BLASTP 2.2.17 [Aug-26-2007]
Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Reference for composition-based statistics:
Schäffer, Alejandro A., L. Aravind, Thomas L. Madden,
Schaffer, Alejandro A., L. Aravind, Thomas L. Madden,
Sergei Shavirin, John L. Spouge, Yuri I. Wolf,
Eugene V. Koonin, and Stephen F. Altschul (2001),
"Improving the accuracy of PSI-BLAST protein database searches with
composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005.
Query= YLR389C__[Saccharomyces_cerevisiae]
(1027 letters)
Database: All non-redundant GenBank CDS
translations+PDB+SwissProt+PIR+PRF excluding environmental samples
from WGS projects
6,899,187 sequences; 2,350,152,223 total letters
Searching..................................................done
Results from round 1
Score E
Sequences producing significant alignments: (bits) Value
ref|NP_013493.2| Metalloprotease involved, with homolog Axl... 2041 0.0
gb|EDN59292.1| metalloprotease [Saccharomyces cerevisiae YJ... 2031 0.0
ref|XP_001646584.1| hypothetical protein Kpol_1055p83 [Vand... 1372 0.0
ref|XP_447076.1| unnamed protein product [Candida glabrata]... 1364 0.0
ref|NP_984913.1| AER053Cp [Ashbya gossypii ATCC 10895] >gi|... 1197 0.0
ref|XP_454175.1| unnamed protein product [Kluyveromyces lac... 1187 0.0
ref|XP_505854.1| hypothetical protein [Yarrowia lipolytica]... 803 0.0
ref|XP_719241.1| a-factor pheromone maturation protease [Ca... 763 0.0
ref|XP_001524140.1| conserved hypothetical protein [Loddero... 748 0.0
ref|XP_001397499.1| hypothetical protein An16g01860 [Asperg... 735 0.0
ref|XP_001486793.1| hypothetical protein PGUG_00170 [Pichia... 731 0.0
gb|EDU43925.1| insulin-degrading enzyme [Pyrenophora tritic... 728 0.0
ref|XP_456547.1| hypothetical protein DEHA0A05214g [Debaryo... 724 0.0
ref|XP_001383768.2| hypothetical protein PICST_56651 [Pichi... 723 0.0
ref|XP_001276340.1| a-pheromone processing metallopeptidase... 719 0.0
ref|XP_759404.1| hypothetical protein UM03257.1 [Ustilago m... 718 0.0
ref|XP_748141.1| a-pheromone processing metallopeptidase St... 715 0.0
gb|EDP51051.1| a-pheromone processing metallopeptidase Ste2... 715 0.0
ref|XP_001242515.1| hypothetical protein CIMG_06411 [Coccid... 714 0.0
ref|XP_001801272.1| hypothetical protein SNOG_11020 [Phaeos... 714 0.0
ref|XP_001266332.1| a-pheromone processing metallopeptidase... 714 0.0
ref|XP_001506502.1| PREDICTED: similar to insulin-degrading... 714 0.0
ref|XP_681313.1| hypothetical protein AN8044.2 [Aspergillus... 713 0.0
ref|XP_001501085.1| PREDICTED: similar to insulin-degrading... 710 0.0
ref|XP_360292.2| hypothetical protein MGG_13149 [Magnaporth... 710 0.0
ref|NP_001082994.1| insulin-degrading enzyme [Danio rerio] ... 707 0.0
dbj|BAF62161.1| insulin-degrading enzyme [Danio rerio] 706 0.0
ref|NP_112419.2| insulin degrading enzyme [Mus musculus] >g... 705 0.0
gb|EDL41785.1| insulin degrading enzyme [Mus musculus] 704 0.0
ref|NP_037291.1| insulin degrading enzyme [Rattus norvegicu... 703 0.0
ref|NP_004960.2| insulysin [Homo sapiens] >gi|55959215|emb|... 702 0.0
ref|XP_507922.2| PREDICTED: insulysin isoform 4 [Pan troglo... 702 0.0
ref|NP_001069317.1| insulin-degrading enzyme [Bos taurus] >... 701 0.0
ref|XP_001146520.1| PREDICTED: insulysin isoform 2 [Pan tro... 701 0.0
pdb|2G47|A Chain A, Crystal Structure Of Human Insulin-Degr... 701 0.0
pdb|2JG4|A Chain A, Substrate-Free Ide Structure In Its Clo... 701 0.0
ref|XP_001090249.1| PREDICTED: insulysin isoform 3 [Macaca ... 700 0.0
ref|XP_001090137.1| PREDICTED: insulysin isoform 2 [Macaca ... 700 0.0
sp|Q9JHR7|IDE_MOUSE Insulin-degrading enzyme (Insulysin) (I... 699 0.0
ref|XP_001820380.1| hypothetical protein [Aspergillus oryza... 698 0.0
ref|XP_001146582.1| PREDICTED: insulysin isoform 3 [Pan tro... 694 0.0
pdb|2WBY|A Chain A, Crystal Structure Of Human Insulin-Degr... 688 0.0
ref|XP_956166.1| hypothetical protein NCU00481 [Neurospora ... 688 0.0
gb|ABH09708.1| STE23-like protein [Penicillium marneffei] 686 0.0
sp|P14735|IDE_HUMAN Insulin-degrading enzyme (Insulysin) (I... 682 0.0
ref|XP_001603463.1| PREDICTED: similar to metalloprotease [... 679 0.0
ref|XP_971897.1| PREDICTED: similar to Insulin-degrading en... 679 0.0
ref|XP_001731164.1| hypothetical protein MGL_1347 [Malassez... 678 0.0
ref|XP_001590112.1| hypothetical protein SS1G_08876 [Sclero... 673 0.0
ref|XP_534963.2| PREDICTED: similar to Insulin-degrading en... 672 0.0
gb|EEH33611.1| A-factor-processing enzyme [Paracoccidioides... 666 0.0
ref|XP_001391726.1| hypothetical protein An07g06490 [Asperg... 659 0.0
ref|XP_001218442.1| hypothetical protein ATEG_09820 [Asperg... 653 0.0
ref|XP_001847597.1| metalloprotease [Culex pipiens quinquef... 653 0.0
gb|AAO74689.1| RE17458p [Drosophila melanogaster] 650 0.0
gb|EEH46323.1| insulin-degrading enzyme [Paracoccidioides b... 649 0.0
ref|XP_001661876.1| metalloprotease [Aedes aegypti] >gi|108... 648 0.0
ref|NP_524182.2| Insulin degrading metalloproteinase CG5517... 647 0.0
sp|P22817|IDE_DROME Insulin-degrading enzyme (Insulysin) (I... 645 0.0
ref|NP_593966.1| metallopeptidase [Schizosaccharomyces pomb... 645 0.0
gb|AAA28439.1| insulin-degrading enzyme 639 0.0
ref|XP_387087.1| hypothetical protein FG06911.1 [Gibberella... 639 0.0
ref|XP_001629798.1| predicted protein [Nematostella vectens... 638 0.0
ref|XP_001908020.1| unnamed protein product [Podospora anse... 636 e-180
ref|XP_311589.4| AGAP010351-PA [Anopheles gambiae str. PEST... 625 e-177
ref|XP_001354132.1| GA18943-PA [Drosophila pseudoobscura] >... 622 e-176
ref|XP_773498.1| hypothetical protein CNBI1120 [Cryptococcu... 599 e-169
ref|XP_568105.1| insulin degrading enzyme [Cryptococcus neo... 598 e-169
ref|XP_001770543.1| predicted protein [Physcomitrella paten... 598 e-169
dbj|BAE98754.1| putative zinc protease [Arabidopsis thaliana] 588 e-166
ref|NP_181710.1| peptidase M16 family protein / insulinase ... 586 e-165
emb|CAC67408.1| insulin degrading enzyme [Solanum lycopersi... 581 e-163
ref|NP_001044429.1| Os01g0778800 [Oryza sativa (japonica cu... 578 e-162
ref|XP_001761886.1| predicted protein [Physcomitrella paten... 578 e-162
ref|XP_001543275.1| conserved hypothetical protein [Ajellom... 577 e-162
ref|NP_001060044.1| Os07g0570300 [Oryza sativa (japonica cu... 577 e-162
ref|XP_001896776.1| insulin-degrading enzyme [Brugia malayi... 574 e-161
emb|CAO23586.1| unnamed protein product [Vitis vinifera] 570 e-160
ref|XP_001674236.1| Hypothetical protein CBG09322 [Caenorha... 567 e-159
ref|XP_001194830.1| PREDICTED: similar to Insulin-degrading... 565 e-159
ref|XP_795975.2| PREDICTED: similar to Insulin-degrading en... 564 e-158
ref|XP_001146439.1| PREDICTED: insulysin isoform 1 [Pan tro... 560 e-157
emb|CAO23585.1| unnamed protein product [Vitis vinifera] 560 e-157
ref|NP_741542.1| F44E7.4b [Caenorhabditis elegans] >gi|2128... 560 e-157
ref|XP_001090017.1| PREDICTED: insulysin isoform 1 [Macaca ... 559 e-157
ref|NP_507226.2| Y70C5C.1 [Caenorhabditis elegans] >gi|5808... 552 e-155
dbj|BAC79699.1| putative insulin degrading enzyme [Oryza sa... 552 e-155
ref|NP_741543.1| F44E7.4a [Caenorhabditis elegans] >gi|2291... 551 e-155
ref|XP_001874916.1| predicted protein [Laccaria bicolor S23... 550 e-154
emb|CAB66104.1| protease-like protein [Arabidopsis thaliana] 549 e-154
ref|NP_504514.2| F44E7.4c [Caenorhabditis elegans] >gi|2737... 548 e-154
ref|NP_001023928.1| F44E7.4d [Caenorhabditis elegans] >gi|5... 548 e-153
gb|EAZ04397.1| hypothetical protein OsI_025629 [Oryza sativ... 543 e-152
gb|EAZ40359.1| hypothetical protein OsJ_023842 [Oryza sativ... 543 e-152
gb|EAY76035.1| hypothetical protein OsI_003882 [Oryza sativ... 538 e-150
ref|XP_001833053.1| hypothetical protein CC1G_01115 [Coprin... 535 e-149
ref|XP_001649937.1| metalloprotease [Aedes aegypti] >gi|108... 534 e-149
gb|EAZ04398.1| hypothetical protein OsI_025630 [Oryza sativ... 527 e-147
dbj|BAD52843.1| putative insulin degrading enzyme [Oryza sa... 526 e-147
ref|XP_001760214.1| predicted protein [Physcomitrella paten... 521 e-145
gb|EAY89915.1| hypothetical protein OsI_011148 [Oryza sativ... 517 e-144
ref|NP_001050040.1| Os03g0336300 [Oryza sativa (japonica cu... 516 e-144
gb|EAZ26839.1| hypothetical protein OsJ_010322 [Oryza sativ... 516 e-144
ref|XP_001763915.1| predicted protein [Physcomitrella paten... 513 e-143
ref|NP_504532.1| C02G6.1 [Caenorhabditis elegans] >gi|12801... 511 e-142
gb|EAW50092.1| insulin-degrading enzyme, isoform CRA_b [Hom... 509 e-142
ref|XP_001775609.1| predicted protein [Physcomitrella paten... 508 e-141
ref|NP_172173.2| metalloendopeptidase [Arabidopsis thaliana] 503 e-140
dbj|BAF01167.1| hypothetical protein [Arabidopsis thaliana] 501 e-139
gb|EAZ40360.1| hypothetical protein OsJ_023843 [Oryza sativ... 496 e-138
ref|NP_001118852.1| peptidase M16 family protein / insulina... 493 e-137
emb|CAO21314.1| unnamed protein product [Vitis vinifera] 484 e-134
ref|XP_421686.2| PREDICTED: similar to insulin-degrading en... 483 e-134
ref|YP_436112.1| Secreted/periplasmic Zn-dependent peptidas... 481 e-133
ref|NP_504531.2| C02G6.2 [Caenorhabditis elegans] >gi|33620... 479 e-133
ref|ZP_01866422.1| peptidase, insulinase family protein [Vi... 471 e-130
ref|ZP_01948940.1| peptidase, insulinase family [Vibrio cho... 469 e-130
ref|ZP_01956551.1| peptidase, insulinase family [Vibrio cho... 469 e-130
gb|EDN12518.1| peptidase, insulinase family [Vibrio cholera... 469 e-130
ref|ZP_01482660.1| hypothetical protein VchoR_02001413 [Vib... 468 e-130
ref|ZP_01978745.1| peptidase, insulinase family [Vibrio cho... 468 e-129
gb|EDN15048.1| peptidase, insulinase family [Vibrio cholera... 468 e-129
gb|AAF63132.1|AC011001_2 Putative N-arginine dibasic conver... 467 e-129
ref|NP_231704.1| peptidase, insulinase family [Vibrio chole... 467 e-129
ref|ZP_01478796.1| hypothetical protein VchoM_02002058 [Vib... 467 e-129
ref|ZP_01981574.1| peptidase, insulinase family [Vibrio cho... 466 e-129
ref|ZP_01307403.1| Secreted/periplasmic Zn-dependent peptid... 466 e-129
ref|ZP_01101893.1| protease III precursor [gamma proteobact... 466 e-129
ref|ZP_02135987.1| insulin-degrading enzyme [Vibrio fischer... 465 e-129
gb|EAZ49727.1| peptidase, insulinase family [Vibrio cholera... 464 e-128
ref|ZP_01485575.1| hypothetical protein VchoV5_02001802 [Vi... 464 e-128
ref|ZP_01987074.1| insulin-degrading enzyme [Vibrio harveyi... 464 e-128
ref|YP_205192.1| protease III [Vibrio fischeri ES114] >gi|5... 462 e-128
ref|ZP_01258854.1| peptidase, insulinase family protein [Vi... 462 e-128
ref|ZP_01892098.1| Secreted/periplasmic Zn-dependent peptid... 459 e-127
ref|ZP_01222787.1| putative peptidase, insulinase family pr... 459 e-127
ref|NP_567049.2| peptidase M16 family protein / insulinase ... 459 e-127
ref|XP_001449286.1| hypothetical protein GSPATT00016702001 ... 459 e-127
ref|NP_798585.1| peptidase, insulinase family [Vibrio parah... 458 e-127
ref|NP_935232.1| peptidase, insulinase family [Vibrio vulni... 457 e-126
ref|ZP_01813161.1| peptidase, insulinase family protein [Vi... 456 e-126
ref|NP_760850.1| Peptidase [Vibrio vulnificus CMCP6] >gi|27... 456 e-126
ref|ZP_01235782.1| putative peptidase, insulinase family pr... 455 e-125
ref|ZP_01474320.1| hypothetical protein VEx2w_02003082 [Vib... 454 e-125
ref|ZP_01223918.1| peptidase, insulinase family protein [ma... 454 e-125
ref|YP_129176.1| putative peptidase, insulinase family [Pho... 452 e-125
ref|ZP_02195786.1| peptidase, insulinase family protein [Vi... 452 e-125
ref|ZP_01159983.1| putative peptidase, insulinase family pr... 452 e-125
ref|XP_001434792.1| hypothetical protein GSPATT00006701001 ... 452 e-125
ref|YP_268860.1| zinc metallopeptidase, M16 family [Colwell... 448 e-123
emb|CAF89725.1| unnamed protein product [Tetraodon nigrovir... 447 e-123
ref|ZP_01706404.1| peptidase M16-like [Shewanella putrefaci... 446 e-123
ref|YP_962945.1| peptidase M16 domain protein [Shewanella s... 446 e-123
ref|YP_001141698.1| insulinase [Aeromonas salmonicida subsp... 445 e-123
ref|YP_001446294.1| hypothetical protein VIBHAR_03118 [Vibr... 445 e-123
ref|ZP_00990723.1| peptidase, insulinase family [Vibrio spl... 445 e-122
ref|YP_856528.1| peptidase, insulinase family [Aeromonas hy... 444 e-122
ref|YP_001183975.1| peptidase M16 domain protein [Shewanell... 444 e-122
ref|ZP_01616823.1| Secreted/periplasmic Zn-dependent peptid... 444 e-122
ref|ZP_01064420.1| peptidase, insulinase family protein [Vi... 444 e-122
ref|YP_001502447.1| peptidase M16 domain protein [Shewanell... 441 e-121
ref|YP_733547.1| Insulysin [Shewanella sp. MR-4] >gi|113884... 441 e-121
ref|YP_869105.1| peptidase M16 domain protein [Shewanella s... 440 e-121
ref|YP_001674877.1| peptidase M16 domain protein [Shewanell... 440 e-121
ref|YP_001555276.1| peptidase M16 domain protein [Shewanell... 439 e-121
ref|YP_001761387.1| peptidase M16 domain protein [Shewanell... 437 e-120
ref|YP_737533.1| peptidase M16 domain protein [Shewanella s... 436 e-120
ref|YP_562541.1| peptidase M16-like protein [Shewanella den... 436 e-120
ref|YP_001051112.1| peptidase M16 domain protein [Shewanell... 436 e-120
ref|NP_718646.1| peptidase, M16 family [Shewanella oneidens... 436 e-120
ref|ZP_01168295.1| zinc metallopeptidase, M16 family [Ocean... 435 e-120
ref|YP_001366970.1| peptidase M16 domain protein [Shewanell... 435 e-119
ref|ZP_01844037.1| peptidase M16 domain protein [Shewanella... 434 e-119
ref|ZP_01114527.1| Secreted/periplasmic Zn-dependent peptid... 434 e-119
ref|XP_001031077.1| Insulysin, Insulin-degrading enzyme [Te... 434 e-119
ref|YP_959771.1| peptidase M16 domain protein [Marinobacter... 432 e-119
ref|ZP_02157408.1| peptidase, M16 family protein [Shewanell... 429 e-118
ref|YP_751350.1| peptidase M16 domain protein [Shewanella f... 428 e-117
ref|YP_001473373.1| peptidase M16 domain protein [Shewanell... 426 e-117
ref|XP_001695185.1| insulinase-like metalloprotease [Chlamy... 425 e-116
ref|XP_001024628.2| Insulysin, Insulin-degrading enzyme [Te... 424 e-116
ref|ZP_01736964.1| Secreted/periplasmic Zn-dependent peptid... 422 e-116
ref|YP_001094545.1| peptidase M16 domain protein [Shewanell... 422 e-115
ref|XP_001012179.1| Insulysin, Insulin-degrading enzyme [Te... 419 e-115
emb|CAL51499.1| peptidase M16 family protein / insulinase f... 419 e-115
ref|XP_001623609.1| predicted protein [Nematostella vectens... 418 e-114
ref|XP_001030234.1| Insulysin, Insulin-degrading enzyme [Te... 417 e-114
ref|YP_928038.1| peptidase, M16 family [Shewanella amazonen... 416 e-114
ref|ZP_01135442.1| zinc metallopeptidase, M16 family protei... 414 e-113
ref|XP_001599332.1| PREDICTED: similar to metalloendopeptid... 412 e-113
ref|XP_504079.1| hypothetical protein [Yarrowia lipolytica]... 411 e-112
ref|XP_694205.1| PREDICTED: similar to Nardilysin, N-argini... 409 e-112
ref|XP_001417159.1| predicted protein [Ostreococcus lucimar... 409 e-112
gb|ACO61422.1| predicted protein [Micromonas sp. RCC299] 407 e-111
ref|NP_001038180.2| hypothetical protein LOC557565 [Danio r... 404 e-110
ref|XP_001760921.1| predicted protein [Physcomitrella paten... 404 e-110
ref|XP_001105075.1| PREDICTED: similar to nardilysin (N-arg... 404 e-110
ref|ZP_01680540.1| peptidase, M16 (pitrilysin) family [Vibr... 402 e-110
ref|XP_001140801.1| PREDICTED: nardilysin (N-arginine dibas... 401 e-109
ref|XP_859649.1| PREDICTED: similar to Nardilysin precursor... 400 e-109
ref|XP_001140946.1| PREDICTED: nardilysin (N-arginine dibas... 400 e-109
ref|XP_513403.2| PREDICTED: nardilysin (N-arginine dibasic ... 400 e-109
ref|XP_966800.1| PREDICTED: similar to Nardilysin precursor... 399 e-109
ref|XP_532578.2| PREDICTED: similar to nardilysin (N-argini... 399 e-109
ref|ZP_01896589.1| putative peptidase, insulinase family [M... 399 e-109
sp|O43847|NRDC_HUMAN Nardilysin precursor (N-arginine dibas... 399 e-109
