARV+EF L
Sbjct: 69 KLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDEARVEEFKL 128
Query: 117 KKMWKSPNGTIRNILGGTVFREPIIVKNVPRVVPQWSEPIIVGRHAYGDQYKATESLFP- 175
KKMWKSPNGTIRNILGGTVFREPII KN+PR+VP W++PI +GRHA+GDQYKAT+ +
Sbjct: 129 KKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYKATDFVADR 188
Query: 176 PGRLELVHTPANGGSPQVLEVFNFKGEGVGLAMYNTRESVEAFAESCFEYAIMRRYPLVL 235
G ++V TP +G + EV+NF GVG+ MYNT ES+ FA SCF+YAI +++PL +
Sbjct: 189 AGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMYNTDESISGFAHSCFQYAIQKKWPLYM 248
Query: 236 STKNTILKKYDGLFLETFQRMYDTKYREQFERLNLTYVHRLIDDQVAQMIKGNGGFVWAC 295
STKNTILK YDG F + FQ ++D Y+ F++ + Y HRLIDD VAQ++K +GGFVWAC
Sbjct: 249 STKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKSSGGFVWAC 308
Query: 296 KNYDGDVQSDIVAQGFGSLGLMTSVLLCPDGKTIESEAAHGTVTRHYREHQKGKETSTNS 355
KNYDGDVQSDI+AQGFGSLGLMTSVL+CPDGKTIE+EAAHGTVTRHYREHQKG+ TSTN
Sbjct: 309 KNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNP 368
Query: 356 VASIFAWTRGLAHRGKLDGNAPLVEFASSLERATIKTIEGGHMTKDLALCVHGAAALQ-R 414
+ASIFAWTRGL HRGKLDGN L+ FA +LE+ ++T+E G MTKDLA C+HG + ++
Sbjct: 369 IASIFAWTRGLEHRGKLDGNQDLIRFAQTLEKVCVETVESGAMTKDLAGCIHGLSNVKLN 428
Query: 415 SHYETTEVFIDSVAEELARSV 435
H+ T F+D++ L R++
Sbjct: 429 EHFLNTTDFLDTIKSNLDRAL 449
>ref|XP_001369305.1| PREDICTED: hypothetical protein [Monodelphis domestica]
Length = 455
Score = 703 bits (1816), Expect = 0.0, Method: Composition-based stats.
Identities = 260/407 (63%), Positives = 324/407 (79%), Gaps = 2/407 (0%)
Query: 31 RIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQAAE 90
RIKV VV+MDGDEMTRIIW IKEKLILPHVDV ++Y+DL + RD ++D+VT +A
Sbjct: 46 RIKVDKPVVEMDGDEMTRIIWQFIKEKLILPHVDVQLKYFDLGLPHRDQTDDQVTIDSAL 105
Query: 91 AIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRVVP 150
A Q+++V +KCATITPDEARV+EF LKKMWKSPNGTIRNILGGTVFREPII KN+PR+VP
Sbjct: 106 ATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVP 165
Query: 151 QWSEPIIVGRHAYGDQYKATESLF-PPGRLELVHTPANGGSPQVLEVFNFKGEGVGLAMY 209
W+ PI +GRHA+GDQYKAT+ + G ++V TP +G + EV+NF GVG+ MY
Sbjct: 166 GWTRPITIGRHAHGDQYKATDFVVDKAGTFKMVFTPKDGSGAKEWEVYNFPAGGVGMGMY 225
Query: 210 NTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFERLN 269
NT ES+ FA SCF+YAI +++PL +STKNTILK YDG F + FQ ++D Y+ F++
Sbjct: 226 NTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNK 285
Query: 270 LTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDGKTI 329
+ Y HRLIDD VAQ++K NGGFVWACKNYDGDVQSDI+AQGFGSLGLMTSVL+CPDGKTI
Sbjct: 286 IWYEHRLIDDMVAQVLKSNGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTI 345
Query: 330 ESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLERAT 389
E+EAAHGTVTRHYREHQKG+ TSTN +ASIFAWTRGL HRGKLDGN L++FA +LE+
Sbjct: 346 EAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIKFAQTLEKVC 405
Query: 390 IKTIEGGHMTKDLALCVHGAAALQ-RSHYETTEVFIDSVAEELARSV 435
++T+E G MTKDLA C+HG + ++ HY T F+D++ L +++
Sbjct: 406 VQTVESGAMTKDLAGCIHGLSNVKLNEHYLNTGDFLDTIKNNLDKAL 452
>ref|XP_510589.2| PREDICTED: isocitrate dehydrogenase 2 (NADP+), mitochondrial
isoform 4 [Pan troglodytes]
Length = 452
Score = 703 bits (1816), Expect = 0.0, Method: Composition-based stats.
Identities = 262/441 (59%), Positives = 332/441 (75%), Gaps = 9/441 (2%)
Query: 4 RVACAASSVNAGALTPRFVS-------TTRPSLGRIKVSGTVVDMDGDEMTRIIWALIKE 56
R C AS + + RIKV+ VV+MDGDEMTRIIW IKE
Sbjct: 9 RSLCRASGSRPAWAPAALTAPTSQEQPRRHYADKRIKVAKPVVEMDGDEMTRIIWQFIKE 68
Query: 57 KLILPHVDVPIEYYDLSITSRDASNDKVTEQAAEAIQRHNVGIKCATITPDEARVKEFNL 116
KLILPHVD+ ++Y+DL + +RD ++D+VT +A A Q+++V +KCATITPDEARV+EF L
Sbjct: 69 KLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDEARVEEFKL 128
Query: 117 KKMWKSPNGTIRNILGGTVFREPIIVKNVPRVVPQWSEPIIVGRHAYGDQYKATESLFP- 175
KKMWKSPNGTIRNILGGTVFREPII KN+PR+VP W++PI +GRHA+GDQYKAT+ +
Sbjct: 129 KKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYKATDFVADR 188
Query: 176 PGRLELVHTPANGGSPQVLEVFNFKGEGVGLAMYNTRESVEAFAESCFEYAIMRRYPLVL 235
G ++V TP +G + EV+NF GVG+ MYNT ES+ FA SCF+YAI +++PL +
Sbjct: 189 AGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMYNTDESISGFAHSCFQYAIQKKWPLYM 248
Query: 236 STKNTILKKYDGLFLETFQRMYDTKYREQFERLNLTYVHRLIDDQVAQMIKGNGGFVWAC 295
STKNTILK YDG F + FQ ++D Y+ F++ + Y HRLIDD VAQ++K +GGFVWAC
Sbjct: 249 STKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKSSGGFVWAC 308
Query: 296 KNYDGDVQSDIVAQGFGSLGLMTSVLLCPDGKTIESEAAHGTVTRHYREHQKGKETSTNS 355
KNYDGDVQSDI+AQGFGSLGLMTSVL+CPDGKTIE+EAAHGTVTRHYREHQKG+ TSTN
Sbjct: 309 KNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNP 368
Query: 356 VASIFAWTRGLAHRGKLDGNAPLVEFASSLERATIKTIEGGHMTKDLALCVHGAAALQ-R 414
+ASIFAWTRGL HRGKLDGN L+ FA +LE+ ++T+E G MTKDLA C+HG + ++
Sbjct: 369 IASIFAWTRGLEHRGKLDGNQDLIRFAQTLEKVCVETVESGAMTKDLAGCIHGLSNVKLN 428
Query: 415 SHYETTEVFIDSVAEELARSV 435
H+ T F+D++ L R++
Sbjct: 429 EHFLNTTDFLDTIKSNLDRAL 449
>ref|XP_536192.2| PREDICTED: similar to isocitrate dehydrogenase 2 (NADP+),
mitochondrial [Canis familiaris]
Length = 517
Score = 703 bits (1815), Expect = 0.0, Method: Composition-based stats.
Identities = 257/407 (63%), Positives = 327/407 (80%), Gaps = 2/407 (0%)
Query: 31 RIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQAAE 90
RIKV+ VV+MDGDEMTRIIW IKEKLILPHVDV ++Y+DL + +RD +ND+VT +A
Sbjct: 109 RIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDVQLKYFDLGLPNRDQTNDQVTIDSAL 168
Query: 91 AIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRVVP 150
A Q+++V +KCATITPDEARV+EF LKKMWKSPNGTIRNILGGTVFREPII KN+PR+VP
Sbjct: 169 ATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVP 228
Query: 151 QWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNFKGEGVGLAMY 209
W++PI +GRHA+GDQYKAT+ + G +++ +P +G + EV+NF G GVG+ MY
Sbjct: 229 GWTKPITIGRHAHGDQYKATDFVVDRAGTFKIIFSPKDGSGAKEWEVYNFPGGGVGMGMY 288
Query: 210 NTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFERLN 269
NT ES+ FA SCF+YAI +++PL +STKNTILK YDG F + FQ +++ Y+ F++
Sbjct: 289 NTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFEKHYKTDFDKNK 348
Query: 270 LTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDGKTI 329
+ Y HRLIDD VAQ++K +GGFVWACKNYDGDVQSDI+AQGFGSLGLMTSVL+CPDGKTI
Sbjct: 349 IWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTI 408
Query: 330 ESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLERAT 389
E+EAAHGTVTRHYREHQKG+ TSTN +ASIFAWTRGL HRGKLDGN L+ FA +LE+
Sbjct: 409 EAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQTLEKVC 468
Query: 390 IKTIEGGHMTKDLALCVHGAAALQ-RSHYETTEVFIDSVAEELARSV 435
++T+E G MTKDLA C+HG + ++ H+ T F+D++ L +++
Sbjct: 469 VQTVESGAMTKDLAGCIHGLSNVKLNEHFLNTSDFLDTIKNNLDKAL 515
>sp|P54071|IDHP_MOUSE Isocitrate dehydrogenase [NADP], mitochondrial precursor
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) (IDP) (ICD-M)
dbj|BAC40149.1| unnamed protein product [Mus musculus]
gb|AAH60030.1| Isocitrate dehydrogenase 2 (NADP+), mitochondrial [Mus musculus]
dbj|BAE41142.1| unnamed protein product [Mus musculus]
dbj|BAE36505.1| unnamed protein product [Mus musculus]
dbj|BAE26628.1| unnamed protein product [Mus musculus]
gb|EDL07035.1| isocitrate dehydrogenase 2 (NADP+), mitochondrial, isoform CRA_d
[Mus musculus]
Length = 452
Score = 703 bits (1815), Expect = 0.0, Method: Composition-based stats.
Identities = 262/407 (64%), Positives = 326/407 (80%), Gaps = 2/407 (0%)
Query: 31 RIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQAAE 90
RIKV VV+MDGDEMTRIIW IKEKLILPHVDV ++Y+DL + +RD +ND+VT +A
Sbjct: 43 RIKVEKPVVEMDGDEMTRIIWQFIKEKLILPHVDVQLKYFDLGLPNRDQTNDQVTIDSAL 102
Query: 91 AIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRVVP 150
A Q+++V +KCATITPDEARV+EF LKKMWKSPNGTIRNILGGTVFREPII KN+PR+VP
Sbjct: 103 ATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVP 162
Query: 151 QWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNFKGEGVGLAMY 209
W++PI +GRHA+GDQYKAT+ + G +LV TP +G S + EV+NF GVG+ MY
Sbjct: 163 GWTKPITIGRHAHGDQYKATDFVVDRAGTFKLVFTPKDGSSAKEWEVYNFPAGGVGMGMY 222
Query: 210 NTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFERLN 269
NT ES+ FA SCF+Y+I +++PL LSTKNTILK YDG F + FQ ++D Y+ F++
Sbjct: 223 NTDESISGFAHSCFQYSIQKKWPLYLSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNK 282
Query: 270 LTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDGKTI 329
+ Y HRLIDD VAQ++K +GGFVWACKNYDGDVQSDI+AQGFGSLGLMTSVL+CPDGKTI
Sbjct: 283 IWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTI 342
Query: 330 ESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLERAT 389
E+EAAHGTVTRHYREHQKG+ TSTN +ASIFAWTRGL HRGKLDGN L+ FA +LE+
Sbjct: 343 EAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQTLEKVC 402
Query: 390 IKTIEGGHMTKDLALCVHGAAALQ-RSHYETTEVFIDSVAEELARSV 435
++T+E G MTKDLA C+HG + ++ H+ T F+D++ L R++
Sbjct: 403 VQTVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRAL 449
>ref|NP_002159.2| isocitrate dehydrogenase 2 (NADP+), mitochondrial precursor [Homo
sapiens]
sp|P48735|IDHP_HUMAN Isocitrate dehydrogenase [NADP], mitochondrial precursor
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) (IDP) (ICD-M)
gb|AAH09244.1| Isocitrate dehydrogenase 2 (NADP+), mitochondrial [Homo sapiens]
gb|AAH71828.1| Isocitrate dehydrogenase 2 (NADP+), mitochondrial [Homo sapiens]
gb|EAX02082.1| isocitrate dehydrogenase 2 (NADP+), mitochondrial, isoform CRA_a
[Homo sapiens]
gb|ABM83743.1| isocitrate dehydrogenase 2 (NADP+), mitochondrial [synthetic
construct]
gb|ABM87062.1| isocitrate dehydrogenase 2 (NADP+), mitochondrial [synthetic
construct]
Length = 452
Score = 702 bits (1813), Expect = 0.0, Method: Composition-based stats.
Identities = 262/441 (59%), Positives = 331/441 (75%), Gaps = 9/441 (2%)
Query: 4 RVACAASSVNAGALTPRFVS-------TTRPSLGRIKVSGTVVDMDGDEMTRIIWALIKE 56
R C AS + + RIKV+ VV+MDGDEMTRIIW IKE
Sbjct: 9 RSLCRASGSRPAWAPAALTAPTSQEQPRRHYADKRIKVAKPVVEMDGDEMTRIIWQFIKE 68
Query: 57 KLILPHVDVPIEYYDLSITSRDASNDKVTEQAAEAIQRHNVGIKCATITPDEARVKEFNL 116
KLILPHVD+ ++Y+DL + +RD ++D+VT +A A Q+++V +KCATITPDEARV+EF L
Sbjct: 69 KLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDEARVEEFKL 128
Query: 117 KKMWKSPNGTIRNILGGTVFREPIIVKNVPRVVPQWSEPIIVGRHAYGDQYKATESLFP- 175
KKMWKSPNGTIRNILGGTVFREPII KN+PR+VP W++PI +GRHA+GDQYKAT+ +
Sbjct: 129 KKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYKATDFVADR 188
Query: 176 PGRLELVHTPANGGSPQVLEVFNFKGEGVGLAMYNTRESVEAFAESCFEYAIMRRYPLVL 235
G ++V TP +G + EV+NF GVG+ MYNT ES+ FA SCF+YAI +++PL +
Sbjct: 189 AGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMYNTDESISGFAHSCFQYAIQKKWPLYM 248
Query: 236 STKNTILKKYDGLFLETFQRMYDTKYREQFERLNLTYVHRLIDDQVAQMIKGNGGFVWAC 295
STKNTILK YDG F + FQ ++D Y+ F++ + Y HRLIDD VAQ++K +GGFVWAC
Sbjct: 249 STKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKSSGGFVWAC 308
Query: 296 KNYDGDVQSDIVAQGFGSLGLMTSVLLCPDGKTIESEAAHGTVTRHYREHQKGKETSTNS 355
KNYDGDVQSDI+AQGFGSLGLMTSVL+CPDGKTIE+EAAHGTVTRHYREHQKG+ TSTN
Sbjct: 309 KNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNP 368
Query: 356 VASIFAWTRGLAHRGKLDGNAPLVEFASSLERATIKTIEGGHMTKDLALCVHGAAALQ-R 414
+ASIFAWTRGL HRGKLDGN L+ FA LE+ ++T+E G MTKDLA C+HG + ++
Sbjct: 369 IASIFAWTRGLEHRGKLDGNQDLIRFAQMLEKVCVETVESGAMTKDLAGCIHGLSNVKLN 428
Query: 415 SHYETTEVFIDSVAEELARSV 435
H+ T F+D++ L R++
Sbjct: 429 EHFLNTTDFLDTIKSNLDRAL 449
>ref|NP_766599.1| isocitrate dehydrogenase 2 (NADP+), mitochondrial [Mus musculus]
gb|AAG43538.1|AF212319_1 NADP+-specific isocitrate dehydrogenase [Mus musculus]
Length = 452
Score = 701 bits (1811), Expect = 0.0, Method: Composition-based stats.
Identities = 263/407 (64%), Positives = 326/407 (80%), Gaps = 2/407 (0%)
Query: 31 RIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQAAE 90
RIKV VV+MDGDEMTRIIW IKEKLILPHVDV ++Y+DL + +RD +ND+VT +A
Sbjct: 43 RIKVEKPVVEMDGDEMTRIIWQFIKEKLILPHVDVQLKYFDLGLPNRDQTNDQVTIDSAL 102
Query: 91 AIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRVVP 150
A Q+++V +KCATITPDEARV+EF LKKMWKSPNGTIRNILGGTVFREPII KN+PR+VP
Sbjct: 103 ATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVP 162
Query: 151 QWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNFKGEGVGLAMY 209
W++PI +GRHA+GDQYKAT+ + G +LV TP +G S + EV+NF GVG+ MY
Sbjct: 163 GWTKPITIGRHAHGDQYKATDFVVDRAGTFKLVFTPKDGSSAKEWEVYNFPAGGVGMGMY 222
Query: 210 NTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFERLN 269
NT ES+ FA SCF+Y+I +++PL LSTKNTILK YDG F + FQ ++D Y+ F+R
Sbjct: 223 NTDESISGFAHSCFQYSIQKKWPLYLSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDRNK 282
Query: 270 LTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDGKTI 329
+ Y HRLIDD VAQ++K +GGFVWACKNYDGDVQSDI+AQGFGSLGLMTSVL+CPDGKTI
Sbjct: 283 IWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTI 342
Query: 330 ESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLERAT 389
E+EAAHGTVTRHYREHQKG+ TSTN +ASIFAWTRGL HRGKLDGN L+ FA +LE+
Sbjct: 343 EAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQTLEKVC 402
Query: 390 IKTIEGGHMTKDLALCVHGAAALQ-RSHYETTEVFIDSVAEELARSV 435
++T+E G MTKDLA C+HG + ++ H+ T F+D++ L R++
Sbjct: 403 VQTVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRAL 449
>emb|CAA49208.1| isocitrate dehydrogenase (NADP+) [Homo sapiens]
Length = 452
Score = 701 bits (1810), Expect = 0.0, Method: Composition-based stats.
Identities = 262/441 (59%), Positives = 331/441 (75%), Gaps = 9/441 (2%)
Query: 4 RVACAASSVNAGALTPRFVS-------TTRPSLGRIKVSGTVVDMDGDEMTRIIWALIKE 56
R C AS + + RIKV+ VV+MDGDEMTRIIW IKE
Sbjct: 9 RSLCRASGSRPAWAPAALTAPTSQEHPRRHYADKRIKVAKPVVEMDGDEMTRIIWQFIKE 68
Query: 57 KLILPHVDVPIEYYDLSITSRDASNDKVTEQAAEAIQRHNVGIKCATITPDEARVKEFNL 116
KLILPHVD+ ++Y+DL + +RD ++D+VT +A A Q+++V +KCATITPDEARV+EF L
Sbjct: 69 KLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDEARVEEFKL 128
Query: 117 KKMWKSPNGTIRNILGGTVFREPIIVKNVPRVVPQWSEPIIVGRHAYGDQYKATESLFP- 175
KKMWKSPNGTIRNILGGTVFREPII KN+PR+VP W++PI +GRHA+GDQYKAT+ +
Sbjct: 129 KKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYKATDFVADR 188
Query: 176 PGRLELVHTPANGGSPQVLEVFNFKGEGVGLAMYNTRESVEAFAESCFEYAIMRRYPLVL 235
G ++V TP +G + EV+NF GVG+ MYNT ES+ FA SCF+YAI +++PL +
Sbjct: 189 AGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMYNTDESISGFAHSCFQYAIQKKWPLYM 248
Query: 236 STKNTILKKYDGLFLETFQRMYDTKYREQFERLNLTYVHRLIDDQVAQMIKGNGGFVWAC 295
STKNTILK YDG F + FQ ++D Y+ F++ + Y HRLIDD VAQ++K +GGFVWAC
Sbjct: 249 STKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKSSGGFVWAC 308
Query: 296 KNYDGDVQSDIVAQGFGSLGLMTSVLLCPDGKTIESEAAHGTVTRHYREHQKGKETSTNS 355
KNYDGDVQSDI+AQGFGSLGLMTSVL+CPDGKTIE+EAAHGTVTRHYREHQKG+ TSTN
Sbjct: 309 KNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNP 368
Query: 356 VASIFAWTRGLAHRGKLDGNAPLVEFASSLERATIKTIEGGHMTKDLALCVHGAAALQ-R 414
+ASIFAWTRGL HRGKLDGN L+ FA LE+ ++T+E G MTKDLA C+HG + ++
Sbjct: 369 IASIFAWTRGLEHRGKLDGNQDLIRFAQMLEKVCVETVESGAMTKDLAGCIHGLSNVKLN 428
Query: 415 SHYETTEVFIDSVAEELARSV 435
H+ T F+D++ L R++
Sbjct: 429 EHFLNTMDFLDTIKSNLDRAL 449
>dbj|BAC77065.1| NADP-specific isocitrate dehydrogenase [Lupinus albus]
Length = 485
Score = 701 bits (1809), Expect = 0.0, Method: Composition-based stats.
Identities = 254/413 (61%), Positives = 325/413 (78%), Gaps = 2/413 (0%)
Query: 25 TRPSLGRIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKV 84
T P+ R++V +V+MDGDEMTRIIW +IK+KLI P++D+ I+Y+DL + +RDA++D+V
Sbjct: 68 THPNFHRLQVLNPIVEMDGDEMTRIIWKMIKDKLIFPYLDLNIKYFDLGVENRDATDDRV 127
Query: 85 TEQAAEAIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKN 144
T ++AEA ++NV +KCATITPDE RVKEF LK MW+SPNGTIRNIL GTVFREPII +N
Sbjct: 128 TVESAEATLKYNVAVKCATITPDETRVKEFGLKSMWRSPNGTIRNILNGTVFREPIICRN 187
Query: 145 VPRVVPQWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNFKGEG 203
+PR+VP W +PI +GRHA+GDQY+AT+++ PG+L+LV P +G +P L+V++FKG G
Sbjct: 188 IPRIVPGWKKPICIGRHAFGDQYRATDAIIKGPGKLKLVFVPEDGEAPTELDVYDFKGPG 247
Query: 204 VGLAMYNTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYRE 263
V LAMYN ES+ AFAES A +++PL LSTKNTILKKYDG F + FQ +Y+ ++R+
Sbjct: 248 VALAMYNIDESIRAFAESSMSLAFAKKWPLYLSTKNTILKKYDGRFKDIFQEVYEERWRQ 307
Query: 264 QFERLNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLC 323
FE ++ Y HRLIDD VA +K GG+VWACKNYDGDVQSD++AQGFGSLGLMTSVLL
Sbjct: 308 NFEEHSIWYEHRLIDDMVAYAVKSEGGYVWACKNYDGDVQSDLLAQGFGSLGLMTSVLLS 367
Query: 324 PDGKTIESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFAS 383
DGKT+E+EAAHGTVTRH+R HQKG+ETSTNS+ASIFAWTRGL HR KLD N L +F
Sbjct: 368 SDGKTLEAEAAHGTVTRHFRLHQKGQETSTNSIASIFAWTRGLEHRAKLDNNEKLRDFTY 427
Query: 384 SLERATIKTIEGGHMTKDLALCVHGAAALQRSHYETTEVFIDSVAEELARSVK 436
LE A ++T+E G MTKDLAL +HG + R +Y TE FID+VA L R ++
Sbjct: 428 KLEAACVETVESGKMTKDLALLIHGP-KVSREYYLNTEEFIDAVAHNLKRKLQ 479
>ref|NP_001014183.1| isocitrate dehydrogenase 2 (NADP+), mitochondrial [Rattus
norvegicus]
sp|P56574|IDHP_RAT Isocitrate dehydrogenase [NADP], mitochondrial precursor
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) (IDP) (ICD-M)
gb|AAH76398.1| Similar to NADP+-specific isocitrate dehydrogenase [Rattus
norvegicus]
gb|EDM08608.1| similar to NADP+-specific isocitrate dehydrogenase, isoform CRA_b
[Rattus norvegicus]
Length = 452
Score = 701 bits (1809), Expect = 0.0, Method: Composition-based stats.
Identities = 264/441 (59%), Positives = 332/441 (75%), Gaps = 11/441 (2%)
Query: 5 VACAASSVNAGALTPRFVS--------TTRPSLGRIKVSGTVVDMDGDEMTRIIWALIKE 56
C AS P ++ + RIKV VV+MDGDEMTRIIW IKE
Sbjct: 10 SLCRASGSTRT-WAPAALNVPSWPEQPRRHYAEKRIKVEKPVVEMDGDEMTRIIWQFIKE 68
Query: 57 KLILPHVDVPIEYYDLSITSRDASNDKVTEQAAEAIQRHNVGIKCATITPDEARVKEFNL 116
KLILPHVDV ++Y+DL + +RD +ND+VT +A A Q+++V +KCATITPDEARV+EF L
Sbjct: 69 KLILPHVDVQLKYFDLGLPNRDQTNDQVTIDSALATQKYSVAVKCATITPDEARVEEFKL 128
Query: 117 KKMWKSPNGTIRNILGGTVFREPIIVKNVPRVVPQWSEPIIVGRHAYGDQYKATESLFP- 175
KKMWKSPNGTIRNILGGTVFREPII KN+PR+VP W++PI +GRHA+GDQYKAT+ +
Sbjct: 129 KKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYKATDFVVDR 188
Query: 176 PGRLELVHTPANGGSPQVLEVFNFKGEGVGLAMYNTRESVEAFAESCFEYAIMRRYPLVL 235
G +LV TP +G + EV+NF GVG+ MYNT ES+ FA SCF+Y+I +++PL L
Sbjct: 189 AGMFKLVFTPKDGSGAKEWEVYNFPAGGVGMGMYNTDESISGFAHSCFQYSIQKKWPLYL 248
Query: 236 STKNTILKKYDGLFLETFQRMYDTKYREQFERLNLTYVHRLIDDQVAQMIKGNGGFVWAC 295
STKNTI+K YDG F + FQ ++D Y+ F++ + Y HRLIDD VAQ++K +GGFVWAC
Sbjct: 249 STKNTIMKAYDGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKSSGGFVWAC 308
Query: 296 KNYDGDVQSDIVAQGFGSLGLMTSVLLCPDGKTIESEAAHGTVTRHYREHQKGKETSTNS 355
KNYDGDVQSDI+AQGFGSLGLMTSVL+CPDGKTIE+EAAHGTVTRHYREHQKG+ TSTN
Sbjct: 309 KNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNP 368
Query: 356 VASIFAWTRGLAHRGKLDGNAPLVEFASSLERATIKTIEGGHMTKDLALCVHGAAALQ-R 414
+ASIFAWTRGL HRGKLDGN L+ FA +LE+ ++T+E G MTKDLA C+HG + ++
Sbjct: 369 IASIFAWTRGLEHRGKLDGNQDLIRFAQTLEKVCVQTVESGAMTKDLAGCIHGLSNVKLN 428
Query: 415 SHYETTEVFIDSVAEELARSV 435
H+ T F+D++ L R++
Sbjct: 429 EHFLNTTDFLDTIKSNLDRAL 449
>sp|P33198|IDHP_PIG Isocitrate dehydrogenase [NADP], mitochondrial precursor
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) (IDP) (ICD-M)
gb|AAA31089.1| NADPH-specific isocitrate dehydrogenase
Length = 421
Score = 700 bits (1808), Expect = 0.0, Method: Composition-based stats.
Identities = 260/416 (62%), Positives = 329/416 (79%), Gaps = 2/416 (0%)
Query: 22 VSTTRPSLGRIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASN 81
+ + RIKV+ VV+MDGDEMTRIIW IKEKLILPHVDV ++Y+DL + +RD +N
Sbjct: 3 AAARHYADQRIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDVQLKYFDLGLPNRDQTN 62
Query: 82 DKVTEQAAEAIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPII 141
D+VT +A A Q+++V +KCATITPDEARV+EF LKKMWKSPNGTIRNILGGTVFREPII
Sbjct: 63 DQVTIDSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPII 122
Query: 142 VKNVPRVVPQWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNFK 200
KN+PR+VP W++PI +GRHA+GDQYKAT+ + G ++V TP +G S + EV+NF
Sbjct: 123 CKNIPRLVPGWTKPITIGRHAHGDQYKATDFVVDRAGTFKIVFTPKDGSSAKQWEVYNFP 182
Query: 201 GEGVGLAMYNTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTK 260
GVG+ MYNT ES+ FA SCF+YAI +++PL +STKNTILK YDG F + FQ +++
Sbjct: 183 AGGVGMGMYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFEKH 242
Query: 261 YREQFERLNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSV 320
Y+ F++ + Y HRLIDD VAQ++K +GGFVWACKNYDGDVQSDI+AQGFGSLGLMTSV
Sbjct: 243 YKTDFDKYKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSV 302
Query: 321 LLCPDGKTIESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVE 380
L+CPDGKTIE+EAAHGTVTRHYREHQKG+ TSTN +ASIFAWTRGL HRGKLDGN L+
Sbjct: 303 LVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIR 362
Query: 381 FASSLERATIKTIEGGHMTKDLALCVHGAAALQ-RSHYETTEVFIDSVAEELARSV 435
FA +LE+ ++T+E G MTKDLA C+HG + ++ H+ T F+D++ L R++
Sbjct: 363 FAQTLEKVCVETVESGAMTKDLAGCIHGLSNVKLNEHFLNTSDFLDTIKSNLDRAL 418
>pdb|1LWD|A Chain A, Crystal Structure Of Nadp-Dependent Isocitrate
Dehydrogenase From Porcine Heart Mitochondria
pdb|1LWD|B Chain B, Crystal Structure Of Nadp-Dependent Isocitrate
Dehydrogenase From Porcine Heart Mitochondria
Length = 413
Score = 700 bits (1808), Expect = 0.0, Method: Composition-based stats.
Identities = 260/410 (63%), Positives = 328/410 (80%), Gaps = 2/410 (0%)
Query: 28 SLGRIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQ 87
+ RIKV+ VV+MDGDEMTRIIW IKEKLILPHVDV ++Y+DL + +RD +ND+VT
Sbjct: 1 ADQRIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDVQLKYFDLGLPNRDQTNDQVTID 60
Query: 88 AAEAIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPR 147
+A A Q+++V +KCATITPDEARV+EF LKKMWKSPNGTIRNILGGTVFREPII KN+PR
Sbjct: 61 SALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPR 120
Query: 148 VVPQWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNFKGEGVGL 206
+VP W++PI +GRHA+GDQYKAT+ + G ++V TP +G S + EV+NF GVG+
Sbjct: 121 LVPGWTKPITIGRHAHGDQYKATDFVVDRAGTFKIVFTPKDGSSAKQWEVYNFPAGGVGM 180
Query: 207 AMYNTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFE 266
MYNT ES+ FA SCF+YAI +++PL +STKNTILK YDG F + FQ +++ Y+ F+
Sbjct: 181 GMYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFEKHYKTDFD 240
Query: 267 RLNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDG 326
+ + Y HRLIDD VAQ++K +GGFVWACKNYDGDVQSDI+AQGFGSLGLMTSVL+CPDG
Sbjct: 241 KYKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDG 300
Query: 327 KTIESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLE 386
KTIE+EAAHGTVTRHYREHQKG+ TSTN +ASIFAWTRGL HRGKLDGN L+ FA +LE
Sbjct: 301 KTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQTLE 360
Query: 387 RATIKTIEGGHMTKDLALCVHGAAALQ-RSHYETTEVFIDSVAEELARSV 435
+ ++T+E G MTKDLA C+HG + ++ H+ T F+D++ L R++
Sbjct: 361 KVCVETVESGAMTKDLAGCIHGLSNVKLNEHFLNTSDFLDTIKSNLDRAL 410
>dbj|BAD96636.1| isocitrate dehydrogenase 2 (NADP+), mitochondrial precursor variant
[Homo sapiens]
Length = 452
Score = 700 bits (1808), Expect = 0.0, Method: Composition-based stats.
