BLASTP 2.2.17 [Aug-26-2007]
Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Reference for composition-based statistics:
Schäffer, Alejandro A., L. Aravind, Thomas L. Madden,
Schaffer, Alejandro A., L. Aravind, Thomas L. Madden,
Sergei Shavirin, John L. Spouge, Yuri I. Wolf,
Eugene V. Koonin, and Stephen F. Altschul (2001),
"Improving the accuracy of PSI-BLAST protein database searches with
composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005.
Query= XP_828183__[Trypanosoma_brucei]
(413 letters)
Database: All non-redundant GenBank CDS
translations+PDB+SwissProt+PIR+PRF excluding environmental samples
from WGS projects
6,899,187 sequences; 2,350,152,223 total letters
Searching..................................................done
Results from round 1
Score E
Sequences producing significant alignments: (bits) Value
ref|XP_828183.1| isocitrate dehydrogenase [Trypanosoma bruc... 858 0.0
ref|XP_821599.1| isocitrate dehydrogenase, putative [Trypan... 681 0.0
ref|XP_001650675.1| nadp-specific isocitrate dehydrogenase ... 593 e-168
gb|ACO14957.1| Isocitrate dehydrogenase cytoplasmic [Caligu... 590 e-167
ref|XP_001698704.1| isocitrate dehydrogenase, NADP-dependen... 590 e-167
ref|XP_001841910.1| isocitrate dehydrogenase cytoplasmic [C... 589 e-166
ref|XP_001688948.1| AGAP006660-PA [Anopheles gambiae str. P... 586 e-165
ref|XP_421965.2| PREDICTED: similar to cytosolic NADP-depen... 585 e-165
gb|ABU41004.1| isocitrate dehydrogenase 1 [Anser anser] 585 e-165
emb|CAG38738.1| IDH1 [Homo sapiens] 584 e-165
ref|NP_001009276.1| cytosolic NADP-isocitrate dehydrogenase... 583 e-165
ref|XP_860821.1| PREDICTED: similar to Isocitrate dehydroge... 583 e-165
ref|XP_001511049.1| PREDICTED: similar to cytosolic NADP-de... 583 e-165
ref|XP_001107627.1| PREDICTED: isocitrate dehydrogenase 1 (... 583 e-164
ref|NP_005887.2| isocitrate dehydrogenase 1 (NADP+), solubl... 582 e-164
ref|NP_851355.2| isocitrate dehydrogenase 1 (NADP+), solubl... 582 e-164
gb|AAH93020.1| Isocitrate dehydrogenase 1 (NADP+), soluble ... 582 e-164
emb|CAD97653.1| hypothetical protein [Homo sapiens] >gi|117... 581 e-164
ref|XP_001505172.1| PREDICTED: similar to Isocitrate dehydr... 581 e-164
ref|NP_001088022.1| hypothetical protein LOC494713 [Xenopus... 581 e-164
sp|Q9XSG3|IDHC_BOVIN Isocitrate dehydrogenase [NADP] cytopl... 580 e-164
ref|XP_850187.1| PREDICTED: similar to Isocitrate dehydroge... 580 e-164
ref|NP_958907.1| isocitrate dehydrogenase 1 (NADP+), solubl... 580 e-163
ref|XP_001141655.1| PREDICTED: isocitrate dehydrogenase 1 (... 579 e-163
emb|CAQ15240.1| isocitrate dehydrogenase 1 (NADP+), soluble... 579 e-163
ref|XP_001176537.1| PREDICTED: similar to Isocitrate dehydr... 579 e-163
emb|CAH89719.1| hypothetical protein [Pongo abelii] 578 e-163
sp|Q5R9C5|IDHC_PONPY Isocitrate dehydrogenase [NADP] cytopl... 578 e-163
emb|CAB66637.1| hypothetical protein [Homo sapiens] >gi|117... 578 e-163
emb|CAG02627.1| unnamed protein product [Tetraodon nigrovir... 578 e-163
ref|NP_113698.1| isocitrate dehydrogenase 1 (NADP+), solubl... 578 e-163
sp|O88844|IDHC_MOUSE Isocitrate dehydrogenase [NADP] cytopl... 578 e-163
sp|Q9Z2K9|IDHC_MICME Isocitrate dehydrogenase [NADP] cytopl... 577 e-163
gb|AAD02918.1| NADP-dependent isocitrate dehydrogenase [Hom... 577 e-163
pdb|2CMJ|A Chain A, Crystal Structure Of Mouse Cytosolic Is... 577 e-163
ref|NP_034627.3| isocitrate dehydrogenase 1 (NADP+), solubl... 577 e-163
dbj|BAE39644.1| unnamed protein product [Mus musculus] 577 e-163
ref|XP_001633903.1| predicted protein [Nematostella vectens... 576 e-163
emb|CAG38553.1| IDH1 [Homo sapiens] 576 e-163
dbj|BAC39792.1| unnamed protein product [Mus musculus] 576 e-162
gb|AAH88986.1| Isocitrate dehydrogenase 1 (NADP+), soluble ... 576 e-162
sp|Q9Z2K8|IDHC_MICOH Isocitrate dehydrogenase [NADP] cytopl... 576 e-162
ref|XP_780121.1| PREDICTED: similar to cytosolic NADP-depen... 575 e-162
ref|XP_860853.1| PREDICTED: similar to Isocitrate dehydroge... 575 e-162
emb|CAH91635.1| hypothetical protein [Pongo abelii] 574 e-162
gb|AAV33246.1| isocitrate dehydrogenase [Toxoplasma gondii] 573 e-161
ref|XP_001365492.1| PREDICTED: similar to cytosolic NADP-de... 572 e-161
ref|YP_872148.1| isocitrate dehydrogenase [Acidothermus cel... 571 e-161
ref|XP_968850.1| PREDICTED: similar to CG7176-PC, isoform C... 570 e-161
gb|ABO93633.1| isocitrate dehydrogenase 2 [Toxoplasma gondii] 570 e-161
ref|NP_001040134.1| isocitrate dehydrogenase [Bombyx mori] ... 570 e-161
ref|YP_062774.1| isocitrate dehydrogenase [Leifsonia xyli s... 569 e-160
ref|NP_970434.1| isocitrate dehydrogenase [Bdellovibrio bac... 568 e-160
dbj|BAC77065.1| NADP-specific isocitrate dehydrogenase [Lup... 568 e-160
gb|ABI52605.1| isocitrate dehydrogenase [Gryllus firmus] 567 e-160
sp|Q40345|IDHP_MEDSA Isocitrate dehydrogenase [NADP], chlor... 566 e-160
ref|NP_217856.1| isocitrate dehydrogenase [Mycobacterium tu... 566 e-159
ref|NP_786984.1| isocitrate dehydrogenase 2 (NADP+), mitoch... 566 e-159
sp|Q04467|IDHP_BOVIN Isocitrate dehydrogenase [NADP], mitoc... 566 e-159
gb|EAY58582.1| isocitrate dehydrogenase [NADP] icd1 [Mycoba... 566 e-159
ref|YP_001709366.1| isocitrate dehydrogenase [Clavibacter m... 566 e-159
ref|YP_001223282.1| isocitrate dehydrogenase [Clavibacter m... 566 e-159
ref|XP_536192.2| PREDICTED: similar to isocitrate dehydroge... 566 e-159
emb|CAA53300.1| isocitrate dehydrogenase (NADP+) [Solanum t... 565 e-159
ref|NP_001026770.1| hypothetical protein LOC431056 [Gallus ... 565 e-159
ref|XP_001020930.2| dehydrogenase, isocitrate/isopropylmala... 565 e-159
ref|YP_979491.1| isocitrate dehydrogenase [Mycobacterium bo... 565 e-159
sp|P54071|IDHP_MOUSE Isocitrate dehydrogenase [NADP], mitoc... 565 e-159
ref|XP_001778805.1| predicted protein [Physcomitrella paten... 565 e-159
ref|NP_766599.1| isocitrate dehydrogenase 2 (NADP+), mitoch... 565 e-159
ref|XP_001369305.1| PREDICTED: hypothetical protein [Monode... 565 e-159
dbj|BAD96636.1| isocitrate dehydrogenase 2 (NADP+), mitocho... 564 e-159
gb|AAS49171.1| NADP-dependent isocitrate dehydrogenase [Pis... 564 e-159
pdb|1LWD|A Chain A, Crystal Structure Of Nadp-Dependent Iso... 564 e-159
sp|P33198|IDHP_PIG Isocitrate dehydrogenase [NADP], mitocho... 563 e-159
gb|ABE98244.1| mitochondrial isocitrate dehydrogenase 2-lik... 563 e-159
ref|NP_175836.1| ICDH; isocitrate dehydrogenase (NADP+) [Ar... 563 e-158
gb|AAC64182.1| NADP-dependent isocitrate dehydrogenase [Gly... 563 e-158
ref|YP_001849499.1| isocitrate dehydrogenase [NADP] Icd1 [M... 562 e-158
ref|NP_002159.2| isocitrate dehydrogenase 2 (NADP+), mitoch... 562 e-158
sp|P50217|IDHC_SOLTU Isocitrate dehydrogenase [NADP] (Oxalo... 562 e-158
gb|EAX02083.1| isocitrate dehydrogenase 2 (NADP+), mitochon... 562 e-158
ref|XP_510589.2| PREDICTED: isocitrate dehydrogenase 2 (NAD... 562 e-158
emb|CAA49208.1| isocitrate dehydrogenase (NADP+) [Homo sapi... 562 e-158
ref|YP_425448.1| isocitrate dehydrogenase [Rhodospirillum r... 561 e-158
dbj|BAA34113.1| NADP specific isocitrate dehydrogenase [Dau... 561 e-158
ref|XP_001095686.1| PREDICTED: isocitrate dehydrogenase 2 (... 561 e-158
ref|NP_001014183.1| isocitrate dehydrogenase 2 (NADP+), mit... 561 e-158
ref|XP_001670101.1| Hypothetical protein CBG21657 [Caenorha... 561 e-158
ref|NP_196963.2| isocitrate dehydrogenase, putative / NADP+... 561 e-158
ref|XP_001168316.1| PREDICTED: isocitrate dehydrogenase 2 (... 560 e-158
ref|XP_001778590.1| predicted protein [Physcomitrella paten... 560 e-158
ref|NP_001056381.1| Os05g0573200 [Oryza sativa (japonica cu... 560 e-158
gb|AAA33978.1| NADPH-specific isocitrate dehydrogenase 560 e-158
sp|P50218|IDHC_TOBAC Isocitrate dehydrogenase [NADP] (Oxalo... 560 e-158
ref|XP_001462393.1| hypothetical protein GSPATT00027349001 ... 560 e-157
ref|ZP_03922528.1| isocitrate dehydrogenase [Mobiluncus cur... 559 e-157
pir||S33612 isocitrate dehydrogenase (NADP) (EC 1.1.1.42) -... 559 e-157
ref|NP_501665.1| F59B8.2 [Caenorhabditis elegans] >gi|38778... 559 e-157
ref|NP_955858.1| isocitrate dehydrogenase 2 (NADP+), mitoch... 559 e-157
ref|XP_001454244.1| hypothetical protein GSPATT00020509001 ... 559 e-157
gb|ACO14046.1| Isocitrate dehydrogenase, mitochondrial prec... 559 e-157
ref|NP_001043749.1| Os01g0654500 [Oryza sativa (japonica cu... 558 e-157
ref|NP_001053269.1| Os04g0508200 [Oryza sativa (japonica cu... 558 e-157
emb|CAG13105.1| unnamed protein product [Tetraodon nigrovir... 558 e-157
ref|YP_001296741.1| isocitrate dehydrogenase [Flavobacteriu... 558 e-157
gb|AAL11503.1|AF367443_1 NADP-dependent isocitrate dehydrog... 558 e-157
ref|YP_001538953.1| isocitrate dehydrogenase, NADP-dependen... 558 e-157
ref|YP_001160602.1| isocitrate dehydrogenase [Salinispora t... 558 e-157
ref|YP_756242.1| isocitrate dehydrogenase [Maricaulis maris... 558 e-157
sp|Q06197|IDHC_SOYBN Isocitrate dehydrogenase [NADP] (Oxalo... 557 e-157
gb|AAR05796.1| NADP+-isocitrate dehydrogenase [Pinus pinaster] 557 e-157
ref|ZP_01885694.1| isocitrate dehydrogenase [Pedobacter sp.... 557 e-157
emb|CAD24779.1| isocitrate dehydrogenase [Cucumis sativus] 557 e-157
ref|YP_883449.1| isocitrate dehydrogenase [Mycobacterium av... 557 e-157
ref|NP_962389.1| isocitrate dehydrogenase [Mycobacterium av... 556 e-156
ref|ZP_03891012.1| isocitrate dehydrogenase (NADP) [Geoderm... 556 e-156
emb|CAH67563.1| OSIGBa0101P20.6 [Oryza sativa (indica culti... 556 e-156
gb|AAD51361.1|AF176669_1 NADP-isocitrate dehydrogenase [Cit... 556 e-156
emb|CAE04728.1| OSJNBa0043L24.16 [Oryza sativa (japonica cu... 556 e-156
dbj|BAC77063.1| NADP-specific isocitrate dehydrogenase [Lup... 556 e-156
ref|YP_001413846.1| isocitrate dehydrogenase, NADP-dependen... 556 e-156
ref|XP_623673.2| PREDICTED: similar to Isocitrate dehydroge... 555 e-156
emb|CAA73139.1| isocitrate dehydrogenase (NADP+) [Apium gra... 555 e-156
ref|ZP_02124492.1| Isocitrate dehydrogenase (NADP(+)) [Meth... 554 e-156
ref|YP_677841.1| isocitrate dehydrogenase [Cytophaga hutchi... 554 e-156
ref|ZP_01130474.1| isocitrate dehydrogenase [marine actinob... 554 e-156
dbj|BAA34112.1| NADP specific isocitrate dehydrogenase [Dau... 554 e-156
ref|NP_729366.1| Isocitrate dehydrogenase CG7176-PB, isofor... 554 e-156
dbj|BAE48792.1| NADP-isocitrate dehydrogenase [Codonopsis l... 554 e-156
ref|NP_729367.1| Isocitrate dehydrogenase CG7176-PD, isofor... 554 e-156
gb|AAB39248.1| NADP-isocitrate dehydrogenase [Eucalyptus gl... 554 e-156
ref|XP_001845030.1| isocitrate dehydrogenase [Culex pipiens... 553 e-156
emb|CAG02362.1| unnamed protein product [Tetraodon nigrovir... 553 e-156
gb|ABK24873.1| unknown [Picea sitchensis] 553 e-156
ref|NP_729368.1| Isocitrate dehydrogenase CG7176-PA, isofor... 553 e-156
ref|NP_652044.1| Isocitrate dehydrogenase CG7176-PC, isofor... 553 e-156
ref|XP_001426548.1| hypothetical protein GSPATT00029781001 ... 553 e-155
ref|XP_645283.1| isocitrate dehydrogenase (NADP+) [Dictyost... 553 e-155
ref|XP_001608101.1| PREDICTED: similar to isocitrate dehydr... 553 e-155
gb|EDT29808.1| isocitrate dehydrogenase, NADP-dependent [Ol... 552 e-155
ref|NP_001080321.1| hypothetical protein LOC380013 [Xenopus... 552 e-155
dbj|BAC77064.1| NADP-specific isocitrate dehydrogenase [Lup... 552 e-155
gb|ABK25438.1| unknown [Picea sitchensis] 552 e-155
gb|ABF20244.1| mitochondrial isocitrate dehydrogenase [Leis... 552 e-155
emb|CAA65503.1| isocitrate dehydrogenase (NADP+) [Nicotiana... 552 e-155
gb|ABF20272.1| mitochondrial isocitrate dehydrogenase [Leis... 552 e-155
ref|XP_001463680.1| isocitrate dehydrogenase [NADP], mitoch... 552 e-155
emb|CAA65504.1| isocitrate dehydrogenase (NADP+) [Nicotiana... 551 e-155
ref|XP_001457045.1| hypothetical protein GSPATT00022820001 ... 551 e-155
ref|YP_419971.1| isocitrate dehydrogenase [Magnetospirillum... 551 e-155
ref|XP_001681361.1| isocitrate dehydrogenase [NADP], mitoch... 551 e-155
emb|CAB87626.1| isocitrate dehydrogenase-like protein [Arab... 551 e-155
gb|ABA18651.1| cytosolic NADP+-isocitrate dehydrogenase [Po... 551 e-155
ref|XP_970446.1| PREDICTED: similar to isocitrate dehydroge... 551 e-155
ref|YP_117132.1| isocitrate dehydrogenase [Nocardia farcini... 551 e-155
emb|CAA63220.1| isocitrate dehydrogenase (NAD+) [Solanum tu... 551 e-155
ref|XP_001168291.1| PREDICTED: isocitrate dehydrogenase 2 (... 551 e-155
ref|ZP_00952302.1| isocitrate dehydrogenase [Oceanicaulis a... 550 e-155
ref|YP_001769504.1| isocitrate dehydrogenase, NADP-dependen... 550 e-155
emb|CAM77136.1| Isocitrate/isopropylmalate dehydrogenase [M... 550 e-155
ref|YP_001623415.1| isocitrate dehydrogenase (NADP) [Reniba... 550 e-155
ref|NP_001004799.1| MGC69505 protein [Xenopus tropicalis] >... 550 e-155
gb|ABF20271.1| mitochondrial isocitrate dehydrogenase [Leis... 549 e-154
ref|YP_290624.1| isocitrate dehydrogenase [Thermobifida fus... 548 e-154
ref|ZP_02188085.1| Isocitrate dehydrogenase [alpha proteoba... 548 e-154
ref|XP_001634205.1| predicted protein [Nematostella vectens... 548 e-154
gb|EAY99113.1| hypothetical protein OsI_020346 [Oryza sativ... 548 e-154
ref|YP_001832264.1| isocitrate dehydrogenase, NADP-dependen... 548 e-154
ref|NP_176768.1| isocitrate dehydrogenase, putative / NADP+... 547 e-154
ref|ZP_00056387.1| COG0538: Isocitrate dehydrogenases [Magn... 547 e-154
emb|CAO64975.1| unnamed protein product [Vitis vinifera] 547 e-154
emb|CAN72808.1| hypothetical protein [Vitis vinifera] >gi|1... 546 e-154
ref|XP_847200.1| isocitrate dehydrogenase [NADP], mitochond... 546 e-154
ref|XP_001168261.1| PREDICTED: isocitrate dehydrogenase 2 (... 546 e-153
ref|YP_002826161.1| NADP isocitrate dehydrogenase [Rhizobiu... 546 e-153
gb|AAC52473.1| isocitrate dehydrogenase 546 e-153
gb|AAM13090.1| similar to NADP-specific isocitrate dehydrog... 545 e-153
ref|NP_509875.1| C34F6.8 [Caenorhabditis elegans] >gi|38747... 545 e-153
emb|CAD24782.1| isocitrate dehydrogenase [Arabidopsis thali... 545 e-153
ref|XP_001676039.1| Hypothetical protein CBG17397 [Caenorha... 545 e-153
ref|XP_001562802.1| isocitrate dehydrogenase [NADP], mitoch... 545 e-153
ref|XP_312860.4| AGAP003168-PA [Anopheles gambiae str. PEST... 545 e-153
ref|ZP_03869030.1| isocitrate dehydrogenase (NADP) [Jonesia... 545 e-153
prf||2211361A isocitrate dehydrogenase 545 e-153
ref|XP_001354101.1| GA20156-PA [Drosophila pseudoobscura] >... 544 e-153
gb|AAI53922.1| Idh1 protein [Danio rerio] 544 e-153
gb|ABD77209.1| isocitrate dehydrogenase 1 [Rattus norvegicus] 544 e-153
gb|ABD77208.1| isocitrate dehydrogenase 1 [Mus musculus] 544 e-153
ref|YP_001833636.1| isocitrate dehydrogenase, NADP-dependen... 543 e-153
ref|YP_706173.1| isocitrate dehydrogenase [Rhodococcus sp. ... 543 e-152
gb|AAM65674.1| isocitrate dehydrogenase, putative [Arabidop... 543 e-152
gb|EEJ98364.1| isocitrate dehydrogenase (NADP) [Thermomonos... 542 e-152
ref|XP_001528456.1| isocitrate dehydrogenase, mitochondrial... 542 e-152
ref|YP_002761841.1| NADP-dependent isocitrate dehydrogenase... 542 e-152
gb|ABD77215.1| isocitrate dehydrogenase 1 [Homo sapiens] 541 e-152
ref|NP_926944.1| isocitrate dehydrogenase [Gloeobacter viol... 541 e-152
ref|YP_001685152.1| isocitrate dehydrogenase, NADP-dependen... 541 e-152
ref|NP_354851.2| isocitrate dehydrogenase [Agrobacterium tu... 541 e-152
gb|ABD77216.1| isocitrate dehydrogenase 1 [Aotus trivirgatus] 541 e-152
ref|XP_001017274.1| isocitrate dehydrogenase, NADP-dependen... 540 e-152
ref|ZP_03993927.1| isocitrate dehydrogenase [Mobiluncus mul... 540 e-152
gb|AAT06312.1| isocitrate dehydrogenase [Rhizobium legumino... 540 e-152
ref|YP_002765452.1| NADP-dependent isocitrate dehydrogenase... 540 e-151
ref|ZP_02166681.1| isocitrate dehydrogenase [Hoeflea photot... 540 e-151
ref|YP_768215.1| isocitrate dehydrogenase [Rhizobium legumi... 540 e-151
ref|ZP_02858718.1| isocitrate dehydrogenase, NADP-dependent... 540 e-151
ref|NP_001093090.1| NADPH-specific isocitrate dehydrogenase... 539 e-151
ref|YP_001758392.1| isocitrate dehydrogenase, NADP-dependen... 539 e-151
ref|NP_421325.1| isocitrate dehydrogenase [Caulobacter cres... 539 e-151
ref|ZP_02955422.1| isocitrate dehydrogenase, NADP-dependent... 539 e-151
ref|NP_001042583.1| Os01g0248400 [Oryza sativa (japonica cu... 538 e-151
ref|ZP_02295934.1| isocitrate dehydrogenase, NADP-dependent... 538 e-151
ref|XP_813368.1| isocitrate dehydrogenase [NADP], mitochond... 538 e-151
ref|XP_001384028.1| Isocitrate dehydrogenase [NADP], mitoch... 538 e-151
ref|ZP_01018081.1| isocitrate dehydrogenase [Parvularcula b... 538 e-151
gb|ABL97438.1| isocitrate dehydrogenase [uncultured marine ... 538 e-151
ref|XP_645284.1| isocitrate dehydrogenase (NADP+) [Dictyost... 538 e-151
ref|ZP_01228834.1| NADP dependent isocitrate dehydrogenase ... 538 e-151
ref|XP_710919.1| NADP-specific isocitrate dehydrogenase [Ca... 538 e-151
ref|YP_487337.1| isocitrate dehydrogenase [Rhodopseudomonas... 538 e-151
ref|ZP_03813993.1| isocitrate dehydrogenase (NADP) [Beutenb... 537 e-151
ref|XP_001878769.1| predicted protein [Laccaria bicolor S23... 537 e-151
ref|XP_001837820.1| hypothetical protein CC1G_11465 [Coprin... 537 e-151
ref|YP_001524781.1| NADP-dependent isocitrate dehydrogenase... 537 e-151
ref|ZP_03896321.1| isocitrate dehydrogenase (NADP) [Dyadoba... 537 e-151
gb|ABD77211.1| isocitrate dehydrogenase 1 [Cavia porcellus] 537 e-151
ref|ZP_00206729.1| COG0538: Isocitrate dehydrogenases [Bifi... 537 e-151
ref|NP_949171.1| isocitrate dehydrogenase [Rhodopseudomonas... 537 e-151
ref|YP_568874.1| isocitrate dehydrogenase [Rhodopseudomonas... 537 e-151
ref|YP_002783489.1| isocitrate dehydrogenase [Rhodococcus o... 537 e-151
gb|ABD77223.1| isocitrate dehydrogenase 1 [Bos taurus] 537 e-151
gb|ABD77214.1| isocitrate dehydrogenase 1 [Tadarida brasili... 536 e-150
ref|NP_698203.1| isocitrate dehydrogenase [Brucella suis 13... 536 e-150
ref|ZP_01862723.1| isocitrate dehydrogenase [Erythrobacter ... 536 e-150
ref|NP_696658.1| isocitrate dehydrogenase [Bifidobacterium ... 536 e-150
ref|ZP_01040029.1| isocitrate dehydrogenase [Erythrobacter ... 536 e-150
ref|YP_617009.1| isocitrate dehydrogenase [Sphingopyxis ala... 536 e-150
ref|YP_001609735.1| NADP-dependent isocitrate dehydrogenase... 535 e-150
ref|XP_001350171.1| isocitrate dehydrogenase (NADP), mitoch... 535 e-150
ref|YP_673828.1| isocitrate dehydrogenase [Mesorhizobium sp... 535 e-150
ref|YP_033790.1| isocitrate dehydrogenase [Bartonella hense... 535 e-150
ref|YP_001370537.1| isocitrate dehydrogenase, NADP-dependen... 535 e-150
gb|ABD77225.2| isocitrate dehydrogenase 1 [Hippopotamus amp... 535 e-150
ref|XP_725505.1| isocitrate dehydrogenase, NADP-dependent [... 535 e-150
ref|NP_539708.1| isocitrate dehydrogenase [Brucella meliten... 535 e-150
ref|ZP_01440188.1| Isocitrate/isopropylmalate dehydrogenase... 534 e-150
ref|ZP_03977360.1| isocitrate dehydrogenase (NADP(+)) [Bifi... 534 e-150
ref|YP_909639.1| isocitrate dehydrogenase [Bifidobacterium ... 534 e-150
ref|YP_001419447.1| isocitrate dehydrogenase, NADP-dependen... 534 e-150
ref|XP_451683.1| unnamed protein product [Kluyveromyces lac... 533 e-150
gb|ABD77222.1| isocitrate dehydrogenase 1 [Diceros bicornis] 533 e-150
ref|YP_989041.1| isocitrate dehydrogenase [Bartonella bacil... 533 e-150
gb|ABD77217.1| isocitrate dehydrogenase 1 [Tupaia glis] 533 e-149
ref|ZP_02302766.1| isocitrate dehydrogenase, NADP-dependent... 533 e-149
gb|ABD77206.1| isocitrate dehydrogenase 1 [Dasypus novemcin... 533 e-149
gb|ABD77213.1| isocitrate dehydrogenase 1 [Oryctolagus cuni... 532 e-149
gb|ABD77205.1| isocitrate dehydrogenase 1 [Loxodonta africana] 532 e-149
ref|ZP_02963068.1| isocitrate dehydrogenase [Bifidobacteriu... 532 e-149
ref|XP_001484278.1| isocitrate dehydrogenase, mitochondrial... 532 e-149
sp|P50215|IDH_SPHYA Isocitrate dehydrogenase [NADP] (Oxalos... 531 e-149
ref|XP_459772.1| hypothetical protein DEHA0E11286g [Debaryo... 531 e-149
ref|YP_032403.1| isocitrate dehydrogenase [Bartonella quint... 531 e-149
sp|O13285|IDH1_CANTR Isocitrate dehydrogenase [NADP], mitoc... 531 e-149
gb|ABD77224.1| isocitrate dehydrogenase 1 [Balaenoptera phy... 531 e-149
gb|ABD77218.1| isocitrate dehydrogenase 1 [Felis catus] 530 e-149
gb|ABD77210.1| isocitrate dehydrogenase 1 [Mesocricetus aur... 530 e-149
ref|YP_531457.1| isocitrate dehydrogenase [Rhodopseudomonas... 530 e-148
ref|YP_458429.1| isocitrate dehydrogenase [Erythrobacter li... 530 e-148
ref|YP_682929.1| isocitrate dehydrogenase [Roseobacter deni... 530 e-148
ref|XP_001614236.1| isocitrate dehydrogenase [NADP], mitoch... 529 e-148
gb|ABD77221.1| isocitrate dehydrogenase 1 [Ceratotherium si... 529 e-148
ref|XP_569234.1| isocitrate dehydrogenase (NADP+) [Cryptoco... 529 e-148
ref|YP_001363715.1| isocitrate dehydrogenase, NADP-dependen... 529 e-148
ref|XP_569233.1| isocitrate dehydrogenase (NADP+) [Cryptoco... 529 e-148
ref|NP_772387.1| isocitrate dehydrogenase [Bradyrhizobium j... 528 e-148
ref|XP_679587.1| isocitrate dehydrogenase (NADP), mitochond... 528 e-148
ref|NP_101923.1| isocitrate dehydrogenase [Mesorhizobium lo... 528 e-148
ref|XP_001646579.1| hypothetical protein Kpol_1055p78 [Vand... 528 e-148
ref|ZP_02918686.1| hypothetical protein BIFDEN_01996 [Bifid... 528 e-148
gb|ABD36135.1| isocitrate dehydrogenase precursor [Bombyx m... 527 e-148
ref|NP_385898.1| isocitrate dehydrogenase [Sinorhizobium me... 527 e-148
ref|YP_317907.1| isocitrate dehydrogenase [Nitrobacter wino... 527 e-148
ref|NP_984921.1| AER061Cp [Ashbya gossypii ATCC 10895] >gi|... 526 e-148
gb|ABD77207.1| isocitrate dehydrogenase 1 [Tamandua tetrada... 526 e-148
gb|AAF73472.1|AF268076_1 NADP-dependent isocitrate dehydrog... 526 e-148
ref|YP_001327198.1| isocitrate dehydrogenase [Sinorhizobium... 526 e-147
gb|ABD77219.1| isocitrate dehydrogenase 1 [Canis familiaris] 525 e-147
ref|ZP_01046178.1| isocitrate dehydrogenase NADP-dependent ... 525 e-147
ref|YP_001233708.1| isocitrate dehydrogenase [Acidiphilium ... 525 e-147
ref|YP_576902.1| isocitrate dehydrogenase [Nitrobacter hamb... 525 e-147
ref|YP_780531.1| isocitrate dehydrogenase [Rhodopseudomonas... 525 e-147
ref|ZP_01546031.1| isocitrate dehydrogenase [Stappia aggreg... 524 e-147
ref|NP_010217.1| Mitochondrial NADP-specific isocitrate deh... 523 e-147
ref|YP_001204807.1| isocitrate dehydrogenase [Bradyrhizobiu... 523 e-146
gb|AAC50455.1| isocitrate dehydrogenase 522 e-146
ref|YP_496560.1| isocitrate dehydrogenase [Novosphingobium ... 521 e-146
ref|XP_754749.1| isocitrate dehydrogenase Idp1 [Aspergillus... 521 e-146
gb|EDP52872.1| isocitrate dehydrogenase Idp1, putative [Asp... 521 e-146
gb|AAT44354.1| isocitrate dehydrogenase [Crassostrea gigas] 521 e-146
>ref|XP_828183.1| isocitrate dehydrogenase [Trypanosoma brucei TREU927]
gb|EAN79071.1| isocitrate dehydrogenase, putative [Trypanosoma brucei]
Length = 413
Score = 858 bits (2216), Expect = 0.0, Method: Composition-based stats.
Identities = 413/413 (100%), Positives = 413/413 (100%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA
Sbjct: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL
Sbjct: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGGVMMG 180
VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGGVMMG
Sbjct: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGGVMMG 180
Query: 181 MYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKT 240
MYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKT
Sbjct: 181 MYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKT 240
Query: 241 CGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGK 300
CGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGK
Sbjct: 241 CGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGK 300
Query: 301 TVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLED 360
TVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLED
Sbjct: 301 TVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLED 360
Query: 361 VIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
VIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV
Sbjct: 361 VIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
>ref|XP_821599.1| isocitrate dehydrogenase, putative [Trypanosoma cruzi strain CL
Brener]
gb|EAN99748.1| isocitrate dehydrogenase, putative [Trypanosoma cruzi]
Length = 413
Score = 681 bits (1756), Expect = 0.0, Method: Composition-based stats.
Identities = 311/413 (75%), Positives = 364/413 (88%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M KI G +VELDGDEMTRVIWK IKE LIFPF++VPIEYYDL MENRDKT+D+VTV+A
Sbjct: 1 MQKIKVAGTVVELDGDEMTRVIWKMIKEELIFPFLDVPIEYYDLGMENRDKTDDQVTVDA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A+AIKKHGVGVKCATITPDEARV+EFNLK+MW+SPNGTIR ILGGTVFREPI+C NVPRL
Sbjct: 61 AHAIKKHGVGVKCATITPDEARVREFNLKQMWKSPNGTIRNILGGTVFREPIMCKNVPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGGVMMG 180
VTTWK P+VIGRHAFGDQY ATD VV PGTFE+ F+P +GG +V KVFD+KSGGV+MG
Sbjct: 121 VTTWKHPIVIGRHAFGDQYRATDLVVNGPGTFEIHFVPESGGAAQVQKVFDFKSGGVLMG 180
Query: 181 MYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKT 240
MYNTD+SI+DFA+SCFE+AL++KWPLYLSTKNTILK YDGRFKDIFAEMYKA YE +K
Sbjct: 181 MYNTDESIKDFAKSCFEYALSKKWPLYLSTKNTILKRYDGRFKDIFAEMYKASYEADYKK 240
Query: 241 CGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGK 300
GI+YEHRLIDDMVA+ M+SEGGYVWACKNYDGDVQSDS+AQGFGSLG+MTS+LM+PDG+
Sbjct: 241 AGIWYEHRLIDDMVAYAMKSEGGYVWACKNYDGDVQSDSVAQGFGSLGLMTSVLMSPDGR 300
Query: 301 TVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLED 360
TVE EAAHGTVTRHYR +QKG+ETSTNPVASIFAWTR L HR ++D N L++F+ LE
Sbjct: 301 TVEAEAAHGTVTRHYRQHQKGEETSTNPVASIFAWTRGLMHRGKLDQNEKLVQFSMLLEK 360
Query: 361 VIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
V+++TIEAG MT+DLAICIKG +V R+DYLNT EFI ++ ++ A ++SK+
Sbjct: 361 VVVSTIEAGFMTKDLAICIKGMNHVTRSDYLNTQEFIHKLADEMRKAYERSKI 413
>ref|XP_001650675.1| nadp-specific isocitrate dehydrogenase [Aedes aegypti]
gb|ABF18362.1| NADP-dependent isocitrate dehydrogenase [Aedes aegypti]
gb|EAT48221.1| nadp-specific isocitrate dehydrogenase [Aedes aegypti]
Length = 409
Score = 593 bits (1530), Expect = e-168, Method: Composition-based stats.
Identities = 280/406 (68%), Positives = 330/406 (81%), Gaps = 1/406 (0%)
Query: 3 KISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEAAY 62
KI A G +V++ GDEMTR+IW IKE LI PF+++ + YDL ME+RDKT+D+VT++ A
Sbjct: 4 KIKA-GPVVDILGDEMTRIIWDSIKEKLILPFLDIELHTYDLGMEHRDKTDDQVTIDCAE 62
Query: 63 AIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRLVT 122
A+KK+ VG+KCATITPDEARVKEFNLKKMWRSPNGTIR ILGGTVFRE IIC N+PRLV
Sbjct: 63 AVKKYNVGIKCATITPDEARVKEFNLKKMWRSPNGTIRNILGGTVFREAIICKNIPRLVP 122
Query: 123 TWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGGVMMGMY 182
W+KP+VIGRHA GDQY ATD VV G E++F P GGEP Y V YK GV M MY
Sbjct: 123 GWEKPIVIGRHAHGDQYKATDFVVPGAGDLEIKFTPKAGGEPISYVVHQYKGPGVAMAMY 182
Query: 183 NTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKTCG 242
N DDSI DFA S F+ AL RK+PLYLSTKNTILK YDGRFKDIF E+Y+ Y+T+F+ G
Sbjct: 183 NLDDSIVDFAHSSFKVALDRKFPLYLSTKNTILKKYDGRFKDIFQEIYEKEYKTQFEAAG 242
Query: 243 IFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGKTV 302
I+YEHRLIDDMVA+CM++EGG+VWACKNYDGDVQSD++AQGFGSLG+MTS+L+ PDGKTV
Sbjct: 243 IWYEHRLIDDMVAYCMKAEGGFVWACKNYDGDVQSDTVAQGFGSLGLMTSVLVCPDGKTV 302
Query: 303 EVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLEDVI 362
E EAAHGTVTRHYR YQ+GKETSTNP+ASIFAWTR L HRA++DNN L +F + LE V
Sbjct: 303 EAEAAHGTVTRHYRQYQQGKETSTNPIASIFAWTRGLLHRAKLDNNAELKKFAETLEKVC 362
Query: 363 IATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAM 408
I TIE+G+MT+DLAICIKG NV RADYL T EF+ + LK A+
Sbjct: 363 IDTIESGSMTKDLAICIKGMANVTRADYLETFEFMTKLGDNLKAAL 408
>gb|ACO14957.1| Isocitrate dehydrogenase cytoplasmic [Caligus clemensi]
Length = 409
Score = 590 bits (1522), Expect = e-167, Method: Composition-based stats.
Identities = 279/410 (68%), Positives = 330/410 (80%), Gaps = 1/410 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M+KI+A G +V++ GDEMTR+IW IKE LIFP + V + YDL +E RDKT+D+VTV+
Sbjct: 1 MSKINA-GPVVDILGDEMTRIIWDLIKEKLIFPHLEVELHTYDLGIEYRDKTDDKVTVDC 59
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIKK+ VG+KCATITPDE RV+EFNLKKMWRSPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 60 AEAIKKYNVGIKCATITPDENRVEEFNLKKMWRSPNGTIRNILGGTVFREAIICKNIPRL 119
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGGVMMG 180
VTTW KP+V+GRHA DQY A D V GT E+ F PANGGE YK+ D+K GV +G
Sbjct: 120 VTTWNKPIVVGRHAHADQYKAQDFKVPSEGTLELVFKPANGGEAMNYKIHDFKGPGVALG 179
Query: 181 MYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKT 240
MYNTD+SI+DFA CF+F+L R +PL+LSTKNTILK YDG FKDIF +Y Y++ F+
Sbjct: 180 MYNTDESIKDFAHCCFKFSLDRGYPLFLSTKNTILKKYDGAFKDIFQSIYDKEYKSDFEA 239
Query: 241 CGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGK 300
GI+YEHRLIDDMVA M+SEGG+VWACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDGK
Sbjct: 240 KGIYYEHRLIDDMVAQAMKSEGGFVWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGK 299
Query: 301 TVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLED 360
TVE EAAHGTVTRHYR +Q+GKETSTNP+ASIFAWTR LAHRA++DNN L F Q LED
Sbjct: 300 TVEAEAAHGTVTRHYRFHQRGKETSTNPIASIFAWTRGLAHRAKLDNNKGLANFCQALED 359
Query: 361 VIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQK 410
I TIE+G MT+DLAIC+KG NV R DYLNT EF+D +S+ LK + K
Sbjct: 360 TCIETIESGFMTKDLAICVKGMANVKREDYLNTFEFLDKLSENLKKKLGK 409
>ref|XP_001698704.1| isocitrate dehydrogenase, NADP-dependent [Chlamydomonas
reinhardtii]
gb|EDO99386.1| isocitrate dehydrogenase, NADP-dependent [Chlamydomonas
reinhardtii]
Length = 483
Score = 590 bits (1521), Expect = e-167, Method: Composition-based stats.
Identities = 268/399 (67%), Positives = 325/399 (81%)
Query: 3 KISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEAAY 62
KI +V+LDGDEMTRVIW++IK+ LI P++++ I Y+DL + NRDKT D+VT EAAY
Sbjct: 74 KIHVANPVVDLDGDEMTRVIWQQIKDKLILPYLDLKIVYFDLGLPNRDKTNDKVTEEAAY 133
Query: 63 AIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRLVT 122
AIK+H VG+KCATITPDEARVKEF LKKMW+SPNGTIR IL GTVFREPI+ SN+PRLV
Sbjct: 134 AIKEHNVGIKCATITPDEARVKEFGLKKMWKSPNGTIRNILNGTVFREPIVISNIPRLVP 193
Query: 123 TWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGGVMMGMY 182
W KP+V+GRHAFGDQY ATD VV PG EM F PA GG P+ ++V+ ++ GV MGMY
Sbjct: 194 GWTKPIVVGRHAFGDQYKATDFVVDGPGKLEMIFTPAAGGAPRKFEVYSFEGPGVAMGMY 253
Query: 183 NTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKTCG 242
NT++SIR FA SCFE+AL ++WPLYLSTKNTILK YDGRF IFAE Y+ Y+ +++ G
Sbjct: 254 NTEESIRGFASSCFEYALQKRWPLYLSTKNTILKSYDGRFLQIFAETYETQYKKQYEEAG 313
Query: 243 IFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGKTV 302
I+YEHRLIDDMVA ++S GG+VWACKNYDGDVQSD +AQG+GSLG+MTS+L+TPDGKTV
Sbjct: 314 IWYEHRLIDDMVAQGLKSSGGFVWACKNYDGDVQSDIVAQGYGSLGLMTSVLVTPDGKTV 373
Query: 303 EVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLEDVI 362
E EAAHGTVTRH+R+YQKGK TSTNPVASIFAWTR LAHR ++DNN L+++T LE +
Sbjct: 374 EAEAAHGTVTRHWREYQKGKPTSTNPVASIFAWTRGLAHRGKLDNNAELIQWTHDLEAAV 433
Query: 363 IATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVS 401
I TIE G MT+DLAIC+ G V YLNT+ F+DAV+
Sbjct: 434 IETIEQGHMTKDLAICVHGTTKVTPDQYLNTEPFMDAVA 472
>ref|XP_001841910.1| isocitrate dehydrogenase cytoplasmic [Culex pipiens
quinquefasciatus]
gb|EDS31763.1| isocitrate dehydrogenase cytoplasmic [Culex pipiens
quinquefasciatus]
Length = 409
Score = 589 bits (1519), Expect = e-166, Method: Composition-based stats.
Identities = 278/406 (68%), Positives = 331/406 (81%), Gaps = 1/406 (0%)
Query: 3 KISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEAAY 62
KI A G +V++ GDEMTR+IW IKE LI PF+++ + +DL +E+RDKTED+VTV+ A
Sbjct: 4 KIKA-GPVVDILGDEMTRIIWDSIKEKLILPFLDIELHTFDLGIEHRDKTEDQVTVDCAE 62
Query: 63 AIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRLVT 122
AIKK+ VG+KCATITPDEARV+EF LK+MWRSPNGTIR ILGGTVFRE IIC NVPRLV
Sbjct: 63 AIKKYNVGIKCATITPDEARVEEFKLKQMWRSPNGTIRNILGGTVFREAIICKNVPRLVP 122
Query: 123 TWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGGVMMGMY 182
W+KP+VIGRHA GDQY ATD VV GT E++F P++GGEP Y V YK GV M MY
Sbjct: 123 GWEKPIVIGRHAHGDQYKATDFVVPGAGTLELKFTPSSGGEPISYVVNQYKGPGVAMAMY 182
Query: 183 NTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKTCG 242
N DDSIRDFA S F+ AL RK+PLYLSTKNTILK YDGRFKDIF E+Y+A Y+ +++ G
Sbjct: 183 NLDDSIRDFAHSSFKVALDRKFPLYLSTKNTILKKYDGRFKDIFQEIYEADYKKQYEAAG 242
Query: 243 IFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGKTV 302
I+YEHRLIDDMVA+CM++EGG+VWACKNYDGDVQSD++AQGFGSLG+MTS+L+ PDGKTV
Sbjct: 243 IWYEHRLIDDMVAYCMKAEGGFVWACKNYDGDVQSDTVAQGFGSLGLMTSVLVCPDGKTV 302
Query: 303 EVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLEDVI 362
E EAAHGTVTRHYR YQ+GKETSTNP+ASIFAWTR L HRA++DNN L +F + LE V
Sbjct: 303 EAEAAHGTVTRHYRQYQQGKETSTNPIASIFAWTRGLLHRAKLDNNAELKKFAETLEKVC 362
Query: 363 IATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAM 408
I TIE+G MT+DLAICIKG V R+DYL T EF+ + LK A+
Sbjct: 363 IDTIESGFMTKDLAICIKGMSGVQRSDYLETFEFMTKLGDNLKAAL 408
>ref|XP_001688948.1| AGAP006660-PA [Anopheles gambiae str. PEST]
ref|XP_001688949.1| AGAP006660-PB [Anopheles gambiae str. PEST]
ref|XP_316694.4| AGAP006660-PC [Anopheles gambiae str. PEST]
gb|EDO63954.1| AGAP006660-PA [Anopheles gambiae str. PEST]
gb|EDO63955.1| AGAP006660-PB [Anopheles gambiae str. PEST]
gb|EAA11493.4| AGAP006660-PC [Anopheles gambiae str. PEST]
Length = 413
Score = 586 bits (1510), Expect = e-165, Method: Composition-based stats.
Identities = 272/412 (66%), Positives = 334/412 (81%), Gaps = 1/412 (0%)
Query: 2 NKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEAA 61
+KI A G +V++ GDEMTR+IW IKE LI PF+++ + YDL +E+RD T D+VT++ A
Sbjct: 3 SKIKA-GPVVDILGDEMTRIIWDSIKEKLILPFLDIELHTYDLGIEHRDATNDQVTIDCA 61
Query: 62 YAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRLV 121
A+K++ VG+KCATITPDEARV+EF LK+MWRSPNGTIR ILGGTVFRE IIC NVPRLV
Sbjct: 62 EAVKRYNVGIKCATITPDEARVEEFKLKQMWRSPNGTIRNILGGTVFREAIICKNVPRLV 121
Query: 122 TTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGGVMMGM 181
W+KP++IGRHA GDQY ATD VV PG EM+F PA+G EP Y V +YKS GV MGM
Sbjct: 122 PGWEKPIIIGRHAHGDQYKATDFVVPVPGKLEMKFTPADGSEPTTYVVNEYKSAGVAMGM 181
Query: 182 YNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKTC 241
YN DDSI DFA S F+ AL RK+PLYLSTKNTILK YDGRFKDIF E+Y Y+ +F+
Sbjct: 182 YNLDDSICDFAHSSFKVALDRKFPLYLSTKNTILKKYDGRFKDIFQEIYDKDYKKQFEAL 241
Query: 242 GIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGKT 301
GI+YEHRLIDDMVA+CM++EGG+VWACKNYDGDVQSD++AQGFGSLG+MTS+L+ PDG+T
Sbjct: 242 GIWYEHRLIDDMVAYCMKAEGGFVWACKNYDGDVQSDTVAQGFGSLGLMTSVLVCPDGRT 301
Query: 302 VEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLEDV 361
VE EAAHGTVTRHYR +Q+GKETSTNP+ASIFAWTR L HRA++D+N L F + LE V
Sbjct: 302 VESEAAHGTVTRHYRQHQQGKETSTNPIASIFAWTRGLLHRAKLDDNAELKRFAETLEKV 361
Query: 362 IIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
I TIE+G MT+DLAICIKG NV R DY+ T EF++ + + L+ A+ +S++
Sbjct: 362 CIDTIESGFMTKDLAICIKGMANVKRTDYMETFEFMNKLGENLQAALTQSRL 413
>ref|XP_421965.2| PREDICTED: similar to cytosolic NADP-dependent isocitrate
dehydrogenase [Gallus gallus]
Length = 415
Score = 585 bits (1509), Expect = e-165, Method: Composition-based stats.
Identities = 274/406 (67%), Positives = 331/406 (81%), Gaps = 1/406 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M+K G +VE+ GDEMTRVIW+ IKE LIFP+V++ + YDL +E+RD T D+VTVEA
Sbjct: 1 MSKKIHGGSVVEMQGDEMTRVIWELIKEKLIFPYVDLDLHSYDLGIEHRDATNDKVTVEA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIKK+ VG+KCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 61 AEAIKKYHVGIKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKS-GGVMM 179
V+ W KP+VIGRHA+GDQY ATD VV PG EM + P +GG+P Y V +++S GGV M
Sbjct: 121 VSGWVKPIVIGRHAYGDQYRATDFVVPGPGKVEMTYTPGDGGKPVTYLVHNFESCGGVAM 180
Query: 180 GMYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFK 239
GMYN D SI+DFA S F+ AL++ WPLY+STKNTILK YDGRFKDIF E+Y Y+++F+
Sbjct: 181 GMYNLDQSIKDFAHSSFQMALSKGWPLYMSTKNTILKRYDGRFKDIFQEIYDREYKSQFE 240
Query: 240 TCGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDG 299
I+YEHRLIDDMVA ++SEGG+VWACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDG
Sbjct: 241 AKKIWYEHRLIDDMVAQALKSEGGFVWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDG 300
Query: 300 KTVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLE 359
KTVE EAAHGTVTRHYR +QKG+ETSTNP+ASIFAWTR LAHRA++DNN +L F LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMHQKGQETSTNPIASIFAWTRGLAHRAKLDNNTSLKTFATALE 360
Query: 360 DVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLK 405
+V I TIE+G MT+DLA CIKG NV R+DYLNT EF+D ++ LK
Sbjct: 361 EVCIETIESGFMTKDLAACIKGLPNVTRSDYLNTFEFMDKLAANLK 406
>gb|ABU41004.1| isocitrate dehydrogenase 1 [Anser anser]
Length = 415
Score = 585 bits (1508), Expect = e-165, Method: Composition-based stats.