ref|NP_001095132.1| nardilysin (N-arginine dibasic converta... 399 e-109
ref|NP_002516.2| nardilysin (N-arginine dibasic convertase)... 399 e-109
sp|Q5R4H6|NRDC_PONPY Nardilysin precursor (N-arginine dibas... 399 e-109
ref|NP_666262.2| nardilysin, N-arginine dibasic convertase,... 398 e-108
gb|AAH26832.1| Nardilysin, N-arginine dibasic convertase, N... 398 e-108
ref|XP_001491329.1| PREDICTED: similar to nardilysin (N-arg... 398 e-108
emb|CAM16904.1| nardilysin, N-arginine dibasic convertase, ... 398 e-108
ref|XP_001491380.1| PREDICTED: similar to nardilysin (N-arg... 398 e-108
emb|CAA63698.1| NRD1 convertase [Homo sapiens] 397 e-108
ref|XP_001251166.1| PREDICTED: similar to NRD1 protein isof... 397 e-108
ref|XP_001251122.1| PREDICTED: similar to NRD1 protein isof... 397 e-108
gb|AAC39597.1| NRD convertase [Homo sapiens] 397 e-108
gb|EAX06804.1| nardilysin (N-arginine dibasic convertase), ... 397 e-108
gb|EAX06805.1| nardilysin (N-arginine dibasic convertase), ... 397 e-108
ref|XP_001140731.1| PREDICTED: nardilysin (N-arginine dibas... 397 e-108
emb|CAA63694.1| NRD2 convertase [Homo sapiens] 397 e-108
ref|XP_588554.3| PREDICTED: similar to NRD1 protein isoform... 397 e-108
ref|XP_001251077.1| PREDICTED: similar to NRD1 protein isof... 397 e-108
gb|EEH57726.1| predicted protein [Micromonas pusilla CCMP1545] 396 e-108
gb|EAX06808.1| nardilysin (N-arginine dibasic convertase), ... 396 e-108
ref|XP_001362262.1| PREDICTED: similar to nardilysin (N-arg... 396 e-108
ref|XP_001362352.1| PREDICTED: similar to nardilysin (N-arg... 396 e-108
ref|NP_037125.1| n-arginine dibasic convertase 1 [Rattus no... 395 e-108
gb|EDL90380.1| nardilysin, N-arginine dibasic convertase 1 ... 395 e-108
gb|AAH23786.1| Nrd1 protein [Mus musculus] 395 e-108
gb|AAQ63406.1| nardilysin isoform [Homo sapiens] 395 e-108
emb|CAA63696.1| NRD2 convertase [Rattus sp.] 395 e-107
ref|XP_001491355.1| PREDICTED: similar to nardilysin (N-arg... 395 e-107
ref|XP_001491299.1| PREDICTED: similar to nardilysin (N-arg... 395 e-107
ref|NP_001026455.1| nardilysin (N-arginine dibasic converta... 395 e-107
ref|YP_339493.1| peptidase [Pseudoalteromonas haloplanktis ... 392 e-106
ref|XP_001844193.1| nardilysin [Culex pipiens quinquefascia... 386 e-105
ref|ZP_01613408.1| protease III [Alteromonadales bacterium ... 384 e-104
ref|XP_001660612.1| metalloendopeptidase [Aedes aegypti] >g... 382 e-104
ref|XP_001024563.1| insulysin, putative [Tetrahymena thermo... 379 e-103
ref|ZP_03833747.1| protease III precursor [Pectobacterium c... 376 e-102
ref|YP_049101.1| protease III precursor [Erwinia carotovora... 373 e-101
ref|ZP_01042947.1| Secreted Zn-dependent peptidase, insulin... 368 2e-99
ref|ZP_03829109.1| protease III precursor [Pectobacterium c... 365 8e-99
ref|YP_001007484.1| protease III precursor [Yersinia entero... 365 9e-99
ref|XP_624437.2| PREDICTED: similar to Nardilysin precursor... 365 1e-98
gb|AAL15441.1| nardilysin [Homo sapiens] 365 1e-98
ref|XP_001229657.1| hypothetical protein CHGG_03141 [Chaeto... 364 2e-98
ref|NP_404633.1| protease III precursor [Yersinia pestis CO... 363 4e-98
ref|ZP_00834380.1| COG1025: Secreted/periplasmic Zn-depende... 363 4e-98
ref|ZP_01132694.1| putative peptidase [Pseudoalteromonas tu... 363 5e-98
ref|YP_269852.1| zinc metallopeptidase, M16 family [Colwell... 363 6e-98
ref|YP_001719796.1| peptidase M16 domain protein [Yersinia ... 363 6e-98
ref|ZP_00827012.1| COG1025: Secreted/periplasmic Zn-depende... 362 8e-98
ref|YP_156717.1| Secreted Zn-dependent peptidase, insulinas... 360 3e-97
ref|ZP_01043970.1| Zn-dependent peptidase, insulinase famil... 360 3e-97
ref|ZP_01075184.1| peptidase, insulinase family protein [Ma... 358 9e-97
emb|CAO77947.1| nardilysin, N-arginine dibasic convertase, ... 358 1e-96
ref|ZP_00822919.1| COG1025: Secreted/periplasmic Zn-depende... 357 3e-96
ref|YP_001480039.1| peptidase M16 domain protein [Serratia ... 357 3e-96
ref|ZP_00830096.1| COG1025: Secreted/periplasmic Zn-depende... 354 2e-95
ref|XP_001355509.1| GA15192-PA [Drosophila pseudoobscura] >... 352 7e-95
ref|YP_575066.1| peptidase M16-like protein [Chromohalobact... 348 2e-93
ref|YP_155380.1| Zn-dependent peptidase, insulinase family ... 348 2e-93
ref|NP_927976.1| Protease III precursor (pitrilysin) [Photo... 346 6e-93
ref|XP_001454805.1| hypothetical protein GSPATT00021051001 ... 345 2e-92
ref|YP_341835.1| putative TonB-dependent receptor protease/... 342 8e-92
ref|ZP_01625177.1| Secreted Zn-dependent peptidase, insulin... 342 9e-92
ref|NP_649271.1| CG10588 CG10588-PA [Drosophila melanogaste... 342 1e-91
ref|ZP_00713497.1| COG1025: Secreted/periplasmic Zn-depende... 339 7e-91
ref|XP_320119.6| AGAP010315-PA [Anopheles gambiae str. PEST... 339 7e-91
ref|ZP_00920643.1| COG1025: Secreted/periplasmic Zn-depende... 338 1e-90
ref|NP_461912.1| protease III [Salmonella typhimurium LT2] ... 338 1e-90
ref|ZP_02683828.1| protease III [Salmonella enterica subsp.... 338 1e-90
ref|ZP_02999194.1| protease III [Escherichia coli 53638] >g... 338 1e-90
ref|YP_001573574.1| hypothetical protein SARI_04665 [Salmon... 338 1e-90
ref|NP_572757.2| CG2025 CG2025-PA [Drosophila melanogaster]... 338 2e-90
ref|NP_755290.1| Protease III precursor [Escherichia coli C... 338 2e-90
ref|ZP_02343890.1| protease III [Salmonella enterica subsp.... 337 2e-90
ref|YP_542202.1| protease III precursor [Escherichia coli U... 337 3e-90
ref|ZP_00714851.1| COG1025: Secreted/periplasmic Zn-depende... 337 3e-90
ref|ZP_00923440.1| COG1025: Secreted/periplasmic Zn-depende... 337 3e-90
ref|ZP_02349797.1| protease III precursor [Salmonella enter... 337 3e-90
ref|ZP_02560586.1| protease III [Salmonella enterica subsp.... 337 3e-90
ref|YP_001436619.1| hypothetical protein ESA_00488 [Enterob... 337 3e-90
ref|ZP_00712570.1| COG1025: Secreted/periplasmic Zn-depende... 337 3e-90
gb|AAV36919.1| RE02581p [Drosophila melanogaster] 337 4e-90
ref|YP_001744989.1| protease III [Escherichia coli SMS-3-5]... 337 4e-90
ref|ZP_02644586.1| protease III [Salmonella enterica subsp.... 337 4e-90
ref|ZP_03838288.1| hypothetical protein CATC2_19978 [Citrob... 336 5e-90
ref|NP_001044431.1| Os01g0779100 [Oryza sativa (japonica cu... 336 5e-90
ref|YP_001464156.1| protease III [Escherichia coli E24377A]... 336 6e-90
gb|AAB40468.1| protease III precursor (pitrilysin) 335 1e-89
ref|ZP_01611741.1| putative TonB-dependent receptor proteas... 335 1e-89
ref|NP_417298.1| protease III [Escherichia coli str. K-12 s... 335 1e-89
pdb|1Q2L|A Chain A, Crystal Structure Of Pitrilysin 335 1e-89
ref|NP_495575.2| C28F5.4 [Caenorhabditis elegans] >gi|15038... 335 1e-89
ref|YP_311808.1| protease III [Shigella sonnei Ss046] >gi|7... 335 1e-89
ref|YP_404546.1| protease III [Shigella dysenteriae Sd197] ... 334 2e-89
>ref|NP_013493.2| Metalloprotease involved, with homolog Axl1p, in N-terminal
processing of pro-a-factor to the mature form; member of
the insulin-degrading enzyme family; Ste23p
[Saccharomyces cerevisiae]
sp|Q06010|STE23_YEAST A-factor-processing enzyme
gb|AAB82351.2| Ste23p [Saccharomyces cerevisiae]
Length = 1027
Score = 2041 bits (5287), Expect = 0.0, Method: Composition-based stats.
Identities = 1027/1027 (100%), Positives = 1027/1027 (100%)
Query: 1 MGVSLLASSSAFVTKPLLTQLVHLSPISLNFTVRRFKPFTCLSRYYTTNPYNMTSNFKTF 60
MGVSLLASSSAFVTKPLLTQLVHLSPISLNFTVRRFKPFTCLSRYYTTNPYNMTSNFKTF
Sbjct: 1 MGVSLLASSSAFVTKPLLTQLVHLSPISLNFTVRRFKPFTCLSRYYTTNPYNMTSNFKTF 60
Query: 61 NLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNLPGLAHFC 120
NLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNLPGLAHFC
Sbjct: 61 NLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNLPGLAHFC 120
Query: 121 EHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGALDRFSGFFS 180
EHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGALDRFSGFFS
Sbjct: 121 EHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGALDRFSGFFS 180
Query: 181 CPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGTLP 240
CPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGTLP
Sbjct: 181 CPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGTLP 240
Query: 241 KENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGREVPLYAE 300
KENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGREVPLYAE
Sbjct: 241 KENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGREVPLYAE 300
Query: 301 PIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGSGSLLAHL 360
PIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGSGSLLAHL
Sbjct: 301 PIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGSGSLLAHL 360
Query: 361 KKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLPQKWI 420
KKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLPQKWI
Sbjct: 361 KKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLPQKWI 420
Query: 421 FNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILAMGLLTKYEPDLLTQYTD 480
FNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILAMGLLTKYEPDLLTQYTD
Sbjct: 421 FNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILAMGLLTKYEPDLLTQYTD 480
Query: 481 ALVPENSRVTLISRSLETDSAEKWYGTAYKVVDYPADLIKNMKSPGLNPALTLPRPNEFV 540
ALVPENSRVTLISRSLETDSAEKWYGTAYKVVDYPADLIKNMKSPGLNPALTLPRPNEFV
Sbjct: 481 ALVPENSRVTLISRSLETDSAEKWYGTAYKVVDYPADLIKNMKSPGLNPALTLPRPNEFV 540
Query: 541 STNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLPHTHASIINS 600
STNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLPHTHASIINS
Sbjct: 541 STNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLPHTHASIINS 600
Query: 601 MLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLIILLTRFLQGVN 660
MLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLIILLTRFLQGVN
Sbjct: 601 MLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLIILLTRFLQGVN 660
Query: 661 SFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKLQVFEKLTFE 720
SFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKLQVFEKLTFE
Sbjct: 661 SFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKLQVFEKLTFE 720
Query: 721 QLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIHNLQVSNNRLRSYLLPK 780
QLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIHNLQVSNNRLRSYLLPK
Sbjct: 721 QLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIHNLQVSNNRLRSYLLPK 780
Query: 781 GKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFAQLIHEPCFDTLRTKEQLGY 840
GKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFAQLIHEPCFDTLRTKEQLGY
Sbjct: 781 GKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFAQLIHEPCFDTLRTKEQLGY 840
Query: 841 VVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVLRDMPEEDFEKHKEALCN 900
VVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVLRDMPEEDFEKHKEALCN
Sbjct: 841 VVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVLRDMPEEDFEKHKEALCN 900
Query: 901 SLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMIDFYENYIMSENASK 960
SLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMIDFYENYIMSENASK
Sbjct: 901 SLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMIDFYENYIMSENASK 960
Query: 961 LILHLKSQVENKELNENELDTAKYPTGQLIEDVGAFKSTLFVAPVRQPMKDFEISAPPKL 1020
LILHLKSQVENKELNENELDTAKYPTGQLIEDVGAFKSTLFVAPVRQPMKDFEISAPPKL
Sbjct: 961 LILHLKSQVENKELNENELDTAKYPTGQLIEDVGAFKSTLFVAPVRQPMKDFEISAPPKL 1020
Query: 1021 NNSSESE 1027
NNSSESE
Sbjct: 1021 NNSSESE 1027
>gb|EDN59292.1| metalloprotease [Saccharomyces cerevisiae YJM789]
Length = 1027
Score = 2031 bits (5262), Expect = 0.0, Method: Composition-based stats.
Identities = 1021/1027 (99%), Positives = 1026/1027 (99%)
Query: 1 MGVSLLASSSAFVTKPLLTQLVHLSPISLNFTVRRFKPFTCLSRYYTTNPYNMTSNFKTF 60
MGVSLLASSSAFVTKPLLTQLVH SPISLNFTVRRFKPFTCLSRYYTTNPYNMTSNFKTF
Sbjct: 1 MGVSLLASSSAFVTKPLLTQLVHFSPISLNFTVRRFKPFTCLSRYYTTNPYNMTSNFKTF 60
Query: 61 NLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNLPGLAHFC 120
NLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDP+NLPGLAHFC
Sbjct: 61 NLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPENLPGLAHFC 120
Query: 121 EHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGALDRFSGFFS 180
EHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGALDRFSGFFS
Sbjct: 121 EHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGALDRFSGFFS 180
Query: 181 CPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGTLP 240
CPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGTLP
Sbjct: 181 CPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGTLP 240
Query: 241 KENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGREVPLYAE 300
KENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLS+WTYDLFKDVANNGREVPLYAE
Sbjct: 241 KENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSNWTYDLFKDVANNGREVPLYAE 300
Query: 301 PIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGSGSLLAHL 360
PIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGSGSLLAHL
Sbjct: 301 PIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGSGSLLAHL 360
Query: 361 KKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLPQKWI 420
KKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLPQKWI
Sbjct: 361 KKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLPQKWI 420
Query: 421 FNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILAMGLLTKYEPDLLTQYTD 480
FNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILAMGLLTKYEPDLLTQYTD
Sbjct: 421 FNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILAMGLLTKYEPDLLTQYTD 480
Query: 481 ALVPENSRVTLISRSLETDSAEKWYGTAYKVVDYPADLIKNMKSPGLNPALTLPRPNEFV 540
ALVPENSRVTLISRSLETDSAEKWYGTAYKVVDYPADLIKNMKSPGLNPALTLPRPNEFV
Sbjct: 481 ALVPENSRVTLISRSLETDSAEKWYGTAYKVVDYPADLIKNMKSPGLNPALTLPRPNEFV 540
Query: 541 STNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLPHTHASIINS 600
STNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLPHTHASIINS
Sbjct: 541 STNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLPHTHASIINS 600
Query: 601 MLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLIILLTRFLQGVN 660
MLSTLYTQLANDALKD+QYDAACADLRISFNKTNQGLAITASGFNEKLIILLTRFLQGVN
Sbjct: 601 MLSTLYTQLANDALKDLQYDAACADLRISFNKTNQGLAITASGFNEKLIILLTRFLQGVN 660
Query: 661 SFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKLQVFEKLTFE 720
SFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKLQVFEKLTFE
Sbjct: 661 SFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKLQVFEKLTFE 720
Query: 721 QLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIHNLQVSNNRLRSYLLPK 780
QLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIHNLQVSNNRLRSYLLPK
Sbjct: 721 QLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIHNLQVSNNRLRSYLLPK 780
Query: 781 GKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFAQLIHEPCFDTLRTKEQLGY 840
GKTFRYETALKDS+NVNSCIQHVTQLDVYSEDLSALSGLFAQLIHEPCFDTLRTKEQLGY
Sbjct: 781 GKTFRYETALKDSRNVNSCIQHVTQLDVYSEDLSALSGLFAQLIHEPCFDTLRTKEQLGY 840
Query: 841 VVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVLRDMPEEDFEKHKEALCN 900
VVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVLRDMPEEDFEKHKEALCN
Sbjct: 841 VVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVLRDMPEEDFEKHKEALCN 900
Query: 901 SLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMIDFYENYIMSENASK 960
SLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMIDFYENYIMSENASK
Sbjct: 901 SLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMIDFYENYIMSENASK 960
Query: 961 LILHLKSQVENKELNENELDTAKYPTGQLIEDVGAFKSTLFVAPVRQPMKDFEISAPPKL 1020
LILHLKSQVENKELNENELDTAKYPTGQLIEDVGAFKSTLFVAPVRQPMKDFEISAPPKL
Sbjct: 961 LILHLKSQVENKELNENELDTAKYPTGQLIEDVGAFKSTLFVAPVRQPMKDFEISAPPKL 1020
Query: 1021 NNSSESE 1027
NNSSES+
Sbjct: 1021 NNSSESD 1027
>ref|XP_001646584.1| hypothetical protein Kpol_1055p83 [Vanderwaltozyma polyspora DSM
70294]
gb|EDO18726.1| hypothetical protein Kpol_1055p83 [Vanderwaltozyma polyspora DSM
70294]
Length = 1020
Score = 1372 bits (3550), Expect = 0.0, Method: Composition-based stats.