Identities = 262/441 (59%), Positives = 330/441 (74%), Gaps = 9/441 (2%)
Query: 4 RVACAASSVNAGALTPRFVS-------TTRPSLGRIKVSGTVVDMDGDEMTRIIWALIKE 56
R C AS + + RIKV+ VV+MDGDEMTRIIW IKE
Sbjct: 9 RSLCRASGSRPAWAPAALTAPTSQEQPRRHYADKRIKVAKPVVEMDGDEMTRIIWQFIKE 68
Query: 57 KLILPHVDVPIEYYDLSITSRDASNDKVTEQAAEAIQRHNVGIKCATITPDEARVKEFNL 116
KLILPHVD+ ++Y+DL + +RD ++D+VT +A A Q+++V +KCATITPDEARV+EF L
Sbjct: 69 KLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDEARVEEFKL 128
Query: 117 KKMWKSPNGTIRNILGGTVFREPIIVKNVPRVVPQWSEPIIVGRHAYGDQYKATESLFP- 175
KKMWKSPNGTIRNILGGTVFREPII KN+PR+VP W++PI +GRHA+GDQYKAT+ +
Sbjct: 129 KKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYKATDFVADR 188
Query: 176 PGRLELVHTPANGGSPQVLEVFNFKGEGVGLAMYNTRESVEAFAESCFEYAIMRRYPLVL 235
G ++V TP +G + EV+NF GVG+ MYNT ES+ FA SCF+YAI +++PL +
Sbjct: 189 AGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMYNTDESISGFAHSCFQYAIQKKWPLYM 248
Query: 236 STKNTILKKYDGLFLETFQRMYDTKYREQFERLNLTYVHRLIDDQVAQMIKGNGGFVWAC 295
STKNTILK YDG F + FQ ++D Y F++ + Y HRLIDD VAQ++K +GGFVWAC
Sbjct: 249 STKNTILKAYDGRFKDIFQEIFDKHYETDFDKNKIWYEHRLIDDMVAQVLKSSGGFVWAC 308
Query: 296 KNYDGDVQSDIVAQGFGSLGLMTSVLLCPDGKTIESEAAHGTVTRHYREHQKGKETSTNS 355
KNYDGDVQSDI+AQGFGSLGLMTSVL+CPDGKTIE+EAAHGTVTRHYREHQKG+ TSTN
Sbjct: 309 KNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNP 368
Query: 356 VASIFAWTRGLAHRGKLDGNAPLVEFASSLERATIKTIEGGHMTKDLALCVHGAAALQ-R 414
+ASIFAWTRGL HRGKLDGN L+ FA LE+ ++T+E G MTKDLA C+HG + ++
Sbjct: 369 IASIFAWTRGLEHRGKLDGNQDLIRFAQMLEKVCVETVESGAMTKDLAGCIHGLSNVKLN 428
Query: 415 SHYETTEVFIDSVAEELARSV 435
H+ T F+D++ L R++
Sbjct: 429 EHFLNTTDFLDTIKSNLDRAL 449
>gb|ABF20244.1| mitochondrial isocitrate dehydrogenase [Leishmania infantum]
gb|ABF20245.1| mitochondrial isocitrate dehydrogenase [Leishmania infantum]
gb|ABF20246.1| mitochondrial isocitrate dehydrogenase [Leishmania infantum]
gb|ABF20247.1| mitochondrial isocitrate dehydrogenase [Leishmania infantum]
gb|ABF20248.1| mitochondrial isocitrate dehydrogenase [Leishmania infantum]
gb|ABF20249.1| mitochondrial isocitrate dehydrogenase [Leishmania infantum]
gb|ABF20250.1| mitochondrial isocitrate dehydrogenase [Leishmania infantum]
gb|ABF20251.1| mitochondrial isocitrate dehydrogenase [Leishmania infantum]
gb|ABF20252.1| mitochondrial isocitrate dehydrogenase [Leishmania donovani]
gb|ABF20253.1| mitochondrial isocitrate dehydrogenase [Leishmania donovani]
gb|ABF20254.1| mitochondrial isocitrate dehydrogenase [Leishmania donovani
archibaldi]
gb|ABF20255.1| mitochondrial isocitrate dehydrogenase [Leishmania donovani]
gb|ABF20256.1| mitochondrial isocitrate dehydrogenase [Leishmania donovani]
gb|ABF20257.1| mitochondrial isocitrate dehydrogenase [Leishmania infantum]
gb|ABF20258.1| mitochondrial isocitrate dehydrogenase [Leishmania infantum]
gb|ABF20259.1| mitochondrial isocitrate dehydrogenase [Leishmania donovani]
gb|ABF20260.1| mitochondrial isocitrate dehydrogenase [Leishmania donovani]
gb|ABF20261.1| mitochondrial isocitrate dehydrogenase [Leishmania infantum]
gb|ABF20262.1| mitochondrial isocitrate dehydrogenase [Leishmania infantum]
gb|ABF20263.1| mitochondrial isocitrate dehydrogenase [Leishmania infantum]
gb|ABF20264.1| mitochondrial isocitrate dehydrogenase [Leishmania infantum]
gb|ABF20265.1| mitochondrial isocitrate dehydrogenase [Leishmania infantum]
gb|ABF20266.1| mitochondrial isocitrate dehydrogenase [Leishmania infantum]
gb|ABF20267.1| mitochondrial isocitrate dehydrogenase [Leishmania donovani
archibaldi]
gb|ABF20268.1| mitochondrial isocitrate dehydrogenase [Leishmania donovani
archibaldi]
gb|ABF20269.1| mitochondrial isocitrate dehydrogenase [Leishmania donovani]
gb|ABF20270.1| mitochondrial isocitrate dehydrogenase [Leishmania infantum]
Length = 435
Score = 700 bits (1807), Expect = 0.0, Method: Composition-based stats.
Identities = 317/417 (76%), Positives = 372/417 (89%)
Query: 21 FVSTTRPSLGRIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDAS 80
F ST RIKV VVDMDGDEMTRIIW+ IKEKLILP+VDVPI Y+DLS+T+RDA+
Sbjct: 19 FSSTNVYLDKRIKVKNEVVDMDGDEMTRIIWSFIKEKLILPYVDVPINYFDLSVTNRDAT 78
Query: 81 NDKVTEQAAEAIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPI 140
NDKVT +AAEAI++ NVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPI
Sbjct: 79 NDKVTVEAAEAIKKCNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPI 138
Query: 141 IVKNVPRVVPQWSEPIIVGRHAYGDQYKATESLFPPGRLELVHTPANGGSPQVLEVFNFK 200
IV N+PR+VPQW PI+VGRHA+GDQYKAT+++ PG+L+LVHTPA+G +P L+V++FK
Sbjct: 139 IVSNIPRIVPQWHNPIVVGRHAFGDQYKATDAVLKPGKLQLVHTPADGSAPTTLDVYDFK 198
Query: 201 GEGVGLAMYNTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTK 260
GEGVGLAMYNT+ES+E FA+SCF+YA+MR+YPLVL+TKNTILKKYDG+FL+TFQRMYD +
Sbjct: 199 GEGVGLAMYNTKESIEGFAKSCFQYALMRKYPLVLTTKNTILKKYDGMFLQTFQRMYDEQ 258
Query: 261 YREQFERLNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSV 320
Y+ FE+ +TY HRLIDDQVAQMIKG GGFVWACKNYDGDVQSDIVAQGFGSLGLMTSV
Sbjct: 259 YKADFEKAGITYNHRLIDDQVAQMIKGEGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSV 318
Query: 321 LLCPDGKTIESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVE 380
L+CPDGKTIE+EAAHGTVTRHYR+HQ+GKETSTNSVASI+AWTRGLAHRGKLDGN+ LV+
Sbjct: 319 LMCPDGKTIEAEAAHGTVTRHYRQHQQGKETSTNSVASIYAWTRGLAHRGKLDGNSDLVK 378
Query: 381 FASSLERATIKTIEGGHMTKDLALCVHGAAALQRSHYETTEVFIDSVAEELARSVKG 437
F+ +LER +K IE GHMTKDLALCV+G++ ++R HYETTE F+DSV L +++
Sbjct: 379 FSETLERVVVKAIEDGHMTKDLALCVYGSSGVKREHYETTEQFLDSVDAALKKAMSA 435
>ref|XP_001463680.1| isocitrate dehydrogenase [NADP], mitochondrial precursor, putative
[Leishmania infantum JPCM5]
emb|CAM66047.1| isocitrate dehydrogenase [NADP], mitochondrial precursor, putative
[Leishmania infantum]
Length = 435
Score = 700 bits (1806), Expect = 0.0, Method: Composition-based stats.
Identities = 317/417 (76%), Positives = 372/417 (89%)
Query: 21 FVSTTRPSLGRIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDAS 80
F ST RIKV VVDMDGDEMTRIIW+ IKEKLILP+VDVPI Y+DLS+T+RDA+
Sbjct: 19 FSSTNVYLDKRIKVKNEVVDMDGDEMTRIIWSFIKEKLILPYVDVPINYFDLSVTNRDAT 78
Query: 81 NDKVTEQAAEAIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPI 140
NDKVT +AAEAI++ NVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPI
Sbjct: 79 NDKVTVEAAEAIKKCNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPI 138
Query: 141 IVKNVPRVVPQWSEPIIVGRHAYGDQYKATESLFPPGRLELVHTPANGGSPQVLEVFNFK 200
IV N+PR+VPQW PI+VGRHA+GDQYKAT+++ PG+L+LVHTPA+G +P L+V++FK
Sbjct: 139 IVSNIPRIVPQWHNPIVVGRHAFGDQYKATDAVLKPGKLQLVHTPADGSAPTTLDVYDFK 198
Query: 201 GEGVGLAMYNTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTK 260
GEGVGLAMYNT+ES+E FA+SCF+YA+MR+YPLVL+TKNTILKKYDG+FL+TFQRMYD +
Sbjct: 199 GEGVGLAMYNTKESIEGFAKSCFQYALMRKYPLVLTTKNTILKKYDGMFLQTFQRMYDEQ 258
Query: 261 YREQFERLNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSV 320
Y+ FE+ +TY HRLIDDQVAQMIKG GGFVWACKNYDGDVQSDIVAQGFGSLGLMTSV
Sbjct: 259 YKADFEKAGITYNHRLIDDQVAQMIKGEGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSV 318
Query: 321 LLCPDGKTIESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVE 380
L+CPDGKTIE+EAAHGTVTRHYR+HQ+GKETSTNSVASI+AWTRGLAHRGKLDGN+ LV+
Sbjct: 319 LMCPDGKTIEAEAAHGTVTRHYRQHQQGKETSTNSVASIYAWTRGLAHRGKLDGNSDLVK 378
Query: 381 FASSLERATIKTIEGGHMTKDLALCVHGAAALQRSHYETTEVFIDSVAEELARSVKG 437
F+ +LER +K IE GHMTKDLALCV+G++ ++R HYETTE F+DSV L +++
Sbjct: 379 FSETLERVVVKAIEDGHMTKDLALCVYGSSGVKREHYETTEQFLDSVDAALKKAMSA 435
>ref|NP_001080321.1| hypothetical protein LOC380013 [Xenopus laevis]
gb|AAH54241.1| MGC64442 protein [Xenopus laevis]
Length = 454
Score = 699 bits (1805), Expect = 0.0, Method: Composition-based stats.
Identities = 261/439 (59%), Positives = 331/439 (75%), Gaps = 7/439 (1%)
Query: 4 RVACAASSVNAGALTPRFVSTTR----PSLGRIKVSGTVVDMDGDEMTRIIWALIKEKLI 59
R + A N G L P + + RIKV+ VV+MDGDEMTRIIW IKEKLI
Sbjct: 13 RASATALGKNPGVLAPALSQQLQQQRNYADKRIKVANPVVEMDGDEMTRIIWEFIKEKLI 72
Query: 60 LPHVDVPIEYYDLSITSRDASNDKVTEQAAEAIQRHNVGIKCATITPDEARVKEFNLKKM 119
L +VDV ++Y+DL + RD ++D+VT +A A ++NV +KCATITPDEARV+EF LKKM
Sbjct: 73 LSNVDVELKYFDLGLPYRDQTDDQVTIDSALATLKYNVAVKCATITPDEARVEEFKLKKM 132
Query: 120 WKSPNGTIRNILGGTVFREPIIVKNVPRVVPQWSEPIIVGRHAYGDQYKATESLF-PPGR 178
WKSPNGT+RNILGGTVFREPII KN+PR+VP W++ I +GRHA+GDQYKAT+ + G
Sbjct: 133 WKSPNGTVRNILGGTVFREPIICKNIPRLVPGWTQAITIGRHAHGDQYKATDFVVDQAGT 192
Query: 179 LELVHTPANGGSPQVLEVFNFKGEGVGLAMYNTRESVEAFAESCFEYAIMRRYPLVLSTK 238
++V TPANG + + EVF F GVG+ MYNT ES+ FA SCF+YAI +++PL +STK
Sbjct: 193 FKMVFTPANGTATKEWEVFKFPAGGVGMGMYNTDESISGFAHSCFQYAIQKKWPLYMSTK 252
Query: 239 NTILKKYDGLFLETFQRMYDTKYREQFERLNLTYVHRLIDDQVAQMIKGNGGFVWACKNY 298
NTILK YDG F + FQ +++ Y+ F+++ + Y HRLIDD VAQ++K +GGFVWACKNY
Sbjct: 253 NTILKAYDGRFKDIFQDIFEKHYKPDFDKVKIWYEHRLIDDMVAQVLKSSGGFVWACKNY 312
Query: 299 DGDVQSDIVAQGFGSLGLMTSVLLCPDGKTIESEAAHGTVTRHYREHQKGKETSTNSVAS 358
DGDVQSDI+AQGFGSLGLM+SVL+CPDGKTIE+EAAHGTVTRHYREHQKG+ TSTN +AS
Sbjct: 313 DGDVQSDILAQGFGSLGLMSSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIAS 372
Query: 359 IFAWTRGLAHRGKLDGNAPLVEFASSLERATIKTIEGGHMTKDLALCVHGAAALQR--SH 416
IFAWTRGL HRGKLDGN L+ F+ LE+ ++T+E G MTKDLA C+HG + R H
Sbjct: 373 IFAWTRGLEHRGKLDGNQDLINFSLKLEKVCVETVESGIMTKDLAGCIHGGMSNVRLNEH 432
Query: 417 YETTEVFIDSVAEELARSV 435
Y T F+D++ L +++
Sbjct: 433 YVNTTDFLDAIKNNLDKAL 451
>ref|XP_421965.2| PREDICTED: similar to cytosolic NADP-dependent isocitrate
dehydrogenase [Gallus gallus]
Length = 415
Score = 699 bits (1805), Expect = 0.0, Method: Composition-based stats.
Identities = 255/410 (62%), Positives = 316/410 (77%), Gaps = 2/410 (0%)
Query: 29 LGRIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQA 88
+ + G+VV+M GDEMTR+IW LIKEKLI P+VD+ + YDL I RDA+NDKVT +A
Sbjct: 1 MSKKIHGGSVVEMQGDEMTRVIWELIKEKLIFPYVDLDLHSYDLGIEHRDATNDKVTVEA 60
Query: 89 AEAIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRV 148
AEAI++++VGIKCATITPDE RV+EF LK+MWKSPNGTIRNILGGTVFRE II KN+PR+
Sbjct: 61 AEAIKKYHVGIKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 149 VPQWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNFKG-EGVGL 206
V W +PI++GRHAYGDQY+AT+ + P PG++E+ +TP +GG P V NF+ GV +
Sbjct: 121 VSGWVKPIVIGRHAYGDQYRATDFVVPGPGKVEMTYTPGDGGKPVTYLVHNFESCGGVAM 180
Query: 207 AMYNTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFE 266
MYN +S++ FA S F+ A+ + +PL +STKNTILK+YDG F + FQ +YD +Y+ QFE
Sbjct: 181 GMYNLDQSIKDFAHSSFQMALSKGWPLYMSTKNTILKRYDGRFKDIFQEIYDREYKSQFE 240
Query: 267 RLNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDG 326
+ Y HRLIDD VAQ +K GGFVWACKNYDGDVQSD VAQG+GSLG+MTSVL+CPDG
Sbjct: 241 AKKIWYEHRLIDDMVAQALKSEGGFVWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDG 300
Query: 327 KTIESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLE 386
KT+E+EAAHGTVTRHYR HQKG+ETSTN +ASIFAWTRGLAHR KLD N L FA++LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMHQKGQETSTNPIASIFAWTRGLAHRAKLDNNTSLKTFATALE 360
Query: 387 RATIKTIEGGHMTKDLALCVHGAAALQRSHYETTEVFIDSVAEELARSVK 436
I+TIE G MTKDLA C+ G + RS Y T F+D +A L +
Sbjct: 361 EVCIETIESGFMTKDLAACIKGLPNVTRSDYLNTFEFMDKLAANLKGKLA 410
>gb|EAX02083.1| isocitrate dehydrogenase 2 (NADP+), mitochondrial, isoform CRA_b
[Homo sapiens]
Length = 422
Score = 699 bits (1804), Expect = 0.0, Method: Composition-based stats.
Identities = 261/418 (62%), Positives = 329/418 (78%), Gaps = 2/418 (0%)
Query: 20 RFVSTTRPSLGRIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDA 79
R VS + RIKV+ VV+MDGDEMTRIIW IKEKLILPHVD+ ++Y+DL + +RD
Sbjct: 2 RCVSLLLDADKRIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQ 61
Query: 80 SNDKVTEQAAEAIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREP 139
++D+VT +A A Q+++V +KCATITPDEARV+EF LKKMWKSPNGTIRNILGGTVFREP
Sbjct: 62 TDDQVTIDSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREP 121
Query: 140 IIVKNVPRVVPQWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFN 198
II KN+PR+VP W++PI +GRHA+GDQYKAT+ + G ++V TP +G + EV+N
Sbjct: 122 IICKNIPRLVPGWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYN 181
Query: 199 FKGEGVGLAMYNTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYD 258
F GVG+ MYNT ES+ FA SCF+YAI +++PL +STKNTILK YDG F + FQ ++D
Sbjct: 182 FPAGGVGMGMYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFD 241
Query: 259 TKYREQFERLNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMT 318
Y+ F++ + Y HRLIDD VAQ++K +GGFVWACKNYDGDVQSDI+AQGFGSLGLMT
Sbjct: 242 KHYKTDFDKNKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMT 301
Query: 319 SVLLCPDGKTIESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPL 378
SVL+CPDGKTIE+EAAHGTVTRHYREHQKG+ TSTN +ASIFAWTRGL HRGKLDGN L
Sbjct: 302 SVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDL 361
Query: 379 VEFASSLERATIKTIEGGHMTKDLALCVHGAAALQ-RSHYETTEVFIDSVAEELARSV 435
+ FA LE+ ++T+E G MTKDLA C+HG + ++ H+ T F+D++ L R++
Sbjct: 362 IRFAQMLEKVCVETVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRAL 419
>gb|ABU41004.1| isocitrate dehydrogenase 1 [Anser anser]
Length = 415
Score = 698 bits (1803), Expect = 0.0, Method: Composition-based stats.
Identities = 255/410 (62%), Positives = 317/410 (77%), Gaps = 2/410 (0%)
Query: 29 LGRIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQA 88
+ + G+VV+M GDEMTR+IW LIKEKLI P+VD+ + YDL I RDA+NDKVT +A
Sbjct: 1 MSKKIHGGSVVEMQGDEMTRVIWELIKEKLIFPYVDLDLHSYDLGIEHRDATNDKVTVEA 60
Query: 89 AEAIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRV 148
AEAI++++VGIKCATITPDE RV+EF LK+MWKSPNGTIRNILGGTVFRE II KN+PR+
Sbjct: 61 AEAIKKYHVGIKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 149 VPQWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNFKG-EGVGL 206
V W +PI++GRHAYGDQY+AT+ + P PG++E+ +TP +GG P V NF+ GV +
Sbjct: 121 VSGWVKPIVIGRHAYGDQYRATDFVVPGPGKVEMTYTPGDGGKPVTYLVHNFESCGGVAM 180
Query: 207 AMYNTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFE 266
M+N +S++ FA S F+ A+ + +PL +STKNTILK+YDG F + FQ +YD +Y+ QFE
Sbjct: 181 GMFNLDQSIKDFAHSSFQMALSKGWPLYMSTKNTILKRYDGRFKDIFQEIYDREYKSQFE 240
Query: 267 RLNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDG 326
+ Y HRLIDD VAQ +K GGFVWACKNYDGDVQSD VAQG+GSLG+MTSVL+CPDG
Sbjct: 241 AKKIWYEHRLIDDMVAQALKSEGGFVWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDG 300
Query: 327 KTIESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLE 386
KT+E+EAAHGTVTRHYR HQKG+ETSTN +ASIFAWTRGLAHR KLD N L FA++LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMHQKGQETSTNPIASIFAWTRGLAHRAKLDNNTSLKTFAAALE 360
Query: 387 RATIKTIEGGHMTKDLALCVHGAAALQRSHYETTEVFIDSVAEELARSVK 436
I+TIE G MTKDLA C+ G + RS Y T F+D +AE L +
Sbjct: 361 EVCIETIESGFMTKDLAACIKGLPNVTRSDYLNTFEFMDKLAENLKGKLA 410
>ref|XP_001778805.1| predicted protein [Physcomitrella patens subsp. patens]
gb|EDQ56391.1| predicted protein [Physcomitrella patens subsp. patens]
Length = 411
Score = 698 bits (1803), Expect = 0.0, Method: Composition-based stats.
Identities = 260/412 (63%), Positives = 330/412 (80%), Gaps = 4/412 (0%)
Query: 27 PSLGRIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTE 86
+ +I V+ +V+MDGDEMTRIIW +IK+KLI P +D+ ++Y+DL I RDA++D+VT
Sbjct: 1 MAFAKIHVANPIVEMDGDEMTRIIWKMIKDKLIFPFLDLDLKYFDLGIEHRDATDDRVTI 60
Query: 87 QAAEAIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVP 146
++AEA +++NV +KCATITPDEARVKE+NLK MW+SPNGTIRNIL GTVFREPI+ KN+P
Sbjct: 61 ESAEATKKYNVAVKCATITPDEARVKEYNLKSMWRSPNGTIRNILNGTVFREPILCKNIP 120
Query: 147 RVVPQWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNFKG-EGV 204
++VP W+ PI +GRHA+GDQYKAT+++F PG+L++V P NGG Q L V++F+G GV
Sbjct: 121 KLVPGWTSPICIGRHAFGDQYKATDAVFKGPGKLKMVFVPENGGETQDLTVYDFEGAGGV 180
Query: 205 GLAMYNTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTK-YRE 263
L MYNT ES+ +FAES A +++PL LSTKNTILKKYDG F + FQ +Y+ + ++
Sbjct: 181 ALTMYNTDESIRSFAESSMAMAYEKKWPLYLSTKNTILKKYDGRFKDIFQEVYEQEGWKA 240
Query: 264 QFERLNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLC 323
+F+ + Y HRLIDD VA +K GG+VWACKNYDGDVQSD++AQGFGSLGLMTSVL+C
Sbjct: 241 KFDAAGIWYEHRLIDDMVAYALKSEGGYVWACKNYDGDVQSDMLAQGFGSLGLMTSVLVC 300
Query: 324 PDGKTIESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFAS 383
PDGKTIE+EAAHGTVTRHYR HQKG ETSTNS+ASIFAWTRGL+HRGKLDGN LV+FA+
Sbjct: 301 PDGKTIEAEAAHGTVTRHYRVHQKGGETSTNSIASIFAWTRGLSHRGKLDGNEKLVDFAT 360
Query: 384 SLERATIKTIEGGHMTKDLALCVHGAAALQRSHYETTEVFIDSVAEELARSV 435
LE+A + T+E G MTKDLAL +HG + L R Y TE FID+VAEEL +
Sbjct: 361 KLEQACVGTVENGKMTKDLALLIHG-SKLSRDTYLNTEEFIDAVAEELKSKL 411
>ref|XP_001168316.1| PREDICTED: isocitrate dehydrogenase 2 (NADP+), mitochondrial
isoform 3 [Pan troglodytes]
Length = 415
Score = 698 bits (1802), Expect = 0.0, Method: Composition-based stats.
Identities = 258/407 (63%), Positives = 326/407 (80%), Gaps = 2/407 (0%)
Query: 31 RIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQAAE 90
RIKV+ VV+MDGDEMTRIIW IKEKLILPHVD+ ++Y+DL + +RD ++D+VT +A
Sbjct: 6 RIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSAL 65
Query: 91 AIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRVVP 150
A Q+++V +KCATITPDEARV+EF LKKMWKSPNGTIRNILGGTVFREPII KN+PR+VP
Sbjct: 66 ATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVP 125
Query: 151 QWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNFKGEGVGLAMY 209
W++PI +GRHA+GDQYKAT+ + G ++V TP +G + EV+NF GVG+ MY
Sbjct: 126 GWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMY 185
Query: 210 NTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFERLN 269
NT ES+ FA SCF+YAI +++PL +STKNTILK YDG F + FQ ++D Y+ F++
Sbjct: 186 NTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNK 245
Query: 270 LTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDGKTI 329
+ Y HRLIDD VAQ++K +GGFVWACKNYDGDVQSDI+AQGFGSLGLMTSVL+CPDGKTI
Sbjct: 246 IWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTI 305
Query: 330 ESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLERAT 389
E+EAAHGTVTRHYREHQKG+ TSTN +ASIFAWTRGL HRGKLDGN L+ FA +LE+
Sbjct: 306 EAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQTLEKVC 365
Query: 390 IKTIEGGHMTKDLALCVHGAAALQ-RSHYETTEVFIDSVAEELARSV 435
++T+E G MTKDLA C+HG + ++ H+ T F+D++ L R++
Sbjct: 366 VETVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRAL 412
>ref|XP_001681361.1| isocitrate dehydrogenase [NADP], mitochondrial precursor, putative
[Leishmania major]
emb|CAJ02471.1| isocitrate dehydrogenase [NADP], mitochondrial precursor, putative
[Leishmania major]
Length = 435
Score = 698 bits (1801), Expect = 0.0, Method: Composition-based stats.
Identities = 316/417 (75%), Positives = 372/417 (89%)
Query: 21 FVSTTRPSLGRIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDAS 80
F ST RIKV VVDMDGDEMTRIIW+ IKEKLILP+VDVPI Y+DLS+T+RDA+
Sbjct: 19 FSSTNVYLDKRIKVKNEVVDMDGDEMTRIIWSFIKEKLILPYVDVPINYFDLSVTNRDAT 78
Query: 81 NDKVTEQAAEAIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPI 140
NDKVT +AAEA+++ NVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPI
Sbjct: 79 NDKVTVEAAEAVKKCNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPI 138
Query: 141 IVKNVPRVVPQWSEPIIVGRHAYGDQYKATESLFPPGRLELVHTPANGGSPQVLEVFNFK 200
IV N+PR+VPQW PI+VGRHA+GDQYKAT+++ PG+L+LVHTPA+G +P L+V++FK
Sbjct: 139 IVSNIPRIVPQWHNPIVVGRHAFGDQYKATDAVLKPGKLQLVHTPADGSAPTTLDVYDFK 198
Query: 201 GEGVGLAMYNTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTK 260
GEGVGLAMYNT+ES+E FA+SCF+YA+MR+YPLVL+TKNTILKKYDG+FL+TFQRMYD +
Sbjct: 199 GEGVGLAMYNTKESIEGFAKSCFQYALMRKYPLVLTTKNTILKKYDGMFLQTFQRMYDEQ 258
Query: 261 YREQFERLNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSV 320
Y+ FE+ +TY HRLIDDQVAQMIKG GGFVWACKNYDGDVQSDIVAQGFGSLGLMTSV
Sbjct: 259 YKADFEKAGITYNHRLIDDQVAQMIKGEGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSV 318
Query: 321 LLCPDGKTIESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVE 380
L+CPDGKTIE+EAAHGTVTRHYR+HQ+GKETSTNSVASI+AWTRGLAHRGKLDGN+ LV+
Sbjct: 319 LMCPDGKTIEAEAAHGTVTRHYRQHQQGKETSTNSVASIYAWTRGLAHRGKLDGNSDLVK 378
Query: 381 FASSLERATIKTIEGGHMTKDLALCVHGAAALQRSHYETTEVFIDSVAEELARSVKG 437
F+ +LER +K IE GHMTKDLALCV+G++ ++R HYETTE F+DSV L +++
Sbjct: 379 FSETLERVVVKAIEDGHMTKDLALCVYGSSGVKREHYETTEQFLDSVDTALKKAMSA 435
>ref|XP_001107627.1| PREDICTED: isocitrate dehydrogenase 1 (NADP+), soluble isoform 1
[Macaca mulatta]
ref|XP_001107810.1| PREDICTED: isocitrate dehydrogenase 1 (NADP+), soluble isoform 2
[Macaca mulatta]
ref|XP_001107875.1| PREDICTED: isocitrate dehydrogenase 1 (NADP+), soluble isoform 3
[Macaca mulatta]
ref|XP_001107934.1| PREDICTED: isocitrate dehydrogenase 1 (NADP+), soluble isoform 4
[Macaca mulatta]
ref|XP_001107992.1| PREDICTED: isocitrate dehydrogenase 1 (NADP+), soluble isoform 5
[Macaca mulatta]
Length = 414
Score = 697 bits (1799), Expect = 0.0, Method: Composition-based stats.
Identities = 255/410 (62%), Positives = 319/410 (77%), Gaps = 2/410 (0%)
Query: 29 LGRIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQA 88
+ + G+VV++ GDEMTRIIW LIKEKLI P+V++ ++ YDL I +RDA+ND+VT+ A
Sbjct: 1 MSKKISGGSVVELQGDEMTRIIWELIKEKLIFPYVELDLQSYDLGIENRDATNDQVTKDA 60
Query: 89 AEAIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRV 148
AEAI+++NVG+KCATITPDE RV+EF LK+MWKSPNGTIRNILGGTVFRE II KN+PR+
Sbjct: 61 AEAIKKYNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 149 VPQWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNFK-GEGVGL 206
V W +PII+GRHAYGDQY+AT+ + P PG++E+ +TP++G V NF+ G GV +
Sbjct: 121 VSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAM 180
Query: 207 AMYNTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFE 266
MYN +S+E FA S F+ A+ + +PL LSTKNTILKKYDG F + FQ +YD +Y+ QFE
Sbjct: 181 GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE 240
Query: 267 RLNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDG 326
+ Y HRLIDD VAQ +K GGF+WACKNYDGDVQSD VAQG+GSLG+MTSVL+CPDG
Sbjct: 241 AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG 300
Query: 327 KTIESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLE 386
KT+E+EAAHGTVTRHYR +QKG+ETSTN +ASIFAWTRGLAHR KLD N L FA++LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALE 360
Query: 387 RATIKTIEGGHMTKDLALCVHGAAALQRSHYETTEVFIDSVAEELARSVK 436
I+TIE G MTKDLA C+ G +QRS Y T F+D + E L +
Sbjct: 361 EVCIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLA 410
>ref|NP_001088022.1| hypothetical protein LOC494713 [Xenopus laevis]
gb|AAH82651.1| LOC494713 protein [Xenopus laevis]
Length = 415
Score = 696 bits (1798), Expect = 0.0, Method: Composition-based stats.
Identities = 251/411 (61%), Positives = 316/411 (76%), Gaps = 2/411 (0%)
Query: 29 LGRIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQA 88
+ + G+VV+M GDEMTR+IW LIKEKLILP+V++ + YDL + +RDA++D+VT A
Sbjct: 1 MSKKINGGSVVEMQGDEMTRVIWDLIKEKLILPYVELDLHSYDLGMENRDATDDQVTVDA 60
Query: 89 AEAIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRV 148
AEAI+++NVGIKCATITPDE RV+EFNLK+MWKSPNGTIRNILGGTVFRE II KN+PR+
Sbjct: 61 AEAIKKYNVGIKCATITPDEKRVEEFNLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 149 VPQWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNFKG-EGVGL 206
V W +PII+GRHAYGDQY+AT+ + P PG++E+ TP +GG + NF+ GV L
Sbjct: 121 VSGWIKPIIIGRHAYGDQYRATDFVVPGPGKVEISFTPKDGGEAIKYVIHNFEDCGGVAL 180
Query: 207 AMYNTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFE 266
MYNT +S+ FA S F+ A+ + +PL +STKNTILK+YDG F + FQ +Y+ +Y+ QFE
Sbjct: 181 GMYNTDQSIRDFAHSSFQMALSKSWPLYMSTKNTILKRYDGRFKDIFQEIYEKEYKSQFE 240
Query: 267 RLNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDG 326
+ Y HRLIDD VAQ +K GGF+WACKNYDGDVQSD VAQG+GSLG+MTSVL+CPDG
Sbjct: 241 ENKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDG 300
Query: 327 KTIESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLE 386
KT+E+EAAHGTVTRHYR HQKG+ETSTN +ASIFAW+RGL HR KLD N L FA++LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMHQKGQETSTNPIASIFAWSRGLDHRAKLDNNQELKNFATALE 360
Query: 387 RATIKTIEGGHMTKDLALCVHGAAALQRSHYETTEVFIDSVAEELARSVKG 437
I+TIE G MTKDLA C+ G +QR Y +T F+D + E L +
Sbjct: 361 EVCIETIEAGFMTKDLAACIKGLPNVQRGDYLSTFEFMDKLGENLQLKLAA 411
>ref|NP_851355.2| isocitrate dehydrogenase 1 (NADP+), soluble [Bos taurus]
gb|AAI03369.1| Isocitrate dehydrogenase 1 (NADP+), soluble [Bos taurus]
Length = 414
Score = 696 bits (1798), Expect = 0.0, Method: Composition-based stats.
Identities = 257/409 (62%), Positives = 319/409 (77%), Gaps = 3/409 (0%)
Query: 30 GRIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQAA 89
+I+ G+VV+M GDEMTRIIW LIKEKLI P+V++ + YDL I +RDA+ND+VT+ AA
Sbjct: 3 QKIQ-GGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAA 61
Query: 90 EAIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRVV 149
EAI+++NVG+KCATITPDE RV+EF LK+MWKSPNGTIRNILGGTVFRE II KN+PR+V
Sbjct: 62 EAIKKYNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLV 121
Query: 150 PQWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNF-KGEGVGLA 207
W +PII+GRHAYGDQY+AT+ + P PG++E+ +TP++G V V NF + GV +
Sbjct: 122 SGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEISYTPSDGSPKTVYLVHNFTESGGVAMG 181
Query: 208 MYNTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFER 267
MYN +S+E FA S F+ A+ + +PL LSTKNTILKKYDG F + FQ +YD +Y+ +FE
Sbjct: 182 MYNQDKSIEDFAHSSFQMALSKNWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSEFEA 241
Query: 268 LNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDGK 327
N+ Y HRLIDD VAQ +K GGF+WACKNYDGDVQSD VAQG+GSLG+MTSVL+CPDGK
Sbjct: 242 QNIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGK 301
Query: 328 TIESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLER 387
T+E+EAAHGTVTRHYR +QKG+ETSTN +ASIFAWTRGLAHR KLD N L FA +LE
Sbjct: 302 TVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELSFFAKALEE 361
Query: 388 ATIKTIEGGHMTKDLALCVHGAAALQRSHYETTEVFIDSVAEELARSVK 436
I+TIE G MTKDLA C+ G +QRS Y T F+D + E L +
Sbjct: 362 VCIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLQLKLA 410
>ref|NP_001009276.1| cytosolic NADP-isocitrate dehydrogenase [Ovis aries]
sp|Q6XUZ5|IDHC_SHEEP Isocitrate dehydrogenase [NADP] cytoplasmic (Cytosolic
NADP-isocitrate dehydrogenase) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP)
gb|AAP41947.1| cytosolic NADP-isocitrate dehydrogenase [Ovis aries]
Length = 414
Score = 696 bits (1798), Expect = 0.0, Method: Composition-based stats.