Identities = 273/406 (67%), Positives = 332/406 (81%), Gaps = 1/406 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M+K G +VE+ GDEMTRVIW+ IKE LIFP+V++ + YDL +E+RD T D+VTVEA
Sbjct: 1 MSKKIHGGSVVEMQGDEMTRVIWELIKEKLIFPYVDLDLHSYDLGIEHRDATNDKVTVEA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIKK+ VG+KCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 61 AEAIKKYHVGIKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKS-GGVMM 179
V+ W KP+VIGRHA+GDQY ATD VV PG EM + P +GG+P Y V +++S GGV M
Sbjct: 121 VSGWVKPIVIGRHAYGDQYRATDFVVPGPGKVEMTYTPGDGGKPVTYLVHNFESCGGVAM 180
Query: 180 GMYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFK 239
GM+N D SI+DFA S F+ AL++ WPLY+STKNTILK YDGRFKDIF E+Y Y+++F+
Sbjct: 181 GMFNLDQSIKDFAHSSFQMALSKGWPLYMSTKNTILKRYDGRFKDIFQEIYDREYKSQFE 240
Query: 240 TCGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDG 299
I+YEHRLIDDMVA ++SEGG+VWACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDG
Sbjct: 241 AKKIWYEHRLIDDMVAQALKSEGGFVWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDG 300
Query: 300 KTVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLE 359
KTVE EAAHGTVTRHYR +QKG+ETSTNP+ASIFAWTR LAHRA++DNN +L F LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMHQKGQETSTNPIASIFAWTRGLAHRAKLDNNTSLKTFAAALE 360
Query: 360 DVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLK 405
+V I TIE+G MT+DLA CIKG NV R+DYLNT EF+D +++ LK
Sbjct: 361 EVCIETIESGFMTKDLAACIKGLPNVTRSDYLNTFEFMDKLAENLK 406
>emb|CAG38738.1| IDH1 [Homo sapiens]
Length = 414
Score = 584 bits (1506), Expect = e-165, Method: Composition-based stats.
Identities = 274/414 (66%), Positives = 332/414 (80%), Gaps = 1/414 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M+K + G +VE+ GDEMTR+IW+ IKE LIFP+V + + YDL +ENRD T D+VT +A
Sbjct: 1 MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIKKH VGVKCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 61 AEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGG-VMM 179
V+ W KP++IGRHA+GDQY ATD VV PG EM + P++G + Y V +++ GG V M
Sbjct: 121 VSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEMTYTPSDGTQKVTYLVHNFEEGGGVAM 180
Query: 180 GMYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFK 239
GMYN D SI DFA S F+ AL++ WPLYLSTKNTILK YDGRFKDIF E+Y Y+++F+
Sbjct: 181 GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE 240
Query: 240 TCGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDG 299
I+YEHRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDG
Sbjct: 241 AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG 300
Query: 300 KTVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLE 359
KTVE EAAHGTVTRHYR YQKG+ETSTNP+ASIFAWTR LAHRA++DNN L F LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALE 360
Query: 360 DVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
+V I TIEAG MT+DLA CIKG NV R+DYLNT EF+D + + LK+ + ++K+
Sbjct: 361 EVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL 414
>ref|NP_001009276.1| cytosolic NADP-isocitrate dehydrogenase [Ovis aries]
sp|Q6XUZ5|IDHC_SHEEP Isocitrate dehydrogenase [NADP] cytoplasmic (Cytosolic
NADP-isocitrate dehydrogenase) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP)
gb|AAP41947.1| cytosolic NADP-isocitrate dehydrogenase [Ovis aries]
Length = 414
Score = 583 bits (1503), Expect = e-165, Method: Composition-based stats.
Identities = 271/407 (66%), Positives = 332/407 (81%), Gaps = 1/407 (0%)
Query: 8 GVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEAAYAIKKH 67
G +VE+ GDEMTR+IW+ IKE LIFP+V++ + YDLS+ENRD T D+VT +AA AIKK+
Sbjct: 8 GSVVEMQGDEMTRIIWELIKEKLIFPYVDLDLHSYDLSIENRDATNDQVTKDAAEAIKKY 67
Query: 68 GVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRLVTTWKKP 127
VGVKCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRLV+ W KP
Sbjct: 68 NVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKP 127
Query: 128 VVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDY-KSGGVMMGMYNTDD 186
++IGRHA+GDQY ATD VV PG E+ + P++G VY V ++ +SGGV MGM+N D
Sbjct: 128 IIIGRHAYGDQYRATDFVVPGPGKVEICYTPSDGSPKTVYLVHNFTESGGVAMGMFNQDK 187
Query: 187 SIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKTCGIFYE 246
SI DFA S F+ AL++ WPLYLSTKNTILK YDGRFKDIF E+Y Y+++F+ I+YE
Sbjct: 188 SIEDFAHSSFQMALSKNWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQNIWYE 247
Query: 247 HRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGKTVEVEA 306
HRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDGKTVE EA
Sbjct: 248 HRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEA 307
Query: 307 AHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLEDVIIATI 366
AHGTVTRHYR YQKG+ETSTNP+ASIFAWTR LAHRA++DNN L F + LE+V I TI
Sbjct: 308 AHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELSFFAKALEEVCIETI 367
Query: 367 EAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
EAG MT+DLA CIKG NV R+DYLNT EF+D + + L++ + ++K+
Sbjct: 368 EAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLQLKLAQAKL 414
>ref|XP_860821.1| PREDICTED: similar to Isocitrate dehydrogenase [NADP] cytoplasmic
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) (IDP) isoform 4 [Canis familiaris]
Length = 415
Score = 583 bits (1503), Expect = e-165, Method: Composition-based stats.
Identities = 270/408 (66%), Positives = 328/408 (80%), Gaps = 2/408 (0%)
Query: 8 GVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEAAYAIKKH 67
G +VE+ GDEMTR+IW+ IKE LIFP+V + + YDL +ENRD T D+VT +AA AIKK+
Sbjct: 8 GSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKY 67
Query: 68 GVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRLVTTWKKP 127
VGVKCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRLV+ W KP
Sbjct: 68 NVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKP 127
Query: 128 VVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVY--KVFDYKSGGVMMGMYNTD 185
++IGRHA+GDQY ATD VV PG E+ + P++G E Y +V +K GGV MGMYN D
Sbjct: 128 IIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGSEKMTYLIQVLSFKGGGVAMGMYNQD 187
Query: 186 DSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKTCGIFY 245
SI DFA S F+ AL++ WPLYLSTKNTILK YDGRFKDIF E+Y Y+++F+ I+Y
Sbjct: 188 KSIEDFAHSSFQMALSKSWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQNIWY 247
Query: 246 EHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGKTVEVE 305
EHRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDGKTVE E
Sbjct: 248 EHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAE 307
Query: 306 AAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLEDVIIAT 365
AAHGTVTRHYR YQKG+ETSTNP+ASIFAWTR LAHRA++DNN L F + LE+V + T
Sbjct: 308 AAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELSFFAKALEEVCVET 367
Query: 366 IEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
IEAG MT+DLA CIKG NV R+DYLNT EF+D + + L + + ++K+
Sbjct: 368 IEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLNIKLAQAKL 415
>ref|XP_001511049.1| PREDICTED: similar to cytosolic NADP-dependent isocitrate
dehydrogenase [Ornithorhynchus anatinus]
Length = 415
Score = 583 bits (1503), Expect = e-165, Method: Composition-based stats.
Identities = 270/402 (67%), Positives = 326/402 (81%), Gaps = 1/402 (0%)
Query: 8 GVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEAAYAIKKH 67
G +VE+ GDEMTRVIW+ IKE LIFP+V++ + YDL +ENRD T D+VT EAA AIKK+
Sbjct: 8 GSVVEMQGDEMTRVIWELIKEKLIFPYVDLDLHSYDLGIENRDATNDKVTSEAAEAIKKY 67
Query: 68 GVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRLVTTWKKP 127
VG+KCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRLV+ W KP
Sbjct: 68 NVGIKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKP 127
Query: 128 VVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGG-VMMGMYNTDD 186
++IGRHA+GDQY ATD VV PG EM + P +GG+ Y V ++++GG V MGMYN D
Sbjct: 128 IIIGRHAYGDQYRATDFVVPRPGKVEMVYTPQDGGKAVTYLVHNFEAGGGVAMGMYNLDQ 187
Query: 187 SIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKTCGIFYE 246
SIRDFA S F+ AL++ WPLY+STKNTILK YDGRFKDIF E+Y+ Y +KF+ I+YE
Sbjct: 188 SIRDFAHSSFQMALSKSWPLYMSTKNTILKRYDGRFKDIFQEIYEKQYRSKFEAKKIWYE 247
Query: 247 HRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGKTVEVEA 306
HRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDGKTVE EA
Sbjct: 248 HRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDGKTVEAEA 307
Query: 307 AHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLEDVIIATI 366
AHGTVTRH+R +QKG+ETSTNP+ASIFAW+R LAHRA++DNN L F LEDV + TI
Sbjct: 308 AHGTVTRHFRMHQKGQETSTNPIASIFAWSRGLAHRAKLDNNTELSTFATTLEDVCVETI 367
Query: 367 EAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAM 408
EAG MT+DLA CIKG NV R+DYLNT EF+D + + LK +
Sbjct: 368 EAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKAKL 409
>ref|XP_001107627.1| PREDICTED: isocitrate dehydrogenase 1 (NADP+), soluble isoform 1
[Macaca mulatta]
ref|XP_001107810.1| PREDICTED: isocitrate dehydrogenase 1 (NADP+), soluble isoform 2
[Macaca mulatta]
ref|XP_001107875.1| PREDICTED: isocitrate dehydrogenase 1 (NADP+), soluble isoform 3
[Macaca mulatta]
ref|XP_001107934.1| PREDICTED: isocitrate dehydrogenase 1 (NADP+), soluble isoform 4
[Macaca mulatta]
ref|XP_001107992.1| PREDICTED: isocitrate dehydrogenase 1 (NADP+), soluble isoform 5
[Macaca mulatta]
Length = 414
Score = 583 bits (1502), Expect = e-164, Method: Composition-based stats.
Identities = 273/414 (65%), Positives = 333/414 (80%), Gaps = 1/414 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M+K + G +VEL GDEMTR+IW+ IKE LIFP+V + ++ YDL +ENRD T D+VT +A
Sbjct: 1 MSKKISGGSVVELQGDEMTRIIWELIKEKLIFPYVELDLQSYDLGIENRDATNDQVTKDA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIKK+ VGVKCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 61 AEAIKKYNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGG-VMM 179
V+ W KP++IGRHA+GDQY ATD VV PG E+ + P++G + Y V +++ GG V M
Sbjct: 121 VSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAM 180
Query: 180 GMYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFK 239
GMYN D SI DFA S F+ AL++ WPLYLSTKNTILK YDGRFKDIF E+Y Y+++F+
Sbjct: 181 GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE 240
Query: 240 TCGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDG 299
I+YEHRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDG
Sbjct: 241 AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG 300
Query: 300 KTVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLE 359
KTVE EAAHGTVTRHYR YQKG+ETSTNP+ASIFAWTR LAHRA++DNN L F LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALE 360
Query: 360 DVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
+V I TIEAG MT+DLA CIKG NV R+DYLNT EF+D + + LK+ + ++K+
Sbjct: 361 EVCIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL 414
>ref|NP_005887.2| isocitrate dehydrogenase 1 (NADP+), soluble [Homo sapiens]
sp|O75874|IDHC_HUMAN Isocitrate dehydrogenase [NADP] cytoplasmic (Cytosolic
NADP-isocitrate dehydrogenase) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP)
pdb|1T09|A Chain A, Crystal Structure Of Human Cytosolic Nadp(+)-Dependent
Isocitrate Dehydrogenase In Complex Nadp
pdb|1T09|B Chain B, Crystal Structure Of Human Cytosolic Nadp(+)-Dependent
Isocitrate Dehydrogenase In Complex Nadp
pdb|1T0L|A Chain A, Crystal Structure Of Human Cytosolic Nadp(+)-Dependent
Isocitrate Dehydrogenase In Complex With Nadp,
Isocitrate, And Calcium(2+)
pdb|1T0L|B Chain B, Crystal Structure Of Human Cytosolic Nadp(+)-Dependent
Isocitrate Dehydrogenase In Complex With Nadp,
Isocitrate, And Calcium(2+)
pdb|1T0L|C Chain C, Crystal Structure Of Human Cytosolic Nadp(+)-Dependent
Isocitrate Dehydrogenase In Complex With Nadp,
Isocitrate, And Calcium(2+)
pdb|1T0L|D Chain D, Crystal Structure Of Human Cytosolic Nadp(+)-Dependent
Isocitrate Dehydrogenase In Complex With Nadp,
Isocitrate, And Calcium(2+)
gb|AAD29284.1|AF113917_1 NADP+-dependent isocitrate dehydrogenase [Homo sapiens]
gb|AAH12846.1| IDH1 protein [Homo sapiens]
emb|CAG46496.1| IDH1 [Homo sapiens]
gb|AAX93221.1| unknown [Homo sapiens]
gb|EAW70439.1| isocitrate dehydrogenase 1 (NADP+), soluble, isoform CRA_a [Homo
sapiens]
gb|EAW70441.1| isocitrate dehydrogenase 1 (NADP+), soluble, isoform CRA_a [Homo
sapiens]
gb|EAW70442.1| isocitrate dehydrogenase 1 (NADP+), soluble, isoform CRA_a [Homo
sapiens]
gb|ABM82361.1| isocitrate dehydrogenase 1 (NADP+), soluble [synthetic construct]
gb|ABW03396.1| isocitrate dehydrogenase 1 (NADP+), soluble [synthetic construct]
Length = 414
Score = 582 bits (1501), Expect = e-164, Method: Composition-based stats.
Identities = 273/414 (65%), Positives = 332/414 (80%), Gaps = 1/414 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M+K + G +VE+ GDEMTR+IW+ IKE LIFP+V + + YDL +ENRD T D+VT +A
Sbjct: 1 MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIKKH VGVKCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 61 AEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGG-VMM 179
V+ W KP++IGRHA+GDQY ATD VV PG E+ + P++G + Y V +++ GG V M
Sbjct: 121 VSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAM 180
Query: 180 GMYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFK 239
GMYN D SI DFA S F+ AL++ WPLYLSTKNTILK YDGRFKDIF E+Y Y+++F+
Sbjct: 181 GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE 240
Query: 240 TCGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDG 299
I+YEHRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDG
Sbjct: 241 AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG 300
Query: 300 KTVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLE 359
KTVE EAAHGTVTRHYR YQKG+ETSTNP+ASIFAWTR LAHRA++DNN L F LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALE 360
Query: 360 DVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
+V I TIEAG MT+DLA CIKG NV R+DYLNT EF+D + + LK+ + ++K+
Sbjct: 361 EVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL 414
>ref|NP_851355.2| isocitrate dehydrogenase 1 (NADP+), soluble [Bos taurus]
gb|AAI03369.1| Isocitrate dehydrogenase 1 (NADP+), soluble [Bos taurus]
Length = 414
Score = 582 bits (1501), Expect = e-164, Method: Composition-based stats.
Identities = 271/407 (66%), Positives = 330/407 (81%), Gaps = 1/407 (0%)
Query: 8 GVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEAAYAIKKH 67
G +VE+ GDEMTR+IW+ IKE LIFP+V + + YDL +ENRD T D+VT +AA AIKK+
Sbjct: 8 GSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKY 67
Query: 68 GVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRLVTTWKKP 127
VGVKCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRLV+ W KP
Sbjct: 68 NVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKP 127
Query: 128 VVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDY-KSGGVMMGMYNTDD 186
++IGRHA+GDQY ATD VV PG E+ + P++G VY V ++ +SGGV MGMYN D
Sbjct: 128 IIIGRHAYGDQYRATDFVVPGPGKVEISYTPSDGSPKTVYLVHNFTESGGVAMGMYNQDK 187
Query: 187 SIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKTCGIFYE 246
SI DFA S F+ AL++ WPLYLSTKNTILK YDGRFKDIF E+Y Y+++F+ I+YE
Sbjct: 188 SIEDFAHSSFQMALSKNWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSEFEAQNIWYE 247
Query: 247 HRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGKTVEVEA 306
HRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDGKTVE EA
Sbjct: 248 HRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEA 307
Query: 307 AHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLEDVIIATI 366
AHGTVTRHYR YQKG+ETSTNP+ASIFAWTR LAHRA++DNN L F + LE+V I TI
Sbjct: 308 AHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELSFFAKALEEVCIETI 367
Query: 367 EAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
EAG MT+DLA CIKG NV R+DYLNT EF+D + + L++ + ++K+
Sbjct: 368 EAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLQLKLAQAKL 414
>gb|AAH93020.1| Isocitrate dehydrogenase 1 (NADP+), soluble [Homo sapiens]
Length = 414
Score = 582 bits (1499), Expect = e-164, Method: Composition-based stats.
Identities = 272/414 (65%), Positives = 332/414 (80%), Gaps = 1/414 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M+K + G +VE+ GDEMTR+IW+ IKE LIFP+V + + YDL +ENRD T D+VT +A
Sbjct: 1 MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIKKH VGVKCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 61 AEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGG-VMM 179
V+ W KP++IGRHA+GDQY ATD VV PG E+ + P++G + Y V +++ GG V M
Sbjct: 121 VSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAM 180
Query: 180 GMYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFK 239
GMYN D SI DFA S F+ AL++ WPLYLSTKNTILK YDGRFKDIF E+Y Y+++F+
Sbjct: 181 GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE 240
Query: 240 TCGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDG 299
I+YEHRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDG
Sbjct: 241 AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG 300
Query: 300 KTVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLE 359
KTVE E+AHGTVTRHYR YQKG+ETSTNP+ASIFAWTR LAHRA++DNN L F LE
Sbjct: 301 KTVEAESAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALE 360
Query: 360 DVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
+V I TIEAG MT+DLA CIKG NV R+DYLNT EF+D + + LK+ + ++K+
Sbjct: 361 EVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL 414
>emb|CAD97653.1| hypothetical protein [Homo sapiens]
emb|CAL38069.1| hypothetical protein [synthetic construct]
emb|CAL37462.1| hypothetical protein [synthetic construct]
Length = 414
Score = 581 bits (1497), Expect = e-164, Method: Composition-based stats.
Identities = 273/414 (65%), Positives = 331/414 (79%), Gaps = 1/414 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M+K + G +VE+ GDEMTR+IW+ IKE LIFP+V + + YDL +ENRD T D+VT +A
Sbjct: 1 MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIKKH VGVKCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 61 AEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGG-VMM 179
V+ W KP++IGRHA+GDQY ATD VV PG E+ + P++G + Y V + + GG V M
Sbjct: 121 VSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNSEGGGGVAM 180
Query: 180 GMYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFK 239
GMYN D SI DFA S F+ AL++ WPLYLSTKNTILK YDGRFKDIF E+Y Y+++F+
Sbjct: 181 GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE 240
Query: 240 TCGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDG 299
I+YEHRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDG
Sbjct: 241 AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG 300
Query: 300 KTVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLE 359
KTVE EAAHGTVTRHYR YQKG+ETSTNP+ASIFAWTR LAHRA++DNN L F LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALE 360
Query: 360 DVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
+V I TIEAG MT+DLA CIKG NV R+DYLNT EF+D + + LK+ + ++K+
Sbjct: 361 EVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL 414
>ref|XP_001505172.1| PREDICTED: similar to Isocitrate dehydrogenase [NADP] cytoplasmic
(Cytosolic NADP-isocitrate dehydrogenase)
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) (IDP) [Equus caballus]
Length = 414
Score = 581 bits (1497), Expect = e-164, Method: Composition-based stats.
Identities = 270/407 (66%), Positives = 328/407 (80%), Gaps = 1/407 (0%)
Query: 8 GVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEAAYAIKKH 67
G +VE+ GDEMTR+IW+ IKE LIFP V + + YDL +ENRD T D+VT +AA AIKK+
Sbjct: 8 GSVVEMQGDEMTRIIWELIKEKLIFPHVELDLHSYDLGIENRDATNDQVTKDAAEAIKKY 67
Query: 68 GVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRLVTTWKKP 127
VGVKCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRLV+ W KP
Sbjct: 68 NVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKP 127
Query: 128 VVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGG-VMMGMYNTDD 186
++IGRHA+GDQY ATD VV PG E+ + P++G + + Y V +++ GG V MGMYN D
Sbjct: 128 IIIGRHAYGDQYRATDFVVPGPGRVEITYTPSDGSQKRTYLVHNFEEGGGVAMGMYNQDK 187
Query: 187 SIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKTCGIFYE 246
SI DFA S F+ AL++ WPLYLSTKNTILK YDGRFKDIF E+Y Y ++F+ I+YE
Sbjct: 188 SIEDFAHSSFQMALSKSWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYRSQFEAQKIWYE 247
Query: 247 HRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGKTVEVEA 306
HRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDGKTVE EA
Sbjct: 248 HRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEA 307
Query: 307 AHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLEDVIIATI 366
AHGTVTRHYR YQKG+ETSTNP+ASIFAWTR LAHRA++DNN L F + LEDV + TI
Sbjct: 308 AHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELGFFAKALEDVCVETI 367
Query: 367 EAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
EAG MT+DLA CIKG NV R+DYLNT EF+D + + LK+ + ++K+
Sbjct: 368 EAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL 414
>ref|NP_001088022.1| hypothetical protein LOC494713 [Xenopus laevis]
gb|AAH82651.1| LOC494713 protein [Xenopus laevis]
Length = 415
Score = 581 bits (1497), Expect = e-164, Method: Composition-based stats.
Identities = 270/409 (66%), Positives = 329/409 (80%), Gaps = 1/409 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M+K G +VE+ GDEMTRVIW IKE LI P+V + + YDL MENRD T+D+VTV+A
Sbjct: 1 MSKKINGGSVVEMQGDEMTRVIWDLIKEKLILPYVELDLHSYDLGMENRDATDDQVTVDA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIKK+ VG+KCATITPDE RV+EFNLK+MW+SPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 61 AEAIKKYNVGIKCATITPDEKRVEEFNLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKS-GGVMM 179
V+ W KP++IGRHA+GDQY ATD VV PG E+ F P +GGE Y + +++ GGV +
Sbjct: 121 VSGWIKPIIIGRHAYGDQYRATDFVVPGPGKVEISFTPKDGGEAIKYVIHNFEDCGGVAL 180
Query: 180 GMYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFK 239
GMYNTD SIRDFA S F+ AL++ WPLY+STKNTILK YDGRFKDIF E+Y+ Y+++F+
Sbjct: 181 GMYNTDQSIRDFAHSSFQMALSKSWPLYMSTKNTILKRYDGRFKDIFQEIYEKEYKSQFE 240
Query: 240 TCGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDG 299
I+YEHRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDG
Sbjct: 241 ENKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDG 300
Query: 300 KTVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLE 359
KTVE EAAHGTVTRHYR +QKG+ETSTNP+ASIFAW+R L HRA++DNN L F LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMHQKGQETSTNPIASIFAWSRGLDHRAKLDNNQELKNFATALE 360
Query: 360 DVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAM 408
+V I TIEAG MT+DLA CIKG NV R DYL+T EF+D + + L++ +
Sbjct: 361 EVCIETIEAGFMTKDLAACIKGLPNVQRGDYLSTFEFMDKLGENLQLKL 409
>sp|Q9XSG3|IDHC_BOVIN Isocitrate dehydrogenase [NADP] cytoplasmic (Cytosolic
NADP-isocitrate dehydrogenase) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP)
gb|AAD34457.1|AF136009_1 cytosolic NADP+-dependent isocitrate dehydrogenase [Bos taurus]
Length = 414
Score = 580 bits (1495), Expect = e-164, Method: Composition-based stats.
Identities = 270/407 (66%), Positives = 329/407 (80%), Gaps = 1/407 (0%)
Query: 8 GVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEAAYAIKKH 67
G +VE+ GDEMTR+IW+ IKE LIFP+V + + YDL +ENRD T D+VT +AA AIKK+
Sbjct: 8 GSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKY 67
Query: 68 GVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRLVTTWKKP 127
VGVKCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRLV+ W KP
Sbjct: 68 NVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKP 127
Query: 128 VVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDY-KSGGVMMGMYNTDD 186
++IGRHA+GDQY ATD VV PG E+ + P++G VY V ++ +SGGV MGMYN D
Sbjct: 128 IIIGRHAYGDQYRATDFVVPGPGKVEISYTPSDGSPKTVYLVHNFTESGGVAMGMYNQDK 187
Query: 187 SIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKTCGIFYE 246
SI DFA S F+ AL++ WPLYLSTKNTILK YDGRFKDIF E+Y Y+++F+ I+YE
Sbjct: 188 SIEDFAHSSFQMALSKNWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSEFEAQNIWYE 247
Query: 247 HRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGKTVEVEA 306
HRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDGKTVE EA
Sbjct: 248 HRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEA 307
Query: 307 AHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLEDVIIATI 366
AHGTVTRHYR YQKG+ET TNP+ASIFAWTR LAHRA++DNN L F + LE+V I TI
Sbjct: 308 AHGTVTRHYRMYQKGQETLTNPIASIFAWTRGLAHRAKLDNNKELSFFAKALEEVCIETI 367
Query: 367 EAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
EAG MT+DLA CIKG NV R+DYLNT EF+D + + L++ + ++K+
Sbjct: 368 EAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLQLKLAQAKL 414
>ref|XP_850187.1| PREDICTED: similar to Isocitrate dehydrogenase [NADP] cytoplasmic
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) (IDP) isoform 2 [Canis familiaris]
ref|XP_536047.2| PREDICTED: similar to Isocitrate dehydrogenase [NADP] cytoplasmic
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) (IDP) isoform 1 [Canis familiaris]
Length = 414
Score = 580 bits (1495), Expect = e-164, Method: Composition-based stats.
Identities = 269/407 (66%), Positives = 328/407 (80%), Gaps = 1/407 (0%)
Query: 8 GVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEAAYAIKKH 67
G +VE+ GDEMTR+IW+ IKE LIFP+V + + YDL +ENRD T D+VT +AA AIKK+
Sbjct: 8 GSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKY 67
Query: 68 GVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRLVTTWKKP 127
VGVKCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRLV+ W KP
Sbjct: 68 NVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKP 127
Query: 128 VVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGG-VMMGMYNTDD 186
++IGRHA+GDQY ATD VV PG E+ + P++G E Y V +++ GG V MGMYN D
Sbjct: 128 IIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGSEKMTYLVHNFEEGGGVAMGMYNQDK 187
Query: 187 SIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKTCGIFYE 246
SI DFA S F+ AL++ WPLYLSTKNTILK YDGRFKDIF E+Y Y+++F+ I+YE
Sbjct: 188 SIEDFAHSSFQMALSKSWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQNIWYE 247
Query: 247 HRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGKTVEVEA 306
HRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDGKTVE EA
Sbjct: 248 HRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEA 307
Query: 307 AHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLEDVIIATI 366
AHGTVTRHYR YQKG+ETSTNP+ASIFAWTR LAHRA++DNN L F + LE+V + TI
Sbjct: 308 AHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELSFFAKALEEVCVETI 367
Query: 367 EAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
EAG MT+DLA CIKG NV R+DYLNT EF+D + + L + + ++K+
Sbjct: 368 EAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLNIKLAQAKL 414
>ref|NP_958907.1| isocitrate dehydrogenase 1 (NADP+), soluble [Danio rerio]
gb|AAH46894.1| Isocitrate dehydrogenase 1 (NADP+), soluble [Danio rerio]
gb|AAI65569.1| Idh1 protein [synthetic construct]
Length = 429
Score = 580 bits (1494), Expect = e-163, Method: Composition-based stats.
Identities = 270/409 (66%), Positives = 327/409 (79%), Gaps = 1/409 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M++ G +VE+ GDEMTRVIW+ IKE LIFP++ + + YDL MENRD T+D+VTVEA
Sbjct: 15 MSQKVKAGSVVEMQGDEMTRVIWELIKEKLIFPYLELDLHSYDLGMENRDATDDKVTVEA 74
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A A++++ VG+KCATITPDE RV+EF LK+MWRSPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 75 AEAVRRYNVGIKCATITPDEKRVEEFKLKQMWRSPNGTIRNILGGTVFREAIICKNIPRL 134
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYK-SGGVMM 179
V W KP++IGRHA GDQY ATD VV PGT EM + P NGGE + V D++ +GGV +
Sbjct: 135 VPGWIKPIIIGRHAHGDQYKATDFVVPGPGTVEMTYKPKNGGETLKFVVHDFEGTGGVAL 194
Query: 180 GMYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFK 239
GMYNTD SIRDFA S F+ L + WP+YLSTKNTILK YDGRFKDIF E+Y Y+ K++
Sbjct: 195 GMYNTDKSIRDFAHSSFQMGLNKGWPMYLSTKNTILKKYDGRFKDIFQEIYDKEYKAKYE 254
Query: 240 TCGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDG 299
GI+YEHRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDG
Sbjct: 255 AMGIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG 314
Query: 300 KTVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLE 359
+TVE EAAHGTVTRHYR +Q+GKETSTNP+ASIFAWTR L HRA +D N L F + LE
Sbjct: 315 RTVEAEAAHGTVTRHYRMHQQGKETSTNPIASIFAWTRGLLHRAELDKNAELRVFAEALE 374
Query: 360 DVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAM 408
V + TIEAG MT+DLAICIKG V R+DYLNT EF+D +++ LK+ +
Sbjct: 375 VVCVETIEAGFMTKDLAICIKGMSGVTRSDYLNTFEFLDKLAENLKIKL 423
>ref|XP_001141655.1| PREDICTED: isocitrate dehydrogenase 1 (NADP+), soluble isoform 1
[Pan troglodytes]
ref|XP_001141734.1| PREDICTED: isocitrate dehydrogenase 1 (NADP+), soluble isoform 2
[Pan troglodytes]
ref|XP_001141810.1| PREDICTED: isocitrate dehydrogenase 1 (NADP+), soluble isoform 3
[Pan troglodytes]
ref|XP_001141879.1| PREDICTED: isocitrate dehydrogenase 1 (NADP+), soluble isoform 4
[Pan troglodytes]
ref|XP_001141947.1| PREDICTED: isocitrate dehydrogenase 1 (NADP+), soluble isoform 5
[Pan troglodytes]
ref|XP_001142041.1| PREDICTED: isocitrate dehydrogenase 1 (NADP+), soluble isoform 6
[Pan troglodytes]
ref|XP_001142113.1| PREDICTED: isocitrate dehydrogenase 1 (NADP+), soluble isoform 7
[Pan troglodytes]
ref|XP_001142197.1| PREDICTED: isocitrate dehydrogenase 1 (NADP+), soluble isoform 8
[Pan troglodytes]
Length = 414
Score = 579 bits (1493), Expect = e-163, Method: Composition-based stats.
Identities = 272/414 (65%), Positives = 332/414 (80%), Gaps = 1/414 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M+K + G +VE+ GDEMTR+IW+ IKE LIFP+V + + YDL +ENRD T D+VT +A
Sbjct: 1 MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIKK+ VGVKCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 61 AEAIKKYNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGG-VMM 179
V+ W KP++IGRHA+GDQY ATD VV PG E+ + P++G + Y V +++ GG V M
Sbjct: 121 VSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAM 180
Query: 180 GMYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFK 239
GMYN D SI DFA S F+ AL++ WPLYLSTKNTILK YDGRFKDIF E+Y Y+++F+
Sbjct: 181 GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKRYKSQFE 240
Query: 240 TCGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDG 299
I+YEHRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDG
Sbjct: 241 AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG 300
Query: 300 KTVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLE 359
KTVE EAAHGTVTRHYR YQKG+ETSTNP+ASIFAWTR LAHRA++DNN L F LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALE 360
Query: 360 DVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
+V I TIEAG MT+DLA CIKG NV R+DYLNT EF+D + + LK+ + ++K+
Sbjct: 361 EVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL 414
>emb|CAQ15240.1| isocitrate dehydrogenase 1 (NADP+), soluble [Danio rerio]
Length = 429
Score = 579 bits (1493), Expect = e-163, Method: Composition-based stats.
Identities = 270/409 (66%), Positives = 327/409 (79%), Gaps = 1/409 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M++ G +VE+ GDEMTRVIW+ IKE LIFP++ + + YDL MENRD T+D+VTVEA
Sbjct: 15 MSQKIKAGSVVEMQGDEMTRVIWELIKEKLIFPYLELDLHSYDLGMENRDATDDKVTVEA 74
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A A++++ VG+KCATITPDE RV+EF LK+MWRSPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 75 AEAVRRYNVGIKCATITPDEKRVEEFKLKQMWRSPNGTIRNILGGTVFREAIICKNIPRL 134
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYK-SGGVMM 179
V W KP++IGRHA GDQY ATD VV PGT EM + P NGGE + V D++ +GGV +
Sbjct: 135 VPGWIKPIIIGRHAHGDQYKATDFVVPGPGTVEMTYKPKNGGETLKFVVHDFEGTGGVAL 194
Query: 180 GMYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFK 239
GMYNTD SIRDFA S F+ L + WP+YLSTKNTILK YDGRFKDIF E+Y Y+ K++
Sbjct: 195 GMYNTDKSIRDFAHSSFQMGLNKGWPMYLSTKNTILKKYDGRFKDIFQEIYDKEYKAKYE 254
Query: 240 TCGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDG 299
GI+YEHRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDG
Sbjct: 255 AMGIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG 314
Query: 300 KTVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLE 359
+TVE EAAHGTVTRHYR +Q+GKETSTNP+ASIFAWTR L HRA +D N L F + LE
Sbjct: 315 RTVEAEAAHGTVTRHYRMHQQGKETSTNPIASIFAWTRGLLHRAELDKNAELRVFAEALE 374
Query: 360 DVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAM 408
V + TIEAG MT+DLAICIKG V R+DYLNT EF+D +++ LK+ +
Sbjct: 375 VVCVETIEAGFMTKDLAICIKGMSGVTRSDYLNTFEFLDKLAENLKIKL 423
>ref|XP_001176537.1| PREDICTED: similar to Isocitrate dehydrogenase 2 (NADP+),
mitochondrial [Strongylocentrotus purpuratus]
ref|XP_785580.2| PREDICTED: similar to Isocitrate dehydrogenase 2 (NADP+),
mitochondrial [Strongylocentrotus purpuratus]
Length = 449
Score = 579 bits (1492), Expect = e-163, Method: Composition-based stats.
Identities = 266/407 (65%), Positives = 324/407 (79%)
Query: 3 KISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEAAY 62
+I +VELDGDEMTRVIW+KIKETLIFP++NV YYDL + RD+T D+VTV+AA
Sbjct: 43 RIEVAKPVVELDGDEMTRVIWEKIKETLIFPYLNVECLYYDLGLPYRDQTNDQVTVDAAV 102
Query: 63 AIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRLVT 122
AIK+H VG+KCATITPDE RV EFNLK+MW+SPNGT+R ILGGTVFREPI+C +PRLV
Sbjct: 103 AIKEHNVGIKCATITPDEERVVEFNLKEMWKSPNGTLRNILGGTVFREPILCDTIPRLVP 162
Query: 123 TWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGGVMMGMY 182
W K + IGRHAFGDQY ATD V+KEPG FE+ F PA+G EP +VF++ GG M MY
Sbjct: 163 GWTKAITIGRHAFGDQYRATDMVIKEPGKFELVFSPASGAEPTRTEVFNFPGGGCGMAMY 222
Query: 183 NTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKTCG 242
NTD+SI FA SCF++ALA+KWPLYLSTKNTILK YDGRFKDIF E++ A Y+ + + G
Sbjct: 223 NTDESITGFAHSCFQYALAKKWPLYLSTKNTILKRYDGRFKDIFEEIFVANYKKDYDSAG 282
Query: 243 IFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGKTV 302
I+YEHRLIDDMVA ++S G +VWACKNYDGDVQSD +AQG+GSLG+MTS+LM PDGKT+
Sbjct: 283 IWYEHRLIDDMVAQALKSSGEFVWACKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTI 342
Query: 303 EVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLEDVI 362
E EAAHGTVTRH+R++QKG TSTNP+ASIFAWTR L HRA++DNN L F LE V
Sbjct: 343 ESEAAHGTVTRHFREHQKGNATSTNPIASIFAWTRGLEHRAKLDNNPDLKHFCTTLEKVC 402
Query: 363 IATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQ 409
+ T+++G MT+DLA CI G KNV YLNT +F++A+S L A++
Sbjct: 403 VDTVDSGMMTKDLAGCIHGLKNVKPEHYLNTMDFLNAISVNLDKALK 449
>emb|CAH89719.1| hypothetical protein [Pongo abelii]
Length = 414
Score = 578 bits (1491), Expect = e-163, Method: Composition-based stats.
Identities = 271/414 (65%), Positives = 332/414 (80%), Gaps = 1/414 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M+K + G +VE+ GDEMTR+IW++IKE LIFP+V + + YDL +ENRD T D+VT +A
Sbjct: 1 MSKKISGGSVVEMQGDEMTRIIWEQIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIKK+ VGVKCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 61 AEAIKKYNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGG-VMM 179
V+ W KP++IGRHA+GDQY ATD VV PG E+ + P++G + Y V +++ GG V M
Sbjct: 121 VSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAM 180
Query: 180 GMYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFK 239
GMYN D SI DFA S F+ AL++ WPLYLSTKNTILK YDGRFKDIF E+Y Y+++F+
Sbjct: 181 GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE 240
Query: 240 TCGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDG 299
I+YEHRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDG
Sbjct: 241 ARKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG 300
Query: 300 KTVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLE 359
KTVE EAAHGTVTRHYR YQKG+ETSTNP+ASIFAWTR LAHRA++DNN L F LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALE 360
Query: 360 DVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
+V + TIEAG MT+DLA CIKG NV R+DYLNT EF+D + + LK+ + +K+
Sbjct: 361 EVSVETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLALAKL 414
>sp|Q5R9C5|IDHC_PONPY Isocitrate dehydrogenase [NADP] cytoplasmic (Cytosolic
NADP-isocitrate dehydrogenase) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP)
Length = 414
Score = 578 bits (1491), Expect = e-163, Method: Composition-based stats.
Identities = 271/414 (65%), Positives = 332/414 (80%), Gaps = 1/414 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M+K + G +VE+ GDEMTR+IW+ IKE LIFP+V + + YDL +ENRD T D+VT +A
Sbjct: 1 MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIKK+ VGVKCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 61 AEAIKKYNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGG-VMM 179
V+ W KP++IGRHA+GDQY ATD VV PG E+ + P++G + Y V +++ GG V M
Sbjct: 121 VSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAM 180
Query: 180 GMYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFK 239
GMYN D SI DFA S F+ AL++ WPLYLSTKNTILK YDGRFKDIF E+Y Y+++F+
Sbjct: 181 GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE 240
Query: 240 TCGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDG 299
I+YEHRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDG
Sbjct: 241 ARKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG 300
Query: 300 KTVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLE 359
KTVE EAAHGTVTRHYR YQKG+ETSTNP+ASIFAWTR LAHRA++DNN L F LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALE 360
Query: 360 DVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
+V + TIEAG MT+DLA CIKG NV R+DYLNT EF+D + + LK+ + ++K+
Sbjct: 361 EVSVETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL 414
>emb|CAB66637.1| hypothetical protein [Homo sapiens]
emb|CAL37490.1| hypothetical protein [synthetic construct]
Length = 414
Score = 578 bits (1491), Expect = e-163, Method: Composition-based stats.
Identities = 271/414 (65%), Positives = 331/414 (79%), Gaps = 1/414 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M+K + G +VE+ GDEMTR+IW+ IKE LI P+V + + YDL +ENRD T D+VT +A
Sbjct: 1 MSKKISGGSVVEMQGDEMTRIIWELIKEKLIIPYVELDLHSYDLGIENRDATNDQVTKDA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIKKH VGVKCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 61 AEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGG-VMM 179
V+ W +P++IGRHA+GDQY ATD VV PG E+ + P++G + Y V +++ GG V M
Sbjct: 121 VSGWVEPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAM 180
Query: 180 GMYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFK 239
GMYN D SI DFA S F+ AL++ WPLYLSTKNTILK YDGRFKDIF E+Y Y+++F+
Sbjct: 181 GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE 240
Query: 240 TCGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDG 299
I+YEHRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDG
Sbjct: 241 AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG 300
Query: 300 KTVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLE 359
KTVE EAAHGTVTRHYR YQKG+ETSTNP+ASIFAWTR LAHRA++DNN L F LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALE 360
Query: 360 DVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
+V I TIEAG MT+DLA CIKG NV R+DYLNT EF+D + + LK+ + ++K+
Sbjct: 361 EVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL 414
>emb|CAG02627.1| unnamed protein product [Tetraodon nigroviridis]
Length = 410
Score = 578 bits (1490), Expect = e-163, Method: Composition-based stats.
Identities = 273/407 (67%), Positives = 331/407 (81%), Gaps = 3/407 (0%)
Query: 3 KISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEAAY 62
KI A G +VE+ GDEMTRVIW+ IK+ LIFP++++ + YDL +E RD T+DRVTVEAA
Sbjct: 4 KIRA-GSVVEMQGDEMTRVIWELIKDKLIFPYLDLDLHSYDLGIEYRDATDDRVTVEAAE 62
Query: 63 AIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRLVT 122
A++++ VG+KCATITPDE RV+EF LK+MWRSPNGTIR ILGGTVFRE IIC N+PRLV
Sbjct: 63 AVQRYNVGIKCATITPDEKRVEEFKLKQMWRSPNGTIRNILGGTVFREAIICRNIPRLVP 122
Query: 123 TWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYK-SGGVMMGM 181
W KP++IGRHA GDQY ATD VV EPG EM + P +G P Y ++++K SGGV MGM
Sbjct: 123 GWTKPIIIGRHAHGDQYKATDFVVPEPGKVEMIYTPTSG-TPTKYTIYEFKGSGGVAMGM 181
Query: 182 YNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKTC 241
YNTD SI+DFA S F+ AL++ WPLYLSTKNTILK YDGRFKDIF E+Y+ Y + FK
Sbjct: 182 YNTDKSIQDFAHSSFQLALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYEKEYISHFKDR 241
Query: 242 GIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGKT 301
GI+YEHRLIDDMVA M+S+GG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDG+T
Sbjct: 242 GIWYEHRLIDDMVAQAMKSDGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGRT 301
Query: 302 VEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLEDV 361
VE EAAHGTVTRHYR +Q+GKETSTNP+ASIFAWTR L HRA++D+N L F + LE V
Sbjct: 302 VESEAAHGTVTRHYRQHQEGKETSTNPIASIFAWTRGLLHRAKLDSNAELKSFCEALEAV 361
Query: 362 IIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAM 408
I TIE G MT+DLAICIKG +V RADYLNT EF+D +++ LKV +
Sbjct: 362 CIETIEGGFMTKDLAICIKGLAHVTRADYLNTFEFLDKLAENLKVKL 408
>ref|NP_113698.1| isocitrate dehydrogenase 1 (NADP+), soluble [Rattus norvegicus]
sp|P41562|IDHC_RAT Isocitrate dehydrogenase [NADP] cytoplasmic (Cytosolic
NADP-isocitrate dehydrogenase) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP)
gb|AAA59356.1| cytosolic NADP-dependent isocitrate dehydrogenase
gb|EDL98861.1| isocitrate dehydrogenase 1 (NADP+), soluble, isoform CRA_a [Rattus
norvegicus]
gb|EDL98863.1| isocitrate dehydrogenase 1 (NADP+), soluble, isoform CRA_a [Rattus
norvegicus]
gb|EDL98864.1| isocitrate dehydrogenase 1 (NADP+), soluble, isoform CRA_a [Rattus
norvegicus]
gb|EDL98865.1| isocitrate dehydrogenase 1 (NADP+), soluble, isoform CRA_a [Rattus
norvegicus]
Length = 414
Score = 578 bits (1489), Expect = e-163, Method: Composition-based stats.
Identities = 271/407 (66%), Positives = 325/407 (79%), Gaps = 1/407 (0%)
Query: 8 GVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEAAYAIKKH 67
G +VE+ GDEMTR+IW+ IKE LI P+V + + YDL +ENRD T D+VT +AA AIKK+
Sbjct: 8 GSVVEMQGDEMTRIIWELIKEKLILPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKY 67
Query: 68 GVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRLVTTWKKP 127
VGVKCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRLVT W KP
Sbjct: 68 NVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVTGWVKP 127
Query: 128 VVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGG-VMMGMYNTDD 186
++IGRHA+GDQY ATD VV PG E+ + P +G + Y V D++ GG V MGMYN D
Sbjct: 128 IIIGRHAYGDQYRATDFVVPGPGKVEITYTPKDGSQKVTYLVHDFEEGGGVAMGMYNQDK 187
Query: 187 SIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKTCGIFYE 246
SI DFA S F+ AL++ WPLYLSTKNTILK YDGRFKDIF E+Y Y++KF+ I+YE
Sbjct: 188 SIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSKFEAQKIWYE 247
Query: 247 HRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGKTVEVEA 306
HRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDGKTVE EA
Sbjct: 248 HRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDGKTVEAEA 307
Query: 307 AHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLEDVIIATI 366
AHGTVTRHYR YQKG+ETSTNP+ASIFAW+R LAHRA++DNN L F LE+V I TI
Sbjct: 308 AHGTVTRHYRMYQKGQETSTNPIASIFAWSRGLAHRAKLDNNTELSFFANALEEVCIETI 367
Query: 367 EAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
EAG MT+DLA CIKG NV R+DYLNT EF+D + + LK + ++K+
Sbjct: 368 EAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKAKLAQAKL 414
>sp|O88844|IDHC_MOUSE Isocitrate dehydrogenase [NADP] cytoplasmic (Cytosolic
NADP-isocitrate dehydrogenase) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP)
gb|AAD02919.1| NADP-dependent isocitrate dehydrogenase [Mus musculus]
Length = 414
Score = 578 bits (1489), Expect = e-163, Method: Composition-based stats.
Identities = 272/414 (65%), Positives = 328/414 (79%), Gaps = 1/414 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M++ G +VE+ GDEMTR+IW+ IKE LI P+V + + YDL +ENRD T D+VT +A
Sbjct: 1 MSRKIQGGSVVEMQGDEMTRIIWELIKEKLILPYVELDLHSYDLGIENRDATNDQVTKDA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIKK+ VGVKCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 61 AEAIKKYNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGG-VMM 179
VT W KP++IGRHA+GDQY ATD VV PG E+ + P +G + Y V D++ GG V M
Sbjct: 121 VTGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPKDGTQKVTYMVHDFEEGGGVAM 180
Query: 180 GMYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFK 239
GMYN D SI DFA S F+ AL++ WPLYLSTKNTILK YDGRFKDIF E+Y Y+++F+
Sbjct: 181 GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKKYKSQFE 240
Query: 240 TCGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDG 299
I YEHRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDG
Sbjct: 241 AQNICYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDG 300
Query: 300 KTVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLE 359
KTVE EAAHGTVTRHYR YQKG+ETSTNP+ASIFAW+R LAHRA++DNN L F + LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWSRGLAHRAKLDNNTELSFFAKALE 360
Query: 360 DVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
DV I TIEAG MT+DLA CIKG NV R+DYLNT EF+D + + LK + ++K+
Sbjct: 361 DVCIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKAKLAQAKL 414
>sp|Q9Z2K9|IDHC_MICME Isocitrate dehydrogenase [NADP] cytoplasmic (Cytosolic
NADP-isocitrate dehydrogenase) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP)
gb|AAD02924.1| cytosolic NADP-dependent isocitrate dehydrogenase [Microtus
mexicanus]
Length = 414
Score = 577 bits (1488), Expect = e-163, Method: Composition-based stats.
Identities = 272/414 (65%), Positives = 328/414 (79%), Gaps = 1/414 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M+K G +VE+ GDEMTR+IW+ IKE LI P+V + + YDL +ENRD T D+VT +A
Sbjct: 1 MSKKIHGGSVVEMQGDEMTRIIWELIKEKLILPYVELDLHSYDLGIENRDATNDQVTKDA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIKK+ VGVKCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 61 AEAIKKYNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGG-VMM 179
VT W KP++IGRHA+GDQY ATD VV PG E+ F P +G + Y V ++ GG V M
Sbjct: 121 VTGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITFTPKDGSQKVTYLVHSFEEGGGVAM 180
Query: 180 GMYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFK 239
GMYN D SI DFA S F+ AL++ WPLYLSTKNTILK YDGRFKDIF E+Y Y+++F+
Sbjct: 181 GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE 240
Query: 240 TCGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDG 299
I+YEHRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDG
Sbjct: 241 AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDG 300
Query: 300 KTVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLE 359
KTVE EAAHGTVTRHYR +QKG+ETSTNP+ASIFAW+R LAHRAR+DNN L F + LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMHQKGQETSTNPIASIFAWSRGLAHRARLDNNTELSFFAKALE 360
Query: 360 DVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
+V I TIEAG MT+DLA CIKG NV R+DYLNT EF+D + + LK + ++K+
Sbjct: 361 EVCIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKAKLAQAKL 414
>gb|AAD02918.1| NADP-dependent isocitrate dehydrogenase [Homo sapiens]
Length = 414
Score = 577 bits (1487), Expect = e-163, Method: Composition-based stats.