Identities = 658/992 (66%), Positives = 833/992 (83%), Gaps = 2/992 (0%)
Query: 28 SLNFTVRRFKPFTCLSRYYTTNPYNMTSNFKTFNLDFLKPDLDERSYRFIELPNKLKALL 87
S+ +R F R +T +K +L+F+KPDLD+RSYRFIELPNK KALL
Sbjct: 29 SIPLYLRNFTKINYYKRKMSTTSDVTKKPYKIHDLNFIKPDLDDRSYRFIELPNKFKALL 88
Query: 88 IQDPKADKAAASLDVNIGAFEDPKNLPGLAHFCEHLLFMGSEKFPDENEYSSYLSKHGGS 147
I D DK+AASLDVNIGAF+DPKNL GLAHFCEHLLFMGS+KFP+ENEYSSYL+KHGGS
Sbjct: 89 IHDASTDKSAASLDVNIGAFQDPKNLQGLAHFCEHLLFMGSKKFPNENEYSSYLNKHGGS 148
Query: 148 SNAYTASQNTNYFFEVNHQHLFGALDRFSGFFSCPLFNKDSTDKEINAVNSENKKNLQND 207
SNAYT +QNTNYFFE+NH+HL GALDRFSGFF+CPLFN +ST KEINAV+SENKKNLQND
Sbjct: 149 SNAYTGAQNTNYFFEINHEHLHGALDRFSGFFTCPLFNPNSTSKEINAVDSENKKNLQND 208
Query: 208 IWRIYQLDKSLTNTKHPYHKFSTGNIETLGTLPKENGLNVRDELLKFHKNFYSANLMKLC 267
+WR+YQLDKSL+N KHPYHKFSTGN++TL +PK+ GL++R+ELLKF+ + YSANLMKLC
Sbjct: 209 VWRMYQLDKSLSNEKHPYHKFSTGNLKTLDEMPKKEGLDIRNELLKFYSDSYSANLMKLC 268
Query: 268 ILGREDLDTLSDWTYDLFKDVANNGREVPLYAEPIMQPEHLQKIIQVRPVKDLKKLEISF 327
+LGREDLDT+SDW Y+LF+ V NN R +P Y EPI+ E+L+KII V+PVKDLKKLEI+F
Sbjct: 269 VLGREDLDTMSDWVYNLFEAVPNNNRPLPEYNEPILLEENLKKIIHVKPVKDLKKLEITF 328
Query: 328 TVPDMEEHWESKPPRILSHLIGHEGSGSLLAHLKKLGWANELSAGGHTVSKGNAFFAVDI 387
DM+ WESKP ILSHLIGHEGSGS+L+HLK L WANELSAGGHTVSK NAFF++DI
Sbjct: 329 LAQDMDLFWESKPQHILSHLIGHEGSGSILSHLKTLSWANELSAGGHTVSKDNAFFSIDI 388
Query: 388 DLTDNGLTHYRDVIVLIFQYIEMLKNSLPQKWIFNELQDISNATFKFKQAGSPSSTVSSL 447
DLT+NG HY++++ ++FQYIEMLK SLPQ+ IF ELQDI+NA+FKFKQ +PSSTVS+L
Sbjct: 389 DLTENGFQHYKEIVHIVFQYIEMLKISLPQERIFLELQDIANASFKFKQKVNPSSTVSNL 448
Query: 448 AKCLEKDYIPVSRILAMGLLTKYEPDLLTQYTDALVPENSRVTLISRSLETDSAEKWYGT 507
+K LEK+YIPV IL+ GL KY+P+++ Y ++L P+NSR+TL +++ETDS E WYGT
Sbjct: 449 SKALEKEYIPVENILSTGLFRKYDPEIMKNYVNSLSPDNSRITLAGKAVETDSKETWYGT 508
Query: 508 AYKVVDYPADLIKNMKSPGLNPALTLPRPNEFVSTNFKVDKIDGIKPLDEPVLLLSDDVS 567
Y+V DYP DL +KSPGLNP L++PRPNEF++TNF V+K D +PL EP+LL VS
Sbjct: 509 DYRVEDYPKDLYDTIKSPGLNPNLSIPRPNEFIATNFDVEKFDVNEPLVEPLLLKDSPVS 568
Query: 568 KLWYKKDDRFWQPRGYIYLSFKLPHTHASIINSMLSTLYTQLANDALKDVQYDAACADLR 627
KLWYKKDDRFWQPRG+IY++ KLPHT AS+IN++L++LY QL ND+LKD+QYDAACA+L
Sbjct: 569 KLWYKKDDRFWQPRGFIYITMKLPHTQASVINNLLTSLYVQLVNDSLKDLQYDAACANLH 628
Query: 628 ISFNKTNQGLAITASGFNEKLIILLTRFLQGVNSFEPKKDRFEILKDKTIRHLKNLLYEV 687
+SF+KTNQGL IT SGFN+KLI+LL RF+ GV+ ++P K RF+I K+KTI++LKN LYEV
Sbjct: 629 LSFSKTNQGLDITISGFNDKLIVLLQRFIYGVSVYQPSKLRFKIFKEKTIQNLKNCLYEV 688
Query: 688 PYSQMSNYYNAIINERSWSTAEKLQVFEKLTFEQLINFIPTIYEGVYFETLIHGNIKHEE 747
PYSQ+S Y+++INER+WS +KL + EK+T+EQ + F+PTIYE YF+ L+HGN ++EE
Sbjct: 689 PYSQISTLYSSLINERTWSVKQKLSIIEKITYEQFLAFLPTIYEECYFDGLVHGNFRNEE 748
Query: 748 ALEVDSLIKSLIPNNIHNLQVSNNRLRSYLLPKGKTFRYETALKDSQNVNSCIQHVTQLD 807
A+E+DSL++SLI +I NL V N RLRSY++P G+T+R+E L+D++NVNSC+QHV QL
Sbjct: 749 AVEIDSLVQSLITTDIVNLHVKNTRLRSYVIPNGETYRFEIDLEDAENVNSCVQHVVQLG 808
Query: 808 VYSEDLSALSGLFAQLIHEPCFDTLRTKEQLGYVVFSSSLNNHGTANIRILIQSEHTTPY 867
YSE+LSA+SGLFAQ+++EPCFDTLRTKEQLGYVVFSSSLNNHGTANIRIL+QSEH+TPY
Sbjct: 809 GYSEELSAMSGLFAQILNEPCFDTLRTKEQLGYVVFSSSLNNHGTANIRILVQSEHSTPY 868
Query: 868 LEWRINNFYETFGQVLRDMPEEDFEKHKEALCNSLLQKFKNMAEESARYTAAIYLGDYNF 927
LEWRI+ FY++FG+ LR+M +++ EKHK+ALC SL+QK+KNM EE++RYTAAIYLGDYNF
Sbjct: 869 LEWRIDEFYKSFGETLRNMSDDELEKHKDALCKSLMQKYKNMKEENSRYTAAIYLGDYNF 928
Query: 928 THRQKKAKLVANITKQQMIDFYENYIMSENASKLILHLKSQVE--NKELNENELDTAKYP 985
THRQKKA LVA I+K Q+I F+E++ +S NA+KL++HLKS+V+ +K++NE++LD KYP
Sbjct: 929 THRQKKANLVAQISKDQLIKFFEDHFISANAAKLVIHLKSKVKSSDKDINEDKLDVKKYP 988
Query: 986 TGQLIEDVGAFKSTLFVAPVRQPMKDFEISAP 1017
TG+LI DV FKS L+ AP+RQP+K F++ P
Sbjct: 989 TGKLITDVDEFKSKLYAAPIRQPLKKFDVYKP 1020
>ref|XP_447076.1| unnamed protein product [Candida glabrata]
emb|CAG60009.1| unnamed protein product [Candida glabrata CBS 138]
Length = 1008
Score = 1364 bits (3530), Expect = 0.0, Method: Composition-based stats.
Identities = 684/989 (69%), Positives = 824/989 (83%), Gaps = 8/989 (0%)
Query: 33 VRRFKPFTCLSRYYTTNPYNMTSN-----FKTFNLDFLKPDLDERSYRFIELPNKLKALL 87
VR F L+ YY Y +N +K + FLKPDLD+R YR+I+LPN LKAL+
Sbjct: 17 VRIALQFKKLTSYYYKKNYTTVANKSTMPYKDLKVQFLKPDLDDRQYRYIQLPNNLKALI 76
Query: 88 IQDPKADKAAASLDVNIGAFEDPKNLPGLAHFCEHLLFMGSEKFPDENEYSSYLSKHGGS 147
IQD DKAAA+LDVNIGAF+DP+NLPGLAHFCEHLLFMGSEKFPDENEYSSYLSKHGGS
Sbjct: 77 IQDATTDKAAAALDVNIGAFQDPENLPGLAHFCEHLLFMGSEKFPDENEYSSYLSKHGGS 136
Query: 148 SNAYTASQNTNYFFEVNHQHLFGALDRFSGFFSCPLFNKDSTDKEINAVNSENKKNLQND 207
SNAYT SQNTNYFFEVN HL GALDRFSGFFSCPLFN++STDKEINAV+SENKKNLQND
Sbjct: 137 SNAYTGSQNTNYFFEVNADHLHGALDRFSGFFSCPLFNQNSTDKEINAVDSENKKNLQND 196
Query: 208 IWRIYQLDKSLTNTKHPYHKFSTGNIETLGTLPKENGLNVRDELLKFHKNFYSANLMKLC 267
IWR+YQLDKSL+N HPYHKFSTGN+ETLG PK GL++R+ELLKF+ YSANLMKLC
Sbjct: 197 IWRMYQLDKSLSNQDHPYHKFSTGNLETLGDKPKAAGLDIREELLKFYNENYSANLMKLC 256
Query: 268 ILGREDLDTLSDWTYDLFKDVANNGREVPLYAEPIMQPEHLQKIIQVRPVKDLKKLEISF 327
ILG+EDLDTLS+W ++LFKDV N+ R +P+Y PI++ L+KII+V+PVKDL+KL+ISF
Sbjct: 257 ILGKEDLDTLSEWAWELFKDVKNSDRALPVYDAPILKENDLKKIIKVKPVKDLRKLDISF 316
Query: 328 TVPDMEEHWESKPPRILSHLIGHEGSGSLLAHLKKLGWANELSAGGHTVSKGNAFFAVDI 387
VPD E+ WE+K I SHLIGHEGSGSLLAHLK LGWANEL AGGHTVS GNAFF VDI
Sbjct: 317 VVPDYEKKWEAKISHIFSHLIGHEGSGSLLAHLKSLGWANELGAGGHTVSDGNAFFNVDI 376
Query: 388 DLTDNGLTHYRDVIVLIFQYIEMLKNSLPQKWIFNELQDISNATFKFKQAGSPSSTVSSL 447
+LT+ GL HY+D++VLIFQY+EMLK SLPQ+WIF ELQDISNATFKFKQ GS S TVS L
Sbjct: 377 ELTNEGLKHYKDIVVLIFQYLEMLKTSLPQEWIFKELQDISNATFKFKQKGSASQTVSGL 436
Query: 448 AKCLEKD-YIPVSRILAMGLLTKYEPDLLTQYTDALVPENSRVTLISRSLETDSAEKWYG 506
AK LEKD Y PV ILA LL KYEP+L+ + + PENSR+T ISRS+ DS E+WYG
Sbjct: 437 AKQLEKDYYFPVENILATNLLVKYEPELIKHFMKSFTPENSRITFISRSIVADSKEQWYG 496
Query: 507 TAYKVVDYPADLIKNMKSPGLNPALTLPRPNEFVSTNFKVDKIDGIKPLDEPVLLLSDDV 566
T Y V DY + +K++++PGLNP L++PRPNEF++TNF V+K D +PL+EP+LL DDV
Sbjct: 497 TEYSVEDYSPEFLKSIENPGLNPNLSVPRPNEFIATNFDVEKFDVKEPLNEPLLLKDDDV 556
Query: 567 SKLWYKKDDRFWQPRGYIYLSFKLPHTHASIINSMLSTLYTQLANDALKDVQYDAACADL 626
SKLWYKKDDRFWQPRGYIY++ KLP+TH+SII+SML+TLY Q+ NDALKD+QYDAACA++
Sbjct: 557 SKLWYKKDDRFWQPRGYIYVTLKLPNTHSSIISSMLTTLYVQMVNDALKDLQYDAACANI 616
Query: 627 RISFNKTNQGLAITASGFNEKLIILLTRFLQGVNSFEPKKDRFEILKDKTIRHLKNLLYE 686
+SF KTNQGL IT SGFNEKL+ILL RF++GV FEPKK+RFE+ KDKT+ HLKN + E
Sbjct: 617 NLSFVKTNQGLDITISGFNEKLLILLKRFVEGVQGFEPKKERFEVFKDKTVHHLKNQMME 676
Query: 687 VPYSQMSNYYNAIINERSWSTAEKLQVFEKLTFEQLINFIPTIYEGVYFETLIHGNIKHE 746
VPYSQ+S YN+++NER+W T EKL+V EKL FEQL NF+ IY+G+Y+E+ +HGN++ +
Sbjct: 677 VPYSQISGLYNSVVNERTWPTKEKLEVAEKLKFEQLDNFVRAIYDGMYYESFVHGNLESK 736
Query: 747 EALEVDSLIKSLI-PNNIHNLQVSNNRLRSYLLPKGKTFRYETALKDSQNVNSCIQHVTQ 805
EA EVDSL+ + + ++I N+ V +NRLRSY++PKGK++ YET L D NVNSCIQHV Q
Sbjct: 737 EAREVDSLVSTFLKKDDIKNIDVQSNRLRSYIIPKGKSYAYETDLYDENNVNSCIQHVVQ 796
Query: 806 LDVYSEDLSALSGLFAQLIHEPCFDTLRTKEQLGYVVFSSSLNNHGTANIRILIQSEHTT 865
LDVY+E LSALSGLFAQ++HEPCFD LRTKEQLGYVVFSSSLNNHGTANIRIL+QSEHTT
Sbjct: 797 LDVYNEKLSALSGLFAQMLHEPCFDILRTKEQLGYVVFSSSLNNHGTANIRILVQSEHTT 856
Query: 866 PYLEWRINNFYETFGQVLRDMPEEDFEKHKEALCNSLLQKFKNMAEESARYTAAIYLGDY 925
PYLEWRI+ FY+TFG+ LR+M EEDF KHKEALC +LLQKFKNM EES RY AAIYLGDY
Sbjct: 857 PYLEWRIDEFYKTFGEKLRNMDEEDFNKHKEALCKTLLQKFKNMKEESLRYVAAIYLGDY 916
Query: 926 NFTHRQKKAKLVANITKQQMIDFYENYIMSENASKLILHLKSQVENKELNENELDTAKYP 985
N+ HRQKKA +V ++TK+ MI F+ENYI S++A+KL++HLKS+ + E +E++LDT KYP
Sbjct: 917 NYLHRQKKADMVKDLTKEDMIAFFENYIESDDATKLVIHLKSK-KATEKDESQLDTTKYP 975
Query: 986 TGQLIEDVGAFKSTLFVAPVRQPMKDFEI 1014
+G+ IEDVG F+S L++AP+RQP K FEI
Sbjct: 976 SGEKIEDVGQFRSQLYLAPLRQPTKKFEI 1004
>ref|NP_984913.1| AER053Cp [Ashbya gossypii ATCC 10895]
gb|AAS52737.1| AER053Cp [Ashbya gossypii ATCC 10895]
Length = 1013
Score = 1197 bits (3098), Expect = 0.0, Method: Composition-based stats.