Identities = 259/408 (63%), Positives = 320/408 (78%), Gaps = 3/408 (0%)
Query: 31 RIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQAAE 90
+I+ G+VV+M GDEMTRIIW LIKEKLI P+VD+ + YDLSI +RDA+ND+VT+ AAE
Sbjct: 4 KIQ-GGSVVEMQGDEMTRIIWELIKEKLIFPYVDLDLHSYDLSIENRDATNDQVTKDAAE 62
Query: 91 AIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRVVP 150
AI+++NVG+KCATITPDE RV+EF LK+MWKSPNGTIRNILGGTVFRE II KN+PR+V
Sbjct: 63 AIKKYNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVS 122
Query: 151 QWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNF-KGEGVGLAM 208
W +PII+GRHAYGDQY+AT+ + P PG++E+ +TP++G V V NF + GV + M
Sbjct: 123 GWVKPIIIGRHAYGDQYRATDFVVPGPGKVEICYTPSDGSPKTVYLVHNFTESGGVAMGM 182
Query: 209 YNTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFERL 268
+N +S+E FA S F+ A+ + +PL LSTKNTILKKYDG F + FQ +YD +Y+ QFE
Sbjct: 183 FNQDKSIEDFAHSSFQMALSKNWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQ 242
Query: 269 NLTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDGKT 328
N+ Y HRLIDD VAQ +K GGF+WACKNYDGDVQSD VAQG+GSLG+MTSVL+CPDGKT
Sbjct: 243 NIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKT 302
Query: 329 IESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLERA 388
+E+EAAHGTVTRHYR +QKG+ETSTN +ASIFAWTRGLAHR KLD N L FA +LE
Sbjct: 303 VEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELSFFAKALEEV 362
Query: 389 TIKTIEGGHMTKDLALCVHGAAALQRSHYETTEVFIDSVAEELARSVK 436
I+TIE G MTKDLA C+ G +QRS Y T F+D + E L +
Sbjct: 363 CIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLQLKLA 410
>sp|Q9Z2K9|IDHC_MICME Isocitrate dehydrogenase [NADP] cytoplasmic (Cytosolic
NADP-isocitrate dehydrogenase) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP)
gb|AAD02924.1| cytosolic NADP-dependent isocitrate dehydrogenase [Microtus
mexicanus]
Length = 414
Score = 696 bits (1798), Expect = 0.0, Method: Composition-based stats.
Identities = 255/410 (62%), Positives = 316/410 (77%), Gaps = 2/410 (0%)
Query: 29 LGRIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQA 88
+ + G+VV+M GDEMTRIIW LIKEKLILP+V++ + YDL I +RDA+ND+VT+ A
Sbjct: 1 MSKKIHGGSVVEMQGDEMTRIIWELIKEKLILPYVELDLHSYDLGIENRDATNDQVTKDA 60
Query: 89 AEAIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRV 148
AEAI+++NVG+KCATITPDE RV+EF LK+MWKSPNGTIRNILGGTVFRE II KN+PR+
Sbjct: 61 AEAIKKYNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 149 VPQWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNFK-GEGVGL 206
V W +PII+GRHAYGDQY+AT+ + P PG++E+ TP +G V +F+ G GV +
Sbjct: 121 VTGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITFTPKDGSQKVTYLVHSFEEGGGVAM 180
Query: 207 AMYNTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFE 266
MYN +S+E FA S F+ A+ + +PL LSTKNTILKKYDG F + FQ +YD +Y+ QFE
Sbjct: 181 GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE 240
Query: 267 RLNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDG 326
+ Y HRLIDD VAQ +K GGF+WACKNYDGDVQSD VAQG+GSLG+MTSVL+CPDG
Sbjct: 241 AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDG 300
Query: 327 KTIESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLE 386
KT+E+EAAHGTVTRHYR HQKG+ETSTN +ASIFAW+RGLAHR +LD N L FA +LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMHQKGQETSTNPIASIFAWSRGLAHRARLDNNTELSFFAKALE 360
Query: 387 RATIKTIEGGHMTKDLALCVHGAAALQRSHYETTEVFIDSVAEELARSVK 436
I+TIE G MTKDLA C+ G +QRS Y T F+D + E L +
Sbjct: 361 EVCIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKAKLA 410
>ref|XP_850187.1| PREDICTED: similar to Isocitrate dehydrogenase [NADP] cytoplasmic
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) (IDP) isoform 2 [Canis familiaris]
ref|XP_536047.2| PREDICTED: similar to Isocitrate dehydrogenase [NADP] cytoplasmic
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) (IDP) isoform 1 [Canis familiaris]
Length = 414
Score = 696 bits (1797), Expect = 0.0, Method: Composition-based stats.
Identities = 257/409 (62%), Positives = 319/409 (77%), Gaps = 3/409 (0%)
Query: 30 GRIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQAA 89
+I+ G+VV+M GDEMTRIIW LIKEKLI P+V++ + YDL I +RDA+ND+VT+ AA
Sbjct: 3 QKIR-GGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAA 61
Query: 90 EAIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRVV 149
EAI+++NVG+KCATITPDE RV+EF LK+MWKSPNGTIRNILGGTVFRE II KN+PR+V
Sbjct: 62 EAIKKYNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLV 121
Query: 150 PQWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNFK-GEGVGLA 207
W +PII+GRHAYGDQY+AT+ + P PG++E+ +TP++G V NF+ G GV +
Sbjct: 122 SGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGSEKMTYLVHNFEEGGGVAMG 181
Query: 208 MYNTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFER 267
MYN +S+E FA S F+ A+ + +PL LSTKNTILKKYDG F + FQ +YD +Y+ QFE
Sbjct: 182 MYNQDKSIEDFAHSSFQMALSKSWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEA 241
Query: 268 LNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDGK 327
N+ Y HRLIDD VAQ +K GGF+WACKNYDGDVQSD VAQG+GSLG+MTSVL+CPDGK
Sbjct: 242 QNIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGK 301
Query: 328 TIESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLER 387
T+E+EAAHGTVTRHYR +QKG+ETSTN +ASIFAWTRGLAHR KLD N L FA +LE
Sbjct: 302 TVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELSFFAKALEE 361
Query: 388 ATIKTIEGGHMTKDLALCVHGAAALQRSHYETTEVFIDSVAEELARSVK 436
++TIE G MTKDLA C+ G +QRS Y T F+D + E L +
Sbjct: 362 VCVETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLNIKLA 410
>ref|ZP_01885694.1| isocitrate dehydrogenase [Pedobacter sp. BAL39]
gb|EDM34991.1| isocitrate dehydrogenase [Pedobacter sp. BAL39]
Length = 411
Score = 696 bits (1797), Expect = 0.0, Method: Composition-based stats.
Identities = 256/410 (62%), Positives = 319/410 (77%), Gaps = 1/410 (0%)
Query: 27 PSLGRIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTE 86
S+ +IKV VV++DGDEMTRIIW IK+KLILP++D+ I+YYDL + RD +ND+VT
Sbjct: 1 MSVQKIKVDQPVVELDGDEMTRIIWKFIKDKLILPYLDLDIKYYDLGVEYRDETNDQVTI 60
Query: 87 QAAEAIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVP 146
AAEAI+++ VGIKCATITPDE RVKEFNLK+MWKSPNGTIRNIL GTVFREPI++ NVP
Sbjct: 61 DAAEAIKQYGVGIKCATITPDEERVKEFNLKQMWKSPNGTIRNILDGTVFREPIVMSNVP 120
Query: 147 RVVPQWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNFKGEGVG 205
R+VP W+ PI +GRHA+GDQY+AT+ + G+L L TP +GG Q +V+NFKG+GV
Sbjct: 121 RLVPNWTAPICIGRHAFGDQYRATDLVTKGKGKLTLTFTPEDGGEVQSFDVYNFKGDGVA 180
Query: 206 LAMYNTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQF 265
LAMYNT ES+ FA +CF A+++++PL LSTKNTILKKYDG F + FQ +Y+ ++ +F
Sbjct: 181 LAMYNTDESIRGFANACFNQALIKKWPLYLSTKNTILKKYDGRFKDIFQEIYENDFKAKF 240
Query: 266 ERLNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPD 325
+ +TY HRLIDD VA +K NG FVWACKNYDGDVQSD VAQGFGSLGLMTSVL+ PD
Sbjct: 241 DEAGITYEHRLIDDMVASALKWNGNFVWACKNYDGDVQSDTVAQGFGSLGLMTSVLVTPD 300
Query: 326 GKTIESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSL 385
GKT+E+EAAHGTVTRHYR+HQ GK TSTN +ASIFAWTRGL RG LD N L++F +L
Sbjct: 301 GKTMEAEAAHGTVTRHYRDHQAGKPTSTNPIASIFAWTRGLEFRGVLDNNQELIKFCQAL 360
Query: 386 ERATIKTIEGGHMTKDLALCVHGAAALQRSHYETTEVFIDSVAEELARSV 435
E+ I+T+E G MTKDLA+C+HG HY TE F+ ++ E L +
Sbjct: 361 EQVCIETVESGKMTKDLAVCIHGNKVEHGKHYLYTEEFLAAIDENLQAKL 410
>emb|CAA53300.1| isocitrate dehydrogenase (NADP+) [Solanum tuberosum]
Length = 438
Score = 696 bits (1796), Expect = 0.0, Method: Composition-based stats.
Identities = 254/417 (60%), Positives = 317/417 (76%), Gaps = 2/417 (0%)
Query: 21 FVSTTRPSLGRIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDAS 80
F+S + + +I V +V+MDGDEMTR+IW IK+KLILP +++ I+Y+ L + RDA+
Sbjct: 17 FLSICKMAFQKITVQNPIVEMDGDEMTRVIWKSIKDKLILPFLELDIKYFSLGLPHRDAT 76
Query: 81 NDKVTEQAAEAIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPI 140
+DKVT ++AEA Q++NV IKCATITPDEARVKEFNLK MW+SPNGTIRNIL GTVFREPI
Sbjct: 77 DDKVTVESAEATQKYNVAIKCATITPDEARVKEFNLKSMWRSPNGTIRNILNGTVFREPI 136
Query: 141 IVKNVPRVVPQWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNF 199
+ KN+PR+VP W++PI +GRHA+GDQY+AT+++ G+L+LV P EV+NF
Sbjct: 137 MCKNIPRLVPGWTKPICIGRHAFGDQYRATDTVIKGAGKLKLVFVPEGSDEKTEFEVYNF 196
Query: 200 KG-EGVGLAMYNTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYD 258
G GV L+MYNT ESV +FAE+ A +++PL LSTKNTILKKYDG F + FQ +Y+
Sbjct: 197 TGAGGVALSMYNTDESVRSFAEASMNMAFQKKWPLYLSTKNTILKKYDGRFKDIFQEVYE 256
Query: 259 TKYREQFERLNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMT 318
++ ++E + Y HRLIDD VA +K GG+VWACKNYDGDVQSD +AQGFGSLGLMT
Sbjct: 257 ANWKSKYEEAGIWYEHRLIDDMVAYALKSEGGYVWACKNYDGDVQSDFLAQGFGSLGLMT 316
Query: 319 SVLLCPDGKTIESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPL 378
SVL+CPDGKTIE+EAAHGTVTRHYR HQKG ETSTNS+ASIFAWTRGLAHR LD N L
Sbjct: 317 SVLVCPDGKTIEAEAAHGTVTRHYRVHQKGGETSTNSIASIFAWTRGLAHRATLDNNERL 376
Query: 379 VEFASSLERATIKTIEGGHMTKDLALCVHGAAALQRSHYETTEVFIDSVAEELARSV 435
++F LE A I +E G MTKDLAL + + L R HY TE FID+VA+EL +
Sbjct: 377 LDFTEKLEAACIGAVESGKMTKDLALIIIHGSKLSREHYLNTEEFIDAVADELKARL 433
>ref|NP_113698.1| isocitrate dehydrogenase 1 (NADP+), soluble [Rattus norvegicus]
sp|P41562|IDHC_RAT Isocitrate dehydrogenase [NADP] cytoplasmic (Cytosolic
NADP-isocitrate dehydrogenase) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP)
gb|AAA59356.1| cytosolic NADP-dependent isocitrate dehydrogenase
gb|EDL98861.1| isocitrate dehydrogenase 1 (NADP+), soluble, isoform CRA_a [Rattus
norvegicus]
gb|EDL98863.1| isocitrate dehydrogenase 1 (NADP+), soluble, isoform CRA_a [Rattus
norvegicus]
gb|EDL98864.1| isocitrate dehydrogenase 1 (NADP+), soluble, isoform CRA_a [Rattus
norvegicus]
gb|EDL98865.1| isocitrate dehydrogenase 1 (NADP+), soluble, isoform CRA_a [Rattus
norvegicus]
Length = 414
Score = 696 bits (1796), Expect = 0.0, Method: Composition-based stats.
Identities = 255/410 (62%), Positives = 318/410 (77%), Gaps = 2/410 (0%)
Query: 29 LGRIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQA 88
+ R G+VV+M GDEMTRIIW LIKEKLILP+V++ + YDL I +RDA+ND+VT+ A
Sbjct: 1 MSRKIHGGSVVEMQGDEMTRIIWELIKEKLILPYVELDLHSYDLGIENRDATNDQVTKDA 60
Query: 89 AEAIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRV 148
AEAI+++NVG+KCATITPDE RV+EF LK+MWKSPNGTIRNILGGTVFRE II KN+PR+
Sbjct: 61 AEAIKKYNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 149 VPQWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNFK-GEGVGL 206
V W +PII+GRHAYGDQY+AT+ + P PG++E+ +TP +G V +F+ G GV +
Sbjct: 121 VTGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPKDGSQKVTYLVHDFEEGGGVAM 180
Query: 207 AMYNTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFE 266
MYN +S+E FA S F+ A+ + +PL LSTKNTILKKYDG F + FQ +YD +Y+ +FE
Sbjct: 181 GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSKFE 240
Query: 267 RLNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDG 326
+ Y HRLIDD VAQ +K GGF+WACKNYDGDVQSD VAQG+GSLG+MTSVL+CPDG
Sbjct: 241 AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDG 300
Query: 327 KTIESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLE 386
KT+E+EAAHGTVTRHYR +QKG+ETSTN +ASIFAW+RGLAHR KLD N L FA++LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWSRGLAHRAKLDNNTELSFFANALE 360
Query: 387 RATIKTIEGGHMTKDLALCVHGAAALQRSHYETTEVFIDSVAEELARSVK 436
I+TIE G MTKDLA C+ G +QRS Y T F+D + E L +
Sbjct: 361 EVCIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKAKLA 410
>sp|Q9Z2K8|IDHC_MICOH Isocitrate dehydrogenase [NADP] cytoplasmic (Cytosolic
NADP-isocitrate dehydrogenase) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP)
gb|AAD02925.1| cytosolic NADP-dependent isocitrate dehydrogenase [Microtus
ochrogaster]
Length = 414
Score = 696 bits (1796), Expect = 0.0, Method: Composition-based stats.
Identities = 255/410 (62%), Positives = 317/410 (77%), Gaps = 2/410 (0%)
Query: 29 LGRIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQA 88
+ + G+VV+M GDEMTRIIW LIKEKLILP+V++ + YDL I +RDA+ND+VT+ A
Sbjct: 1 MSKKIHGGSVVEMQGDEMTRIIWELIKEKLILPYVELDLHSYDLGIENRDATNDQVTKDA 60
Query: 89 AEAIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRV 148
AEAI+++NVG+KCATITPDE RV+EF LK+MWKSPNGTIRNILGGTVFRE II KN+PR+
Sbjct: 61 AEAIKKYNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 149 VPQWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNFK-GEGVGL 206
V W +PII+GRHAYGDQY+AT+ + P PG++E+ +TP +G V +F+ G GV +
Sbjct: 121 VTGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPKDGSQKVTYLVHSFEEGGGVAM 180
Query: 207 AMYNTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFE 266
MYN +S+E FA S F+ A+ + +PL LSTKNTILKKYDG F + FQ +YD +Y+ QFE
Sbjct: 181 GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE 240
Query: 267 RLNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDG 326
+ Y HRLIDD VAQ +K GGF+WACKNYDGDVQSD VAQG+GSLG+MTSVL+CPDG
Sbjct: 241 AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDG 300
Query: 327 KTIESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLE 386
KT+E+EAAHGTVTRHYR HQKG+ETSTN +ASIFAW+RGLAHR +LD N L FA +LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMHQKGQETSTNPIASIFAWSRGLAHRARLDNNTELSFFAKALE 360
Query: 387 RATIKTIEGGHMTKDLALCVHGAAALQRSHYETTEVFIDSVAEELARSVK 436
I+TIE G MTKDLA C+ G +QRS Y T F+D + E L +
Sbjct: 361 EVCIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKAKLA 410
>gb|ABF20271.1| mitochondrial isocitrate dehydrogenase [Leishmania gerbilli]
Length = 435
Score = 695 bits (1795), Expect = 0.0, Method: Composition-based stats.
Identities = 315/417 (75%), Positives = 370/417 (88%)
Query: 21 FVSTTRPSLGRIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDAS 80
F ST RIKV VVDMDGDEMTRIIW+ IKEKLILP+VDVPI Y+DLS+T+RDA+
Sbjct: 19 FSSTNVYLDKRIKVKNEVVDMDGDEMTRIIWSSIKEKLILPYVDVPINYFDLSVTNRDAT 78
Query: 81 NDKVTEQAAEAIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPI 140
NDKVT +AAEAI++ NVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPI
Sbjct: 79 NDKVTVEAAEAIKKCNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPI 138
Query: 141 IVKNVPRVVPQWSEPIIVGRHAYGDQYKATESLFPPGRLELVHTPANGGSPQVLEVFNFK 200
IV N+PR+VPQW PI+VGRHA+GDQYKAT+++ PG+L+LVHTPA+G +P L+V++FK
Sbjct: 139 IVSNIPRIVPQWHNPIVVGRHAFGDQYKATDAVLKPGKLQLVHTPADGSAPTTLDVYDFK 198
Query: 201 GEGVGLAMYNTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTK 260
GEGVGLAMYNT+ES+E FA+SCF+YA+MR+YPLVL+TKNTILKKYDG+FL+TFQRMYD +
Sbjct: 199 GEGVGLAMYNTKESIEGFAKSCFQYALMRKYPLVLTTKNTILKKYDGMFLQTFQRMYDEQ 258
Query: 261 YREQFERLNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSV 320
Y+ FE+ +TY HRLIDDQVAQMIKG GGFVWACKNY GD QSDIVAQGFGSLGLMTSV
Sbjct: 259 YKADFEKAGITYNHRLIDDQVAQMIKGEGGFVWACKNYGGDAQSDIVAQGFGSLGLMTSV 318
Query: 321 LLCPDGKTIESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVE 380
L+CPDGKTIE+EAAHGTVTRHYR+HQ+GKETSTNSVASI+AWTRGLAHRGKLDGN+ LV+
Sbjct: 319 LMCPDGKTIEAEAAHGTVTRHYRQHQQGKETSTNSVASIYAWTRGLAHRGKLDGNSDLVK 378
Query: 381 FASSLERATIKTIEGGHMTKDLALCVHGAAALQRSHYETTEVFIDSVAEELARSVKG 437
F+ +LER +K IE GHMTKDLALCV+G++ ++R HYETTE F+DSV L +++
Sbjct: 379 FSETLERVVVKAIEDGHMTKDLALCVYGSSGVKREHYETTEQFLDSVDAALKKAMSA 435
>ref|XP_001562802.1| isocitrate dehydrogenase [NADP], mitochondrial precursor, putative
[Leishmania braziliensis MHOM/BR/75/M2904]
emb|CAM37233.1| isocitrate dehydrogenase [NADP], mitochondrial precursor, putative
[Leishmania braziliensis]
Length = 435
Score = 695 bits (1794), Expect = 0.0, Method: Composition-based stats.
Identities = 317/436 (72%), Positives = 379/436 (86%), Gaps = 4/436 (0%)
Query: 1 MFRRVACAASSVNAGALTPRFVSTTRPSLGR-IKVSGTVVDMDGDEMTRIIWALIKEKLI 59
MFRRV+ A++S R S+T LG+ IKV VVDMDGDEMTRIIW+LIKEKLI
Sbjct: 1 MFRRVSAASASSLV---AVRAFSSTNVCLGKRIKVKNEVVDMDGDEMTRIIWSLIKEKLI 57
Query: 60 LPHVDVPIEYYDLSITSRDASNDKVTEQAAEAIQRHNVGIKCATITPDEARVKEFNLKKM 119
LP+VDVPI Y+DLS+T RDA+NDKVT AAEAI + NVGIKCATITPDE+RV EFNLKKM
Sbjct: 58 LPYVDVPINYFDLSVTHRDATNDKVTVDAAEAIMKCNVGIKCATITPDESRVTEFNLKKM 117
Query: 120 WKSPNGTIRNILGGTVFREPIIVKNVPRVVPQWSEPIIVGRHAYGDQYKATESLFPPGRL 179
WKSPNGTIRNILGGTVFREPIIV N+PR+V W EPI+VGRHA+GDQYKAT++++ PG+L
Sbjct: 118 WKSPNGTIRNILGGTVFREPIIVSNIPRIVKHWKEPIVVGRHAFGDQYKATDTIYKPGKL 177
Query: 180 ELVHTPANGGSPQVLEVFNFKGEGVGLAMYNTRESVEAFAESCFEYAIMRRYPLVLSTKN 239
+LVHTPA+G +P L+V++FK EGVG+AMYNT++S+E FA+SCF+YA+MR+YPLVL+TKN
Sbjct: 178 QLVHTPADGSAPTTLDVYDFKSEGVGMAMYNTKKSIEGFAKSCFQYALMRKYPLVLTTKN 237
Query: 240 TILKKYDGLFLETFQRMYDTKYREQFERLNLTYVHRLIDDQVAQMIKGNGGFVWACKNYD 299
TILKKYDG+FL+TFQRMY+ +Y+ FE+ +TY HRLIDDQVAQMIKG GGFVWACKNYD
Sbjct: 238 TILKKYDGVFLQTFQRMYEEQYKSDFEKAGITYNHRLIDDQVAQMIKGEGGFVWACKNYD 297
Query: 300 GDVQSDIVAQGFGSLGLMTSVLLCPDGKTIESEAAHGTVTRHYREHQKGKETSTNSVASI 359
GDVQSDIVAQGFGSLGLMTSVL+CPDGKTIE+EAAHGTVTRHYR+HQ+GKETSTNS+ASI
Sbjct: 298 GDVQSDIVAQGFGSLGLMTSVLMCPDGKTIEAEAAHGTVTRHYRQHQQGKETSTNSIASI 357
Query: 360 FAWTRGLAHRGKLDGNAPLVEFASSLERATIKTIEGGHMTKDLALCVHGAAALQRSHYET 419
+AWTRGLAHRGKLDGN LV+F+ LE+ IKT+E GHMTKDLALCVHG++ ++R YET
Sbjct: 358 YAWTRGLAHRGKLDGNCDLVKFSDMLEKVVIKTVEDGHMTKDLALCVHGSSGVKREQYET 417
Query: 420 TEVFIDSVAEELARSV 435
TE F++SV L +++
Sbjct: 418 TEEFLNSVDAALKKAM 433
>sp|Q9XSG3|IDHC_BOVIN Isocitrate dehydrogenase [NADP] cytoplasmic (Cytosolic
NADP-isocitrate dehydrogenase) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP)
gb|AAD34457.1|AF136009_1 cytosolic NADP+-dependent isocitrate dehydrogenase [Bos taurus]
Length = 414
Score = 694 bits (1792), Expect = 0.0, Method: Composition-based stats.
Identities = 256/409 (62%), Positives = 318/409 (77%), Gaps = 3/409 (0%)
Query: 30 GRIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQAA 89
+I+ G+VV+M GDEMTRIIW LIKEKLI P+V++ + YDL I +RDA+ND+VT+ AA
Sbjct: 3 QKIQ-GGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAA 61
Query: 90 EAIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRVV 149
EAI+++NVG+KCATITPDE RV+EF LK+MWKSPNGTIRNILGGTVFRE II KN+PR+V
Sbjct: 62 EAIKKYNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLV 121
Query: 150 PQWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNF-KGEGVGLA 207
W +PII+GRHAYGDQY+AT+ + P PG++E+ +TP++G V V NF + GV +
Sbjct: 122 SGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEISYTPSDGSPKTVYLVHNFTESGGVAMG 181
Query: 208 MYNTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFER 267
MYN +S+E FA S F+ A+ + +PL LSTKNTILKKYDG F + FQ +YD +Y+ +FE
Sbjct: 182 MYNQDKSIEDFAHSSFQMALSKNWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSEFEA 241
Query: 268 LNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDGK 327
N+ Y HRLIDD VAQ +K GGF+WACKNYDGDVQSD VAQG+GSLG+MTSVL+CPDGK
Sbjct: 242 QNIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGK 301
Query: 328 TIESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLER 387
T+E+EAAHGTVTRHYR +QKG+ET TN +ASIFAWTRGLAHR KLD N L FA +LE
Sbjct: 302 TVEAEAAHGTVTRHYRMYQKGQETLTNPIASIFAWTRGLAHRAKLDNNKELSFFAKALEE 361
Query: 388 ATIKTIEGGHMTKDLALCVHGAAALQRSHYETTEVFIDSVAEELARSVK 436
I+TIE G MTKDLA C+ G +QRS Y T F+D + E L +
Sbjct: 362 VCIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLQLKLA 410
>dbj|BAC39792.1| unnamed protein product [Mus musculus]
Length = 422
Score = 694 bits (1792), Expect = 0.0, Method: Composition-based stats.
Identities = 257/410 (62%), Positives = 317/410 (77%), Gaps = 2/410 (0%)
Query: 29 LGRIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQA 88
+ R G+VV+M GDEMTRIIW LIKEKLILP+V++ + YDL I +RDA+ND+VT+ A
Sbjct: 1 MSRKIQGGSVVEMQGDEMTRIIWELIKEKLILPYVELDLHSYDLGIENRDATNDQVTKDA 60
Query: 89 AEAIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRV 148
AEAI+++NVG+KCATITPDE RV+EF LK+MWKSPNGTIRNILGGTVFRE II KN+PR+
Sbjct: 61 AEAIKKYNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 149 VPQWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNFK-GEGVGL 206
V W +PII+GRHAYGDQY+AT+ + P PG++E+ +TP +G V +F+ G GV +
Sbjct: 121 VTGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPKDGTQKVTYMVHDFEEGGGVAM 180
Query: 207 AMYNTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFE 266
MYN +S+E FA S F+ A+ + +PL LSTKNTILKKYDG F + FQ +YD KY+ QFE
Sbjct: 181 GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKKYKSQFE 240
Query: 267 RLNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDG 326
+ Y HRLIDD VAQ +K GGF+WACKNYDGDVQSD VAQG+GSLG+MTSVL+CPDG
Sbjct: 241 AQKICYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDG 300
Query: 327 KTIESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLE 386
KT+E+EAAHGTVTRHYR +QKG+ETSTN +ASIFAW+RGLAHR KLD N L FA +LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWSRGLAHRAKLDNNTELSFFAKALE 360
Query: 387 RATIKTIEGGHMTKDLALCVHGAAALQRSHYETTEVFIDSVAEELARSVK 436
I+TIE G MTKDLA C+ G +QRS Y T F+D + E L +
Sbjct: 361 DVCIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKAKLA 410
>ref|XP_001168291.1| PREDICTED: isocitrate dehydrogenase 2 (NADP+), mitochondrial
isoform 2 [Pan troglodytes]
Length = 475
Score = 694 bits (1792), Expect = 0.0, Method: Composition-based stats.
Identities = 262/464 (56%), Positives = 332/464 (71%), Gaps = 32/464 (6%)
Query: 4 RVACAASSVNAGALTPRFVS-------TTRPSLGRIKVSGTVVDMDGDEMTRIIWALIKE 56
R C AS + + RIKV+ VV+MDGDEMTRIIW IKE
Sbjct: 9 RSLCRASGSRPAWAPAALTAPTSQEQPRRHYADKRIKVAKPVVEMDGDEMTRIIWQFIKE 68
Query: 57 KLILPHVDVPIEYYDLSITSRDASNDKVTEQAAEAIQRHNVGIKCATITPDEARVK---- 112
KLILPHVD+ ++Y+DL + +RD ++D+VT +A A Q+++V +KCATITPDEARV+
Sbjct: 69 KLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDEARVEVGGS 128
Query: 113 -------------------EFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRVVPQWS 153
EF LKKMWKSPNGTIRNILGGTVFREPII KN+PR+VP W+
Sbjct: 129 WRTVLEIHLQTPQACPCPAEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWT 188
Query: 154 EPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNFKGEGVGLAMYNTR 212
+PI +GRHA+GDQYKAT+ + G ++V TP +G + EV+NF GVG+ MYNT
Sbjct: 189 KPITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMYNTD 248
Query: 213 ESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFERLNLTY 272
ES+ FA SCF+YAI +++PL +STKNTILK YDG F + FQ ++D Y+ F++ + Y
Sbjct: 249 ESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNKIWY 308
Query: 273 VHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDGKTIESE 332
HRLIDD VAQ++K +GGFVWACKNYDGDVQSDI+AQGFGSLGLMTSVL+CPDGKTIE+E
Sbjct: 309 EHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAE 368
Query: 333 AAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLERATIKT 392
AAHGTVTRHYREHQKG+ TSTN +ASIFAWTRGL HRGKLDGN L+ FA +LE+ ++T
Sbjct: 369 AAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQTLEKVCVET 428
Query: 393 IEGGHMTKDLALCVHGAAALQ-RSHYETTEVFIDSVAEELARSV 435
+E G MTKDLA C+HG + ++ H+ T F+D++ L R++
Sbjct: 429 VESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRAL 472
>ref|XP_001698704.1| isocitrate dehydrogenase, NADP-dependent [Chlamydomonas
reinhardtii]
gb|EDO99386.1| isocitrate dehydrogenase, NADP-dependent [Chlamydomonas
reinhardtii]
Length = 483
Score = 693 bits (1790), Expect = 0.0, Method: Composition-based stats.
Identities = 275/415 (66%), Positives = 338/415 (81%), Gaps = 1/415 (0%)
Query: 24 TTRPSLGRIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDK 83
T + G+I V+ VVD+DGDEMTR+IW IK+KLILP++D+ I Y+DL + +RD +NDK
Sbjct: 67 RTMATAGKIHVANPVVDLDGDEMTRVIWQQIKDKLILPYLDLKIVYFDLGLPNRDKTNDK 126
Query: 84 VTEQAAEAIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVK 143
VTE+AA AI+ HNVGIKCATITPDEARVKEF LKKMWKSPNGTIRNIL GTVFREPI++
Sbjct: 127 VTEEAAYAIKEHNVGIKCATITPDEARVKEFGLKKMWKSPNGTIRNILNGTVFREPIVIS 186
Query: 144 NVPRVVPQWSEPIIVGRHAYGDQYKATESLF-PPGRLELVHTPANGGSPQVLEVFNFKGE 202
N+PR+VP W++PI+VGRHA+GDQYKAT+ + PG+LE++ TPA GG+P+ EV++F+G
Sbjct: 187 NIPRLVPGWTKPIVVGRHAFGDQYKATDFVVDGPGKLEMIFTPAAGGAPRKFEVYSFEGP 246
Query: 203 GVGLAMYNTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYR 262
GV + MYNT ES+ FA SCFEYA+ +R+PL LSTKNTILK YDG FL+ F Y+T+Y+
Sbjct: 247 GVAMGMYNTEESIRGFASSCFEYALQKRWPLYLSTKNTILKSYDGRFLQIFAETYETQYK 306
Query: 263 EQFERLNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLL 322
+Q+E + Y HRLIDD VAQ +K +GGFVWACKNYDGDVQSDIVAQG+GSLGLMTSVL+
Sbjct: 307 KQYEEAGIWYEHRLIDDMVAQGLKSSGGFVWACKNYDGDVQSDIVAQGYGSLGLMTSVLV 366
Query: 323 CPDGKTIESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFA 382
PDGKT+E+EAAHGTVTRH+RE+QKGK TSTN VASIFAWTRGLAHRGKLD NA L+++
Sbjct: 367 TPDGKTVEAEAAHGTVTRHWREYQKGKPTSTNPVASIFAWTRGLAHRGKLDNNAELIQWT 426
Query: 383 SSLERATIKTIEGGHMTKDLALCVHGAAALQRSHYETTEVFIDSVAEELARSVKG 437
LE A I+TIE GHMTKDLA+CVHG + Y TE F+D+VA+ A+ G
Sbjct: 427 HDLEAAVIETIEQGHMTKDLAICVHGTTKVTPDQYLNTEPFMDAVADTFAKKRGG 481
>ref|NP_001004799.1| MGC69505 protein [Xenopus tropicalis]
gb|AAH74545.1| MGC69505 protein [Xenopus tropicalis]
Length = 455
Score = 693 bits (1790), Expect = 0.0, Method: Composition-based stats.
Identities = 266/440 (60%), Positives = 332/440 (75%), Gaps = 8/440 (1%)
Query: 4 RVACAASSVNAGALTPRF-----VSTTRPSLGRIKVSGTVVDMDGDEMTRIIWALIKEKL 58
R + AA N G L P + RIKV+ VV+MDGDEMTRIIW IKEKL
Sbjct: 13 RASAAALGKNPGVLAPALSQQQLQQQRNYADKRIKVANPVVEMDGDEMTRIIWEFIKEKL 72
Query: 59 ILPHVDVPIEYYDLSITSRDASNDKVTEQAAEAIQRHNVGIKCATITPDEARVKEFNLKK 118
IL +VDV ++Y+DL + RD +ND+VT +A A ++NV +KCATITPDEARV+EF LKK
Sbjct: 73 ILSNVDVELKYFDLGLPYRDQTNDQVTIDSALATLKYNVAVKCATITPDEARVEEFKLKK 132
Query: 119 MWKSPNGTIRNILGGTVFREPIIVKNVPRVVPQWSEPIIVGRHAYGDQYKATESLF-PPG 177
MWKSPNGTIRNILGGTVFR+PII KN+PR+VP W++ I +GRHA+GDQYKAT+ + G
Sbjct: 133 MWKSPNGTIRNILGGTVFRDPIICKNIPRLVPGWTQAITIGRHAHGDQYKATDFVVDQAG 192
Query: 178 RLELVHTPANGGSPQVLEVFNFKGEGVGLAMYNTRESVEAFAESCFEYAIMRRYPLVLST 237
+LV PANG + + EVFNF GVG+ MYNT ES+ FA SCF+Y+I +++PL LST
Sbjct: 193 TFKLVFAPANGTATKEWEVFNFPAGGVGMGMYNTDESISGFAHSCFQYSIQKKWPLYLST 252
Query: 238 KNTILKKYDGLFLETFQRMYDTKYREQFERLNLTYVHRLIDDQVAQMIKGNGGFVWACKN 297
KNTILK YDG F + FQ +++ Y+ +F++L + Y HRLIDD VAQ++K GGFVWACKN
Sbjct: 253 KNTILKAYDGRFKDIFQDIFEKHYKPEFDKLKIWYEHRLIDDMVAQVLKSTGGFVWACKN 312
Query: 298 YDGDVQSDIVAQGFGSLGLMTSVLLCPDGKTIESEAAHGTVTRHYREHQKGKETSTNSVA 357
YDGDVQSDI+AQGFGSLGLMTSVL+CPDGKTIE+EAAHGTVTRHYREHQKG+ TSTN +A
Sbjct: 313 YDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIA 372
Query: 358 SIFAWTRGLAHRGKLDGNAPLVEFASSLERATIKTIEGGHMTKDLALCVHGAAALQR--S 415
SIFAWTRGL HRGKLDGN L+ F+ +LE+ ++T+E G MTKDLA C+HG + R
Sbjct: 373 SIFAWTRGLEHRGKLDGNQDLINFSLTLEKVCVETVESGIMTKDLAGCIHGGMSNVRLNE 432
Query: 416 HYETTEVFIDSVAEELARSV 435
HY T F+D++ L +++
Sbjct: 433 HYVNTTDFLDAIKNNLDKAL 452
>sp|O88844|IDHC_MOUSE Isocitrate dehydrogenase [NADP] cytoplasmic (Cytosolic
NADP-isocitrate dehydrogenase) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP)
gb|AAD02919.1| NADP-dependent isocitrate dehydrogenase [Mus musculus]
Length = 414
Score = 693 bits (1790), Expect = 0.0, Method: Composition-based stats.