Identities = 271/414 (65%), Positives = 331/414 (79%), Gaps = 1/414 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M+K + G +VE+ GDEMTR+IW+ IKE LIFP+V + + YDL +ENRD T D+VT +A
Sbjct: 1 MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIKKH VGVKCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 61 AEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGG-VMM 179
V+ W KP++IGRHA+GDQY ATD VV PG E+ + P++G + Y V +++ GG V M
Sbjct: 121 VSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAM 180
Query: 180 GMYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFK 239
GMYN D SI DFA S F+ AL++ WPLYLSTKNTILK YDGRFKDIF E+Y Y+++F+
Sbjct: 181 GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKIYDGRFKDIFQEIYDKQYKSQFE 240
Query: 240 TCGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDG 299
I+YEHRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDG
Sbjct: 241 AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG 300
Query: 300 KTVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLE 359
KTVE EAAHGTVTRHYR YQKG+ETSTN +ASIFAWTR LAHRA++DNN L F LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMYQKGQETSTNLIASIFAWTRGLAHRAKLDNNKELAFFANALE 360
Query: 360 DVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
+V I TIEAG MT+DLA CI+G NV R+DYLNT EF+D + + LK+ + ++K+
Sbjct: 361 EVSIETIEAGFMTKDLAACIRGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL 414
>pdb|2CMJ|A Chain A, Crystal Structure Of Mouse Cytosolic Isocitrate
Dehydrogenase
pdb|2CMJ|B Chain B, Crystal Structure Of Mouse Cytosolic Isocitrate
Dehydrogenase
pdb|2CMV|A Chain A, Crystal Structure Of Mouse Cytosolic Isocitrate
Dehydrogenase Complexed With Cadmium And Citrate
pdb|2CMV|B Chain B, Crystal Structure Of Mouse Cytosolic Isocitrate
Dehydrogenase Complexed With Cadmium And Citrate
Length = 410
Score = 577 bits (1487), Expect = e-163, Method: Composition-based stats.
Identities = 271/406 (66%), Positives = 324/406 (79%), Gaps = 1/406 (0%)
Query: 8 GVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEAAYAIKKH 67
G +VE+ GDEMTR+IW+ IKE LI P+V + + YDL +ENRD T D+VT +AA AIKK+
Sbjct: 5 GSVVEMQGDEMTRIIWELIKEKLILPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKY 64
Query: 68 GVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRLVTTWKKP 127
VGVKCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRLVT W KP
Sbjct: 65 NVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVTGWVKP 124
Query: 128 VVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGG-VMMGMYNTDD 186
++IGRHA+GDQY ATD VV PG E+ + P +G + Y V D++ GG V MGMYN D
Sbjct: 125 IIIGRHAYGDQYRATDFVVPGPGKVEITYTPKDGTQKVTYMVHDFEEGGGVAMGMYNQDK 184
Query: 187 SIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKTCGIFYE 246
SI DFA S F+ AL++ WPLYLSTKNTILK YDGRFKDIF E+Y Y+++F+ I YE
Sbjct: 185 SIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKKYKSQFEAQNICYE 244
Query: 247 HRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGKTVEVEA 306
HRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDGKTVE EA
Sbjct: 245 HRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDGKTVEAEA 304
Query: 307 AHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLEDVIIATI 366
AHGTVTRHYR YQKG+ETSTNP+ASIFAW+R LAHRA++DNN L F + LEDV I TI
Sbjct: 305 AHGTVTRHYRMYQKGQETSTNPIASIFAWSRGLAHRAKLDNNTELSFFAKALEDVCIETI 364
Query: 367 EAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSK 412
EAG MT+DLA CIKG NV R+DYLNT EF+D + + LK + ++K
Sbjct: 365 EAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKAKLAQAK 410
>ref|NP_034627.3| isocitrate dehydrogenase 1 (NADP+), soluble [Mus musculus]
ref|NP_001104790.1| isocitrate dehydrogenase 1 (NADP+), soluble [Mus musculus]
dbj|BAE36075.1| unnamed protein product [Mus musculus]
dbj|BAE30207.1| unnamed protein product [Mus musculus]
dbj|BAE39299.1| unnamed protein product [Mus musculus]
dbj|BAE34873.1| unnamed protein product [Mus musculus]
dbj|BAE28720.1| unnamed protein product [Mus musculus]
gb|EDL00223.1| isocitrate dehydrogenase 1 (NADP+), soluble, isoform CRA_a [Mus
musculus]
gb|EDL00225.1| isocitrate dehydrogenase 1 (NADP+), soluble, isoform CRA_a [Mus
musculus]
Length = 414
Score = 577 bits (1487), Expect = e-163, Method: Composition-based stats.
Identities = 272/414 (65%), Positives = 328/414 (79%), Gaps = 1/414 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M++ G +VE+ GDEMTR+IW+ IKE LI P+V + + YDL +ENRD T D+VT +A
Sbjct: 1 MSRKIQGGSVVEMQGDEMTRIIWELIKEKLILPYVELDLHSYDLGIENRDATNDQVTKDA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIKK+ VGVKCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 61 AEAIKKYNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGG-VMM 179
VT W KP++IGRHA+GDQY ATD VV PG E+ + P +G + Y V D++ GG V M
Sbjct: 121 VTGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPKDGTQKVTYMVHDFEEGGGVAM 180
Query: 180 GMYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFK 239
GMYN D SI DFA S F+ AL++ WPLYLSTKNTILK YDGRFKDIF E+Y Y+++F+
Sbjct: 181 GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKKYKSQFE 240
Query: 240 TCGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDG 299
I YEHRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDG
Sbjct: 241 AQKICYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDG 300
Query: 300 KTVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLE 359
KTVE EAAHGTVTRHYR YQKG+ETSTNP+ASIFAW+R LAHRA++DNN L F + LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWSRGLAHRAKLDNNTELSFFAKALE 360
Query: 360 DVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
DV I TIEAG MT+DLA CIKG NV R+DYLNT EF+D + + LK + ++K+
Sbjct: 361 DVCIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKAKLAQAKL 414
>dbj|BAE39644.1| unnamed protein product [Mus musculus]
Length = 414
Score = 577 bits (1486), Expect = e-163, Method: Composition-based stats.
Identities = 272/414 (65%), Positives = 328/414 (79%), Gaps = 1/414 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M++ G +VE+ GDEMTR+IW+ IKE LI P+V + + YDL +ENRD T D+VT +A
Sbjct: 1 MSRKIKGGSVVEMQGDEMTRIIWELIKEKLILPYVELDLHSYDLGIENRDATNDQVTKDA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIKK+ VGVKCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 61 AEAIKKYNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGG-VMM 179
VT W KP++IGRHA+GDQY ATD VV PG E+ + P +G + Y V D++ GG V M
Sbjct: 121 VTGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPKDGTQKVTYMVHDFEEGGGVAM 180
Query: 180 GMYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFK 239
GMYN D SI DFA S F+ AL++ WPLYLSTKNTILK YDGRFKDIF E+Y Y+++F+
Sbjct: 181 GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKKYKSQFE 240
Query: 240 TCGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDG 299
I YEHRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDG
Sbjct: 241 AQKICYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDG 300
Query: 300 KTVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLE 359
KTVE EAAHGTVTRHYR YQKG+ETSTNP+ASIFAW+R LAHRA++DNN L F + LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWSRGLAHRAKLDNNTELSFFAKALE 360
Query: 360 DVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
DV I TIEAG MT+DLA CIKG NV R+DYLNT EF+D + + LK + ++K+
Sbjct: 361 DVCIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKAKLAQAKL 414
>ref|XP_001633903.1| predicted protein [Nematostella vectensis]
gb|EDO41840.1| predicted protein [Nematostella vectensis]
Length = 411
Score = 576 bits (1485), Expect = e-163, Method: Composition-based stats.
Identities = 273/405 (67%), Positives = 333/405 (82%), Gaps = 2/405 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M KI A G +VE+ GDEMTR+IW+ IKE LIFP+V++ ++ YDLS+ENRD T D+VT++A
Sbjct: 1 MAKIKA-GPVVEMQGDEMTRIIWELIKEKLIFPYVDMELKSYDLSIENRDATNDQVTIDA 59
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIK+ VG+KCATITPDE RV+EF LKKMW+SPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 60 AAAIKQCHVGIKCATITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICKNIPRL 119
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGG-VMM 179
V+ W KP++IGRHA DQY ATD VV PG E+ + PA+GGEP Y V ++K GG V M
Sbjct: 120 VSPWTKPIIIGRHAHADQYKATDFVVPGPGKVEIVYSPADGGEPIKYTVNEFKDGGGVTM 179
Query: 180 GMYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFK 239
GM+NTD SIR FA S F++AL +K+PLY+STKNTILK YDGRFKDIF E+Y+ Y++KF+
Sbjct: 180 GMFNTDVSIRAFAHSSFQYALDKKYPLYMSTKNTILKKYDGRFKDIFQEIYEQEYKSKFE 239
Query: 240 TCGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDG 299
I+YEHRLIDDMVA +++EGG++WACKNYDGDVQSDS+AQGFGSLGMMTS+L+ PDG
Sbjct: 240 ESNIWYEHRLIDDMVAFALKTEGGFIWACKNYDGDVQSDSVAQGFGSLGMMTSVLVCPDG 299
Query: 300 KTVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLE 359
KTVE EAAHGTVTRHYR +Q+GKETSTNPVASIFAWTR L HRA++D+N LL++ + LE
Sbjct: 300 KTVESEAAHGTVTRHYRMHQQGKETSTNPVASIFAWTRGLMHRAKLDDNAALLDYCKNLE 359
Query: 360 DVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRL 404
V I TIE+GAMT+DLA CIKG NV R DYLNT EF+D +++ L
Sbjct: 360 AVCIETIESGAMTKDLAGCIKGISNVTRPDYLNTFEFLDKIAENL 404
>emb|CAG38553.1| IDH1 [Homo sapiens]
Length = 414
Score = 576 bits (1485), Expect = e-163, Method: Composition-based stats.
Identities = 270/414 (65%), Positives = 330/414 (79%), Gaps = 1/414 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M+K + G +VE+ GDEMTR+IW+ IKE LI P+V + + YDL +ENRD T D+VT +A
Sbjct: 1 MSKKISGGSVVEMQGDEMTRIIWELIKEKLIIPYVELDLHSYDLGIENRDATNDQVTKDA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIKKH VGVKCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 61 AEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGG-VMM 179
V+ W +P++IGRHA+GDQY ATD VV PG E+ + P++G + Y V +++ GG V M
Sbjct: 121 VSGWVEPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAM 180
Query: 180 GMYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFK 239
GMYN D SI DFA S F+ AL++ WPLYLSTKNTILK YDGRFKDIF E+Y Y+++F+
Sbjct: 181 GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE 240
Query: 240 TCGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDG 299
I+YEHRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDG
Sbjct: 241 AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG 300
Query: 300 KTVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLE 359
KTVE EAAHGTVTRHYR YQKG+ETSTNP+ASIFAWTR LAHRA++DNN L F LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALE 360
Query: 360 DVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
+V I TIEAG MT+ LA CIKG NV R+DYLNT EF+D + + LK+ + ++K+
Sbjct: 361 EVSIETIEAGFMTKGLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL 414
>dbj|BAC39792.1| unnamed protein product [Mus musculus]
Length = 422
Score = 576 bits (1485), Expect = e-162, Method: Composition-based stats.
Identities = 271/413 (65%), Positives = 327/413 (79%), Gaps = 1/413 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M++ G +VE+ GDEMTR+IW+ IKE LI P+V + + YDL +ENRD T D+VT +A
Sbjct: 1 MSRKIQGGSVVEMQGDEMTRIIWELIKEKLILPYVELDLHSYDLGIENRDATNDQVTKDA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIKK+ VGVKCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 61 AEAIKKYNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGG-VMM 179
VT W KP++IGRHA+GDQY ATD VV PG E+ + P +G + Y V D++ GG V M
Sbjct: 121 VTGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPKDGTQKVTYMVHDFEEGGGVAM 180
Query: 180 GMYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFK 239
GMYN D SI DFA S F+ AL++ WPLYLSTKNTILK YDGRFKDIF E+Y Y+++F+
Sbjct: 181 GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKKYKSQFE 240
Query: 240 TCGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDG 299
I YEHRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDG
Sbjct: 241 AQKICYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDG 300
Query: 300 KTVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLE 359
KTVE EAAHGTVTRHYR YQKG+ETSTNP+ASIFAW+R LAHRA++DNN L F + LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWSRGLAHRAKLDNNTELSFFAKALE 360
Query: 360 DVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSK 412
DV I TIEAG MT+DLA CIKG NV R+DYLNT EF+D + + LK + +++
Sbjct: 361 DVCIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKAKLAQAQ 413
>gb|AAH88986.1| Isocitrate dehydrogenase 1 (NADP+), soluble [Mus musculus]
Length = 414
Score = 576 bits (1484), Expect = e-162, Method: Composition-based stats.
Identities = 271/414 (65%), Positives = 328/414 (79%), Gaps = 1/414 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M++ G +VE+ GDEMTR+IW+ IKE LI P+V + + YDL +ENRD T D+VT +A
Sbjct: 1 MSRKIQGGSVVEMQGDEMTRIIWELIKEKLILPYVELDLHSYDLGIENRDATNDQVTKDA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A A+KK+ VGVKCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 61 AEALKKYNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGG-VMM 179
VT W KP++IGRHA+GDQY ATD VV PG E+ + P +G + Y V D++ GG V M
Sbjct: 121 VTGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPKDGTQKVTYMVHDFEEGGGVAM 180
Query: 180 GMYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFK 239
GMYN D SI DFA S F+ AL++ WPLYLSTKNTILK YDGRFKDIF E+Y Y+++F+
Sbjct: 181 GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKKYKSQFE 240
Query: 240 TCGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDG 299
I YEHRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDG
Sbjct: 241 AQKICYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDG 300
Query: 300 KTVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLE 359
KTVE EAAHGTVTRHYR YQKG+ETSTNP+ASIFAW+R LAHRA++DNN L F + LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWSRGLAHRAKLDNNTELSFFAKALE 360
Query: 360 DVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
DV I TIEAG MT+DLA CIKG NV R+DYLNT EF+D + + LK + ++K+
Sbjct: 361 DVCIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKAKLAQAKL 414
>sp|Q9Z2K8|IDHC_MICOH Isocitrate dehydrogenase [NADP] cytoplasmic (Cytosolic
NADP-isocitrate dehydrogenase) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP)
gb|AAD02925.1| cytosolic NADP-dependent isocitrate dehydrogenase [Microtus
ochrogaster]
Length = 414
Score = 576 bits (1484), Expect = e-162, Method: Composition-based stats.
Identities = 271/414 (65%), Positives = 328/414 (79%), Gaps = 1/414 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M+K G +VE+ GDEMTR+IW+ IKE LI P+V + + YDL +ENRD T D+VT +A
Sbjct: 1 MSKKIHGGSVVEMQGDEMTRIIWELIKEKLILPYVELDLHSYDLGIENRDATNDQVTKDA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIKK+ VGVKCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 61 AEAIKKYNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGG-VMM 179
VT W KP++IGRHA+GDQY ATD VV PG E+ + P +G + Y V ++ GG V M
Sbjct: 121 VTGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPKDGSQKVTYLVHSFEEGGGVAM 180
Query: 180 GMYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFK 239
GMYN D SI DFA S F+ AL++ WPLYLSTKNTILK YDGRFKDIF E+Y Y+++F+
Sbjct: 181 GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE 240
Query: 240 TCGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDG 299
I+YEHRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDG
Sbjct: 241 AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDG 300
Query: 300 KTVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLE 359
KTVE EAAHGTVTRHYR +QKG+ETSTNP+ASIFAW+R LAHRAR+DNN L F + LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMHQKGQETSTNPIASIFAWSRGLAHRARLDNNTELSFFAKALE 360
Query: 360 DVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
+V I TIEAG MT+DLA CIKG NV R+DYLNT EF+D + + LK + ++K+
Sbjct: 361 EVCIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKAKLAQAKL 414
>ref|XP_780121.1| PREDICTED: similar to cytosolic NADP-dependent isocitrate
dehydrogenase isoform 1 [Strongylocentrotus purpuratus]
ref|XP_001176835.1| PREDICTED: similar to cytosolic NADP-dependent isocitrate
dehydrogenase [Strongylocentrotus purpuratus]
Length = 409
Score = 575 bits (1483), Expect = e-162, Method: Composition-based stats.
Identities = 272/403 (67%), Positives = 325/403 (80%), Gaps = 2/403 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M+KI G +VE+ GDEMTR+IW IK+ LI PF+++ I+ YDLS++NRD T+D+VTVE
Sbjct: 1 MSKIQG-GTVVEMQGDEMTRIIWDDIKKKLILPFIDLNIQSYDLSIQNRDATDDKVTVEC 59
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIKK VG+KCATITPDE RV+EFNLKKMW+SPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 60 AEAIKKCNVGIKCATITPDEKRVEEFNLKKMWKSPNGTIRNILGGTVFREAIICKNIPRL 119
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGG-VMM 179
V TW KP+VIGRHA DQY ATD VV G EM+F PA+G EP+ + + D+K GG V M
Sbjct: 120 VVTWNKPIVIGRHAHADQYLATDLVVPGKGKMEMKFTPADGSEPQTFTIHDFKDGGGVAM 179
Query: 180 GMYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFK 239
GM+NTD SI +FA CF F+L R +PLYLSTKNTILK YDGRFKDIF E+Y+ Y ++
Sbjct: 180 GMFNTDVSITNFAHCCFRFSLDRGYPLYLSTKNTILKRYDGRFKDIFQEIYEKEYRADYE 239
Query: 240 TCGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDG 299
I+YEHRLIDDMVA M++EGG+VWACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDG
Sbjct: 240 AKNIWYEHRLIDDMVAFAMKNEGGFVWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG 299
Query: 300 KTVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLE 359
KTVE EAAHGTVTRHYR +Q+GKETSTN VASIFAWTR LAHRA++D+N L +F+ LE
Sbjct: 300 KTVESEAAHGTVTRHYRMHQQGKETSTNSVASIFAWTRGLAHRAKLDSNEALAKFSTALE 359
Query: 360 DVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQ 402
+ I TIE G MT+DLAICIKG NV RADY+NT EFI+ V++
Sbjct: 360 EACIETIEGGTMTKDLAICIKGMANVTRADYVNTFEFIEKVAE 402
>ref|XP_860853.1| PREDICTED: similar to Isocitrate dehydrogenase [NADP] cytoplasmic
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) (IDP) isoform 5 [Canis familiaris]
Length = 408
Score = 575 bits (1482), Expect = e-162, Method: Composition-based stats.
Identities = 268/406 (66%), Positives = 324/406 (79%), Gaps = 5/406 (1%)
Query: 8 GVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEAAYAIKKH 67
G +VE+ GDEMTR+IW+ IKE LIFP+V + + YDL +ENRD T D+VT +AA AIKK+
Sbjct: 8 GSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKY 67
Query: 68 GVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRLVTTWKKP 127
VGVKCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRLV+ W KP
Sbjct: 68 NVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKP 127
Query: 128 VVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGGVMMGMYNTDDS 187
++IGRHA+GDQY ATD VV PG E+ + P++G E Y GGV MGMYN D S
Sbjct: 128 IIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGSEK-----MTYLGGGVAMGMYNQDKS 182
Query: 188 IRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKTCGIFYEH 247
I DFA S F+ AL++ WPLYLSTKNTILK YDGRFKDIF E+Y Y+++F+ I+YEH
Sbjct: 183 IEDFAHSSFQMALSKSWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQNIWYEH 242
Query: 248 RLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGKTVEVEAA 307
RLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDGKTVE EAA
Sbjct: 243 RLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAA 302
Query: 308 HGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLEDVIIATIE 367
HGTVTRHYR YQKG+ETSTNP+ASIFAWTR LAHRA++DNN L F + LE+V + TIE
Sbjct: 303 HGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELSFFAKALEEVCVETIE 362
Query: 368 AGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
AG MT+DLA CIKG NV R+DYLNT EF+D + + L + + ++K+
Sbjct: 363 AGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLNIKLAQAKL 408
>emb|CAH91635.1| hypothetical protein [Pongo abelii]
Length = 414
Score = 574 bits (1480), Expect = e-162, Method: Composition-based stats.
Identities = 269/414 (64%), Positives = 330/414 (79%), Gaps = 1/414 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M+K + G +VE+ GDEMTR+IW+ IKE LIFP+V + + YDL +ENRD T D+VT +A
Sbjct: 1 MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIKK+ VGVKCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 61 AEAIKKYNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGG-VMM 179
V+ W KP++IGRHA+GDQY ATD VV PG E+ + P++G + Y V +++ GG V M
Sbjct: 121 VSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAM 180
Query: 180 GMYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFK 239
GMYN D SI DFA S F+ AL++ WPLYLSTKNTILK YDGRFKD F E+Y Y+++F+
Sbjct: 181 GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDTFQEIYDKQYKSQFE 240
Query: 240 TCGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDG 299
I+YEHRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDG
Sbjct: 241 ARKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG 300
Query: 300 KTVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLE 359
KTVE EAAHGTVTRHYR YQKG+ETSTNP+ SIFAWTR LAHRA++DNN L F LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMYQKGQETSTNPIVSIFAWTRGLAHRAKLDNNKELAFFANALE 360
Query: 360 DVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
+V + TIEAG MT+DLA CIKG NV R+DYLNT EF+D + + LK+ + ++K+
Sbjct: 361 EVSVETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL 414
>gb|AAV33246.1| isocitrate dehydrogenase [Toxoplasma gondii]
Length = 594
Score = 573 bits (1476), Expect = e-161, Method: Composition-based stats.
Identities = 256/400 (64%), Positives = 325/400 (81%), Gaps = 1/400 (0%)
Query: 3 KISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEAAY 62
+I +VE+DGDEM RVIW IKE LI P++++P+ YYDLS+++RDKT+D+VT++AA
Sbjct: 181 RIKVDQPVVEMDGDEMARVIWAMIKEKLILPYLDIPLMYYDLSIQHRDKTDDQVTIDAAL 240
Query: 63 AIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRLVT 122
AIK+HGVGVKCATITPDE RVKEFNLKKMW+SPN TIR L GT+FR PI+ NVPRLV
Sbjct: 241 AIKRHGVGVKCATITPDEQRVKEFNLKKMWKSPNATIRNTLDGTIFRAPILMKNVPRLVP 300
Query: 123 TWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGGVMMGMY 182
+W KP++IGRHA DQY A D V +PG F M FIPA+ P+V++V+++K GGV +GMY
Sbjct: 301 SWTKPIIIGRHAHADQYKALDFTVDKPGRFVMSFIPADKSNPEVHEVYEFKGGGVALGMY 360
Query: 183 NTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKTCG 242
NTD SI+ FA SCF++AL +K PLYLSTKNT+LK YDGRFKDIF +Y+ Y+ KF+ G
Sbjct: 361 NTDASIKGFAHSCFQYALDQKMPLYLSTKNTVLKKYDGRFKDIFQTIYEKEYKQKFEEAG 420
Query: 243 IFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGKTV 302
++YEHRLIDDMVA ++S GG+VWACKNYDGDVQSD +AQG+GSLG+MTS+L+ PDGKT+
Sbjct: 421 LWYEHRLIDDMVAQAIKSSGGFVWACKNYDGDVQSDVVAQGYGSLGLMTSVLVCPDGKTI 480
Query: 303 EVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLEDVI 362
E EAAHGTVTRHYR YQKG +TSTNP+ASI+AWTR+L HRA++DNN L EF + LED
Sbjct: 481 EAEAAHGTVTRHYRQYQKGIKTSTNPIASIYAWTRSLGHRAKLDNNQKLKEFVEALEDAC 540
Query: 363 IATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQ 402
+ T+EAG MT+DLA+ IKG+K R DYL T++F+D +++
Sbjct: 541 VETVEAGFMTKDLALAIKGDKLTDR-DYLCTEDFMDKLAR 579
>ref|XP_001365492.1| PREDICTED: similar to cytosolic NADP-dependent isocitrate
dehydrogenase [Monodelphis domestica]
Length = 414
Score = 572 bits (1474), Expect = e-161, Method: Composition-based stats.
Identities = 266/407 (65%), Positives = 328/407 (80%), Gaps = 1/407 (0%)
Query: 8 GVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEAAYAIKKH 67
G +VE+ GDEMTRVIW IK+ LIFP+VN+ + YDL +E+RD+T+D+VT++AA AIKK+
Sbjct: 8 GSVVEMQGDEMTRVIWDLIKQKLIFPYVNLDLHSYDLGIEHRDETDDQVTIDAAEAIKKY 67
Query: 68 GVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRLVTTWKKP 127
VG+KCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRLV W KP
Sbjct: 68 NVGIKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVNGWVKP 127
Query: 128 VVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKS-GGVMMGMYNTDD 186
+VIGRHA+GDQY ATD VV PG E+ + P +G + Y + +++ GGV MGMYN D
Sbjct: 128 IVIGRHAYGDQYRATDFVVPGPGKVEISYTPRDGSKTVTYLIHNFEDCGGVAMGMYNLDQ 187
Query: 187 SIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKTCGIFYE 246
SI DFA S F+ AL + WPLY+STKNTILK YDGRFKDIF ++Y Y++KF+ I+YE
Sbjct: 188 SIMDFAHSSFQMALTKGWPLYMSTKNTILKKYDGRFKDIFQKIYDTHYKSKFEAKKIWYE 247
Query: 247 HRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGKTVEVEA 306
HRLIDDMVA ++SEGG+VWACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDGKTVE EA
Sbjct: 248 HRLIDDMVAQALKSEGGFVWACKNYDGDVQSDSIAQGYGSLGMMTSVLICPDGKTVEAEA 307
Query: 307 AHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLEDVIIATI 366
AHGTVTRHYR YQKG+ETSTNP+ASIFAWTR LAHRA++D+N L F LE+V I TI
Sbjct: 308 AHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDDNKELGTFATILEEVCIETI 367
Query: 367 EAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
E+G MT+DLA CIKG NV R+DYLNT EF+D +++ LK + ++K+
Sbjct: 368 ESGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLAENLKAKLAQAKL 414
>ref|YP_872148.1| isocitrate dehydrogenase [Acidothermus cellulolyticus 11B]
gb|ABK52162.1| isocitrate dehydrogenase (NADP) [Acidothermus cellulolyticus 11B]
Length = 407
Score = 571 bits (1471), Expect = e-161, Method: Composition-based stats.
Identities = 259/411 (63%), Positives = 328/411 (79%), Gaps = 5/411 (1%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M KI +VELDGDEMTRVIW+ IKE L+FP++++P+ Y+DL +ENRD T+D+VT++A
Sbjct: 1 MPKIKVANPIVELDGDEMTRVIWRMIKEQLLFPYLDIPLLYFDLGIENRDATDDQVTIDA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
AYAIK+HGVGVKCATITPDEARV EF LKKMW+SPNGTIR ILGG +FREPII SN+PRL
Sbjct: 61 AYAIKEHGVGVKCATITPDEARVAEFGLKKMWKSPNGTIRNILGGVIFREPIIISNIPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGGVMMG 180
V +W KP+VIGRHA GDQY ATD VV PG + + PA+GG P ++V ++ GGV +G
Sbjct: 121 VPSWTKPIVIGRHAHGDQYRATDFVVPGPGRVTLTYTPADGGAPVEFEVAEFSGGGVALG 180
Query: 181 MYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKT 240
MYN D+SIRDFAR+CF + L R +P+YLSTKNTILK YDGRFKDIFAE++ +ET FK
Sbjct: 181 MYNYDESIRDFARACFRYGLDRGYPVYLSTKNTILKAYDGRFKDIFAEVFAQEFETAFKE 240
Query: 241 CGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGK 300
G+ YEHRLIDDMVA ++ EGGYVWACKNYDGDVQSD++AQGFGSLG+MTS+LMTPDG+
Sbjct: 241 AGLSYEHRLIDDMVASALKWEGGYVWACKNYDGDVQSDAVAQGFGSLGLMTSVLMTPDGR 300
Query: 301 TVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLED 360
TVE EAAHGTVTRH+R +Q+GK TSTNP+ASI+AWTR L HR ++D ++ F + LE+
Sbjct: 301 TVEAEAAHGTVTRHFRLHQQGKPTSTNPIASIYAWTRGLEHRGKLDGTPEVVRFARTLEE 360
Query: 361 VIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKS 411
V + T+E+G MT+DLA+ + E +L T+EF+ A+++ L+ A+ S
Sbjct: 361 VCVRTVESGKMTKDLAMLVGPE-----TPWLTTEEFLAALAENLQAALAAS 406
>ref|XP_968850.1| PREDICTED: similar to CG7176-PC, isoform C [Tribolium castaneum]
Length = 408
Score = 570 bits (1470), Expect = e-161, Method: Composition-based stats.
Identities = 271/408 (66%), Positives = 327/408 (80%), Gaps = 2/408 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M KI A G +V++ GDEMTR+IW IKE LI PF++V + YDL +ENRDKT D+VTV+
Sbjct: 1 MGKIKA-GPVVDILGDEMTRIIWDSIKEKLILPFLDVELHTYDLGIENRDKTSDQVTVDC 59
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIKK+ VG+KCATITPDE RV+EFNLK+MW+SPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 60 AEAIKKYNVGIKCATITPDEKRVEEFNLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 119
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGGVMMG 180
V+ W KP++IGRHA DQY ATD VV PG E+ F P +G +P + V +YK GV +G
Sbjct: 120 VSGWNKPIIIGRHAHADQYKATDFVVPGPGKLELVFTPISG-QPIKHIVNEYKGAGVALG 178
Query: 181 MYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKT 240
M+NTD+SI+DFA S F+FAL + +PLYLSTKNTILK YDGRFKDIF ++Y Y+ +F+
Sbjct: 179 MFNTDESIKDFAHSSFKFALNQGYPLYLSTKNTILKKYDGRFKDIFQDIYDREYKKQFEA 238
Query: 241 CGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGK 300
GI+YEHRLIDDMVA+ M+SEGG+VWACKNYDGDVQSDS+AQG+GSLG+MTS+L+ PDGK
Sbjct: 239 KGIWYEHRLIDDMVAYAMKSEGGFVWACKNYDGDVQSDSVAQGYGSLGLMTSVLICPDGK 298
Query: 301 TVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLED 360
TVE EAAHGTVTRHYR YQKG+ETSTNP+ASIFAWTR L HRA++DNN L +F LE
Sbjct: 299 TVESEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLLHRAKLDNNKELEKFANTLEK 358
Query: 361 VIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAM 408
V I TIE+G MT+DLAICIKG V R+DYL T EF+ ++ LK AM
Sbjct: 359 VCIDTIESGFMTKDLAICIKGMNGVKRSDYLETFEFMQKLADNLKKAM 406
>gb|ABO93633.1| isocitrate dehydrogenase 2 [Toxoplasma gondii]
Length = 621
Score = 570 bits (1470), Expect = e-161, Method: Composition-based stats.
Identities = 266/406 (65%), Positives = 318/406 (78%), Gaps = 1/406 (0%)
Query: 3 KISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEAAY 62
KI +VE+DGDEMTR++W IKE L+FP+V +P+EYYDLS+ NRD+TED+VT+EAA
Sbjct: 175 KIHVANPVVEMDGDEMTRILWAWIKEKLLFPYVEIPLEYYDLSVTNRDQTEDKVTLEAAE 234
Query: 63 AIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRLVT 122
AIKK VG+KCATITPDE RVKEFNLKKMW+SPNGTIR IL GTVFR PI+ SNVPRLV
Sbjct: 235 AIKKCHVGIKCATITPDEGRVKEFNLKKMWKSPNGTIRNILDGTVFRAPILISNVPRLVP 294
Query: 123 TWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGGVMMGMY 182
WKKP+VIGRHA+GDQY A V PG F + F PA GG KVF + GVM+GMY
Sbjct: 295 GWKKPIVIGRHAYGDQYKAESLVCDGPGDFTISFTPA-GGSRVEKKVFSFSGPGVMLGMY 353
Query: 183 NTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKTCG 242
NT+DSIR FA S F+FAL + PLYLSTKNTILK YDG FKDIF Y ++ F+ G
Sbjct: 354 NTEDSIRGFALSSFKFALQQNMPLYLSTKNTILKQYDGMFKDIFQSYYDEQFKPLFEKQG 413
Query: 243 IFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGKTV 302
I+YEHRLIDDMVA ++SEGG+VWACKNYDGDVQSD +AQG+GSLG+MTSIL+ PDGKTV
Sbjct: 414 IWYEHRLIDDMVAQALKSEGGFVWACKNYDGDVQSDIVAQGYGSLGLMTSILVCPDGKTV 473
Query: 303 EVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLEDVI 362
EAAHGTVTRHYR +QKG++TSTNP+ASIFAWTR LAHRA++D N+ L +F LE
Sbjct: 474 VSEAAHGTVTRHYRQHQKGQKTSTNPIASIFAWTRGLAHRAKLDGNDRLGQFCLALEHAC 533
Query: 363 IATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAM 408
I T+E GAM +DLA+C+KG V +DYL T+EF+DA+S LK+ +
Sbjct: 534 IQTVENGAMPKDLALCVKGADKVTASDYLTTEEFMDAISDTLKMNL 579
Searching..................................................done
Results from round 2
Score E
Sequences producing significant alignments: (bits) Value
Sequences used in model and found again:
ref|XP_536192.2| PREDICTED: similar to isocitrate dehydroge... 738 0.0
ref|NP_786984.1| isocitrate dehydrogenase 2 (NADP+), mitoch... 737 0.0
sp|Q04467|IDHP_BOVIN Isocitrate dehydrogenase [NADP], mitoc... 736 0.0
ref|NP_851355.2| isocitrate dehydrogenase 1 (NADP+), solubl... 736 0.0
ref|NP_001026770.1| hypothetical protein LOC431056 [Gallus ... 736 0.0
ref|XP_001369305.1| PREDICTED: hypothetical protein [Monode... 736 0.0
ref|XP_001107627.1| PREDICTED: isocitrate dehydrogenase 1 (... 736 0.0
sp|P54071|IDHP_MOUSE Isocitrate dehydrogenase [NADP], mitoc... 735 0.0
ref|NP_001009276.1| cytosolic NADP-isocitrate dehydrogenase... 735 0.0
sp|Q9Z2K9|IDHC_MICME Isocitrate dehydrogenase [NADP] cytopl... 735 0.0
ref|NP_766599.1| isocitrate dehydrogenase 2 (NADP+), mitoch... 734 0.0
sp|Q9Z2K8|IDHC_MICOH Isocitrate dehydrogenase [NADP] cytopl... 733 0.0
ref|NP_113698.1| isocitrate dehydrogenase 1 (NADP+), solubl... 733 0.0
sp|Q9XSG3|IDHC_BOVIN Isocitrate dehydrogenase [NADP] cytopl... 733 0.0
ref|XP_850187.1| PREDICTED: similar to Isocitrate dehydroge... 733 0.0
emb|CAG38738.1| IDH1 [Homo sapiens] 733 0.0
ref|NP_005887.2| isocitrate dehydrogenase 1 (NADP+), solubl... 733 0.0
sp|Q5R9C5|IDHC_PONPY Isocitrate dehydrogenase [NADP] cytopl... 733 0.0
ref|XP_421965.2| PREDICTED: similar to cytosolic NADP-depen... 733 0.0
ref|NP_970434.1| isocitrate dehydrogenase [Bdellovibrio bac... 732 0.0
gb|ABU41004.1| isocitrate dehydrogenase 1 [Anser anser] 732 0.0
gb|ABE98244.1| mitochondrial isocitrate dehydrogenase 2-lik... 732 0.0
ref|XP_001141655.1| PREDICTED: isocitrate dehydrogenase 1 (... 732 0.0
ref|XP_510589.2| PREDICTED: isocitrate dehydrogenase 2 (NAD... 731 0.0
ref|XP_860821.1| PREDICTED: similar to Isocitrate dehydroge... 731 0.0
ref|NP_001014183.1| isocitrate dehydrogenase 2 (NADP+), mit... 731 0.0
gb|AAH93020.1| Isocitrate dehydrogenase 1 (NADP+), soluble ... 731 0.0
emb|CAM77136.1| Isocitrate/isopropylmalate dehydrogenase [M... 731 0.0
ref|XP_001505172.1| PREDICTED: similar to Isocitrate dehydr... 731 0.0
pdb|1LWD|A Chain A, Crystal Structure Of Nadp-Dependent Iso... 731 0.0
ref|XP_001095686.1| PREDICTED: isocitrate dehydrogenase 2 (... 731 0.0
ref|NP_001088022.1| hypothetical protein LOC494713 [Xenopus... 730 0.0
emb|CAD97653.1| hypothetical protein [Homo sapiens] >gi|117... 730 0.0
sp|P33198|IDHP_PIG Isocitrate dehydrogenase [NADP], mitocho... 730 0.0
gb|ACO14046.1| Isocitrate dehydrogenase, mitochondrial prec... 730 0.0
emb|CAH89719.1| hypothetical protein [Pongo abelii] 730 0.0
ref|NP_002159.2| isocitrate dehydrogenase 2 (NADP+), mitoch... 730 0.0
ref|NP_955858.1| isocitrate dehydrogenase 2 (NADP+), mitoch... 730 0.0
emb|CAB66637.1| hypothetical protein [Homo sapiens] >gi|117... 729 0.0
sp|O88844|IDHC_MOUSE Isocitrate dehydrogenase [NADP] cytopl... 729 0.0
emb|CAA49208.1| isocitrate dehydrogenase (NADP+) [Homo sapi... 729 0.0
dbj|BAD96636.1| isocitrate dehydrogenase 2 (NADP+), mitocho... 729 0.0
emb|CAH91635.1| hypothetical protein [Pongo abelii] 728 0.0
ref|NP_034627.3| isocitrate dehydrogenase 1 (NADP+), solubl... 728 0.0
dbj|BAE39644.1| unnamed protein product [Mus musculus] 727 0.0
dbj|BAC39792.1| unnamed protein product [Mus musculus] 727 0.0
gb|AAH88986.1| Isocitrate dehydrogenase 1 (NADP+), soluble ... 727 0.0
ref|NP_539708.1| isocitrate dehydrogenase [Brucella meliten... 726 0.0
ref|XP_001168316.1| PREDICTED: isocitrate dehydrogenase 2 (... 726 0.0
gb|AAD02918.1| NADP-dependent isocitrate dehydrogenase [Hom... 726 0.0
gb|EAX02083.1| isocitrate dehydrogenase 2 (NADP+), mitochon... 726 0.0
emb|CAG38553.1| IDH1 [Homo sapiens] 726 0.0
ref|NP_698203.1| isocitrate dehydrogenase [Brucella suis 13... 726 0.0
ref|YP_677841.1| isocitrate dehydrogenase [Cytophaga hutchi... 725 0.0
dbj|BAC77065.1| NADP-specific isocitrate dehydrogenase [Lup... 725 0.0
ref|XP_001511049.1| PREDICTED: similar to cytosolic NADP-de... 724 0.0
pdb|2CMJ|A Chain A, Crystal Structure Of Mouse Cytosolic Is... 724 0.0
ref|NP_001080321.1| hypothetical protein LOC380013 [Xenopus... 724 0.0
ref|ZP_01885694.1| isocitrate dehydrogenase [Pedobacter sp.... 724 0.0
ref|XP_001688948.1| AGAP006660-PA [Anopheles gambiae str. P... 724 0.0
ref|XP_860853.1| PREDICTED: similar to Isocitrate dehydroge... 723 0.0
emb|CAG13105.1| unnamed protein product [Tetraodon nigrovir... 723 0.0
ref|XP_001168291.1| PREDICTED: isocitrate dehydrogenase 2 (... 722 0.0
ref|XP_001778805.1| predicted protein [Physcomitrella paten... 722 0.0
ref|XP_001633903.1| predicted protein [Nematostella vectens... 722 0.0
emb|CAG02362.1| unnamed protein product [Tetraodon nigrovir... 721 0.0
ref|ZP_02188085.1| Isocitrate dehydrogenase [alpha proteoba... 721 0.0
ref|XP_001365492.1| PREDICTED: similar to cytosolic NADP-de... 721 0.0
ref|NP_001004799.1| MGC69505 protein [Xenopus tropicalis] >... 720 0.0
emb|CAA53300.1| isocitrate dehydrogenase (NADP+) [Solanum t... 720 0.0
ref|YP_419971.1| isocitrate dehydrogenase [Magnetospirillum... 720 0.0
ref|YP_001370537.1| isocitrate dehydrogenase, NADP-dependen... 720 0.0
ref|NP_958907.1| isocitrate dehydrogenase 1 (NADP+), solubl... 718 0.0
emb|CAQ15240.1| isocitrate dehydrogenase 1 (NADP+), soluble... 718 0.0
ref|YP_673828.1| isocitrate dehydrogenase [Mesorhizobium sp... 718 0.0
gb|AAC64182.1| NADP-dependent isocitrate dehydrogenase [Gly... 718 0.0
ref|XP_001841910.1| isocitrate dehydrogenase cytoplasmic [C... 718 0.0
ref|XP_001698704.1| isocitrate dehydrogenase, NADP-dependen... 718 0.0
ref|YP_002826161.1| NADP isocitrate dehydrogenase [Rhizobiu... 717 0.0
ref|ZP_00056387.1| COG0538: Isocitrate dehydrogenases [Magn... 717 0.0
ref|NP_001056381.1| Os05g0573200 [Oryza sativa (japonica cu... 716 0.0
ref|YP_425448.1| isocitrate dehydrogenase [Rhodospirillum r... 716 0.0
ref|XP_001168261.1| PREDICTED: isocitrate dehydrogenase 2 (... 716 0.0
sp|P50218|IDHC_TOBAC Isocitrate dehydrogenase [NADP] (Oxalo... 716 0.0
ref|XP_821599.1| isocitrate dehydrogenase, putative [Trypan... 716 0.0
sp|Q40345|IDHP_MEDSA Isocitrate dehydrogenase [NADP], chlor... 715 0.0
ref|XP_001650675.1| nadp-specific isocitrate dehydrogenase ... 715 0.0
ref|ZP_03891012.1| isocitrate dehydrogenase (NADP) [Geoderm... 715 0.0
ref|NP_101923.1| isocitrate dehydrogenase [Mesorhizobium lo... 715 0.0
sp|P50217|IDHC_SOLTU Isocitrate dehydrogenase [NADP] (Oxalo... 714 0.0
ref|NP_001043749.1| Os01g0654500 [Oryza sativa (japonica cu... 714 0.0
gb|EEJ98364.1| isocitrate dehydrogenase (NADP) [Thermomonos... 714 0.0
gb|AAB39248.1| NADP-isocitrate dehydrogenase [Eucalyptus gl... 714 0.0
prf||2211361A isocitrate dehydrogenase 714 0.0
gb|AAC52473.1| isocitrate dehydrogenase 714 0.0
gb|AAV33246.1| isocitrate dehydrogenase [Toxoplasma gondii] 714 0.0
ref|NP_385898.1| isocitrate dehydrogenase [Sinorhizobium me... 714 0.0
ref|XP_970446.1| PREDICTED: similar to isocitrate dehydroge... 714 0.0
ref|XP_828183.1| isocitrate dehydrogenase [Trypanosoma bruc... 714 0.0
ref|YP_290624.1| isocitrate dehydrogenase [Thermobifida fus... 713 0.0
ref|YP_001327198.1| isocitrate dehydrogenase [Sinorhizobium... 713 0.0
gb|EDT29808.1| isocitrate dehydrogenase, NADP-dependent [Ol... 713 0.0
gb|AAF73472.1|AF268076_1 NADP-dependent isocitrate dehydrog... 713 0.0
emb|CAG02627.1| unnamed protein product [Tetraodon nigrovir... 713 0.0
ref|YP_001413846.1| isocitrate dehydrogenase, NADP-dependen... 713 0.0
gb|AAA33978.1| NADPH-specific isocitrate dehydrogenase 712 0.0
gb|ACO14957.1| Isocitrate dehydrogenase cytoplasmic [Caligu... 712 0.0
ref|NP_196963.2| isocitrate dehydrogenase, putative / NADP+... 712 0.0
pir||S33612 isocitrate dehydrogenase (NADP) (EC 1.1.1.42) -... 711 0.0
emb|CAA65503.1| isocitrate dehydrogenase (NADP+) [Nicotiana... 711 0.0
ref|XP_001778590.1| predicted protein [Physcomitrella paten... 711 0.0
ref|XP_968850.1| PREDICTED: similar to CG7176-PC, isoform C... 711 0.0
ref|ZP_02166681.1| isocitrate dehydrogenase [Hoeflea photot... 711 0.0
emb|CAA65504.1| isocitrate dehydrogenase (NADP+) [Nicotiana... 710 0.0
ref|YP_872148.1| isocitrate dehydrogenase [Acidothermus cel... 710 0.0
dbj|BAE48792.1| NADP-isocitrate dehydrogenase [Codonopsis l... 709 0.0
ref|NP_421325.1| isocitrate dehydrogenase [Caulobacter cres... 709 0.0
ref|YP_001296741.1| isocitrate dehydrogenase [Flavobacteriu... 709 0.0
gb|AAT06312.1| isocitrate dehydrogenase [Rhizobium legumino... 709 0.0
ref|ZP_02124492.1| Isocitrate dehydrogenase (NADP(+)) [Meth... 709 0.0
ref|ZP_02295934.1| isocitrate dehydrogenase, NADP-dependent... 709 0.0
ref|YP_768215.1| isocitrate dehydrogenase [Rhizobium legumi... 708 0.0
gb|AAD51361.1|AF176669_1 NADP-isocitrate dehydrogenase [Cit... 708 0.0
ref|YP_001609735.1| NADP-dependent isocitrate dehydrogenase... 708 0.0
dbj|BAA34113.1| NADP specific isocitrate dehydrogenase [Dau... 708 0.0
ref|ZP_02858718.1| isocitrate dehydrogenase, NADP-dependent... 708 0.0
ref|XP_001608101.1| PREDICTED: similar to isocitrate dehydr... 707 0.0
ref|ZP_00952302.1| isocitrate dehydrogenase [Oceanicaulis a... 707 0.0
ref|ZP_01228834.1| NADP dependent isocitrate dehydrogenase ... 707 0.0
gb|ABA18651.1| cytosolic NADP+-isocitrate dehydrogenase [Po... 707 0.0
ref|NP_354851.2| isocitrate dehydrogenase [Agrobacterium tu... 707 0.0
ref|XP_001176537.1| PREDICTED: similar to Isocitrate dehydr... 707 0.0
sp|Q06197|IDHC_SOYBN Isocitrate dehydrogenase [NADP] (Oxalo... 707 0.0
gb|AAL11503.1|AF367443_1 NADP-dependent isocitrate dehydrog... 707 0.0
ref|YP_706173.1| isocitrate dehydrogenase [Rhodococcus sp. ... 707 0.0
ref|YP_001685152.1| isocitrate dehydrogenase, NADP-dependen... 706 0.0
ref|YP_001538953.1| isocitrate dehydrogenase, NADP-dependen... 706 0.0
dbj|BAA34112.1| NADP specific isocitrate dehydrogenase [Dau... 706 0.0
ref|XP_312860.4| AGAP003168-PA [Anopheles gambiae str. PEST... 706 0.0
gb|ABK24873.1| unknown [Picea sitchensis] 706 0.0
ref|YP_001524781.1| NADP-dependent isocitrate dehydrogenase... 706 0.0
ref|NP_175836.1| ICDH; isocitrate dehydrogenase (NADP+) [Ar... 706 0.0
dbj|BAC77063.1| NADP-specific isocitrate dehydrogenase [Lup... 706 0.0
ref|ZP_03896321.1| isocitrate dehydrogenase (NADP) [Dyadoba... 705 0.0
ref|NP_001040134.1| isocitrate dehydrogenase [Bombyx mori] ... 705 0.0
ref|YP_001160602.1| isocitrate dehydrogenase [Salinispora t... 705 0.0
ref|YP_001769504.1| isocitrate dehydrogenase, NADP-dependen... 705 0.0
dbj|BAC77064.1| NADP-specific isocitrate dehydrogenase [Lup... 704 0.0
ref|XP_001240510.1| isocitrate dehydrogenase NADP, mitochon... 704 0.0
emb|CAA73139.1| isocitrate dehydrogenase (NADP+) [Apium gra... 704 0.0
emb|CAD24779.1| isocitrate dehydrogenase [Cucumis sativus] 704 0.0
ref|XP_623673.2| PREDICTED: similar to Isocitrate dehydroge... 703 0.0
ref|YP_002761841.1| NADP-dependent isocitrate dehydrogenase... 703 0.0
ref|XP_754749.1| isocitrate dehydrogenase Idp1 [Aspergillus... 703 0.0
gb|EDP52872.1| isocitrate dehydrogenase Idp1, putative [Asp... 703 0.0
gb|EAY99113.1| hypothetical protein OsI_020346 [Oryza sativ... 703 0.0
ref|YP_617009.1| isocitrate dehydrogenase [Sphingopyxis ala... 703 0.0
gb|ABI52605.1| isocitrate dehydrogenase [Gryllus firmus] 703 0.0
gb|AAR05796.1| NADP+-isocitrate dehydrogenase [Pinus pinaster] 703 0.0
gb|AAS49171.1| NADP-dependent isocitrate dehydrogenase [Pis... 703 0.0
ref|YP_001709366.1| isocitrate dehydrogenase [Clavibacter m... 703 0.0
ref|YP_001223282.1| isocitrate dehydrogenase [Clavibacter m... 703 0.0
emb|CAB87626.1| isocitrate dehydrogenase-like protein [Arab... 703 0.0
emb|CAA63220.1| isocitrate dehydrogenase (NAD+) [Solanum tu... 703 0.0
ref|ZP_03869030.1| isocitrate dehydrogenase (NADP) [Jonesia... 702 0.0
ref|YP_682929.1| isocitrate dehydrogenase [Roseobacter deni... 702 0.0
ref|ZP_01546031.1| isocitrate dehydrogenase [Stappia aggreg... 701 0.0
ref|YP_001419447.1| isocitrate dehydrogenase, NADP-dependen... 701 0.0
emb|CAN72808.1| hypothetical protein [Vitis vinifera] >gi|1... 701 0.0
ref|ZP_01303522.1| isocitrate dehydrogenase, NADP-dependent... 701 0.0
ref|YP_032403.1| isocitrate dehydrogenase [Bartonella quint... 701 0.0
ref|YP_117132.1| isocitrate dehydrogenase [Nocardia farcini... 701 0.0
ref|ZP_01440188.1| Isocitrate/isopropylmalate dehydrogenase... 701 0.0
ref|YP_002783489.1| isocitrate dehydrogenase [Rhodococcus o... 701 0.0
ref|ZP_01862723.1| isocitrate dehydrogenase [Erythrobacter ... 700 0.0
ref|ZP_00954676.1| isocitrate dehydrogenase [Sulfitobacter ... 700 0.0
ref|YP_496560.1| isocitrate dehydrogenase [Novosphingobium ... 700 0.0
ref|ZP_00964081.1| isocitrate dehydrogenase [Sulfitobacter ... 700 0.0
ref|YP_033790.1| isocitrate dehydrogenase [Bartonella hense... 700 0.0
ref|ZP_01040029.1| isocitrate dehydrogenase [Erythrobacter ... 700 0.0
ref|YP_002765452.1| NADP-dependent isocitrate dehydrogenase... 699 0.0
ref|YP_756242.1| isocitrate dehydrogenase [Maricaulis maris... 699 0.0
ref|YP_001832264.1| isocitrate dehydrogenase, NADP-dependen... 699 0.0
ref|XP_001020930.2| dehydrogenase, isocitrate/isopropylmala... 699 0.0
ref|YP_001758392.1| isocitrate dehydrogenase, NADP-dependen... 698 0.0
ref|XP_001384028.1| Isocitrate dehydrogenase [NADP], mitoch... 698 0.0
ref|NP_772387.1| isocitrate dehydrogenase [Bradyrhizobium j... 698 0.0
ref|YP_001233708.1| isocitrate dehydrogenase [Acidiphilium ... 698 0.0
ref|NP_001053269.1| Os04g0508200 [Oryza sativa (japonica cu... 698 0.0
ref|XP_955850.1| hypothetical protein NCU03857 [Neurospora ... 697 0.0
sp|P79089|IDHP_ASPNG Isocitrate dehydrogenase [NADP], mitoc... 696 0.0
gb|AAK76730.1| mitochondrial NADP-dependent isocitrate dehy... 696 0.0
ref|XP_001462393.1| hypothetical protein GSPATT00027349001 ... 696 0.0
ref|ZP_03819206.1| isocitrate dehydrogenase (NADP) [Actinos... 696 0.0
ref|XP_001845030.1| isocitrate dehydrogenase [Culex pipiens... 696 0.0
ref|ZP_02955422.1| isocitrate dehydrogenase, NADP-dependent... 696 0.0
ref|YP_989041.1| isocitrate dehydrogenase [Bartonella bacil... 696 0.0
ref|XP_001903959.1| unnamed protein product [Podospora anse... 696 0.0
ref|XP_001454244.1| hypothetical protein GSPATT00020509001 ... 696 0.0
ref|NP_949171.1| isocitrate dehydrogenase [Rhodopseudomonas... 695 0.0
emb|CAE04728.1| OSJNBa0043L24.16 [Oryza sativa (japonica cu... 695 0.0
emb|CAO64975.1| unnamed protein product [Vitis vinifera] 695 0.0
ref|XP_001670101.1| Hypothetical protein CBG21657 [Caenorha... 695 0.0
ref|YP_062774.1| isocitrate dehydrogenase [Leifsonia xyli s... 695 0.0
sp|P50215|IDH_SPHYA Isocitrate dehydrogenase [NADP] (Oxalos... 695 0.0
ref|XP_451683.1| unnamed protein product [Kluyveromyces lac... 695 0.0
ref|XP_001226620.1| conserved hypothetical protein [Chaetom... 695 0.0
ref|YP_458429.1| isocitrate dehydrogenase [Erythrobacter li... 695 0.0
gb|EAY58582.1| isocitrate dehydrogenase [NADP] icd1 [Mycoba... 695 0.0
ref|YP_001833636.1| isocitrate dehydrogenase, NADP-dependen... 695 0.0
ref|NP_217856.1| isocitrate dehydrogenase [Mycobacterium tu... 694 0.0
ref|NP_001093090.1| NADPH-specific isocitrate dehydrogenase... 694 0.0
ref|NP_176768.1| isocitrate dehydrogenase, putative / NADP+... 694 0.0
emb|CAH67563.1| OSIGBa0101P20.6 [Oryza sativa (indica culti... 694 0.0
ref|YP_001623415.1| isocitrate dehydrogenase (NADP) [Reniba... 694 0.0
ref|XP_001528456.1| isocitrate dehydrogenase, mitochondrial... 694 0.0
ref|YP_001204807.1| isocitrate dehydrogenase [Bradyrhizobiu... 694 0.0
ref|YP_979491.1| isocitrate dehydrogenase [Mycobacterium bo... 693 0.0
gb|AAM13090.1| similar to NADP-specific isocitrate dehydrog... 693 0.0
ref|YP_001849499.1| isocitrate dehydrogenase [NADP] Icd1 [M... 693 0.0
ref|YP_001363715.1| isocitrate dehydrogenase, NADP-dependen... 693 0.0
ref|XP_710919.1| NADP-specific isocitrate dehydrogenase [Ca... 693 0.0
gb|ABO93633.1| isocitrate dehydrogenase 2 [Toxoplasma gondii] 693 0.0
emb|CAD24782.1| isocitrate dehydrogenase [Arabidopsis thali... 693 0.0
ref|YP_759895.1| isocitrate dehydrogenase [Hyphomonas neptu... 693 0.0
ref|XP_001878769.1| predicted protein [Laccaria bicolor S23... 693 0.0
ref|ZP_02302766.1| isocitrate dehydrogenase, NADP-dependent... 693 0.0
gb|AAT44354.1| isocitrate dehydrogenase [Crassostrea gigas] 693 0.0
ref|XP_001676039.1| Hypothetical protein CBG17397 [Caenorha... 692 0.0
ref|YP_001169228.1| isocitrate dehydrogenase [Rhodobacter s... 692 0.0
gb|ABF20272.1| mitochondrial isocitrate dehydrogenase [Leis... 692 0.0
ref|YP_487337.1| isocitrate dehydrogenase [Rhodopseudomonas... 692 0.0
gb|AAM65674.1| isocitrate dehydrogenase, putative [Arabidop... 691 0.0
ref|YP_001241304.1| isocitrate dehydrogenase [Bradyrhizobiu... 691 0.0
ref|XP_001400371.1| precursor of mitochondrial isocitrate d... 691 0.0
ref|ZP_01018081.1| isocitrate dehydrogenase [Parvularcula b... 691 0.0
gb|ABF20244.1| mitochondrial isocitrate dehydrogenase [Leis... 691 0.0
ref|ZP_03813993.1| isocitrate dehydrogenase (NADP) [Beutenb... 691 0.0
ref|YP_001260963.1| isocitrate dehydrogenase [Sphingomonas ... 691 0.0
ref|XP_001463680.1| isocitrate dehydrogenase [NADP], mitoch... 691 0.0
ref|YP_001168561.1| isocitrate dehydrogenase [Rhodobacter s... 691 0.0
ref|XP_001457045.1| hypothetical protein GSPATT00022820001 ... 691 0.0
ref|ZP_03922528.1| isocitrate dehydrogenase [Mobiluncus cur... 691 0.0
ref|XP_001426548.1| hypothetical protein GSPATT00029781001 ... 690 0.0
ref|XP_001593497.1| hypothetical protein SS1G_04924 [Sclero... 690 0.0
ref|NP_501665.1| F59B8.2 [Caenorhabditis elegans] >gi|38778... 690 0.0
ref|YP_001043974.1| isocitrate dehydrogenase [Rhodobacter s... 690 0.0
ref|YP_568874.1| isocitrate dehydrogenase [Rhodopseudomonas... 690 0.0
ref|YP_001042101.1| isocitrate dehydrogenase [Rhodobacter s... 689 0.0
ref|NP_001042583.1| Os01g0248400 [Oryza sativa (japonica cu... 689 0.0
ref|XP_459772.1| hypothetical protein DEHA0E11286g [Debaryo... 689 0.0
ref|YP_001108727.1| isocitrate dehydrogenase [Saccharopolys... 689 0.0
ref|ZP_00960755.1| Isocitrate dehydrogenase [Roseovarius nu... 689 0.0
ref|XP_001681361.1| isocitrate dehydrogenase [NADP], mitoch... 689 0.0
ref|YP_353519.1| isocitrate dehydrogenase [Rhodobacter spha... 689 0.0
ref|XP_504978.1| hypothetical protein [Yarrowia lipolytica]... 688 0.0
ref|YP_351602.1| isocitrate dehydrogenase [Rhodobacter spha... 688 0.0
gb|ABL97438.1| isocitrate dehydrogenase [uncultured marine ... 688 0.0
gb|AAK76731.1| peroxisomal NADP-dependent isocitrate dehydr... 688 0.0
ref|XP_780121.1| PREDICTED: similar to cytosolic NADP-depen... 688 0.0
ref|XP_001484278.1| isocitrate dehydrogenase, mitochondrial... 688 0.0
ref|ZP_01046178.1| isocitrate dehydrogenase NADP-dependent ... 688 0.0
ref|ZP_01448513.1| isocitrate dehydrogenase [alpha proteoba... 687 0.0
ref|XP_001837820.1| hypothetical protein CC1G_11465 [Coprin... 687 0.0
ref|YP_001601185.1| Isocitrate dehydrogenase [Gluconacetoba... 687 0.0
ref|YP_531457.1| isocitrate dehydrogenase [Rhodopseudomonas... 687 0.0
ref|YP_909639.1| isocitrate dehydrogenase [Bifidobacterium ... 687 0.0
ref|ZP_01157336.1| isocitrate dehydrogenase [Oceanicola gra... 686 0.0
gb|ABF20271.1| mitochondrial isocitrate dehydrogenase [Leis... 686 0.0
ref|YP_576902.1| isocitrate dehydrogenase [Nitrobacter hamb... 686 0.0
ref|YP_317907.1| isocitrate dehydrogenase [Nitrobacter wino... 686 0.0
ref|XP_001263574.1| isocitrate dehydrogenase Idp1, putative... 686 0.0
ref|ZP_02963068.1| isocitrate dehydrogenase [Bifidobacteriu... 685 0.0
ref|ZP_02981592.1| isocitrate dehydrogenase, NADP-dependent... 685 0.0
ref|NP_509875.1| C34F6.8 [Caenorhabditis elegans] >gi|38747... 685 0.0
ref|XP_001562802.1| isocitrate dehydrogenase [NADP], mitoch... 685 0.0
ref|ZP_00206729.1| COG0538: Isocitrate dehydrogenases [Bifi... 685 0.0
ref|XP_390523.1| hypothetical protein FG10347.1 [Gibberella... 684 0.0
ref|ZP_01751534.1| isocitrate dehydrogenase [Roseobacter sp... 684 0.0
ref|YP_780531.1| isocitrate dehydrogenase [Rhodopseudomonas... 684 0.0
sp|O13285|IDH1_CANTR Isocitrate dehydrogenase [NADP], mitoc... 684 0.0
ref|NP_696658.1| isocitrate dehydrogenase [Bifidobacterium ... 684 0.0
ref|XP_847200.1| isocitrate dehydrogenase [NADP], mitochond... 684 0.0
ref|XP_001818331.1| hypothetical protein [Aspergillus oryza... 684 0.0
ref|ZP_01130474.1| isocitrate dehydrogenase [marine actinob... 683 0.0
ref|ZP_03993927.1| isocitrate dehydrogenase [Mobiluncus mul... 683 0.0
ref|ZP_03977360.1| isocitrate dehydrogenase (NADP(+)) [Bifi... 683 0.0
ref|XP_001614236.1| isocitrate dehydrogenase [NADP], mitoch... 683 0.0
ref|XP_001507484.1| PREDICTED: similar to isocitrate dehydr... 683 0.0
ref|NP_010217.1| Mitochondrial NADP-specific isocitrate deh... 682 0.0
ref|XP_367343.2| hypothetical protein MGG_07268 [Magnaporth... 682 0.0
ref|NP_962389.1| isocitrate dehydrogenase [Mycobacterium av... 682 0.0
ref|XP_645284.1| isocitrate dehydrogenase (NADP+) [Dictyost... 682 0.0
ref|XP_660603.1| IDHP_ASPNG ISOCITRATE DEHYDROGENASE [NADP]... 681 0.0
ref|XP_001270886.1| isocitrate dehydrogenase Idp1, putative... 681 0.0
gb|ABK25438.1| unknown [Picea sitchensis] 680 0.0
ref|ZP_02139240.1| isocitrate dehydrogenase [Roseobacter li... 680 0.0
ref|NP_729367.1| Isocitrate dehydrogenase CG7176-PD, isofor... 680 0.0
ref|YP_883449.1| isocitrate dehydrogenase [Mycobacterium av... 680 0.0
ref|NP_729366.1| Isocitrate dehydrogenase CG7176-PB, isofor... 679 0.0
Sequences not found previously or not previously below threshold:
>ref|XP_536192.2| PREDICTED: similar to isocitrate dehydrogenase 2 (NADP+),
mitochondrial [Canis familiaris]
Length = 517
Score = 738 bits (1906), Expect = 0.0, Method: Composition-based stats.