Identities = 572/971 (58%), Positives = 742/971 (76%), Gaps = 3/971 (0%)
Query: 48 TNPYNMTSNFKTFNLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAF 107
+N + S + +P LD+R YR+IELPN L+ LL+ D DK+AASLDVN+GAF
Sbjct: 43 SNNISGVSGLRELAATLEQPLLDDRKYRYIELPNHLRVLLVHDKNTDKSAASLDVNVGAF 102
Query: 108 EDPKNLPGLAHFCEHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQH 167
EDP++LPGLAHFCEHLLFMGS+KFP+ENEY+S+LSKHGG+SNAYTASQNTNY+F VNH++
Sbjct: 103 EDPEDLPGLAHFCEHLLFMGSKKFPNENEYASFLSKHGGASNAYTASQNTNYYFHVNHEN 162
Query: 168 LFGALDRFSGFFSCPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHK 227
L+ ALDRFSGFFSCPLFN+ ST+KEI AV+SENKKNLQND+WR+YQL KSLTN HPYHK
Sbjct: 163 LYDALDRFSGFFSCPLFNESSTEKEIKAVDSENKKNLQNDMWRLYQLGKSLTNPIHPYHK 222
Query: 228 FSTGNIETLGTLPKENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKD 287
FSTGN ETL ++P+ G+NVRDELLKF+ YSANLMKL ILGREDLDTL+ W Y+LFKD
Sbjct: 223 FSTGNFETLWSIPRSKGVNVRDELLKFYNRSYSANLMKLVILGREDLDTLAQWAYELFKD 282
Query: 288 VANNGREVPLYAEPIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHL 347
V N+G +VP Y PEHL K+I+V+PVK+LK +EISF VPDM++HW+ KP R LSHL
Sbjct: 283 VPNHGTKVPEYHAQAFTPEHLMKVIKVKPVKNLKSVEISFVVPDMDKHWQVKPARYLSHL 342
Query: 348 IGHEGSGSLLAHLKKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQY 407
IGHEG+ SLLA+LK WA +LSAG TVS+GNA+F+V++DLTD G+ Y VI +FQY
Sbjct: 343 IGHEGTDSLLAYLKNNSWAIDLSAGATTVSEGNAYFSVNVDLTDEGVVQYEAVICAVFQY 402
Query: 408 IEMLKNSLPQKWIFNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILAMGLL 467
I MLK LPQ+W+F EL+DI A FKFKQ G+P++TVSSL+K L+K Y+PV IL L+
Sbjct: 403 INMLKEVLPQEWVFTELKDIGEAHFKFKQKGNPAATVSSLSKNLQKAYLPVQVILNTSLM 462
Query: 468 TKYEPDLLTQYTDALVPENSRVTLISRSLETDSAEKWYGTAYKVVDYPADLIKNMKSPGL 527
+YEP L+ +Y ++L ENSRV LIS+ +ET+ +E+WYGT Y V DY D + ++S G
Sbjct: 463 RQYEPGLIMEYLNSLTLENSRVMLISQKVETNLSERWYGTEYSVADYTKDFVSKIRSLGA 522
Query: 528 NPALTLPRPNEFVSTNFKVDKIDG-IKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYL 586
NPAL +P PNEF++T F V K +G +KPL EP LL D KLWYKKDD FW P+GYIY+
Sbjct: 523 NPALKIPAPNEFIATRFDVHKDEGNVKPLLEPFLLRDDRCGKLWYKKDDMFWVPKGYIYI 582
Query: 587 SFKLPHTHASIINSMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNE 646
S KLPHTH+SI+NSML TLY ND+LKD+ Y+A CA L IS KTNQGL ++ SG+N+
Sbjct: 583 SMKLPHTHSSIVNSMLCTLYVDHINDSLKDLAYNAECAGLEISLRKTNQGLDLSLSGYND 642
Query: 647 KLIILLTRFLQGVNSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWS 706
KL++LL RF +G+ +++RF +LK + I+ L N LY+ PY+Q+ Y+++INERSW+
Sbjct: 643 KLLVLLARFFEGIQKLFLREERFMVLKQRLIQKLHNHLYDTPYTQIGRLYSSLINERSWT 702
Query: 707 TAEKLQVFEKLTFEQLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIHNL 766
T EKL + E+LTF+ L NF+PTIYE +YFE L+HGN HEEALEV L+ SL+PN I N
Sbjct: 703 TQEKLDITEQLTFDHLANFVPTIYEQMYFELLVHGNFSHEEALEVYDLVSSLVPNEIRNS 762
Query: 767 QVSNNRLRSYLLPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFAQLIHE 826
+ N++LRSY +P G + YETAL D +NVNSCIQ V QL YSE LSA L AQ+++E
Sbjct: 763 EGRNSKLRSYFIPAGGAYHYETALADKENVNSCIQKVIQLGAYSELLSAKGSLLAQMVNE 822
Query: 827 PCFDTLRTKEQLGYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVLRDM 886
PCF+TLRT+EQLGYVVFSS LN HGT N+RIL+QSE ++ YLE RI+ + FG L M
Sbjct: 823 PCFNTLRTEEQLGYVVFSSKLNTHGTVNLRILVQSERSSSYLESRIDTSCQKFGSTLEMM 882
Query: 887 PEEDFEKHKEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMI 946
+FEKHK+A+C +L QK++N+ EE+ RY IYLGDYNF ++++KA+LV +TK++M+
Sbjct: 883 SNAEFEKHKDAICKTLQQKYRNLGEENDRYVTCIYLGDYNFLYKERKAQLVRQLTKKEML 942
Query: 947 DFYENYIMSENASKLILHLKSQVENKELNENELDTAKYPTGQLIEDVGAFKSTLFVAPVR 1006
DFY+ I S+ A+ L++H+++Q ++ +++D YPTG I DVGAFKS L++AP+R
Sbjct: 943 DFYQQTICSKQAASLVVHMQAQAGVQDSPADKVD--GYPTGNAITDVGAFKSQLYLAPIR 1000
Query: 1007 QPMKDFEISAP 1017
P+K FE++ P
Sbjct: 1001 APIKKFEVTTP 1011
>ref|XP_454175.1| unnamed protein product [Kluyveromyces lactis]
emb|CAG99262.1| unnamed protein product [Kluyveromyces lactis NRRL Y-1140]
Length = 1004
Score = 1187 bits (3070), Expect = 0.0, Method: Composition-based stats.
Identities = 584/980 (59%), Positives = 763/980 (77%), Gaps = 10/980 (1%)
Query: 40 TCL--SRYYTTNPYN--MTSNFKTFNLD--FLKPDLDERSYRFIELPNKLKALLIQDPKA 93
+CL SRY + YN M++ ++T D FLKPDLD+R YR+I+LPN LKALLI D +A
Sbjct: 23 SCLLTSRYRFLH-YNTKMSNKYRTLGTDSEFLKPDLDDRKYRYIQLPNNLKALLISDAEA 81
Query: 94 DKAAASLDVNIGAFEDPKNLPGLAHFCEHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTA 153
DKAAA+LDVNIG+F+DP++LPGLAHFCEHLLFMG+EK+PDEN+YSS+LSKHGGSSNAYT
Sbjct: 82 DKAAAALDVNIGSFQDPEHLPGLAHFCEHLLFMGNEKYPDENDYSSFLSKHGGSSNAYTG 141
Query: 154 SQNTNYFFEVNHQHLFGALDRFSGFFSCPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQ 213
SQNTNY+F +NH++L+ ALDRFSGFFSCPLFNK STDKEINAV+SENKKNLQNDIWR+YQ
Sbjct: 142 SQNTNYYFHLNHENLYPALDRFSGFFSCPLFNKASTDKEINAVDSENKKNLQNDIWRMYQ 201
Query: 214 LDKSLTNTKHPYHKFSTGNIETLGTLPKENGLNVRDELLKFHKNFYSANLMKLCILGRED 273
LDKSLTN +HPYHKFSTGNI+TLG +PK G+++R+ELL FHKN YSANLMKLC+LGRED
Sbjct: 202 LDKSLTNWEHPYHKFSTGNIKTLGDIPKLKGIDIRNELLDFHKNNYSANLMKLCVLGRED 261
Query: 274 LDTLSDWTYDLFKDVANNGREVPLYAEPIMQPEHLQKIIQVRPVKDLKKLEISFTVPDME 333
LDTL+DW Y+LFKDV N ++VP Y + L+K++ +PVKDLKK+E +F PDM+
Sbjct: 262 LDTLADWVYELFKDVPNLNKQVPYYPARLYTESQLKKMVYCKPVKDLKKIEFTFPTPDMD 321
Query: 334 EHWESKPPRILSHLIGHEGSGSLLAHLKKLGWANELSAGGHTVSKGNAFFAVDIDLTDNG 393
+WESKP LSHLIGHEG+GSLLA LK+ GWA ELSAG HT+SK NA F ++IDLTD+G
Sbjct: 322 PYWESKPNHYLSHLIGHEGNGSLLAFLKEKGWAVELSAGSHTISKDNAVFGIEIDLTDDG 381
Query: 394 LTHYRDVIVLIFQYIEMLKNSLPQKWIFNELQDISNATFKFKQAGSPSSTVSSLAKCLEK 453
+ H ++I+ FQY+EMLK +LP++WI NEL+ S ++FKFKQ PSSTVS++A+CLEK
Sbjct: 382 MNHVNEIIISTFQYLEMLKVTLPEEWIHNELKSTSVSSFKFKQKDPPSSTVSNMARCLEK 441
Query: 454 DYIPVSRILAMGLLTKYEPDLLTQYTDALVPENSRVTLISRSLETDSAEKWYGTAYKVVD 513
+YIPV IL+ L+ +Y P ++ +Y +L ENSR+ L ++L D E+WYGT YKV D
Sbjct: 442 EYIPVVDILSTSLIREYNPSMIKKYVQSLNWENSRIMLTGQNLPVDCKEQWYGTEYKVTD 501
Query: 514 YPADLIKNMKSPGLNPALTLPRPNEFVSTNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKK 573
YP L+K + + GLNP LPRPNEF+ T F+V+K+D +KPLDEP LL D SKLWYKK
Sbjct: 502 YPESLLKKLPNVGLNPKFHLPRPNEFICTKFEVNKLDNVKPLDEPFLLKDDHYSKLWYKK 561
Query: 574 DDRFWQPRGYIYLSFKLPHTHASIINSMLSTLYTQLANDALKDVQYDAACADLRISFNKT 633
DDRFW P+G+IY+S KLPHT +S++NSML++LY + DAL D+QYDA+CADLRI+ KT
Sbjct: 562 DDRFWVPKGHIYVSMKLPHTFSSVVNSMLTSLYVDMIKDALVDLQYDASCADLRITLGKT 621
Query: 634 NQGLAITASGFNEKLIILLTRFLQGVNSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMS 693
NQG+ I ASG+NEKL ILLTRFL+G+ SF+PK+ RF ++K++ ++ L N Y+VPY+Q+S
Sbjct: 622 NQGIDIQASGYNEKLTILLTRFLEGIKSFQPKESRFNVIKNRLLQKLSNQQYDVPYNQIS 681
Query: 694 NYYNAIINERSWSTAEKLQVFEKLTFEQLINFIPTIYEGVYFETLIHGNIKHEEALEVDS 753
N +N+++NERSW+T KL V + LTFE L +F+PTIYE ++ E+L+ GN E A E++
Sbjct: 682 NVFNSLVNERSWTTKAKLDVTKDLTFEHLKSFVPTIYEQLFHESLVLGNFSVEMAYEINQ 741
Query: 754 LIKSLIPNNIHNLQVSNNRLRSYLLPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSEDL 813
L+ L+ + I NL+V NN+LRSY+LP+ FRYE L+D NVNSCIQ++ QL YSE+L
Sbjct: 742 LVDILVVDRIPNLEVKNNKLRSYILPEESAFRYEYMLEDKANVNSCIQYLIQLGAYSEEL 801
Query: 814 SALSGLFAQLIHEPCFDTLRTKEQLGYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRIN 873
+A + L +QLIHEPCFDTLRTKEQLGY+VFS+ N HGT N+R+L+QSE + Y+E RI
Sbjct: 802 AAKASLVSQLIHEPCFDTLRTKEQLGYIVFSAVANTHGTTNLRVLVQSERDSAYVESRIV 861
Query: 874 NFYETFGQVLRDMPEEDFEKHKEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKK 933
F +FG+ L++MPEE FEKHK L +LLQK N+ +E R+T AIYL DYNF Q++
Sbjct: 862 KFLNSFGEALKEMPEEAFEKHKSGLIKNLLQKLTNLRQEYDRFTTAIYLADYNFCSYQRR 921
Query: 934 AKLVANITKQQMIDFYENYIMSENASKLILHLKSQVENKELNENELDTAKYPTGQLIEDV 993
A ++ ++K+ M++FY+N+++S +S+L +HLKSQ+E K E +PTG LI D+
Sbjct: 922 ADIITKLSKEDMVEFYKNFVLSPRSSRLAIHLKSQIEKKSTEEV---VEGFPTGTLISDI 978
Query: 994 GAFKSTLFVAPVRQPMKDFE 1013
FKS LF+APVRQ +K +E
Sbjct: 979 DEFKSNLFLAPVRQAVKQYE 998
>ref|XP_505854.1| hypothetical protein [Yarrowia lipolytica]
emb|CAG78665.1| unnamed protein product [Yarrowia lipolytica CLIB122]
Length = 1007
Score = 803 bits (2074), Expect = 0.0, Method: Composition-based stats.
Identities = 419/976 (42%), Positives = 609/976 (62%), Gaps = 16/976 (1%)
Query: 50 PYNMTSNFKTFNLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFED 109
P NMT F+ KP D+R YR I L N L+ALLI DP AD+A+A++DVN+G+F D
Sbjct: 39 PCNMTVPFQVIESSVDKPVTDDRQYRVITLANGLEALLIHDPDADRASAAMDVNVGSFSD 98
Query: 110 PKNLPGLAHFCEHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLF 169
P LPGLAHFCEHLLFMG+EK+P+EN+YS+YLS+H GSSNAYTAS+ TNYFF+V H++L
Sbjct: 99 PVGLPGLAHFCEHLLFMGTEKYPEENDYSTYLSEHSGSSNAYTASEETNYFFDVGHEYLE 158
Query: 170 GALDRFSGFFSCPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFS 229
GA DRF+ FF PLF + D+EI AV+SENKKNLQND+WR++QL++SL+N HPY++FS
Sbjct: 159 GAFDRFAQFFVAPLFAASAKDREIQAVDSENKKNLQNDMWRLFQLERSLSNPDHPYNRFS 218
Query: 230 TGNIETLGTLPKENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVA 289
TGN ETL T P E G++VR+ELLKF+K YS+N+MKL ILGRE LDTL W + V
Sbjct: 219 TGNYETLHTEPLEKGMDVREELLKFYKASYSSNIMKLVILGRESLDTLQSWVVEKLSSVV 278
Query: 290 NNGREVPLYAEPIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIG 349
N +P Y P++ L +++ +P+ D K +E++F VPD EHWES P SHL+G
Sbjct: 279 NTNATLPDYGVPLLTEGELGTLVKAKPIMDTKSIEVTFPVPDTREHWESHPGHYYSHLVG 338
Query: 350 HEGSGSLLAHLKKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIE 409
HEG GS+L LK GW + S+G V +G F + +LTD G+ HY+DV+V IF+Y+
Sbjct: 339 HEGPGSILFFLKNKGWVSSCSSGAVQVCRGAGVFTISCELTDAGMNHYKDVVVHIFEYLR 398
Query: 410 MLKNSLPQKWIFNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILAMGLLTK 469
ML++ Q+WI++E++D++ A F+F+Q +PSST S LA L+K+++P +L+ L K
Sbjct: 399 MLRDEPVQEWIYDEMRDVALANFRFRQKENPSSTTSRLATVLQKNHLPRQYLLSSSLFRK 458
Query: 470 YEPDLLTQYTDALVPENSRVTLISRSLE-TDSAEKWYGTAYKVVDYPADLIKNMKSPGLN 528
Y P+++ + +N ++ L+ + LE + EKWYGT Y AD ++ +KS G N
Sbjct: 459 YSPEVIQAFGRHFTTDNFKIFLVGQELEGLNQTEKWYGTQYSNDKIDADWMRRVKSAGRN 518
Query: 529 PALTLPRPNEFVSTNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSF 588
P L LP PNEF+ T+F V +P P LL + D +LW+K+DD F P+ + +
Sbjct: 519 PDLHLPAPNEFIPTDFSVPDKRAKEPQTHPTLLRNTDYVRLWHKRDDTFLVPKATVRIRL 578
Query: 589 KLPHTHASIINSMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKL 648
K P HA NS+ +TL ++ D L + Y A A L+ + G+ I +G+N KL
Sbjct: 579 KNPIGHADPFNSVKTTLLIEVVTDLLLEFAYAAEIAGLKYGVLASRDGVEIDLNGYNHKL 638
Query: 649 IILLTRFLQGVNSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTA 708
LL R L + +F+ + RF I+K+ + KN Y VPY+Q++++ ++N+ +W+
Sbjct: 639 ETLLERILLKIKNFDVDQSRFNIVKETVSKTYKNFGYNVPYAQVAHHSQYLLNDHTWTVQ 698
Query: 709 EKLQVFEKLTFEQLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLI-PNNIHNLQ 767
EK + E+LT E +I+F+P + ETL+ GN+ E+A+ + I +++ P + Q
Sbjct: 699 EKREKIEQLTREDIISFVPEFLRHLQVETLVVGNLAKEDAVSISQTISNVLKPAPLSPSQ 758
Query: 768 VSNNRLRSYLLPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSE-DLSALSGLFAQLIHE 826
+ N RS+LLP F Y+ L+D NVNS I ++ Q+ +S AL + AQ+ E
Sbjct: 759 LVNP--RSFLLPDSSAFHYDVDLEDKANVNSVIDYMVQVGKFSNIRTRALLEVLAQIGQE 816
Query: 827 PCFDTLRTKEQLGYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFY-ETFGQVLRD 885
P F+ LRTKEQLGYVVFS + T R+LIQSE T YLE RI N+ E G ++R+
Sbjct: 817 PSFNQLRTKEQLGYVVFSGIKSTRTTLLYRVLIQSEKTCSYLESRIENYLIEILGPMIRN 876
Query: 886 MPEEDFEKHKEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQM 945
M E +F+KH A+ L+K KN++EE++RY + I G Y+F K A+ + + K +
Sbjct: 877 MSEAEFDKHVAAVVAKKLEKRKNISEEASRYWSQIISGYYDFKQNFKDAEEIKTLKKADL 936
Query: 946 IDFYENYI--MSENASKLILHLKSQVENKELNENELDTAKYPTGQLIEDVGAFKSTLFVA 1003
++FY+ Y+ S+ SKL+++LKSQV D + P I D AFK++L +
Sbjct: 937 VEFYDRYVDPASKLRSKLVINLKSQVTK--------DEGQIPNSVPIIDHAAFKNSLSMT 988
Query: 1004 PVRQPMKDFEISAPPK 1019
P++D + PK
Sbjct: 989 EAPVPVEDLKNYMDPK 1004
>ref|XP_719241.1| a-factor pheromone maturation protease [Candida albicans SC5314]
ref|XP_719124.1| a-factor pheromone maturation protease [Candida albicans SC5314]
gb|EAL00228.1| potential a-factor pheromone maturation protease [Candida albicans
SC5314]
gb|EAL00350.1| potential a-factor pheromone maturation protease [Candida albicans
SC5314]
Length = 1107
Score = 763 bits (1969), Expect = 0.0, Method: Composition-based stats.