Identities = 258/410 (62%), Positives = 318/410 (77%), Gaps = 2/410 (0%)
Query: 29 LGRIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQA 88
+ R G+VV+M GDEMTRIIW LIKEKLILP+V++ + YDL I +RDA+ND+VT+ A
Sbjct: 1 MSRKIQGGSVVEMQGDEMTRIIWELIKEKLILPYVELDLHSYDLGIENRDATNDQVTKDA 60
Query: 89 AEAIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRV 148
AEAI+++NVG+KCATITPDE RV+EF LK+MWKSPNGTIRNILGGTVFRE II KN+PR+
Sbjct: 61 AEAIKKYNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 149 VPQWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNFK-GEGVGL 206
V W +PII+GRHAYGDQY+AT+ + P PG++E+ +TP +G V +F+ G GV +
Sbjct: 121 VTGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPKDGTQKVTYMVHDFEEGGGVAM 180
Query: 207 AMYNTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFE 266
MYN +S+E FA S F+ A+ + +PL LSTKNTILKKYDG F + FQ +YD KY+ QFE
Sbjct: 181 GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKKYKSQFE 240
Query: 267 RLNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDG 326
N+ Y HRLIDD VAQ +K GGF+WACKNYDGDVQSD VAQG+GSLG+MTSVL+CPDG
Sbjct: 241 AQNICYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDG 300
Query: 327 KTIESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLE 386
KT+E+EAAHGTVTRHYR +QKG+ETSTN +ASIFAW+RGLAHR KLD N L FA +LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWSRGLAHRAKLDNNTELSFFAKALE 360
Query: 387 RATIKTIEGGHMTKDLALCVHGAAALQRSHYETTEVFIDSVAEELARSVK 436
I+TIE G MTKDLA C+ G +QRS Y T F+D + E L +
Sbjct: 361 DVCIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKAKLA 410
>emb|CAG38738.1| IDH1 [Homo sapiens]
Length = 414
Score = 693 bits (1790), Expect = 0.0, Method: Composition-based stats.
Identities = 257/410 (62%), Positives = 319/410 (77%), Gaps = 2/410 (0%)
Query: 29 LGRIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQA 88
+ + G+VV+M GDEMTRIIW LIKEKLI P+V++ + YDL I +RDA+ND+VT+ A
Sbjct: 1 MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDA 60
Query: 89 AEAIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRV 148
AEAI++HNVG+KCATITPDE RV+EF LK+MWKSPNGTIRNILGGTVFRE II KN+PR+
Sbjct: 61 AEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 149 VPQWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNFK-GEGVGL 206
V W +PII+GRHAYGDQY+AT+ + P PG++E+ +TP++G V NF+ G GV +
Sbjct: 121 VSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEMTYTPSDGTQKVTYLVHNFEEGGGVAM 180
Query: 207 AMYNTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFE 266
MYN +S+E FA S F+ A+ + +PL LSTKNTILKKYDG F + FQ +YD +Y+ QFE
Sbjct: 181 GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE 240
Query: 267 RLNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDG 326
+ Y HRLIDD VAQ +K GGF+WACKNYDGDVQSD VAQG+GSLG+MTSVL+CPDG
Sbjct: 241 AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG 300
Query: 327 KTIESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLE 386
KT+E+EAAHGTVTRHYR +QKG+ETSTN +ASIFAWTRGLAHR KLD N L FA++LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALE 360
Query: 387 RATIKTIEGGHMTKDLALCVHGAAALQRSHYETTEVFIDSVAEELARSVK 436
+I+TIE G MTKDLA C+ G +QRS Y T F+D + E L +
Sbjct: 361 EVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLA 410
Searching..................................................done
Results from round 3
Score E
Sequences producing significant alignments: (bits) Value
Sequences used in model and found again:
ref|NP_955858.1| isocitrate dehydrogenase 2 (NADP+), mitoch... 736 0.0
ref|NP_786984.1| isocitrate dehydrogenase 2 (NADP+), mitoch... 736 0.0
gb|ABE98244.1| mitochondrial isocitrate dehydrogenase 2-lik... 736 0.0
ref|NP_001026770.1| hypothetical protein LOC431056 [Gallus ... 735 0.0
sp|Q04467|IDHP_BOVIN Isocitrate dehydrogenase [NADP], mitoc... 734 0.0
ref|XP_536192.2| PREDICTED: similar to isocitrate dehydroge... 731 0.0
gb|ACO14046.1| Isocitrate dehydrogenase, mitochondrial prec... 730 0.0
ref|XP_510589.2| PREDICTED: isocitrate dehydrogenase 2 (NAD... 729 0.0
sp|P54071|IDHP_MOUSE Isocitrate dehydrogenase [NADP], mitoc... 729 0.0
ref|XP_001095686.1| PREDICTED: isocitrate dehydrogenase 2 (... 729 0.0
ref|NP_002159.2| isocitrate dehydrogenase 2 (NADP+), mitoch... 729 0.0
ref|XP_001369305.1| PREDICTED: hypothetical protein [Monode... 728 0.0
sp|P33198|IDHP_PIG Isocitrate dehydrogenase [NADP], mitocho... 728 0.0
emb|CAA49208.1| isocitrate dehydrogenase (NADP+) [Homo sapi... 728 0.0
ref|NP_766599.1| isocitrate dehydrogenase 2 (NADP+), mitoch... 728 0.0
ref|NP_001014183.1| isocitrate dehydrogenase 2 (NADP+), mit... 727 0.0
pdb|1LWD|A Chain A, Crystal Structure Of Nadp-Dependent Iso... 727 0.0
dbj|BAD96636.1| isocitrate dehydrogenase 2 (NADP+), mitocho... 727 0.0
gb|EAX02083.1| isocitrate dehydrogenase 2 (NADP+), mitochon... 725 0.0
ref|XP_001168316.1| PREDICTED: isocitrate dehydrogenase 2 (... 723 0.0
ref|NP_001080321.1| hypothetical protein LOC380013 [Xenopus... 721 0.0
ref|XP_001168291.1| PREDICTED: isocitrate dehydrogenase 2 (... 720 0.0
emb|CAG13105.1| unnamed protein product [Tetraodon nigrovir... 719 0.0
ref|NP_970434.1| isocitrate dehydrogenase [Bdellovibrio bac... 718 0.0
ref|XP_001107627.1| PREDICTED: isocitrate dehydrogenase 1 (... 718 0.0
ref|XP_847200.1| isocitrate dehydrogenase [NADP], mitochond... 717 0.0
ref|NP_001004799.1| MGC69505 protein [Xenopus tropicalis] >... 716 0.0
ref|NP_113698.1| isocitrate dehydrogenase 1 (NADP+), solubl... 716 0.0
dbj|BAC77065.1| NADP-specific isocitrate dehydrogenase [Lup... 716 0.0
ref|NP_001088022.1| hypothetical protein LOC494713 [Xenopus... 716 0.0
emb|CAG02362.1| unnamed protein product [Tetraodon nigrovir... 715 0.0
sp|Q9Z2K9|IDHC_MICME Isocitrate dehydrogenase [NADP] cytopl... 715 0.0
ref|XP_421965.2| PREDICTED: similar to cytosolic NADP-depen... 715 0.0
ref|XP_850187.1| PREDICTED: similar to Isocitrate dehydroge... 715 0.0
emb|CAG38738.1| IDH1 [Homo sapiens] 715 0.0
ref|NP_851355.2| isocitrate dehydrogenase 1 (NADP+), solubl... 714 0.0
ref|XP_001168261.1| PREDICTED: isocitrate dehydrogenase 2 (... 714 0.0
sp|Q9Z2K8|IDHC_MICOH Isocitrate dehydrogenase [NADP] cytopl... 714 0.0
gb|ABU41004.1| isocitrate dehydrogenase 1 [Anser anser] 714 0.0
ref|NP_005887.2| isocitrate dehydrogenase 1 (NADP+), solubl... 714 0.0
ref|XP_001141655.1| PREDICTED: isocitrate dehydrogenase 1 (... 713 0.0
sp|Q5R9C5|IDHC_PONPY Isocitrate dehydrogenase [NADP] cytopl... 713 0.0
ref|XP_001778805.1| predicted protein [Physcomitrella paten... 713 0.0
ref|NP_539708.1| isocitrate dehydrogenase [Brucella meliten... 713 0.0
emb|CAH89719.1| hypothetical protein [Pongo abelii] 713 0.0
ref|NP_001009276.1| cytosolic NADP-isocitrate dehydrogenase... 713 0.0
ref|NP_698203.1| isocitrate dehydrogenase [Brucella suis 13... 713 0.0
emb|CAA53300.1| isocitrate dehydrogenase (NADP+) [Solanum t... 713 0.0
gb|ABF20272.1| mitochondrial isocitrate dehydrogenase [Leis... 713 0.0
gb|AAH93020.1| Isocitrate dehydrogenase 1 (NADP+), soluble ... 712 0.0
ref|NP_001056381.1| Os05g0573200 [Oryza sativa (japonica cu... 712 0.0
ref|XP_860821.1| PREDICTED: similar to Isocitrate dehydroge... 711 0.0
sp|Q9XSG3|IDHC_BOVIN Isocitrate dehydrogenase [NADP] cytopl... 711 0.0
emb|CAD97653.1| hypothetical protein [Homo sapiens] >gi|117... 711 0.0
dbj|BAC39792.1| unnamed protein product [Mus musculus] 711 0.0
ref|XP_001505172.1| PREDICTED: similar to Isocitrate dehydr... 710 0.0
ref|ZP_01885694.1| isocitrate dehydrogenase [Pedobacter sp.... 710 0.0
emb|CAM77136.1| Isocitrate/isopropylmalate dehydrogenase [M... 710 0.0
emb|CAB66637.1| hypothetical protein [Homo sapiens] >gi|117... 710 0.0
gb|AAB39248.1| NADP-isocitrate dehydrogenase [Eucalyptus gl... 710 0.0
ref|NP_001043749.1| Os01g0654500 [Oryza sativa (japonica cu... 710 0.0
sp|O88844|IDHC_MOUSE Isocitrate dehydrogenase [NADP] cytopl... 710 0.0
sp|Q40345|IDHP_MEDSA Isocitrate dehydrogenase [NADP], chlor... 709 0.0
emb|CAH91635.1| hypothetical protein [Pongo abelii] 709 0.0
ref|XP_970446.1| PREDICTED: similar to isocitrate dehydroge... 709 0.0
ref|NP_034627.3| isocitrate dehydrogenase 1 (NADP+), solubl... 709 0.0
pdb|2CMJ|A Chain A, Crystal Structure Of Mouse Cytosolic Is... 708 0.0
dbj|BAE39644.1| unnamed protein product [Mus musculus] 708 0.0
gb|AAH88986.1| Isocitrate dehydrogenase 1 (NADP+), soluble ... 708 0.0
ref|XP_001511049.1| PREDICTED: similar to cytosolic NADP-de... 708 0.0
ref|XP_001240510.1| isocitrate dehydrogenase NADP, mitochon... 708 0.0
prf||2211361A isocitrate dehydrogenase 708 0.0
gb|AAC52473.1| isocitrate dehydrogenase 708 0.0
gb|AAA33978.1| NADPH-specific isocitrate dehydrogenase 707 0.0
gb|AAD02918.1| NADP-dependent isocitrate dehydrogenase [Hom... 707 0.0
ref|XP_001688948.1| AGAP006660-PA [Anopheles gambiae str. P... 707 0.0
ref|YP_677841.1| isocitrate dehydrogenase [Cytophaga hutchi... 707 0.0
ref|ZP_00056387.1| COG0538: Isocitrate dehydrogenases [Magn... 707 0.0
dbj|BAA34112.1| NADP specific isocitrate dehydrogenase [Dau... 706 0.0
ref|XP_001841910.1| isocitrate dehydrogenase cytoplasmic [C... 706 0.0
pir||S33612 isocitrate dehydrogenase (NADP) (EC 1.1.1.42) -... 706 0.0
dbj|BAE48792.1| NADP-isocitrate dehydrogenase [Codonopsis l... 706 0.0
dbj|BAC77063.1| NADP-specific isocitrate dehydrogenase [Lup... 706 0.0
emb|CAG38553.1| IDH1 [Homo sapiens] 706 0.0
ref|XP_001365492.1| PREDICTED: similar to cytosolic NADP-de... 706 0.0
gb|AAD51361.1|AF176669_1 NADP-isocitrate dehydrogenase [Cit... 706 0.0
ref|YP_419971.1| isocitrate dehydrogenase [Magnetospirillum... 705 0.0
gb|AAC64182.1| NADP-dependent isocitrate dehydrogenase [Gly... 705 0.0
ref|YP_001370537.1| isocitrate dehydrogenase, NADP-dependen... 705 0.0
ref|XP_860853.1| PREDICTED: similar to Isocitrate dehydroge... 705 0.0
ref|XP_001698704.1| isocitrate dehydrogenase, NADP-dependen... 705 0.0
ref|NP_196963.2| isocitrate dehydrogenase, putative / NADP+... 704 0.0
sp|P50217|IDHC_SOLTU Isocitrate dehydrogenase [NADP] (Oxalo... 704 0.0
sp|P50218|IDHC_TOBAC Isocitrate dehydrogenase [NADP] (Oxalo... 704 0.0
ref|XP_001176537.1| PREDICTED: similar to Isocitrate dehydr... 704 0.0
ref|XP_312860.4| AGAP003168-PA [Anopheles gambiae str. PEST... 704 0.0
emb|CAA73139.1| isocitrate dehydrogenase (NADP+) [Apium gra... 703 0.0
ref|XP_754749.1| isocitrate dehydrogenase Idp1 [Aspergillus... 703 0.0
gb|EDP52872.1| isocitrate dehydrogenase Idp1, putative [Asp... 703 0.0
ref|XP_968850.1| PREDICTED: similar to CG7176-PC, isoform C... 703 0.0
emb|CAA65503.1| isocitrate dehydrogenase (NADP+) [Nicotiana... 703 0.0
ref|XP_001650675.1| nadp-specific isocitrate dehydrogenase ... 703 0.0
ref|NP_958907.1| isocitrate dehydrogenase 1 (NADP+), solubl... 703 0.0
emb|CAQ15240.1| isocitrate dehydrogenase 1 (NADP+), soluble... 703 0.0
gb|AAK76730.1| mitochondrial NADP-dependent isocitrate dehy... 703 0.0
ref|ZP_02124492.1| Isocitrate dehydrogenase (NADP(+)) [Meth... 703 0.0
sp|Q06197|IDHC_SOYBN Isocitrate dehydrogenase [NADP] (Oxalo... 703 0.0
emb|CAA65504.1| isocitrate dehydrogenase (NADP+) [Nicotiana... 703 0.0
ref|YP_002826161.1| NADP isocitrate dehydrogenase [Rhizobiu... 702 0.0
gb|AAL11503.1|AF367443_1 NADP-dependent isocitrate dehydrog... 702 0.0
ref|NP_385898.1| isocitrate dehydrogenase [Sinorhizobium me... 702 0.0
ref|XP_001633903.1| predicted protein [Nematostella vectens... 701 0.0
ref|ZP_03891012.1| isocitrate dehydrogenase (NADP) [Geoderm... 701 0.0
dbj|BAC77064.1| NADP-specific isocitrate dehydrogenase [Lup... 701 0.0
gb|ABA18651.1| cytosolic NADP+-isocitrate dehydrogenase [Po... 701 0.0
gb|AAF73472.1|AF268076_1 NADP-dependent isocitrate dehydrog... 700 0.0
dbj|BAA34113.1| NADP specific isocitrate dehydrogenase [Dau... 700 0.0
gb|ABF20244.1| mitochondrial isocitrate dehydrogenase [Leis... 700 0.0
ref|NP_175836.1| ICDH; isocitrate dehydrogenase (NADP+) [Ar... 700 0.0
ref|XP_001463680.1| isocitrate dehydrogenase [NADP], mitoch... 700 0.0
ref|YP_673828.1| isocitrate dehydrogenase [Mesorhizobium sp... 700 0.0
ref|YP_001327198.1| isocitrate dehydrogenase [Sinorhizobium... 700 0.0
gb|EEJ98364.1| isocitrate dehydrogenase (NADP) [Thermomonos... 699 0.0
emb|CAG02627.1| unnamed protein product [Tetraodon nigrovir... 699 0.0
ref|ZP_02188085.1| Isocitrate dehydrogenase [alpha proteoba... 699 0.0
emb|CAA63220.1| isocitrate dehydrogenase (NAD+) [Solanum tu... 699 0.0
gb|ABK24873.1| unknown [Picea sitchensis] 699 0.0
ref|NP_421325.1| isocitrate dehydrogenase [Caulobacter cres... 698 0.0
emb|CAN72808.1| hypothetical protein [Vitis vinifera] >gi|1... 698 0.0
emb|CAD24779.1| isocitrate dehydrogenase [Cucumis sativus] 698 0.0
gb|AAS49171.1| NADP-dependent isocitrate dehydrogenase [Pis... 698 0.0
ref|NP_101923.1| isocitrate dehydrogenase [Mesorhizobium lo... 698 0.0
ref|XP_001681361.1| isocitrate dehydrogenase [NADP], mitoch... 698 0.0
gb|EAY99113.1| hypothetical protein OsI_020346 [Oryza sativ... 698 0.0
ref|YP_290624.1| isocitrate dehydrogenase [Thermobifida fus... 697 0.0
ref|XP_955850.1| hypothetical protein NCU03857 [Neurospora ... 697 0.0
ref|XP_001778590.1| predicted protein [Physcomitrella paten... 697 0.0
gb|AAR05796.1| NADP+-isocitrate dehydrogenase [Pinus pinaster] 697 0.0
ref|ZP_02166681.1| isocitrate dehydrogenase [Hoeflea photot... 697 0.0
ref|YP_001685152.1| isocitrate dehydrogenase, NADP-dependen... 697 0.0
sp|P79089|IDHP_ASPNG Isocitrate dehydrogenase [NADP], mitoc... 697 0.0
ref|YP_001413846.1| isocitrate dehydrogenase, NADP-dependen... 697 0.0
ref|XP_821599.1| isocitrate dehydrogenase, putative [Trypan... 696 0.0
gb|AAV33246.1| isocitrate dehydrogenase [Toxoplasma gondii] 696 0.0
emb|CAB87626.1| isocitrate dehydrogenase-like protein [Arab... 696 0.0
ref|YP_001524781.1| NADP-dependent isocitrate dehydrogenase... 696 0.0
gb|ABF20271.1| mitochondrial isocitrate dehydrogenase [Leis... 695 0.0
ref|YP_001296741.1| isocitrate dehydrogenase [Flavobacteriu... 695 0.0
gb|EDT29808.1| isocitrate dehydrogenase, NADP-dependent [Ol... 695 0.0
ref|XP_001562802.1| isocitrate dehydrogenase [NADP], mitoch... 695 0.0
gb|AAT06312.1| isocitrate dehydrogenase [Rhizobium legumino... 695 0.0
ref|YP_001609735.1| NADP-dependent isocitrate dehydrogenase... 694 0.0
gb|ACO14957.1| Isocitrate dehydrogenase cytoplasmic [Caligu... 694 0.0
ref|YP_768215.1| isocitrate dehydrogenase [Rhizobium legumi... 694 0.0
ref|XP_001226620.1| conserved hypothetical protein [Chaetom... 694 0.0
ref|XP_001384028.1| Isocitrate dehydrogenase [NADP], mitoch... 694 0.0
ref|ZP_03896321.1| isocitrate dehydrogenase (NADP) [Dyadoba... 694 0.0
ref|ZP_02295934.1| isocitrate dehydrogenase, NADP-dependent... 694 0.0
ref|YP_425448.1| isocitrate dehydrogenase [Rhodospirillum r... 694 0.0
ref|YP_001769504.1| isocitrate dehydrogenase, NADP-dependen... 693 0.0
ref|NP_354851.2| isocitrate dehydrogenase [Agrobacterium tu... 693 0.0
ref|ZP_02858718.1| isocitrate dehydrogenase, NADP-dependent... 693 0.0
ref|XP_001845030.1| isocitrate dehydrogenase [Culex pipiens... 693 0.0
ref|XP_451683.1| unnamed protein product [Kluyveromyces lac... 693 0.0
ref|XP_001903959.1| unnamed protein product [Podospora anse... 693 0.0
gb|AAT44354.1| isocitrate dehydrogenase [Crassostrea gigas] 692 0.0
ref|XP_001608101.1| PREDICTED: similar to isocitrate dehydr... 692 0.0
ref|XP_660603.1| IDHP_ASPNG ISOCITRATE DEHYDROGENASE [NADP]... 691 0.0
ref|NP_001040134.1| isocitrate dehydrogenase [Bombyx mori] ... 691 0.0
ref|NP_176768.1| isocitrate dehydrogenase, putative / NADP+... 691 0.0
ref|XP_623673.2| PREDICTED: similar to Isocitrate dehydroge... 691 0.0
ref|YP_001419447.1| isocitrate dehydrogenase, NADP-dependen... 691 0.0
ref|YP_872148.1| isocitrate dehydrogenase [Acidothermus cel... 690 0.0
gb|ABI52605.1| isocitrate dehydrogenase [Gryllus firmus] 690 0.0
gb|AAM13090.1| similar to NADP-specific isocitrate dehydrog... 690 0.0
ref|YP_706173.1| isocitrate dehydrogenase [Rhodococcus sp. ... 690 0.0
emb|CAD24782.1| isocitrate dehydrogenase [Arabidopsis thali... 690 0.0
ref|XP_001400371.1| precursor of mitochondrial isocitrate d... 689 0.0
ref|NP_001042583.1| Os01g0248400 [Oryza sativa (japonica cu... 689 0.0
gb|AAK76731.1| peroxisomal NADP-dependent isocitrate dehydr... 689 0.0
ref|XP_001593497.1| hypothetical protein SS1G_04924 [Sclero... 688 0.0
ref|YP_117132.1| isocitrate dehydrogenase [Nocardia farcini... 688 0.0
ref|YP_002761841.1| NADP-dependent isocitrate dehydrogenase... 688 0.0
ref|NP_001093090.1| NADPH-specific isocitrate dehydrogenase... 688 0.0
ref|NP_001053269.1| Os04g0508200 [Oryza sativa (japonica cu... 687 0.0
gb|AAM65674.1| isocitrate dehydrogenase, putative [Arabidop... 687 0.0
ref|XP_001676039.1| Hypothetical protein CBG17397 [Caenorha... 687 0.0
ref|YP_001538953.1| isocitrate dehydrogenase, NADP-dependen... 686 0.0
ref|ZP_00952302.1| isocitrate dehydrogenase [Oceanicaulis a... 686 0.0
ref|XP_001670101.1| Hypothetical protein CBG21657 [Caenorha... 686 0.0
ref|XP_001263574.1| isocitrate dehydrogenase Idp1, putative... 686 0.0
emb|CAE04728.1| OSJNBa0043L24.16 [Oryza sativa (japonica cu... 685 0.0
ref|YP_682929.1| isocitrate dehydrogenase [Roseobacter deni... 685 0.0
ref|ZP_01228834.1| NADP dependent isocitrate dehydrogenase ... 685 0.0
ref|YP_001160602.1| isocitrate dehydrogenase [Salinispora t... 685 0.0
emb|CAO64975.1| unnamed protein product [Vitis vinifera] 685 0.0
ref|YP_032403.1| isocitrate dehydrogenase [Bartonella quint... 685 0.0
ref|NP_772387.1| isocitrate dehydrogenase [Bradyrhizobium j... 685 0.0
ref|XP_710919.1| NADP-specific isocitrate dehydrogenase [Ca... 684 0.0
ref|YP_001709366.1| isocitrate dehydrogenase [Clavibacter m... 684 0.0
ref|YP_033790.1| isocitrate dehydrogenase [Bartonella hense... 684 0.0
ref|ZP_01440188.1| Isocitrate/isopropylmalate dehydrogenase... 684 0.0
ref|ZP_03869030.1| isocitrate dehydrogenase (NADP) [Jonesia... 684 0.0
ref|YP_001223282.1| isocitrate dehydrogenase [Clavibacter m... 684 0.0
emb|CAH67563.1| OSIGBa0101P20.6 [Oryza sativa (indica culti... 684 0.0
ref|XP_390523.1| hypothetical protein FG10347.1 [Gibberella... 684 0.0
ref|YP_001233708.1| isocitrate dehydrogenase [Acidiphilium ... 684 0.0
ref|XP_001528456.1| isocitrate dehydrogenase, mitochondrial... 683 0.0
ref|YP_001832264.1| isocitrate dehydrogenase, NADP-dependen... 683 0.0
ref|XP_001462393.1| hypothetical protein GSPATT00027349001 ... 683 0.0
ref|YP_002783489.1| isocitrate dehydrogenase [Rhodococcus o... 683 0.0
ref|YP_496560.1| isocitrate dehydrogenase [Novosphingobium ... 683 0.0
ref|ZP_03819206.1| isocitrate dehydrogenase (NADP) [Actinos... 683 0.0
ref|ZP_02955422.1| isocitrate dehydrogenase, NADP-dependent... 683 0.0
ref|YP_062774.1| isocitrate dehydrogenase [Leifsonia xyli s... 683 0.0
ref|XP_001818331.1| hypothetical protein [Aspergillus oryza... 683 0.0
ref|YP_617009.1| isocitrate dehydrogenase [Sphingopyxis ala... 682 0.0
ref|XP_001020930.2| dehydrogenase, isocitrate/isopropylmala... 682 0.0
gb|EAY58582.1| isocitrate dehydrogenase [NADP] icd1 [Mycoba... 682 0.0
ref|YP_002765452.1| NADP-dependent isocitrate dehydrogenase... 682 0.0
ref|NP_509875.1| C34F6.8 [Caenorhabditis elegans] >gi|38747... 682 0.0
ref|YP_989041.1| isocitrate dehydrogenase [Bartonella bacil... 682 0.0
ref|XP_001837820.1| hypothetical protein CC1G_11465 [Coprin... 682 0.0
ref|ZP_01862723.1| isocitrate dehydrogenase [Erythrobacter ... 682 0.0
ref|ZP_01546031.1| isocitrate dehydrogenase [Stappia aggreg... 681 0.0
ref|XP_001454244.1| hypothetical protein GSPATT00020509001 ... 681 0.0
ref|XP_001457045.1| hypothetical protein GSPATT00022820001 ... 681 0.0
ref|XP_813368.1| isocitrate dehydrogenase [NADP], mitochond... 681 0.0
ref|XP_001270886.1| isocitrate dehydrogenase Idp1, putative... 681 0.0
ref|ZP_01303522.1| isocitrate dehydrogenase, NADP-dependent... 681 0.0
ref|XP_001426548.1| hypothetical protein GSPATT00029781001 ... 681 0.0
ref|YP_001363715.1| isocitrate dehydrogenase, NADP-dependen... 681 0.0
ref|YP_001833636.1| isocitrate dehydrogenase, NADP-dependen... 680 0.0
ref|NP_217856.1| isocitrate dehydrogenase [Mycobacterium tu... 680 0.0
ref|ZP_00954676.1| isocitrate dehydrogenase [Sulfitobacter ... 680 0.0
ref|ZP_01040029.1| isocitrate dehydrogenase [Erythrobacter ... 680 0.0
ref|ZP_00964081.1| isocitrate dehydrogenase [Sulfitobacter ... 679 0.0
ref|XP_459772.1| hypothetical protein DEHA0E11286g [Debaryo... 679 0.0
ref|NP_010217.1| Mitochondrial NADP-specific isocitrate deh... 679 0.0
ref|YP_001758392.1| isocitrate dehydrogenase, NADP-dependen... 679 0.0
ref|XP_504978.1| hypothetical protein [Yarrowia lipolytica]... 679 0.0
ref|YP_001623415.1| isocitrate dehydrogenase (NADP) [Reniba... 678 0.0
ref|YP_756242.1| isocitrate dehydrogenase [Maricaulis maris... 678 0.0
ref|YP_979491.1| isocitrate dehydrogenase [Mycobacterium bo... 678 0.0
ref|YP_001169228.1| isocitrate dehydrogenase [Rhodobacter s... 678 0.0
ref|NP_949171.1| isocitrate dehydrogenase [Rhodopseudomonas... 678 0.0
ref|YP_001108727.1| isocitrate dehydrogenase [Saccharopolys... 678 0.0
ref|YP_001204807.1| isocitrate dehydrogenase [Bradyrhizobiu... 678 0.0
gb|ABO93633.1| isocitrate dehydrogenase 2 [Toxoplasma gondii] 677 0.0
ref|YP_458429.1| isocitrate dehydrogenase [Erythrobacter li... 677 0.0
ref|YP_001849499.1| isocitrate dehydrogenase [NADP] Icd1 [M... 677 0.0
ref|YP_001168561.1| isocitrate dehydrogenase [Rhodobacter s... 677 0.0
ref|YP_001241304.1| isocitrate dehydrogenase [Bradyrhizobiu... 677 0.0
gb|ABL97438.1| isocitrate dehydrogenase [uncultured marine ... 676 0.0
ref|XP_001878769.1| predicted protein [Laccaria bicolor S23... 676 0.0
sp|P50215|IDH_SPHYA Isocitrate dehydrogenase [NADP] (Oxalos... 676 0.0
gb|ABK25438.1| unknown [Picea sitchensis] 676 0.0
ref|NP_501665.1| F59B8.2 [Caenorhabditis elegans] >gi|38778... 676 0.0
ref|NP_729366.1| Isocitrate dehydrogenase CG7176-PB, isofor... 676 0.0
ref|YP_001043974.1| isocitrate dehydrogenase [Rhodobacter s... 676 0.0
ref|ZP_02302766.1| isocitrate dehydrogenase, NADP-dependent... 675 0.0
ref|YP_001042101.1| isocitrate dehydrogenase [Rhodobacter s... 675 0.0
ref|XP_569234.1| isocitrate dehydrogenase (NADP+) [Cryptoco... 675 0.0
ref|YP_487337.1| isocitrate dehydrogenase [Rhodopseudomonas... 675 0.0
sp|O13285|IDH1_CANTR Isocitrate dehydrogenase [NADP], mitoc... 675 0.0
ref|XP_367343.2| hypothetical protein MGG_07268 [Magnaporth... 674 0.0
ref|XP_645284.1| isocitrate dehydrogenase (NADP+) [Dictyost... 674 0.0
ref|YP_353519.1| isocitrate dehydrogenase [Rhodobacter spha... 674 0.0
ref|XP_569233.1| isocitrate dehydrogenase (NADP+) [Cryptoco... 674 0.0
ref|YP_568874.1| isocitrate dehydrogenase [Rhodopseudomonas... 674 0.0
ref|ZP_01130474.1| isocitrate dehydrogenase [marine actinob... 673 0.0
ref|YP_351602.1| isocitrate dehydrogenase [Rhodobacter spha... 673 0.0
gb|ABD77209.1| isocitrate dehydrogenase 1 [Rattus norvegicus] 673 0.0
ref|YP_001601185.1| Isocitrate dehydrogenase [Gluconacetoba... 673 0.0
ref|XP_001354101.1| GA20156-PA [Drosophila pseudoobscura] >... 672 0.0
ref|XP_001507484.1| PREDICTED: similar to isocitrate dehydr... 672 0.0
ref|ZP_01046178.1| isocitrate dehydrogenase NADP-dependent ... 671 0.0
ref|ZP_02981592.1| isocitrate dehydrogenase, NADP-dependent... 671 0.0
ref|XP_001614236.1| isocitrate dehydrogenase [NADP], mitoch... 671 0.0
ref|YP_001260963.1| isocitrate dehydrogenase [Sphingomonas ... 671 0.0
ref|ZP_02963068.1| isocitrate dehydrogenase [Bifidobacteriu... 671 0.0
ref|XP_001484278.1| isocitrate dehydrogenase, mitochondrial... 670 0.0
ref|YP_317907.1| isocitrate dehydrogenase [Nitrobacter wino... 670 0.0
ref|YP_780531.1| isocitrate dehydrogenase [Rhodopseudomonas... 670 0.0
ref|ZP_01448513.1| isocitrate dehydrogenase [alpha proteoba... 670 0.0
ref|ZP_03922528.1| isocitrate dehydrogenase [Mobiluncus cur... 669 0.0
ref|YP_531457.1| isocitrate dehydrogenase [Rhodopseudomonas... 669 0.0
ref|XP_713421.1| cytosolic NADP-specific isocitrate dehydro... 669 0.0
ref|XP_780121.1| PREDICTED: similar to cytosolic NADP-depen... 669 0.0
ref|ZP_00960755.1| Isocitrate dehydrogenase [Roseovarius nu... 669 0.0
ref|XP_001527573.1| isocitrate dehydrogenase peroxisomal [L... 668 0.0
gb|ABD36135.1| isocitrate dehydrogenase precursor [Bombyx m... 668 0.0
ref|YP_909639.1| isocitrate dehydrogenase [Bifidobacterium ... 668 0.0
ref|ZP_01157336.1| isocitrate dehydrogenase [Oceanicola gra... 668 0.0
ref|YP_576902.1| isocitrate dehydrogenase [Nitrobacter hamb... 668 0.0
ref|NP_984921.1| AER061Cp [Ashbya gossypii ATCC 10895] >gi|... 668 0.0
ref|ZP_03813993.1| isocitrate dehydrogenase (NADP) [Beutenb... 668 0.0
ref|YP_266067.1| isocitrate dehydrogenase [Candidatus Pelag... 668 0.0
ref|NP_729367.1| Isocitrate dehydrogenase CG7176-PD, isofor... 667 0.0
ref|XP_445447.1| unnamed protein product [Candida glabrata]... 666 0.0
Sequences not found previously or not previously below threshold:
>ref|NP_955858.1| isocitrate dehydrogenase 2 (NADP+), mitochondrial [Danio rerio]
gb|AAH48041.1| Isocitrate dehydrogenase 2 (NADP+), mitochondrial [Danio rerio]
gb|AAH63967.1| Isocitrate dehydrogenase 2 (NADP+), mitochondrial [Danio rerio]
Length = 449
Score = 736 bits (1902), Expect = 0.0, Method: Composition-based stats.