Identities = 256/409 (62%), Positives = 320/409 (78%), Gaps = 1/409 (0%)
Query: 3 KISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEAAY 62
+I +VE+DGDEMTR+IW+ IKE LI P V+V ++Y+DL + NRD+T D+VT+++A
Sbjct: 109 RIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDVQLKYFDLGLPNRDQTNDQVTIDSAL 168
Query: 63 AIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRLVT 122
A +K+ V VKCATITPDEARV+EF LKKMW+SPNGTIR ILGGTVFREPIIC N+PRLV
Sbjct: 169 ATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVP 228
Query: 123 TWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGGVMMGMY 182
W KP+ IGRHA GDQY ATD VV GTF++ F P +G K ++V+++ GGV MGMY
Sbjct: 229 GWTKPITIGRHAHGDQYKATDFVVDRAGTFKIIFSPKDGSGAKEWEVYNFPGGGVGMGMY 288
Query: 183 NTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKTCG 242
NTD+SI FA SCF++A+ +KWPLY+STKNTILK YDGRFKDIF E+++ Y+T F
Sbjct: 289 NTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFEKHYKTDFDKNK 348
Query: 243 IFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGKTV 302
I+YEHRLIDDMVA ++S GG+VWACKNYDGDVQSD LAQGFGSLG+MTS+L+ PDGKT+
Sbjct: 349 IWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTI 408
Query: 303 EVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLEDVI 362
E EAAHGTVTRHYR++QKG+ TSTNP+ASIFAWTR L HR ++D N L+ F Q LE V
Sbjct: 409 EAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQTLEKVC 468
Query: 363 IATIEAGAMTEDLAICIKGEKNVV-RADYLNTDEFIDAVSQRLKVAMQK 410
+ T+E+GAMT+DLA CI G NV +LNT +F+D + L A+ +
Sbjct: 469 VQTVESGAMTKDLAGCIHGLSNVKLNEHFLNTSDFLDTIKNNLDKALGQ 517
>ref|NP_786984.1| isocitrate dehydrogenase 2 (NADP+), mitochondrial [Bos taurus]
emb|CAA49207.1| isocitrate dehydrogenase (NADP+) [Bos taurus]
Length = 452
Score = 737 bits (1903), Expect = 0.0, Method: Composition-based stats.
Identities = 256/410 (62%), Positives = 322/410 (78%), Gaps = 1/410 (0%)
Query: 3 KISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEAAY 62
+I +VE+DGDEMTR+IW+ IKE LI P V+V ++Y+DL + NRD+T D+VT+++A
Sbjct: 43 RIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDVQLKYFDLGLPNRDQTNDQVTIDSAL 102
Query: 63 AIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRLVT 122
A +K+ V VKCATITPDEARV+EF LKKMW+SPNGTIR ILGGTVFREPIIC N+PRLV
Sbjct: 103 ATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVP 162
Query: 123 TWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGGVMMGMY 182
W KP+ IGRHA GDQY ATD VV GTF++ F P +G PK ++V+++ +GGV MGMY
Sbjct: 163 GWTKPITIGRHAHGDQYKATDFVVDRAGTFKVVFTPKDGSGPKEWEVYNFPAGGVGMGMY 222
Query: 183 NTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKTCG 242
NTD+SI FA SCF++A+ +KWPLY+STKNTILK YDGRFKDIF +++ Y+T+F
Sbjct: 223 NTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQAIFEKHYKTEFDKHK 282
Query: 243 IFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGKTV 302
I+YEHRLIDDMVA ++S GG+VWACKNYDGDVQSD LAQGFGSLG+MTS+L+ PDGKT+
Sbjct: 283 IWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTI 342
Query: 303 EVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLEDVI 362
E EAAHGTVTRHYR++QKG+ TSTNP+ASIFAWTR L HR ++D N L+ F Q LE V
Sbjct: 343 EAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQTLEKVC 402
Query: 363 IATIEAGAMTEDLAICIKGEKNVV-RADYLNTDEFIDAVSQRLKVAMQKS 411
+ T+E+GAMT+DLA CI G NV +LNT +F+D + L A+ +
Sbjct: 403 VETVESGAMTKDLAGCIHGLSNVKLNEHFLNTSDFLDTIKSNLDRALGQQ 452
>sp|Q04467|IDHP_BOVIN Isocitrate dehydrogenase [NADP], mitochondrial precursor
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) (IDP) (ICD-M)
gb|AAI02510.1| Isocitrate dehydrogenase 2 (NADP+), mitochondrial [Bos taurus]
Length = 452
Score = 736 bits (1902), Expect = 0.0, Method: Composition-based stats.
Identities = 256/410 (62%), Positives = 322/410 (78%), Gaps = 1/410 (0%)
Query: 3 KISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEAAY 62
+I +VE+DGDEMTR+IW+ IKE LI P V+V ++Y+DL + NRD+T D+VT+++A
Sbjct: 43 RIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDVQLKYFDLGLPNRDQTNDQVTIDSAL 102
Query: 63 AIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRLVT 122
A +K+ V VKCATITPDEARV+EF LKKMW+SPNGTIR ILGGTVFREPIIC N+PRLV
Sbjct: 103 ATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVP 162
Query: 123 TWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGGVMMGMY 182
W KP+ IGRHA GDQY ATD VV GTF++ F P +G PK ++V+++ +GGV MGMY
Sbjct: 163 GWTKPITIGRHAHGDQYKATDFVVDRAGTFKVVFTPKDGSGPKEWEVYNFPAGGVGMGMY 222
Query: 183 NTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKTCG 242
NTD+SI FA SCF++A+ +KWPLY+STKNTILK YDGRFKDIF +++ Y+T+F
Sbjct: 223 NTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQAIFEKHYKTEFDKHK 282
Query: 243 IFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGKTV 302
I+YEHRLIDDMVA ++S GG+VWACKNYDGDVQSD LAQGFGSLG+MTS+L+ PDGKT+
Sbjct: 283 IWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTI 342
Query: 303 EVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLEDVI 362
E EAAHGTVTRHYR++QKG+ TSTNP+ASIFAWTR L HR ++D N L+ F Q LE V
Sbjct: 343 EAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQTLEKVC 402
Query: 363 IATIEAGAMTEDLAICIKGEKNVV-RADYLNTDEFIDAVSQRLKVAMQKS 411
+ T+E+GAMT+DLA CI G NV +LNT +F+D + L A+ +
Sbjct: 403 VETVESGAMTKDLAGCIHGLSNVKLNEHFLNTSDFLDTIKSNLDRALGQQ 452
>ref|NP_851355.2| isocitrate dehydrogenase 1 (NADP+), soluble [Bos taurus]
gb|AAI03369.1| Isocitrate dehydrogenase 1 (NADP+), soluble [Bos taurus]
Length = 414
Score = 736 bits (1901), Expect = 0.0, Method: Composition-based stats.
Identities = 272/414 (65%), Positives = 333/414 (80%), Gaps = 1/414 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M++ G +VE+ GDEMTR+IW+ IKE LIFP+V + + YDL +ENRD T D+VT +A
Sbjct: 1 MSQKIQGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIKK+ VGVKCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 61 AEAIKKYNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDY-KSGGVMM 179
V+ W KP++IGRHA+GDQY ATD VV PG E+ + P++G VY V ++ +SGGV M
Sbjct: 121 VSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEISYTPSDGSPKTVYLVHNFTESGGVAM 180
Query: 180 GMYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFK 239
GMYN D SI DFA S F+ AL++ WPLYLSTKNTILK YDGRFKDIF E+Y Y+++F+
Sbjct: 181 GMYNQDKSIEDFAHSSFQMALSKNWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSEFE 240
Query: 240 TCGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDG 299
I+YEHRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDG
Sbjct: 241 AQNIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG 300
Query: 300 KTVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLE 359
KTVE EAAHGTVTRHYR YQKG+ETSTNP+ASIFAWTR LAHRA++DNN L F + LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELSFFAKALE 360
Query: 360 DVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
+V I TIEAG MT+DLA CIKG NV R+DYLNT EF+D + + L++ + ++K+
Sbjct: 361 EVCIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLQLKLAQAKL 414
>ref|NP_001026770.1| hypothetical protein LOC431056 [Gallus gallus]
emb|CAG31511.1| hypothetical protein [Gallus gallus]
Length = 452
Score = 736 bits (1901), Expect = 0.0, Method: Composition-based stats.
Identities = 258/409 (63%), Positives = 323/409 (78%), Gaps = 1/409 (0%)
Query: 3 KISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEAAY 62
+I +VE+DGDEMTR+IW IKE LI P V+V ++Y+DL + +RDKT+D+VT+++A
Sbjct: 43 RIKVANPVVEMDGDEMTRIIWAFIKEKLILPNVDVQLKYFDLGLPHRDKTDDQVTIDSAL 102
Query: 63 AIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRLVT 122
A KK+ V VKCATITPDEARV+EF LKKMW+SPNGTIR ILGGTVFREPIIC N+PRLV
Sbjct: 103 ATKKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVP 162
Query: 123 TWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGGVMMGMY 182
W +P+ IGRHA GDQY ATD VV + GTF+M F P +G K ++VF++ GGV MGMY
Sbjct: 163 GWTQPITIGRHAHGDQYKATDFVVNKSGTFKMVFTPKDGSGVKEWEVFNFPGGGVGMGMY 222
Query: 183 NTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKTCG 242
NTD+SI FA SCF++A+ +KWPLY+STKNTILK YDGRFKDIF E++ Y+T+F
Sbjct: 223 NTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTEFDKLK 282
Query: 243 IFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGKTV 302
I+YEHRLIDDMVA ++S GG+VWACKNYDGDVQSD LAQGFGSLG+MTS+L+ PDGKT+
Sbjct: 283 IWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTI 342
Query: 303 EVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLEDVI 362
E EAAHGTVTRHYR++QKG+ TSTNP+ASIFAWTR L HR ++D+N L++F Q LE V
Sbjct: 343 EAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDSNPELIKFAQTLEKVC 402
Query: 363 IATIEAGAMTEDLAICIKGEKNVV-RADYLNTDEFIDAVSQRLKVAMQK 410
+ T+E+G MT+DLA CI G NV ++NT +F+DA+ L A+ K
Sbjct: 403 VETVESGTMTKDLAGCIHGLANVKLNEHFVNTTDFLDAIKNTLDKALGK 451
>ref|XP_001369305.1| PREDICTED: hypothetical protein [Monodelphis domestica]
Length = 455
Score = 736 bits (1900), Expect = 0.0, Method: Composition-based stats.
Identities = 256/409 (62%), Positives = 323/409 (78%), Gaps = 1/409 (0%)
Query: 3 KISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEAAY 62
+I +VE+DGDEMTR+IW+ IKE LI P V+V ++Y+DL + +RD+T+D+VT+++A
Sbjct: 46 RIKVDKPVVEMDGDEMTRIIWQFIKEKLILPHVDVQLKYFDLGLPHRDQTDDQVTIDSAL 105
Query: 63 AIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRLVT 122
A +K+ V VKCATITPDEARV+EF LKKMW+SPNGTIR ILGGTVFREPIIC N+PRLV
Sbjct: 106 ATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVP 165
Query: 123 TWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGGVMMGMY 182
W +P+ IGRHA GDQY ATD VV + GTF+M F P +G K ++V+++ +GGV MGMY
Sbjct: 166 GWTRPITIGRHAHGDQYKATDFVVDKAGTFKMVFTPKDGSGAKEWEVYNFPAGGVGMGMY 225
Query: 183 NTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKTCG 242
NTD+SI FA SCF++A+ +KWPLY+STKNTILK YDGRFKDIF E++ Y+T F
Sbjct: 226 NTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNK 285
Query: 243 IFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGKTV 302
I+YEHRLIDDMVA ++S GG+VWACKNYDGDVQSD LAQGFGSLG+MTS+L+ PDGKT+
Sbjct: 286 IWYEHRLIDDMVAQVLKSNGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTI 345
Query: 303 EVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLEDVI 362
E EAAHGTVTRHYR++QKG+ TSTNP+ASIFAWTR L HR ++D N L++F Q LE V
Sbjct: 346 EAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIKFAQTLEKVC 405
Query: 363 IATIEAGAMTEDLAICIKGEKNVV-RADYLNTDEFIDAVSQRLKVAMQK 410
+ T+E+GAMT+DLA CI G NV YLNT +F+D + L A+ +
Sbjct: 406 VQTVESGAMTKDLAGCIHGLSNVKLNEHYLNTGDFLDTIKNNLDKALGQ 454
>ref|XP_001107627.1| PREDICTED: isocitrate dehydrogenase 1 (NADP+), soluble isoform 1
[Macaca mulatta]
ref|XP_001107810.1| PREDICTED: isocitrate dehydrogenase 1 (NADP+), soluble isoform 2
[Macaca mulatta]
ref|XP_001107875.1| PREDICTED: isocitrate dehydrogenase 1 (NADP+), soluble isoform 3
[Macaca mulatta]
ref|XP_001107934.1| PREDICTED: isocitrate dehydrogenase 1 (NADP+), soluble isoform 4
[Macaca mulatta]
ref|XP_001107992.1| PREDICTED: isocitrate dehydrogenase 1 (NADP+), soluble isoform 5
[Macaca mulatta]
Length = 414
Score = 736 bits (1900), Expect = 0.0, Method: Composition-based stats.
Identities = 273/414 (65%), Positives = 333/414 (80%), Gaps = 1/414 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M+K + G +VEL GDEMTR+IW+ IKE LIFP+V + ++ YDL +ENRD T D+VT +A
Sbjct: 1 MSKKISGGSVVELQGDEMTRIIWELIKEKLIFPYVELDLQSYDLGIENRDATNDQVTKDA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIKK+ VGVKCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 61 AEAIKKYNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYK-SGGVMM 179
V+ W KP++IGRHA+GDQY ATD VV PG E+ + P++G + Y V +++ GGV M
Sbjct: 121 VSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAM 180
Query: 180 GMYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFK 239
GMYN D SI DFA S F+ AL++ WPLYLSTKNTILK YDGRFKDIF E+Y Y+++F+
Sbjct: 181 GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE 240
Query: 240 TCGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDG 299
I+YEHRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDG
Sbjct: 241 AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG 300
Query: 300 KTVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLE 359
KTVE EAAHGTVTRHYR YQKG+ETSTNP+ASIFAWTR LAHRA++DNN L F LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALE 360
Query: 360 DVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
+V I TIEAG MT+DLA CIKG NV R+DYLNT EF+D + + LK+ + ++K+
Sbjct: 361 EVCIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL 414
>sp|P54071|IDHP_MOUSE Isocitrate dehydrogenase [NADP], mitochondrial precursor
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) (IDP) (ICD-M)
dbj|BAC40149.1| unnamed protein product [Mus musculus]
gb|AAH60030.1| Isocitrate dehydrogenase 2 (NADP+), mitochondrial [Mus musculus]
dbj|BAE41142.1| unnamed protein product [Mus musculus]
dbj|BAE36505.1| unnamed protein product [Mus musculus]
dbj|BAE26628.1| unnamed protein product [Mus musculus]
gb|EDL07035.1| isocitrate dehydrogenase 2 (NADP+), mitochondrial, isoform CRA_d
[Mus musculus]
Length = 452
Score = 735 bits (1898), Expect = 0.0, Method: Composition-based stats.
Identities = 257/410 (62%), Positives = 320/410 (78%), Gaps = 1/410 (0%)
Query: 3 KISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEAAY 62
+I +VE+DGDEMTR+IW+ IKE LI P V+V ++Y+DL + NRD+T D+VT+++A
Sbjct: 43 RIKVEKPVVEMDGDEMTRIIWQFIKEKLILPHVDVQLKYFDLGLPNRDQTNDQVTIDSAL 102
Query: 63 AIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRLVT 122
A +K+ V VKCATITPDEARV+EF LKKMW+SPNGTIR ILGGTVFREPIIC N+PRLV
Sbjct: 103 ATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVP 162
Query: 123 TWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGGVMMGMY 182
W KP+ IGRHA GDQY ATD VV GTF++ F P +G K ++V+++ +GGV MGMY
Sbjct: 163 GWTKPITIGRHAHGDQYKATDFVVDRAGTFKLVFTPKDGSSAKEWEVYNFPAGGVGMGMY 222
Query: 183 NTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKTCG 242
NTD+SI FA SCF++++ +KWPLYLSTKNTILK YDGRFKDIF E++ Y+T F
Sbjct: 223 NTDESISGFAHSCFQYSIQKKWPLYLSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNK 282
Query: 243 IFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGKTV 302
I+YEHRLIDDMVA ++S GG+VWACKNYDGDVQSD LAQGFGSLG+MTS+L+ PDGKT+
Sbjct: 283 IWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTI 342
Query: 303 EVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLEDVI 362
E EAAHGTVTRHYR++QKG+ TSTNP+ASIFAWTR L HR ++D N L+ F Q LE V
Sbjct: 343 EAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQTLEKVC 402
Query: 363 IATIEAGAMTEDLAICIKGEKNVV-RADYLNTDEFIDAVSQRLKVAMQKS 411
+ T+E+GAMT+DLA CI G NV +LNT +F+D + L A+ K
Sbjct: 403 VQTVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRALGKQ 452
>ref|NP_001009276.1| cytosolic NADP-isocitrate dehydrogenase [Ovis aries]
sp|Q6XUZ5|IDHC_SHEEP Isocitrate dehydrogenase [NADP] cytoplasmic (Cytosolic
NADP-isocitrate dehydrogenase) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP)
gb|AAP41947.1| cytosolic NADP-isocitrate dehydrogenase [Ovis aries]
Length = 414
Score = 735 bits (1898), Expect = 0.0, Method: Composition-based stats.
Identities = 272/414 (65%), Positives = 334/414 (80%), Gaps = 1/414 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M+ G +VE+ GDEMTR+IW+ IKE LIFP+V++ + YDLS+ENRD T D+VT +A
Sbjct: 1 MSHKIQGGSVVEMQGDEMTRIIWELIKEKLIFPYVDLDLHSYDLSIENRDATNDQVTKDA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIKK+ VGVKCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 61 AEAIKKYNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDY-KSGGVMM 179
V+ W KP++IGRHA+GDQY ATD VV PG E+ + P++G VY V ++ +SGGV M
Sbjct: 121 VSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEICYTPSDGSPKTVYLVHNFTESGGVAM 180
Query: 180 GMYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFK 239
GM+N D SI DFA S F+ AL++ WPLYLSTKNTILK YDGRFKDIF E+Y Y+++F+
Sbjct: 181 GMFNQDKSIEDFAHSSFQMALSKNWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE 240
Query: 240 TCGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDG 299
I+YEHRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDG
Sbjct: 241 AQNIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG 300
Query: 300 KTVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLE 359
KTVE EAAHGTVTRHYR YQKG+ETSTNP+ASIFAWTR LAHRA++DNN L F + LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELSFFAKALE 360
Query: 360 DVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
+V I TIEAG MT+DLA CIKG NV R+DYLNT EF+D + + L++ + ++K+
Sbjct: 361 EVCIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLQLKLAQAKL 414
>sp|Q9Z2K9|IDHC_MICME Isocitrate dehydrogenase [NADP] cytoplasmic (Cytosolic
NADP-isocitrate dehydrogenase) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP)
gb|AAD02924.1| cytosolic NADP-dependent isocitrate dehydrogenase [Microtus
mexicanus]
Length = 414
Score = 735 bits (1897), Expect = 0.0, Method: Composition-based stats.
Identities = 272/414 (65%), Positives = 328/414 (79%), Gaps = 1/414 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M+K G +VE+ GDEMTR+IW+ IKE LI P+V + + YDL +ENRD T D+VT +A
Sbjct: 1 MSKKIHGGSVVEMQGDEMTRIIWELIKEKLILPYVELDLHSYDLGIENRDATNDQVTKDA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIKK+ VGVKCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 61 AEAIKKYNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYK-SGGVMM 179
VT W KP++IGRHA+GDQY ATD VV PG E+ F P +G + Y V ++ GGV M
Sbjct: 121 VTGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITFTPKDGSQKVTYLVHSFEEGGGVAM 180
Query: 180 GMYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFK 239
GMYN D SI DFA S F+ AL++ WPLYLSTKNTILK YDGRFKDIF E+Y Y+++F+
Sbjct: 181 GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE 240
Query: 240 TCGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDG 299
I+YEHRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDG
Sbjct: 241 AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDG 300
Query: 300 KTVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLE 359
KTVE EAAHGTVTRHYR +QKG+ETSTNP+ASIFAW+R LAHRAR+DNN L F + LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMHQKGQETSTNPIASIFAWSRGLAHRARLDNNTELSFFAKALE 360
Query: 360 DVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
+V I TIEAG MT+DLA CIKG NV R+DYLNT EF+D + + LK + ++K+
Sbjct: 361 EVCIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKAKLAQAKL 414
>ref|NP_766599.1| isocitrate dehydrogenase 2 (NADP+), mitochondrial [Mus musculus]
gb|AAG43538.1|AF212319_1 NADP+-specific isocitrate dehydrogenase [Mus musculus]
Length = 452
Score = 734 bits (1895), Expect = 0.0, Method: Composition-based stats.
Identities = 257/410 (62%), Positives = 320/410 (78%), Gaps = 1/410 (0%)
Query: 3 KISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEAAY 62
+I +VE+DGDEMTR+IW+ IKE LI P V+V ++Y+DL + NRD+T D+VT+++A
Sbjct: 43 RIKVEKPVVEMDGDEMTRIIWQFIKEKLILPHVDVQLKYFDLGLPNRDQTNDQVTIDSAL 102
Query: 63 AIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRLVT 122
A +K+ V VKCATITPDEARV+EF LKKMW+SPNGTIR ILGGTVFREPIIC N+PRLV
Sbjct: 103 ATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVP 162
Query: 123 TWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGGVMMGMY 182
W KP+ IGRHA GDQY ATD VV GTF++ F P +G K ++V+++ +GGV MGMY
Sbjct: 163 GWTKPITIGRHAHGDQYKATDFVVDRAGTFKLVFTPKDGSSAKEWEVYNFPAGGVGMGMY 222
Query: 183 NTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKTCG 242
NTD+SI FA SCF++++ +KWPLYLSTKNTILK YDGRFKDIF E++ Y+T F
Sbjct: 223 NTDESISGFAHSCFQYSIQKKWPLYLSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDRNK 282
Query: 243 IFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGKTV 302
I+YEHRLIDDMVA ++S GG+VWACKNYDGDVQSD LAQGFGSLG+MTS+L+ PDGKT+
Sbjct: 283 IWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTI 342
Query: 303 EVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLEDVI 362
E EAAHGTVTRHYR++QKG+ TSTNP+ASIFAWTR L HR ++D N L+ F Q LE V
Sbjct: 343 EAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQTLEKVC 402
Query: 363 IATIEAGAMTEDLAICIKGEKNVV-RADYLNTDEFIDAVSQRLKVAMQKS 411
+ T+E+GAMT+DLA CI G NV +LNT +F+D + L A+ K
Sbjct: 403 VQTVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRALGKQ 452
>sp|Q9Z2K8|IDHC_MICOH Isocitrate dehydrogenase [NADP] cytoplasmic (Cytosolic
NADP-isocitrate dehydrogenase) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP)
gb|AAD02925.1| cytosolic NADP-dependent isocitrate dehydrogenase [Microtus
ochrogaster]
Length = 414
Score = 733 bits (1894), Expect = 0.0, Method: Composition-based stats.
Identities = 271/414 (65%), Positives = 328/414 (79%), Gaps = 1/414 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M+K G +VE+ GDEMTR+IW+ IKE LI P+V + + YDL +ENRD T D+VT +A
Sbjct: 1 MSKKIHGGSVVEMQGDEMTRIIWELIKEKLILPYVELDLHSYDLGIENRDATNDQVTKDA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIKK+ VGVKCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 61 AEAIKKYNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYK-SGGVMM 179
VT W KP++IGRHA+GDQY ATD VV PG E+ + P +G + Y V ++ GGV M
Sbjct: 121 VTGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPKDGSQKVTYLVHSFEEGGGVAM 180
Query: 180 GMYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFK 239
GMYN D SI DFA S F+ AL++ WPLYLSTKNTILK YDGRFKDIF E+Y Y+++F+
Sbjct: 181 GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE 240
Query: 240 TCGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDG 299
I+YEHRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDG
Sbjct: 241 AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDG 300
Query: 300 KTVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLE 359
KTVE EAAHGTVTRHYR +QKG+ETSTNP+ASIFAW+R LAHRAR+DNN L F + LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMHQKGQETSTNPIASIFAWSRGLAHRARLDNNTELSFFAKALE 360
Query: 360 DVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
+V I TIEAG MT+DLA CIKG NV R+DYLNT EF+D + + LK + ++K+
Sbjct: 361 EVCIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKAKLAQAKL 414
>ref|NP_113698.1| isocitrate dehydrogenase 1 (NADP+), soluble [Rattus norvegicus]
sp|P41562|IDHC_RAT Isocitrate dehydrogenase [NADP] cytoplasmic (Cytosolic
NADP-isocitrate dehydrogenase) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP)
gb|AAA59356.1| cytosolic NADP-dependent isocitrate dehydrogenase
gb|EDL98861.1| isocitrate dehydrogenase 1 (NADP+), soluble, isoform CRA_a [Rattus
norvegicus]
gb|EDL98863.1| isocitrate dehydrogenase 1 (NADP+), soluble, isoform CRA_a [Rattus
norvegicus]
gb|EDL98864.1| isocitrate dehydrogenase 1 (NADP+), soluble, isoform CRA_a [Rattus
norvegicus]
gb|EDL98865.1| isocitrate dehydrogenase 1 (NADP+), soluble, isoform CRA_a [Rattus
norvegicus]
Length = 414
Score = 733 bits (1894), Expect = 0.0, Method: Composition-based stats.
Identities = 272/414 (65%), Positives = 328/414 (79%), Gaps = 1/414 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M++ G +VE+ GDEMTR+IW+ IKE LI P+V + + YDL +ENRD T D+VT +A
Sbjct: 1 MSRKIHGGSVVEMQGDEMTRIIWELIKEKLILPYVELDLHSYDLGIENRDATNDQVTKDA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIKK+ VGVKCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 61 AEAIKKYNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYK-SGGVMM 179
VT W KP++IGRHA+GDQY ATD VV PG E+ + P +G + Y V D++ GGV M
Sbjct: 121 VTGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPKDGSQKVTYLVHDFEEGGGVAM 180
Query: 180 GMYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFK 239
GMYN D SI DFA S F+ AL++ WPLYLSTKNTILK YDGRFKDIF E+Y Y++KF+
Sbjct: 181 GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSKFE 240
Query: 240 TCGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDG 299
I+YEHRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDG
Sbjct: 241 AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDG 300
Query: 300 KTVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLE 359
KTVE EAAHGTVTRHYR YQKG+ETSTNP+ASIFAW+R LAHRA++DNN L F LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWSRGLAHRAKLDNNTELSFFANALE 360
Query: 360 DVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
+V I TIEAG MT+DLA CIKG NV R+DYLNT EF+D + + LK + ++K+
Sbjct: 361 EVCIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKAKLAQAKL 414
>sp|Q9XSG3|IDHC_BOVIN Isocitrate dehydrogenase [NADP] cytoplasmic (Cytosolic
NADP-isocitrate dehydrogenase) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP)
gb|AAD34457.1|AF136009_1 cytosolic NADP+-dependent isocitrate dehydrogenase [Bos taurus]
Length = 414
Score = 733 bits (1894), Expect = 0.0, Method: Composition-based stats.
Identities = 271/414 (65%), Positives = 332/414 (80%), Gaps = 1/414 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M++ G +VE+ GDEMTR+IW+ IKE LIFP+V + + YDL +ENRD T D+VT +A
Sbjct: 1 MSQKIQGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIKK+ VGVKCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 61 AEAIKKYNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDY-KSGGVMM 179
V+ W KP++IGRHA+GDQY ATD VV PG E+ + P++G VY V ++ +SGGV M
Sbjct: 121 VSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEISYTPSDGSPKTVYLVHNFTESGGVAM 180
Query: 180 GMYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFK 239
GMYN D SI DFA S F+ AL++ WPLYLSTKNTILK YDGRFKDIF E+Y Y+++F+
Sbjct: 181 GMYNQDKSIEDFAHSSFQMALSKNWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSEFE 240
Query: 240 TCGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDG 299
I+YEHRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDG
Sbjct: 241 AQNIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG 300
Query: 300 KTVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLE 359
KTVE EAAHGTVTRHYR YQKG+ET TNP+ASIFAWTR LAHRA++DNN L F + LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMYQKGQETLTNPIASIFAWTRGLAHRAKLDNNKELSFFAKALE 360
Query: 360 DVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
+V I TIEAG MT+DLA CIKG NV R+DYLNT EF+D + + L++ + ++K+
Sbjct: 361 EVCIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLQLKLAQAKL 414
>ref|XP_850187.1| PREDICTED: similar to Isocitrate dehydrogenase [NADP] cytoplasmic
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) (IDP) isoform 2 [Canis familiaris]
ref|XP_536047.2| PREDICTED: similar to Isocitrate dehydrogenase [NADP] cytoplasmic
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) (IDP) isoform 1 [Canis familiaris]
Length = 414
Score = 733 bits (1894), Expect = 0.0, Method: Composition-based stats.
Identities = 270/414 (65%), Positives = 331/414 (79%), Gaps = 1/414 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M++ G +VE+ GDEMTR+IW+ IKE LIFP+V + + YDL +ENRD T D+VT +A
Sbjct: 1 MSQKIRGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIKK+ VGVKCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 61 AEAIKKYNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYK-SGGVMM 179
V+ W KP++IGRHA+GDQY ATD VV PG E+ + P++G E Y V +++ GGV M
Sbjct: 121 VSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGSEKMTYLVHNFEEGGGVAM 180
Query: 180 GMYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFK 239
GMYN D SI DFA S F+ AL++ WPLYLSTKNTILK YDGRFKDIF E+Y Y+++F+
Sbjct: 181 GMYNQDKSIEDFAHSSFQMALSKSWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE 240
Query: 240 TCGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDG 299
I+YEHRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDG
Sbjct: 241 AQNIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG 300
Query: 300 KTVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLE 359
KTVE EAAHGTVTRHYR YQKG+ETSTNP+ASIFAWTR LAHRA++DNN L F + LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELSFFAKALE 360
Query: 360 DVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
+V + TIEAG MT+DLA CIKG NV R+DYLNT EF+D + + L + + ++K+
Sbjct: 361 EVCVETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLNIKLAQAKL 414
>emb|CAG38738.1| IDH1 [Homo sapiens]
Length = 414
Score = 733 bits (1894), Expect = 0.0, Method: Composition-based stats.
Identities = 274/414 (66%), Positives = 332/414 (80%), Gaps = 1/414 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M+K + G +VE+ GDEMTR+IW+ IKE LIFP+V + + YDL +ENRD T D+VT +A
Sbjct: 1 MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIKKH VGVKCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 61 AEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYK-SGGVMM 179
V+ W KP++IGRHA+GDQY ATD VV PG EM + P++G + Y V +++ GGV M
Sbjct: 121 VSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEMTYTPSDGTQKVTYLVHNFEEGGGVAM 180
Query: 180 GMYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFK 239
GMYN D SI DFA S F+ AL++ WPLYLSTKNTILK YDGRFKDIF E+Y Y+++F+
Sbjct: 181 GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE 240
Query: 240 TCGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDG 299
I+YEHRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDG
Sbjct: 241 AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG 300
Query: 300 KTVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLE 359
KTVE EAAHGTVTRHYR YQKG+ETSTNP+ASIFAWTR LAHRA++DNN L F LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALE 360
Query: 360 DVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
+V I TIEAG MT+DLA CIKG NV R+DYLNT EF+D + + LK+ + ++K+
Sbjct: 361 EVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL 414
>ref|NP_005887.2| isocitrate dehydrogenase 1 (NADP+), soluble [Homo sapiens]
sp|O75874|IDHC_HUMAN Isocitrate dehydrogenase [NADP] cytoplasmic (Cytosolic
NADP-isocitrate dehydrogenase) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP)
pdb|1T09|A Chain A, Crystal Structure Of Human Cytosolic Nadp(+)-Dependent
Isocitrate Dehydrogenase In Complex Nadp
pdb|1T09|B Chain B, Crystal Structure Of Human Cytosolic Nadp(+)-Dependent
Isocitrate Dehydrogenase In Complex Nadp
pdb|1T0L|A Chain A, Crystal Structure Of Human Cytosolic Nadp(+)-Dependent
Isocitrate Dehydrogenase In Complex With Nadp,
Isocitrate, And Calcium(2+)
pdb|1T0L|B Chain B, Crystal Structure Of Human Cytosolic Nadp(+)-Dependent
Isocitrate Dehydrogenase In Complex With Nadp,
Isocitrate, And Calcium(2+)
pdb|1T0L|C Chain C, Crystal Structure Of Human Cytosolic Nadp(+)-Dependent
Isocitrate Dehydrogenase In Complex With Nadp,
Isocitrate, And Calcium(2+)
pdb|1T0L|D Chain D, Crystal Structure Of Human Cytosolic Nadp(+)-Dependent
Isocitrate Dehydrogenase In Complex With Nadp,
Isocitrate, And Calcium(2+)
gb|AAD29284.1|AF113917_1 NADP+-dependent isocitrate dehydrogenase [Homo sapiens]
gb|AAH12846.1| IDH1 protein [Homo sapiens]
emb|CAG46496.1| IDH1 [Homo sapiens]
gb|AAX93221.1| unknown [Homo sapiens]
gb|EAW70439.1| isocitrate dehydrogenase 1 (NADP+), soluble, isoform CRA_a [Homo
sapiens]
gb|EAW70441.1| isocitrate dehydrogenase 1 (NADP+), soluble, isoform CRA_a [Homo
sapiens]
gb|EAW70442.1| isocitrate dehydrogenase 1 (NADP+), soluble, isoform CRA_a [Homo
sapiens]
gb|ABM82361.1| isocitrate dehydrogenase 1 (NADP+), soluble [synthetic construct]
gb|ABW03396.1| isocitrate dehydrogenase 1 (NADP+), soluble [synthetic construct]
Length = 414
Score = 733 bits (1892), Expect = 0.0, Method: Composition-based stats.
Identities = 273/414 (65%), Positives = 332/414 (80%), Gaps = 1/414 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M+K + G +VE+ GDEMTR+IW+ IKE LIFP+V + + YDL +ENRD T D+VT +A
Sbjct: 1 MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIKKH VGVKCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 61 AEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYK-SGGVMM 179
V+ W KP++IGRHA+GDQY ATD VV PG E+ + P++G + Y V +++ GGV M
Sbjct: 121 VSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAM 180
Query: 180 GMYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFK 239
GMYN D SI DFA S F+ AL++ WPLYLSTKNTILK YDGRFKDIF E+Y Y+++F+
Sbjct: 181 GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE 240
Query: 240 TCGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDG 299
I+YEHRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDG
Sbjct: 241 AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG 300
Query: 300 KTVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLE 359
KTVE EAAHGTVTRHYR YQKG+ETSTNP+ASIFAWTR LAHRA++DNN L F LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALE 360
Query: 360 DVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
+V I TIEAG MT+DLA CIKG NV R+DYLNT EF+D + + LK+ + ++K+
Sbjct: 361 EVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL 414
>sp|Q5R9C5|IDHC_PONPY Isocitrate dehydrogenase [NADP] cytoplasmic (Cytosolic
NADP-isocitrate dehydrogenase) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP)
Length = 414
Score = 733 bits (1892), Expect = 0.0, Method: Composition-based stats.
Identities = 271/414 (65%), Positives = 332/414 (80%), Gaps = 1/414 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M+K + G +VE+ GDEMTR+IW+ IKE LIFP+V + + YDL +ENRD T D+VT +A
Sbjct: 1 MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIKK+ VGVKCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 61 AEAIKKYNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYK-SGGVMM 179
V+ W KP++IGRHA+GDQY ATD VV PG E+ + P++G + Y V +++ GGV M
Sbjct: 121 VSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAM 180
Query: 180 GMYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFK 239
GMYN D SI DFA S F+ AL++ WPLYLSTKNTILK YDGRFKDIF E+Y Y+++F+
Sbjct: 181 GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE 240
Query: 240 TCGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDG 299
I+YEHRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDG
Sbjct: 241 ARKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG 300
Query: 300 KTVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLE 359
KTVE EAAHGTVTRHYR YQKG+ETSTNP+ASIFAWTR LAHRA++DNN L F LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALE 360
Query: 360 DVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
+V + TIEAG MT+DLA CIKG NV R+DYLNT EF+D + + LK+ + ++K+
Sbjct: 361 EVSVETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL 414
>ref|XP_421965.2| PREDICTED: similar to cytosolic NADP-dependent isocitrate
dehydrogenase [Gallus gallus]
Length = 415
Score = 733 bits (1892), Expect = 0.0, Method: Composition-based stats.