Identities = 421/961 (43%), Positives = 618/961 (64%), Gaps = 25/961 (2%)
Query: 28 SLNFTVRRFKPFTCLSRYYT--TNPYNMTSNFKTFNLDFLKPDLDERSYRFIELPNK-LK 84
SL T R F +S+YY+ +N + + S+ KT KP LD+RSYRFI+L N L+
Sbjct: 35 SLKLTTTR-SSFVSVSKYYSRMSNQFTILSDDKTIE----KPLLDDRSYRFIKLNNNGLR 89
Query: 85 ALLIQDPKADKAAASLDVNIGAFEDPK-NLPGLAHFCEHLLFMGSEKFPDENEYSSYLSK 143
LLI DP DKAAASLDVN+G+F D + N+ GLAHFCEHLLFMG+EK+P ENEYS+YLSK
Sbjct: 90 VLLINDPTTDKAAASLDVNVGSFTDKEYNISGLAHFCEHLLFMGTEKYPKENEYSNYLSK 149
Query: 144 HGGSSNAYTASQNTNYFFEVNHQHLFGALDRFSGFFSCPLFNKDSTDKEINAVNSENKKN 203
H GSSNAYTA+++TNY+F+V +L GALDRFS FF PLF+K D+EINAV+SENKKN
Sbjct: 150 HSGSSNAYTAAEHTNYYFQVGADYLEGALDRFSQFFIAPLFSKSCQDREINAVDSENKKN 209
Query: 204 LQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGTLPKENGLNVRDELLKFHKNFYSANL 263
LQ+D+WR+YQLDK +N+ HPY FSTGN +TL T P G++VRD L+ FHK YS+NL
Sbjct: 210 LQSDMWRLYQLDKFTSNSAHPYSGFSTGNYQTLHTDPVAKGVDVRDILIDFHKQHYSSNL 269
Query: 264 MKLCILGREDLDTLSDWTYDLFKDVANNGREVPLY-AEPIMQPEHLQKIIQVRPVKDLKK 322
M L ILG+EDL+TL++W + F V N P Y E + +P+ L K+I+ +P+ D K
Sbjct: 270 MSLVILGKEDLNTLTNWAIEKFSAVPNKDLSRPNYNGELVYKPQQLGKLIKAKPIMDNHK 329
Query: 323 LEISFTVP-DMEEHWESKPPRILSHLIGHEGSGSLLAHLKKLGWANELSAGGHTVSKGNA 381
+E++F +P D+E+ W++KP SHL+GHE GS++ +LK+ GWA +LSAG TV +G +
Sbjct: 330 MELNFLIPDDLEDKWDTKPNGYFSHLVGHESKGSIIYYLKQKGWATDLSAGAMTVCQGTS 389
Query: 382 FFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLPQKWIFNELQDISNATFKFKQAGSPS 441
F ++ LT G +++++IV+ FQY+ + N PQKWI++E++++S FKFKQ S
Sbjct: 390 NFYIEFQLTPKGFENWQEIIVITFQYLNFITNDEPQKWIWDEIEEMSQVNFKFKQKMEAS 449
Query: 442 STVSSLAKCLEK--DYIPVSRILAMGLLTKYEPDLLTQYTDALVPENSRVTLISRSLE-T 498
TVS+L+ L K +YIP S +L+ ++ K++P+ + ++ PEN R+TL S+ L
Sbjct: 450 KTVSTLSNKLYKFDEYIPASYLLSSAIVRKFDPEAIKRFGSYFTPENLRITLASQLLTGL 509
Query: 499 DSAEKWYGTAYKVVDYPADLIKNMKSPGL--NPALTLPRPNEFVSTNFKVDKIDGIKPLD 556
+ EKWYGT Y+ D P +LI +KS N L PRPN F+ TNF V K P
Sbjct: 510 NKQEKWYGTEYEYDDIPQELIHQIKSQPYDNNQNLHYPRPNHFIPTNFDVTKPKSKHPQV 569
Query: 557 EPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLPHTHASIINSMLSTLYTQLANDALKD 616
P L+ ++ +WYK+DD F P+G I ++F LP ++ I S++S L ++ +D L +
Sbjct: 570 APYLIEHNNKINVWYKQDDTFEVPKGSIEVAFHLPSSNTDINTSVMSNLAIEMLDDELNE 629
Query: 617 VQYDAACADLRISFNKTNQGLAITASGFNEKLIILLTRFLQGVNSFEPKKDRFEILKDKT 676
+ Y A L++ + G I SG++ KL LL L F+PK+DRFE +K K
Sbjct: 630 LTYFAELVGLKVKLHAWRDGFLINVSGYSHKLSNLLQEVLNNFFQFKPKQDRFESIKFKL 689
Query: 677 IRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKLQVFEKLTFEQLI-NFIPTIYE-GVY 734
+++ KN ++VP+ Q+ Y+ ++N++ + +K++ EK+T+E + +F I++ G++
Sbjct: 690 LKNFKNFGFQVPFQQVGVYHLQLLNDKLYQQDDKIEALEKVTYEDVYQHFTQNIWQSGIF 749
Query: 735 FETLIHGNIKHEEALEVDSLIKSLIPNNIHNLQVSNNR---LRSYLLPKGKTFRYETALK 791
E LIHGN ++ ++ +I + N ++ N L+SY+L +T RYE LK
Sbjct: 750 AEVLIHGNFDFAQSKQIRDIINESMENVKPWMEKYNEEQFHLQSYVLQPNETIRYEVPLK 809
Query: 792 DSQNVNSCIQHVTQLDVYSEDLS--ALSGLFAQLIHEPCFDTLRTKEQLGYVVFSSSLNN 849
D+ N+NSCI++ Q++ +++L L+ LFA +I EPCFD LRTKEQLGYVVFS ++
Sbjct: 810 DTANINSCIEYYIQINTNTDNLKLRVLTDLFATIIREPCFDQLRTKEQLGYVVFSGTVLG 869
Query: 850 HGTANIRILIQSEHTTPYLEWRINNFYETFGQVL-RDMPEEDFEKHKEALCNSLLQKFKN 908
T R+LIQSE T YL++RI F FG + ++ EDF K K AL N L K K+
Sbjct: 870 RTTLGFRVLIQSERTCDYLQYRIEEFLVQFGNYINNELSTEDFIKFKHALKNIKLTKLKH 929
Query: 909 MAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMIDFYENYIM-SENASKLILHLKS 967
+ EE+ R + I G Y+F R ++ +++ NITK ++++F+ +I S+N KLI +LKS
Sbjct: 930 LNEETVRIWSNIIDGYYDFDSRTRQVEILENITKDELVEFFNTFIAKSDNTGKLITYLKS 989
Query: 968 Q 968
Q
Sbjct: 990 Q 990
>ref|XP_001524140.1| conserved hypothetical protein [Lodderomyces elongisporus NRRL
YB-4239]
gb|EDK46772.1| conserved hypothetical protein [Lodderomyces elongisporus NRRL
YB-4239]
Length = 1132
Score = 748 bits (1930), Expect = 0.0, Method: Composition-based stats.
Identities = 420/964 (43%), Positives = 606/964 (62%), Gaps = 22/964 (2%)
Query: 41 CLSRYYT-TNPYNMTSNFKTFNLD--FLKPDLDERSYRFIEL-PNKLKALLIQDPKADKA 96
C+SR + TN ++ S + D KP +D+RSYRFI+L N LK LLI DP+ADK+
Sbjct: 62 CISRSTSKTNMPDLNSQYTIVVDDSQIEKPVIDDRSYRFIKLNSNDLKVLLIHDPQADKS 121
Query: 97 AASLDVNIGAFEDPK-NLPGLAHFCEHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQ 155
AA+LDVN+G+F D + +PGLAHFCEHLLFMG+EK+P ENEYS+YLSKH G SNAYT+S+
Sbjct: 122 AAALDVNVGSFADKQYGIPGLAHFCEHLLFMGTEKYPKENEYSNYLSKHSGHSNAYTSSE 181
Query: 156 NTNYFFEVNHQHLFGALDRFSGFFSCPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLD 215
+TNY+F+V HL GALDRF+ FF PLF+K D+EINAV+SENKKNLQND WR+YQLD
Sbjct: 182 HTNYYFQVGSNHLEGALDRFAQFFISPLFSKTCKDREINAVDSENKKNLQNDDWRLYQLD 241
Query: 216 KSLTNTKHPYHKFSTGNIETLGTLPKENGLNVRDELLKFHKNFYSANLMKLCILGREDLD 275
K +N HPY+ FSTGN +TL P+ G+NVRD L++FHK++YS+NLM L I+G+EDLD
Sbjct: 242 KMFSNPDHPYNGFSTGNYQTLHVEPELRGVNVRDVLMQFHKDYYSSNLMSLVIMGKEDLD 301
Query: 276 TLSDWTYDLFKDVANNGREVPLYAEPIM--QPEHLQKIIQVRPVKDLKKLEISFTVP-DM 332
TLS W F + N VP Y ++ Q HL K+I+ +PVK++ +LE+SF VP D+
Sbjct: 302 TLSKWAIKKFLPILNQSLSVPSYEGQLIYKQSHHLGKVIKAKPVKEMHQLELSFMVPDDL 361
Query: 333 EEHWESKPPRILSHLIGHEGSGSLLAHLKKLGWANELSAGGHTVSKGNAFFAVDIDLTDN 392
E W SKP SHL+GHE GS+L +LK GW ELS+G VS GN+ + V+ LT
Sbjct: 362 ENKWASKPQSYFSHLLGHESEGSILYYLKHKGWVTELSSGNMKVSLGNSVYMVEFQLTPT 421
Query: 393 GLTHYRDVIVLIFQYIEMLKNSLPQKWIFNELQDISNATFKFKQAGSPSSTVSSLAKCLE 452
GL ++ ++ F+Y+ ++ P+KWI+ E+++IS FKFKQ SSTVSS++ L
Sbjct: 422 GLKNWETIVATTFEYLALILKDDPKKWIWEEIRNISEINFKFKQKADASSTVSSMSNSLY 481
Query: 453 K--DYIPVSRILAMGLLTKYEPDLLTQYTDALVPENSRVTLISRSLET-DSAEKWYGTAY 509
K YIP IL ++ ++P + ++ L P+N R+TL+S+S + E WYGT Y
Sbjct: 482 KFDKYIPAENILCSSVVRDFDPLAIKKFGSYLNPDNFRITLVSQSFDNLTQKEPWYGTEY 541
Query: 510 KVVDYPADLIKNMKSPGLNPALTLPRPNEFVSTNFKVDKIDGIKPLDEPVLLLSDDVSKL 569
++ D P +L K + +P N L P PN F+ TNF + KI P P L+ D+ +
Sbjct: 542 EIEDVPKNLKKIIDNPLPNKHLHYPEPNPFIPTNFNISKIKVQTPQTAPYLIHHDNKMNV 601
Query: 570 WYKKDDRFWQPRGYIYLSFKLPHTHASIINSMLSTLYTQLANDALKDVQYDAACADLRIS 629
WYK+DD+F P+G I L F LP ++ +++S S ++T++ +D L + Y A+ LR+
Sbjct: 602 WYKQDDQFEVPKGTIELVFHLPSSNVDVVSSTKSGVFTEMLSDQLNQITYFASLVGLRVG 661
Query: 630 FNKTNQGLAITASGFNEKLIILLTRFLQGVNSFEPKKDRFEILKDKTIRHLKNLLYEVPY 689
N G AI SG+N+KL ILL + L F P K+RFE +K K ++ +N + VPY
Sbjct: 662 INTWRDGFAIFISGYNDKLPILLDQVLNKFIEFSPDKNRFEPIKFKLLKEYRNFGFMVPY 721
Query: 690 SQMSNYYNAIINERSWSTAEKLQVFEKLTFEQLINFI-PTIYE-GVYFETLIHGNIKHEE 747
+Q+ +++ ++NE+ + E+++ E+L F+ + +FI TI+ G++ E LIHGN
Sbjct: 722 NQIGSHHLQLVNEKVYDFEERIKALEQLQFQDVESFINKTIWSLGIFAEVLIHGNFDITT 781
Query: 748 ALEVDSLIK---SLIPNNIHNLQVSNNRLRSYLLPKGKTFRYETALKDSQNVNSCIQHVT 804
A ++ + + S IP + S L++++L +G+ R+E L D N+NSCI++
Sbjct: 782 ARKIKTSVSDHISRIPPLMEEYDPSKIYLQNFILQEGEAIRFEKELLDKNNINSCIEYYL 841
Query: 805 QLDVYSED--LSALSGLFAQLIHEPCFDTLRTKEQLGYVVFSSSLNNHGTANIRILIQSE 862
Q ++D L L+ L A +I EPCFD LRTKEQLGYVVFS + RIL+QSE
Sbjct: 842 QFSPNNDDPKLRVLTDLLATIIREPCFDQLRTKEQLGYVVFSGVKKGRTSLGFRILVQSE 901
Query: 863 HTTPYLEWRINNFYETFGQVLR-DMPEEDFEKHKEALCNSLLQKFKNMAEESARYTAAIY 921
++ YLE+RI F FG + ++ ++DF K K+AL + LQK K++ EE+ R +I
Sbjct: 902 RSSEYLEYRIEEFLAKFGSFVNLELSDKDFAKFKQALKDMKLQKLKHLNEETNRIWNSIT 961
Query: 922 LGDYNFTHRQKKAKLVANITKQQMIDFYENYIMSENAS---KLILHLKSQVENKELNENE 978
G Y+F RQK ++ NITK F+ Y+ ++ S KL++HLKS NK +
Sbjct: 962 DGYYDFDARQKHVDILENITKDDFTQFFNAYVGDKDYSRTGKLVVHLKSAKVNKPADAKL 1021
Query: 979 LDTA 982
+ +A
Sbjct: 1022 VQSA 1025
>ref|XP_001397499.1| hypothetical protein An16g01860 [Aspergillus niger]
emb|CAK42803.1| unnamed protein product [Aspergillus niger]
Length = 1167
Score = 735 bits (1898), Expect = 0.0, Method: Composition-based stats.
Identities = 392/926 (42%), Positives = 577/926 (62%), Gaps = 28/926 (3%)
Query: 66 KPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNLPGLAHFCEHLLF 125
KP+LD+RSYR I LPNKL+ALL+ DP DKA+A+++VN+G F D ++PG+AH EHLLF
Sbjct: 97 KPELDDRSYRVIRLPNKLEALLVHDPDTDKASAAVNVNVGNFSDADDMPGMAHAVEHLLF 156
Query: 126 MGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNH--------QHLFGALDRFSG 177
MG++K+P EN Y+ YL+ H GSSNAYTA+ TNYFFE++ L+GALDRF+
Sbjct: 157 MGTQKYPKENAYNQYLASHSGSSNAYTAATETNYFFEIDTPAKPNYPTSPLYGALDRFAQ 216
Query: 178 FFSCPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLG 237
FF PLF + + D+E+ AV+SENKKNLQ+D+WR+ QL+K+L+N HPYH FSTGN++TL
Sbjct: 217 FFVEPLFLESTLDRELRAVDSENKKNLQSDLWRLMQLNKTLSNPAHPYHHFSTGNLQTLK 276
Query: 238 TLPKENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGREVPL 297
P++ GL VR E +KF++ YS+N+MKL +LGR+ LD + W DLFK V N +++P
Sbjct: 277 EEPQKRGLEVRQEFIKFYQAHYSSNIMKLVVLGRDPLDEMEQWVGDLFKHVKN--QDLPQ 334
Query: 298 ----YAEPIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGS 353
+A+P + PEHL K I +PV D++ L+I F D E +ES+P R LSHLIGHEG
Sbjct: 335 NRWDHAQPCL-PEHLGKQIFAKPVMDMRSLDIYFPFMDEESMFESQPSRYLSHLIGHEGP 393
Query: 354 GSLLAHLKKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKN 413
GS+LA++K GWAN LSAG V G+AFF + + LT GL YR+V ++F+YI M+K
Sbjct: 394 GSILAYIKAKGWANGLSAGVMPVCPGSAFFTISVRLTPEGLKQYREVTKVVFEYIGMIKE 453
Query: 414 SLPQKWIFNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILAMGLLTKYEPD 473
PQ+WIF+E+++++ F+FKQ S S L+ ++K Y P +L+ LL K+EP+
Sbjct: 454 REPQQWIFDEMKNLAEVEFRFKQKSPASRFTSRLSSVMQKPY-PREWLLSGSLLRKFEPE 512
Query: 474 LLTQYTDALVPENSRVTLISRSLETD--SAEKWYGTAYKVVDYPADLIKNM-KSPGLNPA 530
L+ + L P+N R+ ++++ D EKWYGT YKV D P D + ++ K+ +P
Sbjct: 513 LVKKALSYLRPDNFRMVIVAQDYPGDWNCREKWYGTEYKVEDIPQDFMDSIRKAVETSPE 572
Query: 531 -----LTLPRPNEFVSTNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIY 585
L +P NEFV T V+K + +P P L+ DD +LWYKKDDRFW P+ ++
Sbjct: 573 SRLSELHMPHKNEFVPTRLSVEKKEVSEPAKTPKLIRHDDHVRLWYKKDDRFWVPKATVH 632
Query: 586 LSFKLPHTHASIINSMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFN 645
++ + P A+ N + + Y++L DAL + YDA A L S + + GL I+ G+N
Sbjct: 633 ITLRNPLVWATPANLVKAKFYSELVRDALNEYSYDAELAGLDYSLSASLFGLDISVGGYN 692
Query: 646 EKLIILLTRFLQGVNSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSW 705
+K+ +LL + L + K DRF I+K++ R+ KN Y+ P+ Q+ +Y + ER+W
Sbjct: 693 DKMSVLLEKVLTSMRDLVVKPDRFNIIKERMTRNYKNAEYQQPFYQVGDYTRYLTAERTW 752
Query: 706 STAEKLQVFEKLTFEQLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIHN 765
+ E + E + F P I + E L HGN+ E+AL + L++S + +
Sbjct: 753 LNEQYAAELEHIEAEDVSCFFPQILRQNHIEVLAHGNLYKEDALRMTDLVESTLQSRTLP 812
Query: 766 LQVSNNRLRSYLLPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSED-LSALSGLFAQLI 824
R R+ +LP G + YE LKD NVN CI++ + +D L A LFAQ+
Sbjct: 813 ESQWYVR-RNMILPPGANYIYERTLKDPANVNHCIEYYLFIGKIDDDALRAKLLLFAQMT 871
Query: 825 HEPCFDTLRTKEQLGYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVLR 884
EP FD LR+KEQLGYVV+S + + T R++IQSE PYLE RI++F FG+ L+
Sbjct: 872 DEPAFDQLRSKEQLGYVVWSGARYSATTMGYRVIIQSERNAPYLESRIDSFLTGFGKSLQ 931
Query: 885 DMPEEDFEKHKEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQ 944
+M E+DFE HK ++ N L+K KN++ E+ R+ + I ++F + A V +T+
Sbjct: 932 NMSEQDFENHKRSVVNKRLEKLKNLSSETNRFWSHIGSEYFDFVQNESDAANVRKLTQAD 991
Query: 945 MIDFYENYI--MSENASKLILHLKSQ 968
+I F++ ++ S +KL +HLK+Q
Sbjct: 992 LIQFFQQFVDPTSATRAKLAIHLKAQ 1017
>ref|XP_001486793.1| hypothetical protein PGUG_00170 [Pichia guilliermondii ATCC 6260]
gb|EDK36072.1| hypothetical protein PGUG_00170 [Pichia guilliermondii ATCC 6260]
Length = 922
Score = 731 bits (1887), Expect = 0.0, Method: Composition-based stats.