Identities = 260/437 (59%), Positives = 336/437 (76%), Gaps = 2/437 (0%)
Query: 1 MFRRVACAASSVNAGALTPRFVSTTRPSLGRIKVSGTVVDMDGDEMTRIIWALIKEKLIL 60
+ R A + S A + + + RI+V+ VV+MDGDEMTRIIW IKEKLIL
Sbjct: 11 LSRSAATLSKSPAVLAPACQSLQQRNYADKRIQVAQPVVEMDGDEMTRIIWEFIKEKLIL 70
Query: 61 PHVDVPIEYYDLSITSRDASNDKVTEQAAEAIQRHNVGIKCATITPDEARVKEFNLKKMW 120
+V+V ++YYDL + RD ++D+VT +A A +++NV +KCATITPDEARV+EF LKKMW
Sbjct: 71 TNVNVDLKYYDLGLPYRDQTDDQVTIDSAIATKKYNVAVKCATITPDEARVEEFKLKKMW 130
Query: 121 KSPNGTIRNILGGTVFREPIIVKNVPRVVPQWSEPIIVGRHAYGDQYKATESLF-PPGRL 179
KSPNGTIRNILGGTVFREPII KN+PR+VP W++ I +GRHA+GDQYKAT+ + PG+
Sbjct: 131 KSPNGTIRNILGGTVFREPIICKNIPRLVPGWTQAITIGRHAFGDQYKATDFVVNQPGKF 190
Query: 180 ELVHTPANGGSPQVLEVFNFKGEGVGLAMYNTRESVEAFAESCFEYAIMRRYPLVLSTKN 239
++V TPA+G + EV++F G G G+ MYNT ES+ FA SCF+YAI +++PL +STKN
Sbjct: 191 KMVFTPADGSKNKEWEVYDFPGGGCGMGMYNTDESITGFAHSCFQYAIQKKWPLYMSTKN 250
Query: 240 TILKKYDGLFLETFQRMYDTKYREQFERLNLTYVHRLIDDQVAQMIKGNGGFVWACKNYD 299
TILK YDG F + FQ +++ Y+ +F++L + Y HRLIDD VAQ++K +G FVWACKNYD
Sbjct: 251 TILKAYDGRFKDIFQDIFEKNYKPEFDKLKIWYEHRLIDDMVAQVLKSSGAFVWACKNYD 310
Query: 300 GDVQSDIVAQGFGSLGLMTSVLLCPDGKTIESEAAHGTVTRHYREHQKGKETSTNSVASI 359
GDVQSDI+AQGFGSLGLMTSVL+CPDGKTIE+EAAHGTVTRHYREHQKG+ TSTN +ASI
Sbjct: 311 GDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASI 370
Query: 360 FAWTRGLAHRGKLDGNAPLVEFASSLERATIKTIEGGHMTKDLALCVHGAAALQ-RSHYE 418
FAWTRGL HRGKLDGN L++F+ +LER ++T+E G MTKDLA C+HG A + HY
Sbjct: 371 FAWTRGLEHRGKLDGNPDLIKFSQTLERVCVETVESGVMTKDLAGCIHGLANCKLNEHYV 430
Query: 419 TTEVFIDSVAEELARSV 435
T F+D++ L +++
Sbjct: 431 NTTDFLDAIKTNLDKAL 447
>ref|NP_786984.1| isocitrate dehydrogenase 2 (NADP+), mitochondrial [Bos taurus]
emb|CAA49207.1| isocitrate dehydrogenase (NADP+) [Bos taurus]
Length = 452
Score = 736 bits (1900), Expect = 0.0, Method: Composition-based stats.
Identities = 267/442 (60%), Positives = 339/442 (76%), Gaps = 11/442 (2%)
Query: 4 RVACAASSVNAGALTPRFVS--------TTRPSLGRIKVSGTVVDMDGDEMTRIIWALIK 55
R C AS + A PR ++ + RIKV+ VV+MDGDEMTRIIW IK
Sbjct: 9 RSLCRASG-SGSAWAPRALTAPNLQEQPRRHYADKRIKVAKPVVEMDGDEMTRIIWQFIK 67
Query: 56 EKLILPHVDVPIEYYDLSITSRDASNDKVTEQAAEAIQRHNVGIKCATITPDEARVKEFN 115
EKLILPHVDV ++Y+DL + +RD +ND+VT +A A Q+++V +KCATITPDEARV+EF
Sbjct: 68 EKLILPHVDVQLKYFDLGLPNRDQTNDQVTIDSALATQKYSVAVKCATITPDEARVEEFK 127
Query: 116 LKKMWKSPNGTIRNILGGTVFREPIIVKNVPRVVPQWSEPIIVGRHAYGDQYKATESLFP 175
LKKMWKSPNGTIRNILGGTVFREPII KN+PR+VP W++PI +GRHA+GDQYKAT+ +
Sbjct: 128 LKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYKATDFVVD 187
Query: 176 -PGRLELVHTPANGGSPQVLEVFNFKGEGVGLAMYNTRESVEAFAESCFEYAIMRRYPLV 234
G ++V TP +G P+ EV+NF GVG+ MYNT ES+ FA SCF+YAI +++PL
Sbjct: 188 RAGTFKVVFTPKDGSGPKEWEVYNFPAGGVGMGMYNTDESISGFAHSCFQYAIQKKWPLY 247
Query: 235 LSTKNTILKKYDGLFLETFQRMYDTKYREQFERLNLTYVHRLIDDQVAQMIKGNGGFVWA 294
+STKNTILK YDG F + FQ +++ Y+ +F++ + Y HRLIDD VAQ++K +GGFVWA
Sbjct: 248 MSTKNTILKAYDGRFKDIFQAIFEKHYKTEFDKHKIWYEHRLIDDMVAQVLKSSGGFVWA 307
Query: 295 CKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDGKTIESEAAHGTVTRHYREHQKGKETSTN 354
CKNYDGDVQSDI+AQGFGSLGLMTSVL+CPDGKTIE+EAAHGTVTRHYREHQKG+ TSTN
Sbjct: 308 CKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTN 367
Query: 355 SVASIFAWTRGLAHRGKLDGNAPLVEFASSLERATIKTIEGGHMTKDLALCVHGAAALQ- 413
+ASIFAWTRGL HRGKLDGN L+ FA +LE+ ++T+E G MTKDLA C+HG + ++
Sbjct: 368 PIASIFAWTRGLEHRGKLDGNQDLIRFAQTLEKVCVETVESGAMTKDLAGCIHGLSNVKL 427
Query: 414 RSHYETTEVFIDSVAEELARSV 435
H+ T F+D++ L R++
Sbjct: 428 NEHFLNTSDFLDTIKSNLDRAL 449
>gb|ABE98244.1| mitochondrial isocitrate dehydrogenase 2-like [Oreochromis
mossambicus]
Length = 452
Score = 736 bits (1900), Expect = 0.0, Method: Composition-based stats.
Identities = 262/440 (59%), Positives = 338/440 (76%), Gaps = 6/440 (1%)
Query: 2 FRRVACAASSVNAGALTPR----FVSTTRPSLGRIKVSGTVVDMDGDEMTRIIWALIKEK 57
R A AA S N L P + + RIKV+ VV+MDGDEMTRIIW IKEK
Sbjct: 11 LSRSAGAAFSRNPAVLAPAANCQTLQQRNYADKRIKVANPVVEMDGDEMTRIIWEFIKEK 70
Query: 58 LILPHVDVPIEYYDLSITSRDASNDKVTEQAAEAIQRHNVGIKCATITPDEARVKEFNLK 117
LIL +VDV ++Y+DL + RD ++D+VT +A A ++++V +KCATITPDEARV+EF LK
Sbjct: 71 LILTNVDVELKYFDLGLPYRDQTDDQVTIDSALATKKYSVAVKCATITPDEARVEEFGLK 130
Query: 118 KMWKSPNGTIRNILGGTVFREPIIVKNVPRVVPQWSEPIIVGRHAYGDQYKATESLF-PP 176
KMWKSPNGTIRNILGGTVFREPII KN+PR+VP W++PI +GRHA+GDQY+AT+ + P
Sbjct: 131 KMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTQPITIGRHAFGDQYRATDFVVDQP 190
Query: 177 GRLELVHTPANGGSPQVLEVFNFKGEGVGLAMYNTRESVEAFAESCFEYAIMRRYPLVLS 236
G+ ++V +PA+G + + EVF+F G G+ MYNT ES+ FA SCF+YAI +++PL +S
Sbjct: 191 GKFKIVFSPADGSTSKEWEVFDFPAGGCGMGMYNTDESITGFAHSCFQYAIGKKWPLYMS 250
Query: 237 TKNTILKKYDGLFLETFQRMYDTKYREQFERLNLTYVHRLIDDQVAQMIKGNGGFVWACK 296
TKNTILK YDG F + FQ +++ Y+ +F++L + Y HRLIDD VAQ++K +G FVWACK
Sbjct: 251 TKNTILKAYDGRFKDIFQDIFEKNYKPEFDKLKIWYEHRLIDDMVAQVLKSSGAFVWACK 310
Query: 297 NYDGDVQSDIVAQGFGSLGLMTSVLLCPDGKTIESEAAHGTVTRHYREHQKGKETSTNSV 356
NYDGDVQSDI+AQGFGSLGLMTSVL+CPDGKTIE+EAAHGTVTRHYREHQKG+ TSTN +
Sbjct: 311 NYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPI 370
Query: 357 ASIFAWTRGLAHRGKLDGNAPLVEFASSLERATIKTIEGGHMTKDLALCVHGAAALQ-RS 415
ASIFAWTRGL HRGKLDGN L++FA +LE+ + T+E G MTKDLA C+HG + ++
Sbjct: 371 ASIFAWTRGLEHRGKLDGNPDLIKFAQTLEQVCVATVESGTMTKDLAGCIHGLSNVKLNE 430
Query: 416 HYETTEVFIDSVAEELARSV 435
HY T F+D++ L +++
Sbjct: 431 HYVNTTDFLDAIKTNLDKAL 450
>ref|NP_001026770.1| hypothetical protein LOC431056 [Gallus gallus]
emb|CAG31511.1| hypothetical protein [Gallus gallus]
Length = 452
Score = 735 bits (1897), Expect = 0.0, Method: Composition-based stats.
Identities = 264/438 (60%), Positives = 335/438 (76%), Gaps = 4/438 (0%)
Query: 2 FRRVACAASSVNAGALTPRFV--STTRPSLGRIKVSGTVVDMDGDEMTRIIWALIKEKLI 59
R A + A T + RIKV+ VV+MDGDEMTRIIWA IKEKLI
Sbjct: 12 LSRAAGLSRCTPPAACTALGPPGQRRHYADRRIKVANPVVEMDGDEMTRIIWAFIKEKLI 71
Query: 60 LPHVDVPIEYYDLSITSRDASNDKVTEQAAEAIQRHNVGIKCATITPDEARVKEFNLKKM 119
LP+VDV ++Y+DL + RD ++D+VT +A A ++++V +KCATITPDEARV+EF LKKM
Sbjct: 72 LPNVDVQLKYFDLGLPHRDKTDDQVTIDSALATKKYSVAVKCATITPDEARVEEFKLKKM 131
Query: 120 WKSPNGTIRNILGGTVFREPIIVKNVPRVVPQWSEPIIVGRHAYGDQYKATESLF-PPGR 178
WKSPNGTIRNILGGTVFREPII KN+PR+VP W++PI +GRHA+GDQYKAT+ + G
Sbjct: 132 WKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTQPITIGRHAHGDQYKATDFVVNKSGT 191
Query: 179 LELVHTPANGGSPQVLEVFNFKGEGVGLAMYNTRESVEAFAESCFEYAIMRRYPLVLSTK 238
++V TP +G + EVFNF G GVG+ MYNT ES+ FA SCF+YAI +++PL +STK
Sbjct: 192 FKMVFTPKDGSGVKEWEVFNFPGGGVGMGMYNTDESISGFAHSCFQYAIQKKWPLYMSTK 251
Query: 239 NTILKKYDGLFLETFQRMYDTKYREQFERLNLTYVHRLIDDQVAQMIKGNGGFVWACKNY 298
NTILK YDG F + FQ ++D Y+ +F++L + Y HRLIDD VAQ++K +GGFVWACKNY
Sbjct: 252 NTILKAYDGRFKDIFQEIFDKHYKTEFDKLKIWYEHRLIDDMVAQVLKSSGGFVWACKNY 311
Query: 299 DGDVQSDIVAQGFGSLGLMTSVLLCPDGKTIESEAAHGTVTRHYREHQKGKETSTNSVAS 358
DGDVQSDI+AQGFGSLGLMTSVL+CPDGKTIE+EAAHGTVTRHYREHQKG+ TSTN +AS
Sbjct: 312 DGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIAS 371
Query: 359 IFAWTRGLAHRGKLDGNAPLVEFASSLERATIKTIEGGHMTKDLALCVHGAAALQ-RSHY 417
IFAWTRGL HRGKLD N L++FA +LE+ ++T+E G MTKDLA C+HG A ++ H+
Sbjct: 372 IFAWTRGLEHRGKLDSNPELIKFAQTLEKVCVETVESGTMTKDLAGCIHGLANVKLNEHF 431
Query: 418 ETTEVFIDSVAEELARSV 435
T F+D++ L +++
Sbjct: 432 VNTTDFLDAIKNTLDKAL 449
>sp|Q04467|IDHP_BOVIN Isocitrate dehydrogenase [NADP], mitochondrial precursor
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) (IDP) (ICD-M)
gb|AAI02510.1| Isocitrate dehydrogenase 2 (NADP+), mitochondrial [Bos taurus]
Length = 452
Score = 734 bits (1895), Expect = 0.0, Method: Composition-based stats.
Identities = 266/442 (60%), Positives = 338/442 (76%), Gaps = 11/442 (2%)
Query: 4 RVACAASSVNAGALTPRFVS--------TTRPSLGRIKVSGTVVDMDGDEMTRIIWALIK 55
R C AS + A P ++ + RIKV+ VV+MDGDEMTRIIW IK
Sbjct: 9 RSLCRASG-SGSAWAPAALTAPNLQEQPRRHYADKRIKVAKPVVEMDGDEMTRIIWQFIK 67
Query: 56 EKLILPHVDVPIEYYDLSITSRDASNDKVTEQAAEAIQRHNVGIKCATITPDEARVKEFN 115
EKLILPHVDV ++Y+DL + +RD +ND+VT +A A Q+++V +KCATITPDEARV+EF
Sbjct: 68 EKLILPHVDVQLKYFDLGLPNRDQTNDQVTIDSALATQKYSVAVKCATITPDEARVEEFK 127
Query: 116 LKKMWKSPNGTIRNILGGTVFREPIIVKNVPRVVPQWSEPIIVGRHAYGDQYKATESLFP 175
LKKMWKSPNGTIRNILGGTVFREPII KN+PR+VP W++PI +GRHA+GDQYKAT+ +
Sbjct: 128 LKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYKATDFVVD 187
Query: 176 -PGRLELVHTPANGGSPQVLEVFNFKGEGVGLAMYNTRESVEAFAESCFEYAIMRRYPLV 234
G ++V TP +G P+ EV+NF GVG+ MYNT ES+ FA SCF+YAI +++PL
Sbjct: 188 RAGTFKVVFTPKDGSGPKEWEVYNFPAGGVGMGMYNTDESISGFAHSCFQYAIQKKWPLY 247
Query: 235 LSTKNTILKKYDGLFLETFQRMYDTKYREQFERLNLTYVHRLIDDQVAQMIKGNGGFVWA 294
+STKNTILK YDG F + FQ +++ Y+ +F++ + Y HRLIDD VAQ++K +GGFVWA
Sbjct: 248 MSTKNTILKAYDGRFKDIFQAIFEKHYKTEFDKHKIWYEHRLIDDMVAQVLKSSGGFVWA 307
Query: 295 CKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDGKTIESEAAHGTVTRHYREHQKGKETSTN 354
CKNYDGDVQSDI+AQGFGSLGLMTSVL+CPDGKTIE+EAAHGTVTRHYREHQKG+ TSTN
Sbjct: 308 CKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTN 367
Query: 355 SVASIFAWTRGLAHRGKLDGNAPLVEFASSLERATIKTIEGGHMTKDLALCVHGAAALQ- 413
+ASIFAWTRGL HRGKLDGN L+ FA +LE+ ++T+E G MTKDLA C+HG + ++
Sbjct: 368 PIASIFAWTRGLEHRGKLDGNQDLIRFAQTLEKVCVETVESGAMTKDLAGCIHGLSNVKL 427
Query: 414 RSHYETTEVFIDSVAEELARSV 435
H+ T F+D++ L R++
Sbjct: 428 NEHFLNTSDFLDTIKSNLDRAL 449
>ref|XP_536192.2| PREDICTED: similar to isocitrate dehydrogenase 2 (NADP+),
mitochondrial [Canis familiaris]
Length = 517
Score = 731 bits (1889), Expect = 0.0, Method: Composition-based stats.
Identities = 257/410 (62%), Positives = 328/410 (80%), Gaps = 2/410 (0%)
Query: 28 SLGRIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQ 87
+ RIKV+ VV+MDGDEMTRIIW IKEKLILPHVDV ++Y+DL + +RD +ND+VT
Sbjct: 106 ADKRIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDVQLKYFDLGLPNRDQTNDQVTID 165
Query: 88 AAEAIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPR 147
+A A Q+++V +KCATITPDEARV+EF LKKMWKSPNGTIRNILGGTVFREPII KN+PR
Sbjct: 166 SALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPR 225
Query: 148 VVPQWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNFKGEGVGL 206
+VP W++PI +GRHA+GDQYKAT+ + G +++ +P +G + EV+NF G GVG+
Sbjct: 226 LVPGWTKPITIGRHAHGDQYKATDFVVDRAGTFKIIFSPKDGSGAKEWEVYNFPGGGVGM 285
Query: 207 AMYNTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFE 266
MYNT ES+ FA SCF+YAI +++PL +STKNTILK YDG F + FQ +++ Y+ F+
Sbjct: 286 GMYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFEKHYKTDFD 345
Query: 267 RLNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDG 326
+ + Y HRLIDD VAQ++K +GGFVWACKNYDGDVQSDI+AQGFGSLGLMTSVL+CPDG
Sbjct: 346 KNKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDG 405
Query: 327 KTIESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLE 386
KTIE+EAAHGTVTRHYREHQKG+ TSTN +ASIFAWTRGL HRGKLDGN L+ FA +LE
Sbjct: 406 KTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQTLE 465
Query: 387 RATIKTIEGGHMTKDLALCVHGAAALQ-RSHYETTEVFIDSVAEELARSV 435
+ ++T+E G MTKDLA C+HG + ++ H+ T F+D++ L +++
Sbjct: 466 KVCVQTVESGAMTKDLAGCIHGLSNVKLNEHFLNTSDFLDTIKNNLDKAL 515
>gb|ACO14046.1| Isocitrate dehydrogenase, mitochondrial precursor [Esox lucius]
Length = 451
Score = 730 bits (1886), Expect = 0.0, Method: Composition-based stats.
Identities = 266/439 (60%), Positives = 335/439 (76%), Gaps = 4/439 (0%)
Query: 1 MFRRVACAASSVNAGALTPRFVSTTRPSLG--RIKVSGTVVDMDGDEMTRIIWALIKEKL 58
+ R A + S A S + + G RIKVS VV+MDGDEMTRIIW IKEKL
Sbjct: 11 LSRSAATFSKSPAVLAPVSTCPSLQQRNYGDKRIKVSQPVVEMDGDEMTRIIWEFIKEKL 70
Query: 59 ILPHVDVPIEYYDLSITSRDASNDKVTEQAAEAIQRHNVGIKCATITPDEARVKEFNLKK 118
IL +VDV ++YYDL + RD +ND+VT +A A Q+++V +KCATITPDEARV+EF LKK
Sbjct: 71 ILSNVDVELKYYDLGLPYRDQTNDQVTIDSALATQKYHVAVKCATITPDEARVEEFKLKK 130
Query: 119 MWKSPNGTIRNILGGTVFREPIIVKNVPRVVPQWSEPIIVGRHAYGDQYKATESLF-PPG 177
MWKSPNGTIRNILGGTVFREPII KN+PR+VP W++PI +GRHA+GDQY+AT+ + PG
Sbjct: 131 MWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTQPITIGRHAFGDQYRATDFVVNQPG 190
Query: 178 RLELVHTPANGGSPQVLEVFNFKGEGVGLAMYNTRESVEAFAESCFEYAIMRRYPLVLST 237
++V +P +G Q V+NF G G G+ MYNT ES+ FA SCF+YAI +++PL LST
Sbjct: 191 TFKMVFSPTDGSKGQEWGVYNFPGGGCGMGMYNTDESISGFAHSCFQYAIGKKWPLYLST 250
Query: 238 KNTILKKYDGLFLETFQRMYDTKYREQFERLNLTYVHRLIDDQVAQMIKGNGGFVWACKN 297
KNTILK YDG F + F+ ++ Y+ +F++L + Y HRLIDD VAQ++K +G FVWACKN
Sbjct: 251 KNTILKAYDGRFKDIFEEIFQANYKPEFDKLKIWYEHRLIDDMVAQVLKSDGAFVWACKN 310
Query: 298 YDGDVQSDIVAQGFGSLGLMTSVLLCPDGKTIESEAAHGTVTRHYREHQKGKETSTNSVA 357
YDGDVQSDI+AQGFGSLGLMTSVL+CPDGKTIE+EAAHGTVTRHYREHQKG TSTN +A
Sbjct: 311 YDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGNPTSTNPIA 370
Query: 358 SIFAWTRGLAHRGKLDGNAPLVEFASSLERATIKTIEGGHMTKDLALCVHGAAALQ-RSH 416
SIFAWTRGL HRGKLDGN L++FA +LER ++T+E G MTKDLA C+HG + + H
Sbjct: 371 SIFAWTRGLEHRGKLDGNPDLIKFALTLERVCVETVESGVMTKDLAGCIHGLSKCKLNEH 430
Query: 417 YETTEVFIDSVAEELARSV 435
Y TE F+D++ + L +++
Sbjct: 431 YVNTEDFLDAIKKNLDKAL 449
>ref|XP_510589.2| PREDICTED: isocitrate dehydrogenase 2 (NADP+), mitochondrial
isoform 4 [Pan troglodytes]
Length = 452
Score = 729 bits (1884), Expect = 0.0, Method: Composition-based stats.
Identities = 264/442 (59%), Positives = 336/442 (76%), Gaps = 11/442 (2%)
Query: 4 RVACAASSVNAGALTPRFVSTTRP--------SLGRIKVSGTVVDMDGDEMTRIIWALIK 55
R C AS + A P ++ + RIKV+ VV+MDGDEMTRIIW IK
Sbjct: 9 RSLCRASG-SRPAWAPAALTAPTSQEQPRRHYADKRIKVAKPVVEMDGDEMTRIIWQFIK 67
Query: 56 EKLILPHVDVPIEYYDLSITSRDASNDKVTEQAAEAIQRHNVGIKCATITPDEARVKEFN 115
EKLILPHVD+ ++Y+DL + +RD ++D+VT +A A Q+++V +KCATITPDEARV+EF
Sbjct: 68 EKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDEARVEEFK 127
Query: 116 LKKMWKSPNGTIRNILGGTVFREPIIVKNVPRVVPQWSEPIIVGRHAYGDQYKATESLFP 175
LKKMWKSPNGTIRNILGGTVFREPII KN+PR+VP W++PI +GRHA+GDQYKAT+ +
Sbjct: 128 LKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYKATDFVAD 187
Query: 176 -PGRLELVHTPANGGSPQVLEVFNFKGEGVGLAMYNTRESVEAFAESCFEYAIMRRYPLV 234
G ++V TP +G + EV+NF GVG+ MYNT ES+ FA SCF+YAI +++PL
Sbjct: 188 RAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMYNTDESISGFAHSCFQYAIQKKWPLY 247
Query: 235 LSTKNTILKKYDGLFLETFQRMYDTKYREQFERLNLTYVHRLIDDQVAQMIKGNGGFVWA 294
+STKNTILK YDG F + FQ ++D Y+ F++ + Y HRLIDD VAQ++K +GGFVWA
Sbjct: 248 MSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKSSGGFVWA 307
Query: 295 CKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDGKTIESEAAHGTVTRHYREHQKGKETSTN 354
CKNYDGDVQSDI+AQGFGSLGLMTSVL+CPDGKTIE+EAAHGTVTRHYREHQKG+ TSTN
Sbjct: 308 CKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTN 367
Query: 355 SVASIFAWTRGLAHRGKLDGNAPLVEFASSLERATIKTIEGGHMTKDLALCVHGAAALQ- 413
+ASIFAWTRGL HRGKLDGN L+ FA +LE+ ++T+E G MTKDLA C+HG + ++
Sbjct: 368 PIASIFAWTRGLEHRGKLDGNQDLIRFAQTLEKVCVETVESGAMTKDLAGCIHGLSNVKL 427
Query: 414 RSHYETTEVFIDSVAEELARSV 435
H+ T F+D++ L R++
Sbjct: 428 NEHFLNTTDFLDTIKSNLDRAL 449
>sp|P54071|IDHP_MOUSE Isocitrate dehydrogenase [NADP], mitochondrial precursor
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) (IDP) (ICD-M)
dbj|BAC40149.1| unnamed protein product [Mus musculus]
gb|AAH60030.1| Isocitrate dehydrogenase 2 (NADP+), mitochondrial [Mus musculus]
dbj|BAE41142.1| unnamed protein product [Mus musculus]
dbj|BAE36505.1| unnamed protein product [Mus musculus]
dbj|BAE26628.1| unnamed protein product [Mus musculus]
gb|EDL07035.1| isocitrate dehydrogenase 2 (NADP+), mitochondrial, isoform CRA_d
[Mus musculus]
Length = 452
Score = 729 bits (1883), Expect = 0.0, Method: Composition-based stats.
Identities = 262/414 (63%), Positives = 327/414 (78%), Gaps = 2/414 (0%)
Query: 24 TTRPSLGRIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDK 83
+ RIKV VV+MDGDEMTRIIW IKEKLILPHVDV ++Y+DL + +RD +ND+
Sbjct: 36 RRHYAEKRIKVEKPVVEMDGDEMTRIIWQFIKEKLILPHVDVQLKYFDLGLPNRDQTNDQ 95
Query: 84 VTEQAAEAIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVK 143
VT +A A Q+++V +KCATITPDEARV+EF LKKMWKSPNGTIRNILGGTVFREPII K
Sbjct: 96 VTIDSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICK 155
Query: 144 NVPRVVPQWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNFKGE 202
N+PR+VP W++PI +GRHA+GDQYKAT+ + G +LV TP +G S + EV+NF
Sbjct: 156 NIPRLVPGWTKPITIGRHAHGDQYKATDFVVDRAGTFKLVFTPKDGSSAKEWEVYNFPAG 215
Query: 203 GVGLAMYNTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYR 262
GVG+ MYNT ES+ FA SCF+Y+I +++PL LSTKNTILK YDG F + FQ ++D Y+
Sbjct: 216 GVGMGMYNTDESISGFAHSCFQYSIQKKWPLYLSTKNTILKAYDGRFKDIFQEIFDKHYK 275
Query: 263 EQFERLNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLL 322
F++ + Y HRLIDD VAQ++K +GGFVWACKNYDGDVQSDI+AQGFGSLGLMTSVL+
Sbjct: 276 TDFDKNKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLV 335
Query: 323 CPDGKTIESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFA 382
CPDGKTIE+EAAHGTVTRHYREHQKG+ TSTN +ASIFAWTRGL HRGKLDGN L+ FA
Sbjct: 336 CPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFA 395
Query: 383 SSLERATIKTIEGGHMTKDLALCVHGAAALQ-RSHYETTEVFIDSVAEELARSV 435
+LE+ ++T+E G MTKDLA C+HG + ++ H+ T F+D++ L R++
Sbjct: 396 QTLEKVCVQTVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRAL 449
>ref|XP_001095686.1| PREDICTED: isocitrate dehydrogenase 2 (NADP+), mitochondrial
[Macaca mulatta]
sp|Q4R502|IDHP_MACFA Isocitrate dehydrogenase [NADP], mitochondrial precursor
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) (IDP) (ICD-M)
dbj|BAE01823.1| unnamed protein product [Macaca fascicularis]
Length = 452
Score = 729 bits (1882), Expect = 0.0, Method: Composition-based stats.
Identities = 264/442 (59%), Positives = 336/442 (76%), Gaps = 11/442 (2%)
Query: 4 RVACAASSVNAGALTPRFVSTTRP--------SLGRIKVSGTVVDMDGDEMTRIIWALIK 55
R C AS + A P ++ + RIKV+ VV+MDGDEMTRIIW IK
Sbjct: 9 RSLCRASG-SRPAWAPAALTAPTSQEQTRRHYADKRIKVAKPVVEMDGDEMTRIIWQFIK 67
Query: 56 EKLILPHVDVPIEYYDLSITSRDASNDKVTEQAAEAIQRHNVGIKCATITPDEARVKEFN 115
EKLILPHVD+ ++Y+DL + +RD ++D+VT +A A Q+++V +KCATITPDEARV+EF
Sbjct: 68 EKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDEARVEEFK 127
Query: 116 LKKMWKSPNGTIRNILGGTVFREPIIVKNVPRVVPQWSEPIIVGRHAYGDQYKATESLFP 175
LKKMWKSPNGTIRNILGGTVFREPII KN+PR+VP W++PI +GRHA+GDQYKAT+ +
Sbjct: 128 LKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYKATDFVAD 187
Query: 176 -PGRLELVHTPANGGSPQVLEVFNFKGEGVGLAMYNTRESVEAFAESCFEYAIMRRYPLV 234
G ++V TP +G + EV+NF GVG+ MYNT ES+ FA SCF+YAI +++PL
Sbjct: 188 RAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMYNTDESISGFAHSCFQYAIQKKWPLY 247
Query: 235 LSTKNTILKKYDGLFLETFQRMYDTKYREQFERLNLTYVHRLIDDQVAQMIKGNGGFVWA 294
+STKNTILK YDG F + FQ ++D Y+ F++ + Y HRLIDD VAQ++K +GGFVWA
Sbjct: 248 MSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKSSGGFVWA 307
Query: 295 CKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDGKTIESEAAHGTVTRHYREHQKGKETSTN 354
CKNYDGDVQSDI+AQGFGSLGLMTSVL+CPDGKTIE+EAAHGTVTRHYREHQKG+ TSTN
Sbjct: 308 CKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTN 367
Query: 355 SVASIFAWTRGLAHRGKLDGNAPLVEFASSLERATIKTIEGGHMTKDLALCVHGAAALQ- 413
+ASIFAWTRGL HRGKLDGN L+ FA +LE+ ++T+E G MTKDLA C+HG + ++
Sbjct: 368 PIASIFAWTRGLEHRGKLDGNQDLIRFAQTLEKVCVETVESGAMTKDLAGCIHGLSNVKL 427
Query: 414 RSHYETTEVFIDSVAEELARSV 435
H+ T F+D++ L R++
Sbjct: 428 NEHFLNTTDFLDTIKSNLDRAL 449
>ref|NP_002159.2| isocitrate dehydrogenase 2 (NADP+), mitochondrial precursor [Homo
sapiens]
sp|P48735|IDHP_HUMAN Isocitrate dehydrogenase [NADP], mitochondrial precursor
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) (IDP) (ICD-M)
gb|AAH09244.1| Isocitrate dehydrogenase 2 (NADP+), mitochondrial [Homo sapiens]
gb|AAH71828.1| Isocitrate dehydrogenase 2 (NADP+), mitochondrial [Homo sapiens]
gb|EAX02082.1| isocitrate dehydrogenase 2 (NADP+), mitochondrial, isoform CRA_a
[Homo sapiens]
gb|ABM83743.1| isocitrate dehydrogenase 2 (NADP+), mitochondrial [synthetic
construct]
gb|ABM87062.1| isocitrate dehydrogenase 2 (NADP+), mitochondrial [synthetic
construct]
Length = 452
Score = 729 bits (1882), Expect = 0.0, Method: Composition-based stats.
Identities = 264/442 (59%), Positives = 335/442 (75%), Gaps = 11/442 (2%)
Query: 4 RVACAASSVNAGALTPRFVSTTRP--------SLGRIKVSGTVVDMDGDEMTRIIWALIK 55
R C AS + A P ++ + RIKV+ VV+MDGDEMTRIIW IK
Sbjct: 9 RSLCRASG-SRPAWAPAALTAPTSQEQPRRHYADKRIKVAKPVVEMDGDEMTRIIWQFIK 67
Query: 56 EKLILPHVDVPIEYYDLSITSRDASNDKVTEQAAEAIQRHNVGIKCATITPDEARVKEFN 115
EKLILPHVD+ ++Y+DL + +RD ++D+VT +A A Q+++V +KCATITPDEARV+EF
Sbjct: 68 EKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDEARVEEFK 127
Query: 116 LKKMWKSPNGTIRNILGGTVFREPIIVKNVPRVVPQWSEPIIVGRHAYGDQYKATESLFP 175
LKKMWKSPNGTIRNILGGTVFREPII KN+PR+VP W++PI +GRHA+GDQYKAT+ +
Sbjct: 128 LKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYKATDFVAD 187
Query: 176 -PGRLELVHTPANGGSPQVLEVFNFKGEGVGLAMYNTRESVEAFAESCFEYAIMRRYPLV 234
G ++V TP +G + EV+NF GVG+ MYNT ES+ FA SCF+YAI +++PL
Sbjct: 188 RAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMYNTDESISGFAHSCFQYAIQKKWPLY 247
Query: 235 LSTKNTILKKYDGLFLETFQRMYDTKYREQFERLNLTYVHRLIDDQVAQMIKGNGGFVWA 294
+STKNTILK YDG F + FQ ++D Y+ F++ + Y HRLIDD VAQ++K +GGFVWA
Sbjct: 248 MSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKSSGGFVWA 307
Query: 295 CKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDGKTIESEAAHGTVTRHYREHQKGKETSTN 354
CKNYDGDVQSDI+AQGFGSLGLMTSVL+CPDGKTIE+EAAHGTVTRHYREHQKG+ TSTN
Sbjct: 308 CKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTN 367
Query: 355 SVASIFAWTRGLAHRGKLDGNAPLVEFASSLERATIKTIEGGHMTKDLALCVHGAAALQ- 413
+ASIFAWTRGL HRGKLDGN L+ FA LE+ ++T+E G MTKDLA C+HG + ++
Sbjct: 368 PIASIFAWTRGLEHRGKLDGNQDLIRFAQMLEKVCVETVESGAMTKDLAGCIHGLSNVKL 427
Query: 414 RSHYETTEVFIDSVAEELARSV 435
H+ T F+D++ L R++
Sbjct: 428 NEHFLNTTDFLDTIKSNLDRAL 449
>ref|XP_001369305.1| PREDICTED: hypothetical protein [Monodelphis domestica]
Length = 455
Score = 728 bits (1881), Expect = 0.0, Method: Composition-based stats.