Identities = 274/411 (66%), Positives = 332/411 (80%), Gaps = 1/411 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M+K G +VE+ GDEMTRVIW+ IKE LIFP+V++ + YDL +E+RD T D+VTVEA
Sbjct: 1 MSKKIHGGSVVEMQGDEMTRVIWELIKEKLIFPYVDLDLHSYDLGIEHRDATNDKVTVEA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIKK+ VG+KCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 61 AEAIKKYHVGIKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKS-GGVMM 179
V+ W KP+VIGRHA+GDQY ATD VV PG EM + P +GG+P Y V +++S GGV M
Sbjct: 121 VSGWVKPIVIGRHAYGDQYRATDFVVPGPGKVEMTYTPGDGGKPVTYLVHNFESCGGVAM 180
Query: 180 GMYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFK 239
GMYN D SI+DFA S F+ AL++ WPLY+STKNTILK YDGRFKDIF E+Y Y+++F+
Sbjct: 181 GMYNLDQSIKDFAHSSFQMALSKGWPLYMSTKNTILKRYDGRFKDIFQEIYDREYKSQFE 240
Query: 240 TCGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDG 299
I+YEHRLIDDMVA ++SEGG+VWACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDG
Sbjct: 241 AKKIWYEHRLIDDMVAQALKSEGGFVWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDG 300
Query: 300 KTVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLE 359
KTVE EAAHGTVTRHYR +QKG+ETSTNP+ASIFAWTR LAHRA++DNN +L F LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMHQKGQETSTNPIASIFAWTRGLAHRAKLDNNTSLKTFATALE 360
Query: 360 DVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQK 410
+V I TIE+G MT+DLA CIKG NV R+DYLNT EF+D ++ LK +
Sbjct: 361 EVCIETIESGFMTKDLAACIKGLPNVTRSDYLNTFEFMDKLAANLKGKLAS 411
>ref|NP_970434.1| isocitrate dehydrogenase [Bdellovibrio bacteriovorus HD100]
emb|CAE81088.1| isocitrate dehydrogenase (NADP) [Bdellovibrio bacteriovorus HD100]
Length = 409
Score = 732 bits (1891), Expect = 0.0, Method: Composition-based stats.
Identities = 266/408 (65%), Positives = 321/408 (78%), Gaps = 1/408 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M KI +VELDGDEMTR+IWK IK+ LI P++++ I+YYDL ME+RD T D+VTV+A
Sbjct: 1 MKKIKVANPVVELDGDEMTRIIWKFIKQQLILPYLDIDIKYYDLGMEHRDATNDQVTVDA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIKK+ VG+KCATITPDEARVKEFNLK+MW+SPNGTIR IL GTVFREPIIC NVPRL
Sbjct: 61 AEAIKKYNVGIKCATITPDEARVKEFNLKQMWKSPNGTIRNILDGTVFREPIICKNVPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGGVMMG 180
V W P+ IGRHAFGDQY ATD V K G + F P NGGE ++V+++K GV +
Sbjct: 121 VPNWTAPICIGRHAFGDQYRATDFVTKGKGKLTVTFQPENGGETITHEVYNFKGDGVALT 180
Query: 181 MYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKT 240
MYNTD+SI FARSCF AL +KWPLYLSTKNTILK YDGRFKDIF E+Y+ ++ KF
Sbjct: 181 MYNTDESITGFARSCFNQALTKKWPLYLSTKNTILKKYDGRFKDIFEEIYQKEFKAKFDA 240
Query: 241 CGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGK 300
GI YEHRLIDDMVA ++ G +VWACKNYDGDVQSD++AQGFGSLG+MTS+L+TPDGK
Sbjct: 241 AGITYEHRLIDDMVASALKWNGNFVWACKNYDGDVQSDTVAQGFGSLGLMTSVLVTPDGK 300
Query: 301 TVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLED 360
T+E EAAHGTVTRHYR +Q+GK TSTNP+ASIFAWTR L HR +DNN L++F Q LE
Sbjct: 301 TMESEAAHGTVTRHYRQHQQGKPTSTNPIASIFAWTRGLEHRGNLDNNQELVKFAQTLEK 360
Query: 361 VIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAM 408
V + T+EAG MT+DLA+CI G+K V Y+NT+ F+ + + LK A+
Sbjct: 361 VCVETVEAGFMTKDLAVCIYGDK-VPADKYMNTEPFLAKLDENLKKAL 407
>gb|ABU41004.1| isocitrate dehydrogenase 1 [Anser anser]
Length = 415
Score = 732 bits (1891), Expect = 0.0, Method: Composition-based stats.
Identities = 273/411 (66%), Positives = 333/411 (81%), Gaps = 1/411 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M+K G +VE+ GDEMTRVIW+ IKE LIFP+V++ + YDL +E+RD T D+VTVEA
Sbjct: 1 MSKKIHGGSVVEMQGDEMTRVIWELIKEKLIFPYVDLDLHSYDLGIEHRDATNDKVTVEA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIKK+ VG+KCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 61 AEAIKKYHVGIKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKS-GGVMM 179
V+ W KP+VIGRHA+GDQY ATD VV PG EM + P +GG+P Y V +++S GGV M
Sbjct: 121 VSGWVKPIVIGRHAYGDQYRATDFVVPGPGKVEMTYTPGDGGKPVTYLVHNFESCGGVAM 180
Query: 180 GMYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFK 239
GM+N D SI+DFA S F+ AL++ WPLY+STKNTILK YDGRFKDIF E+Y Y+++F+
Sbjct: 181 GMFNLDQSIKDFAHSSFQMALSKGWPLYMSTKNTILKRYDGRFKDIFQEIYDREYKSQFE 240
Query: 240 TCGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDG 299
I+YEHRLIDDMVA ++SEGG+VWACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDG
Sbjct: 241 AKKIWYEHRLIDDMVAQALKSEGGFVWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDG 300
Query: 300 KTVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLE 359
KTVE EAAHGTVTRHYR +QKG+ETSTNP+ASIFAWTR LAHRA++DNN +L F LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMHQKGQETSTNPIASIFAWTRGLAHRAKLDNNTSLKTFAAALE 360
Query: 360 DVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQK 410
+V I TIE+G MT+DLA CIKG NV R+DYLNT EF+D +++ LK +
Sbjct: 361 EVCIETIESGFMTKDLAACIKGLPNVTRSDYLNTFEFMDKLAENLKGKLAS 411
>gb|ABE98244.1| mitochondrial isocitrate dehydrogenase 2-like [Oreochromis
mossambicus]
Length = 452
Score = 732 bits (1890), Expect = 0.0, Method: Composition-based stats.
Identities = 256/409 (62%), Positives = 323/409 (78%), Gaps = 1/409 (0%)
Query: 3 KISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEAAY 62
+I +VE+DGDEMTR+IW+ IKE LI V+V ++Y+DL + RD+T+D+VT+++A
Sbjct: 44 RIKVANPVVEMDGDEMTRIIWEFIKEKLILTNVDVELKYFDLGLPYRDQTDDQVTIDSAL 103
Query: 63 AIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRLVT 122
A KK+ V VKCATITPDEARV+EF LKKMW+SPNGTIR ILGGTVFREPIIC N+PRLV
Sbjct: 104 ATKKYSVAVKCATITPDEARVEEFGLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVP 163
Query: 123 TWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGGVMMGMY 182
W +P+ IGRHAFGDQY ATD VV +PG F++ F PA+G K ++VFD+ +GG MGMY
Sbjct: 164 GWTQPITIGRHAFGDQYRATDFVVDQPGKFKIVFSPADGSTSKEWEVFDFPAGGCGMGMY 223
Query: 183 NTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKTCG 242
NTD+SI FA SCF++A+ +KWPLY+STKNTILK YDGRFKDIF ++++ Y+ +F
Sbjct: 224 NTDESITGFAHSCFQYAIGKKWPLYMSTKNTILKAYDGRFKDIFQDIFEKNYKPEFDKLK 283
Query: 243 IFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGKTV 302
I+YEHRLIDDMVA ++S G +VWACKNYDGDVQSD LAQGFGSLG+MTS+L+ PDGKT+
Sbjct: 284 IWYEHRLIDDMVAQVLKSSGAFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTI 343
Query: 303 EVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLEDVI 362
E EAAHGTVTRHYR++QKG+ TSTNP+ASIFAWTR L HR ++D N L++F Q LE V
Sbjct: 344 EAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNPDLIKFAQTLEQVC 403
Query: 363 IATIEAGAMTEDLAICIKGEKNVV-RADYLNTDEFIDAVSQRLKVAMQK 410
+AT+E+G MT+DLA CI G NV Y+NT +F+DA+ L A+ K
Sbjct: 404 VATVESGTMTKDLAGCIHGLSNVKLNEHYVNTTDFLDAIKTNLDKALGK 452
>ref|XP_001141655.1| PREDICTED: isocitrate dehydrogenase 1 (NADP+), soluble isoform 1
[Pan troglodytes]
ref|XP_001141734.1| PREDICTED: isocitrate dehydrogenase 1 (NADP+), soluble isoform 2
[Pan troglodytes]
ref|XP_001141810.1| PREDICTED: isocitrate dehydrogenase 1 (NADP+), soluble isoform 3
[Pan troglodytes]
ref|XP_001141879.1| PREDICTED: isocitrate dehydrogenase 1 (NADP+), soluble isoform 4
[Pan troglodytes]
ref|XP_001141947.1| PREDICTED: isocitrate dehydrogenase 1 (NADP+), soluble isoform 5
[Pan troglodytes]
ref|XP_001142041.1| PREDICTED: isocitrate dehydrogenase 1 (NADP+), soluble isoform 6
[Pan troglodytes]
ref|XP_001142113.1| PREDICTED: isocitrate dehydrogenase 1 (NADP+), soluble isoform 7
[Pan troglodytes]
ref|XP_001142197.1| PREDICTED: isocitrate dehydrogenase 1 (NADP+), soluble isoform 8
[Pan troglodytes]
Length = 414
Score = 732 bits (1890), Expect = 0.0, Method: Composition-based stats.
Identities = 272/414 (65%), Positives = 332/414 (80%), Gaps = 1/414 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M+K + G +VE+ GDEMTR+IW+ IKE LIFP+V + + YDL +ENRD T D+VT +A
Sbjct: 1 MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIKK+ VGVKCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 61 AEAIKKYNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYK-SGGVMM 179
V+ W KP++IGRHA+GDQY ATD VV PG E+ + P++G + Y V +++ GGV M
Sbjct: 121 VSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAM 180
Query: 180 GMYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFK 239
GMYN D SI DFA S F+ AL++ WPLYLSTKNTILK YDGRFKDIF E+Y Y+++F+
Sbjct: 181 GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKRYKSQFE 240
Query: 240 TCGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDG 299
I+YEHRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDG
Sbjct: 241 AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG 300
Query: 300 KTVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLE 359
KTVE EAAHGTVTRHYR YQKG+ETSTNP+ASIFAWTR LAHRA++DNN L F LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALE 360
Query: 360 DVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
+V I TIEAG MT+DLA CIKG NV R+DYLNT EF+D + + LK+ + ++K+
Sbjct: 361 EVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL 414
>ref|XP_510589.2| PREDICTED: isocitrate dehydrogenase 2 (NADP+), mitochondrial
isoform 4 [Pan troglodytes]
Length = 452
Score = 731 bits (1888), Expect = 0.0, Method: Composition-based stats.
Identities = 255/410 (62%), Positives = 320/410 (78%), Gaps = 1/410 (0%)
Query: 3 KISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEAAY 62
+I +VE+DGDEMTR+IW+ IKE LI P V++ ++Y+DL + NRD+T+D+VT+++A
Sbjct: 43 RIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSAL 102
Query: 63 AIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRLVT 122
A +K+ V VKCATITPDEARV+EF LKKMW+SPNGTIR ILGGTVFREPIIC N+PRLV
Sbjct: 103 ATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVP 162
Query: 123 TWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGGVMMGMY 182
W KP+ IGRHA GDQY ATD V GTF+M F P +G K ++V+++ +GGV MGMY
Sbjct: 163 GWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMY 222
Query: 183 NTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKTCG 242
NTD+SI FA SCF++A+ +KWPLY+STKNTILK YDGRFKDIF E++ Y+T F
Sbjct: 223 NTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNK 282
Query: 243 IFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGKTV 302
I+YEHRLIDDMVA ++S GG+VWACKNYDGDVQSD LAQGFGSLG+MTS+L+ PDGKT+
Sbjct: 283 IWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTI 342
Query: 303 EVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLEDVI 362
E EAAHGTVTRHYR++QKG+ TSTNP+ASIFAWTR L HR ++D N L+ F Q LE V
Sbjct: 343 EAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQTLEKVC 402
Query: 363 IATIEAGAMTEDLAICIKGEKNVV-RADYLNTDEFIDAVSQRLKVAMQKS 411
+ T+E+GAMT+DLA CI G NV +LNT +F+D + L A+ +
Sbjct: 403 VETVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRALGRQ 452
>ref|XP_860821.1| PREDICTED: similar to Isocitrate dehydrogenase [NADP] cytoplasmic
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) (IDP) isoform 4 [Canis familiaris]
Length = 415
Score = 731 bits (1888), Expect = 0.0, Method: Composition-based stats.
Identities = 271/415 (65%), Positives = 331/415 (79%), Gaps = 2/415 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M++ G +VE+ GDEMTR+IW+ IKE LIFP+V + + YDL +ENRD T D+VT +A
Sbjct: 1 MSQKIRGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIKK+ VGVKCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 61 AEAIKKYNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVY--KVFDYKSGGVM 178
V+ W KP++IGRHA+GDQY ATD VV PG E+ + P++G E Y +V +K GGV
Sbjct: 121 VSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGSEKMTYLIQVLSFKGGGVA 180
Query: 179 MGMYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKF 238
MGMYN D SI DFA S F+ AL++ WPLYLSTKNTILK YDGRFKDIF E+Y Y+++F
Sbjct: 181 MGMYNQDKSIEDFAHSSFQMALSKSWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQF 240
Query: 239 KTCGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPD 298
+ I+YEHRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PD
Sbjct: 241 EAQNIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPD 300
Query: 299 GKTVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRL 358
GKTVE EAAHGTVTRHYR YQKG+ETSTNP+ASIFAWTR LAHRA++DNN L F + L
Sbjct: 301 GKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELSFFAKAL 360
Query: 359 EDVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
E+V + TIEAG MT+DLA CIKG NV R+DYLNT EF+D + + L + + ++K+
Sbjct: 361 EEVCVETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLNIKLAQAKL 415
>ref|NP_001014183.1| isocitrate dehydrogenase 2 (NADP+), mitochondrial [Rattus
norvegicus]
sp|P56574|IDHP_RAT Isocitrate dehydrogenase [NADP], mitochondrial precursor
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) (IDP) (ICD-M)
gb|AAH76398.1| Similar to NADP+-specific isocitrate dehydrogenase [Rattus
norvegicus]
gb|EDM08608.1| similar to NADP+-specific isocitrate dehydrogenase, isoform CRA_b
[Rattus norvegicus]
Length = 452
Score = 731 bits (1888), Expect = 0.0, Method: Composition-based stats.
Identities = 255/410 (62%), Positives = 319/410 (77%), Gaps = 1/410 (0%)
Query: 3 KISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEAAY 62
+I +VE+DGDEMTR+IW+ IKE LI P V+V ++Y+DL + NRD+T D+VT+++A
Sbjct: 43 RIKVEKPVVEMDGDEMTRIIWQFIKEKLILPHVDVQLKYFDLGLPNRDQTNDQVTIDSAL 102
Query: 63 AIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRLVT 122
A +K+ V VKCATITPDEARV+EF LKKMW+SPNGTIR ILGGTVFREPIIC N+PRLV
Sbjct: 103 ATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVP 162
Query: 123 TWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGGVMMGMY 182
W KP+ IGRHA GDQY ATD VV G F++ F P +G K ++V+++ +GGV MGMY
Sbjct: 163 GWTKPITIGRHAHGDQYKATDFVVDRAGMFKLVFTPKDGSGAKEWEVYNFPAGGVGMGMY 222
Query: 183 NTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKTCG 242
NTD+SI FA SCF++++ +KWPLYLSTKNTI+K YDGRFKDIF E++ Y+T F
Sbjct: 223 NTDESISGFAHSCFQYSIQKKWPLYLSTKNTIMKAYDGRFKDIFQEIFDKHYKTDFDKNK 282
Query: 243 IFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGKTV 302
I+YEHRLIDDMVA ++S GG+VWACKNYDGDVQSD LAQGFGSLG+MTS+L+ PDGKT+
Sbjct: 283 IWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTI 342
Query: 303 EVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLEDVI 362
E EAAHGTVTRHYR++QKG+ TSTNP+ASIFAWTR L HR ++D N L+ F Q LE V
Sbjct: 343 EAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQTLEKVC 402
Query: 363 IATIEAGAMTEDLAICIKGEKNVV-RADYLNTDEFIDAVSQRLKVAMQKS 411
+ T+E+GAMT+DLA CI G NV +LNT +F+D + L A+ K
Sbjct: 403 VQTVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRALGKQ 452
>gb|AAH93020.1| Isocitrate dehydrogenase 1 (NADP+), soluble [Homo sapiens]
Length = 414
Score = 731 bits (1888), Expect = 0.0, Method: Composition-based stats.
Identities = 272/414 (65%), Positives = 332/414 (80%), Gaps = 1/414 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M+K + G +VE+ GDEMTR+IW+ IKE LIFP+V + + YDL +ENRD T D+VT +A
Sbjct: 1 MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIKKH VGVKCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 61 AEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYK-SGGVMM 179
V+ W KP++IGRHA+GDQY ATD VV PG E+ + P++G + Y V +++ GGV M
Sbjct: 121 VSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAM 180
Query: 180 GMYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFK 239
GMYN D SI DFA S F+ AL++ WPLYLSTKNTILK YDGRFKDIF E+Y Y+++F+
Sbjct: 181 GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE 240
Query: 240 TCGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDG 299
I+YEHRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDG
Sbjct: 241 AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG 300
Query: 300 KTVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLE 359
KTVE E+AHGTVTRHYR YQKG+ETSTNP+ASIFAWTR LAHRA++DNN L F LE
Sbjct: 301 KTVEAESAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALE 360
Query: 360 DVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
+V I TIEAG MT+DLA CIKG NV R+DYLNT EF+D + + LK+ + ++K+
Sbjct: 361 EVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL 414
>emb|CAM77136.1| Isocitrate/isopropylmalate dehydrogenase [Magnetospirillum
gryphiswaldense MSR-1]
Length = 405
Score = 731 bits (1888), Expect = 0.0, Method: Composition-based stats.
Identities = 260/409 (63%), Positives = 323/409 (78%), Gaps = 6/409 (1%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
MNKI +VELDGDEMTR+IWK IK+ LI P+++V ++YYDL +E RD+T D+VT++A
Sbjct: 1 MNKIKVANPIVELDGDEMTRIIWKFIKDKLILPYLDVDLKYYDLGVEYRDETNDQVTIDA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIK++GVGVKCATITPDEARVKEFNLKKMW+SPNGTIR IL GTVFREPIIC NVPRL
Sbjct: 61 AEAIKQYGVGVKCATITPDEARVKEFNLKKMWKSPNGTIRNILDGTVFREPIICQNVPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGGVMMG 180
V W KP+VIGRHAFGDQY ATD V PG M+F+ +G + ++VF++ S GV MG
Sbjct: 121 VPGWTKPIVIGRHAFGDQYRATDFKVPGPGILTMKFVGEDG-QVIEHEVFNFPSSGVAMG 179
Query: 181 MYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKT 240
MYN D+SIR FAR+C + LA+KWP+YLSTKNTILK YDGRFKDIF E+Y+ ++ +F
Sbjct: 180 MYNLDESIRGFARACMNYGLAKKWPVYLSTKNTILKAYDGRFKDIFQEVYEKEFKAEFDK 239
Query: 241 CGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGK 300
G+ YEHRLIDDMVA ++ G +VWACKNYDGDVQSD++AQGFGSLG+MTS+L++PDGK
Sbjct: 240 YGMTYEHRLIDDMVASALKWSGEFVWACKNYDGDVQSDTVAQGFGSLGLMTSVLLSPDGK 299
Query: 301 TVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLED 360
TVE EAAHGTVTRHYR++QKGKETSTNP+ASIFAWTR L +RA+ DN + +F LE+
Sbjct: 300 TVEAEAAHGTVTRHYREHQKGKETSTNPIASIFAWTRGLLYRAQFDNTPEVAKFATALEE 359
Query: 361 VIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQ 409
V + T+EAG MT+DLAI I ++ +L T +F+D + + LK M
Sbjct: 360 VCVETVEAGFMTKDLAILIGPDQ-----PWLTTTQFLDKLDENLKKKMG 403
>ref|XP_001505172.1| PREDICTED: similar to Isocitrate dehydrogenase [NADP] cytoplasmic
(Cytosolic NADP-isocitrate dehydrogenase)
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) (IDP) [Equus caballus]
Length = 414
Score = 731 bits (1887), Expect = 0.0, Method: Composition-based stats.
Identities = 271/414 (65%), Positives = 331/414 (79%), Gaps = 1/414 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M++ G +VE+ GDEMTR+IW+ IKE LIFP V + + YDL +ENRD T D+VT +A
Sbjct: 1 MSQKIRGGSVVEMQGDEMTRIIWELIKEKLIFPHVELDLHSYDLGIENRDATNDQVTKDA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIKK+ VGVKCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 61 AEAIKKYNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYK-SGGVMM 179
V+ W KP++IGRHA+GDQY ATD VV PG E+ + P++G + + Y V +++ GGV M
Sbjct: 121 VSGWVKPIIIGRHAYGDQYRATDFVVPGPGRVEITYTPSDGSQKRTYLVHNFEEGGGVAM 180
Query: 180 GMYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFK 239
GMYN D SI DFA S F+ AL++ WPLYLSTKNTILK YDGRFKDIF E+Y Y ++F+
Sbjct: 181 GMYNQDKSIEDFAHSSFQMALSKSWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYRSQFE 240
Query: 240 TCGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDG 299
I+YEHRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDG
Sbjct: 241 AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG 300
Query: 300 KTVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLE 359
KTVE EAAHGTVTRHYR YQKG+ETSTNP+ASIFAWTR LAHRA++DNN L F + LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELGFFAKALE 360
Query: 360 DVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
DV + TIEAG MT+DLA CIKG NV R+DYLNT EF+D + + LK+ + ++K+
Sbjct: 361 DVCVETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL 414
>pdb|1LWD|A Chain A, Crystal Structure Of Nadp-Dependent Isocitrate
Dehydrogenase From Porcine Heart Mitochondria
pdb|1LWD|B Chain B, Crystal Structure Of Nadp-Dependent Isocitrate
Dehydrogenase From Porcine Heart Mitochondria
Length = 413
Score = 731 bits (1887), Expect = 0.0, Method: Composition-based stats.
Identities = 256/411 (62%), Positives = 321/411 (78%), Gaps = 1/411 (0%)
Query: 2 NKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEAA 61
+I +VE+DGDEMTR+IW+ IKE LI P V+V ++Y+DL + NRD+T D+VT+++A
Sbjct: 3 QRIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDVQLKYFDLGLPNRDQTNDQVTIDSA 62
Query: 62 YAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRLV 121
A +K+ V VKCATITPDEARV+EF LKKMW+SPNGTIR ILGGTVFREPIIC N+PRLV
Sbjct: 63 LATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLV 122
Query: 122 TTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGGVMMGM 181
W KP+ IGRHA GDQY ATD VV GTF++ F P +G K ++V+++ +GGV MGM
Sbjct: 123 PGWTKPITIGRHAHGDQYKATDFVVDRAGTFKIVFTPKDGSSAKQWEVYNFPAGGVGMGM 182
Query: 182 YNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKTC 241
YNTD+SI FA SCF++A+ +KWPLY+STKNTILK YDGRFKDIF E+++ Y+T F
Sbjct: 183 YNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFEKHYKTDFDKY 242
Query: 242 GIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGKT 301
I+YEHRLIDDMVA ++S GG+VWACKNYDGDVQSD LAQGFGSLG+MTS+L+ PDGKT
Sbjct: 243 KIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKT 302
Query: 302 VEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLEDV 361
+E EAAHGTVTRHYR++QKG+ TSTNP+ASIFAWTR L HR ++D N L+ F Q LE V
Sbjct: 303 IEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQTLEKV 362
Query: 362 IIATIEAGAMTEDLAICIKGEKNVV-RADYLNTDEFIDAVSQRLKVAMQKS 411
+ T+E+GAMT+DLA CI G NV +LNT +F+D + L A+ +
Sbjct: 363 CVETVESGAMTKDLAGCIHGLSNVKLNEHFLNTSDFLDTIKSNLDRALGRQ 413
>ref|XP_001095686.1| PREDICTED: isocitrate dehydrogenase 2 (NADP+), mitochondrial
[Macaca mulatta]
sp|Q4R502|IDHP_MACFA Isocitrate dehydrogenase [NADP], mitochondrial precursor
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) (IDP) (ICD-M)
dbj|BAE01823.1| unnamed protein product [Macaca fascicularis]
Length = 452
Score = 731 bits (1887), Expect = 0.0, Method: Composition-based stats.
Identities = 255/410 (62%), Positives = 320/410 (78%), Gaps = 1/410 (0%)
Query: 3 KISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEAAY 62
+I +VE+DGDEMTR+IW+ IKE LI P V++ ++Y+DL + NRD+T+D+VT+++A
Sbjct: 43 RIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSAL 102
Query: 63 AIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRLVT 122
A +K+ V VKCATITPDEARV+EF LKKMW+SPNGTIR ILGGTVFREPIIC N+PRLV
Sbjct: 103 ATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVP 162
Query: 123 TWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGGVMMGMY 182
W KP+ IGRHA GDQY ATD V GTF+M F P +G K ++V+++ +GGV MGMY
Sbjct: 163 GWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMY 222
Query: 183 NTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKTCG 242
NTD+SI FA SCF++A+ +KWPLY+STKNTILK YDGRFKDIF E++ Y+T F
Sbjct: 223 NTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNK 282
Query: 243 IFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGKTV 302
I+YEHRLIDDMVA ++S GG+VWACKNYDGDVQSD LAQGFGSLG+MTS+L+ PDGKT+
Sbjct: 283 IWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTI 342
Query: 303 EVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLEDVI 362
E EAAHGTVTRHYR++QKG+ TSTNP+ASIFAWTR L HR ++D N L+ F Q LE V
Sbjct: 343 EAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQTLEKVC 402
Query: 363 IATIEAGAMTEDLAICIKGEKNVV-RADYLNTDEFIDAVSQRLKVAMQKS 411
+ T+E+GAMT+DLA CI G NV +LNT +F+D + L A+ +
Sbjct: 403 VETVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRALGRQ 452
>ref|NP_001088022.1| hypothetical protein LOC494713 [Xenopus laevis]
gb|AAH82651.1| LOC494713 protein [Xenopus laevis]
Length = 415
Score = 730 bits (1886), Expect = 0.0, Method: Composition-based stats.
Identities = 270/410 (65%), Positives = 329/410 (80%), Gaps = 1/410 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M+K G +VE+ GDEMTRVIW IKE LI P+V + + YDL MENRD T+D+VTV+A
Sbjct: 1 MSKKINGGSVVEMQGDEMTRVIWDLIKEKLILPYVELDLHSYDLGMENRDATDDQVTVDA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIKK+ VG+KCATITPDE RV+EFNLK+MW+SPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 61 AEAIKKYNVGIKCATITPDEKRVEEFNLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKS-GGVMM 179
V+ W KP++IGRHA+GDQY ATD VV PG E+ F P +GGE Y + +++ GGV +
Sbjct: 121 VSGWIKPIIIGRHAYGDQYRATDFVVPGPGKVEISFTPKDGGEAIKYVIHNFEDCGGVAL 180
Query: 180 GMYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFK 239
GMYNTD SIRDFA S F+ AL++ WPLY+STKNTILK YDGRFKDIF E+Y+ Y+++F+
Sbjct: 181 GMYNTDQSIRDFAHSSFQMALSKSWPLYMSTKNTILKRYDGRFKDIFQEIYEKEYKSQFE 240
Query: 240 TCGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDG 299
I+YEHRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDG
Sbjct: 241 ENKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDG 300
Query: 300 KTVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLE 359
KTVE EAAHGTVTRHYR +QKG+ETSTNP+ASIFAW+R L HRA++DNN L F LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMHQKGQETSTNPIASIFAWSRGLDHRAKLDNNQELKNFATALE 360
Query: 360 DVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQ 409
+V I TIEAG MT+DLA CIKG NV R DYL+T EF+D + + L++ +
Sbjct: 361 EVCIETIEAGFMTKDLAACIKGLPNVQRGDYLSTFEFMDKLGENLQLKLA 410
>emb|CAD97653.1| hypothetical protein [Homo sapiens]
emb|CAL38069.1| hypothetical protein [synthetic construct]
emb|CAL37462.1| hypothetical protein [synthetic construct]
Length = 414
Score = 730 bits (1886), Expect = 0.0, Method: Composition-based stats.
Identities = 273/414 (65%), Positives = 331/414 (79%), Gaps = 1/414 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M+K + G +VE+ GDEMTR+IW+ IKE LIFP+V + + YDL +ENRD T D+VT +A
Sbjct: 1 MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIKKH VGVKCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 61 AEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGG-VMM 179
V+ W KP++IGRHA+GDQY ATD VV PG E+ + P++G + Y V + + GG V M
Sbjct: 121 VSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNSEGGGGVAM 180
Query: 180 GMYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFK 239
GMYN D SI DFA S F+ AL++ WPLYLSTKNTILK YDGRFKDIF E+Y Y+++F+
Sbjct: 181 GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE 240
Query: 240 TCGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDG 299
I+YEHRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDG
Sbjct: 241 AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG 300
Query: 300 KTVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLE 359
KTVE EAAHGTVTRHYR YQKG+ETSTNP+ASIFAWTR LAHRA++DNN L F LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALE 360
Query: 360 DVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
+V I TIEAG MT+DLA CIKG NV R+DYLNT EF+D + + LK+ + ++K+
Sbjct: 361 EVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL 414
>sp|P33198|IDHP_PIG Isocitrate dehydrogenase [NADP], mitochondrial precursor
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) (IDP) (ICD-M)
gb|AAA31089.1| NADPH-specific isocitrate dehydrogenase
Length = 421
Score = 730 bits (1886), Expect = 0.0, Method: Composition-based stats.
Identities = 256/411 (62%), Positives = 321/411 (78%), Gaps = 1/411 (0%)
Query: 2 NKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEAA 61
+I +VE+DGDEMTR+IW+ IKE LI P V+V ++Y+DL + NRD+T D+VT+++A
Sbjct: 11 QRIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDVQLKYFDLGLPNRDQTNDQVTIDSA 70
Query: 62 YAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRLV 121
A +K+ V VKCATITPDEARV+EF LKKMW+SPNGTIR ILGGTVFREPIIC N+PRLV
Sbjct: 71 LATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLV 130
Query: 122 TTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGGVMMGM 181
W KP+ IGRHA GDQY ATD VV GTF++ F P +G K ++V+++ +GGV MGM
Sbjct: 131 PGWTKPITIGRHAHGDQYKATDFVVDRAGTFKIVFTPKDGSSAKQWEVYNFPAGGVGMGM 190
Query: 182 YNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKTC 241
YNTD+SI FA SCF++A+ +KWPLY+STKNTILK YDGRFKDIF E+++ Y+T F
Sbjct: 191 YNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFEKHYKTDFDKY 250
Query: 242 GIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGKT 301
I+YEHRLIDDMVA ++S GG+VWACKNYDGDVQSD LAQGFGSLG+MTS+L+ PDGKT
Sbjct: 251 KIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKT 310
Query: 302 VEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLEDV 361
+E EAAHGTVTRHYR++QKG+ TSTNP+ASIFAWTR L HR ++D N L+ F Q LE V
Sbjct: 311 IEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQTLEKV 370
Query: 362 IIATIEAGAMTEDLAICIKGEKNVV-RADYLNTDEFIDAVSQRLKVAMQKS 411
+ T+E+GAMT+DLA CI G NV +LNT +F+D + L A+ +
Sbjct: 371 CVETVESGAMTKDLAGCIHGLSNVKLNEHFLNTSDFLDTIKSNLDRALGRQ 421
>gb|ACO14046.1| Isocitrate dehydrogenase, mitochondrial precursor [Esox lucius]
Length = 451
Score = 730 bits (1885), Expect = 0.0, Method: Composition-based stats.
Identities = 253/409 (61%), Positives = 321/409 (78%), Gaps = 1/409 (0%)
Query: 3 KISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEAAY 62
+I + +VE+DGDEMTR+IW+ IKE LI V+V ++YYDL + RD+T D+VT+++A
Sbjct: 43 RIKVSQPVVEMDGDEMTRIIWEFIKEKLILSNVDVELKYYDLGLPYRDQTNDQVTIDSAL 102
Query: 63 AIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRLVT 122
A +K+ V VKCATITPDEARV+EF LKKMW+SPNGTIR ILGGTVFREPIIC N+PRLV
Sbjct: 103 ATQKYHVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVP 162
Query: 123 TWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGGVMMGMY 182
W +P+ IGRHAFGDQY ATD VV +PGTF+M F P +G + + + V+++ GG MGMY
Sbjct: 163 GWTQPITIGRHAFGDQYRATDFVVNQPGTFKMVFSPTDGSKGQEWGVYNFPGGGCGMGMY 222
Query: 183 NTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKTCG 242
NTD+SI FA SCF++A+ +KWPLYLSTKNTILK YDGRFKDIF E+++A Y+ +F
Sbjct: 223 NTDESISGFAHSCFQYAIGKKWPLYLSTKNTILKAYDGRFKDIFEEIFQANYKPEFDKLK 282
Query: 243 IFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGKTV 302
I+YEHRLIDDMVA ++S+G +VWACKNYDGDVQSD LAQGFGSLG+MTS+L+ PDGKT+
Sbjct: 283 IWYEHRLIDDMVAQVLKSDGAFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTI 342
Query: 303 EVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLEDVI 362
E EAAHGTVTRHYR++QKG TSTNP+ASIFAWTR L HR ++D N L++F LE V
Sbjct: 343 EAEAAHGTVTRHYREHQKGNPTSTNPIASIFAWTRGLEHRGKLDGNPDLIKFALTLERVC 402
Query: 363 IATIEAGAMTEDLAICIKGEKNVV-RADYLNTDEFIDAVSQRLKVAMQK 410
+ T+E+G MT+DLA CI G Y+NT++F+DA+ + L A+ K
Sbjct: 403 VETVESGVMTKDLAGCIHGLSKCKLNEHYVNTEDFLDAIKKNLDKALGK 451
>emb|CAH89719.1| hypothetical protein [Pongo abelii]
Length = 414
Score = 730 bits (1884), Expect = 0.0, Method: Composition-based stats.
Identities = 271/414 (65%), Positives = 332/414 (80%), Gaps = 1/414 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M+K + G +VE+ GDEMTR+IW++IKE LIFP+V + + YDL +ENRD T D+VT +A
Sbjct: 1 MSKKISGGSVVEMQGDEMTRIIWEQIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIKK+ VGVKCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 61 AEAIKKYNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYK-SGGVMM 179
V+ W KP++IGRHA+GDQY ATD VV PG E+ + P++G + Y V +++ GGV M
Sbjct: 121 VSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAM 180
Query: 180 GMYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFK 239
GMYN D SI DFA S F+ AL++ WPLYLSTKNTILK YDGRFKDIF E+Y Y+++F+
Sbjct: 181 GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE 240
Query: 240 TCGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDG 299
I+YEHRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDG
Sbjct: 241 ARKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG 300
Query: 300 KTVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLE 359
KTVE EAAHGTVTRHYR YQKG+ETSTNP+ASIFAWTR LAHRA++DNN L F LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALE 360
Query: 360 DVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
+V + TIEAG MT+DLA CIKG NV R+DYLNT EF+D + + LK+ + +K+
Sbjct: 361 EVSVETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLALAKL 414
>ref|NP_002159.2| isocitrate dehydrogenase 2 (NADP+), mitochondrial precursor [Homo
sapiens]
sp|P48735|IDHP_HUMAN Isocitrate dehydrogenase [NADP], mitochondrial precursor
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) (IDP) (ICD-M)
gb|AAH09244.1| Isocitrate dehydrogenase 2 (NADP+), mitochondrial [Homo sapiens]
gb|AAH71828.1| Isocitrate dehydrogenase 2 (NADP+), mitochondrial [Homo sapiens]
gb|EAX02082.1| isocitrate dehydrogenase 2 (NADP+), mitochondrial, isoform CRA_a
[Homo sapiens]
gb|ABM83743.1| isocitrate dehydrogenase 2 (NADP+), mitochondrial [synthetic
construct]
gb|ABM87062.1| isocitrate dehydrogenase 2 (NADP+), mitochondrial [synthetic
construct]
Length = 452
Score = 730 bits (1884), Expect = 0.0, Method: Composition-based stats.
Identities = 255/410 (62%), Positives = 320/410 (78%), Gaps = 1/410 (0%)
Query: 3 KISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEAAY 62
+I +VE+DGDEMTR+IW+ IKE LI P V++ ++Y+DL + NRD+T+D+VT+++A
Sbjct: 43 RIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSAL 102
Query: 63 AIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRLVT 122
A +K+ V VKCATITPDEARV+EF LKKMW+SPNGTIR ILGGTVFREPIIC N+PRLV
Sbjct: 103 ATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVP 162
Query: 123 TWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGGVMMGMY 182
W KP+ IGRHA GDQY ATD V GTF+M F P +G K ++V+++ +GGV MGMY
Sbjct: 163 GWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMY 222
Query: 183 NTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKTCG 242
NTD+SI FA SCF++A+ +KWPLY+STKNTILK YDGRFKDIF E++ Y+T F
Sbjct: 223 NTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNK 282
Query: 243 IFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGKTV 302
I+YEHRLIDDMVA ++S GG+VWACKNYDGDVQSD LAQGFGSLG+MTS+L+ PDGKT+
Sbjct: 283 IWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTI 342
Query: 303 EVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLEDVI 362
E EAAHGTVTRHYR++QKG+ TSTNP+ASIFAWTR L HR ++D N L+ F Q LE V
Sbjct: 343 EAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQMLEKVC 402
Query: 363 IATIEAGAMTEDLAICIKGEKNVV-RADYLNTDEFIDAVSQRLKVAMQKS 411
+ T+E+GAMT+DLA CI G NV +LNT +F+D + L A+ +
Sbjct: 403 VETVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRALGRQ 452
>ref|NP_955858.1| isocitrate dehydrogenase 2 (NADP+), mitochondrial [Danio rerio]
gb|AAH48041.1| Isocitrate dehydrogenase 2 (NADP+), mitochondrial [Danio rerio]
gb|AAH63967.1| Isocitrate dehydrogenase 2 (NADP+), mitochondrial [Danio rerio]
Length = 449
Score = 730 bits (1884), Expect = 0.0, Method: Composition-based stats.
Identities = 255/409 (62%), Positives = 321/409 (78%), Gaps = 1/409 (0%)
Query: 3 KISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEAAY 62
+I +VE+DGDEMTR+IW+ IKE LI VNV ++YYDL + RD+T+D+VT+++A
Sbjct: 41 RIQVAQPVVEMDGDEMTRIIWEFIKEKLILTNVNVDLKYYDLGLPYRDQTDDQVTIDSAI 100
Query: 63 AIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRLVT 122
A KK+ V VKCATITPDEARV+EF LKKMW+SPNGTIR ILGGTVFREPIIC N+PRLV
Sbjct: 101 ATKKYNVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVP 160
Query: 123 TWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGGVMMGMY 182
W + + IGRHAFGDQY ATD VV +PG F+M F PA+G + K ++V+D+ GG MGMY
Sbjct: 161 GWTQAITIGRHAFGDQYKATDFVVNQPGKFKMVFTPADGSKNKEWEVYDFPGGGCGMGMY 220
Query: 183 NTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKTCG 242
NTD+SI FA SCF++A+ +KWPLY+STKNTILK YDGRFKDIF ++++ Y+ +F
Sbjct: 221 NTDESITGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQDIFEKNYKPEFDKLK 280
Query: 243 IFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGKTV 302
I+YEHRLIDDMVA ++S G +VWACKNYDGDVQSD LAQGFGSLG+MTS+L+ PDGKT+
Sbjct: 281 IWYEHRLIDDMVAQVLKSSGAFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTI 340
Query: 303 EVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLEDVI 362
E EAAHGTVTRHYR++QKG+ TSTNP+ASIFAWTR L HR ++D N L++F+Q LE V
Sbjct: 341 EAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNPDLIKFSQTLERVC 400
Query: 363 IATIEAGAMTEDLAICIKGEKNVV-RADYLNTDEFIDAVSQRLKVAMQK 410
+ T+E+G MT+DLA CI G N Y+NT +F+DA+ L A+ K
Sbjct: 401 VETVESGVMTKDLAGCIHGLANCKLNEHYVNTTDFLDAIKTNLDKALGK 449
>emb|CAB66637.1| hypothetical protein [Homo sapiens]
emb|CAL37490.1| hypothetical protein [synthetic construct]
Length = 414
Score = 729 bits (1883), Expect = 0.0, Method: Composition-based stats.
Identities = 271/414 (65%), Positives = 331/414 (79%), Gaps = 1/414 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M+K + G +VE+ GDEMTR+IW+ IKE LI P+V + + YDL +ENRD T D+VT +A
Sbjct: 1 MSKKISGGSVVEMQGDEMTRIIWELIKEKLIIPYVELDLHSYDLGIENRDATNDQVTKDA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIKKH VGVKCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 61 AEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYK-SGGVMM 179
V+ W +P++IGRHA+GDQY ATD VV PG E+ + P++G + Y V +++ GGV M
Sbjct: 121 VSGWVEPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAM 180
Query: 180 GMYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFK 239
GMYN D SI DFA S F+ AL++ WPLYLSTKNTILK YDGRFKDIF E+Y Y+++F+
Sbjct: 181 GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE 240
Query: 240 TCGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDG 299
I+YEHRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDG
Sbjct: 241 AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG 300
Query: 300 KTVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLE 359
KTVE EAAHGTVTRHYR YQKG+ETSTNP+ASIFAWTR LAHRA++DNN L F LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALE 360
Query: 360 DVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
+V I TIEAG MT+DLA CIKG NV R+DYLNT EF+D + + LK+ + ++K+
Sbjct: 361 EVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL 414
>sp|O88844|IDHC_MOUSE Isocitrate dehydrogenase [NADP] cytoplasmic (Cytosolic
NADP-isocitrate dehydrogenase) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP)
gb|AAD02919.1| NADP-dependent isocitrate dehydrogenase [Mus musculus]
Length = 414
Score = 729 bits (1883), Expect = 0.0, Method: Composition-based stats.
Identities = 272/414 (65%), Positives = 328/414 (79%), Gaps = 1/414 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M++ G +VE+ GDEMTR+IW+ IKE LI P+V + + YDL +ENRD T D+VT +A
Sbjct: 1 MSRKIQGGSVVEMQGDEMTRIIWELIKEKLILPYVELDLHSYDLGIENRDATNDQVTKDA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIKK+ VGVKCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 61 AEAIKKYNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYK-SGGVMM 179
VT W KP++IGRHA+GDQY ATD VV PG E+ + P +G + Y V D++ GGV M
Sbjct: 121 VTGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPKDGTQKVTYMVHDFEEGGGVAM 180
Query: 180 GMYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFK 239
GMYN D SI DFA S F+ AL++ WPLYLSTKNTILK YDGRFKDIF E+Y Y+++F+
Sbjct: 181 GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKKYKSQFE 240
Query: 240 TCGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDG 299
I YEHRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDG
Sbjct: 241 AQNICYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDG 300
Query: 300 KTVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLE 359
KTVE EAAHGTVTRHYR YQKG+ETSTNP+ASIFAW+R LAHRA++DNN L F + LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWSRGLAHRAKLDNNTELSFFAKALE 360
Query: 360 DVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
DV I TIEAG MT+DLA CIKG NV R+DYLNT EF+D + + LK + ++K+
Sbjct: 361 DVCIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKAKLAQAKL 414
>emb|CAA49208.1| isocitrate dehydrogenase (NADP+) [Homo sapiens]
Length = 452
Score = 729 bits (1882), Expect = 0.0, Method: Composition-based stats.
Identities = 255/410 (62%), Positives = 320/410 (78%), Gaps = 1/410 (0%)
Query: 3 KISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEAAY 62
+I +VE+DGDEMTR+IW+ IKE LI P V++ ++Y+DL + NRD+T+D+VT+++A
Sbjct: 43 RIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSAL 102
Query: 63 AIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRLVT 122
A +K+ V VKCATITPDEARV+EF LKKMW+SPNGTIR ILGGTVFREPIIC N+PRLV
Sbjct: 103 ATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVP 162
Query: 123 TWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGGVMMGMY 182
W KP+ IGRHA GDQY ATD V GTF+M F P +G K ++V+++ +GGV MGMY
Sbjct: 163 GWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMY 222
Query: 183 NTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKTCG 242
NTD+SI FA SCF++A+ +KWPLY+STKNTILK YDGRFKDIF E++ Y+T F
Sbjct: 223 NTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNK 282
Query: 243 IFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGKTV 302
I+YEHRLIDDMVA ++S GG+VWACKNYDGDVQSD LAQGFGSLG+MTS+L+ PDGKT+
Sbjct: 283 IWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTI 342
Query: 303 EVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLEDVI 362
E EAAHGTVTRHYR++QKG+ TSTNP+ASIFAWTR L HR ++D N L+ F Q LE V
Sbjct: 343 EAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQMLEKVC 402
Query: 363 IATIEAGAMTEDLAICIKGEKNVV-RADYLNTDEFIDAVSQRLKVAMQKS 411
+ T+E+GAMT+DLA CI G NV +LNT +F+D + L A+ +
Sbjct: 403 VETVESGAMTKDLAGCIHGLSNVKLNEHFLNTMDFLDTIKSNLDRALGRQ 452
>dbj|BAD96636.1| isocitrate dehydrogenase 2 (NADP+), mitochondrial precursor variant
[Homo sapiens]
Length = 452
Score = 729 bits (1882), Expect = 0.0, Method: Composition-based stats.
Identities = 256/410 (62%), Positives = 320/410 (78%), Gaps = 1/410 (0%)
Query: 3 KISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEAAY 62
+I +VE+DGDEMTR+IW+ IKE LI P V++ ++Y+DL + NRD+T+D+VT+++A
Sbjct: 43 RIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSAL 102
Query: 63 AIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRLVT 122
A +K+ V VKCATITPDEARV+EF LKKMW+SPNGTIR ILGGTVFREPIIC N+PRLV
Sbjct: 103 ATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVP 162
Query: 123 TWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGGVMMGMY 182
W KP+ IGRHA GDQY ATD V GTF+M F P +G K ++V+++ +GGV MGMY
Sbjct: 163 GWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMY 222
Query: 183 NTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKTCG 242
NTD+SI FA SCF++A+ +KWPLY+STKNTILK YDGRFKDIF E++ YET F
Sbjct: 223 NTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYETDFDKNK 282
Query: 243 IFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGKTV 302
I+YEHRLIDDMVA ++S GG+VWACKNYDGDVQSD LAQGFGSLG+MTS+L+ PDGKT+
Sbjct: 283 IWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTI 342
Query: 303 EVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLEDVI 362
E EAAHGTVTRHYR++QKG+ TSTNP+ASIFAWTR L HR ++D N L+ F Q LE V
Sbjct: 343 EAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQMLEKVC 402
Query: 363 IATIEAGAMTEDLAICIKGEKNVV-RADYLNTDEFIDAVSQRLKVAMQKS 411
+ T+E+GAMT+DLA CI G NV +LNT +F+D + L A+ +
Sbjct: 403 VETVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRALGRQ 452
>emb|CAH91635.1| hypothetical protein [Pongo abelii]
Length = 414
Score = 728 bits (1880), Expect = 0.0, Method: Composition-based stats.
Identities = 269/414 (64%), Positives = 330/414 (79%), Gaps = 1/414 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M+K + G +VE+ GDEMTR+IW+ IKE LIFP+V + + YDL +ENRD T D+VT +A
Sbjct: 1 MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIKK+ VGVKCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 61 AEAIKKYNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYK-SGGVMM 179
V+ W KP++IGRHA+GDQY ATD VV PG E+ + P++G + Y V +++ GGV M
Sbjct: 121 VSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAM 180
Query: 180 GMYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFK 239
GMYN D SI DFA S F+ AL++ WPLYLSTKNTILK YDGRFKD F E+Y Y+++F+
Sbjct: 181 GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDTFQEIYDKQYKSQFE 240
Query: 240 TCGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDG 299
I+YEHRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDG
Sbjct: 241 ARKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG 300
Query: 300 KTVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLE 359
KTVE EAAHGTVTRHYR YQKG+ETSTNP+ SIFAWTR LAHRA++DNN L F LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMYQKGQETSTNPIVSIFAWTRGLAHRAKLDNNKELAFFANALE 360
Query: 360 DVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
+V + TIEAG MT+DLA CIKG NV R+DYLNT EF+D + + LK+ + ++K+
Sbjct: 361 EVSVETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL 414
>ref|NP_034627.3| isocitrate dehydrogenase 1 (NADP+), soluble [Mus musculus]
ref|NP_001104790.1| isocitrate dehydrogenase 1 (NADP+), soluble [Mus musculus]
dbj|BAE36075.1| unnamed protein product [Mus musculus]
dbj|BAE30207.1| unnamed protein product [Mus musculus]
dbj|BAE39299.1| unnamed protein product [Mus musculus]
dbj|BAE34873.1| unnamed protein product [Mus musculus]
dbj|BAE28720.1| unnamed protein product [Mus musculus]
gb|EDL00223.1| isocitrate dehydrogenase 1 (NADP+), soluble, isoform CRA_a [Mus
musculus]
gb|EDL00225.1| isocitrate dehydrogenase 1 (NADP+), soluble, isoform CRA_a [Mus
musculus]
Length = 414
Score = 728 bits (1880), Expect = 0.0, Method: Composition-based stats.