Identities = 398/880 (45%), Positives = 553/880 (62%), Gaps = 19/880 (2%)
Query: 66 KPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPK-NLPGLAHFCEHLL 124
KP LD+RSYR I+L N L AL+I DP DK+AASLDVN+GAF D K + GLAHFCEHLL
Sbjct: 40 KPLLDDRSYRLIKLQNDLHALVIHDPTTDKSAASLDVNVGAFADRKYEVSGLAHFCEHLL 99
Query: 125 FMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGALDRFSGFFSCPLF 184
FMG++K+P+ENEYSSYL+KH G SNAYTA+++TNY+FEV H GALDRF+ FF PLF
Sbjct: 100 FMGTKKYPEENEYSSYLAKHSGHSNAYTAAEHTNYYFEVGSGHFLGALDRFAQFFIAPLF 159
Query: 185 NKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGTLPKENG 244
+K D+EI AV+SENKKNLQND+WR+YQL+K +N HPY FSTGN TL P G
Sbjct: 160 SKSCKDREIRAVDSENKKNLQNDMWRLYQLEKLTSNPSHPYSGFSTGNFHTLHEEPIAQG 219
Query: 245 LNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGREVPLY-AEPIM 303
NVRD L+ FH N YS+NLM L +LG+EDLDTLS W DL+ D+ N P Y I
Sbjct: 220 KNVRDVLIDFHLNQYSSNLMSLVVLGKEDLDTLSTWVSDLYSDIPNKSLSRPDYEGSVIF 279
Query: 304 QPEHLQKIIQVRPVKDLKKLEISFTVP-DMEEHWESKPPRILSHLIGHEGSGSLLAHLKK 362
PE L K++Q +P+ D KLE++F +P D EE+WESKP SHL+GHE SGSLL +LK+
Sbjct: 280 APEQLGKLVQAKPIMDSNKLELNFMIPDDQEEYWESKPSGYFSHLLGHESSGSLLHYLKE 339
Query: 363 LGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLPQKWIFN 422
W NELSAG V +G++ F ++ +LT GL H++D++V +F+YI M+ PQKW++
Sbjct: 340 KSWVNELSAGNMKVCQGSSLFIIEFELTPAGLDHWQDIVVNVFEYISMVTTQEPQKWLWE 399
Query: 423 ELQDISNATFKFKQAGSPSSTVSSLAKCLEK----DYIPVSRILAMGLLTKYEPDLLTQY 478
E++ +S FKF+Q +STVS ++ L K +IP + +L+ + K++P+ +T++
Sbjct: 400 EIKLMSEIDFKFRQKKGAASTVSKMSSSLYKFWDNSFIPPTHLLSSSINRKFDPEAITKF 459
Query: 479 TDALVPENSRVTLISRSLE-TDSAEKWYGTAYKVVDYPADLIKNMKSPGLNPALTLPRPN 537
L PEN+R+TLIS+ LE D EKWYGT Y + + L++ K N PRPN
Sbjct: 460 GSYLFPENARITLISKKLEGLDMKEKWYGTDYSLSTIDSSLLERAKLAAKNDRFHFPRPN 519
Query: 538 EFVSTNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLPHTHASI 597
F+ NF V KPL P L+ ++W+K+DD+F P+G I + LP T+
Sbjct: 520 PFIPKNFDVANKKLEKPLKHPFLISDTSKFQVWFKQDDQFLVPKGTIEILLHLPDTNTDC 579
Query: 598 INSMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLIILLTRFLQ 657
+S+ S L +L D L D+ Y A+ + + GL + SG+N+KL +LL L
Sbjct: 580 KSSVFSMLMAELVADELTDIVYYASLVGMSFKLSHWRDGLLVKVSGYNDKLPVLLETVLS 639
Query: 658 GVNSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKLQVFE-K 716
+ SF PKKDRFE LK K I+ L N Y VPY Q+ + + I+N+++++ ++++V +
Sbjct: 640 KIKSFVPKKDRFETLKYKMIQDLTNFGYNVPYIQIGTHMSVIMNDKTYTHEDRVKVLQNN 699
Query: 717 LTFEQLINFIPTIYE-GVYFETLIHGNIKHEEALEVDSLIKSLIPNNIHNLQVSNN---- 771
+ FE F ++E G++ E I GN +E+A + S I S N+ + S N
Sbjct: 700 VDFEGFGLFCSKVWELGLFGEAHIQGNFSYEKACGISSSIDSEF-RNVRAIGASKNDIDN 758
Query: 772 --RLRSYLLPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSEDL--SALSGLFAQLIHEP 827
RL+S++L G+T R E L D +NVNSCI++ Q++ D+ L+ L ++HEP
Sbjct: 759 VVRLQSHILQPGETVRVEMDLMDEKNVNSCIEYYIQIENSLSDIRKRTLTDLLETIMHEP 818
Query: 828 CFDTLRTKEQLGYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVLRDMP 887
CF+ LRTKEQLGYVVFS + RILIQSE T YLE+RI F + F + ++
Sbjct: 819 CFNQLRTKEQLGYVVFSGVRLSRTAIGFRILIQSERLTSYLEYRIEEFLKRFSVYVNELT 878
Query: 888 EEDFEKHKEALCNSLLQKFKNMAEESARYTAAIYLGDYNF 927
E F+ K+AL + L K KN++EE +R+ AI G Y+F
Sbjct: 879 AEQFDGFKQALKDKKLTKLKNLSEEVSRFWEAIADGYYDF 918
>gb|EDU43925.1| insulin-degrading enzyme [Pyrenophora tritici-repentis Pt-1C-BFP]
Length = 1098
Score = 728 bits (1878), Expect = 0.0, Method: Composition-based stats.
Identities = 402/969 (41%), Positives = 567/969 (58%), Gaps = 48/969 (4%)
Query: 63 DFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNLPGLAHFCEH 122
D +P LD+RSYR I LPN+L+ LLI + DKA+A+LDVN+G+F D ++PG+AH EH
Sbjct: 17 DLERPQLDDRSYRIITLPNQLEVLLIHEAGTDKASAALDVNVGSFSDAPDMPGIAHAVEH 76
Query: 123 LLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQH--------------- 167
LLFMG+EK+P+EN Y+ YL++HGG SNA+TAS +TNY+FE+++
Sbjct: 77 LLFMGTEKYPEENAYNQYLTRHGGYSNAFTASTSTNYYFELSYPSSSPKSSKTPTPDASQ 136
Query: 168 -----------LFGALDRFSGFFSCPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDK 216
L+G LDRF FF PLF +D+ D+E+ AV+SENKKNLQND WR++QLDK
Sbjct: 137 VNLSEPKEVSPLWGGLDRFGQFFISPLFLEDTVDRELKAVDSENKKNLQNDTWRMHQLDK 196
Query: 217 SLTNTKHPYHKFSTGNIETLGTLPKENGLNVRDELLKFHKNFYSANLMKLCILGREDLDT 276
+L N HPY+ FSTG+ +TL P G+ +RDE +KFH YSAN MKL +LGRE LDT
Sbjct: 197 ALANPDHPYNHFSTGSYKTLHDEPIARGVKIRDEFIKFHSTHYSANRMKLVVLGRESLDT 256
Query: 277 LSDWTYDLF-----KDVANNGREVPLYAEPIMQPEHLQKIIQVRPVKDLKKLEISFTVPD 331
L W ++F KD+ N ++P+Y E + + RPV + L+I F D
Sbjct: 257 LETWVEEIFSKVPNKDLGKNRWDMPVYTEKELLTQTF-----ARPVLQSRSLQIQFAYRD 311
Query: 332 MEEHWESKPPRILSHLIGHEGSGSLLAHLKKLGWANELSAGGHTVSKGNAFFAVDIDLTD 391
E+++ES P R LSHL+GHEG GS+LAH+K GWAN L AGG T+ G+ F ++I LT+
Sbjct: 312 EEKYYESHPSRYLSHLLGHEGPGSILAHIKAKGWANGLGAGGSTLCPGSGLFTINIKLTE 371
Query: 392 NGLTHYRDVIVLIFQYIEMLKNSLPQKWIFNELQDISNATFKFKQAGSPSSTVSSLAKCL 451
GL +Y++V L+FQYI ++ + PQ+W+ E IS F+FKQ PS T S LA +
Sbjct: 372 EGLKNYKEVTKLVFQYIGLMCDKPPQEWVVEEQMRISEVEFRFKQKSPPSRTASGLAGIM 431
Query: 452 EKDYIPVSRILAMGLLTKYEPDLLTQYTDALVPENSRVTLISRSLET--DSAEKWYGTAY 509
++ Y + + K++ +L+ + L P+N R+T+IS+ D EKWYGT +
Sbjct: 432 QRPYERKMLLSGPATIKKFDSELIREALSYLRPDNFRMTIISQDFPGGWDQKEKWYGTEH 491
Query: 510 KVVDYPADLIKNMK----SPGLNPALTLPRPNEFVSTNFKVDKIDGIKPLDEPVLLLSDD 565
KV P + + +K S L P NEF+ T V+K + +P EP L+ DD
Sbjct: 492 KVERIPDEFLTEIKQAFESKSRPAELHFPHKNEFIPTRLNVEKKEVEQPTKEPKLIRHDD 551
Query: 566 VSKLWYKKDDRFWQPRGYIYLSFKLPHTHASIINSMLSTLYTQLANDALKDVQYDAACAD 625
++W+KKDD+FW P+ +++ F+ P T+ + ++L TLY +L NDAL + YDA +
Sbjct: 552 NVRVWWKKDDQFWVPKANVHIYFRTPITNVTARITLLCTLYRELVNDALVEYAYDADISG 611
Query: 626 LRISFNKTNQGLAITASGFNEKLIILLTRFLQGVNSFEPKKDRFEILKDKTIRHLKNLLY 685
L F GL+IT SG+N+KL +LL + L V + + RF I+ D+ +R L+N Y
Sbjct: 612 LVYDFTNHINGLSITVSGYNDKLHVLLEKVLLQVRDLKVSEGRFNIIHDRMLRSLRNWQY 671
Query: 686 EVPYSQMSNYYNAIINERSWSTAEKLQVFEKLTFEQLINFIPTIYEGVYFETLIHGNIKH 745
P+ Q+ Y E+S E L E +T + + F P I E L HGN+
Sbjct: 672 GQPFHQVGTYSRQFKTEKSVMNEELLPELENVTAQDVQQFFPQILAQCQIEVLAHGNLYK 731
Query: 746 EEALEVDSLI-KSLIPNNIHNLQVSNNRLRSYLLPKGKTFRYETALKDSQNVNSCIQH-V 803
EEAL++ L+ +++ P + QV R L P G F YE LKD +NVN CI++ +
Sbjct: 732 EEALKITDLVERTMKPRRLPADQVPTR--RGLLWPSGCNFIYEKQLKDPENVNHCIEYSL 789
Query: 804 TQLDVYSEDLSALSGLFAQLIHEPCFDTLRTKEQLGYVVFSSSLNNHGTANIRILIQSEH 863
Y L A L Q+ EPCF+ LRT EQLGYVVFS S + + RILIQSE
Sbjct: 790 YAGHNYDSVLRAKLLLLGQMTDEPCFNQLRTIEQLGYVVFSGSSFHDVWSGYRILIQSEK 849
Query: 864 TTPYLEWRINNFYETFGQVLRDMPEEDFEKHKEALCNSLLQKFKNMAEESARYTAAIYLG 923
YLE RI NF TF + L +M EEDFE HK+A+ N L K KN++ E R+ IY
Sbjct: 850 DCRYLEGRIENFLTTFEKTLNEMSEEDFESHKQAMINKRLAKLKNLSSEDNRFWNHIYSD 909
Query: 924 DYNFTHRQKKAKLVANITKQQMIDFYENYI--MSENASKLILHLKSQVENKELNENELDT 981
Y+F A + +TK++M+DFY YI S + SKL +HL++Q + KE + E T
Sbjct: 910 SYDFLQADVDAANLEKLTKKEMVDFYGRYISTSSPHRSKLSVHLQAQSKAKEPSLEEKKT 969
Query: 982 AKYPTGQLI 990
A + ++I
Sbjct: 970 AAVASLKII 978
>ref|XP_456547.1| hypothetical protein DEHA0A05214g [Debaryomyces hansenii CBS767]
emb|CAG84502.1| unnamed protein product [Debaryomyces hansenii CBS767]
Length = 1102
Score = 724 bits (1868), Expect = 0.0, Method: Composition-based stats.
Identities = 414/929 (44%), Positives = 593/929 (63%), Gaps = 22/929 (2%)
Query: 61 NLDFLKPDLDERSYRFIEL-PNKLKALLIQDPKADKAAASLDVNIGAFEDPK-NLPGLAH 118
N + KP LD+RSYR I+L N L L+I D DKAAASLDVN+G+F D +PGLAH
Sbjct: 43 NSNVEKPILDDRSYRLIKLNSNDLHVLIINDASTDKAAASLDVNVGSFADKNYQVPGLAH 102
Query: 119 FCEHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGALDRFSGF 178
FCEHLLFMG+ K+P+ENEYSSYLSKH G SNAYTA+++TNY+FE++ +L GALDRFS F
Sbjct: 103 FCEHLLFMGTSKYPEENEYSSYLSKHSGHSNAYTAAEHTNYYFELSSDYLEGALDRFSQF 162
Query: 179 FSCPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGT 238
F PLF+K D+EI AV+SENKKNLQND+WR YQLDK +N +HPY+ FSTGN ETL
Sbjct: 163 FISPLFSKSCKDREIKAVDSENKKNLQNDMWRFYQLDKLTSNPQHPYNGFSTGNYETLHE 222
Query: 239 LPKENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGREVPLY 298
P GLNVRD LL F+KN YS+NLM L ILG+EDLDTL+ W D F +V N+ P Y
Sbjct: 223 EPTSQGLNVRDILLDFYKNHYSSNLMSLVILGKEDLDTLTSWAIDKFSEVPNSNLPRPNY 282
Query: 299 -AEPIMQPEHLQKIIQVRPVKDLKKLEISFTVP-DMEEHWESKPPRILSHLIGHEGSGSL 356
E I P+HL KII+ +P+ D KLE+SF VP D E +W+SKP SHL+GHE SGS+
Sbjct: 283 DGELIYNPDHLGKIIKAKPIMDSNKLELSFMVPSDQEANWDSKPASYYSHLLGHESSGSI 342
Query: 357 LAHLKKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLP 416
L +LK+ GW NELSAG V +GN+ F ++ DLT NGL ++ ++V +F+Y++++ N P
Sbjct: 343 LHYLKQKGWVNELSAGNMKVCQGNSIFVLEFDLTPNGLKNWEAIVVNVFEYLKLVLNGEP 402
Query: 417 QKWIFNELQDISNATFKFKQAGSPSSTVS----SLAKCLEKDYIPVSRILAMGLLTKYEP 472
+ W++ EL ++S FKFKQ + TVS SL K E YIP +L+ +L +++
Sbjct: 403 KLWLWEELSNMSTINFKFKQKQRAAQTVSKMSNSLYKFTEGSYIPPQYLLSSSILREFKS 462
Query: 473 DLLTQYTDALVPENSRVTLISRSL-ETDSAEKWYGTAYKVVDYPADLIKNMKSPGLNPAL 531
+ +Y L P+N R+ L S+SL + D +E WYGT Y +L ++S N
Sbjct: 463 QEIKEYGSFLNPDNFRILLTSQSLPDLDKSEHWYGTQYSYESISNNLKDQIESAETNENF 522
Query: 532 TLPRPNEFVSTNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLP 591
P PN+F+ +F V K PL P L+ ++ ++WYK+DD+F P+G I + L
Sbjct: 523 HYPIPNKFIPKDFTVSKPKLENPLPHPYLIEDNNKFQVWYKQDDQFQIPKGAIEIVLHLA 582
Query: 592 HTHASIINSMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLIIL 651
+ + S +S+ + L +QL +D L ++ Y A+ + + N GL I SG+N+KL +L
Sbjct: 583 NANTSCKSSIYTMLLSQLIDDELNEIVYYASMVGISFTINHWRDGLLIRVSGYNDKLPVL 642
Query: 652 LTRFLQGVNSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKL 711
L + LQ + +F+PK+DRFE+ K K + KN +EVPYSQ+ ++ ++N++++ K+
Sbjct: 643 LEQILQKLITFKPKEDRFEVFKFKLNQEFKNFGFEVPYSQIGTHFLTLLNDKTYPYDLKI 702
Query: 712 QVFEK-LTFEQLINF-IPTIYE-GVYFETLIHGNIKHEEALEVDSLIKSLIP--NNIHNL 766
K + F +L+ F I+E GV+ E LI GN +A E+ I+ I +
Sbjct: 703 DTLNKEINFGELLEFSTNKIWEQGVFGEVLIQGNFNDTKAFEISRAIQGHFTEFKTIRDS 762
Query: 767 QVSNN---RLRSYLLPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSED--LSALSGLFA 821
Q N +L+++++P + RYE AL+D N+NSCI++ Q+ +D L L+ L
Sbjct: 763 QEEINEIVKLKTHIVPSNQRIRYEVALQDKNNINSCIEYFIQISDSFDDVRLRVLTDLLG 822
Query: 822 QLIHEPCFDTLRTKEQLGYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQ 881
+IHEPCF+ LRTKEQLGYVVFS + T RILIQSE ++ YLE+RI F F +
Sbjct: 823 TVIHEPCFNQLRTKEQLGYVVFSGTRLTRTTLGFRILIQSERSSEYLEYRIEEFINQFDK 882
Query: 882 -VLRDMPEEDFEKHKEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANI 940
V + + +E+F K K+AL + L K KN++EE +++ +I G Y+F R+K +++ +I
Sbjct: 883 FVKKGLTDENFAKFKQALKDKKLTKLKNLSEEVSKFWNSIISGYYDFQEREKHVEVLESI 942
Query: 941 TKQQMIDFYENYIMSEN--ASKLILHLKS 967
TK + I FY +YI +++ +S++I+HLKS
Sbjct: 943 TKDEFIKFYNDYISADSNVSSRIIVHLKS 971
>ref|XP_001383768.2| hypothetical protein PICST_56651 [Pichia stipitis CBS 6054]
gb|ABN65739.2| predicted protein [Pichia stipitis CBS 6054]
Length = 1074
Score = 723 bits (1867), Expect = 0.0, Method: Composition-based stats.