Identities = 260/414 (62%), Positives = 325/414 (78%), Gaps = 2/414 (0%)
Query: 24 TTRPSLGRIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDK 83
+ RIKV VV+MDGDEMTRIIW IKEKLILPHVDV ++Y+DL + RD ++D+
Sbjct: 39 RRNYAHKRIKVDKPVVEMDGDEMTRIIWQFIKEKLILPHVDVQLKYFDLGLPHRDQTDDQ 98
Query: 84 VTEQAAEAIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVK 143
VT +A A Q+++V +KCATITPDEARV+EF LKKMWKSPNGTIRNILGGTVFREPII K
Sbjct: 99 VTIDSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICK 158
Query: 144 NVPRVVPQWSEPIIVGRHAYGDQYKATESLF-PPGRLELVHTPANGGSPQVLEVFNFKGE 202
N+PR+VP W+ PI +GRHA+GDQYKAT+ + G ++V TP +G + EV+NF
Sbjct: 159 NIPRLVPGWTRPITIGRHAHGDQYKATDFVVDKAGTFKMVFTPKDGSGAKEWEVYNFPAG 218
Query: 203 GVGLAMYNTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYR 262
GVG+ MYNT ES+ FA SCF+YAI +++PL +STKNTILK YDG F + FQ ++D Y+
Sbjct: 219 GVGMGMYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYK 278
Query: 263 EQFERLNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLL 322
F++ + Y HRLIDD VAQ++K NGGFVWACKNYDGDVQSDI+AQGFGSLGLMTSVL+
Sbjct: 279 TDFDKNKIWYEHRLIDDMVAQVLKSNGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLV 338
Query: 323 CPDGKTIESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFA 382
CPDGKTIE+EAAHGTVTRHYREHQKG+ TSTN +ASIFAWTRGL HRGKLDGN L++FA
Sbjct: 339 CPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIKFA 398
Query: 383 SSLERATIKTIEGGHMTKDLALCVHGAAALQ-RSHYETTEVFIDSVAEELARSV 435
+LE+ ++T+E G MTKDLA C+HG + ++ HY T F+D++ L +++
Sbjct: 399 QTLEKVCVQTVESGAMTKDLAGCIHGLSNVKLNEHYLNTGDFLDTIKNNLDKAL 452
>sp|P33198|IDHP_PIG Isocitrate dehydrogenase [NADP], mitochondrial precursor
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) (IDP) (ICD-M)
gb|AAA31089.1| NADPH-specific isocitrate dehydrogenase
Length = 421
Score = 728 bits (1880), Expect = 0.0, Method: Composition-based stats.
Identities = 260/416 (62%), Positives = 329/416 (79%), Gaps = 2/416 (0%)
Query: 22 VSTTRPSLGRIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASN 81
+ + RIKV+ VV+MDGDEMTRIIW IKEKLILPHVDV ++Y+DL + +RD +N
Sbjct: 3 AAARHYADQRIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDVQLKYFDLGLPNRDQTN 62
Query: 82 DKVTEQAAEAIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPII 141
D+VT +A A Q+++V +KCATITPDEARV+EF LKKMWKSPNGTIRNILGGTVFREPII
Sbjct: 63 DQVTIDSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPII 122
Query: 142 VKNVPRVVPQWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNFK 200
KN+PR+VP W++PI +GRHA+GDQYKAT+ + G ++V TP +G S + EV+NF
Sbjct: 123 CKNIPRLVPGWTKPITIGRHAHGDQYKATDFVVDRAGTFKIVFTPKDGSSAKQWEVYNFP 182
Query: 201 GEGVGLAMYNTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTK 260
GVG+ MYNT ES+ FA SCF+YAI +++PL +STKNTILK YDG F + FQ +++
Sbjct: 183 AGGVGMGMYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFEKH 242
Query: 261 YREQFERLNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSV 320
Y+ F++ + Y HRLIDD VAQ++K +GGFVWACKNYDGDVQSDI+AQGFGSLGLMTSV
Sbjct: 243 YKTDFDKYKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSV 302
Query: 321 LLCPDGKTIESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVE 380
L+CPDGKTIE+EAAHGTVTRHYREHQKG+ TSTN +ASIFAWTRGL HRGKLDGN L+
Sbjct: 303 LVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIR 362
Query: 381 FASSLERATIKTIEGGHMTKDLALCVHGAAALQ-RSHYETTEVFIDSVAEELARSV 435
FA +LE+ ++T+E G MTKDLA C+HG + ++ H+ T F+D++ L R++
Sbjct: 363 FAQTLEKVCVETVESGAMTKDLAGCIHGLSNVKLNEHFLNTSDFLDTIKSNLDRAL 418
>emb|CAA49208.1| isocitrate dehydrogenase (NADP+) [Homo sapiens]
Length = 452
Score = 728 bits (1880), Expect = 0.0, Method: Composition-based stats.
Identities = 260/433 (60%), Positives = 331/433 (76%), Gaps = 7/433 (1%)
Query: 5 VACAASSVNAGALTPRFVSTTRPSLGRIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVD 64
A ++ + R + RIKV+ VV+MDGDEMTRIIW IKEKLILPHVD
Sbjct: 22 APAALTAPTSQEHPRRHYADK-----RIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVD 76
Query: 65 VPIEYYDLSITSRDASNDKVTEQAAEAIQRHNVGIKCATITPDEARVKEFNLKKMWKSPN 124
+ ++Y+DL + +RD ++D+VT +A A Q+++V +KCATITPDEARV+EF LKKMWKSPN
Sbjct: 77 IQLKYFDLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPN 136
Query: 125 GTIRNILGGTVFREPIIVKNVPRVVPQWSEPIIVGRHAYGDQYKATESLFP-PGRLELVH 183
GTIRNILGGTVFREPII KN+PR+VP W++PI +GRHA+GDQYKAT+ + G ++V
Sbjct: 137 GTIRNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYKATDFVADRAGTFKMVF 196
Query: 184 TPANGGSPQVLEVFNFKGEGVGLAMYNTRESVEAFAESCFEYAIMRRYPLVLSTKNTILK 243
TP +G + EV+NF GVG+ MYNT ES+ FA SCF+YAI +++PL +STKNTILK
Sbjct: 197 TPKDGSGVKEWEVYNFPAGGVGMGMYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILK 256
Query: 244 KYDGLFLETFQRMYDTKYREQFERLNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQ 303
YDG F + FQ ++D Y+ F++ + Y HRLIDD VAQ++K +GGFVWACKNYDGDVQ
Sbjct: 257 AYDGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQ 316
Query: 304 SDIVAQGFGSLGLMTSVLLCPDGKTIESEAAHGTVTRHYREHQKGKETSTNSVASIFAWT 363
SDI+AQGFGSLGLMTSVL+CPDGKTIE+EAAHGTVTRHYREHQKG+ TSTN +ASIFAWT
Sbjct: 317 SDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWT 376
Query: 364 RGLAHRGKLDGNAPLVEFASSLERATIKTIEGGHMTKDLALCVHGAAALQ-RSHYETTEV 422
RGL HRGKLDGN L+ FA LE+ ++T+E G MTKDLA C+HG + ++ H+ T
Sbjct: 377 RGLEHRGKLDGNQDLIRFAQMLEKVCVETVESGAMTKDLAGCIHGLSNVKLNEHFLNTMD 436
Query: 423 FIDSVAEELARSV 435
F+D++ L R++
Sbjct: 437 FLDTIKSNLDRAL 449
>ref|NP_766599.1| isocitrate dehydrogenase 2 (NADP+), mitochondrial [Mus musculus]
gb|AAG43538.1|AF212319_1 NADP+-specific isocitrate dehydrogenase [Mus musculus]
Length = 452
Score = 728 bits (1880), Expect = 0.0, Method: Composition-based stats.
Identities = 263/414 (63%), Positives = 327/414 (78%), Gaps = 2/414 (0%)
Query: 24 TTRPSLGRIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDK 83
+ RIKV VV+MDGDEMTRIIW IKEKLILPHVDV ++Y+DL + +RD +ND+
Sbjct: 36 RRHYAEKRIKVEKPVVEMDGDEMTRIIWQFIKEKLILPHVDVQLKYFDLGLPNRDQTNDQ 95
Query: 84 VTEQAAEAIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVK 143
VT +A A Q+++V +KCATITPDEARV+EF LKKMWKSPNGTIRNILGGTVFREPII K
Sbjct: 96 VTIDSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICK 155
Query: 144 NVPRVVPQWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNFKGE 202
N+PR+VP W++PI +GRHA+GDQYKAT+ + G +LV TP +G S + EV+NF
Sbjct: 156 NIPRLVPGWTKPITIGRHAHGDQYKATDFVVDRAGTFKLVFTPKDGSSAKEWEVYNFPAG 215
Query: 203 GVGLAMYNTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYR 262
GVG+ MYNT ES+ FA SCF+Y+I +++PL LSTKNTILK YDG F + FQ ++D Y+
Sbjct: 216 GVGMGMYNTDESISGFAHSCFQYSIQKKWPLYLSTKNTILKAYDGRFKDIFQEIFDKHYK 275
Query: 263 EQFERLNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLL 322
F+R + Y HRLIDD VAQ++K +GGFVWACKNYDGDVQSDI+AQGFGSLGLMTSVL+
Sbjct: 276 TDFDRNKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLV 335
Query: 323 CPDGKTIESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFA 382
CPDGKTIE+EAAHGTVTRHYREHQKG+ TSTN +ASIFAWTRGL HRGKLDGN L+ FA
Sbjct: 336 CPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFA 395
Query: 383 SSLERATIKTIEGGHMTKDLALCVHGAAALQ-RSHYETTEVFIDSVAEELARSV 435
+LE+ ++T+E G MTKDLA C+HG + ++ H+ T F+D++ L R++
Sbjct: 396 QTLEKVCVQTVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRAL 449
>ref|NP_001014183.1| isocitrate dehydrogenase 2 (NADP+), mitochondrial [Rattus
norvegicus]
sp|P56574|IDHP_RAT Isocitrate dehydrogenase [NADP], mitochondrial precursor
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) (IDP) (ICD-M)
gb|AAH76398.1| Similar to NADP+-specific isocitrate dehydrogenase [Rattus
norvegicus]
gb|EDM08608.1| similar to NADP+-specific isocitrate dehydrogenase, isoform CRA_b
[Rattus norvegicus]
Length = 452
Score = 727 bits (1878), Expect = 0.0, Method: Composition-based stats.
Identities = 260/414 (62%), Positives = 326/414 (78%), Gaps = 2/414 (0%)
Query: 24 TTRPSLGRIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDK 83
+ RIKV VV+MDGDEMTRIIW IKEKLILPHVDV ++Y+DL + +RD +ND+
Sbjct: 36 RRHYAEKRIKVEKPVVEMDGDEMTRIIWQFIKEKLILPHVDVQLKYFDLGLPNRDQTNDQ 95
Query: 84 VTEQAAEAIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVK 143
VT +A A Q+++V +KCATITPDEARV+EF LKKMWKSPNGTIRNILGGTVFREPII K
Sbjct: 96 VTIDSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICK 155
Query: 144 NVPRVVPQWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNFKGE 202
N+PR+VP W++PI +GRHA+GDQYKAT+ + G +LV TP +G + EV+NF
Sbjct: 156 NIPRLVPGWTKPITIGRHAHGDQYKATDFVVDRAGMFKLVFTPKDGSGAKEWEVYNFPAG 215
Query: 203 GVGLAMYNTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYR 262
GVG+ MYNT ES+ FA SCF+Y+I +++PL LSTKNTI+K YDG F + FQ ++D Y+
Sbjct: 216 GVGMGMYNTDESISGFAHSCFQYSIQKKWPLYLSTKNTIMKAYDGRFKDIFQEIFDKHYK 275
Query: 263 EQFERLNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLL 322
F++ + Y HRLIDD VAQ++K +GGFVWACKNYDGDVQSDI+AQGFGSLGLMTSVL+
Sbjct: 276 TDFDKNKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLV 335
Query: 323 CPDGKTIESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFA 382
CPDGKTIE+EAAHGTVTRHYREHQKG+ TSTN +ASIFAWTRGL HRGKLDGN L+ FA
Sbjct: 336 CPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFA 395
Query: 383 SSLERATIKTIEGGHMTKDLALCVHGAAALQ-RSHYETTEVFIDSVAEELARSV 435
+LE+ ++T+E G MTKDLA C+HG + ++ H+ T F+D++ L R++
Sbjct: 396 QTLEKVCVQTVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRAL 449
>pdb|1LWD|A Chain A, Crystal Structure Of Nadp-Dependent Isocitrate
Dehydrogenase From Porcine Heart Mitochondria
pdb|1LWD|B Chain B, Crystal Structure Of Nadp-Dependent Isocitrate
Dehydrogenase From Porcine Heart Mitochondria
Length = 413
Score = 727 bits (1878), Expect = 0.0, Method: Composition-based stats.
Identities = 260/410 (63%), Positives = 328/410 (80%), Gaps = 2/410 (0%)
Query: 28 SLGRIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQ 87
+ RIKV+ VV+MDGDEMTRIIW IKEKLILPHVDV ++Y+DL + +RD +ND+VT
Sbjct: 1 ADQRIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDVQLKYFDLGLPNRDQTNDQVTID 60
Query: 88 AAEAIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPR 147
+A A Q+++V +KCATITPDEARV+EF LKKMWKSPNGTIRNILGGTVFREPII KN+PR
Sbjct: 61 SALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPR 120
Query: 148 VVPQWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNFKGEGVGL 206
+VP W++PI +GRHA+GDQYKAT+ + G ++V TP +G S + EV+NF GVG+
Sbjct: 121 LVPGWTKPITIGRHAHGDQYKATDFVVDRAGTFKIVFTPKDGSSAKQWEVYNFPAGGVGM 180
Query: 207 AMYNTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFE 266
MYNT ES+ FA SCF+YAI +++PL +STKNTILK YDG F + FQ +++ Y+ F+
Sbjct: 181 GMYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFEKHYKTDFD 240
Query: 267 RLNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDG 326
+ + Y HRLIDD VAQ++K +GGFVWACKNYDGDVQSDI+AQGFGSLGLMTSVL+CPDG
Sbjct: 241 KYKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDG 300
Query: 327 KTIESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLE 386
KTIE+EAAHGTVTRHYREHQKG+ TSTN +ASIFAWTRGL HRGKLDGN L+ FA +LE
Sbjct: 301 KTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQTLE 360
Query: 387 RATIKTIEGGHMTKDLALCVHGAAALQ-RSHYETTEVFIDSVAEELARSV 435
+ ++T+E G MTKDLA C+HG + ++ H+ T F+D++ L R++
Sbjct: 361 KVCVETVESGAMTKDLAGCIHGLSNVKLNEHFLNTSDFLDTIKSNLDRAL 410
>dbj|BAD96636.1| isocitrate dehydrogenase 2 (NADP+), mitochondrial precursor variant
[Homo sapiens]
Length = 452
Score = 727 bits (1878), Expect = 0.0, Method: Composition-based stats.
Identities = 264/442 (59%), Positives = 334/442 (75%), Gaps = 11/442 (2%)
Query: 4 RVACAASSVNAGALTPRFVSTTRP--------SLGRIKVSGTVVDMDGDEMTRIIWALIK 55
R C AS + A P ++ + RIKV+ VV+MDGDEMTRIIW IK
Sbjct: 9 RSLCRASG-SRPAWAPAALTAPTSQEQPRRHYADKRIKVAKPVVEMDGDEMTRIIWQFIK 67
Query: 56 EKLILPHVDVPIEYYDLSITSRDASNDKVTEQAAEAIQRHNVGIKCATITPDEARVKEFN 115
EKLILPHVD+ ++Y+DL + +RD ++D+VT +A A Q+++V +KCATITPDEARV+EF
Sbjct: 68 EKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDEARVEEFK 127
Query: 116 LKKMWKSPNGTIRNILGGTVFREPIIVKNVPRVVPQWSEPIIVGRHAYGDQYKATESLFP 175
LKKMWKSPNGTIRNILGGTVFREPII KN+PR+VP W++PI +GRHA+GDQYKAT+ +
Sbjct: 128 LKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYKATDFVAD 187
Query: 176 -PGRLELVHTPANGGSPQVLEVFNFKGEGVGLAMYNTRESVEAFAESCFEYAIMRRYPLV 234
G ++V TP +G + EV+NF GVG+ MYNT ES+ FA SCF+YAI +++PL
Sbjct: 188 RAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMYNTDESISGFAHSCFQYAIQKKWPLY 247
Query: 235 LSTKNTILKKYDGLFLETFQRMYDTKYREQFERLNLTYVHRLIDDQVAQMIKGNGGFVWA 294
+STKNTILK YDG F + FQ ++D Y F++ + Y HRLIDD VAQ++K +GGFVWA
Sbjct: 248 MSTKNTILKAYDGRFKDIFQEIFDKHYETDFDKNKIWYEHRLIDDMVAQVLKSSGGFVWA 307
Query: 295 CKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDGKTIESEAAHGTVTRHYREHQKGKETSTN 354
CKNYDGDVQSDI+AQGFGSLGLMTSVL+CPDGKTIE+EAAHGTVTRHYREHQKG+ TSTN
Sbjct: 308 CKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTN 367
Query: 355 SVASIFAWTRGLAHRGKLDGNAPLVEFASSLERATIKTIEGGHMTKDLALCVHGAAALQ- 413
+ASIFAWTRGL HRGKLDGN L+ FA LE+ ++T+E G MTKDLA C+HG + ++
Sbjct: 368 PIASIFAWTRGLEHRGKLDGNQDLIRFAQMLEKVCVETVESGAMTKDLAGCIHGLSNVKL 427
Query: 414 RSHYETTEVFIDSVAEELARSV 435
H+ T F+D++ L R++
Sbjct: 428 NEHFLNTTDFLDTIKSNLDRAL 449
>gb|EAX02083.1| isocitrate dehydrogenase 2 (NADP+), mitochondrial, isoform CRA_b
[Homo sapiens]
Length = 422
Score = 725 bits (1872), Expect = 0.0, Method: Composition-based stats.
Identities = 261/418 (62%), Positives = 329/418 (78%), Gaps = 2/418 (0%)
Query: 20 RFVSTTRPSLGRIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDA 79
R VS + RIKV+ VV+MDGDEMTRIIW IKEKLILPHVD+ ++Y+DL + +RD
Sbjct: 2 RCVSLLLDADKRIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQ 61
Query: 80 SNDKVTEQAAEAIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREP 139
++D+VT +A A Q+++V +KCATITPDEARV+EF LKKMWKSPNGTIRNILGGTVFREP
Sbjct: 62 TDDQVTIDSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREP 121
Query: 140 IIVKNVPRVVPQWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFN 198
II KN+PR+VP W++PI +GRHA+GDQYKAT+ + G ++V TP +G + EV+N
Sbjct: 122 IICKNIPRLVPGWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYN 181
Query: 199 FKGEGVGLAMYNTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYD 258
F GVG+ MYNT ES+ FA SCF+YAI +++PL +STKNTILK YDG F + FQ ++D
Sbjct: 182 FPAGGVGMGMYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFD 241
Query: 259 TKYREQFERLNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMT 318
Y+ F++ + Y HRLIDD VAQ++K +GGFVWACKNYDGDVQSDI+AQGFGSLGLMT
Sbjct: 242 KHYKTDFDKNKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMT 301
Query: 319 SVLLCPDGKTIESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPL 378
SVL+CPDGKTIE+EAAHGTVTRHYREHQKG+ TSTN +ASIFAWTRGL HRGKLDGN L
Sbjct: 302 SVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDL 361
Query: 379 VEFASSLERATIKTIEGGHMTKDLALCVHGAAALQ-RSHYETTEVFIDSVAEELARSV 435
+ FA LE+ ++T+E G MTKDLA C+HG + ++ H+ T F+D++ L R++
Sbjct: 362 IRFAQMLEKVCVETVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRAL 419
>ref|XP_001168316.1| PREDICTED: isocitrate dehydrogenase 2 (NADP+), mitochondrial
isoform 3 [Pan troglodytes]
Length = 415
Score = 723 bits (1867), Expect = 0.0, Method: Composition-based stats.
Identities = 258/412 (62%), Positives = 327/412 (79%), Gaps = 2/412 (0%)
Query: 26 RPSLGRIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVT 85
+ RIKV+ VV+MDGDEMTRIIW IKEKLILPHVD+ ++Y+DL + +RD ++D+VT
Sbjct: 1 MNADKRIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVT 60
Query: 86 EQAAEAIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNV 145
+A A Q+++V +KCATITPDEARV+EF LKKMWKSPNGTIRNILGGTVFREPII KN+
Sbjct: 61 IDSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNI 120
Query: 146 PRVVPQWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNFKGEGV 204
PR+VP W++PI +GRHA+GDQYKAT+ + G ++V TP +G + EV+NF GV
Sbjct: 121 PRLVPGWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGV 180
Query: 205 GLAMYNTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQ 264
G+ MYNT ES+ FA SCF+YAI +++PL +STKNTILK YDG F + FQ ++D Y+
Sbjct: 181 GMGMYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTD 240
Query: 265 FERLNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCP 324
F++ + Y HRLIDD VAQ++K +GGFVWACKNYDGDVQSDI+AQGFGSLGLMTSVL+CP
Sbjct: 241 FDKNKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCP 300
Query: 325 DGKTIESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASS 384
DGKTIE+EAAHGTVTRHYREHQKG+ TSTN +ASIFAWTRGL HRGKLDGN L+ FA +
Sbjct: 301 DGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQT 360
Query: 385 LERATIKTIEGGHMTKDLALCVHGAAALQ-RSHYETTEVFIDSVAEELARSV 435
LE+ ++T+E G MTKDLA C+HG + ++ H+ T F+D++ L R++
Sbjct: 361 LEKVCVETVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRAL 412
>ref|NP_001080321.1| hypothetical protein LOC380013 [Xenopus laevis]
gb|AAH54241.1| MGC64442 protein [Xenopus laevis]
Length = 454
Score = 721 bits (1862), Expect = 0.0, Method: Composition-based stats.
Identities = 260/439 (59%), Positives = 330/439 (75%), Gaps = 7/439 (1%)
Query: 4 RVACAASSVNAGALTPRFVSTTR----PSLGRIKVSGTVVDMDGDEMTRIIWALIKEKLI 59
R + A N G L P + + RIKV+ VV+MDGDEMTRIIW IKEKLI
Sbjct: 13 RASATALGKNPGVLAPALSQQLQQQRNYADKRIKVANPVVEMDGDEMTRIIWEFIKEKLI 72
Query: 60 LPHVDVPIEYYDLSITSRDASNDKVTEQAAEAIQRHNVGIKCATITPDEARVKEFNLKKM 119
L +VDV ++Y+DL + RD ++D+VT +A A ++NV +KCATITPDEARV+EF LKKM
Sbjct: 73 LSNVDVELKYFDLGLPYRDQTDDQVTIDSALATLKYNVAVKCATITPDEARVEEFKLKKM 132
Query: 120 WKSPNGTIRNILGGTVFREPIIVKNVPRVVPQWSEPIIVGRHAYGDQYKATESLF-PPGR 178
WKSPNGT+RNILGGTVFREPII KN+PR+VP W++ I +GRHA+GDQYKAT+ + G
Sbjct: 133 WKSPNGTVRNILGGTVFREPIICKNIPRLVPGWTQAITIGRHAHGDQYKATDFVVDQAGT 192
Query: 179 LELVHTPANGGSPQVLEVFNFKGEGVGLAMYNTRESVEAFAESCFEYAIMRRYPLVLSTK 238
++V TPANG + + EVF F GVG+ MYNT ES+ FA SCF+YAI +++PL +STK
Sbjct: 193 FKMVFTPANGTATKEWEVFKFPAGGVGMGMYNTDESISGFAHSCFQYAIQKKWPLYMSTK 252
Query: 239 NTILKKYDGLFLETFQRMYDTKYREQFERLNLTYVHRLIDDQVAQMIKGNGGFVWACKNY 298
NTILK YDG F + FQ +++ Y+ F+++ + Y HRLIDD VAQ++K +GGFVWACKNY
Sbjct: 253 NTILKAYDGRFKDIFQDIFEKHYKPDFDKVKIWYEHRLIDDMVAQVLKSSGGFVWACKNY 312
Query: 299 DGDVQSDIVAQGFGSLGLMTSVLLCPDGKTIESEAAHGTVTRHYREHQKGKETSTNSVAS 358
DGDVQSDI+AQGFGSLGLM+SVL+CPDGKTIE+EAAHGTVTRHYREHQKG+ TSTN +AS
Sbjct: 313 DGDVQSDILAQGFGSLGLMSSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIAS 372
Query: 359 IFAWTRGLAHRGKLDGNAPLVEFASSLERATIKTIEGGHMTKDLALCVHG--AAALQRSH 416
IFAWTRGL HRGKLDGN L+ F+ LE+ ++T+E G MTKDLA C+HG + H
Sbjct: 373 IFAWTRGLEHRGKLDGNQDLINFSLKLEKVCVETVESGIMTKDLAGCIHGGMSNVRLNEH 432
Query: 417 YETTEVFIDSVAEELARSV 435
Y T F+D++ L +++
Sbjct: 433 YVNTTDFLDAIKNNLDKAL 451
>ref|XP_001168291.1| PREDICTED: isocitrate dehydrogenase 2 (NADP+), mitochondrial
isoform 2 [Pan troglodytes]
Length = 475
Score = 720 bits (1860), Expect = 0.0, Method: Composition-based stats.
Identities = 264/465 (56%), Positives = 336/465 (72%), Gaps = 34/465 (7%)
Query: 4 RVACAASSVNAGALTPRFVSTTRP--------SLGRIKVSGTVVDMDGDEMTRIIWALIK 55
R C AS + A P ++ + RIKV+ VV+MDGDEMTRIIW IK
Sbjct: 9 RSLCRASG-SRPAWAPAALTAPTSQEQPRRHYADKRIKVAKPVVEMDGDEMTRIIWQFIK 67
Query: 56 EKLILPHVDVPIEYYDLSITSRDASNDKVTEQAAEAIQRHNVGIKCATITPDEARVK--- 112
EKLILPHVD+ ++Y+DL + +RD ++D+VT +A A Q+++V +KCATITPDEARV+
Sbjct: 68 EKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDEARVEVGG 127
Query: 113 --------------------EFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRVVPQW 152
EF LKKMWKSPNGTIRNILGGTVFREPII KN+PR+VP W
Sbjct: 128 SWRTVLEIHLQTPQACPCPAEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGW 187
Query: 153 SEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNFKGEGVGLAMYNT 211
++PI +GRHA+GDQYKAT+ + G ++V TP +G + EV+NF GVG+ MYNT
Sbjct: 188 TKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMYNT 247
Query: 212 RESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFERLNLT 271
ES+ FA SCF+YAI +++PL +STKNTILK YDG F + FQ ++D Y+ F++ +
Sbjct: 248 DESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNKIW 307
Query: 272 YVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDGKTIES 331
Y HRLIDD VAQ++K +GGFVWACKNYDGDVQSDI+AQGFGSLGLMTSVL+CPDGKTIE+
Sbjct: 308 YEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEA 367
Query: 332 EAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLERATIK 391
EAAHGTVTRHYREHQKG+ TSTN +ASIFAWTRGL HRGKLDGN L+ FA +LE+ ++
Sbjct: 368 EAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQTLEKVCVE 427
Query: 392 TIEGGHMTKDLALCVHGAAALQ-RSHYETTEVFIDSVAEELARSV 435
T+E G MTKDLA C+HG + ++ H+ T F+D++ L R++
Sbjct: 428 TVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRAL 472
>emb|CAG13105.1| unnamed protein product [Tetraodon nigroviridis]
Length = 415
Score = 719 bits (1856), Expect = 0.0, Method: Composition-based stats.
Identities = 253/413 (61%), Positives = 329/413 (79%), Gaps = 2/413 (0%)
Query: 25 TRPSLGRIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKV 84
+ RIKV+ VV+MDGDEMTRIIW IKEKLIL +VDV ++Y+DL + RD ++D+V
Sbjct: 1 MTDADRRIKVAQPVVEMDGDEMTRIIWEFIKEKLILTNVDVELKYFDLGLPYRDQTDDQV 60
Query: 85 TEQAAEAIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKN 144
T +A A ++++V +KCATITPDEARV+EF LKKMWKSPNGTIRNILGGTVFREPII +N
Sbjct: 61 TIDSALATKKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICRN 120
Query: 145 VPRVVPQWSEPIIVGRHAYGDQYKATESLF-PPGRLELVHTPANGGSPQVLEVFNFKGEG 203
+PR+VP W++PI +GRHA+GDQY+AT+ + PG+ ++V +PA+G S + EV++F G
Sbjct: 121 IPRLVPGWTQPITIGRHAFGDQYRATDFVVDKPGKFKIVFSPADGSSAKEWEVYDFPAGG 180
Query: 204 VGLAMYNTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYRE 263
G+ MYNT ES+ FA SCF+YAI +++PL +STKNTILK YDG F + FQ +++ Y+
Sbjct: 181 CGMGMYNTDESITGFAHSCFQYAIGKKWPLYMSTKNTILKAYDGRFKDIFQDIFEKHYKP 240
Query: 264 QFERLNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLC 323
+F++L + Y HRLIDD VAQ++K +G FVWACKNYDGDVQSDI+AQGFGSLGLMTSVL+C
Sbjct: 241 EFDKLKIWYEHRLIDDMVAQVLKSSGAFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVC 300
Query: 324 PDGKTIESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFAS 383
PDGKTIE+EAAHGTVTRHYREHQKG+ TSTN +ASIFAWTRGL HRGKLDGN L++F+
Sbjct: 301 PDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNNDLIKFSQ 360
Query: 384 SLERATIKTIEGGHMTKDLALCVHGAAALQ-RSHYETTEVFIDSVAEELARSV 435
+LER ++T+E G MTKDLA C+HG ++ HY T F+D++ L +++
Sbjct: 361 TLERVCVETVESGTMTKDLAGCIHGLPNVKLNEHYVNTTDFLDAIRTNLDKAL 413
>ref|NP_970434.1| isocitrate dehydrogenase [Bdellovibrio bacteriovorus HD100]
emb|CAE81088.1| isocitrate dehydrogenase (NADP) [Bdellovibrio bacteriovorus HD100]
Length = 409
Score = 718 bits (1854), Expect = 0.0, Method: Composition-based stats.
Identities = 258/408 (63%), Positives = 322/408 (78%), Gaps = 2/408 (0%)
Query: 29 LGRIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQA 88
+ +IKV+ VV++DGDEMTRIIW IK++LILP++D+ I+YYDL + RDA+ND+VT A
Sbjct: 1 MKKIKVANPVVELDGDEMTRIIWKFIKQQLILPYLDIDIKYYDLGMEHRDATNDQVTVDA 60
Query: 89 AEAIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRV 148
AEAI+++NVGIKCATITPDEARVKEFNLK+MWKSPNGTIRNIL GTVFREPII KNVPR+
Sbjct: 61 AEAIKKYNVGIKCATITPDEARVKEFNLKQMWKSPNGTIRNILDGTVFREPIICKNVPRL 120
Query: 149 VPQWSEPIIVGRHAYGDQYKATESLF-PPGRLELVHTPANGGSPQVLEVFNFKGEGVGLA 207
VP W+ PI +GRHA+GDQY+AT+ + G+L + P NGG EV+NFKG+GV L
Sbjct: 121 VPNWTAPICIGRHAFGDQYRATDFVTKGKGKLTVTFQPENGGETITHEVYNFKGDGVALT 180
Query: 208 MYNTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFER 267
MYNT ES+ FA SCF A+ +++PL LSTKNTILKKYDG F + F+ +Y +++ +F+
Sbjct: 181 MYNTDESITGFARSCFNQALTKKWPLYLSTKNTILKKYDGRFKDIFEEIYQKEFKAKFDA 240
Query: 268 LNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDGK 327
+TY HRLIDD VA +K NG FVWACKNYDGDVQSD VAQGFGSLGLMTSVL+ PDGK
Sbjct: 241 AGITYEHRLIDDMVASALKWNGNFVWACKNYDGDVQSDTVAQGFGSLGLMTSVLVTPDGK 300
Query: 328 TIESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLER 387
T+ESEAAHGTVTRHYR+HQ+GK TSTN +ASIFAWTRGL HRG LD N LV+FA +LE+
Sbjct: 301 TMESEAAHGTVTRHYRQHQQGKPTSTNPIASIFAWTRGLEHRGNLDNNQELVKFAQTLEK 360
Query: 388 ATIKTIEGGHMTKDLALCVHGAAALQRSHYETTEVFIDSVAEELARSV 435
++T+E G MTKDLA+C++G + Y TE F+ + E L +++
Sbjct: 361 VCVETVEAGFMTKDLAVCIYGD-KVPADKYMNTEPFLAKLDENLKKAL 407
>ref|XP_001107627.1| PREDICTED: isocitrate dehydrogenase 1 (NADP+), soluble isoform 1
[Macaca mulatta]
ref|XP_001107810.1| PREDICTED: isocitrate dehydrogenase 1 (NADP+), soluble isoform 2
[Macaca mulatta]
ref|XP_001107875.1| PREDICTED: isocitrate dehydrogenase 1 (NADP+), soluble isoform 3
[Macaca mulatta]
ref|XP_001107934.1| PREDICTED: isocitrate dehydrogenase 1 (NADP+), soluble isoform 4
[Macaca mulatta]
ref|XP_001107992.1| PREDICTED: isocitrate dehydrogenase 1 (NADP+), soluble isoform 5
[Macaca mulatta]
Length = 414
Score = 718 bits (1854), Expect = 0.0, Method: Composition-based stats.