Identities = 272/414 (65%), Positives = 328/414 (79%), Gaps = 1/414 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M++ G +VE+ GDEMTR+IW+ IKE LI P+V + + YDL +ENRD T D+VT +A
Sbjct: 1 MSRKIQGGSVVEMQGDEMTRIIWELIKEKLILPYVELDLHSYDLGIENRDATNDQVTKDA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIKK+ VGVKCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 61 AEAIKKYNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYK-SGGVMM 179
VT W KP++IGRHA+GDQY ATD VV PG E+ + P +G + Y V D++ GGV M
Sbjct: 121 VTGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPKDGTQKVTYMVHDFEEGGGVAM 180
Query: 180 GMYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFK 239
GMYN D SI DFA S F+ AL++ WPLYLSTKNTILK YDGRFKDIF E+Y Y+++F+
Sbjct: 181 GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKKYKSQFE 240
Query: 240 TCGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDG 299
I YEHRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDG
Sbjct: 241 AQKICYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDG 300
Query: 300 KTVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLE 359
KTVE EAAHGTVTRHYR YQKG+ETSTNP+ASIFAW+R LAHRA++DNN L F + LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWSRGLAHRAKLDNNTELSFFAKALE 360
Query: 360 DVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
DV I TIEAG MT+DLA CIKG NV R+DYLNT EF+D + + LK + ++K+
Sbjct: 361 DVCIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKAKLAQAKL 414
>dbj|BAE39644.1| unnamed protein product [Mus musculus]
Length = 414
Score = 727 bits (1878), Expect = 0.0, Method: Composition-based stats.
Identities = 272/414 (65%), Positives = 328/414 (79%), Gaps = 1/414 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M++ G +VE+ GDEMTR+IW+ IKE LI P+V + + YDL +ENRD T D+VT +A
Sbjct: 1 MSRKIKGGSVVEMQGDEMTRIIWELIKEKLILPYVELDLHSYDLGIENRDATNDQVTKDA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIKK+ VGVKCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 61 AEAIKKYNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYK-SGGVMM 179
VT W KP++IGRHA+GDQY ATD VV PG E+ + P +G + Y V D++ GGV M
Sbjct: 121 VTGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPKDGTQKVTYMVHDFEEGGGVAM 180
Query: 180 GMYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFK 239
GMYN D SI DFA S F+ AL++ WPLYLSTKNTILK YDGRFKDIF E+Y Y+++F+
Sbjct: 181 GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKKYKSQFE 240
Query: 240 TCGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDG 299
I YEHRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDG
Sbjct: 241 AQKICYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDG 300
Query: 300 KTVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLE 359
KTVE EAAHGTVTRHYR YQKG+ETSTNP+ASIFAW+R LAHRA++DNN L F + LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWSRGLAHRAKLDNNTELSFFAKALE 360
Query: 360 DVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
DV I TIEAG MT+DLA CIKG NV R+DYLNT EF+D + + LK + ++K+
Sbjct: 361 DVCIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKAKLAQAKL 414
>dbj|BAC39792.1| unnamed protein product [Mus musculus]
Length = 422
Score = 727 bits (1878), Expect = 0.0, Method: Composition-based stats.
Identities = 271/413 (65%), Positives = 327/413 (79%), Gaps = 1/413 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M++ G +VE+ GDEMTR+IW+ IKE LI P+V + + YDL +ENRD T D+VT +A
Sbjct: 1 MSRKIQGGSVVEMQGDEMTRIIWELIKEKLILPYVELDLHSYDLGIENRDATNDQVTKDA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIKK+ VGVKCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 61 AEAIKKYNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYK-SGGVMM 179
VT W KP++IGRHA+GDQY ATD VV PG E+ + P +G + Y V D++ GGV M
Sbjct: 121 VTGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPKDGTQKVTYMVHDFEEGGGVAM 180
Query: 180 GMYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFK 239
GMYN D SI DFA S F+ AL++ WPLYLSTKNTILK YDGRFKDIF E+Y Y+++F+
Sbjct: 181 GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKKYKSQFE 240
Query: 240 TCGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDG 299
I YEHRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDG
Sbjct: 241 AQKICYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDG 300
Query: 300 KTVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLE 359
KTVE EAAHGTVTRHYR YQKG+ETSTNP+ASIFAW+R LAHRA++DNN L F + LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWSRGLAHRAKLDNNTELSFFAKALE 360
Query: 360 DVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSK 412
DV I TIEAG MT+DLA CIKG NV R+DYLNT EF+D + + LK + +++
Sbjct: 361 DVCIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKAKLAQAQ 413
>gb|AAH88986.1| Isocitrate dehydrogenase 1 (NADP+), soluble [Mus musculus]
Length = 414
Score = 727 bits (1877), Expect = 0.0, Method: Composition-based stats.
Identities = 271/414 (65%), Positives = 328/414 (79%), Gaps = 1/414 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M++ G +VE+ GDEMTR+IW+ IKE LI P+V + + YDL +ENRD T D+VT +A
Sbjct: 1 MSRKIQGGSVVEMQGDEMTRIIWELIKEKLILPYVELDLHSYDLGIENRDATNDQVTKDA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A A+KK+ VGVKCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 61 AEALKKYNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYK-SGGVMM 179
VT W KP++IGRHA+GDQY ATD VV PG E+ + P +G + Y V D++ GGV M
Sbjct: 121 VTGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPKDGTQKVTYMVHDFEEGGGVAM 180
Query: 180 GMYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFK 239
GMYN D SI DFA S F+ AL++ WPLYLSTKNTILK YDGRFKDIF E+Y Y+++F+
Sbjct: 181 GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKKYKSQFE 240
Query: 240 TCGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDG 299
I YEHRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDG
Sbjct: 241 AQKICYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDG 300
Query: 300 KTVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLE 359
KTVE EAAHGTVTRHYR YQKG+ETSTNP+ASIFAW+R LAHRA++DNN L F + LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWSRGLAHRAKLDNNTELSFFAKALE 360
Query: 360 DVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
DV I TIEAG MT+DLA CIKG NV R+DYLNT EF+D + + LK + ++K+
Sbjct: 361 DVCIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKAKLAQAKL 414
>ref|NP_539708.1| isocitrate dehydrogenase [Brucella melitensis 16M]
ref|YP_221903.1| isocitrate dehydrogenase [Brucella abortus biovar 1 str. 9-941]
ref|YP_414607.1| isocitrate dehydrogenase [Brucella melitensis biovar Abortus 2308]
ref|YP_001259118.1| isocitrate dehydrogenase [Brucella ovis ATCC 25840]
ref|YP_001935116.1| Isocitrate/isopropylmalate dehydrogenase [Brucella abortus S19]
gb|AAL51972.1| ISOCITRATE DEHYDROGENASE (NADP) [Brucella melitensis 16M]
gb|AAX74542.1| isocitrate dehydrogenase, NADP-dependent [Brucella abortus biovar 1
str. 9-941]
emb|CAJ11177.1| Isocitrate/isopropylmalate dehydrogenase:Isocitrate dehydrogenase
NADP-dependent, eukaryotic [Brucella melitensis biovar
Abortus 2308]
gb|ABQ61375.1| isocitrate dehydrogenase, NADP-dependent [Brucella ovis ATCC 25840]
gb|ACD72642.1| Isocitrate/isopropylmalate dehydrogenase [Brucella abortus S19]
Length = 404
Score = 726 bits (1876), Expect = 0.0, Method: Composition-based stats.
Identities = 252/409 (61%), Positives = 321/409 (78%), Gaps = 6/409 (1%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M KI +VELDGDEMTR+IW+ IK+ LI P++++ ++YYDLS+ENRD T D+VT++A
Sbjct: 1 MAKIKVANPVVELDGDEMTRIIWQFIKDKLIHPYLDIDLKYYDLSVENRDATNDQVTIDA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIK++GVGVKCATITPDEARV+EF LKKMW+SPNGTIR ILGG +FREPIIC NVPRL
Sbjct: 61 ANAIKEYGVGVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGVIFREPIICKNVPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGGVMMG 180
V W +P+++GRHAFGDQY ATD GT ++F+ +G + ++V+ S GV M
Sbjct: 121 VPGWTQPIIVGRHAFGDQYRATDFKFPGKGTLTIKFVGEDG-QTIEHEVYQAPSAGVAMA 179
Query: 181 MYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKT 240
MYN D+SIR+FAR+ F + L R +P+YLSTKNTILK YDGRFKDIF E++ A +++KF+
Sbjct: 180 MYNLDESIREFARASFNYGLQRGYPVYLSTKNTILKAYDGRFKDIFQEVFDAEFKSKFEE 239
Query: 241 CGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGK 300
I+YEHRLIDDMVA ++ GGYVWACKNYDGDVQSD +AQGFGSLG+MTS+LMTPDGK
Sbjct: 240 KKIWYEHRLIDDMVASALKWSGGYVWACKNYDGDVQSDIVAQGFGSLGLMTSVLMTPDGK 299
Query: 301 TVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLED 360
TVE EAAHGTVTRHYR +QKG+ETSTN +ASIFAWTR LAHRA++DNN L +F + LE
Sbjct: 300 TVEAEAAHGTVTRHYRQHQKGEETSTNSIASIFAWTRGLAHRAKLDNNADLKKFAETLEK 359
Query: 361 VIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQ 409
V + T+E+G MT+DLA+ I ++ +L+T F+D + + L+ AM
Sbjct: 360 VCVDTVESGFMTKDLALLIGPDQ-----PWLSTTGFLDKIDENLQKAMA 403
>ref|XP_001168316.1| PREDICTED: isocitrate dehydrogenase 2 (NADP+), mitochondrial
isoform 3 [Pan troglodytes]
Length = 415
Score = 726 bits (1876), Expect = 0.0, Method: Composition-based stats.
Identities = 255/410 (62%), Positives = 320/410 (78%), Gaps = 1/410 (0%)
Query: 3 KISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEAAY 62
+I +VE+DGDEMTR+IW+ IKE LI P V++ ++Y+DL + NRD+T+D+VT+++A
Sbjct: 6 RIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSAL 65
Query: 63 AIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRLVT 122
A +K+ V VKCATITPDEARV+EF LKKMW+SPNGTIR ILGGTVFREPIIC N+PRLV
Sbjct: 66 ATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVP 125
Query: 123 TWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGGVMMGMY 182
W KP+ IGRHA GDQY ATD V GTF+M F P +G K ++V+++ +GGV MGMY
Sbjct: 126 GWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMY 185
Query: 183 NTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKTCG 242
NTD+SI FA SCF++A+ +KWPLY+STKNTILK YDGRFKDIF E++ Y+T F
Sbjct: 186 NTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNK 245
Query: 243 IFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGKTV 302
I+YEHRLIDDMVA ++S GG+VWACKNYDGDVQSD LAQGFGSLG+MTS+L+ PDGKT+
Sbjct: 246 IWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTI 305
Query: 303 EVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLEDVI 362
E EAAHGTVTRHYR++QKG+ TSTNP+ASIFAWTR L HR ++D N L+ F Q LE V
Sbjct: 306 EAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQTLEKVC 365
Query: 363 IATIEAGAMTEDLAICIKGEKNVV-RADYLNTDEFIDAVSQRLKVAMQKS 411
+ T+E+GAMT+DLA CI G NV +LNT +F+D + L A+ +
Sbjct: 366 VETVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRALGRQ 415
>gb|AAD02918.1| NADP-dependent isocitrate dehydrogenase [Homo sapiens]
Length = 414
Score = 726 bits (1876), Expect = 0.0, Method: Composition-based stats.
Identities = 271/414 (65%), Positives = 331/414 (79%), Gaps = 1/414 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M+K + G +VE+ GDEMTR+IW+ IKE LIFP+V + + YDL +ENRD T D+VT +A
Sbjct: 1 MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIKKH VGVKCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 61 AEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYK-SGGVMM 179
V+ W KP++IGRHA+GDQY ATD VV PG E+ + P++G + Y V +++ GGV M
Sbjct: 121 VSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAM 180
Query: 180 GMYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFK 239
GMYN D SI DFA S F+ AL++ WPLYLSTKNTILK YDGRFKDIF E+Y Y+++F+
Sbjct: 181 GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKIYDGRFKDIFQEIYDKQYKSQFE 240
Query: 240 TCGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDG 299
I+YEHRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDG
Sbjct: 241 AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG 300
Query: 300 KTVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLE 359
KTVE EAAHGTVTRHYR YQKG+ETSTN +ASIFAWTR LAHRA++DNN L F LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMYQKGQETSTNLIASIFAWTRGLAHRAKLDNNKELAFFANALE 360
Query: 360 DVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
+V I TIEAG MT+DLA CI+G NV R+DYLNT EF+D + + LK+ + ++K+
Sbjct: 361 EVSIETIEAGFMTKDLAACIRGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL 414
Searching..................................................done
Results from round 3
Score E
Sequences producing significant alignments: (bits) Value
Sequences used in model and found again:
ref|XP_536192.2| PREDICTED: similar to isocitrate dehydroge... 719 0.0
ref|NP_001026770.1| hypothetical protein LOC431056 [Gallus ... 719 0.0
ref|NP_786984.1| isocitrate dehydrogenase 2 (NADP+), mitoch... 718 0.0
sp|Q04467|IDHP_BOVIN Isocitrate dehydrogenase [NADP], mitoc... 718 0.0
sp|P54071|IDHP_MOUSE Isocitrate dehydrogenase [NADP], mitoc... 716 0.0
ref|XP_001369305.1| PREDICTED: hypothetical protein [Monode... 716 0.0
ref|NP_766599.1| isocitrate dehydrogenase 2 (NADP+), mitoch... 715 0.0
ref|NP_001014183.1| isocitrate dehydrogenase 2 (NADP+), mit... 714 0.0
ref|XP_510589.2| PREDICTED: isocitrate dehydrogenase 2 (NAD... 714 0.0
ref|XP_001095686.1| PREDICTED: isocitrate dehydrogenase 2 (... 713 0.0
gb|ACO14046.1| Isocitrate dehydrogenase, mitochondrial prec... 713 0.0
gb|ABE98244.1| mitochondrial isocitrate dehydrogenase 2-lik... 713 0.0
ref|NP_002159.2| isocitrate dehydrogenase 2 (NADP+), mitoch... 712 0.0
ref|NP_955858.1| isocitrate dehydrogenase 2 (NADP+), mitoch... 712 0.0
pdb|1LWD|A Chain A, Crystal Structure Of Nadp-Dependent Iso... 712 0.0
sp|P33198|IDHP_PIG Isocitrate dehydrogenase [NADP], mitocho... 712 0.0
emb|CAA49208.1| isocitrate dehydrogenase (NADP+) [Homo sapi... 711 0.0
dbj|BAD96636.1| isocitrate dehydrogenase 2 (NADP+), mitocho... 711 0.0
ref|XP_001168316.1| PREDICTED: isocitrate dehydrogenase 2 (... 709 0.0
gb|EAX02083.1| isocitrate dehydrogenase 2 (NADP+), mitochon... 709 0.0
ref|NP_970434.1| isocitrate dehydrogenase [Bdellovibrio bac... 708 0.0
ref|XP_001107627.1| PREDICTED: isocitrate dehydrogenase 1 (... 708 0.0
ref|NP_851355.2| isocitrate dehydrogenase 1 (NADP+), solubl... 707 0.0
sp|Q9Z2K9|IDHC_MICME Isocitrate dehydrogenase [NADP] cytopl... 707 0.0
ref|NP_113698.1| isocitrate dehydrogenase 1 (NADP+), solubl... 706 0.0
ref|XP_421965.2| PREDICTED: similar to cytosolic NADP-depen... 706 0.0
emb|CAM77136.1| Isocitrate/isopropylmalate dehydrogenase [M... 706 0.0
sp|Q9Z2K8|IDHC_MICOH Isocitrate dehydrogenase [NADP] cytopl... 706 0.0
emb|CAG38738.1| IDH1 [Homo sapiens] 706 0.0
ref|NP_001009276.1| cytosolic NADP-isocitrate dehydrogenase... 706 0.0
ref|XP_850187.1| PREDICTED: similar to Isocitrate dehydroge... 705 0.0
ref|NP_005887.2| isocitrate dehydrogenase 1 (NADP+), solubl... 705 0.0
gb|ABU41004.1| isocitrate dehydrogenase 1 [Anser anser] 705 0.0
sp|Q9XSG3|IDHC_BOVIN Isocitrate dehydrogenase [NADP] cytopl... 705 0.0
ref|XP_001168291.1| PREDICTED: isocitrate dehydrogenase 2 (... 705 0.0
ref|NP_001088022.1| hypothetical protein LOC494713 [Xenopus... 705 0.0
ref|NP_539708.1| isocitrate dehydrogenase [Brucella meliten... 704 0.0
ref|XP_001141655.1| PREDICTED: isocitrate dehydrogenase 1 (... 704 0.0
sp|Q5R9C5|IDHC_PONPY Isocitrate dehydrogenase [NADP] cytopl... 704 0.0
ref|NP_001080321.1| hypothetical protein LOC380013 [Xenopus... 704 0.0
gb|AAH93020.1| Isocitrate dehydrogenase 1 (NADP+), soluble ... 703 0.0
ref|NP_698203.1| isocitrate dehydrogenase [Brucella suis 13... 703 0.0
emb|CAG13105.1| unnamed protein product [Tetraodon nigrovir... 703 0.0
ref|XP_001505172.1| PREDICTED: similar to Isocitrate dehydr... 703 0.0
emb|CAD97653.1| hypothetical protein [Homo sapiens] >gi|117... 703 0.0
sp|O88844|IDHC_MOUSE Isocitrate dehydrogenase [NADP] cytopl... 703 0.0
ref|XP_860821.1| PREDICTED: similar to Isocitrate dehydroge... 702 0.0
ref|NP_034627.3| isocitrate dehydrogenase 1 (NADP+), solubl... 702 0.0
emb|CAH89719.1| hypothetical protein [Pongo abelii] 702 0.0
dbj|BAC39792.1| unnamed protein product [Mus musculus] 701 0.0
dbj|BAC77065.1| NADP-specific isocitrate dehydrogenase [Lup... 701 0.0
emb|CAB66637.1| hypothetical protein [Homo sapiens] >gi|117... 701 0.0
ref|NP_001004799.1| MGC69505 protein [Xenopus tropicalis] >... 701 0.0
dbj|BAE39644.1| unnamed protein product [Mus musculus] 701 0.0
emb|CAG02362.1| unnamed protein product [Tetraodon nigrovir... 701 0.0
gb|AAH88986.1| Isocitrate dehydrogenase 1 (NADP+), soluble ... 701 0.0
emb|CAH91635.1| hypothetical protein [Pongo abelii] 700 0.0
ref|ZP_01885694.1| isocitrate dehydrogenase [Pedobacter sp.... 700 0.0
ref|YP_677841.1| isocitrate dehydrogenase [Cytophaga hutchi... 700 0.0
ref|XP_001168261.1| PREDICTED: isocitrate dehydrogenase 2 (... 699 0.0
ref|ZP_00056387.1| COG0538: Isocitrate dehydrogenases [Magn... 698 0.0
ref|YP_419971.1| isocitrate dehydrogenase [Magnetospirillum... 698 0.0
emb|CAA53300.1| isocitrate dehydrogenase (NADP+) [Solanum t... 698 0.0
gb|AAD02918.1| NADP-dependent isocitrate dehydrogenase [Hom... 698 0.0
pdb|2CMJ|A Chain A, Crystal Structure Of Mouse Cytosolic Is... 698 0.0
ref|XP_001778805.1| predicted protein [Physcomitrella paten... 697 0.0
emb|CAG38553.1| IDH1 [Homo sapiens] 697 0.0
ref|XP_001365492.1| PREDICTED: similar to cytosolic NADP-de... 695 0.0
ref|ZP_02188085.1| Isocitrate dehydrogenase [alpha proteoba... 695 0.0
ref|XP_860853.1| PREDICTED: similar to Isocitrate dehydroge... 695 0.0
ref|XP_001511049.1| PREDICTED: similar to cytosolic NADP-de... 695 0.0
ref|XP_001688948.1| AGAP006660-PA [Anopheles gambiae str. P... 694 0.0
ref|XP_001841910.1| isocitrate dehydrogenase cytoplasmic [C... 694 0.0
ref|YP_001370537.1| isocitrate dehydrogenase, NADP-dependen... 694 0.0
gb|AAB39248.1| NADP-isocitrate dehydrogenase [Eucalyptus gl... 693 0.0
ref|NP_001056381.1| Os05g0573200 [Oryza sativa (japonica cu... 692 0.0
gb|AAC64182.1| NADP-dependent isocitrate dehydrogenase [Gly... 692 0.0
ref|NP_101923.1| isocitrate dehydrogenase [Mesorhizobium lo... 692 0.0
ref|XP_970446.1| PREDICTED: similar to isocitrate dehydroge... 692 0.0
gb|AAC52473.1| isocitrate dehydrogenase 692 0.0
sp|P50217|IDHC_SOLTU Isocitrate dehydrogenase [NADP] (Oxalo... 692 0.0
gb|EEJ98364.1| isocitrate dehydrogenase (NADP) [Thermomonos... 692 0.0
sp|P50218|IDHC_TOBAC Isocitrate dehydrogenase [NADP] (Oxalo... 692 0.0
prf||2211361A isocitrate dehydrogenase 691 0.0
ref|YP_673828.1| isocitrate dehydrogenase [Mesorhizobium sp... 691 0.0
sp|Q40345|IDHP_MEDSA Isocitrate dehydrogenase [NADP], chlor... 691 0.0
ref|XP_001240510.1| isocitrate dehydrogenase NADP, mitochon... 691 0.0
ref|NP_385898.1| isocitrate dehydrogenase [Sinorhizobium me... 690 0.0
gb|EDT29808.1| isocitrate dehydrogenase, NADP-dependent [Ol... 690 0.0
gb|AAA33978.1| NADPH-specific isocitrate dehydrogenase 690 0.0
ref|XP_001650675.1| nadp-specific isocitrate dehydrogenase ... 690 0.0
ref|NP_001043749.1| Os01g0654500 [Oryza sativa (japonica cu... 690 0.0
ref|YP_002826161.1| NADP isocitrate dehydrogenase [Rhizobiu... 689 0.0
ref|ZP_03891012.1| isocitrate dehydrogenase (NADP) [Geoderm... 689 0.0
ref|XP_001698704.1| isocitrate dehydrogenase, NADP-dependen... 689 0.0
pir||S33612 isocitrate dehydrogenase (NADP) (EC 1.1.1.42) -... 689 0.0
ref|YP_425448.1| isocitrate dehydrogenase [Rhodospirillum r... 689 0.0
ref|YP_290624.1| isocitrate dehydrogenase [Thermobifida fus... 689 0.0
ref|YP_001327198.1| isocitrate dehydrogenase [Sinorhizobium... 688 0.0
gb|AAF73472.1|AF268076_1 NADP-dependent isocitrate dehydrog... 688 0.0
ref|XP_001778590.1| predicted protein [Physcomitrella paten... 688 0.0
ref|XP_001633903.1| predicted protein [Nematostella vectens... 688 0.0
ref|XP_968850.1| PREDICTED: similar to CG7176-PC, isoform C... 688 0.0
ref|NP_958907.1| isocitrate dehydrogenase 1 (NADP+), solubl... 687 0.0
ref|NP_421325.1| isocitrate dehydrogenase [Caulobacter cres... 687 0.0
gb|ACO14957.1| Isocitrate dehydrogenase cytoplasmic [Caligu... 687 0.0
ref|YP_001413846.1| isocitrate dehydrogenase, NADP-dependen... 687 0.0
ref|NP_196963.2| isocitrate dehydrogenase, putative / NADP+... 687 0.0
emb|CAQ15240.1| isocitrate dehydrogenase 1 (NADP+), soluble... 687 0.0
emb|CAA65503.1| isocitrate dehydrogenase (NADP+) [Nicotiana... 687 0.0
gb|AAV33246.1| isocitrate dehydrogenase [Toxoplasma gondii] 687 0.0
ref|XP_821599.1| isocitrate dehydrogenase, putative [Trypan... 687 0.0
dbj|BAA34112.1| NADP specific isocitrate dehydrogenase [Dau... 687 0.0
gb|AAT06312.1| isocitrate dehydrogenase [Rhizobium legumino... 687 0.0
ref|YP_001609735.1| NADP-dependent isocitrate dehydrogenase... 686 0.0
ref|ZP_02124492.1| Isocitrate dehydrogenase (NADP(+)) [Meth... 686 0.0
ref|YP_768215.1| isocitrate dehydrogenase [Rhizobium legumi... 686 0.0
ref|ZP_02295934.1| isocitrate dehydrogenase, NADP-dependent... 686 0.0
emb|CAA65504.1| isocitrate dehydrogenase (NADP+) [Nicotiana... 686 0.0
ref|ZP_02166681.1| isocitrate dehydrogenase [Hoeflea photot... 686 0.0
gb|AAD51361.1|AF176669_1 NADP-isocitrate dehydrogenase [Cit... 686 0.0
ref|ZP_02858718.1| isocitrate dehydrogenase, NADP-dependent... 686 0.0
dbj|BAE48792.1| NADP-isocitrate dehydrogenase [Codonopsis l... 686 0.0
dbj|BAA34113.1| NADP specific isocitrate dehydrogenase [Dau... 685 0.0
dbj|BAC77063.1| NADP-specific isocitrate dehydrogenase [Lup... 685 0.0
ref|XP_001176537.1| PREDICTED: similar to Isocitrate dehydr... 685 0.0
ref|YP_706173.1| isocitrate dehydrogenase [Rhodococcus sp. ... 685 0.0
ref|NP_354851.2| isocitrate dehydrogenase [Agrobacterium tu... 685 0.0
gb|AAL11503.1|AF367443_1 NADP-dependent isocitrate dehydrog... 685 0.0
gb|ABA18651.1| cytosolic NADP+-isocitrate dehydrogenase [Po... 685 0.0
ref|XP_312860.4| AGAP003168-PA [Anopheles gambiae str. PEST... 684 0.0
ref|YP_001296741.1| isocitrate dehydrogenase [Flavobacteriu... 684 0.0
emb|CAA73139.1| isocitrate dehydrogenase (NADP+) [Apium gra... 684 0.0
ref|YP_001524781.1| NADP-dependent isocitrate dehydrogenase... 684 0.0
sp|Q06197|IDHC_SOYBN Isocitrate dehydrogenase [NADP] (Oxalo... 684 0.0
ref|YP_872148.1| isocitrate dehydrogenase [Acidothermus cel... 684 0.0
ref|XP_754749.1| isocitrate dehydrogenase Idp1 [Aspergillus... 684 0.0
gb|EDP52872.1| isocitrate dehydrogenase Idp1, putative [Asp... 684 0.0
ref|NP_175836.1| ICDH; isocitrate dehydrogenase (NADP+) [Ar... 683 0.0
ref|ZP_03896321.1| isocitrate dehydrogenase (NADP) [Dyadoba... 683 0.0
ref|YP_001769504.1| isocitrate dehydrogenase, NADP-dependen... 682 0.0
ref|YP_002761841.1| NADP-dependent isocitrate dehydrogenase... 682 0.0
emb|CAG02627.1| unnamed protein product [Tetraodon nigrovir... 682 0.0
ref|ZP_01228834.1| NADP dependent isocitrate dehydrogenase ... 682 0.0
gb|ABK24873.1| unknown [Picea sitchensis] 682 0.0
ref|NP_001040134.1| isocitrate dehydrogenase [Bombyx mori] ... 682 0.0
dbj|BAC77064.1| NADP-specific isocitrate dehydrogenase [Lup... 682 0.0
ref|YP_001685152.1| isocitrate dehydrogenase, NADP-dependen... 681 0.0
gb|AAK76730.1| mitochondrial NADP-dependent isocitrate dehy... 680 0.0
ref|YP_032403.1| isocitrate dehydrogenase [Bartonella quint... 680 0.0
ref|XP_001608101.1| PREDICTED: similar to isocitrate dehydr... 680 0.0
emb|CAD24779.1| isocitrate dehydrogenase [Cucumis sativus] 679 0.0
gb|EAY99113.1| hypothetical protein OsI_020346 [Oryza sativ... 679 0.0
ref|ZP_00952302.1| isocitrate dehydrogenase [Oceanicaulis a... 679 0.0
ref|YP_033790.1| isocitrate dehydrogenase [Bartonella hense... 679 0.0
gb|AAS49171.1| NADP-dependent isocitrate dehydrogenase [Pis... 679 0.0
ref|YP_001419447.1| isocitrate dehydrogenase, NADP-dependen... 679 0.0
ref|XP_001903959.1| unnamed protein product [Podospora anse... 679 0.0
gb|AAR05796.1| NADP+-isocitrate dehydrogenase [Pinus pinaster] 678 0.0
emb|CAB87626.1| isocitrate dehydrogenase-like protein [Arab... 678 0.0
ref|XP_955850.1| hypothetical protein NCU03857 [Neurospora ... 678 0.0
ref|YP_002783489.1| isocitrate dehydrogenase [Rhodococcus o... 678 0.0
ref|YP_117132.1| isocitrate dehydrogenase [Nocardia farcini... 678 0.0
ref|YP_001538953.1| isocitrate dehydrogenase, NADP-dependen... 678 0.0
ref|XP_001226620.1| conserved hypothetical protein [Chaetom... 678 0.0
ref|XP_623673.2| PREDICTED: similar to Isocitrate dehydroge... 678 0.0
emb|CAN72808.1| hypothetical protein [Vitis vinifera] >gi|1... 677 0.0
gb|ABI52605.1| isocitrate dehydrogenase [Gryllus firmus] 677 0.0
ref|ZP_01862723.1| isocitrate dehydrogenase [Erythrobacter ... 677 0.0
emb|CAA63220.1| isocitrate dehydrogenase (NAD+) [Solanum tu... 677 0.0
ref|NP_772387.1| isocitrate dehydrogenase [Bradyrhizobium j... 677 0.0
ref|YP_002765452.1| NADP-dependent isocitrate dehydrogenase... 676 0.0
sp|P79089|IDHP_ASPNG Isocitrate dehydrogenase [NADP], mitoc... 676 0.0
ref|YP_682929.1| isocitrate dehydrogenase [Roseobacter deni... 676 0.0
ref|YP_001832264.1| isocitrate dehydrogenase, NADP-dependen... 676 0.0
ref|NP_001093090.1| NADPH-specific isocitrate dehydrogenase... 676 0.0
ref|XP_001845030.1| isocitrate dehydrogenase [Culex pipiens... 676 0.0
ref|YP_617009.1| isocitrate dehydrogenase [Sphingopyxis ala... 676 0.0
ref|ZP_01303522.1| isocitrate dehydrogenase, NADP-dependent... 676 0.0
ref|YP_001233708.1| isocitrate dehydrogenase [Acidiphilium ... 676 0.0
ref|ZP_03869030.1| isocitrate dehydrogenase (NADP) [Jonesia... 676 0.0
ref|YP_001160602.1| isocitrate dehydrogenase [Salinispora t... 675 0.0
ref|YP_496560.1| isocitrate dehydrogenase [Novosphingobium ... 675 0.0
ref|ZP_01440188.1| Isocitrate/isopropylmalate dehydrogenase... 675 0.0
ref|YP_001709366.1| isocitrate dehydrogenase [Clavibacter m... 675 0.0
ref|ZP_01040029.1| isocitrate dehydrogenase [Erythrobacter ... 675 0.0
ref|YP_062774.1| isocitrate dehydrogenase [Leifsonia xyli s... 675 0.0
ref|ZP_02955422.1| isocitrate dehydrogenase, NADP-dependent... 675 0.0
ref|YP_001223282.1| isocitrate dehydrogenase [Clavibacter m... 674 0.0
ref|ZP_01546031.1| isocitrate dehydrogenase [Stappia aggreg... 674 0.0
ref|YP_989041.1| isocitrate dehydrogenase [Bartonella bacil... 673 0.0
ref|YP_001758392.1| isocitrate dehydrogenase, NADP-dependen... 673 0.0
gb|AAT44354.1| isocitrate dehydrogenase [Crassostrea gigas] 673 0.0
ref|XP_001593497.1| hypothetical protein SS1G_04924 [Sclero... 673 0.0
ref|NP_001053269.1| Os04g0508200 [Oryza sativa (japonica cu... 673 0.0
ref|XP_451683.1| unnamed protein product [Kluyveromyces lac... 673 0.0
gb|AAK76731.1| peroxisomal NADP-dependent isocitrate dehydr... 673 0.0
ref|XP_001462393.1| hypothetical protein GSPATT00027349001 ... 672 0.0
ref|YP_001833636.1| isocitrate dehydrogenase, NADP-dependen... 672 0.0
ref|YP_001108727.1| isocitrate dehydrogenase [Saccharopolys... 672 0.0
gb|EAY58582.1| isocitrate dehydrogenase [NADP] icd1 [Mycoba... 672 0.0
ref|ZP_00954676.1| isocitrate dehydrogenase [Sulfitobacter ... 672 0.0
ref|NP_217856.1| isocitrate dehydrogenase [Mycobacterium tu... 672 0.0
ref|ZP_00964081.1| isocitrate dehydrogenase [Sulfitobacter ... 672 0.0
ref|XP_001454244.1| hypothetical protein GSPATT00020509001 ... 672 0.0
ref|XP_001400371.1| precursor of mitochondrial isocitrate d... 672 0.0
emb|CAO64975.1| unnamed protein product [Vitis vinifera] 672 0.0
ref|YP_458429.1| isocitrate dehydrogenase [Erythrobacter li... 672 0.0
ref|ZP_03819206.1| isocitrate dehydrogenase (NADP) [Actinos... 671 0.0
ref|YP_979491.1| isocitrate dehydrogenase [Mycobacterium bo... 671 0.0
emb|CAE04728.1| OSJNBa0043L24.16 [Oryza sativa (japonica cu... 671 0.0
ref|NP_176768.1| isocitrate dehydrogenase, putative / NADP+... 671 0.0
ref|NP_949171.1| isocitrate dehydrogenase [Rhodopseudomonas... 671 0.0
ref|YP_756242.1| isocitrate dehydrogenase [Maricaulis maris... 670 0.0
ref|YP_001204807.1| isocitrate dehydrogenase [Bradyrhizobiu... 670 0.0
emb|CAD24782.1| isocitrate dehydrogenase [Arabidopsis thali... 670 0.0
gb|AAM13090.1| similar to NADP-specific isocitrate dehydrog... 670 0.0
ref|YP_001849499.1| isocitrate dehydrogenase [NADP] Icd1 [M... 670 0.0
ref|XP_001020930.2| dehydrogenase, isocitrate/isopropylmala... 669 0.0
ref|YP_001363715.1| isocitrate dehydrogenase, NADP-dependen... 669 0.0
emb|CAH67563.1| OSIGBa0101P20.6 [Oryza sativa (indica culti... 669 0.0
gb|AAM65674.1| isocitrate dehydrogenase, putative [Arabidop... 669 0.0
ref|XP_001670101.1| Hypothetical protein CBG21657 [Caenorha... 669 0.0
ref|XP_001384028.1| Isocitrate dehydrogenase [NADP], mitoch... 669 0.0
ref|XP_001528456.1| isocitrate dehydrogenase, mitochondrial... 668 0.0
ref|NP_001042583.1| Os01g0248400 [Oryza sativa (japonica cu... 668 0.0
ref|XP_660603.1| IDHP_ASPNG ISOCITRATE DEHYDROGENASE [NADP]... 668 0.0
ref|YP_487337.1| isocitrate dehydrogenase [Rhodopseudomonas... 667 0.0
ref|YP_001623415.1| isocitrate dehydrogenase (NADP) [Reniba... 667 0.0
ref|ZP_02302766.1| isocitrate dehydrogenase, NADP-dependent... 667 0.0
sp|P50215|IDH_SPHYA Isocitrate dehydrogenase [NADP] (Oxalos... 667 0.0
ref|YP_001169228.1| isocitrate dehydrogenase [Rhodobacter s... 667 0.0
ref|YP_001241304.1| isocitrate dehydrogenase [Bradyrhizobiu... 667 0.0
ref|XP_710919.1| NADP-specific isocitrate dehydrogenase [Ca... 667 0.0
ref|ZP_03922528.1| isocitrate dehydrogenase [Mobiluncus cur... 666 0.0
ref|YP_001260963.1| isocitrate dehydrogenase [Sphingomonas ... 666 0.0
ref|XP_001263574.1| isocitrate dehydrogenase Idp1, putative... 666 0.0
gb|ABL97438.1| isocitrate dehydrogenase [uncultured marine ... 666 0.0
ref|ZP_01046178.1| isocitrate dehydrogenase NADP-dependent ... 666 0.0
ref|XP_390523.1| hypothetical protein FG10347.1 [Gibberella... 666 0.0
ref|XP_001837820.1| hypothetical protein CC1G_11465 [Coprin... 666 0.0
ref|YP_568874.1| isocitrate dehydrogenase [Rhodopseudomonas... 665 0.0
gb|ABO93633.1| isocitrate dehydrogenase 2 [Toxoplasma gondii] 665 0.0
ref|XP_504978.1| hypothetical protein [Yarrowia lipolytica]... 665 0.0
ref|XP_001676039.1| Hypothetical protein CBG17397 [Caenorha... 665 0.0
ref|YP_001601185.1| Isocitrate dehydrogenase [Gluconacetoba... 665 0.0
ref|ZP_01018081.1| isocitrate dehydrogenase [Parvularcula b... 664 0.0
ref|XP_828183.1| isocitrate dehydrogenase [Trypanosoma bruc... 664 0.0
ref|YP_001168561.1| isocitrate dehydrogenase [Rhodobacter s... 664 0.0
ref|XP_001507484.1| PREDICTED: similar to isocitrate dehydr... 664 0.0
ref|XP_459772.1| hypothetical protein DEHA0E11286g [Debaryo... 664 0.0
ref|XP_001818331.1| hypothetical protein [Aspergillus oryza... 664 0.0
ref|YP_759895.1| isocitrate dehydrogenase [Hyphomonas neptu... 664 0.0
ref|YP_001043974.1| isocitrate dehydrogenase [Rhodobacter s... 664 0.0
ref|NP_501665.1| F59B8.2 [Caenorhabditis elegans] >gi|38778... 664 0.0
ref|YP_001042101.1| isocitrate dehydrogenase [Rhodobacter s... 664 0.0
ref|XP_367343.2| hypothetical protein MGG_07268 [Magnaporth... 663 0.0
ref|XP_001878769.1| predicted protein [Laccaria bicolor S23... 663 0.0
ref|ZP_02981592.1| isocitrate dehydrogenase, NADP-dependent... 663 0.0
ref|XP_001270886.1| isocitrate dehydrogenase Idp1, putative... 663 0.0
ref|ZP_03813993.1| isocitrate dehydrogenase (NADP) [Beutenb... 663 0.0
gb|ABF20244.1| mitochondrial isocitrate dehydrogenase [Leis... 663 0.0
gb|ABF20272.1| mitochondrial isocitrate dehydrogenase [Leis... 662 0.0
ref|YP_353519.1| isocitrate dehydrogenase [Rhodobacter spha... 662 0.0
ref|XP_001463680.1| isocitrate dehydrogenase [NADP], mitoch... 662 0.0
ref|YP_317907.1| isocitrate dehydrogenase [Nitrobacter wino... 662 0.0
ref|YP_531457.1| isocitrate dehydrogenase [Rhodopseudomonas... 662 0.0
ref|XP_001457045.1| hypothetical protein GSPATT00022820001 ... 662 0.0
ref|YP_576902.1| isocitrate dehydrogenase [Nitrobacter hamb... 662 0.0
ref|XP_001484278.1| isocitrate dehydrogenase, mitochondrial... 662 0.0
ref|YP_351602.1| isocitrate dehydrogenase [Rhodobacter spha... 662 0.0
ref|ZP_00960755.1| Isocitrate dehydrogenase [Roseovarius nu... 662 0.0
ref|YP_780531.1| isocitrate dehydrogenase [Rhodopseudomonas... 661 0.0
ref|XP_001426548.1| hypothetical protein GSPATT00029781001 ... 661 0.0
ref|ZP_02963068.1| isocitrate dehydrogenase [Bifidobacteriu... 661 0.0
ref|YP_909639.1| isocitrate dehydrogenase [Bifidobacterium ... 661 0.0
ref|ZP_01130474.1| isocitrate dehydrogenase [marine actinob... 660 0.0
ref|ZP_01157336.1| isocitrate dehydrogenase [Oceanicola gra... 660 0.0
ref|XP_780121.1| PREDICTED: similar to cytosolic NADP-depen... 660 0.0
ref|NP_509875.1| C34F6.8 [Caenorhabditis elegans] >gi|38747... 660 0.0
ref|XP_001681361.1| isocitrate dehydrogenase [NADP], mitoch... 660 0.0
ref|ZP_01448513.1| isocitrate dehydrogenase [alpha proteoba... 660 0.0
sp|O13285|IDH1_CANTR Isocitrate dehydrogenase [NADP], mitoc... 659 0.0
ref|NP_962389.1| isocitrate dehydrogenase [Mycobacterium av... 659 0.0
ref|NP_010217.1| Mitochondrial NADP-specific isocitrate deh... 659 0.0
gb|ABD36135.1| isocitrate dehydrogenase precursor [Bombyx m... 659 0.0
ref|ZP_00206729.1| COG0538: Isocitrate dehydrogenases [Bifi... 658 0.0
ref|XP_001527573.1| isocitrate dehydrogenase peroxisomal [L... 658 0.0
ref|NP_729367.1| Isocitrate dehydrogenase CG7176-PD, isofor... 658 0.0
gb|ABF20271.1| mitochondrial isocitrate dehydrogenase [Leis... 658 0.0
ref|ZP_03993927.1| isocitrate dehydrogenase [Mobiluncus mul... 657 0.0
ref|XP_713421.1| cytosolic NADP-specific isocitrate dehydro... 657 0.0
ref|YP_883449.1| isocitrate dehydrogenase [Mycobacterium av... 657 0.0
ref|NP_729366.1| Isocitrate dehydrogenase CG7176-PB, isofor... 657 0.0
ref|XP_001562802.1| isocitrate dehydrogenase [NADP], mitoch... 657 0.0
gb|ABK25438.1| unknown [Picea sitchensis] 657 0.0
ref|NP_696658.1| isocitrate dehydrogenase [Bifidobacterium ... 656 0.0
ref|ZP_01751534.1| isocitrate dehydrogenase [Roseobacter sp... 656 0.0
ref|NP_652044.1| Isocitrate dehydrogenase CG7176-PC, isofor... 656 0.0
ref|NP_984921.1| AER061Cp [Ashbya gossypii ATCC 10895] >gi|... 656 0.0
Sequences not found previously or not previously below threshold:
>ref|XP_536192.2| PREDICTED: similar to isocitrate dehydrogenase 2 (NADP+),
mitochondrial [Canis familiaris]
Length = 517
Score = 719 bits (1857), Expect = 0.0, Method: Composition-based stats.
Identities = 256/409 (62%), Positives = 320/409 (78%), Gaps = 1/409 (0%)
Query: 3 KISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEAAY 62
+I +VE+DGDEMTR+IW+ IKE LI P V+V ++Y+DL + NRD+T D+VT+++A
Sbjct: 109 RIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDVQLKYFDLGLPNRDQTNDQVTIDSAL 168
Query: 63 AIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRLVT 122
A +K+ V VKCATITPDEARV+EF LKKMW+SPNGTIR ILGGTVFREPIIC N+PRLV
Sbjct: 169 ATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVP 228
Query: 123 TWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGGVMMGMY 182
W KP+ IGRHA GDQY ATD VV GTF++ F P +G K ++V+++ GGV MGMY
Sbjct: 229 GWTKPITIGRHAHGDQYKATDFVVDRAGTFKIIFSPKDGSGAKEWEVYNFPGGGVGMGMY 288
Query: 183 NTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKTCG 242
NTD+SI FA SCF++A+ +KWPLY+STKNTILK YDGRFKDIF E+++ Y+T F
Sbjct: 289 NTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFEKHYKTDFDKNK 348
Query: 243 IFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGKTV 302
I+YEHRLIDDMVA ++S GG+VWACKNYDGDVQSD LAQGFGSLG+MTS+L+ PDGKT+
Sbjct: 349 IWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTI 408
Query: 303 EVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLEDVI 362
E EAAHGTVTRHYR++QKG+ TSTNP+ASIFAWTR L HR ++D N L+ F Q LE V
Sbjct: 409 EAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQTLEKVC 468
Query: 363 IATIEAGAMTEDLAICIKGEKNVV-RADYLNTDEFIDAVSQRLKVAMQK 410
+ T+E+GAMT+DLA CI G NV +LNT +F+D + L A+ +
Sbjct: 469 VQTVESGAMTKDLAGCIHGLSNVKLNEHFLNTSDFLDTIKNNLDKALGQ 517
>ref|NP_001026770.1| hypothetical protein LOC431056 [Gallus gallus]
emb|CAG31511.1| hypothetical protein [Gallus gallus]
Length = 452
Score = 719 bits (1856), Expect = 0.0, Method: Composition-based stats.
Identities = 258/409 (63%), Positives = 323/409 (78%), Gaps = 1/409 (0%)
Query: 3 KISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEAAY 62
+I +VE+DGDEMTR+IW IKE LI P V+V ++Y+DL + +RDKT+D+VT+++A
Sbjct: 43 RIKVANPVVEMDGDEMTRIIWAFIKEKLILPNVDVQLKYFDLGLPHRDKTDDQVTIDSAL 102
Query: 63 AIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRLVT 122
A KK+ V VKCATITPDEARV+EF LKKMW+SPNGTIR ILGGTVFREPIIC N+PRLV
Sbjct: 103 ATKKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVP 162
Query: 123 TWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGGVMMGMY 182
W +P+ IGRHA GDQY ATD VV + GTF+M F P +G K ++VF++ GGV MGMY
Sbjct: 163 GWTQPITIGRHAHGDQYKATDFVVNKSGTFKMVFTPKDGSGVKEWEVFNFPGGGVGMGMY 222
Query: 183 NTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKTCG 242
NTD+SI FA SCF++A+ +KWPLY+STKNTILK YDGRFKDIF E++ Y+T+F
Sbjct: 223 NTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTEFDKLK 282
Query: 243 IFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGKTV 302
I+YEHRLIDDMVA ++S GG+VWACKNYDGDVQSD LAQGFGSLG+MTS+L+ PDGKT+
Sbjct: 283 IWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTI 342
Query: 303 EVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLEDVI 362
E EAAHGTVTRHYR++QKG+ TSTNP+ASIFAWTR L HR ++D+N L++F Q LE V
Sbjct: 343 EAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDSNPELIKFAQTLEKVC 402
Query: 363 IATIEAGAMTEDLAICIKGEKNVV-RADYLNTDEFIDAVSQRLKVAMQK 410
+ T+E+G MT+DLA CI G NV ++NT +F+DA+ L A+ K
Sbjct: 403 VETVESGTMTKDLAGCIHGLANVKLNEHFVNTTDFLDAIKNTLDKALGK 451
>ref|NP_786984.1| isocitrate dehydrogenase 2 (NADP+), mitochondrial [Bos taurus]
emb|CAA49207.1| isocitrate dehydrogenase (NADP+) [Bos taurus]
Length = 452
Score = 718 bits (1853), Expect = 0.0, Method: Composition-based stats.
Identities = 256/410 (62%), Positives = 322/410 (78%), Gaps = 1/410 (0%)
Query: 3 KISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEAAY 62
+I +VE+DGDEMTR+IW+ IKE LI P V+V ++Y+DL + NRD+T D+VT+++A
Sbjct: 43 RIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDVQLKYFDLGLPNRDQTNDQVTIDSAL 102
Query: 63 AIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRLVT 122
A +K+ V VKCATITPDEARV+EF LKKMW+SPNGTIR ILGGTVFREPIIC N+PRLV
Sbjct: 103 ATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVP 162
Query: 123 TWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGGVMMGMY 182
W KP+ IGRHA GDQY ATD VV GTF++ F P +G PK ++V+++ +GGV MGMY
Sbjct: 163 GWTKPITIGRHAHGDQYKATDFVVDRAGTFKVVFTPKDGSGPKEWEVYNFPAGGVGMGMY 222
Query: 183 NTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKTCG 242
NTD+SI FA SCF++A+ +KWPLY+STKNTILK YDGRFKDIF +++ Y+T+F
Sbjct: 223 NTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQAIFEKHYKTEFDKHK 282
Query: 243 IFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGKTV 302
I+YEHRLIDDMVA ++S GG+VWACKNYDGDVQSD LAQGFGSLG+MTS+L+ PDGKT+
Sbjct: 283 IWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTI 342
Query: 303 EVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLEDVI 362
E EAAHGTVTRHYR++QKG+ TSTNP+ASIFAWTR L HR ++D N L+ F Q LE V
Sbjct: 343 EAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQTLEKVC 402
Query: 363 IATIEAGAMTEDLAICIKGEKNVV-RADYLNTDEFIDAVSQRLKVAMQKS 411
+ T+E+GAMT+DLA CI G NV +LNT +F+D + L A+ +
Sbjct: 403 VETVESGAMTKDLAGCIHGLSNVKLNEHFLNTSDFLDTIKSNLDRALGQQ 452
>sp|Q04467|IDHP_BOVIN Isocitrate dehydrogenase [NADP], mitochondrial precursor
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) (IDP) (ICD-M)
gb|AAI02510.1| Isocitrate dehydrogenase 2 (NADP+), mitochondrial [Bos taurus]
Length = 452
Score = 718 bits (1853), Expect = 0.0, Method: Composition-based stats.