Identities = 402/926 (43%), Positives = 600/926 (64%), Gaps = 24/926 (2%)
Query: 66 KPDLDERSYRFIEL-PNKLKALLIQDPKADKAAASLDVNIGAFEDPK-NLPGLAHFCEHL 123
KP LD R+YR+++L N L+ L+I D ADK+AASLDVN+G+F D K +PGLAHFCEHL
Sbjct: 25 KPLLDNRTYRYLKLDSNDLQVLVIHDSTADKSAASLDVNVGSFADKKYGIPGLAHFCEHL 84
Query: 124 LFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGALDRFSGFFSCPL 183
LFMG+EK+P ENEYSSYLSKH G SNAYTA+++TNY+F+V+ +L GALDRF+ FF PL
Sbjct: 85 LFMGTEKYPAENEYSSYLSKHSGYSNAYTAAEHTNYYFQVSADYLEGALDRFAQFFVAPL 144
Query: 184 FNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGTLPKEN 243
F++ D+EINAV+SENKKNLQND+WR+YQLDKS +N HPY+ FSTGN +TL P E
Sbjct: 145 FSQSCKDREINAVDSENKKNLQNDLWRLYQLDKSNSNPDHPYNGFSTGNYQTLHVEPSER 204
Query: 244 GLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGREVP-LYAEPI 302
GLNVRD LL F+ N YS+NLM L +LG+EDLDTLS W + F V N P + E I
Sbjct: 205 GLNVRDVLLDFYSNSYSSNLMSLVVLGKEDLDTLSAWAIEKFSAVPNKSLTRPNFHGEVI 264
Query: 303 MQPEHLQKIIQVRPVKDLKKLEISFTVP-DMEEHWESKPPRILSHLIGHEGSGSLLAHLK 361
+ ++L K+ + +P+ D +LE++F VP D+E W+SKP SHL+GHE GS+L LK
Sbjct: 265 LTDKYLGKLTRAKPIMDKHQLELTFMVPDDLETKWKSKPNGYFSHLLGHESEGSVLFFLK 324
Query: 362 KLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLPQKWIF 421
GW ELS+G V +GN+FF ++ +LT GL ++++++V +FQY++++ P+KWI+
Sbjct: 325 HKGWVTELSSGNMRVCQGNSFFILEFELTPEGLQNWKEIVVSVFQYLKLILPEEPKKWIY 384
Query: 422 NELQDISNATFKFKQAGSPSSTVSSLAKCLEK----DYIPVSRILAMGLLTKYEPDLLTQ 477
+E+ +S FKF+Q ++TVSS++ L K YIP IL+ + ++ +
Sbjct: 385 DEISMMSAINFKFRQKADAANTVSSMSNTLYKFAVDGYIPPEYILSSSVYREFNKQEIID 444
Query: 478 YTDALVPENSRVTLISRSLE-TDSAEKWYGTAYKVVDYPADLIKNMKSPGLNPALTLPRP 536
+ L P N +++L+S+SL+ + +EKWYGT Y D P DL++N++S LNP P+P
Sbjct: 445 FGKFLNPNNFKISLVSQSLDGLNKSEKWYGTEYAYEDIPVDLLQNVESAQLNPHFHYPKP 504
Query: 537 NEFVSTNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLPHTHAS 596
N+F+ +F+V + PL P L+ + ++WYK+DD F P+G I + F LP+++
Sbjct: 505 NDFIPKDFEVLRKKSETPLQHPYLIEESNKLQVWYKQDDLFEVPKGNIDIVFHLPNSNLD 564
Query: 597 IINSMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLIILLTRFL 656
S S+L +L D L V Y A+ L++S + G + SG+++KL +LL + L
Sbjct: 565 KKTSTYSSLLAELITDELNQVTYYASLVGLKVSISCWRDGFNVRVSGYSDKLPVLLDQVL 624
Query: 657 QGVNSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKLQVF-E 715
+F+P K+RFE ++ K + KN Y+VPY Q+ + +++NE++++ EK+QV E
Sbjct: 625 SKFFNFKPNKERFEAIRFKLYQQFKNFGYDVPYRQIGTHILSLLNEKTYTYDEKVQVMDE 684
Query: 716 KLTFEQLINFIPTIY--EGVYFETLIHGNIKHEEALEVDSLI----KSLIP--NNIHNLQ 767
L+F++L F G++ E LIHGN + E+ LI KSL P + + ++
Sbjct: 685 DLSFDELNEFATKNLWKSGIFTEVLIHGNFDIAKGDEIRKLIASHTKSLAPIADTLDDVN 744
Query: 768 VSNNRLRSYLLPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSED--LSALSGLFAQLIH 825
+ +L++++LP + RYE L+D +N+NSCI++ Q+ ++D L L+ LF +I
Sbjct: 745 KA-IKLQNFVLPSKEFIRYELPLQDEKNINSCIEYYIQISPTNDDPKLRVLTDLFGTIIR 803
Query: 826 EPCFDTLRTKEQLGYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQ-VLR 884
EPCF+ LRTKEQLGYVVFS + + RIL+QSE T YLE+RI+ F FG+ +
Sbjct: 804 EPCFNQLRTKEQLGYVVFSGTRLGRTSIGFRILVQSERTADYLEYRIDEFLGKFGKHINS 863
Query: 885 DMPEEDFEKHKEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQ 944
++ E DF K K+AL + L K K++ EE++R +I G ++F RQK K++ I+K++
Sbjct: 864 ELTEVDFVKFKQALKDLKLSKLKHLNEETSRLWNSITDGYFDFEARQKHVKILETISKEE 923
Query: 945 MIDFYENYIM--SENASKLILHLKSQ 968
+DF+ NYI S+ + KL+++L SQ
Sbjct: 924 FVDFFNNYIADGSDKSGKLVVYLNSQ 949
>ref|XP_001276340.1| a-pheromone processing metallopeptidase Ste23 [Aspergillus clavatus
NRRL 1]
gb|EAW14914.1| a-pheromone processing metallopeptidase Ste23 [Aspergillus clavatus
NRRL 1]
Length = 1156
Score = 719 bits (1857), Expect = 0.0, Method: Composition-based stats.
Identities = 400/983 (40%), Positives = 593/983 (60%), Gaps = 25/983 (2%)
Query: 3 VSLLASSS---AFVTKPLLTQLVHLSPISLNFTVRRFKPFTCLSRYYTTNPYNMTSNFKT 59
VS LAS++ F + L + L P+ ++T R F C ++ M S +
Sbjct: 31 VSTLASAAIAPPFSSSLRLRPICSLHPLPGSWTRRSFSRSACAP--FSAGNLTMGS-IEH 87
Query: 60 FNLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNLPGLAHF 119
KP+LD+RSYR I LPNKL+ALL+ DP DKA+AS++VN+G F D ++PG+AH
Sbjct: 88 LTESLEKPELDDRSYRVIRLPNKLEALLVHDPDTDKASASVNVNVGNFSDADDMPGMAHA 147
Query: 120 CEHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGALDRFSGFF 179
EHLLFMG++KFP EN Y+ YL+ H GSSNAYTA+ TNYFFE + L+GALDRF+ FF
Sbjct: 148 VEHLLFMGTKKFPKENAYNQYLASHSGSSNAYTAATETNYFFEPSSP-LYGALDRFAQFF 206
Query: 180 SCPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGTL 239
PLF + + D+E+ AV+SENKKNLQ+D+WR+ QL+KSL+N HPYH FSTGN++TL
Sbjct: 207 VSPLFLESTLDRELRAVDSENKKNLQSDLWRLMQLNKSLSNPGHPYHHFSTGNLKTLKED 266
Query: 240 PKENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGREVPLYA 299
P++ GL VR E +KF++ YSAN M+LC+LGRE LD L W +LF +V N +++P
Sbjct: 267 PEKRGLEVRSEFIKFYEKHYSANRMRLCVLGRESLDELEKWVEELFSEVEN--KDLPQNR 324
Query: 300 EPIMQ---PEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGSGSL 356
+Q PE L I +PV D + L+I F D E +ES+P R +SHLIGHEG GS+
Sbjct: 325 WDDVQPWRPEDLGVQIFAKPVMDNRSLDIYFPFLDEEYLYESQPSRYISHLIGHEGPGSI 384
Query: 357 LAHLKKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLP 416
LA++K GWAN LSAG + G+A F + I LT GL YR+V ++F+YI MLK P
Sbjct: 385 LAYIKAKGWANGLSAGVMPICPGSAAFTISIRLTKEGLQQYREVAKVVFEYIAMLKEREP 444
Query: 417 QKWIFNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILAMGLLTKYEPDLLT 476
Q+W+F+E+++++ F+FKQ S S L+ ++K +P +L+ LL K++P+L+
Sbjct: 445 QQWVFDEMKNLAEVEFRFKQKSPASRFTSRLSSVMQKP-MPREWLLSGSLLRKFDPELIK 503
Query: 477 QYTDALVPENSRVTLISRSL--ETDSAEKWYGTAYKVVDYPADLIKNMKSP-GLNP---- 529
+ L P+N R+ ++S+ + DS EKWYGT YKV P D + ++K+ P
Sbjct: 504 KALACLQPDNFRMIVVSQEHPGDWDSKEKWYGTEYKVQKLPQDFMADIKNALATTPETRL 563
Query: 530 -ALTLPRPNEFVSTNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSF 588
L +P NEFV T V+K D +P P L+ D+ +LW+KKDDRFW P+G ++++
Sbjct: 564 SELHMPHENEFVPTRLSVEKKDISEPAKTPKLIRHDEHVRLWFKKDDRFWVPKGTVHITL 623
Query: 589 KLPHTHASIINSMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKL 648
+ P A+ N + S LY +L DAL + YDA A L + + GL I+ G+N+K+
Sbjct: 624 RNPLAWATPANLVKSKLYCELVKDALVEYSYDAELAGLDYHLSASVFGLDISVGGYNDKM 683
Query: 649 IILLTRFLQGVNSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTA 708
+LL + L + DRF I+K++ R +N Y+ P+ Q+ +Y + E++W
Sbjct: 684 AVLLEKVLTSMRDLVVNPDRFHIIKERLSRGYRNAEYQQPFYQVGDYTRHLTAEKTWINE 743
Query: 709 EKLQVFEKLTFEQLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIHNLQV 768
+ E + E + NF P + + + E L HGN+ E+AL + L+++++ +
Sbjct: 744 QYAAELEHIEPEDISNFFPQLLQQNHVEVLAHGNLYKEDALRMTDLVENVLQSRPLPQSQ 803
Query: 769 SNNRLRSYLLPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSED-LSALSGLFAQLIHEP 827
+ R R+ ++P G + YE L+D NVN CI++ + +D L A LFAQ+ EP
Sbjct: 804 WHVR-RNIIIPPGSNYVYERTLQDPANVNHCIEYYVYVGSIRDDILRAKLLLFAQMTDEP 862
Query: 828 CFDTLRTKEQLGYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVLRDMP 887
FD LR+KEQLGYVV+S + + T R++IQSE T YLE RI+NF G+ L +M
Sbjct: 863 AFDQLRSKEQLGYVVWSGARYSATTIGYRVIIQSERTAEYLESRIDNFLIQAGETLENMS 922
Query: 888 EEDFEKHKEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMID 947
++DFE HK ++ N L+K KN++ E++R+ + I ++F + A V +TK ++D
Sbjct: 923 DKDFEGHKRSVVNKRLEKLKNLSSETSRFWSHIGSEYFDFVQNETDAANVRTLTKADIVD 982
Query: 948 FYENYI--MSENASKLILHLKSQ 968
FY+ I S KL ++L +Q
Sbjct: 983 FYKQLIDPRSPTRGKLSIYLNAQ 1005
>ref|XP_759404.1| hypothetical protein UM03257.1 [Ustilago maydis 521]
gb|EAK84184.1| hypothetical protein UM03257.1 [Ustilago maydis 521]
Length = 1292
Score = 718 bits (1853), Expect = 0.0, Method: Composition-based stats.
Identities = 377/934 (40%), Positives = 572/934 (61%), Gaps = 17/934 (1%)
Query: 47 TTNPYNMTSNFKTFNLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGA 106
T N + + F D D+ YR + L N L+AL+IQDPK DK++A++D+ +G
Sbjct: 198 TLNGSKAAAQYAVFTKDLEVSAQDDLRYRLVRLANGLEALVIQDPKTDKSSAAMDIRVGH 257
Query: 107 FEDPKNLPGLAHFCEHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQ 166
DP+ L GLAHFCEHLLFMG++K+P ENEYS YLS H G SNAYT NTNYFF+V+
Sbjct: 258 LSDPEELQGLAHFCEHLLFMGTKKYPRENEYSEYLSNHSGGSNAYTGMDNTNYFFDVSPD 317
Query: 167 HLFGALDRFSGFFSCPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYH 226
H GALDRF+ FF PLF+ +++EI AV+SE+KKNLQ+D+WR +QLDKSL++ HPY
Sbjct: 318 HFEGALDRFAQFFLEPLFDPSCSEREIKAVDSEHKKNLQSDMWRGFQLDKSLSDPSHPYS 377
Query: 227 KFSTGNIETLGTLPKENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFK 286
F TGN +TL PK G++VRDELLKFH +YSAN+MKL +LGREDLD L+ W + F
Sbjct: 378 HFGTGNYQTLWEDPKSKGVDVRDELLKFHDQYYSANVMKLVVLGREDLDQLTSWVIEKFS 437
Query: 287 DVANNGREVPLYAEPIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSH 346
V N GRE P + + + LQK I + V+D++KL+I+F +PD H+ SKP LSH
Sbjct: 438 GVRNTGREPPQFDRSPLTTQQLQKQIFAKSVRDVRKLKIAFPIPDQGPHFRSKPGHFLSH 497
Query: 347 LIGHEGSGSLLAHLKKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQ 406
IGHEG GS+L+HLKK GW + LSAG + G FF + IDLT GL ++ V+ +F+
Sbjct: 498 FIGHEGEGSILSHLKKKGWCDRLSAGATGDANGFEFFKISIDLTQEGLDNHEKVVEAVFK 557
Query: 407 YIEMLKNSLPQKWIFNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILAMGL 466
YI +L++S ++W +E+ +S F+FK+ P+ SS A ++ Y P IL+ G
Sbjct: 558 YIHLLRSSNLEQWTHDEVAQLSELMFRFKEKIDPADYASSTATQMQMPY-PREWILSGGW 616
Query: 467 LTK-YEPDLLTQYTDALVPENSRVTLISRSLET-----DSAEKWYGTAYKVVDYPADLIK 520
LT+ ++ +L+TQ D L P+N RV +++++L +S EKWYGT Y + P L+
Sbjct: 617 LTRDFDRELITQTLDHLTPQNCRVVVMAKTLPDGSTSWESKEKWYGTEYSIKPLPQQLL- 675
Query: 521 NMKSPGLNPALTLPRPNEFVSTNFK----VDKIDGIKPLDEPVLLLSDDVSKLWYKKDDR 576
++P L LPRPN F+ NF + + G KP P L+L ++ ++W+K DDR
Sbjct: 676 -TQTPADFEDLHLPRPNSFIPVNFDFKGPLAEAQGKKPTPRPQLVLDNESIRVWHKLDDR 734
Query: 577 FWQPRGYIYLSFKLPHTHASIINSMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQG 636
F P+ ++ + P +A+ + S+ + + +L +D+L + YDA+ A L + +Q
Sbjct: 735 FGLPKANVFFVLRNPLINATPLTSIKTRMLIELISDSLVEYSYDASLAGLSYMLDSQDQS 794
Query: 637 LAITASGFNEKLIILLTRFLQGVNSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYY 696
LA++ SG+N+K+ +L L+ + +F+ RFE++KD+ R +N E PY + Y
Sbjct: 795 LALSLSGYNDKIPVLARSILEKLANFQVDPRRFELVKDRVKRSYQNFAIEEPYRHATFYT 854
Query: 697 NAIINERSWSTAEKLQVFEKLTFEQLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIK 756
++ E+ W+ EKL E+L +++ F+P + + ++ E L HGN+ EEA+E+ ++
Sbjct: 855 TYLLQEKMWTPQEKLCELEQLNVDEVQQFLPDLLQRMHLEVLAHGNLAKEEAIELSNMAW 914
Query: 757 SLIPNNIHNLQVSNNRLRSYLLPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSE-DLSA 815
+ I + N + RS LLP+ + + ++ NVNS I++ Q+ ++ ++ A
Sbjct: 915 NTIKSRPVN-KTELLSSRSLLLPEKSNKIWNLPVTNAANVNSAIEYYVQIGEPTDVEMRA 973
Query: 816 LSGLFAQLIHEPCFDTLRTKEQLGYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNF 875
LF+Q+ +EP FD LRTKEQLGY+VFS + G+ R+++QSE PYLE R++ F
Sbjct: 974 TLSLFSQIANEPVFDQLRTKEQLGYLVFSGIRRSTGSLGWRVIVQSERDAPYLEGRVDAF 1033
Query: 876 YETFGQVLRDMPEEDFEKHKEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAK 935
+ F L M E++FE HK ++ + L+ KN+ EES R+ + ++ G+Y+F R +
Sbjct: 1034 LDQFRATLDKMTEQEFEAHKRSIIHKKLENVKNLVEESTRFWSPVFGGNYDFLARYADVE 1093
Query: 936 LVANITKQQMIDFYENYI--MSENASKLILHLKS 967
+A TK+Q++D + YI S SKL +HL S
Sbjct: 1094 AIAQTTKEQVVDLFMKYIHPSSPTRSKLSVHLNS 1127
>ref|XP_748141.1| a-pheromone processing metallopeptidase Ste23 [Aspergillus fumigatus
Af293]
gb|EAL86103.1| a-pheromone processing metallopeptidase Ste23 [Aspergillus fumigatus
Af293]
Length = 1154
Score = 715 bits (1846), Expect = 0.0, Method: Composition-based stats.