Identities = 255/410 (62%), Positives = 319/410 (77%), Gaps = 2/410 (0%)
Query: 29 LGRIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQA 88
+ + G+VV++ GDEMTRIIW LIKEKLI P+V++ ++ YDL I +RDA+ND+VT+ A
Sbjct: 1 MSKKISGGSVVELQGDEMTRIIWELIKEKLIFPYVELDLQSYDLGIENRDATNDQVTKDA 60
Query: 89 AEAIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRV 148
AEAI+++NVG+KCATITPDE RV+EF LK+MWKSPNGTIRNILGGTVFRE II KN+PR+
Sbjct: 61 AEAIKKYNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 149 VPQWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNFK-GEGVGL 206
V W +PII+GRHAYGDQY+AT+ + P PG++E+ +TP++G V NF+ G GV +
Sbjct: 121 VSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAM 180
Query: 207 AMYNTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFE 266
MYN +S+E FA S F+ A+ + +PL LSTKNTILKKYDG F + FQ +YD +Y+ QFE
Sbjct: 181 GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE 240
Query: 267 RLNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDG 326
+ Y HRLIDD VAQ +K GGF+WACKNYDGDVQSD VAQG+GSLG+MTSVL+CPDG
Sbjct: 241 AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG 300
Query: 327 KTIESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLE 386
KT+E+EAAHGTVTRHYR +QKG+ETSTN +ASIFAWTRGLAHR KLD N L FA++LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALE 360
Query: 387 RATIKTIEGGHMTKDLALCVHGAAALQRSHYETTEVFIDSVAEELARSVK 436
I+TIE G MTKDLA C+ G +QRS Y T F+D + E L +
Sbjct: 361 EVCIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLA 410
>ref|XP_847200.1| isocitrate dehydrogenase [NADP], mitochondrial precursor, putative
[Trypanosoma brucei TREU927]
gb|AAX78964.1| isocitrate dehydrogenase [NADP], mitochondrial precursor, putative
[Trypanosoma brucei]
gb|AAZ13134.1| isocitrate dehydrogenase [NADP], mitochondrial precursor, putative
[Trypanosoma brucei]
Length = 437
Score = 717 bits (1852), Expect = 0.0, Method: Composition-based stats.
Identities = 437/437 (100%), Positives = 437/437 (100%)
Query: 1 MFRRVACAASSVNAGALTPRFVSTTRPSLGRIKVSGTVVDMDGDEMTRIIWALIKEKLIL 60
MFRRVACAASSVNAGALTPRFVSTTRPSLGRIKVSGTVVDMDGDEMTRIIWALIKEKLIL
Sbjct: 1 MFRRVACAASSVNAGALTPRFVSTTRPSLGRIKVSGTVVDMDGDEMTRIIWALIKEKLIL 60
Query: 61 PHVDVPIEYYDLSITSRDASNDKVTEQAAEAIQRHNVGIKCATITPDEARVKEFNLKKMW 120
PHVDVPIEYYDLSITSRDASNDKVTEQAAEAIQRHNVGIKCATITPDEARVKEFNLKKMW
Sbjct: 61 PHVDVPIEYYDLSITSRDASNDKVTEQAAEAIQRHNVGIKCATITPDEARVKEFNLKKMW 120
Query: 121 KSPNGTIRNILGGTVFREPIIVKNVPRVVPQWSEPIIVGRHAYGDQYKATESLFPPGRLE 180
KSPNGTIRNILGGTVFREPIIVKNVPRVVPQWSEPIIVGRHAYGDQYKATESLFPPGRLE
Sbjct: 121 KSPNGTIRNILGGTVFREPIIVKNVPRVVPQWSEPIIVGRHAYGDQYKATESLFPPGRLE 180
Query: 181 LVHTPANGGSPQVLEVFNFKGEGVGLAMYNTRESVEAFAESCFEYAIMRRYPLVLSTKNT 240
LVHTPANGGSPQVLEVFNFKGEGVGLAMYNTRESVEAFAESCFEYAIMRRYPLVLSTKNT
Sbjct: 181 LVHTPANGGSPQVLEVFNFKGEGVGLAMYNTRESVEAFAESCFEYAIMRRYPLVLSTKNT 240
Query: 241 ILKKYDGLFLETFQRMYDTKYREQFERLNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDG 300
ILKKYDGLFLETFQRMYDTKYREQFERLNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDG
Sbjct: 241 ILKKYDGLFLETFQRMYDTKYREQFERLNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDG 300
Query: 301 DVQSDIVAQGFGSLGLMTSVLLCPDGKTIESEAAHGTVTRHYREHQKGKETSTNSVASIF 360
DVQSDIVAQGFGSLGLMTSVLLCPDGKTIESEAAHGTVTRHYREHQKGKETSTNSVASIF
Sbjct: 301 DVQSDIVAQGFGSLGLMTSVLLCPDGKTIESEAAHGTVTRHYREHQKGKETSTNSVASIF 360
Query: 361 AWTRGLAHRGKLDGNAPLVEFASSLERATIKTIEGGHMTKDLALCVHGAAALQRSHYETT 420
AWTRGLAHRGKLDGNAPLVEFASSLERATIKTIEGGHMTKDLALCVHGAAALQRSHYETT
Sbjct: 361 AWTRGLAHRGKLDGNAPLVEFASSLERATIKTIEGGHMTKDLALCVHGAAALQRSHYETT 420
Query: 421 EVFIDSVAEELARSVKG 437
EVFIDSVAEELARSVKG
Sbjct: 421 EVFIDSVAEELARSVKG 437
>ref|NP_001004799.1| MGC69505 protein [Xenopus tropicalis]
gb|AAH74545.1| MGC69505 protein [Xenopus tropicalis]
Length = 455
Score = 716 bits (1850), Expect = 0.0, Method: Composition-based stats.
Identities = 265/440 (60%), Positives = 331/440 (75%), Gaps = 8/440 (1%)
Query: 4 RVACAASSVNAGALTPRFVST-----TRPSLGRIKVSGTVVDMDGDEMTRIIWALIKEKL 58
R + AA N G L P + RIKV+ VV+MDGDEMTRIIW IKEKL
Sbjct: 13 RASAAALGKNPGVLAPALSQQQLQQQRNYADKRIKVANPVVEMDGDEMTRIIWEFIKEKL 72
Query: 59 ILPHVDVPIEYYDLSITSRDASNDKVTEQAAEAIQRHNVGIKCATITPDEARVKEFNLKK 118
IL +VDV ++Y+DL + RD +ND+VT +A A ++NV +KCATITPDEARV+EF LKK
Sbjct: 73 ILSNVDVELKYFDLGLPYRDQTNDQVTIDSALATLKYNVAVKCATITPDEARVEEFKLKK 132
Query: 119 MWKSPNGTIRNILGGTVFREPIIVKNVPRVVPQWSEPIIVGRHAYGDQYKATESLF-PPG 177
MWKSPNGTIRNILGGTVFR+PII KN+PR+VP W++ I +GRHA+GDQYKAT+ + G
Sbjct: 133 MWKSPNGTIRNILGGTVFRDPIICKNIPRLVPGWTQAITIGRHAHGDQYKATDFVVDQAG 192
Query: 178 RLELVHTPANGGSPQVLEVFNFKGEGVGLAMYNTRESVEAFAESCFEYAIMRRYPLVLST 237
+LV PANG + + EVFNF GVG+ MYNT ES+ FA SCF+Y+I +++PL LST
Sbjct: 193 TFKLVFAPANGTATKEWEVFNFPAGGVGMGMYNTDESISGFAHSCFQYSIQKKWPLYLST 252
Query: 238 KNTILKKYDGLFLETFQRMYDTKYREQFERLNLTYVHRLIDDQVAQMIKGNGGFVWACKN 297
KNTILK YDG F + FQ +++ Y+ +F++L + Y HRLIDD VAQ++K GGFVWACKN
Sbjct: 253 KNTILKAYDGRFKDIFQDIFEKHYKPEFDKLKIWYEHRLIDDMVAQVLKSTGGFVWACKN 312
Query: 298 YDGDVQSDIVAQGFGSLGLMTSVLLCPDGKTIESEAAHGTVTRHYREHQKGKETSTNSVA 357
YDGDVQSDI+AQGFGSLGLMTSVL+CPDGKTIE+EAAHGTVTRHYREHQKG+ TSTN +A
Sbjct: 313 YDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIA 372
Query: 358 SIFAWTRGLAHRGKLDGNAPLVEFASSLERATIKTIEGGHMTKDLALCVHG--AAALQRS 415
SIFAWTRGL HRGKLDGN L+ F+ +LE+ ++T+E G MTKDLA C+HG +
Sbjct: 373 SIFAWTRGLEHRGKLDGNQDLINFSLTLEKVCVETVESGIMTKDLAGCIHGGMSNVRLNE 432
Query: 416 HYETTEVFIDSVAEELARSV 435
HY T F+D++ L +++
Sbjct: 433 HYVNTTDFLDAIKNNLDKAL 452
>ref|NP_113698.1| isocitrate dehydrogenase 1 (NADP+), soluble [Rattus norvegicus]
sp|P41562|IDHC_RAT Isocitrate dehydrogenase [NADP] cytoplasmic (Cytosolic
NADP-isocitrate dehydrogenase) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP)
gb|AAA59356.1| cytosolic NADP-dependent isocitrate dehydrogenase
gb|EDL98861.1| isocitrate dehydrogenase 1 (NADP+), soluble, isoform CRA_a [Rattus
norvegicus]
gb|EDL98863.1| isocitrate dehydrogenase 1 (NADP+), soluble, isoform CRA_a [Rattus
norvegicus]
gb|EDL98864.1| isocitrate dehydrogenase 1 (NADP+), soluble, isoform CRA_a [Rattus
norvegicus]
gb|EDL98865.1| isocitrate dehydrogenase 1 (NADP+), soluble, isoform CRA_a [Rattus
norvegicus]
Length = 414
Score = 716 bits (1850), Expect = 0.0, Method: Composition-based stats.
Identities = 255/410 (62%), Positives = 318/410 (77%), Gaps = 2/410 (0%)
Query: 29 LGRIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQA 88
+ R G+VV+M GDEMTRIIW LIKEKLILP+V++ + YDL I +RDA+ND+VT+ A
Sbjct: 1 MSRKIHGGSVVEMQGDEMTRIIWELIKEKLILPYVELDLHSYDLGIENRDATNDQVTKDA 60
Query: 89 AEAIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRV 148
AEAI+++NVG+KCATITPDE RV+EF LK+MWKSPNGTIRNILGGTVFRE II KN+PR+
Sbjct: 61 AEAIKKYNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 149 VPQWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNFK-GEGVGL 206
V W +PII+GRHAYGDQY+AT+ + P PG++E+ +TP +G V +F+ G GV +
Sbjct: 121 VTGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPKDGSQKVTYLVHDFEEGGGVAM 180
Query: 207 AMYNTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFE 266
MYN +S+E FA S F+ A+ + +PL LSTKNTILKKYDG F + FQ +YD +Y+ +FE
Sbjct: 181 GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSKFE 240
Query: 267 RLNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDG 326
+ Y HRLIDD VAQ +K GGF+WACKNYDGDVQSD VAQG+GSLG+MTSVL+CPDG
Sbjct: 241 AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDG 300
Query: 327 KTIESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLE 386
KT+E+EAAHGTVTRHYR +QKG+ETSTN +ASIFAW+RGLAHR KLD N L FA++LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWSRGLAHRAKLDNNTELSFFANALE 360
Query: 387 RATIKTIEGGHMTKDLALCVHGAAALQRSHYETTEVFIDSVAEELARSVK 436
I+TIE G MTKDLA C+ G +QRS Y T F+D + E L +
Sbjct: 361 EVCIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKAKLA 410
>dbj|BAC77065.1| NADP-specific isocitrate dehydrogenase [Lupinus albus]
Length = 485
Score = 716 bits (1849), Expect = 0.0, Method: Composition-based stats.
Identities = 255/420 (60%), Positives = 328/420 (78%), Gaps = 3/420 (0%)
Query: 18 TPRFVSTTRPSLGRIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSR 77
+ R +T P+ R++V +V+MDGDEMTRIIW +IK+KLI P++D+ I+Y+DL + +R
Sbjct: 62 SLRCYAT-HPNFHRLQVLNPIVEMDGDEMTRIIWKMIKDKLIFPYLDLNIKYFDLGVENR 120
Query: 78 DASNDKVTEQAAEAIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFR 137
DA++D+VT ++AEA ++NV +KCATITPDE RVKEF LK MW+SPNGTIRNIL GTVFR
Sbjct: 121 DATDDRVTVESAEATLKYNVAVKCATITPDETRVKEFGLKSMWRSPNGTIRNILNGTVFR 180
Query: 138 EPIIVKNVPRVVPQWSEPIIVGRHAYGDQYKATESLF-PPGRLELVHTPANGGSPQVLEV 196
EPII +N+PR+VP W +PI +GRHA+GDQY+AT+++ PG+L+LV P +G +P L+V
Sbjct: 181 EPIICRNIPRIVPGWKKPICIGRHAFGDQYRATDAIIKGPGKLKLVFVPEDGEAPTELDV 240
Query: 197 FNFKGEGVGLAMYNTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRM 256
++FKG GV LAMYN ES+ AFAES A +++PL LSTKNTILKKYDG F + FQ +
Sbjct: 241 YDFKGPGVALAMYNIDESIRAFAESSMSLAFAKKWPLYLSTKNTILKKYDGRFKDIFQEV 300
Query: 257 YDTKYREQFERLNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGL 316
Y+ ++R+ FE ++ Y HRLIDD VA +K GG+VWACKNYDGDVQSD++AQGFGSLGL
Sbjct: 301 YEERWRQNFEEHSIWYEHRLIDDMVAYAVKSEGGYVWACKNYDGDVQSDLLAQGFGSLGL 360
Query: 317 MTSVLLCPDGKTIESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNA 376
MTSVLL DGKT+E+EAAHGTVTRH+R HQKG+ETSTNS+ASIFAWTRGL HR KLD N
Sbjct: 361 MTSVLLSSDGKTLEAEAAHGTVTRHFRLHQKGQETSTNSIASIFAWTRGLEHRAKLDNNE 420
Query: 377 PLVEFASSLERATIKTIEGGHMTKDLALCVHGAAALQRSHYETTEVFIDSVAEELARSVK 436
L +F LE A ++T+E G MTKDLAL +HG + R +Y TE FID+VA L R ++
Sbjct: 421 KLRDFTYKLEAACVETVESGKMTKDLALLIHGP-KVSREYYLNTEEFIDAVAHNLKRKLQ 479
>ref|NP_001088022.1| hypothetical protein LOC494713 [Xenopus laevis]
gb|AAH82651.1| LOC494713 protein [Xenopus laevis]
Length = 415
Score = 716 bits (1848), Expect = 0.0, Method: Composition-based stats.
Identities = 251/411 (61%), Positives = 316/411 (76%), Gaps = 2/411 (0%)
Query: 29 LGRIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQA 88
+ + G+VV+M GDEMTR+IW LIKEKLILP+V++ + YDL + +RDA++D+VT A
Sbjct: 1 MSKKINGGSVVEMQGDEMTRVIWDLIKEKLILPYVELDLHSYDLGMENRDATDDQVTVDA 60
Query: 89 AEAIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRV 148
AEAI+++NVGIKCATITPDE RV+EFNLK+MWKSPNGTIRNILGGTVFRE II KN+PR+
Sbjct: 61 AEAIKKYNVGIKCATITPDEKRVEEFNLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 149 VPQWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNFKG-EGVGL 206
V W +PII+GRHAYGDQY+AT+ + P PG++E+ TP +GG + NF+ GV L
Sbjct: 121 VSGWIKPIIIGRHAYGDQYRATDFVVPGPGKVEISFTPKDGGEAIKYVIHNFEDCGGVAL 180
Query: 207 AMYNTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFE 266
MYNT +S+ FA S F+ A+ + +PL +STKNTILK+YDG F + FQ +Y+ +Y+ QFE
Sbjct: 181 GMYNTDQSIRDFAHSSFQMALSKSWPLYMSTKNTILKRYDGRFKDIFQEIYEKEYKSQFE 240
Query: 267 RLNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDG 326
+ Y HRLIDD VAQ +K GGF+WACKNYDGDVQSD VAQG+GSLG+MTSVL+CPDG
Sbjct: 241 ENKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDG 300
Query: 327 KTIESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLE 386
KT+E+EAAHGTVTRHYR HQKG+ETSTN +ASIFAW+RGL HR KLD N L FA++LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMHQKGQETSTNPIASIFAWSRGLDHRAKLDNNQELKNFATALE 360
Query: 387 RATIKTIEGGHMTKDLALCVHGAAALQRSHYETTEVFIDSVAEELARSVKG 437
I+TIE G MTKDLA C+ G +QR Y +T F+D + E L +
Sbjct: 361 EVCIETIEAGFMTKDLAACIKGLPNVQRGDYLSTFEFMDKLGENLQLKLAA 411
>emb|CAG02362.1| unnamed protein product [Tetraodon nigroviridis]
Length = 438
Score = 715 bits (1847), Expect = 0.0, Method: Composition-based stats.
Identities = 261/436 (59%), Positives = 327/436 (75%), Gaps = 28/436 (6%)
Query: 28 SLGRIKVSGTVVDMDGDEMTRIIWALIKEK--------------------------LILP 61
+ RIKV VV+MDGDEMTRIIW IKEK LILP
Sbjct: 1 ATERIKVEQPVVEMDGDEMTRIIWEFIKEKVLKSSKRCRFFGGPAWFFPSPCVRPQLILP 60
Query: 62 HVDVPIEYYDLSITSRDASNDKVTEQAAEAIQRHNVGIKCATITPDEARVKEFNLKKMWK 121
+VDV ++Y+DL + RD ++D+VT +A A +++NV +KCATITPDEARV+EFNLKKMWK
Sbjct: 61 NVDVELKYFDLGLPYRDQTDDQVTIDSALATKKYNVAVKCATITPDEARVEEFNLKKMWK 120
Query: 122 SPNGTIRNILGGTVFREPIIVKNVPRVVPQWSEPIIVGRHAYGDQYKATESLF-PPGRLE 180
SPNGTIRNILGGTVFREPI+ KN+PR+VP W++PI +GRHA+GDQY+AT+ PG+ +
Sbjct: 121 SPNGTIRNILGGTVFREPILCKNIPRLVPGWTQPITIGRHAFGDQYRATDFTVNQPGKFK 180
Query: 181 LVHTPANGGSPQVLEVFNFKGEGVGLAMYNTRESVEAFAESCFEYAIMRRYPLVLSTKNT 240
++ PA+GG + EV++FK G G+ MYNT ES+ FA SCF+YAI +++PL +STKNT
Sbjct: 181 IIFAPADGGQQKEWEVYDFKSGGCGMGMYNTDESIWGFAHSCFQYAIQKKWPLYMSTKNT 240
Query: 241 ILKKYDGLFLETFQRMYDTKYREQFERLNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDG 300
ILK YDG F + FQ +Y+ Y+ +FE+L + Y HRLIDD VAQ++K +G FVWACKNYDG
Sbjct: 241 ILKAYDGRFKDIFQDIYEKDYQAEFEKLKIWYEHRLIDDMVAQVLKSSGAFVWACKNYDG 300
Query: 301 DVQSDIVAQGFGSLGLMTSVLLCPDGKTIESEAAHGTVTRHYREHQKGKETSTNSVASIF 360
DVQSDI+AQGFGSLGLMTSVL+CPDGKTIE+EAAHGTVTRHYREHQ+GK TSTN +ASIF
Sbjct: 301 DVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQRGKPTSTNPIASIF 360
Query: 361 AWTRGLAHRGKLDGNAPLVEFASSLERATIKTIEGGHMTKDLALCVHGAAALQ-RSHYET 419
AWTRGL HRGKLDGN L+ F +LER ++T+E G MTKDLA C+HG A + HY
Sbjct: 361 AWTRGLEHRGKLDGNPDLIRFCQTLERVCVETVESGVMTKDLAGCIHGLANCKLNEHYVN 420
Query: 420 TEVFIDSVAEELARSV 435
T F+D++ L RS+
Sbjct: 421 TTDFLDAIRTNLDRSL 436
>sp|Q9Z2K9|IDHC_MICME Isocitrate dehydrogenase [NADP] cytoplasmic (Cytosolic
NADP-isocitrate dehydrogenase) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP)
gb|AAD02924.1| cytosolic NADP-dependent isocitrate dehydrogenase [Microtus
mexicanus]
Length = 414
Score = 715 bits (1847), Expect = 0.0, Method: Composition-based stats.
Identities = 255/410 (62%), Positives = 316/410 (77%), Gaps = 2/410 (0%)
Query: 29 LGRIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQA 88
+ + G+VV+M GDEMTRIIW LIKEKLILP+V++ + YDL I +RDA+ND+VT+ A
Sbjct: 1 MSKKIHGGSVVEMQGDEMTRIIWELIKEKLILPYVELDLHSYDLGIENRDATNDQVTKDA 60
Query: 89 AEAIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRV 148
AEAI+++NVG+KCATITPDE RV+EF LK+MWKSPNGTIRNILGGTVFRE II KN+PR+
Sbjct: 61 AEAIKKYNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 149 VPQWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNFK-GEGVGL 206
V W +PII+GRHAYGDQY+AT+ + P PG++E+ TP +G V +F+ G GV +
Sbjct: 121 VTGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITFTPKDGSQKVTYLVHSFEEGGGVAM 180
Query: 207 AMYNTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFE 266
MYN +S+E FA S F+ A+ + +PL LSTKNTILKKYDG F + FQ +YD +Y+ QFE
Sbjct: 181 GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE 240
Query: 267 RLNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDG 326
+ Y HRLIDD VAQ +K GGF+WACKNYDGDVQSD VAQG+GSLG+MTSVL+CPDG
Sbjct: 241 AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDG 300
Query: 327 KTIESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLE 386
KT+E+EAAHGTVTRHYR HQKG+ETSTN +ASIFAW+RGLAHR +LD N L FA +LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMHQKGQETSTNPIASIFAWSRGLAHRARLDNNTELSFFAKALE 360
Query: 387 RATIKTIEGGHMTKDLALCVHGAAALQRSHYETTEVFIDSVAEELARSVK 436
I+TIE G MTKDLA C+ G +QRS Y T F+D + E L +
Sbjct: 361 EVCIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKAKLA 410
>ref|XP_421965.2| PREDICTED: similar to cytosolic NADP-dependent isocitrate
dehydrogenase [Gallus gallus]
Length = 415
Score = 715 bits (1846), Expect = 0.0, Method: Composition-based stats.
Identities = 255/410 (62%), Positives = 316/410 (77%), Gaps = 2/410 (0%)
Query: 29 LGRIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQA 88
+ + G+VV+M GDEMTR+IW LIKEKLI P+VD+ + YDL I RDA+NDKVT +A
Sbjct: 1 MSKKIHGGSVVEMQGDEMTRVIWELIKEKLIFPYVDLDLHSYDLGIEHRDATNDKVTVEA 60
Query: 89 AEAIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRV 148
AEAI++++VGIKCATITPDE RV+EF LK+MWKSPNGTIRNILGGTVFRE II KN+PR+
Sbjct: 61 AEAIKKYHVGIKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 149 VPQWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNFKG-EGVGL 206
V W +PI++GRHAYGDQY+AT+ + P PG++E+ +TP +GG P V NF+ GV +
Sbjct: 121 VSGWVKPIVIGRHAYGDQYRATDFVVPGPGKVEMTYTPGDGGKPVTYLVHNFESCGGVAM 180
Query: 207 AMYNTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFE 266
MYN +S++ FA S F+ A+ + +PL +STKNTILK+YDG F + FQ +YD +Y+ QFE
Sbjct: 181 GMYNLDQSIKDFAHSSFQMALSKGWPLYMSTKNTILKRYDGRFKDIFQEIYDREYKSQFE 240
Query: 267 RLNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDG 326
+ Y HRLIDD VAQ +K GGFVWACKNYDGDVQSD VAQG+GSLG+MTSVL+CPDG
Sbjct: 241 AKKIWYEHRLIDDMVAQALKSEGGFVWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDG 300
Query: 327 KTIESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLE 386
KT+E+EAAHGTVTRHYR HQKG+ETSTN +ASIFAWTRGLAHR KLD N L FA++LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMHQKGQETSTNPIASIFAWTRGLAHRAKLDNNTSLKTFATALE 360
Query: 387 RATIKTIEGGHMTKDLALCVHGAAALQRSHYETTEVFIDSVAEELARSVK 436
I+TIE G MTKDLA C+ G + RS Y T F+D +A L +
Sbjct: 361 EVCIETIESGFMTKDLAACIKGLPNVTRSDYLNTFEFMDKLAANLKGKLA 410
>ref|XP_850187.1| PREDICTED: similar to Isocitrate dehydrogenase [NADP] cytoplasmic
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) (IDP) isoform 2 [Canis familiaris]
ref|XP_536047.2| PREDICTED: similar to Isocitrate dehydrogenase [NADP] cytoplasmic
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) (IDP) isoform 1 [Canis familiaris]
Length = 414
Score = 715 bits (1846), Expect = 0.0, Method: Composition-based stats.
Identities = 257/409 (62%), Positives = 319/409 (77%), Gaps = 3/409 (0%)
Query: 30 GRIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQAA 89
+I+ G+VV+M GDEMTRIIW LIKEKLI P+V++ + YDL I +RDA+ND+VT+ AA
Sbjct: 3 QKIRG-GSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAA 61
Query: 90 EAIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRVV 149
EAI+++NVG+KCATITPDE RV+EF LK+MWKSPNGTIRNILGGTVFRE II KN+PR+V
Sbjct: 62 EAIKKYNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLV 121
Query: 150 PQWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNFK-GEGVGLA 207
W +PII+GRHAYGDQY+AT+ + P PG++E+ +TP++G V NF+ G GV +
Sbjct: 122 SGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGSEKMTYLVHNFEEGGGVAMG 181
Query: 208 MYNTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFER 267
MYN +S+E FA S F+ A+ + +PL LSTKNTILKKYDG F + FQ +YD +Y+ QFE
Sbjct: 182 MYNQDKSIEDFAHSSFQMALSKSWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEA 241
Query: 268 LNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDGK 327
N+ Y HRLIDD VAQ +K GGF+WACKNYDGDVQSD VAQG+GSLG+MTSVL+CPDGK
Sbjct: 242 QNIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGK 301
Query: 328 TIESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLER 387
T+E+EAAHGTVTRHYR +QKG+ETSTN +ASIFAWTRGLAHR KLD N L FA +LE
Sbjct: 302 TVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELSFFAKALEE 361
Query: 388 ATIKTIEGGHMTKDLALCVHGAAALQRSHYETTEVFIDSVAEELARSVK 436
++TIE G MTKDLA C+ G +QRS Y T F+D + E L +
Sbjct: 362 VCVETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLNIKLA 410
>emb|CAG38738.1| IDH1 [Homo sapiens]
Length = 414
Score = 715 bits (1846), Expect = 0.0, Method: Composition-based stats.
Identities = 257/410 (62%), Positives = 319/410 (77%), Gaps = 2/410 (0%)
Query: 29 LGRIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQA 88
+ + G+VV+M GDEMTRIIW LIKEKLI P+V++ + YDL I +RDA+ND+VT+ A
Sbjct: 1 MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDA 60
Query: 89 AEAIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRV 148
AEAI++HNVG+KCATITPDE RV+EF LK+MWKSPNGTIRNILGGTVFRE II KN+PR+
Sbjct: 61 AEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 149 VPQWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNFK-GEGVGL 206
V W +PII+GRHAYGDQY+AT+ + P PG++E+ +TP++G V NF+ G GV +
Sbjct: 121 VSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEMTYTPSDGTQKVTYLVHNFEEGGGVAM 180
Query: 207 AMYNTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFE 266
MYN +S+E FA S F+ A+ + +PL LSTKNTILKKYDG F + FQ +YD +Y+ QFE
Sbjct: 181 GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE 240
Query: 267 RLNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDG 326
+ Y HRLIDD VAQ +K GGF+WACKNYDGDVQSD VAQG+GSLG+MTSVL+CPDG
Sbjct: 241 AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG 300
Query: 327 KTIESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLE 386
KT+E+EAAHGTVTRHYR +QKG+ETSTN +ASIFAWTRGLAHR KLD N L FA++LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALE 360
Query: 387 RATIKTIEGGHMTKDLALCVHGAAALQRSHYETTEVFIDSVAEELARSVK 436
+I+TIE G MTKDLA C+ G +QRS Y T F+D + E L +
Sbjct: 361 EVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLA 410
>ref|NP_851355.2| isocitrate dehydrogenase 1 (NADP+), soluble [Bos taurus]
gb|AAI03369.1| Isocitrate dehydrogenase 1 (NADP+), soluble [Bos taurus]
Length = 414
Score = 714 bits (1845), Expect = 0.0, Method: Composition-based stats.
Identities = 257/409 (62%), Positives = 318/409 (77%), Gaps = 3/409 (0%)
Query: 30 GRIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQAA 89
+I+ G+VV+M GDEMTRIIW LIKEKLI P+V++ + YDL I +RDA+ND+VT+ AA
Sbjct: 3 QKIQG-GSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAA 61
Query: 90 EAIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRVV 149
EAI+++NVG+KCATITPDE RV+EF LK+MWKSPNGTIRNILGGTVFRE II KN+PR+V
Sbjct: 62 EAIKKYNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLV 121
Query: 150 PQWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNFK-GEGVGLA 207
W +PII+GRHAYGDQY+AT+ + P PG++E+ +TP++G V V NF GV +
Sbjct: 122 SGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEISYTPSDGSPKTVYLVHNFTESGGVAMG 181
Query: 208 MYNTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFER 267
MYN +S+E FA S F+ A+ + +PL LSTKNTILKKYDG F + FQ +YD +Y+ +FE
Sbjct: 182 MYNQDKSIEDFAHSSFQMALSKNWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSEFEA 241
Query: 268 LNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDGK 327
N+ Y HRLIDD VAQ +K GGF+WACKNYDGDVQSD VAQG+GSLG+MTSVL+CPDGK
Sbjct: 242 QNIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGK 301
Query: 328 TIESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLER 387
T+E+EAAHGTVTRHYR +QKG+ETSTN +ASIFAWTRGLAHR KLD N L FA +LE
Sbjct: 302 TVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELSFFAKALEE 361
Query: 388 ATIKTIEGGHMTKDLALCVHGAAALQRSHYETTEVFIDSVAEELARSVK 436
I+TIE G MTKDLA C+ G +QRS Y T F+D + E L +
Sbjct: 362 VCIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLQLKLA 410
>ref|XP_001168261.1| PREDICTED: isocitrate dehydrogenase 2 (NADP+), mitochondrial
isoform 1 [Pan troglodytes]
Length = 479
Score = 714 bits (1845), Expect = 0.0, Method: Composition-based stats.
Identities = 263/469 (56%), Positives = 335/469 (71%), Gaps = 38/469 (8%)
Query: 4 RVACAASSVNAGALTPRFVSTTRP--------SLGRIKVSGTVVDMDGDEMTRIIWALIK 55
R C AS + A P ++ + RIKV+ VV+MDGDEMTRIIW IK
Sbjct: 9 RSLCRASG-SRPAWAPAALTAPTSQEQPRRHYADKRIKVAKPVVEMDGDEMTRIIWQFIK 67
Query: 56 EKLILPHVDVPIEYYDLSITSRDASNDKVTEQAAEAIQRHNVGIKCATITPDEARVKE-- 113
EKLILPHVD+ ++Y+DL + +RD ++D+VT +A A Q+++V +KCATITPDEARV+
Sbjct: 68 EKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDEARVEGQW 127
Query: 114 -------------------------FNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRV 148
F LKKMWKSPNGTIRNILGGTVFREPII KN+PR+
Sbjct: 128 CFCYTLALTVVGVIGDRAEEEEEEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRL 187
Query: 149 VPQWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNFKGEGVGLA 207
VP W++PI +GRHA+GDQYKAT+ + G ++V TP +G + EV+NF GVG+
Sbjct: 188 VPGWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMG 247
Query: 208 MYNTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFER 267
MYNT ES+ FA SCF+YAI +++PL +STKNTILK YDG F + FQ ++D Y+ F++
Sbjct: 248 MYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDK 307
Query: 268 LNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDGK 327
+ Y HRLIDD VAQ++K +GGFVWACKNYDGDVQSDI+AQGFGSLGLMTSVL+CPDGK
Sbjct: 308 NKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGK 367
Query: 328 TIESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLER 387
TIE+EAAHGTVTRHYREHQKG+ TSTN +ASIFAWTRGL HRGKLDGN L+ FA +LE+
Sbjct: 368 TIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQTLEK 427
Query: 388 ATIKTIEGGHMTKDLALCVHGAAALQ-RSHYETTEVFIDSVAEELARSV 435
++T+E G MTKDLA C+HG + ++ H+ T F+D++ L R++
Sbjct: 428 VCVETVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRAL 476
>sp|Q9Z2K8|IDHC_MICOH Isocitrate dehydrogenase [NADP] cytoplasmic (Cytosolic
NADP-isocitrate dehydrogenase) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP)
gb|AAD02925.1| cytosolic NADP-dependent isocitrate dehydrogenase [Microtus
ochrogaster]
Length = 414
Score = 714 bits (1845), Expect = 0.0, Method: Composition-based stats.
Identities = 255/410 (62%), Positives = 317/410 (77%), Gaps = 2/410 (0%)
Query: 29 LGRIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQA 88
+ + G+VV+M GDEMTRIIW LIKEKLILP+V++ + YDL I +RDA+ND+VT+ A
Sbjct: 1 MSKKIHGGSVVEMQGDEMTRIIWELIKEKLILPYVELDLHSYDLGIENRDATNDQVTKDA 60
Query: 89 AEAIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRV 148
AEAI+++NVG+KCATITPDE RV+EF LK+MWKSPNGTIRNILGGTVFRE II KN+PR+
Sbjct: 61 AEAIKKYNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 149 VPQWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNFK-GEGVGL 206
V W +PII+GRHAYGDQY+AT+ + P PG++E+ +TP +G V +F+ G GV +
Sbjct: 121 VTGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPKDGSQKVTYLVHSFEEGGGVAM 180
Query: 207 AMYNTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFE 266
MYN +S+E FA S F+ A+ + +PL LSTKNTILKKYDG F + FQ +YD +Y+ QFE
Sbjct: 181 GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE 240
Query: 267 RLNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDG 326
+ Y HRLIDD VAQ +K GGF+WACKNYDGDVQSD VAQG+GSLG+MTSVL+CPDG
Sbjct: 241 AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDG 300
Query: 327 KTIESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLE 386
KT+E+EAAHGTVTRHYR HQKG+ETSTN +ASIFAW+RGLAHR +LD N L FA +LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMHQKGQETSTNPIASIFAWSRGLAHRARLDNNTELSFFAKALE 360
Query: 387 RATIKTIEGGHMTKDLALCVHGAAALQRSHYETTEVFIDSVAEELARSVK 436
I+TIE G MTKDLA C+ G +QRS Y T F+D + E L +
Sbjct: 361 EVCIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKAKLA 410
>gb|ABU41004.1| isocitrate dehydrogenase 1 [Anser anser]
Length = 415
Score = 714 bits (1844), Expect = 0.0, Method: Composition-based stats.