Identities = 256/410 (62%), Positives = 322/410 (78%), Gaps = 1/410 (0%)
Query: 3 KISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEAAY 62
+I +VE+DGDEMTR+IW+ IKE LI P V+V ++Y+DL + NRD+T D+VT+++A
Sbjct: 43 RIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDVQLKYFDLGLPNRDQTNDQVTIDSAL 102
Query: 63 AIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRLVT 122
A +K+ V VKCATITPDEARV+EF LKKMW+SPNGTIR ILGGTVFREPIIC N+PRLV
Sbjct: 103 ATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVP 162
Query: 123 TWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGGVMMGMY 182
W KP+ IGRHA GDQY ATD VV GTF++ F P +G PK ++V+++ +GGV MGMY
Sbjct: 163 GWTKPITIGRHAHGDQYKATDFVVDRAGTFKVVFTPKDGSGPKEWEVYNFPAGGVGMGMY 222
Query: 183 NTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKTCG 242
NTD+SI FA SCF++A+ +KWPLY+STKNTILK YDGRFKDIF +++ Y+T+F
Sbjct: 223 NTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQAIFEKHYKTEFDKHK 282
Query: 243 IFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGKTV 302
I+YEHRLIDDMVA ++S GG+VWACKNYDGDVQSD LAQGFGSLG+MTS+L+ PDGKT+
Sbjct: 283 IWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTI 342
Query: 303 EVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLEDVI 362
E EAAHGTVTRHYR++QKG+ TSTNP+ASIFAWTR L HR ++D N L+ F Q LE V
Sbjct: 343 EAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQTLEKVC 402
Query: 363 IATIEAGAMTEDLAICIKGEKNVV-RADYLNTDEFIDAVSQRLKVAMQKS 411
+ T+E+GAMT+DLA CI G NV +LNT +F+D + L A+ +
Sbjct: 403 VETVESGAMTKDLAGCIHGLSNVKLNEHFLNTSDFLDTIKSNLDRALGQQ 452
>sp|P54071|IDHP_MOUSE Isocitrate dehydrogenase [NADP], mitochondrial precursor
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) (IDP) (ICD-M)
dbj|BAC40149.1| unnamed protein product [Mus musculus]
gb|AAH60030.1| Isocitrate dehydrogenase 2 (NADP+), mitochondrial [Mus musculus]
dbj|BAE41142.1| unnamed protein product [Mus musculus]
dbj|BAE36505.1| unnamed protein product [Mus musculus]
dbj|BAE26628.1| unnamed protein product [Mus musculus]
gb|EDL07035.1| isocitrate dehydrogenase 2 (NADP+), mitochondrial, isoform CRA_d
[Mus musculus]
Length = 452
Score = 716 bits (1850), Expect = 0.0, Method: Composition-based stats.
Identities = 257/410 (62%), Positives = 320/410 (78%), Gaps = 1/410 (0%)
Query: 3 KISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEAAY 62
+I +VE+DGDEMTR+IW+ IKE LI P V+V ++Y+DL + NRD+T D+VT+++A
Sbjct: 43 RIKVEKPVVEMDGDEMTRIIWQFIKEKLILPHVDVQLKYFDLGLPNRDQTNDQVTIDSAL 102
Query: 63 AIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRLVT 122
A +K+ V VKCATITPDEARV+EF LKKMW+SPNGTIR ILGGTVFREPIIC N+PRLV
Sbjct: 103 ATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVP 162
Query: 123 TWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGGVMMGMY 182
W KP+ IGRHA GDQY ATD VV GTF++ F P +G K ++V+++ +GGV MGMY
Sbjct: 163 GWTKPITIGRHAHGDQYKATDFVVDRAGTFKLVFTPKDGSSAKEWEVYNFPAGGVGMGMY 222
Query: 183 NTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKTCG 242
NTD+SI FA SCF++++ +KWPLYLSTKNTILK YDGRFKDIF E++ Y+T F
Sbjct: 223 NTDESISGFAHSCFQYSIQKKWPLYLSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNK 282
Query: 243 IFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGKTV 302
I+YEHRLIDDMVA ++S GG+VWACKNYDGDVQSD LAQGFGSLG+MTS+L+ PDGKT+
Sbjct: 283 IWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTI 342
Query: 303 EVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLEDVI 362
E EAAHGTVTRHYR++QKG+ TSTNP+ASIFAWTR L HR ++D N L+ F Q LE V
Sbjct: 343 EAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQTLEKVC 402
Query: 363 IATIEAGAMTEDLAICIKGEKNVV-RADYLNTDEFIDAVSQRLKVAMQKS 411
+ T+E+GAMT+DLA CI G NV +LNT +F+D + L A+ K
Sbjct: 403 VQTVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRALGKQ 452
>ref|XP_001369305.1| PREDICTED: hypothetical protein [Monodelphis domestica]
Length = 455
Score = 716 bits (1849), Expect = 0.0, Method: Composition-based stats.
Identities = 256/409 (62%), Positives = 323/409 (78%), Gaps = 1/409 (0%)
Query: 3 KISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEAAY 62
+I +VE+DGDEMTR+IW+ IKE LI P V+V ++Y+DL + +RD+T+D+VT+++A
Sbjct: 46 RIKVDKPVVEMDGDEMTRIIWQFIKEKLILPHVDVQLKYFDLGLPHRDQTDDQVTIDSAL 105
Query: 63 AIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRLVT 122
A +K+ V VKCATITPDEARV+EF LKKMW+SPNGTIR ILGGTVFREPIIC N+PRLV
Sbjct: 106 ATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVP 165
Query: 123 TWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGGVMMGMY 182
W +P+ IGRHA GDQY ATD VV + GTF+M F P +G K ++V+++ +GGV MGMY
Sbjct: 166 GWTRPITIGRHAHGDQYKATDFVVDKAGTFKMVFTPKDGSGAKEWEVYNFPAGGVGMGMY 225
Query: 183 NTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKTCG 242
NTD+SI FA SCF++A+ +KWPLY+STKNTILK YDGRFKDIF E++ Y+T F
Sbjct: 226 NTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNK 285
Query: 243 IFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGKTV 302
I+YEHRLIDDMVA ++S GG+VWACKNYDGDVQSD LAQGFGSLG+MTS+L+ PDGKT+
Sbjct: 286 IWYEHRLIDDMVAQVLKSNGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTI 345
Query: 303 EVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLEDVI 362
E EAAHGTVTRHYR++QKG+ TSTNP+ASIFAWTR L HR ++D N L++F Q LE V
Sbjct: 346 EAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIKFAQTLEKVC 405
Query: 363 IATIEAGAMTEDLAICIKGEKNVV-RADYLNTDEFIDAVSQRLKVAMQK 410
+ T+E+GAMT+DLA CI G NV YLNT +F+D + L A+ +
Sbjct: 406 VQTVESGAMTKDLAGCIHGLSNVKLNEHYLNTGDFLDTIKNNLDKALGQ 454
>ref|NP_766599.1| isocitrate dehydrogenase 2 (NADP+), mitochondrial [Mus musculus]
gb|AAG43538.1|AF212319_1 NADP+-specific isocitrate dehydrogenase [Mus musculus]
Length = 452
Score = 715 bits (1846), Expect = 0.0, Method: Composition-based stats.
Identities = 257/410 (62%), Positives = 320/410 (78%), Gaps = 1/410 (0%)
Query: 3 KISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEAAY 62
+I +VE+DGDEMTR+IW+ IKE LI P V+V ++Y+DL + NRD+T D+VT+++A
Sbjct: 43 RIKVEKPVVEMDGDEMTRIIWQFIKEKLILPHVDVQLKYFDLGLPNRDQTNDQVTIDSAL 102
Query: 63 AIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRLVT 122
A +K+ V VKCATITPDEARV+EF LKKMW+SPNGTIR ILGGTVFREPIIC N+PRLV
Sbjct: 103 ATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVP 162
Query: 123 TWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGGVMMGMY 182
W KP+ IGRHA GDQY ATD VV GTF++ F P +G K ++V+++ +GGV MGMY
Sbjct: 163 GWTKPITIGRHAHGDQYKATDFVVDRAGTFKLVFTPKDGSSAKEWEVYNFPAGGVGMGMY 222
Query: 183 NTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKTCG 242
NTD+SI FA SCF++++ +KWPLYLSTKNTILK YDGRFKDIF E++ Y+T F
Sbjct: 223 NTDESISGFAHSCFQYSIQKKWPLYLSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDRNK 282
Query: 243 IFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGKTV 302
I+YEHRLIDDMVA ++S GG+VWACKNYDGDVQSD LAQGFGSLG+MTS+L+ PDGKT+
Sbjct: 283 IWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTI 342
Query: 303 EVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLEDVI 362
E EAAHGTVTRHYR++QKG+ TSTNP+ASIFAWTR L HR ++D N L+ F Q LE V
Sbjct: 343 EAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQTLEKVC 402
Query: 363 IATIEAGAMTEDLAICIKGEKNVV-RADYLNTDEFIDAVSQRLKVAMQKS 411
+ T+E+GAMT+DLA CI G NV +LNT +F+D + L A+ K
Sbjct: 403 VQTVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRALGKQ 452
>ref|NP_001014183.1| isocitrate dehydrogenase 2 (NADP+), mitochondrial [Rattus
norvegicus]
sp|P56574|IDHP_RAT Isocitrate dehydrogenase [NADP], mitochondrial precursor
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) (IDP) (ICD-M)
gb|AAH76398.1| Similar to NADP+-specific isocitrate dehydrogenase [Rattus
norvegicus]
gb|EDM08608.1| similar to NADP+-specific isocitrate dehydrogenase, isoform CRA_b
[Rattus norvegicus]
Length = 452
Score = 714 bits (1844), Expect = 0.0, Method: Composition-based stats.
Identities = 255/410 (62%), Positives = 319/410 (77%), Gaps = 1/410 (0%)
Query: 3 KISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEAAY 62
+I +VE+DGDEMTR+IW+ IKE LI P V+V ++Y+DL + NRD+T D+VT+++A
Sbjct: 43 RIKVEKPVVEMDGDEMTRIIWQFIKEKLILPHVDVQLKYFDLGLPNRDQTNDQVTIDSAL 102
Query: 63 AIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRLVT 122
A +K+ V VKCATITPDEARV+EF LKKMW+SPNGTIR ILGGTVFREPIIC N+PRLV
Sbjct: 103 ATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVP 162
Query: 123 TWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGGVMMGMY 182
W KP+ IGRHA GDQY ATD VV G F++ F P +G K ++V+++ +GGV MGMY
Sbjct: 163 GWTKPITIGRHAHGDQYKATDFVVDRAGMFKLVFTPKDGSGAKEWEVYNFPAGGVGMGMY 222
Query: 183 NTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKTCG 242
NTD+SI FA SCF++++ +KWPLYLSTKNTI+K YDGRFKDIF E++ Y+T F
Sbjct: 223 NTDESISGFAHSCFQYSIQKKWPLYLSTKNTIMKAYDGRFKDIFQEIFDKHYKTDFDKNK 282
Query: 243 IFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGKTV 302
I+YEHRLIDDMVA ++S GG+VWACKNYDGDVQSD LAQGFGSLG+MTS+L+ PDGKT+
Sbjct: 283 IWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTI 342
Query: 303 EVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLEDVI 362
E EAAHGTVTRHYR++QKG+ TSTNP+ASIFAWTR L HR ++D N L+ F Q LE V
Sbjct: 343 EAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQTLEKVC 402
Query: 363 IATIEAGAMTEDLAICIKGEKNVV-RADYLNTDEFIDAVSQRLKVAMQKS 411
+ T+E+GAMT+DLA CI G NV +LNT +F+D + L A+ K
Sbjct: 403 VQTVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRALGKQ 452
>ref|XP_510589.2| PREDICTED: isocitrate dehydrogenase 2 (NADP+), mitochondrial
isoform 4 [Pan troglodytes]
Length = 452
Score = 714 bits (1843), Expect = 0.0, Method: Composition-based stats.
Identities = 255/410 (62%), Positives = 320/410 (78%), Gaps = 1/410 (0%)
Query: 3 KISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEAAY 62
+I +VE+DGDEMTR+IW+ IKE LI P V++ ++Y+DL + NRD+T+D+VT+++A
Sbjct: 43 RIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSAL 102
Query: 63 AIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRLVT 122
A +K+ V VKCATITPDEARV+EF LKKMW+SPNGTIR ILGGTVFREPIIC N+PRLV
Sbjct: 103 ATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVP 162
Query: 123 TWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGGVMMGMY 182
W KP+ IGRHA GDQY ATD V GTF+M F P +G K ++V+++ +GGV MGMY
Sbjct: 163 GWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMY 222
Query: 183 NTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKTCG 242
NTD+SI FA SCF++A+ +KWPLY+STKNTILK YDGRFKDIF E++ Y+T F
Sbjct: 223 NTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNK 282
Query: 243 IFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGKTV 302
I+YEHRLIDDMVA ++S GG+VWACKNYDGDVQSD LAQGFGSLG+MTS+L+ PDGKT+
Sbjct: 283 IWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTI 342
Query: 303 EVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLEDVI 362
E EAAHGTVTRHYR++QKG+ TSTNP+ASIFAWTR L HR ++D N L+ F Q LE V
Sbjct: 343 EAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQTLEKVC 402
Query: 363 IATIEAGAMTEDLAICIKGEKNVV-RADYLNTDEFIDAVSQRLKVAMQKS 411
+ T+E+GAMT+DLA CI G NV +LNT +F+D + L A+ +
Sbjct: 403 VETVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRALGRQ 452
>ref|XP_001095686.1| PREDICTED: isocitrate dehydrogenase 2 (NADP+), mitochondrial
[Macaca mulatta]
sp|Q4R502|IDHP_MACFA Isocitrate dehydrogenase [NADP], mitochondrial precursor
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) (IDP) (ICD-M)
dbj|BAE01823.1| unnamed protein product [Macaca fascicularis]
Length = 452
Score = 713 bits (1842), Expect = 0.0, Method: Composition-based stats.
Identities = 255/410 (62%), Positives = 320/410 (78%), Gaps = 1/410 (0%)
Query: 3 KISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEAAY 62
+I +VE+DGDEMTR+IW+ IKE LI P V++ ++Y+DL + NRD+T+D+VT+++A
Sbjct: 43 RIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSAL 102
Query: 63 AIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRLVT 122
A +K+ V VKCATITPDEARV+EF LKKMW+SPNGTIR ILGGTVFREPIIC N+PRLV
Sbjct: 103 ATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVP 162
Query: 123 TWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGGVMMGMY 182
W KP+ IGRHA GDQY ATD V GTF+M F P +G K ++V+++ +GGV MGMY
Sbjct: 163 GWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMY 222
Query: 183 NTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKTCG 242
NTD+SI FA SCF++A+ +KWPLY+STKNTILK YDGRFKDIF E++ Y+T F
Sbjct: 223 NTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNK 282
Query: 243 IFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGKTV 302
I+YEHRLIDDMVA ++S GG+VWACKNYDGDVQSD LAQGFGSLG+MTS+L+ PDGKT+
Sbjct: 283 IWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTI 342
Query: 303 EVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLEDVI 362
E EAAHGTVTRHYR++QKG+ TSTNP+ASIFAWTR L HR ++D N L+ F Q LE V
Sbjct: 343 EAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQTLEKVC 402
Query: 363 IATIEAGAMTEDLAICIKGEKNVV-RADYLNTDEFIDAVSQRLKVAMQKS 411
+ T+E+GAMT+DLA CI G NV +LNT +F+D + L A+ +
Sbjct: 403 VETVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRALGRQ 452
>gb|ACO14046.1| Isocitrate dehydrogenase, mitochondrial precursor [Esox lucius]
Length = 451
Score = 713 bits (1841), Expect = 0.0, Method: Composition-based stats.
Identities = 253/409 (61%), Positives = 321/409 (78%), Gaps = 1/409 (0%)
Query: 3 KISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEAAY 62
+I + +VE+DGDEMTR+IW+ IKE LI V+V ++YYDL + RD+T D+VT+++A
Sbjct: 43 RIKVSQPVVEMDGDEMTRIIWEFIKEKLILSNVDVELKYYDLGLPYRDQTNDQVTIDSAL 102
Query: 63 AIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRLVT 122
A +K+ V VKCATITPDEARV+EF LKKMW+SPNGTIR ILGGTVFREPIIC N+PRLV
Sbjct: 103 ATQKYHVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVP 162
Query: 123 TWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGGVMMGMY 182
W +P+ IGRHAFGDQY ATD VV +PGTF+M F P +G + + + V+++ GG MGMY
Sbjct: 163 GWTQPITIGRHAFGDQYRATDFVVNQPGTFKMVFSPTDGSKGQEWGVYNFPGGGCGMGMY 222
Query: 183 NTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKTCG 242
NTD+SI FA SCF++A+ +KWPLYLSTKNTILK YDGRFKDIF E+++A Y+ +F
Sbjct: 223 NTDESISGFAHSCFQYAIGKKWPLYLSTKNTILKAYDGRFKDIFEEIFQANYKPEFDKLK 282
Query: 243 IFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGKTV 302
I+YEHRLIDDMVA ++S+G +VWACKNYDGDVQSD LAQGFGSLG+MTS+L+ PDGKT+
Sbjct: 283 IWYEHRLIDDMVAQVLKSDGAFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTI 342
Query: 303 EVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLEDVI 362
E EAAHGTVTRHYR++QKG TSTNP+ASIFAWTR L HR ++D N L++F LE V
Sbjct: 343 EAEAAHGTVTRHYREHQKGNPTSTNPIASIFAWTRGLEHRGKLDGNPDLIKFALTLERVC 402
Query: 363 IATIEAGAMTEDLAICIKGEKNVV-RADYLNTDEFIDAVSQRLKVAMQK 410
+ T+E+G MT+DLA CI G Y+NT++F+DA+ + L A+ K
Sbjct: 403 VETVESGVMTKDLAGCIHGLSKCKLNEHYVNTEDFLDAIKKNLDKALGK 451
>gb|ABE98244.1| mitochondrial isocitrate dehydrogenase 2-like [Oreochromis
mossambicus]
Length = 452
Score = 713 bits (1840), Expect = 0.0, Method: Composition-based stats.
Identities = 256/409 (62%), Positives = 323/409 (78%), Gaps = 1/409 (0%)
Query: 3 KISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEAAY 62
+I +VE+DGDEMTR+IW+ IKE LI V+V ++Y+DL + RD+T+D+VT+++A
Sbjct: 44 RIKVANPVVEMDGDEMTRIIWEFIKEKLILTNVDVELKYFDLGLPYRDQTDDQVTIDSAL 103
Query: 63 AIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRLVT 122
A KK+ V VKCATITPDEARV+EF LKKMW+SPNGTIR ILGGTVFREPIIC N+PRLV
Sbjct: 104 ATKKYSVAVKCATITPDEARVEEFGLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVP 163
Query: 123 TWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGGVMMGMY 182
W +P+ IGRHAFGDQY ATD VV +PG F++ F PA+G K ++VFD+ +GG MGMY
Sbjct: 164 GWTQPITIGRHAFGDQYRATDFVVDQPGKFKIVFSPADGSTSKEWEVFDFPAGGCGMGMY 223
Query: 183 NTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKTCG 242
NTD+SI FA SCF++A+ +KWPLY+STKNTILK YDGRFKDIF ++++ Y+ +F
Sbjct: 224 NTDESITGFAHSCFQYAIGKKWPLYMSTKNTILKAYDGRFKDIFQDIFEKNYKPEFDKLK 283
Query: 243 IFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGKTV 302
I+YEHRLIDDMVA ++S G +VWACKNYDGDVQSD LAQGFGSLG+MTS+L+ PDGKT+
Sbjct: 284 IWYEHRLIDDMVAQVLKSSGAFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTI 343
Query: 303 EVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLEDVI 362
E EAAHGTVTRHYR++QKG+ TSTNP+ASIFAWTR L HR ++D N L++F Q LE V
Sbjct: 344 EAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNPDLIKFAQTLEQVC 403
Query: 363 IATIEAGAMTEDLAICIKGEKNVV-RADYLNTDEFIDAVSQRLKVAMQK 410
+AT+E+G MT+DLA CI G NV Y+NT +F+DA+ L A+ K
Sbjct: 404 VATVESGTMTKDLAGCIHGLSNVKLNEHYVNTTDFLDAIKTNLDKALGK 452
>ref|NP_002159.2| isocitrate dehydrogenase 2 (NADP+), mitochondrial precursor [Homo
sapiens]
sp|P48735|IDHP_HUMAN Isocitrate dehydrogenase [NADP], mitochondrial precursor
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) (IDP) (ICD-M)
gb|AAH09244.1| Isocitrate dehydrogenase 2 (NADP+), mitochondrial [Homo sapiens]
gb|AAH71828.1| Isocitrate dehydrogenase 2 (NADP+), mitochondrial [Homo sapiens]
gb|EAX02082.1| isocitrate dehydrogenase 2 (NADP+), mitochondrial, isoform CRA_a
[Homo sapiens]
gb|ABM83743.1| isocitrate dehydrogenase 2 (NADP+), mitochondrial [synthetic
construct]
gb|ABM87062.1| isocitrate dehydrogenase 2 (NADP+), mitochondrial [synthetic
construct]
Length = 452
Score = 712 bits (1839), Expect = 0.0, Method: Composition-based stats.
Identities = 255/410 (62%), Positives = 320/410 (78%), Gaps = 1/410 (0%)
Query: 3 KISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEAAY 62
+I +VE+DGDEMTR+IW+ IKE LI P V++ ++Y+DL + NRD+T+D+VT+++A
Sbjct: 43 RIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSAL 102
Query: 63 AIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRLVT 122
A +K+ V VKCATITPDEARV+EF LKKMW+SPNGTIR ILGGTVFREPIIC N+PRLV
Sbjct: 103 ATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVP 162
Query: 123 TWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGGVMMGMY 182
W KP+ IGRHA GDQY ATD V GTF+M F P +G K ++V+++ +GGV MGMY
Sbjct: 163 GWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMY 222
Query: 183 NTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKTCG 242
NTD+SI FA SCF++A+ +KWPLY+STKNTILK YDGRFKDIF E++ Y+T F
Sbjct: 223 NTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNK 282
Query: 243 IFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGKTV 302
I+YEHRLIDDMVA ++S GG+VWACKNYDGDVQSD LAQGFGSLG+MTS+L+ PDGKT+
Sbjct: 283 IWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTI 342
Query: 303 EVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLEDVI 362
E EAAHGTVTRHYR++QKG+ TSTNP+ASIFAWTR L HR ++D N L+ F Q LE V
Sbjct: 343 EAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQMLEKVC 402
Query: 363 IATIEAGAMTEDLAICIKGEKNVV-RADYLNTDEFIDAVSQRLKVAMQKS 411
+ T+E+GAMT+DLA CI G NV +LNT +F+D + L A+ +
Sbjct: 403 VETVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRALGRQ 452
>ref|NP_955858.1| isocitrate dehydrogenase 2 (NADP+), mitochondrial [Danio rerio]
gb|AAH48041.1| Isocitrate dehydrogenase 2 (NADP+), mitochondrial [Danio rerio]
gb|AAH63967.1| Isocitrate dehydrogenase 2 (NADP+), mitochondrial [Danio rerio]
Length = 449
Score = 712 bits (1839), Expect = 0.0, Method: Composition-based stats.
Identities = 255/409 (62%), Positives = 321/409 (78%), Gaps = 1/409 (0%)
Query: 3 KISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEAAY 62
+I +VE+DGDEMTR+IW+ IKE LI VNV ++YYDL + RD+T+D+VT+++A
Sbjct: 41 RIQVAQPVVEMDGDEMTRIIWEFIKEKLILTNVNVDLKYYDLGLPYRDQTDDQVTIDSAI 100
Query: 63 AIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRLVT 122
A KK+ V VKCATITPDEARV+EF LKKMW+SPNGTIR ILGGTVFREPIIC N+PRLV
Sbjct: 101 ATKKYNVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVP 160
Query: 123 TWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGGVMMGMY 182
W + + IGRHAFGDQY ATD VV +PG F+M F PA+G + K ++V+D+ GG MGMY
Sbjct: 161 GWTQAITIGRHAFGDQYKATDFVVNQPGKFKMVFTPADGSKNKEWEVYDFPGGGCGMGMY 220
Query: 183 NTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKTCG 242
NTD+SI FA SCF++A+ +KWPLY+STKNTILK YDGRFKDIF ++++ Y+ +F
Sbjct: 221 NTDESITGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQDIFEKNYKPEFDKLK 280
Query: 243 IFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGKTV 302
I+YEHRLIDDMVA ++S G +VWACKNYDGDVQSD LAQGFGSLG+MTS+L+ PDGKT+
Sbjct: 281 IWYEHRLIDDMVAQVLKSSGAFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTI 340
Query: 303 EVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLEDVI 362
E EAAHGTVTRHYR++QKG+ TSTNP+ASIFAWTR L HR ++D N L++F+Q LE V
Sbjct: 341 EAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNPDLIKFSQTLERVC 400
Query: 363 IATIEAGAMTEDLAICIKGEKNVV-RADYLNTDEFIDAVSQRLKVAMQK 410
+ T+E+G MT+DLA CI G N Y+NT +F+DA+ L A+ K
Sbjct: 401 VETVESGVMTKDLAGCIHGLANCKLNEHYVNTTDFLDAIKTNLDKALGK 449
>pdb|1LWD|A Chain A, Crystal Structure Of Nadp-Dependent Isocitrate
Dehydrogenase From Porcine Heart Mitochondria
pdb|1LWD|B Chain B, Crystal Structure Of Nadp-Dependent Isocitrate
Dehydrogenase From Porcine Heart Mitochondria
Length = 413
Score = 712 bits (1839), Expect = 0.0, Method: Composition-based stats.
Identities = 256/411 (62%), Positives = 321/411 (78%), Gaps = 1/411 (0%)
Query: 2 NKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEAA 61
+I +VE+DGDEMTR+IW+ IKE LI P V+V ++Y+DL + NRD+T D+VT+++A
Sbjct: 3 QRIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDVQLKYFDLGLPNRDQTNDQVTIDSA 62
Query: 62 YAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRLV 121
A +K+ V VKCATITPDEARV+EF LKKMW+SPNGTIR ILGGTVFREPIIC N+PRLV
Sbjct: 63 LATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLV 122
Query: 122 TTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGGVMMGM 181
W KP+ IGRHA GDQY ATD VV GTF++ F P +G K ++V+++ +GGV MGM
Sbjct: 123 PGWTKPITIGRHAHGDQYKATDFVVDRAGTFKIVFTPKDGSSAKQWEVYNFPAGGVGMGM 182
Query: 182 YNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKTC 241
YNTD+SI FA SCF++A+ +KWPLY+STKNTILK YDGRFKDIF E+++ Y+T F
Sbjct: 183 YNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFEKHYKTDFDKY 242
Query: 242 GIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGKT 301
I+YEHRLIDDMVA ++S GG+VWACKNYDGDVQSD LAQGFGSLG+MTS+L+ PDGKT
Sbjct: 243 KIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKT 302
Query: 302 VEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLEDV 361
+E EAAHGTVTRHYR++QKG+ TSTNP+ASIFAWTR L HR ++D N L+ F Q LE V
Sbjct: 303 IEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQTLEKV 362
Query: 362 IIATIEAGAMTEDLAICIKGEKNVV-RADYLNTDEFIDAVSQRLKVAMQKS 411
+ T+E+GAMT+DLA CI G NV +LNT +F+D + L A+ +
Sbjct: 363 CVETVESGAMTKDLAGCIHGLSNVKLNEHFLNTSDFLDTIKSNLDRALGRQ 413
>sp|P33198|IDHP_PIG Isocitrate dehydrogenase [NADP], mitochondrial precursor
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) (IDP) (ICD-M)
gb|AAA31089.1| NADPH-specific isocitrate dehydrogenase
Length = 421
Score = 712 bits (1838), Expect = 0.0, Method: Composition-based stats.
Identities = 256/411 (62%), Positives = 321/411 (78%), Gaps = 1/411 (0%)
Query: 2 NKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEAA 61
+I +VE+DGDEMTR+IW+ IKE LI P V+V ++Y+DL + NRD+T D+VT+++A
Sbjct: 11 QRIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDVQLKYFDLGLPNRDQTNDQVTIDSA 70
Query: 62 YAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRLV 121
A +K+ V VKCATITPDEARV+EF LKKMW+SPNGTIR ILGGTVFREPIIC N+PRLV
Sbjct: 71 LATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLV 130
Query: 122 TTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGGVMMGM 181
W KP+ IGRHA GDQY ATD VV GTF++ F P +G K ++V+++ +GGV MGM
Sbjct: 131 PGWTKPITIGRHAHGDQYKATDFVVDRAGTFKIVFTPKDGSSAKQWEVYNFPAGGVGMGM 190
Query: 182 YNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKTC 241
YNTD+SI FA SCF++A+ +KWPLY+STKNTILK YDGRFKDIF E+++ Y+T F
Sbjct: 191 YNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFEKHYKTDFDKY 250
Query: 242 GIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGKT 301
I+YEHRLIDDMVA ++S GG+VWACKNYDGDVQSD LAQGFGSLG+MTS+L+ PDGKT
Sbjct: 251 KIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKT 310
Query: 302 VEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLEDV 361
+E EAAHGTVTRHYR++QKG+ TSTNP+ASIFAWTR L HR ++D N L+ F Q LE V
Sbjct: 311 IEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQTLEKV 370
Query: 362 IIATIEAGAMTEDLAICIKGEKNVV-RADYLNTDEFIDAVSQRLKVAMQKS 411
+ T+E+GAMT+DLA CI G NV +LNT +F+D + L A+ +
Sbjct: 371 CVETVESGAMTKDLAGCIHGLSNVKLNEHFLNTSDFLDTIKSNLDRALGRQ 421
>emb|CAA49208.1| isocitrate dehydrogenase (NADP+) [Homo sapiens]
Length = 452
Score = 711 bits (1837), Expect = 0.0, Method: Composition-based stats.
Identities = 255/410 (62%), Positives = 320/410 (78%), Gaps = 1/410 (0%)
Query: 3 KISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEAAY 62
+I +VE+DGDEMTR+IW+ IKE LI P V++ ++Y+DL + NRD+T+D+VT+++A
Sbjct: 43 RIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSAL 102
Query: 63 AIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRLVT 122
A +K+ V VKCATITPDEARV+EF LKKMW+SPNGTIR ILGGTVFREPIIC N+PRLV
Sbjct: 103 ATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVP 162
Query: 123 TWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGGVMMGMY 182
W KP+ IGRHA GDQY ATD V GTF+M F P +G K ++V+++ +GGV MGMY
Sbjct: 163 GWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMY 222
Query: 183 NTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKTCG 242
NTD+SI FA SCF++A+ +KWPLY+STKNTILK YDGRFKDIF E++ Y+T F
Sbjct: 223 NTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNK 282
Query: 243 IFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGKTV 302
I+YEHRLIDDMVA ++S GG+VWACKNYDGDVQSD LAQGFGSLG+MTS+L+ PDGKT+
Sbjct: 283 IWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTI 342
Query: 303 EVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLEDVI 362
E EAAHGTVTRHYR++QKG+ TSTNP+ASIFAWTR L HR ++D N L+ F Q LE V
Sbjct: 343 EAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQMLEKVC 402
Query: 363 IATIEAGAMTEDLAICIKGEKNVV-RADYLNTDEFIDAVSQRLKVAMQKS 411
+ T+E+GAMT+DLA CI G NV +LNT +F+D + L A+ +
Sbjct: 403 VETVESGAMTKDLAGCIHGLSNVKLNEHFLNTMDFLDTIKSNLDRALGRQ 452
>dbj|BAD96636.1| isocitrate dehydrogenase 2 (NADP+), mitochondrial precursor variant
[Homo sapiens]
Length = 452
Score = 711 bits (1836), Expect = 0.0, Method: Composition-based stats.
Identities = 256/410 (62%), Positives = 320/410 (78%), Gaps = 1/410 (0%)
Query: 3 KISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEAAY 62
+I +VE+DGDEMTR+IW+ IKE LI P V++ ++Y+DL + NRD+T+D+VT+++A
Sbjct: 43 RIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSAL 102
Query: 63 AIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRLVT 122
A +K+ V VKCATITPDEARV+EF LKKMW+SPNGTIR ILGGTVFREPIIC N+PRLV
Sbjct: 103 ATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVP 162
Query: 123 TWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGGVMMGMY 182
W KP+ IGRHA GDQY ATD V GTF+M F P +G K ++V+++ +GGV MGMY
Sbjct: 163 GWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMY 222
Query: 183 NTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKTCG 242
NTD+SI FA SCF++A+ +KWPLY+STKNTILK YDGRFKDIF E++ YET F
Sbjct: 223 NTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYETDFDKNK 282
Query: 243 IFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGKTV 302
I+YEHRLIDDMVA ++S GG+VWACKNYDGDVQSD LAQGFGSLG+MTS+L+ PDGKT+
Sbjct: 283 IWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTI 342
Query: 303 EVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLEDVI 362
E EAAHGTVTRHYR++QKG+ TSTNP+ASIFAWTR L HR ++D N L+ F Q LE V
Sbjct: 343 EAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQMLEKVC 402
Query: 363 IATIEAGAMTEDLAICIKGEKNVV-RADYLNTDEFIDAVSQRLKVAMQKS 411
+ T+E+GAMT+DLA CI G NV +LNT +F+D + L A+ +
Sbjct: 403 VETVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRALGRQ 452
>ref|XP_001168316.1| PREDICTED: isocitrate dehydrogenase 2 (NADP+), mitochondrial
isoform 3 [Pan troglodytes]
Length = 415
Score = 709 bits (1832), Expect = 0.0, Method: Composition-based stats.
Identities = 255/410 (62%), Positives = 320/410 (78%), Gaps = 1/410 (0%)
Query: 3 KISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEAAY 62
+I +VE+DGDEMTR+IW+ IKE LI P V++ ++Y+DL + NRD+T+D+VT+++A
Sbjct: 6 RIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSAL 65
Query: 63 AIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRLVT 122
A +K+ V VKCATITPDEARV+EF LKKMW+SPNGTIR ILGGTVFREPIIC N+PRLV
Sbjct: 66 ATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVP 125
Query: 123 TWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGGVMMGMY 182
W KP+ IGRHA GDQY ATD V GTF+M F P +G K ++V+++ +GGV MGMY
Sbjct: 126 GWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMY 185
Query: 183 NTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKTCG 242
NTD+SI FA SCF++A+ +KWPLY+STKNTILK YDGRFKDIF E++ Y+T F
Sbjct: 186 NTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNK 245
Query: 243 IFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGKTV 302
I+YEHRLIDDMVA ++S GG+VWACKNYDGDVQSD LAQGFGSLG+MTS+L+ PDGKT+
Sbjct: 246 IWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTI 305
Query: 303 EVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLEDVI 362
E EAAHGTVTRHYR++QKG+ TSTNP+ASIFAWTR L HR ++D N L+ F Q LE V
Sbjct: 306 EAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQTLEKVC 365
Query: 363 IATIEAGAMTEDLAICIKGEKNVV-RADYLNTDEFIDAVSQRLKVAMQKS 411
+ T+E+GAMT+DLA CI G NV +LNT +F+D + L A+ +
Sbjct: 366 VETVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRALGRQ 415
>gb|EAX02083.1| isocitrate dehydrogenase 2 (NADP+), mitochondrial, isoform CRA_b
[Homo sapiens]
Length = 422
Score = 709 bits (1831), Expect = 0.0, Method: Composition-based stats.
Identities = 255/410 (62%), Positives = 320/410 (78%), Gaps = 1/410 (0%)
Query: 3 KISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEAAY 62
+I +VE+DGDEMTR+IW+ IKE LI P V++ ++Y+DL + NRD+T+D+VT+++A
Sbjct: 13 RIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSAL 72
Query: 63 AIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRLVT 122
A +K+ V VKCATITPDEARV+EF LKKMW+SPNGTIR ILGGTVFREPIIC N+PRLV
Sbjct: 73 ATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVP 132
Query: 123 TWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGGVMMGMY 182
W KP+ IGRHA GDQY ATD V GTF+M F P +G K ++V+++ +GGV MGMY
Sbjct: 133 GWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMY 192
Query: 183 NTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKTCG 242
NTD+SI FA SCF++A+ +KWPLY+STKNTILK YDGRFKDIF E++ Y+T F
Sbjct: 193 NTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNK 252
Query: 243 IFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGKTV 302
I+YEHRLIDDMVA ++S GG+VWACKNYDGDVQSD LAQGFGSLG+MTS+L+ PDGKT+
Sbjct: 253 IWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTI 312
Query: 303 EVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLEDVI 362
E EAAHGTVTRHYR++QKG+ TSTNP+ASIFAWTR L HR ++D N L+ F Q LE V
Sbjct: 313 EAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQMLEKVC 372
Query: 363 IATIEAGAMTEDLAICIKGEKNVV-RADYLNTDEFIDAVSQRLKVAMQKS 411
+ T+E+GAMT+DLA CI G NV +LNT +F+D + L A+ +
Sbjct: 373 VETVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRALGRQ 422
>ref|NP_970434.1| isocitrate dehydrogenase [Bdellovibrio bacteriovorus HD100]
emb|CAE81088.1| isocitrate dehydrogenase (NADP) [Bdellovibrio bacteriovorus HD100]
Length = 409
Score = 708 bits (1829), Expect = 0.0, Method: Composition-based stats.
Identities = 266/408 (65%), Positives = 321/408 (78%), Gaps = 1/408 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M KI +VELDGDEMTR+IWK IK+ LI P++++ I+YYDL ME+RD T D+VTV+A
Sbjct: 1 MKKIKVANPVVELDGDEMTRIIWKFIKQQLILPYLDIDIKYYDLGMEHRDATNDQVTVDA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIKK+ VG+KCATITPDEARVKEFNLK+MW+SPNGTIR IL GTVFREPIIC NVPRL
Sbjct: 61 AEAIKKYNVGIKCATITPDEARVKEFNLKQMWKSPNGTIRNILDGTVFREPIICKNVPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGGVMMG 180
V W P+ IGRHAFGDQY ATD V K G + F P NGGE ++V+++K GV +
Sbjct: 121 VPNWTAPICIGRHAFGDQYRATDFVTKGKGKLTVTFQPENGGETITHEVYNFKGDGVALT 180
Query: 181 MYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKT 240
MYNTD+SI FARSCF AL +KWPLYLSTKNTILK YDGRFKDIF E+Y+ ++ KF
Sbjct: 181 MYNTDESITGFARSCFNQALTKKWPLYLSTKNTILKKYDGRFKDIFEEIYQKEFKAKFDA 240
Query: 241 CGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGK 300
GI YEHRLIDDMVA ++ G +VWACKNYDGDVQSD++AQGFGSLG+MTS+L+TPDGK
Sbjct: 241 AGITYEHRLIDDMVASALKWNGNFVWACKNYDGDVQSDTVAQGFGSLGLMTSVLVTPDGK 300
Query: 301 TVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLED 360
T+E EAAHGTVTRHYR +Q+GK TSTNP+ASIFAWTR L HR +DNN L++F Q LE
Sbjct: 301 TMESEAAHGTVTRHYRQHQQGKPTSTNPIASIFAWTRGLEHRGNLDNNQELVKFAQTLEK 360
Query: 361 VIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAM 408
V + T+EAG MT+DLA+CI G+K V Y+NT+ F+ + + LK A+
Sbjct: 361 VCVETVEAGFMTKDLAVCIYGDK-VPADKYMNTEPFLAKLDENLKKAL 407
>ref|XP_001107627.1| PREDICTED: isocitrate dehydrogenase 1 (NADP+), soluble isoform 1
[Macaca mulatta]
ref|XP_001107810.1| PREDICTED: isocitrate dehydrogenase 1 (NADP+), soluble isoform 2
[Macaca mulatta]
ref|XP_001107875.1| PREDICTED: isocitrate dehydrogenase 1 (NADP+), soluble isoform 3
[Macaca mulatta]
ref|XP_001107934.1| PREDICTED: isocitrate dehydrogenase 1 (NADP+), soluble isoform 4
[Macaca mulatta]
ref|XP_001107992.1| PREDICTED: isocitrate dehydrogenase 1 (NADP+), soluble isoform 5
[Macaca mulatta]
Length = 414
Score = 708 bits (1828), Expect = 0.0, Method: Composition-based stats.
Identities = 273/414 (65%), Positives = 333/414 (80%), Gaps = 1/414 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M+K + G +VEL GDEMTR+IW+ IKE LIFP+V + ++ YDL +ENRD T D+VT +A
Sbjct: 1 MSKKISGGSVVELQGDEMTRIIWELIKEKLIFPYVELDLQSYDLGIENRDATNDQVTKDA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIKK+ VGVKCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 61 AEAIKKYNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYK-SGGVMM 179
V+ W KP++IGRHA+GDQY ATD VV PG E+ + P++G + Y V +++ GGV M
Sbjct: 121 VSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAM 180
Query: 180 GMYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFK 239
GMYN D SI DFA S F+ AL++ WPLYLSTKNTILK YDGRFKDIF E+Y Y+++F+
Sbjct: 181 GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE 240
Query: 240 TCGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDG 299
I+YEHRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDG
Sbjct: 241 AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG 300
Query: 300 KTVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLE 359
KTVE EAAHGTVTRHYR YQKG+ETSTNP+ASIFAWTR LAHRA++DNN L F LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALE 360
Query: 360 DVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
+V I TIEAG MT+DLA CIKG NV R+DYLNT EF+D + + LK+ + ++K+
Sbjct: 361 EVCIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL 414
>ref|NP_851355.2| isocitrate dehydrogenase 1 (NADP+), soluble [Bos taurus]
gb|AAI03369.1| Isocitrate dehydrogenase 1 (NADP+), soluble [Bos taurus]
Length = 414
Score = 707 bits (1826), Expect = 0.0, Method: Composition-based stats.
Identities = 272/414 (65%), Positives = 333/414 (80%), Gaps = 1/414 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M++ G +VE+ GDEMTR+IW+ IKE LIFP+V + + YDL +ENRD T D+VT +A
Sbjct: 1 MSQKIQGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIKK+ VGVKCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 61 AEAIKKYNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDY-KSGGVMM 179
V+ W KP++IGRHA+GDQY ATD VV PG E+ + P++G VY V ++ +SGGV M
Sbjct: 121 VSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEISYTPSDGSPKTVYLVHNFTESGGVAM 180
Query: 180 GMYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFK 239
GMYN D SI DFA S F+ AL++ WPLYLSTKNTILK YDGRFKDIF E+Y Y+++F+
Sbjct: 181 GMYNQDKSIEDFAHSSFQMALSKNWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSEFE 240
Query: 240 TCGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDG 299
I+YEHRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDG
Sbjct: 241 AQNIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG 300
Query: 300 KTVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLE 359
KTVE EAAHGTVTRHYR YQKG+ETSTNP+ASIFAWTR LAHRA++DNN L F + LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELSFFAKALE 360
Query: 360 DVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
+V I TIEAG MT+DLA CIKG NV R+DYLNT EF+D + + L++ + ++K+
Sbjct: 361 EVCIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLQLKLAQAKL 414
>sp|Q9Z2K9|IDHC_MICME Isocitrate dehydrogenase [NADP] cytoplasmic (Cytosolic
NADP-isocitrate dehydrogenase) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP)
gb|AAD02924.1| cytosolic NADP-dependent isocitrate dehydrogenase [Microtus
mexicanus]
Length = 414
Score = 707 bits (1825), Expect = 0.0, Method: Composition-based stats.
Identities = 272/414 (65%), Positives = 328/414 (79%), Gaps = 1/414 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M+K G +VE+ GDEMTR+IW+ IKE LI P+V + + YDL +ENRD T D+VT +A
Sbjct: 1 MSKKIHGGSVVEMQGDEMTRIIWELIKEKLILPYVELDLHSYDLGIENRDATNDQVTKDA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIKK+ VGVKCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 61 AEAIKKYNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYK-SGGVMM 179
VT W KP++IGRHA+GDQY ATD VV PG E+ F P +G + Y V ++ GGV M
Sbjct: 121 VTGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITFTPKDGSQKVTYLVHSFEEGGGVAM 180
Query: 180 GMYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFK 239
GMYN D SI DFA S F+ AL++ WPLYLSTKNTILK YDGRFKDIF E+Y Y+++F+
Sbjct: 181 GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE 240
Query: 240 TCGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDG 299
I+YEHRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDG
Sbjct: 241 AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDG 300
Query: 300 KTVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLE 359
KTVE EAAHGTVTRHYR +QKG+ETSTNP+ASIFAW+R LAHRAR+DNN L F + LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMHQKGQETSTNPIASIFAWSRGLAHRARLDNNTELSFFAKALE 360
Query: 360 DVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
+V I TIEAG MT+DLA CIKG NV R+DYLNT EF+D + + LK + ++K+
Sbjct: 361 EVCIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKAKLAQAKL 414
>ref|NP_113698.1| isocitrate dehydrogenase 1 (NADP+), soluble [Rattus norvegicus]
sp|P41562|IDHC_RAT Isocitrate dehydrogenase [NADP] cytoplasmic (Cytosolic
NADP-isocitrate dehydrogenase) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP)
gb|AAA59356.1| cytosolic NADP-dependent isocitrate dehydrogenase
gb|EDL98861.1| isocitrate dehydrogenase 1 (NADP+), soluble, isoform CRA_a [Rattus
norvegicus]
gb|EDL98863.1| isocitrate dehydrogenase 1 (NADP+), soluble, isoform CRA_a [Rattus
norvegicus]
gb|EDL98864.1| isocitrate dehydrogenase 1 (NADP+), soluble, isoform CRA_a [Rattus
norvegicus]
gb|EDL98865.1| isocitrate dehydrogenase 1 (NADP+), soluble, isoform CRA_a [Rattus
norvegicus]
Length = 414
Score = 706 bits (1824), Expect = 0.0, Method: Composition-based stats.
Identities = 272/414 (65%), Positives = 328/414 (79%), Gaps = 1/414 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M++ G +VE+ GDEMTR+IW+ IKE LI P+V + + YDL +ENRD T D+VT +A
Sbjct: 1 MSRKIHGGSVVEMQGDEMTRIIWELIKEKLILPYVELDLHSYDLGIENRDATNDQVTKDA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIKK+ VGVKCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 61 AEAIKKYNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYK-SGGVMM 179
VT W KP++IGRHA+GDQY ATD VV PG E+ + P +G + Y V D++ GGV M
Sbjct: 121 VTGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPKDGSQKVTYLVHDFEEGGGVAM 180
Query: 180 GMYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFK 239
GMYN D SI DFA S F+ AL++ WPLYLSTKNTILK YDGRFKDIF E+Y Y++KF+
Sbjct: 181 GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSKFE 240
Query: 240 TCGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDG 299
I+YEHRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDG
Sbjct: 241 AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDG 300
Query: 300 KTVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLE 359
KTVE EAAHGTVTRHYR YQKG+ETSTNP+ASIFAW+R LAHRA++DNN L F LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWSRGLAHRAKLDNNTELSFFANALE 360
Query: 360 DVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
+V I TIEAG MT+DLA CIKG NV R+DYLNT EF+D + + LK + ++K+
Sbjct: 361 EVCIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKAKLAQAKL 414
>ref|XP_421965.2| PREDICTED: similar to cytosolic NADP-dependent isocitrate
dehydrogenase [Gallus gallus]
Length = 415
Score = 706 bits (1824), Expect = 0.0, Method: Composition-based stats.
Identities = 274/411 (66%), Positives = 332/411 (80%), Gaps = 1/411 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M+K G +VE+ GDEMTRVIW+ IKE LIFP+V++ + YDL +E+RD T D+VTVEA
Sbjct: 1 MSKKIHGGSVVEMQGDEMTRVIWELIKEKLIFPYVDLDLHSYDLGIEHRDATNDKVTVEA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIKK+ VG+KCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 61 AEAIKKYHVGIKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKS-GGVMM 179
V+ W KP+VIGRHA+GDQY ATD VV PG EM + P +GG+P Y V +++S GGV M
Sbjct: 121 VSGWVKPIVIGRHAYGDQYRATDFVVPGPGKVEMTYTPGDGGKPVTYLVHNFESCGGVAM 180
Query: 180 GMYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFK 239
GMYN D SI+DFA S F+ AL++ WPLY+STKNTILK YDGRFKDIF E+Y Y+++F+
Sbjct: 181 GMYNLDQSIKDFAHSSFQMALSKGWPLYMSTKNTILKRYDGRFKDIFQEIYDREYKSQFE 240
Query: 240 TCGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDG 299
I+YEHRLIDDMVA ++SEGG+VWACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDG
Sbjct: 241 AKKIWYEHRLIDDMVAQALKSEGGFVWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDG 300
Query: 300 KTVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLE 359
KTVE EAAHGTVTRHYR +QKG+ETSTNP+ASIFAWTR LAHRA++DNN +L F LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMHQKGQETSTNPIASIFAWTRGLAHRAKLDNNTSLKTFATALE 360
Query: 360 DVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQK 410
+V I TIE+G MT+DLA CIKG NV R+DYLNT EF+D ++ LK +
Sbjct: 361 EVCIETIESGFMTKDLAACIKGLPNVTRSDYLNTFEFMDKLAANLKGKLAS 411
>emb|CAM77136.1| Isocitrate/isopropylmalate dehydrogenase [Magnetospirillum
gryphiswaldense MSR-1]
Length = 405
Score = 706 bits (1823), Expect = 0.0, Method: Composition-based stats.