Identities = 255/410 (62%), Positives = 317/410 (77%), Gaps = 2/410 (0%)
Query: 29 LGRIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQA 88
+ + G+VV+M GDEMTR+IW LIKEKLI P+VD+ + YDL I RDA+NDKVT +A
Sbjct: 1 MSKKIHGGSVVEMQGDEMTRVIWELIKEKLIFPYVDLDLHSYDLGIEHRDATNDKVTVEA 60
Query: 89 AEAIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRV 148
AEAI++++VGIKCATITPDE RV+EF LK+MWKSPNGTIRNILGGTVFRE II KN+PR+
Sbjct: 61 AEAIKKYHVGIKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 149 VPQWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNFKG-EGVGL 206
V W +PI++GRHAYGDQY+AT+ + P PG++E+ +TP +GG P V NF+ GV +
Sbjct: 121 VSGWVKPIVIGRHAYGDQYRATDFVVPGPGKVEMTYTPGDGGKPVTYLVHNFESCGGVAM 180
Query: 207 AMYNTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFE 266
M+N +S++ FA S F+ A+ + +PL +STKNTILK+YDG F + FQ +YD +Y+ QFE
Sbjct: 181 GMFNLDQSIKDFAHSSFQMALSKGWPLYMSTKNTILKRYDGRFKDIFQEIYDREYKSQFE 240
Query: 267 RLNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDG 326
+ Y HRLIDD VAQ +K GGFVWACKNYDGDVQSD VAQG+GSLG+MTSVL+CPDG
Sbjct: 241 AKKIWYEHRLIDDMVAQALKSEGGFVWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDG 300
Query: 327 KTIESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLE 386
KT+E+EAAHGTVTRHYR HQKG+ETSTN +ASIFAWTRGLAHR KLD N L FA++LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMHQKGQETSTNPIASIFAWTRGLAHRAKLDNNTSLKTFAAALE 360
Query: 387 RATIKTIEGGHMTKDLALCVHGAAALQRSHYETTEVFIDSVAEELARSVK 436
I+TIE G MTKDLA C+ G + RS Y T F+D +AE L +
Sbjct: 361 EVCIETIESGFMTKDLAACIKGLPNVTRSDYLNTFEFMDKLAENLKGKLA 410
>ref|NP_005887.2| isocitrate dehydrogenase 1 (NADP+), soluble [Homo sapiens]
sp|O75874|IDHC_HUMAN Isocitrate dehydrogenase [NADP] cytoplasmic (Cytosolic
NADP-isocitrate dehydrogenase) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP)
pdb|1T09|A Chain A, Crystal Structure Of Human Cytosolic Nadp(+)-Dependent
Isocitrate Dehydrogenase In Complex Nadp
pdb|1T09|B Chain B, Crystal Structure Of Human Cytosolic Nadp(+)-Dependent
Isocitrate Dehydrogenase In Complex Nadp
pdb|1T0L|A Chain A, Crystal Structure Of Human Cytosolic Nadp(+)-Dependent
Isocitrate Dehydrogenase In Complex With Nadp,
Isocitrate, And Calcium(2+)
pdb|1T0L|B Chain B, Crystal Structure Of Human Cytosolic Nadp(+)-Dependent
Isocitrate Dehydrogenase In Complex With Nadp,
Isocitrate, And Calcium(2+)
pdb|1T0L|C Chain C, Crystal Structure Of Human Cytosolic Nadp(+)-Dependent
Isocitrate Dehydrogenase In Complex With Nadp,
Isocitrate, And Calcium(2+)
pdb|1T0L|D Chain D, Crystal Structure Of Human Cytosolic Nadp(+)-Dependent
Isocitrate Dehydrogenase In Complex With Nadp,
Isocitrate, And Calcium(2+)
gb|AAD29284.1|AF113917_1 NADP+-dependent isocitrate dehydrogenase [Homo sapiens]
gb|AAH12846.1| IDH1 protein [Homo sapiens]
emb|CAG46496.1| IDH1 [Homo sapiens]
gb|AAX93221.1| unknown [Homo sapiens]
gb|EAW70439.1| isocitrate dehydrogenase 1 (NADP+), soluble, isoform CRA_a [Homo
sapiens]
gb|EAW70441.1| isocitrate dehydrogenase 1 (NADP+), soluble, isoform CRA_a [Homo
sapiens]
gb|EAW70442.1| isocitrate dehydrogenase 1 (NADP+), soluble, isoform CRA_a [Homo
sapiens]
gb|ABM82361.1| isocitrate dehydrogenase 1 (NADP+), soluble [synthetic construct]
gb|ABW03396.1| isocitrate dehydrogenase 1 (NADP+), soluble [synthetic construct]
Length = 414
Score = 714 bits (1844), Expect = 0.0, Method: Composition-based stats.
Identities = 257/410 (62%), Positives = 319/410 (77%), Gaps = 2/410 (0%)
Query: 29 LGRIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQA 88
+ + G+VV+M GDEMTRIIW LIKEKLI P+V++ + YDL I +RDA+ND+VT+ A
Sbjct: 1 MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDA 60
Query: 89 AEAIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRV 148
AEAI++HNVG+KCATITPDE RV+EF LK+MWKSPNGTIRNILGGTVFRE II KN+PR+
Sbjct: 61 AEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 149 VPQWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNFK-GEGVGL 206
V W +PII+GRHAYGDQY+AT+ + P PG++E+ +TP++G V NF+ G GV +
Sbjct: 121 VSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAM 180
Query: 207 AMYNTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFE 266
MYN +S+E FA S F+ A+ + +PL LSTKNTILKKYDG F + FQ +YD +Y+ QFE
Sbjct: 181 GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE 240
Query: 267 RLNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDG 326
+ Y HRLIDD VAQ +K GGF+WACKNYDGDVQSD VAQG+GSLG+MTSVL+CPDG
Sbjct: 241 AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG 300
Query: 327 KTIESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLE 386
KT+E+EAAHGTVTRHYR +QKG+ETSTN +ASIFAWTRGLAHR KLD N L FA++LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALE 360
Query: 387 RATIKTIEGGHMTKDLALCVHGAAALQRSHYETTEVFIDSVAEELARSVK 436
+I+TIE G MTKDLA C+ G +QRS Y T F+D + E L +
Sbjct: 361 EVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLA 410
>ref|XP_001141655.1| PREDICTED: isocitrate dehydrogenase 1 (NADP+), soluble isoform 1
[Pan troglodytes]
ref|XP_001141734.1| PREDICTED: isocitrate dehydrogenase 1 (NADP+), soluble isoform 2
[Pan troglodytes]
ref|XP_001141810.1| PREDICTED: isocitrate dehydrogenase 1 (NADP+), soluble isoform 3
[Pan troglodytes]
ref|XP_001141879.1| PREDICTED: isocitrate dehydrogenase 1 (NADP+), soluble isoform 4
[Pan troglodytes]
ref|XP_001141947.1| PREDICTED: isocitrate dehydrogenase 1 (NADP+), soluble isoform 5
[Pan troglodytes]
ref|XP_001142041.1| PREDICTED: isocitrate dehydrogenase 1 (NADP+), soluble isoform 6
[Pan troglodytes]
ref|XP_001142113.1| PREDICTED: isocitrate dehydrogenase 1 (NADP+), soluble isoform 7
[Pan troglodytes]
ref|XP_001142197.1| PREDICTED: isocitrate dehydrogenase 1 (NADP+), soluble isoform 8
[Pan troglodytes]
Length = 414
Score = 713 bits (1842), Expect = 0.0, Method: Composition-based stats.
Identities = 256/410 (62%), Positives = 319/410 (77%), Gaps = 2/410 (0%)
Query: 29 LGRIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQA 88
+ + G+VV+M GDEMTRIIW LIKEKLI P+V++ + YDL I +RDA+ND+VT+ A
Sbjct: 1 MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDA 60
Query: 89 AEAIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRV 148
AEAI+++NVG+KCATITPDE RV+EF LK+MWKSPNGTIRNILGGTVFRE II KN+PR+
Sbjct: 61 AEAIKKYNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 149 VPQWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNFK-GEGVGL 206
V W +PII+GRHAYGDQY+AT+ + P PG++E+ +TP++G V NF+ G GV +
Sbjct: 121 VSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAM 180
Query: 207 AMYNTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFE 266
MYN +S+E FA S F+ A+ + +PL LSTKNTILKKYDG F + FQ +YD +Y+ QFE
Sbjct: 181 GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKRYKSQFE 240
Query: 267 RLNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDG 326
+ Y HRLIDD VAQ +K GGF+WACKNYDGDVQSD VAQG+GSLG+MTSVL+CPDG
Sbjct: 241 AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG 300
Query: 327 KTIESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLE 386
KT+E+EAAHGTVTRHYR +QKG+ETSTN +ASIFAWTRGLAHR KLD N L FA++LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALE 360
Query: 387 RATIKTIEGGHMTKDLALCVHGAAALQRSHYETTEVFIDSVAEELARSVK 436
+I+TIE G MTKDLA C+ G +QRS Y T F+D + E L +
Sbjct: 361 EVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLA 410
>sp|Q5R9C5|IDHC_PONPY Isocitrate dehydrogenase [NADP] cytoplasmic (Cytosolic
NADP-isocitrate dehydrogenase) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP)
Length = 414
Score = 713 bits (1842), Expect = 0.0, Method: Composition-based stats.
Identities = 255/410 (62%), Positives = 319/410 (77%), Gaps = 2/410 (0%)
Query: 29 LGRIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQA 88
+ + G+VV+M GDEMTRIIW LIKEKLI P+V++ + YDL I +RDA+ND+VT+ A
Sbjct: 1 MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDA 60
Query: 89 AEAIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRV 148
AEAI+++NVG+KCATITPDE RV+EF LK+MWKSPNGTIRNILGGTVFRE II KN+PR+
Sbjct: 61 AEAIKKYNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 149 VPQWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNFK-GEGVGL 206
V W +PII+GRHAYGDQY+AT+ + P PG++E+ +TP++G V NF+ G GV +
Sbjct: 121 VSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAM 180
Query: 207 AMYNTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFE 266
MYN +S+E FA S F+ A+ + +PL LSTKNTILKKYDG F + FQ +YD +Y+ QFE
Sbjct: 181 GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE 240
Query: 267 RLNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDG 326
+ Y HRLIDD VAQ +K GGF+WACKNYDGDVQSD VAQG+GSLG+MTSVL+CPDG
Sbjct: 241 ARKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG 300
Query: 327 KTIESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLE 386
KT+E+EAAHGTVTRHYR +QKG+ETSTN +ASIFAWTRGLAHR KLD N L FA++LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALE 360
Query: 387 RATIKTIEGGHMTKDLALCVHGAAALQRSHYETTEVFIDSVAEELARSVK 436
+++TIE G MTKDLA C+ G +QRS Y T F+D + E L +
Sbjct: 361 EVSVETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLA 410
>ref|XP_001778805.1| predicted protein [Physcomitrella patens subsp. patens]
gb|EDQ56391.1| predicted protein [Physcomitrella patens subsp. patens]
Length = 411
Score = 713 bits (1842), Expect = 0.0, Method: Composition-based stats.
Identities = 260/412 (63%), Positives = 330/412 (80%), Gaps = 4/412 (0%)
Query: 27 PSLGRIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTE 86
+ +I V+ +V+MDGDEMTRIIW +IK+KLI P +D+ ++Y+DL I RDA++D+VT
Sbjct: 1 MAFAKIHVANPIVEMDGDEMTRIIWKMIKDKLIFPFLDLDLKYFDLGIEHRDATDDRVTI 60
Query: 87 QAAEAIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVP 146
++AEA +++NV +KCATITPDEARVKE+NLK MW+SPNGTIRNIL GTVFREPI+ KN+P
Sbjct: 61 ESAEATKKYNVAVKCATITPDEARVKEYNLKSMWRSPNGTIRNILNGTVFREPILCKNIP 120
Query: 147 RVVPQWSEPIIVGRHAYGDQYKATESLF-PPGRLELVHTPANGGSPQVLEVFNFKG-EGV 204
++VP W+ PI +GRHA+GDQYKAT+++F PG+L++V P NGG Q L V++F+G GV
Sbjct: 121 KLVPGWTSPICIGRHAFGDQYKATDAVFKGPGKLKMVFVPENGGETQDLTVYDFEGAGGV 180
Query: 205 GLAMYNTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTK-YRE 263
L MYNT ES+ +FAES A +++PL LSTKNTILKKYDG F + FQ +Y+ + ++
Sbjct: 181 ALTMYNTDESIRSFAESSMAMAYEKKWPLYLSTKNTILKKYDGRFKDIFQEVYEQEGWKA 240
Query: 264 QFERLNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLC 323
+F+ + Y HRLIDD VA +K GG+VWACKNYDGDVQSD++AQGFGSLGLMTSVL+C
Sbjct: 241 KFDAAGIWYEHRLIDDMVAYALKSEGGYVWACKNYDGDVQSDMLAQGFGSLGLMTSVLVC 300
Query: 324 PDGKTIESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFAS 383
PDGKTIE+EAAHGTVTRHYR HQKG ETSTNS+ASIFAWTRGL+HRGKLDGN LV+FA+
Sbjct: 301 PDGKTIEAEAAHGTVTRHYRVHQKGGETSTNSIASIFAWTRGLSHRGKLDGNEKLVDFAT 360
Query: 384 SLERATIKTIEGGHMTKDLALCVHGAAALQRSHYETTEVFIDSVAEELARSV 435
LE+A + T+E G MTKDLAL +HG + L R Y TE FID+VAEEL +
Sbjct: 361 KLEQACVGTVENGKMTKDLALLIHG-SKLSRDTYLNTEEFIDAVAEELKSKL 411
>ref|NP_539708.1| isocitrate dehydrogenase [Brucella melitensis 16M]
ref|YP_221903.1| isocitrate dehydrogenase [Brucella abortus biovar 1 str. 9-941]
ref|YP_414607.1| isocitrate dehydrogenase [Brucella melitensis biovar Abortus 2308]
ref|YP_001259118.1| isocitrate dehydrogenase [Brucella ovis ATCC 25840]
ref|YP_001935116.1| Isocitrate/isopropylmalate dehydrogenase [Brucella abortus S19]
gb|AAL51972.1| ISOCITRATE DEHYDROGENASE (NADP) [Brucella melitensis 16M]
gb|AAX74542.1| isocitrate dehydrogenase, NADP-dependent [Brucella abortus biovar 1
str. 9-941]
emb|CAJ11177.1| Isocitrate/isopropylmalate dehydrogenase:Isocitrate dehydrogenase
NADP-dependent, eukaryotic [Brucella melitensis biovar
Abortus 2308]
gb|ABQ61375.1| isocitrate dehydrogenase, NADP-dependent [Brucella ovis ATCC 25840]
gb|ACD72642.1| Isocitrate/isopropylmalate dehydrogenase [Brucella abortus S19]
Length = 404
Score = 713 bits (1842), Expect = 0.0, Method: Composition-based stats.
Identities = 248/410 (60%), Positives = 312/410 (76%), Gaps = 7/410 (1%)
Query: 29 LGRIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQA 88
+ +IKV+ VV++DGDEMTRIIW IK+KLI P++D+ ++YYDLS+ +RDA+ND+VT A
Sbjct: 1 MAKIKVANPVVELDGDEMTRIIWQFIKDKLIHPYLDIDLKYYDLSVENRDATNDQVTIDA 60
Query: 89 AEAIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRV 148
A AI+ + VG+KCATITPDEARV+EF LKKMWKSPNGTIRNILGG +FREPII KNVPR+
Sbjct: 61 ANAIKEYGVGVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGVIFREPIICKNVPRL 120
Query: 149 VPQWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNFKGEGVGLA 207
VP W++PIIVGRHA+GDQY+AT+ FP G L + +G EV+ GV +A
Sbjct: 121 VPGWTQPIIVGRHAFGDQYRATDFKFPGKGTLTIKFVGEDG-QTIEHEVYQAPSAGVAMA 179
Query: 208 MYNTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFER 267
MYN ES+ FA + F Y + R YP+ LSTKNTILK YDG F + FQ ++D +++ +FE
Sbjct: 180 MYNLDESIREFARASFNYGLQRGYPVYLSTKNTILKAYDGRFKDIFQEVFDAEFKSKFEE 239
Query: 268 LNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDGK 327
+ Y HRLIDD VA +K +GG+VWACKNYDGDVQSDIVAQGFGSLGLMTSVL+ PDGK
Sbjct: 240 KKIWYEHRLIDDMVASALKWSGGYVWACKNYDGDVQSDIVAQGFGSLGLMTSVLMTPDGK 299
Query: 328 TIESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLER 387
T+E+EAAHGTVTRHYR+HQKG+ETSTNS+ASIFAWTRGLAHR KLD NA L +FA +LE+
Sbjct: 300 TVEAEAAHGTVTRHYRQHQKGEETSTNSIASIFAWTRGLAHRAKLDNNADLKKFAETLEK 359
Query: 388 ATIKTIEGGHMTKDLALCVHGAAALQRSHYETTEVFIDSVAEELARSVKG 437
+ T+E G MTKDLAL + + +T F+D + E L +++
Sbjct: 360 VCVDTVESGFMTKDLALLIG-----PDQPWLSTTGFLDKIDENLQKAMAA 404
>emb|CAH89719.1| hypothetical protein [Pongo abelii]
Length = 414
Score = 713 bits (1842), Expect = 0.0, Method: Composition-based stats.
Identities = 254/410 (61%), Positives = 318/410 (77%), Gaps = 2/410 (0%)
Query: 29 LGRIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQA 88
+ + G+VV+M GDEMTRIIW IKEKLI P+V++ + YDL I +RDA+ND+VT+ A
Sbjct: 1 MSKKISGGSVVEMQGDEMTRIIWEQIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDA 60
Query: 89 AEAIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRV 148
AEAI+++NVG+KCATITPDE RV+EF LK+MWKSPNGTIRNILGGTVFRE II KN+PR+
Sbjct: 61 AEAIKKYNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 149 VPQWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNFK-GEGVGL 206
V W +PII+GRHAYGDQY+AT+ + P PG++E+ +TP++G V NF+ G GV +
Sbjct: 121 VSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAM 180
Query: 207 AMYNTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFE 266
MYN +S+E FA S F+ A+ + +PL LSTKNTILKKYDG F + FQ +YD +Y+ QFE
Sbjct: 181 GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE 240
Query: 267 RLNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDG 326
+ Y HRLIDD VAQ +K GGF+WACKNYDGDVQSD VAQG+GSLG+MTSVL+CPDG
Sbjct: 241 ARKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG 300
Query: 327 KTIESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLE 386
KT+E+EAAHGTVTRHYR +QKG+ETSTN +ASIFAWTRGLAHR KLD N L FA++LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALE 360
Query: 387 RATIKTIEGGHMTKDLALCVHGAAALQRSHYETTEVFIDSVAEELARSVK 436
+++TIE G MTKDLA C+ G +QRS Y T F+D + E L +
Sbjct: 361 EVSVETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLA 410
>ref|NP_001009276.1| cytosolic NADP-isocitrate dehydrogenase [Ovis aries]
sp|Q6XUZ5|IDHC_SHEEP Isocitrate dehydrogenase [NADP] cytoplasmic (Cytosolic
NADP-isocitrate dehydrogenase) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP)
gb|AAP41947.1| cytosolic NADP-isocitrate dehydrogenase [Ovis aries]
Length = 414
Score = 713 bits (1841), Expect = 0.0, Method: Composition-based stats.
Identities = 259/408 (63%), Positives = 319/408 (78%), Gaps = 3/408 (0%)
Query: 31 RIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQAAE 90
+I+ G+VV+M GDEMTRIIW LIKEKLI P+VD+ + YDLSI +RDA+ND+VT+ AAE
Sbjct: 4 KIQG-GSVVEMQGDEMTRIIWELIKEKLIFPYVDLDLHSYDLSIENRDATNDQVTKDAAE 62
Query: 91 AIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRVVP 150
AI+++NVG+KCATITPDE RV+EF LK+MWKSPNGTIRNILGGTVFRE II KN+PR+V
Sbjct: 63 AIKKYNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVS 122
Query: 151 QWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNFK-GEGVGLAM 208
W +PII+GRHAYGDQY+AT+ + P PG++E+ +TP++G V V NF GV + M
Sbjct: 123 GWVKPIIIGRHAYGDQYRATDFVVPGPGKVEICYTPSDGSPKTVYLVHNFTESGGVAMGM 182
Query: 209 YNTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFERL 268
+N +S+E FA S F+ A+ + +PL LSTKNTILKKYDG F + FQ +YD +Y+ QFE
Sbjct: 183 FNQDKSIEDFAHSSFQMALSKNWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQ 242
Query: 269 NLTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDGKT 328
N+ Y HRLIDD VAQ +K GGF+WACKNYDGDVQSD VAQG+GSLG+MTSVL+CPDGKT
Sbjct: 243 NIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKT 302
Query: 329 IESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLERA 388
+E+EAAHGTVTRHYR +QKG+ETSTN +ASIFAWTRGLAHR KLD N L FA +LE
Sbjct: 303 VEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELSFFAKALEEV 362
Query: 389 TIKTIEGGHMTKDLALCVHGAAALQRSHYETTEVFIDSVAEELARSVK 436
I+TIE G MTKDLA C+ G +QRS Y T F+D + E L +
Sbjct: 363 CIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLQLKLA 410
>ref|NP_698203.1| isocitrate dehydrogenase [Brucella suis 1330]
ref|YP_001593041.1| isocitrate dehydrogenase, NADP-dependent [Brucella canis ATCC
23365]
ref|YP_001627868.1| isocitrate dehydrogenase, NADP-dependent [Brucella suis ATCC 23445]
gb|AAN30118.1| isocitrate dehydrogenase, NADP-dependent [Brucella suis 1330]
gb|ABX62270.1| isocitrate dehydrogenase, NADP-dependent [Brucella canis ATCC
23365]
gb|ABY38298.1| isocitrate dehydrogenase, NADP-dependent [Brucella suis ATCC 23445]
Length = 404
Score = 713 bits (1840), Expect = 0.0, Method: Composition-based stats.
Identities = 247/410 (60%), Positives = 312/410 (76%), Gaps = 7/410 (1%)
Query: 29 LGRIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQA 88
+ +IKV+ VV++DGDEMTRIIW IK+KLI P++D+ ++YYDLS+ +RDA+ND+VT A
Sbjct: 1 MAKIKVANPVVELDGDEMTRIIWQFIKDKLIHPYLDIDLKYYDLSVENRDATNDQVTIDA 60
Query: 89 AEAIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRV 148
A AI+ + VG+KCATITPDEARV+EF LKKMWKSPNGTIRNILGG +FREPII KNVPR+
Sbjct: 61 ANAIKEYGVGVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGVIFREPIICKNVPRL 120
Query: 149 VPQWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNFKGEGVGLA 207
VP W++PIIVGRHA+GDQY+AT+ FP G L + +G EV+ GV +A
Sbjct: 121 VPGWTQPIIVGRHAFGDQYRATDFKFPGKGTLTIKFVGEDG-QTIEHEVYQAPSAGVAMA 179
Query: 208 MYNTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFER 267
MYN ES+ FA + F Y + R YP+ LSTKNTILK YDG F + FQ ++D +++ +FE
Sbjct: 180 MYNLDESIREFARASFNYGLQRGYPVYLSTKNTILKAYDGRFKDIFQEVFDAEFKSKFEE 239
Query: 268 LNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDGK 327
+ Y HRLIDD VA +K +GG+VWACKNYDGDVQSDIVAQGFGSLGLMTSVL+ PDGK
Sbjct: 240 KKIWYEHRLIDDMVASALKWSGGYVWACKNYDGDVQSDIVAQGFGSLGLMTSVLMTPDGK 299
Query: 328 TIESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLER 387
T+E+EAAHGTVTRHYR++QKG+ETSTNS+ASIFAWTRGLAHR KLD NA L +FA +LE+
Sbjct: 300 TVEAEAAHGTVTRHYRQYQKGEETSTNSIASIFAWTRGLAHRAKLDNNADLKKFAETLEK 359
Query: 388 ATIKTIEGGHMTKDLALCVHGAAALQRSHYETTEVFIDSVAEELARSVKG 437
+ T+E G MTKDLAL + + +T F+D + E L +++
Sbjct: 360 VCVDTVESGFMTKDLALLIG-----PDQPWLSTTGFLDKIDENLQKAMAA 404
>emb|CAA53300.1| isocitrate dehydrogenase (NADP+) [Solanum tuberosum]
Length = 438
Score = 713 bits (1840), Expect = 0.0, Method: Composition-based stats.
Identities = 254/417 (60%), Positives = 317/417 (76%), Gaps = 2/417 (0%)
Query: 21 FVSTTRPSLGRIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDAS 80
F+S + + +I V +V+MDGDEMTR+IW IK+KLILP +++ I+Y+ L + RDA+
Sbjct: 17 FLSICKMAFQKITVQNPIVEMDGDEMTRVIWKSIKDKLILPFLELDIKYFSLGLPHRDAT 76
Query: 81 NDKVTEQAAEAIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPI 140
+DKVT ++AEA Q++NV IKCATITPDEARVKEFNLK MW+SPNGTIRNIL GTVFREPI
Sbjct: 77 DDKVTVESAEATQKYNVAIKCATITPDEARVKEFNLKSMWRSPNGTIRNILNGTVFREPI 136
Query: 141 IVKNVPRVVPQWSEPIIVGRHAYGDQYKATESLF-PPGRLELVHTPANGGSPQVLEVFNF 199
+ KN+PR+VP W++PI +GRHA+GDQY+AT+++ G+L+LV P EV+NF
Sbjct: 137 MCKNIPRLVPGWTKPICIGRHAFGDQYRATDTVIKGAGKLKLVFVPEGSDEKTEFEVYNF 196
Query: 200 KG-EGVGLAMYNTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYD 258
G GV L+MYNT ESV +FAE+ A +++PL LSTKNTILKKYDG F + FQ +Y+
Sbjct: 197 TGAGGVALSMYNTDESVRSFAEASMNMAFQKKWPLYLSTKNTILKKYDGRFKDIFQEVYE 256
Query: 259 TKYREQFERLNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMT 318
++ ++E + Y HRLIDD VA +K GG+VWACKNYDGDVQSD +AQGFGSLGLMT
Sbjct: 257 ANWKSKYEEAGIWYEHRLIDDMVAYALKSEGGYVWACKNYDGDVQSDFLAQGFGSLGLMT 316
Query: 319 SVLLCPDGKTIESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPL 378
SVL+CPDGKTIE+EAAHGTVTRHYR HQKG ETSTNS+ASIFAWTRGLAHR LD N L
Sbjct: 317 SVLVCPDGKTIEAEAAHGTVTRHYRVHQKGGETSTNSIASIFAWTRGLAHRATLDNNERL 376
Query: 379 VEFASSLERATIKTIEGGHMTKDLALCVHGAAALQRSHYETTEVFIDSVAEELARSV 435
++F LE A I +E G MTKDLAL + + L R HY TE FID+VA+EL +
Sbjct: 377 LDFTEKLEAACIGAVESGKMTKDLALIIIHGSKLSREHYLNTEEFIDAVADELKARL 433
>gb|ABF20272.1| mitochondrial isocitrate dehydrogenase [Leishmania tropica]
Length = 435
Score = 713 bits (1840), Expect = 0.0, Method: Composition-based stats.
Identities = 322/437 (73%), Positives = 382/437 (87%), Gaps = 2/437 (0%)
Query: 1 MFRRVACAASSVNAGALTPRFVSTTRPSLGRIKVSGTVVDMDGDEMTRIIWALIKEKLIL 60
MFR+V+ A++S + F ST RIKV VVDMDGDEMTRIIW+ IKEKLIL
Sbjct: 1 MFRQVSAASAS--SLVTARSFSSTNVYLDKRIKVKNEVVDMDGDEMTRIIWSFIKEKLIL 58
Query: 61 PHVDVPIEYYDLSITSRDASNDKVTEQAAEAIQRHNVGIKCATITPDEARVKEFNLKKMW 120
P+VDVPI Y+DLS+T+RDA+NDKVT +AAEAI++ NVGIKCATITPDEARVKEFNLKKMW
Sbjct: 59 PYVDVPINYFDLSVTNRDATNDKVTVEAAEAIKKCNVGIKCATITPDEARVKEFNLKKMW 118
Query: 121 KSPNGTIRNILGGTVFREPIIVKNVPRVVPQWSEPIIVGRHAYGDQYKATESLFPPGRLE 180
KSPNGTIRNILGGTVFREPIIV N+PR+VPQW PI+VGRHA+GDQYKAT+++ PG+L+
Sbjct: 119 KSPNGTIRNILGGTVFREPIIVSNIPRIVPQWHNPIVVGRHAFGDQYKATDAVLKPGKLQ 178
Query: 181 LVHTPANGGSPQVLEVFNFKGEGVGLAMYNTRESVEAFAESCFEYAIMRRYPLVLSTKNT 240
LVHTPA+G +P L+V++FKG+GVGLAMYNT+ES+E FA+SCF+YA+MR+YPLVL+TKNT
Sbjct: 179 LVHTPADGSAPTTLDVYDFKGDGVGLAMYNTKESIEGFAKSCFQYALMRKYPLVLTTKNT 238
Query: 241 ILKKYDGLFLETFQRMYDTKYREQFERLNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDG 300
ILKKYDG+FL+TFQRMYD +Y+ FE+ +TY HRLIDDQVAQMIKG GGFVWACKNYDG
Sbjct: 239 ILKKYDGMFLQTFQRMYDEQYKADFEKAGITYNHRLIDDQVAQMIKGEGGFVWACKNYDG 298
Query: 301 DVQSDIVAQGFGSLGLMTSVLLCPDGKTIESEAAHGTVTRHYREHQKGKETSTNSVASIF 360
DVQSDIVAQGFGSLGLMTSVL+CPDGKTIE+EAAHGTVTRHYR+HQ+GKETSTNSVASI+
Sbjct: 299 DVQSDIVAQGFGSLGLMTSVLMCPDGKTIEAEAAHGTVTRHYRQHQQGKETSTNSVASIY 358
Query: 361 AWTRGLAHRGKLDGNAPLVEFASSLERATIKTIEGGHMTKDLALCVHGAAALQRSHYETT 420
AWTRGLAHRGKLDGN+ LV F+ +LER +K IE GHMTKDLALCV+G++ ++R HYETT
Sbjct: 359 AWTRGLAHRGKLDGNSDLVRFSETLERVVVKAIEDGHMTKDLALCVYGSSGVKREHYETT 418
Query: 421 EVFIDSVAEELARSVKG 437
E F+DSV L +++
Sbjct: 419 EQFLDSVDAALKKAMSA 435
>gb|AAH93020.1| Isocitrate dehydrogenase 1 (NADP+), soluble [Homo sapiens]
Length = 414
Score = 712 bits (1839), Expect = 0.0, Method: Composition-based stats.
Identities = 256/410 (62%), Positives = 319/410 (77%), Gaps = 2/410 (0%)
Query: 29 LGRIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTEQA 88
+ + G+VV+M GDEMTRIIW LIKEKLI P+V++ + YDL I +RDA+ND+VT+ A
Sbjct: 1 MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDA 60
Query: 89 AEAIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRV 148
AEAI++HNVG+KCATITPDE RV+EF LK+MWKSPNGTIRNILGGTVFRE II KN+PR+
Sbjct: 61 AEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 149 VPQWSEPIIVGRHAYGDQYKATESLFP-PGRLELVHTPANGGSPQVLEVFNFK-GEGVGL 206
V W +PII+GRHAYGDQY+AT+ + P PG++E+ +TP++G V NF+ G GV +
Sbjct: 121 VSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAM 180
Query: 207 AMYNTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKYREQFE 266
MYN +S+E FA S F+ A+ + +PL LSTKNTILKKYDG F + FQ +YD +Y+ QFE
Sbjct: 181 GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE 240
Query: 267 RLNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLLCPDG 326
+ Y HRLIDD VAQ +K GGF+WACKNYDGDVQSD VAQG+GSLG+MTSVL+CPDG
Sbjct: 241 AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG 300
Query: 327 KTIESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEFASSLE 386
KT+E+E+AHGTVTRHYR +QKG+ETSTN +ASIFAWTRGLAHR KLD N L FA++LE
Sbjct: 301 KTVEAESAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALE 360
Query: 387 RATIKTIEGGHMTKDLALCVHGAAALQRSHYETTEVFIDSVAEELARSVK 436
+I+TIE G MTKDLA C+ G +QRS Y T F+D + E L +
Sbjct: 361 EVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLA 410
Database: All non-redundant GenBank CDS
translations+PDB+SwissProt+PIR+PRF excluding environmental samples
from WGS projects
Posted date: May 23, 2008 5:56 PM
Number of letters in database: 883,778,997
Number of sequences in database: 2,617,685
Database: /host/Blast/data/nr_perl/nr.01
Posted date: May 23, 2008 5:54 PM
Number of letters in database: 976,759,346
Number of sequences in database: 2,761,413
Database: /host/Blast/data/nr_perl/nr.02
Posted date: May 23, 2008 5:48 PM
Number of letters in database: 374,670,760
Number of sequences in database: 1,165,270
Database: /host/Blast/data/nr_perl/nr.03
Posted date: Apr 28, 2009 5:40 PM
Number of letters in database: 114,943,120
Number of sequences in database: 354,819
Lambda K H
0.314 0.168 0.495
Lambda K H
0.267 0.0512 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 7,375,410,641
Number of Sequences: 6899187
Number of extensions: 395193030
Number of successful extensions: 903626
Number of sequences better than 10.0: 300
Number of HSP's better than 10.0 without gapping: 6763
Number of HSP's successfully gapped in prelim test: 1905
Number of HSP's that attempted gapping in prelim test: 858431
Number of HSP's gapped (non-prelim): 9600
length of query: 437
length of database: 2,350,152,223
effective HSP length: 137
effective length of query: 300
effective length of database: 1,404,963,604
effective search space: 421489081200
effective search space used: 421489081200
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.1 bits)
S2: 81 (35.5 bits)