Identities = 260/409 (63%), Positives = 323/409 (78%), Gaps = 6/409 (1%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
MNKI +VELDGDEMTR+IWK IK+ LI P+++V ++YYDL +E RD+T D+VT++A
Sbjct: 1 MNKIKVANPIVELDGDEMTRIIWKFIKDKLILPYLDVDLKYYDLGVEYRDETNDQVTIDA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIK++GVGVKCATITPDEARVKEFNLKKMW+SPNGTIR IL GTVFREPIIC NVPRL
Sbjct: 61 AEAIKQYGVGVKCATITPDEARVKEFNLKKMWKSPNGTIRNILDGTVFREPIICQNVPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGGVMMG 180
V W KP+VIGRHAFGDQY ATD V PG M+F+ +G + ++VF++ S GV MG
Sbjct: 121 VPGWTKPIVIGRHAFGDQYRATDFKVPGPGILTMKFVGEDG-QVIEHEVFNFPSSGVAMG 179
Query: 181 MYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKT 240
MYN D+SIR FAR+C + LA+KWP+YLSTKNTILK YDGRFKDIF E+Y+ ++ +F
Sbjct: 180 MYNLDESIRGFARACMNYGLAKKWPVYLSTKNTILKAYDGRFKDIFQEVYEKEFKAEFDK 239
Query: 241 CGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGK 300
G+ YEHRLIDDMVA ++ G +VWACKNYDGDVQSD++AQGFGSLG+MTS+L++PDGK
Sbjct: 240 YGMTYEHRLIDDMVASALKWSGEFVWACKNYDGDVQSDTVAQGFGSLGLMTSVLLSPDGK 299
Query: 301 TVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLED 360
TVE EAAHGTVTRHYR++QKGKETSTNP+ASIFAWTR L +RA+ DN + +F LE+
Sbjct: 300 TVEAEAAHGTVTRHYREHQKGKETSTNPIASIFAWTRGLLYRAQFDNTPEVAKFATALEE 359
Query: 361 VIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQ 409
V + T+EAG MT+DLAI I ++ +L T +F+D + + LK M
Sbjct: 360 VCVETVEAGFMTKDLAILIGPDQP-----WLTTTQFLDKLDENLKKKMG 403
>sp|Q9Z2K8|IDHC_MICOH Isocitrate dehydrogenase [NADP] cytoplasmic (Cytosolic
NADP-isocitrate dehydrogenase) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP)
gb|AAD02925.1| cytosolic NADP-dependent isocitrate dehydrogenase [Microtus
ochrogaster]
Length = 414
Score = 706 bits (1823), Expect = 0.0, Method: Composition-based stats.
Identities = 271/414 (65%), Positives = 328/414 (79%), Gaps = 1/414 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M+K G +VE+ GDEMTR+IW+ IKE LI P+V + + YDL +ENRD T D+VT +A
Sbjct: 1 MSKKIHGGSVVEMQGDEMTRIIWELIKEKLILPYVELDLHSYDLGIENRDATNDQVTKDA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIKK+ VGVKCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 61 AEAIKKYNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYK-SGGVMM 179
VT W KP++IGRHA+GDQY ATD VV PG E+ + P +G + Y V ++ GGV M
Sbjct: 121 VTGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPKDGSQKVTYLVHSFEEGGGVAM 180
Query: 180 GMYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFK 239
GMYN D SI DFA S F+ AL++ WPLYLSTKNTILK YDGRFKDIF E+Y Y+++F+
Sbjct: 181 GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE 240
Query: 240 TCGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDG 299
I+YEHRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDG
Sbjct: 241 AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDG 300
Query: 300 KTVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLE 359
KTVE EAAHGTVTRHYR +QKG+ETSTNP+ASIFAW+R LAHRAR+DNN L F + LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMHQKGQETSTNPIASIFAWSRGLAHRARLDNNTELSFFAKALE 360
Query: 360 DVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
+V I TIEAG MT+DLA CIKG NV R+DYLNT EF+D + + LK + ++K+
Sbjct: 361 EVCIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKAKLAQAKL 414
>emb|CAG38738.1| IDH1 [Homo sapiens]
Length = 414
Score = 706 bits (1823), Expect = 0.0, Method: Composition-based stats.
Identities = 274/414 (66%), Positives = 332/414 (80%), Gaps = 1/414 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M+K + G +VE+ GDEMTR+IW+ IKE LIFP+V + + YDL +ENRD T D+VT +A
Sbjct: 1 MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIKKH VGVKCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 61 AEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYK-SGGVMM 179
V+ W KP++IGRHA+GDQY ATD VV PG EM + P++G + Y V +++ GGV M
Sbjct: 121 VSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEMTYTPSDGTQKVTYLVHNFEEGGGVAM 180
Query: 180 GMYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFK 239
GMYN D SI DFA S F+ AL++ WPLYLSTKNTILK YDGRFKDIF E+Y Y+++F+
Sbjct: 181 GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE 240
Query: 240 TCGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDG 299
I+YEHRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDG
Sbjct: 241 AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG 300
Query: 300 KTVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLE 359
KTVE EAAHGTVTRHYR YQKG+ETSTNP+ASIFAWTR LAHRA++DNN L F LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALE 360
Query: 360 DVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
+V I TIEAG MT+DLA CIKG NV R+DYLNT EF+D + + LK+ + ++K+
Sbjct: 361 EVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL 414
>ref|NP_001009276.1| cytosolic NADP-isocitrate dehydrogenase [Ovis aries]
sp|Q6XUZ5|IDHC_SHEEP Isocitrate dehydrogenase [NADP] cytoplasmic (Cytosolic
NADP-isocitrate dehydrogenase) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP)
gb|AAP41947.1| cytosolic NADP-isocitrate dehydrogenase [Ovis aries]
Length = 414
Score = 706 bits (1822), Expect = 0.0, Method: Composition-based stats.
Identities = 272/414 (65%), Positives = 334/414 (80%), Gaps = 1/414 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M+ G +VE+ GDEMTR+IW+ IKE LIFP+V++ + YDLS+ENRD T D+VT +A
Sbjct: 1 MSHKIQGGSVVEMQGDEMTRIIWELIKEKLIFPYVDLDLHSYDLSIENRDATNDQVTKDA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIKK+ VGVKCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 61 AEAIKKYNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDY-KSGGVMM 179
V+ W KP++IGRHA+GDQY ATD VV PG E+ + P++G VY V ++ +SGGV M
Sbjct: 121 VSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEICYTPSDGSPKTVYLVHNFTESGGVAM 180
Query: 180 GMYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFK 239
GM+N D SI DFA S F+ AL++ WPLYLSTKNTILK YDGRFKDIF E+Y Y+++F+
Sbjct: 181 GMFNQDKSIEDFAHSSFQMALSKNWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE 240
Query: 240 TCGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDG 299
I+YEHRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDG
Sbjct: 241 AQNIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG 300
Query: 300 KTVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLE 359
KTVE EAAHGTVTRHYR YQKG+ETSTNP+ASIFAWTR LAHRA++DNN L F + LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELSFFAKALE 360
Query: 360 DVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
+V I TIEAG MT+DLA CIKG NV R+DYLNT EF+D + + L++ + ++K+
Sbjct: 361 EVCIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLQLKLAQAKL 414
>ref|XP_850187.1| PREDICTED: similar to Isocitrate dehydrogenase [NADP] cytoplasmic
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) (IDP) isoform 2 [Canis familiaris]
ref|XP_536047.2| PREDICTED: similar to Isocitrate dehydrogenase [NADP] cytoplasmic
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) (IDP) isoform 1 [Canis familiaris]
Length = 414
Score = 705 bits (1821), Expect = 0.0, Method: Composition-based stats.
Identities = 270/414 (65%), Positives = 331/414 (79%), Gaps = 1/414 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M++ G +VE+ GDEMTR+IW+ IKE LIFP+V + + YDL +ENRD T D+VT +A
Sbjct: 1 MSQKIRGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIKK+ VGVKCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 61 AEAIKKYNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYK-SGGVMM 179
V+ W KP++IGRHA+GDQY ATD VV PG E+ + P++G E Y V +++ GGV M
Sbjct: 121 VSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGSEKMTYLVHNFEEGGGVAM 180
Query: 180 GMYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFK 239
GMYN D SI DFA S F+ AL++ WPLYLSTKNTILK YDGRFKDIF E+Y Y+++F+
Sbjct: 181 GMYNQDKSIEDFAHSSFQMALSKSWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE 240
Query: 240 TCGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDG 299
I+YEHRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDG
Sbjct: 241 AQNIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG 300
Query: 300 KTVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLE 359
KTVE EAAHGTVTRHYR YQKG+ETSTNP+ASIFAWTR LAHRA++DNN L F + LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELSFFAKALE 360
Query: 360 DVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
+V + TIEAG MT+DLA CIKG NV R+DYLNT EF+D + + L + + ++K+
Sbjct: 361 EVCVETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLNIKLAQAKL 414
>ref|NP_005887.2| isocitrate dehydrogenase 1 (NADP+), soluble [Homo sapiens]
sp|O75874|IDHC_HUMAN Isocitrate dehydrogenase [NADP] cytoplasmic (Cytosolic
NADP-isocitrate dehydrogenase) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP)
pdb|1T09|A Chain A, Crystal Structure Of Human Cytosolic Nadp(+)-Dependent
Isocitrate Dehydrogenase In Complex Nadp
pdb|1T09|B Chain B, Crystal Structure Of Human Cytosolic Nadp(+)-Dependent
Isocitrate Dehydrogenase In Complex Nadp
pdb|1T0L|A Chain A, Crystal Structure Of Human Cytosolic Nadp(+)-Dependent
Isocitrate Dehydrogenase In Complex With Nadp,
Isocitrate, And Calcium(2+)
pdb|1T0L|B Chain B, Crystal Structure Of Human Cytosolic Nadp(+)-Dependent
Isocitrate Dehydrogenase In Complex With Nadp,
Isocitrate, And Calcium(2+)
pdb|1T0L|C Chain C, Crystal Structure Of Human Cytosolic Nadp(+)-Dependent
Isocitrate Dehydrogenase In Complex With Nadp,
Isocitrate, And Calcium(2+)
pdb|1T0L|D Chain D, Crystal Structure Of Human Cytosolic Nadp(+)-Dependent
Isocitrate Dehydrogenase In Complex With Nadp,
Isocitrate, And Calcium(2+)
gb|AAD29284.1|AF113917_1 NADP+-dependent isocitrate dehydrogenase [Homo sapiens]
gb|AAH12846.1| IDH1 protein [Homo sapiens]
emb|CAG46496.1| IDH1 [Homo sapiens]
gb|AAX93221.1| unknown [Homo sapiens]
gb|EAW70439.1| isocitrate dehydrogenase 1 (NADP+), soluble, isoform CRA_a [Homo
sapiens]
gb|EAW70441.1| isocitrate dehydrogenase 1 (NADP+), soluble, isoform CRA_a [Homo
sapiens]
gb|EAW70442.1| isocitrate dehydrogenase 1 (NADP+), soluble, isoform CRA_a [Homo
sapiens]
gb|ABM82361.1| isocitrate dehydrogenase 1 (NADP+), soluble [synthetic construct]
gb|ABW03396.1| isocitrate dehydrogenase 1 (NADP+), soluble [synthetic construct]
Length = 414
Score = 705 bits (1821), Expect = 0.0, Method: Composition-based stats.
Identities = 273/414 (65%), Positives = 332/414 (80%), Gaps = 1/414 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M+K + G +VE+ GDEMTR+IW+ IKE LIFP+V + + YDL +ENRD T D+VT +A
Sbjct: 1 MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIKKH VGVKCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 61 AEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYK-SGGVMM 179
V+ W KP++IGRHA+GDQY ATD VV PG E+ + P++G + Y V +++ GGV M
Sbjct: 121 VSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAM 180
Query: 180 GMYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFK 239
GMYN D SI DFA S F+ AL++ WPLYLSTKNTILK YDGRFKDIF E+Y Y+++F+
Sbjct: 181 GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE 240
Query: 240 TCGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDG 299
I+YEHRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDG
Sbjct: 241 AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG 300
Query: 300 KTVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLE 359
KTVE EAAHGTVTRHYR YQKG+ETSTNP+ASIFAWTR LAHRA++DNN L F LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALE 360
Query: 360 DVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
+V I TIEAG MT+DLA CIKG NV R+DYLNT EF+D + + LK+ + ++K+
Sbjct: 361 EVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL 414
>gb|ABU41004.1| isocitrate dehydrogenase 1 [Anser anser]
Length = 415
Score = 705 bits (1820), Expect = 0.0, Method: Composition-based stats.
Identities = 273/411 (66%), Positives = 333/411 (81%), Gaps = 1/411 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M+K G +VE+ GDEMTRVIW+ IKE LIFP+V++ + YDL +E+RD T D+VTVEA
Sbjct: 1 MSKKIHGGSVVEMQGDEMTRVIWELIKEKLIFPYVDLDLHSYDLGIEHRDATNDKVTVEA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIKK+ VG+KCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 61 AEAIKKYHVGIKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKS-GGVMM 179
V+ W KP+VIGRHA+GDQY ATD VV PG EM + P +GG+P Y V +++S GGV M
Sbjct: 121 VSGWVKPIVIGRHAYGDQYRATDFVVPGPGKVEMTYTPGDGGKPVTYLVHNFESCGGVAM 180
Query: 180 GMYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFK 239
GM+N D SI+DFA S F+ AL++ WPLY+STKNTILK YDGRFKDIF E+Y Y+++F+
Sbjct: 181 GMFNLDQSIKDFAHSSFQMALSKGWPLYMSTKNTILKRYDGRFKDIFQEIYDREYKSQFE 240
Query: 240 TCGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDG 299
I+YEHRLIDDMVA ++SEGG+VWACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDG
Sbjct: 241 AKKIWYEHRLIDDMVAQALKSEGGFVWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDG 300
Query: 300 KTVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLE 359
KTVE EAAHGTVTRHYR +QKG+ETSTNP+ASIFAWTR LAHRA++DNN +L F LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMHQKGQETSTNPIASIFAWTRGLAHRAKLDNNTSLKTFAAALE 360
Query: 360 DVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQK 410
+V I TIE+G MT+DLA CIKG NV R+DYLNT EF+D +++ LK +
Sbjct: 361 EVCIETIESGFMTKDLAACIKGLPNVTRSDYLNTFEFMDKLAENLKGKLAS 411
>sp|Q9XSG3|IDHC_BOVIN Isocitrate dehydrogenase [NADP] cytoplasmic (Cytosolic
NADP-isocitrate dehydrogenase) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP)
gb|AAD34457.1|AF136009_1 cytosolic NADP+-dependent isocitrate dehydrogenase [Bos taurus]
Length = 414
Score = 705 bits (1820), Expect = 0.0, Method: Composition-based stats.
Identities = 271/414 (65%), Positives = 332/414 (80%), Gaps = 1/414 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M++ G +VE+ GDEMTR+IW+ IKE LIFP+V + + YDL +ENRD T D+VT +A
Sbjct: 1 MSQKIQGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIKK+ VGVKCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 61 AEAIKKYNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDY-KSGGVMM 179
V+ W KP++IGRHA+GDQY ATD VV PG E+ + P++G VY V ++ +SGGV M
Sbjct: 121 VSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEISYTPSDGSPKTVYLVHNFTESGGVAM 180
Query: 180 GMYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFK 239
GMYN D SI DFA S F+ AL++ WPLYLSTKNTILK YDGRFKDIF E+Y Y+++F+
Sbjct: 181 GMYNQDKSIEDFAHSSFQMALSKNWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSEFE 240
Query: 240 TCGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDG 299
I+YEHRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDG
Sbjct: 241 AQNIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG 300
Query: 300 KTVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLE 359
KTVE EAAHGTVTRHYR YQKG+ET TNP+ASIFAWTR LAHRA++DNN L F + LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMYQKGQETLTNPIASIFAWTRGLAHRAKLDNNKELSFFAKALE 360
Query: 360 DVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
+V I TIEAG MT+DLA CIKG NV R+DYLNT EF+D + + L++ + ++K+
Sbjct: 361 EVCIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLQLKLAQAKL 414
>ref|XP_001168291.1| PREDICTED: isocitrate dehydrogenase 2 (NADP+), mitochondrial
isoform 2 [Pan troglodytes]
Length = 475
Score = 705 bits (1820), Expect = 0.0, Method: Composition-based stats.
Identities = 255/433 (58%), Positives = 320/433 (73%), Gaps = 24/433 (5%)
Query: 3 KISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEAAY 62
+I +VE+DGDEMTR+IW+ IKE LI P V++ ++Y+DL + NRD+T+D+VT+++A
Sbjct: 43 RIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSAL 102
Query: 63 AIKKHGVGVKCATITPDEARVK-----------------------EFNLKKMWRSPNGTI 99
A +K+ V VKCATITPDEARV+ EF LKKMW+SPNGTI
Sbjct: 103 ATQKYSVAVKCATITPDEARVEVGGSWRTVLEIHLQTPQACPCPAEFKLKKMWKSPNGTI 162
Query: 100 RTILGGTVFREPIICSNVPRLVTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPA 159
R ILGGTVFREPIIC N+PRLV W KP+ IGRHA GDQY ATD V GTF+M F P
Sbjct: 163 RNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPK 222
Query: 160 NGGEPKVYKVFDYKSGGVMMGMYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYD 219
+G K ++V+++ +GGV MGMYNTD+SI FA SCF++A+ +KWPLY+STKNTILK YD
Sbjct: 223 DGSGVKEWEVYNFPAGGVGMGMYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYD 282
Query: 220 GRFKDIFAEMYKALYETKFKTCGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDS 279
GRFKDIF E++ Y+T F I+YEHRLIDDMVA ++S GG+VWACKNYDGDVQSD
Sbjct: 283 GRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDI 342
Query: 280 LAQGFGSLGMMTSILMTPDGKTVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRAL 339
LAQGFGSLG+MTS+L+ PDGKT+E EAAHGTVTRHYR++QKG+ TSTNP+ASIFAWTR L
Sbjct: 343 LAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGL 402
Query: 340 AHRARVDNNNTLLEFTQRLEDVIIATIEAGAMTEDLAICIKGEKNVV-RADYLNTDEFID 398
HR ++D N L+ F Q LE V + T+E+GAMT+DLA CI G NV +LNT +F+D
Sbjct: 403 EHRGKLDGNQDLIRFAQTLEKVCVETVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLD 462
Query: 399 AVSQRLKVAMQKS 411
+ L A+ +
Sbjct: 463 TIKSNLDRALGRQ 475
>ref|NP_001088022.1| hypothetical protein LOC494713 [Xenopus laevis]
gb|AAH82651.1| LOC494713 protein [Xenopus laevis]
Length = 415
Score = 705 bits (1820), Expect = 0.0, Method: Composition-based stats.
Identities = 270/411 (65%), Positives = 329/411 (80%), Gaps = 1/411 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M+K G +VE+ GDEMTRVIW IKE LI P+V + + YDL MENRD T+D+VTV+A
Sbjct: 1 MSKKINGGSVVEMQGDEMTRVIWDLIKEKLILPYVELDLHSYDLGMENRDATDDQVTVDA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIKK+ VG+KCATITPDE RV+EFNLK+MW+SPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 61 AEAIKKYNVGIKCATITPDEKRVEEFNLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKS-GGVMM 179
V+ W KP++IGRHA+GDQY ATD VV PG E+ F P +GGE Y + +++ GGV +
Sbjct: 121 VSGWIKPIIIGRHAYGDQYRATDFVVPGPGKVEISFTPKDGGEAIKYVIHNFEDCGGVAL 180
Query: 180 GMYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFK 239
GMYNTD SIRDFA S F+ AL++ WPLY+STKNTILK YDGRFKDIF E+Y+ Y+++F+
Sbjct: 181 GMYNTDQSIRDFAHSSFQMALSKSWPLYMSTKNTILKRYDGRFKDIFQEIYEKEYKSQFE 240
Query: 240 TCGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDG 299
I+YEHRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDG
Sbjct: 241 ENKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDG 300
Query: 300 KTVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLE 359
KTVE EAAHGTVTRHYR +QKG+ETSTNP+ASIFAW+R L HRA++DNN L F LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMHQKGQETSTNPIASIFAWSRGLDHRAKLDNNQELKNFATALE 360
Query: 360 DVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQK 410
+V I TIEAG MT+DLA CIKG NV R DYL+T EF+D + + L++ +
Sbjct: 361 EVCIETIEAGFMTKDLAACIKGLPNVQRGDYLSTFEFMDKLGENLQLKLAA 411
>ref|NP_539708.1| isocitrate dehydrogenase [Brucella melitensis 16M]
ref|YP_221903.1| isocitrate dehydrogenase [Brucella abortus biovar 1 str. 9-941]
ref|YP_414607.1| isocitrate dehydrogenase [Brucella melitensis biovar Abortus 2308]
ref|YP_001259118.1| isocitrate dehydrogenase [Brucella ovis ATCC 25840]
ref|YP_001935116.1| Isocitrate/isopropylmalate dehydrogenase [Brucella abortus S19]
gb|AAL51972.1| ISOCITRATE DEHYDROGENASE (NADP) [Brucella melitensis 16M]
gb|AAX74542.1| isocitrate dehydrogenase, NADP-dependent [Brucella abortus biovar 1
str. 9-941]
emb|CAJ11177.1| Isocitrate/isopropylmalate dehydrogenase:Isocitrate dehydrogenase
NADP-dependent, eukaryotic [Brucella melitensis biovar
Abortus 2308]
gb|ABQ61375.1| isocitrate dehydrogenase, NADP-dependent [Brucella ovis ATCC 25840]
gb|ACD72642.1| Isocitrate/isopropylmalate dehydrogenase [Brucella abortus S19]
Length = 404
Score = 704 bits (1819), Expect = 0.0, Method: Composition-based stats.
Identities = 252/410 (61%), Positives = 321/410 (78%), Gaps = 6/410 (1%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M KI +VELDGDEMTR+IW+ IK+ LI P++++ ++YYDLS+ENRD T D+VT++A
Sbjct: 1 MAKIKVANPVVELDGDEMTRIIWQFIKDKLIHPYLDIDLKYYDLSVENRDATNDQVTIDA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIK++GVGVKCATITPDEARV+EF LKKMW+SPNGTIR ILGG +FREPIIC NVPRL
Sbjct: 61 ANAIKEYGVGVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGVIFREPIICKNVPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGGVMMG 180
V W +P+++GRHAFGDQY ATD GT ++F+ +G + ++V+ S GV M
Sbjct: 121 VPGWTQPIIVGRHAFGDQYRATDFKFPGKGTLTIKFVGEDG-QTIEHEVYQAPSAGVAMA 179
Query: 181 MYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKT 240
MYN D+SIR+FAR+ F + L R +P+YLSTKNTILK YDGRFKDIF E++ A +++KF+
Sbjct: 180 MYNLDESIREFARASFNYGLQRGYPVYLSTKNTILKAYDGRFKDIFQEVFDAEFKSKFEE 239
Query: 241 CGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGK 300
I+YEHRLIDDMVA ++ GGYVWACKNYDGDVQSD +AQGFGSLG+MTS+LMTPDGK
Sbjct: 240 KKIWYEHRLIDDMVASALKWSGGYVWACKNYDGDVQSDIVAQGFGSLGLMTSVLMTPDGK 299
Query: 301 TVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLED 360
TVE EAAHGTVTRHYR +QKG+ETSTN +ASIFAWTR LAHRA++DNN L +F + LE
Sbjct: 300 TVEAEAAHGTVTRHYRQHQKGEETSTNSIASIFAWTRGLAHRAKLDNNADLKKFAETLEK 359
Query: 361 VIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQK 410
V + T+E+G MT+DLA+ I ++ +L+T F+D + + L+ AM
Sbjct: 360 VCVDTVESGFMTKDLALLIGPDQP-----WLSTTGFLDKIDENLQKAMAA 404
>ref|XP_001141655.1| PREDICTED: isocitrate dehydrogenase 1 (NADP+), soluble isoform 1
[Pan troglodytes]
ref|XP_001141734.1| PREDICTED: isocitrate dehydrogenase 1 (NADP+), soluble isoform 2
[Pan troglodytes]
ref|XP_001141810.1| PREDICTED: isocitrate dehydrogenase 1 (NADP+), soluble isoform 3
[Pan troglodytes]
ref|XP_001141879.1| PREDICTED: isocitrate dehydrogenase 1 (NADP+), soluble isoform 4
[Pan troglodytes]
ref|XP_001141947.1| PREDICTED: isocitrate dehydrogenase 1 (NADP+), soluble isoform 5
[Pan troglodytes]
ref|XP_001142041.1| PREDICTED: isocitrate dehydrogenase 1 (NADP+), soluble isoform 6
[Pan troglodytes]
ref|XP_001142113.1| PREDICTED: isocitrate dehydrogenase 1 (NADP+), soluble isoform 7
[Pan troglodytes]
ref|XP_001142197.1| PREDICTED: isocitrate dehydrogenase 1 (NADP+), soluble isoform 8
[Pan troglodytes]
Length = 414
Score = 704 bits (1818), Expect = 0.0, Method: Composition-based stats.
Identities = 272/414 (65%), Positives = 332/414 (80%), Gaps = 1/414 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M+K + G +VE+ GDEMTR+IW+ IKE LIFP+V + + YDL +ENRD T D+VT +A
Sbjct: 1 MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIKK+ VGVKCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 61 AEAIKKYNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYK-SGGVMM 179
V+ W KP++IGRHA+GDQY ATD VV PG E+ + P++G + Y V +++ GGV M
Sbjct: 121 VSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAM 180
Query: 180 GMYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFK 239
GMYN D SI DFA S F+ AL++ WPLYLSTKNTILK YDGRFKDIF E+Y Y+++F+
Sbjct: 181 GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKRYKSQFE 240
Query: 240 TCGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDG 299
I+YEHRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDG
Sbjct: 241 AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG 300
Query: 300 KTVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLE 359
KTVE EAAHGTVTRHYR YQKG+ETSTNP+ASIFAWTR LAHRA++DNN L F LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALE 360
Query: 360 DVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
+V I TIEAG MT+DLA CIKG NV R+DYLNT EF+D + + LK+ + ++K+
Sbjct: 361 EVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL 414
>sp|Q5R9C5|IDHC_PONPY Isocitrate dehydrogenase [NADP] cytoplasmic (Cytosolic
NADP-isocitrate dehydrogenase) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP)
Length = 414
Score = 704 bits (1818), Expect = 0.0, Method: Composition-based stats.
Identities = 271/414 (65%), Positives = 332/414 (80%), Gaps = 1/414 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M+K + G +VE+ GDEMTR+IW+ IKE LIFP+V + + YDL +ENRD T D+VT +A
Sbjct: 1 MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIKK+ VGVKCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 61 AEAIKKYNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYK-SGGVMM 179
V+ W KP++IGRHA+GDQY ATD VV PG E+ + P++G + Y V +++ GGV M
Sbjct: 121 VSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAM 180
Query: 180 GMYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFK 239
GMYN D SI DFA S F+ AL++ WPLYLSTKNTILK YDGRFKDIF E+Y Y+++F+
Sbjct: 181 GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE 240
Query: 240 TCGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDG 299
I+YEHRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDG
Sbjct: 241 ARKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG 300
Query: 300 KTVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLE 359
KTVE EAAHGTVTRHYR YQKG+ETSTNP+ASIFAWTR LAHRA++DNN L F LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALE 360
Query: 360 DVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
+V + TIEAG MT+DLA CIKG NV R+DYLNT EF+D + + LK+ + ++K+
Sbjct: 361 EVSVETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL 414
>ref|NP_001080321.1| hypothetical protein LOC380013 [Xenopus laevis]
gb|AAH54241.1| MGC64442 protein [Xenopus laevis]
Length = 454
Score = 704 bits (1817), Expect = 0.0, Method: Composition-based stats.
Identities = 252/411 (61%), Positives = 321/411 (78%), Gaps = 2/411 (0%)
Query: 3 KISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEAAY 62
+I +VE+DGDEMTR+IW+ IKE LI V+V ++Y+DL + RD+T+D+VT+++A
Sbjct: 44 RIKVANPVVEMDGDEMTRIIWEFIKEKLILSNVDVELKYFDLGLPYRDQTDDQVTIDSAL 103
Query: 63 AIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRLVT 122
A K+ V VKCATITPDEARV+EF LKKMW+SPNGT+R ILGGTVFREPIIC N+PRLV
Sbjct: 104 ATLKYNVAVKCATITPDEARVEEFKLKKMWKSPNGTVRNILGGTVFREPIICKNIPRLVP 163
Query: 123 TWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGGVMMGMY 182
W + + IGRHA GDQY ATD VV + GTF+M F PANG K ++VF + +GGV MGMY
Sbjct: 164 GWTQAITIGRHAHGDQYKATDFVVDQAGTFKMVFTPANGTATKEWEVFKFPAGGVGMGMY 223
Query: 183 NTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKTCG 242
NTD+SI FA SCF++A+ +KWPLY+STKNTILK YDGRFKDIF ++++ Y+ F
Sbjct: 224 NTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQDIFEKHYKPDFDKVK 283
Query: 243 IFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGKTV 302
I+YEHRLIDDMVA ++S GG+VWACKNYDGDVQSD LAQGFGSLG+M+S+L+ PDGKT+
Sbjct: 284 IWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMSSVLVCPDGKTI 343
Query: 303 EVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLEDVI 362
E EAAHGTVTRHYR++QKG+ TSTNP+ASIFAWTR L HR ++D N L+ F+ +LE V
Sbjct: 344 EAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLINFSLKLEKVC 403
Query: 363 IATIEAGAMTEDLAICIKGEKNVVR--ADYLNTDEFIDAVSQRLKVAMQKS 411
+ T+E+G MT+DLA CI G + VR Y+NT +F+DA+ L A+ K+
Sbjct: 404 VETVESGIMTKDLAGCIHGGMSNVRLNEHYVNTTDFLDAIKNNLDKALGKN 454
>gb|AAH93020.1| Isocitrate dehydrogenase 1 (NADP+), soluble [Homo sapiens]
Length = 414
Score = 703 bits (1816), Expect = 0.0, Method: Composition-based stats.
Identities = 272/414 (65%), Positives = 332/414 (80%), Gaps = 1/414 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M+K + G +VE+ GDEMTR+IW+ IKE LIFP+V + + YDL +ENRD T D+VT +A
Sbjct: 1 MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIKKH VGVKCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 61 AEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYK-SGGVMM 179
V+ W KP++IGRHA+GDQY ATD VV PG E+ + P++G + Y V +++ GGV M
Sbjct: 121 VSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAM 180
Query: 180 GMYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFK 239
GMYN D SI DFA S F+ AL++ WPLYLSTKNTILK YDGRFKDIF E+Y Y+++F+
Sbjct: 181 GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE 240
Query: 240 TCGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDG 299
I+YEHRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDG
Sbjct: 241 AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG 300
Query: 300 KTVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLE 359
KTVE E+AHGTVTRHYR YQKG+ETSTNP+ASIFAWTR LAHRA++DNN L F LE
Sbjct: 301 KTVEAESAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALE 360
Query: 360 DVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
+V I TIEAG MT+DLA CIKG NV R+DYLNT EF+D + + LK+ + ++K+
Sbjct: 361 EVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL 414
>ref|NP_698203.1| isocitrate dehydrogenase [Brucella suis 1330]
ref|YP_001593041.1| isocitrate dehydrogenase, NADP-dependent [Brucella canis ATCC
23365]
ref|YP_001627868.1| isocitrate dehydrogenase, NADP-dependent [Brucella suis ATCC 23445]
gb|AAN30118.1| isocitrate dehydrogenase, NADP-dependent [Brucella suis 1330]
gb|ABX62270.1| isocitrate dehydrogenase, NADP-dependent [Brucella canis ATCC
23365]
gb|ABY38298.1| isocitrate dehydrogenase, NADP-dependent [Brucella suis ATCC 23445]
Length = 404
Score = 703 bits (1816), Expect = 0.0, Method: Composition-based stats.
Identities = 253/410 (61%), Positives = 321/410 (78%), Gaps = 6/410 (1%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M KI +VELDGDEMTR+IW+ IK+ LI P++++ ++YYDLS+ENRD T D+VT++A
Sbjct: 1 MAKIKVANPVVELDGDEMTRIIWQFIKDKLIHPYLDIDLKYYDLSVENRDATNDQVTIDA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIK++GVGVKCATITPDEARV+EF LKKMW+SPNGTIR ILGG +FREPIIC NVPRL
Sbjct: 61 ANAIKEYGVGVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGVIFREPIICKNVPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGGVMMG 180
V W +P+++GRHAFGDQY ATD GT ++F+ +G + ++V+ S GV M
Sbjct: 121 VPGWTQPIIVGRHAFGDQYRATDFKFPGKGTLTIKFVGEDG-QTIEHEVYQAPSAGVAMA 179
Query: 181 MYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKT 240
MYN D+SIR+FAR+ F + L R +P+YLSTKNTILK YDGRFKDIF E++ A +++KF+
Sbjct: 180 MYNLDESIREFARASFNYGLQRGYPVYLSTKNTILKAYDGRFKDIFQEVFDAEFKSKFEE 239
Query: 241 CGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGK 300
I+YEHRLIDDMVA ++ GGYVWACKNYDGDVQSD +AQGFGSLG+MTS+LMTPDGK
Sbjct: 240 KKIWYEHRLIDDMVASALKWSGGYVWACKNYDGDVQSDIVAQGFGSLGLMTSVLMTPDGK 299
Query: 301 TVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLED 360
TVE EAAHGTVTRHYR YQKG+ETSTN +ASIFAWTR LAHRA++DNN L +F + LE
Sbjct: 300 TVEAEAAHGTVTRHYRQYQKGEETSTNSIASIFAWTRGLAHRAKLDNNADLKKFAETLEK 359
Query: 361 VIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQK 410
V + T+E+G MT+DLA+ I ++ +L+T F+D + + L+ AM
Sbjct: 360 VCVDTVESGFMTKDLALLIGPDQP-----WLSTTGFLDKIDENLQKAMAA 404
>emb|CAG13105.1| unnamed protein product [Tetraodon nigroviridis]
Length = 415
Score = 703 bits (1815), Expect = 0.0, Method: Composition-based stats.
Identities = 255/409 (62%), Positives = 324/409 (79%), Gaps = 1/409 (0%)
Query: 3 KISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEAAY 62
+I +VE+DGDEMTR+IW+ IKE LI V+V ++Y+DL + RD+T+D+VT+++A
Sbjct: 7 RIKVAQPVVEMDGDEMTRIIWEFIKEKLILTNVDVELKYFDLGLPYRDQTDDQVTIDSAL 66
Query: 63 AIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRLVT 122
A KK+ V VKCATITPDEARV+EF LKKMW+SPNGTIR ILGGTVFREPIIC N+PRLV
Sbjct: 67 ATKKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICRNIPRLVP 126
Query: 123 TWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGGVMMGMY 182
W +P+ IGRHAFGDQY ATD VV +PG F++ F PA+G K ++V+D+ +GG MGMY
Sbjct: 127 GWTQPITIGRHAFGDQYRATDFVVDKPGKFKIVFSPADGSSAKEWEVYDFPAGGCGMGMY 186
Query: 183 NTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKTCG 242
NTD+SI FA SCF++A+ +KWPLY+STKNTILK YDGRFKDIF ++++ Y+ +F
Sbjct: 187 NTDESITGFAHSCFQYAIGKKWPLYMSTKNTILKAYDGRFKDIFQDIFEKHYKPEFDKLK 246
Query: 243 IFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGKTV 302
I+YEHRLIDDMVA ++S G +VWACKNYDGDVQSD LAQGFGSLG+MTS+L+ PDGKT+
Sbjct: 247 IWYEHRLIDDMVAQVLKSSGAFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTI 306
Query: 303 EVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLEDVI 362
E EAAHGTVTRHYR++QKG+ TSTNP+ASIFAWTR L HR ++D NN L++F+Q LE V
Sbjct: 307 EAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNNDLIKFSQTLERVC 366
Query: 363 IATIEAGAMTEDLAICIKGEKNVV-RADYLNTDEFIDAVSQRLKVAMQK 410
+ T+E+G MT+DLA CI G NV Y+NT +F+DA+ L A+ K
Sbjct: 367 VETVESGTMTKDLAGCIHGLPNVKLNEHYVNTTDFLDAIRTNLDKALGK 415
>ref|XP_001505172.1| PREDICTED: similar to Isocitrate dehydrogenase [NADP] cytoplasmic
(Cytosolic NADP-isocitrate dehydrogenase)
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) (IDP) [Equus caballus]
Length = 414
Score = 703 bits (1815), Expect = 0.0, Method: Composition-based stats.
Identities = 271/414 (65%), Positives = 331/414 (79%), Gaps = 1/414 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M++ G +VE+ GDEMTR+IW+ IKE LIFP V + + YDL +ENRD T D+VT +A
Sbjct: 1 MSQKIRGGSVVEMQGDEMTRIIWELIKEKLIFPHVELDLHSYDLGIENRDATNDQVTKDA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIKK+ VGVKCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 61 AEAIKKYNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYK-SGGVMM 179
V+ W KP++IGRHA+GDQY ATD VV PG E+ + P++G + + Y V +++ GGV M
Sbjct: 121 VSGWVKPIIIGRHAYGDQYRATDFVVPGPGRVEITYTPSDGSQKRTYLVHNFEEGGGVAM 180
Query: 180 GMYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFK 239
GMYN D SI DFA S F+ AL++ WPLYLSTKNTILK YDGRFKDIF E+Y Y ++F+
Sbjct: 181 GMYNQDKSIEDFAHSSFQMALSKSWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYRSQFE 240
Query: 240 TCGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDG 299
I+YEHRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDG
Sbjct: 241 AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG 300
Query: 300 KTVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLE 359
KTVE EAAHGTVTRHYR YQKG+ETSTNP+ASIFAWTR LAHRA++DNN L F + LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELGFFAKALE 360
Query: 360 DVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
DV + TIEAG MT+DLA CIKG NV R+DYLNT EF+D + + LK+ + ++K+
Sbjct: 361 DVCVETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL 414
>emb|CAD97653.1| hypothetical protein [Homo sapiens]
emb|CAL38069.1| hypothetical protein [synthetic construct]
emb|CAL37462.1| hypothetical protein [synthetic construct]
Length = 414
Score = 703 bits (1814), Expect = 0.0, Method: Composition-based stats.
Identities = 273/414 (65%), Positives = 331/414 (79%), Gaps = 1/414 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M+K + G +VE+ GDEMTR+IW+ IKE LIFP+V + + YDL +ENRD T D+VT +A
Sbjct: 1 MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIKKH VGVKCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 61 AEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYKSGG-VMM 179
V+ W KP++IGRHA+GDQY ATD VV PG E+ + P++G + Y V + + GG V M
Sbjct: 121 VSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNSEGGGGVAM 180
Query: 180 GMYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFK 239
GMYN D SI DFA S F+ AL++ WPLYLSTKNTILK YDGRFKDIF E+Y Y+++F+
Sbjct: 181 GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE 240
Query: 240 TCGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDG 299
I+YEHRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDG
Sbjct: 241 AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG 300
Query: 300 KTVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLE 359
KTVE EAAHGTVTRHYR YQKG+ETSTNP+ASIFAWTR LAHRA++DNN L F LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALE 360
Query: 360 DVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
+V I TIEAG MT+DLA CIKG NV R+DYLNT EF+D + + LK+ + ++K+
Sbjct: 361 EVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL 414
>sp|O88844|IDHC_MOUSE Isocitrate dehydrogenase [NADP] cytoplasmic (Cytosolic
NADP-isocitrate dehydrogenase) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP)
gb|AAD02919.1| NADP-dependent isocitrate dehydrogenase [Mus musculus]
Length = 414
Score = 703 bits (1814), Expect = 0.0, Method: Composition-based stats.
Identities = 272/414 (65%), Positives = 328/414 (79%), Gaps = 1/414 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M++ G +VE+ GDEMTR+IW+ IKE LI P+V + + YDL +ENRD T D+VT +A
Sbjct: 1 MSRKIQGGSVVEMQGDEMTRIIWELIKEKLILPYVELDLHSYDLGIENRDATNDQVTKDA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIKK+ VGVKCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 61 AEAIKKYNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYK-SGGVMM 179
VT W KP++IGRHA+GDQY ATD VV PG E+ + P +G + Y V D++ GGV M
Sbjct: 121 VTGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPKDGTQKVTYMVHDFEEGGGVAM 180
Query: 180 GMYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFK 239
GMYN D SI DFA S F+ AL++ WPLYLSTKNTILK YDGRFKDIF E+Y Y+++F+
Sbjct: 181 GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKKYKSQFE 240
Query: 240 TCGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDG 299
I YEHRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDG
Sbjct: 241 AQNICYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDG 300
Query: 300 KTVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLE 359
KTVE EAAHGTVTRHYR YQKG+ETSTNP+ASIFAW+R LAHRA++DNN L F + LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWSRGLAHRAKLDNNTELSFFAKALE 360
Query: 360 DVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
DV I TIEAG MT+DLA CIKG NV R+DYLNT EF+D + + LK + ++K+
Sbjct: 361 DVCIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKAKLAQAKL 414
>ref|XP_860821.1| PREDICTED: similar to Isocitrate dehydrogenase [NADP] cytoplasmic
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) (IDP) isoform 4 [Canis familiaris]
Length = 415
Score = 702 bits (1812), Expect = 0.0, Method: Composition-based stats.
Identities = 271/415 (65%), Positives = 331/415 (79%), Gaps = 2/415 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M++ G +VE+ GDEMTR+IW+ IKE LIFP+V + + YDL +ENRD T D+VT +A
Sbjct: 1 MSQKIRGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIKK+ VGVKCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 61 AEAIKKYNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVY--KVFDYKSGGVM 178
V+ W KP++IGRHA+GDQY ATD VV PG E+ + P++G E Y +V +K GGV
Sbjct: 121 VSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGSEKMTYLIQVLSFKGGGVA 180
Query: 179 MGMYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKF 238
MGMYN D SI DFA S F+ AL++ WPLYLSTKNTILK YDGRFKDIF E+Y Y+++F
Sbjct: 181 MGMYNQDKSIEDFAHSSFQMALSKSWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQF 240
Query: 239 KTCGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPD 298
+ I+YEHRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PD
Sbjct: 241 EAQNIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPD 300
Query: 299 GKTVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRL 358
GKTVE EAAHGTVTRHYR YQKG+ETSTNP+ASIFAWTR LAHRA++DNN L F + L
Sbjct: 301 GKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELSFFAKAL 360
Query: 359 EDVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
E+V + TIEAG MT+DLA CIKG NV R+DYLNT EF+D + + L + + ++K+
Sbjct: 361 EEVCVETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLNIKLAQAKL 415
>ref|NP_034627.3| isocitrate dehydrogenase 1 (NADP+), soluble [Mus musculus]
ref|NP_001104790.1| isocitrate dehydrogenase 1 (NADP+), soluble [Mus musculus]
dbj|BAE36075.1| unnamed protein product [Mus musculus]
dbj|BAE30207.1| unnamed protein product [Mus musculus]
dbj|BAE39299.1| unnamed protein product [Mus musculus]
dbj|BAE34873.1| unnamed protein product [Mus musculus]
dbj|BAE28720.1| unnamed protein product [Mus musculus]
gb|EDL00223.1| isocitrate dehydrogenase 1 (NADP+), soluble, isoform CRA_a [Mus
musculus]
gb|EDL00225.1| isocitrate dehydrogenase 1 (NADP+), soluble, isoform CRA_a [Mus
musculus]
Length = 414
Score = 702 bits (1812), Expect = 0.0, Method: Composition-based stats.
Identities = 272/414 (65%), Positives = 328/414 (79%), Gaps = 1/414 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M++ G +VE+ GDEMTR+IW+ IKE LI P+V + + YDL +ENRD T D+VT +A
Sbjct: 1 MSRKIQGGSVVEMQGDEMTRIIWELIKEKLILPYVELDLHSYDLGIENRDATNDQVTKDA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIKK+ VGVKCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 61 AEAIKKYNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYK-SGGVMM 179
VT W KP++IGRHA+GDQY ATD VV PG E+ + P +G + Y V D++ GGV M
Sbjct: 121 VTGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPKDGTQKVTYMVHDFEEGGGVAM 180
Query: 180 GMYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFK 239
GMYN D SI DFA S F+ AL++ WPLYLSTKNTILK YDGRFKDIF E+Y Y+++F+
Sbjct: 181 GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKKYKSQFE 240
Query: 240 TCGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDG 299
I YEHRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDG
Sbjct: 241 AQKICYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDG 300
Query: 300 KTVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLE 359
KTVE EAAHGTVTRHYR YQKG+ETSTNP+ASIFAW+R LAHRA++DNN L F + LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWSRGLAHRAKLDNNTELSFFAKALE 360
Query: 360 DVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
DV I TIEAG MT+DLA CIKG NV R+DYLNT EF+D + + LK + ++K+
Sbjct: 361 DVCIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKAKLAQAKL 414
>emb|CAH89719.1| hypothetical protein [Pongo abelii]
Length = 414
Score = 702 bits (1812), Expect = 0.0, Method: Composition-based stats.
Identities = 271/414 (65%), Positives = 332/414 (80%), Gaps = 1/414 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M+K + G +VE+ GDEMTR+IW++IKE LIFP+V + + YDL +ENRD T D+VT +A
Sbjct: 1 MSKKISGGSVVEMQGDEMTRIIWEQIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIKK+ VGVKCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 61 AEAIKKYNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYK-SGGVMM 179
V+ W KP++IGRHA+GDQY ATD VV PG E+ + P++G + Y V +++ GGV M
Sbjct: 121 VSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAM 180
Query: 180 GMYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFK 239
GMYN D SI DFA S F+ AL++ WPLYLSTKNTILK YDGRFKDIF E+Y Y+++F+
Sbjct: 181 GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE 240
Query: 240 TCGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDG 299
I+YEHRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDG
Sbjct: 241 ARKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG 300
Query: 300 KTVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLE 359
KTVE EAAHGTVTRHYR YQKG+ETSTNP+ASIFAWTR LAHRA++DNN L F LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALE 360
Query: 360 DVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSKV 413
+V + TIEAG MT+DLA CIKG NV R+DYLNT EF+D + + LK+ + +K+
Sbjct: 361 EVSVETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLALAKL 414
>dbj|BAC39792.1| unnamed protein product [Mus musculus]
Length = 422
Score = 701 bits (1811), Expect = 0.0, Method: Composition-based stats.
Identities = 271/413 (65%), Positives = 327/413 (79%), Gaps = 1/413 (0%)
Query: 1 MNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRVTVEA 60
M++ G +VE+ GDEMTR+IW+ IKE LI P+V + + YDL +ENRD T D+VT +A
Sbjct: 1 MSRKIQGGSVVEMQGDEMTRIIWELIKEKLILPYVELDLHSYDLGIENRDATNDQVTKDA 60
Query: 61 AYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGTVFREPIICSNVPRL 120
A AIKK+ VGVKCATITPDE RV+EF LK+MW+SPNGTIR ILGGTVFRE IIC N+PRL
Sbjct: 61 AEAIKKYNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 121 VTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRFIPANGGEPKVYKVFDYK-SGGVMM 179
VT W KP++IGRHA+GDQY ATD VV PG E+ + P +G + Y V D++ GGV M
Sbjct: 121 VTGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPKDGTQKVTYMVHDFEEGGGVAM 180
Query: 180 GMYNTDDSIRDFARSCFEFALARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFK 239
GMYN D SI DFA S F+ AL++ WPLYLSTKNTILK YDGRFKDIF E+Y Y+++F+
Sbjct: 181 GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKKYKSQFE 240
Query: 240 TCGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDG 299
I YEHRLIDDMVA M+SEGG++WACKNYDGDVQSDS+AQG+GSLGMMTS+L+ PDG
Sbjct: 241 AQKICYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDG 300
Query: 300 KTVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQRLE 359
KTVE EAAHGTVTRHYR YQKG+ETSTNP+ASIFAW+R LAHRA++DNN L F + LE
Sbjct: 301 KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWSRGLAHRAKLDNNTELSFFAKALE 360
Query: 360 DVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKVAMQKSK 412
DV I TIEAG MT+DLA CIKG NV R+DYLNT EF+D + + LK + +++
Sbjct: 361 DVCIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKAKLAQAQ 413
Database: All non-redundant GenBank CDS
translations+PDB+SwissProt+PIR+PRF excluding environmental samples
from WGS projects
Posted date: May 23, 2008 5:56 PM
Number of letters in database: 883,778,997
Number of sequences in database: 2,617,685
Database: /host/Blast/data/nr_perl/nr.01
Posted date: May 23, 2008 5:54 PM
Number of letters in database: 976,759,346
Number of sequences in database: 2,761,413
Database: /host/Blast/data/nr_perl/nr.02
Posted date: May 23, 2008 5:48 PM
Number of letters in database: 374,670,760
Number of sequences in database: 1,165,270
Database: /host/Blast/data/nr_perl/nr.03
Posted date: Apr 28, 2009 5:40 PM
Number of letters in database: 114,943,120
Number of sequences in database: 354,819
Lambda K H
0.315 0.171 0.507
Lambda K H
0.267 0.0521 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 7,407,878,219
Number of Sequences: 6899187
Number of extensions: 408210789
Number of successful extensions: 893070
Number of sequences better than 10.0: 300
Number of HSP's better than 10.0 without gapping: 7000
Number of HSP's successfully gapped in prelim test: 1416
Number of HSP's that attempted gapping in prelim test: 849619
Number of HSP's gapped (non-prelim): 9326
length of query: 413
length of database: 2,350,152,223
effective HSP length: 137
effective length of query: 276
effective length of database: 1,404,963,604
effective search space: 387769954704
effective search space used: 387769954704
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.2 bits)
S2: 81 (35.5 bits)