Identities = 383/917 (41%), Positives = 569/917 (62%), Gaps = 19/917 (2%)
Query: 66 KPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNLPGLAHFCEHLLF 125
KP+LD+RSYR I L NKL+ALL+ DP+ DKA+AS++VN+G F D ++PG+AH EHLLF
Sbjct: 93 KPELDDRSYRVIRLSNKLEALLVHDPETDKASASVNVNVGNFSDADDMPGMAHAVEHLLF 152
Query: 126 MGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGALDRFSGFFSCPLFN 185
MG++KFP EN Y+ YL+ H GSSNAYTA+ TNYFFE + L+GALDRF+ FF PLF
Sbjct: 153 MGTKKFPKENAYNQYLASHSGSSNAYTAATETNYFFEPSSP-LYGALDRFAQFFVSPLFL 211
Query: 186 KDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGTLPKENGL 245
+ + D+E+ AV+SENKKNLQ+D+WR+ QL+KSL+N HPYH FSTGN++TL P++ GL
Sbjct: 212 ESTLDRELRAVDSENKKNLQSDLWRLMQLNKSLSNPAHPYHHFSTGNLKTLKEDPQQRGL 271
Query: 246 NVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGREVPLYAEPIMQP 305
VR E +KF++ YSAN MKLC+LGRE LD L W +LF +V N +++P +QP
Sbjct: 272 EVRSEFIKFYQKHYSANRMKLCVLGRESLDELEKWVEELFSEVEN--KDLPQNRWDDVQP 329
Query: 306 ---EHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGSGSLLAHLKK 362
E L I +PV D + L+I F D E +ES+P R +SHLIGHEG GS+LA++K
Sbjct: 330 WRHEDLGIQIFAKPVMDTRSLDIYFPFLDEETLYESQPSRYISHLIGHEGPGSILAYIKA 389
Query: 363 LGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLPQKWIFN 422
GWAN LSAG + G A F + I LT GL YR+V ++FQYI MLK PQ+W+F+
Sbjct: 390 KGWANGLSAGVMPICPGAAAFTISIRLTKEGLQQYREVAKVVFQYIAMLKEREPQQWVFD 449
Query: 423 ELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILAMGLLTKYEPDLLTQYTDAL 482
E+++++ F+FKQ S S L+ ++K +P +L+ LL K++PDL+ + L
Sbjct: 450 EMKNMAEVEFRFKQKSPASRFTSRLSSVMQKP-LPREWLLSGSLLRKFDPDLIKKALSYL 508
Query: 483 VPENSRVTLISRSL--ETDSAEKWYGTAYKVVDYPADLIKNMK-----SPGLNPA-LTLP 534
P+N R+ ++S+ + DS EKWYGT YKV P D + +++ +P + L +P
Sbjct: 509 RPDNFRLIVVSQEYPGDWDSKEKWYGTEYKVGKIPEDFMADIREALDTTPETRLSDLHMP 568
Query: 535 RPNEFVSTNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLPHTH 594
NEFV T V+K + +P P L+ DD +LW+KKDDRFW P+G ++++ + P
Sbjct: 569 HKNEFVPTRLSVEKKEVSEPAKTPKLIRHDDHVRLWFKKDDRFWVPKGTVHITLRNPLAW 628
Query: 595 ASIINSMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLIILLTR 654
A+ N + S LY +L DAL + YDA A L + + GL ++ G+N+K+ +LL +
Sbjct: 629 ATPANLVKSKLYCELVKDALVEYSYDAELAGLDYHLSASVFGLDVSVGGYNDKMAVLLEK 688
Query: 655 FLQGVNSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKLQVF 714
+ +RF I+K++ R +N Y+ P+ Q+ +Y + +E++W +
Sbjct: 689 VFTSMRDLVVNPNRFHIIKERLSRGYRNAEYQQPFYQVGDYTRYLTSEKTWINEQYAAEL 748
Query: 715 EKLTFEQLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIHNLQVSNNRLR 774
E + E + +F P + + E L HGN+ E+AL++ L+++++ + + R R
Sbjct: 749 EHIEAEDISSFFPQLLSQNHIEVLAHGNLYKEDALKMTDLVENILQSRPLPQSQWHVR-R 807
Query: 775 SYLLPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSED-LSALSGLFAQLIHEPCFDTLR 833
+ ++P G F YE L+D N+N CI++ + ++D L A LFAQ+ EP FD LR
Sbjct: 808 NIIIPPGSNFIYERTLRDPANINHCIEYYVYVGSITDDMLRAKLLLFAQMTDEPAFDQLR 867
Query: 834 TKEQLGYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVLRDMPEEDFEK 893
+KEQLGYVV+S + + T R++IQSE T YLE RI+NF G+ L +M E+DFE
Sbjct: 868 SKEQLGYVVWSGARYSATTIGYRVIIQSERTAEYLESRIDNFLIQTGETLENMSEKDFEG 927
Query: 894 HKEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMIDFYENYI 953
HK ++ N L+K KN++ E++R+ + I ++F + A V +TK ++DFY+ I
Sbjct: 928 HKRSVINKRLEKLKNLSSETSRFWSHIGSEYFDFLQNESDAANVRALTKADIVDFYKQLI 987
Query: 954 --MSENASKLILHLKSQ 968
S KL ++L +Q
Sbjct: 988 DPRSPTRGKLSIYLNAQ 1004
>gb|EDP51051.1| a-pheromone processing metallopeptidase Ste23 [Aspergillus fumigatus
A1163]
Length = 1154
Score = 715 bits (1845), Expect = 0.0, Method: Composition-based stats.
Identities = 382/917 (41%), Positives = 569/917 (62%), Gaps = 19/917 (2%)
Query: 66 KPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNLPGLAHFCEHLLF 125
KP+LD+RSYR I L NKL+ALL+ DP+ DKA+AS++VN+G F D ++PG+AH EHLLF
Sbjct: 93 KPELDDRSYRVIRLSNKLEALLVHDPETDKASASVNVNVGNFSDADDMPGMAHAVEHLLF 152
Query: 126 MGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGALDRFSGFFSCPLFN 185
MG++KFP EN Y+ YL+ H GSSNAYTA+ TNYFFE + L+GALDRF+ FF PLF
Sbjct: 153 MGTKKFPKENAYNQYLASHSGSSNAYTAATETNYFFEPSSP-LYGALDRFAQFFVSPLFL 211
Query: 186 KDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGTLPKENGL 245
+ + D+E+ AV+SENKKNLQ+D+WR+ QL+KSL+N HPYH FSTGN++TL P++ GL
Sbjct: 212 ESTLDRELRAVDSENKKNLQSDLWRLMQLNKSLSNPAHPYHHFSTGNLKTLKEDPQQRGL 271
Query: 246 NVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGREVPLYAEPIMQP 305
VR E +KF++ YSAN MKLC+LGRE LD L W +LF +V N +++P +QP
Sbjct: 272 EVRSEFIKFYQKHYSANRMKLCVLGRESLDELEKWVEELFSEVEN--KDLPQNRWDDVQP 329
Query: 306 ---EHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGSGSLLAHLKK 362
E L I +PV D + ++I F D E +ES+P R +SHLIGHEG GS+LA++K
Sbjct: 330 WRHEDLGIQIFAKPVMDTRSVDIYFPFLDEETLYESQPSRYISHLIGHEGPGSILAYIKA 389
Query: 363 LGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLPQKWIFN 422
GWAN LSAG + G A F + I LT GL YR+V ++FQYI MLK PQ+W+F+
Sbjct: 390 KGWANGLSAGVMPICPGAAAFTISIRLTKEGLQQYREVAKVVFQYIAMLKEREPQQWVFD 449
Query: 423 ELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILAMGLLTKYEPDLLTQYTDAL 482
E+++++ F+FKQ S S L+ ++K +P +L+ LL K++PDL+ + L
Sbjct: 450 EMKNLAEVEFRFKQKSPASRFTSRLSSVMQKP-LPREWLLSGSLLRKFDPDLIKKALSYL 508
Query: 483 VPENSRVTLISRSL--ETDSAEKWYGTAYKVVDYPADLIKNMK-----SPGLNPA-LTLP 534
P+N R+ ++S+ + DS EKWYGT YKV P D + +++ +P + L +P
Sbjct: 509 RPDNFRLIVVSQEYPGDWDSKEKWYGTEYKVGKIPEDFMADIREALDTTPETRLSDLHMP 568
Query: 535 RPNEFVSTNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLPHTH 594
NEFV T V+K + +P P L+ DD +LW+KKDDRFW P+G ++++ + P
Sbjct: 569 HKNEFVPTRLSVEKKEVSEPAKTPKLIRHDDHVRLWFKKDDRFWVPKGTVHITLRNPLAW 628
Query: 595 ASIINSMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLIILLTR 654
A+ N + S LY +L DAL + YDA A L + + GL ++ G+N+K+ +LL +
Sbjct: 629 ATPANLVKSKLYCELVKDALVEYSYDAELAGLDYHLSASVFGLDVSVGGYNDKMAVLLEK 688
Query: 655 FLQGVNSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKLQVF 714
+ +RF I+K++ R +N Y+ P+ Q+ +Y + +E++W +
Sbjct: 689 VFTSMRDLVVNPNRFHIIKERLSRGYRNAEYQQPFYQVGDYTRYLTSEKTWINEQYAAEL 748
Query: 715 EKLTFEQLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIHNLQVSNNRLR 774
E + E + +F P + + E L HGN+ E+AL++ L+++++ + + R R
Sbjct: 749 EHIEAEDISSFFPQLLSQNHIEVLAHGNLYKEDALKMTDLVENILQSRPLPQSQWHVR-R 807
Query: 775 SYLLPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSED-LSALSGLFAQLIHEPCFDTLR 833
+ ++P G F YE L+D N+N CI++ + ++D L A LFAQ+ EP FD LR
Sbjct: 808 NIIIPPGSNFIYERTLRDPANINHCIEYYVYVGSITDDMLRAKLLLFAQMTDEPAFDQLR 867
Query: 834 TKEQLGYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVLRDMPEEDFEK 893
+KEQLGYVV+S + + T R++IQSE T YLE RI+NF G+ L +M E+DFE
Sbjct: 868 SKEQLGYVVWSGARYSATTIGYRVIIQSERTAEYLESRIDNFLIQTGETLENMSEKDFEG 927
Query: 894 HKEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMIDFYENYI 953
HK ++ N L+K KN++ E++R+ + I ++F + A V +TK ++DFY+ I
Sbjct: 928 HKRSVINKRLEKLKNLSSETSRFWSHIGSEYFDFLQNESDAANVRALTKADIVDFYKQLI 987
Query: 954 --MSENASKLILHLKSQ 968
S KL ++L +Q
Sbjct: 988 DPRSPTRGKLSIYLNAQ 1004
>ref|XP_001242515.1| hypothetical protein CIMG_06411 [Coccidioides immitis RS]
gb|EAS30932.1| hypothetical protein CIMG_06411 [Coccidioides immitis RS]
Length = 1126
Score = 714 bits (1843), Expect = 0.0, Method: Composition-based stats.
Identities = 391/964 (40%), Positives = 576/964 (59%), Gaps = 66/964 (6%)
Query: 66 KPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNLPGLAHFCEHLLF 125
KP +D+RSYR I L NKL+ALL+ DP DKA+AS++VN+G F D ++PG+AH EHLLF
Sbjct: 12 KPVVDDRSYRVIRLANKLEALLVHDPNTDKASASVNVNVGNFSDDDDMPGMAHAVEHLLF 71
Query: 126 MGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEV---NHQH--------------- 167
MG+EK+P EN+Y+ YL+ H G SNAYTA+ TNY+FEV +H
Sbjct: 72 MGTEKYPGENDYNQYLAAHSGHSNAYTAATETNYYFEVAATSHSQPVESPQSALPTPSEN 131
Query: 168 ----------------------------LFGALDRFSGFFSCPLFNKDSTDKEINAVNSE 199
LFGALDRF+ FF CPLF + D+E+ AV+SE
Sbjct: 132 PTPLGPLVDRRSSTVEESASTTSDPESPLFGALDRFAQFFICPLFLPSTLDRELRAVDSE 191
Query: 200 NKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGTLPKENGLNVRDELLKFHKNFY 259
NKKNLQ+D WR+ QL+KSL+N KHPYH FSTGN++TL P++ GL+VR+E ++FH+ Y
Sbjct: 192 NKKNLQSDPWRLLQLNKSLSNPKHPYHHFSTGNLQTLRDEPQKRGLDVREEFIRFHEKHY 251
Query: 260 SANLMKLCILGREDLDTLSDWTYDLFKDVANNGREVPLYA---EPIMQPEHLQKIIQVRP 316
SAN MKL +LGRE LD L W LF DV N +E+P P PE +QK+I +P
Sbjct: 252 SANRMKLVVLGRESLDQLERWVVQLFSDVKN--KELPQNRWDDVPPFAPEDMQKMIYAKP 309
Query: 317 VKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGSGSLLAHLKKLGWANELSAGGHTV 376
V D + L+I F D E ++S+P R +SHLIGHEG GS+LA++K GWA ELSAG V
Sbjct: 310 VMDTRSLDIFFVYQDEEHMYDSQPSRYISHLIGHEGPGSILAYIKAKGWATELSAGAMPV 369
Query: 377 SKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLPQKWIFNELQDISNATFKFKQ 436
G AFF + I LT++GL H+++V ++FQYI ++K + P++WIF+E++++S F+FKQ
Sbjct: 370 CPGAAFFNISIRLTEDGLHHHQEVAKVVFQYIALIKENPPEQWIFDEMKNLSEVDFRFKQ 429
Query: 437 AGSPSSTVSSLAKCLEKDYIPVSRILAMGLLTKYEPDLLTQYTDALVPENSRVTLISRSL 496
S SSL+ ++K Y P +++ LL +++P+L+T+ L +N + LIS++
Sbjct: 430 KSPASRFTSSLSSVMQKPY-PREWLISCSLLRRFDPELVTRGLSYLNADNFNIELISQTY 488
Query: 497 --ETDSAEKWYGTAYKVVDYPADLIKNMK------SPGLNPALTLPRPNEFVSTNFKVDK 548
+ D EKWYGT Y+V P +L+ ++ S G P L LP NEFV T V+K
Sbjct: 489 PGDWDRREKWYGTEYRVEKVPEELLSEIRAMLESPSAGKIPELHLPHKNEFVPTRLDVEK 548
Query: 549 IDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLPHTHASIINSMLSTLYTQ 608
+ KP P L+ +D+ ++W+KKDD FW P+ + ++ + P +A+ N++ + LY +
Sbjct: 549 KEVDKPTQTPSLIRNDERVRVWFKKDDTFWVPKASLEITLRNPLVYATPGNNVKARLYCE 608
Query: 609 LANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLIILLTRFLQGVNSFEPKKDR 668
L DAL + YDA A L + GL ++ G+N+K+ +LL + L + E K DR
Sbjct: 609 LVRDALTEYSYDAELAGLEYDLVPSVFGLDVSIIGYNDKMAVLLEKVLHSMKDLEVKPDR 668
Query: 669 FEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKLQVFEKLTFEQLINFIPT 728
F I+K++ R +N Y++PY Q+ NY + E+++ + + E + E + F P
Sbjct: 669 FRIVKERLTRGFRNAEYQLPYYQVGNYTRFLTAEKAFINQQLAEELEHIEAEDVATFFPQ 728
Query: 729 IYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIHNLQVSNNRL-RSYLLPKGKTFRYE 787
+ + E L HGN+ E+AL++ L++S + L S R+ R+ +LP G + YE
Sbjct: 729 LLRQTHIEVLAHGNLYKEDALQLTDLVESTFKS--RPLPRSQWRVRRNMILPPGSNYIYE 786
Query: 788 TALKDSQNVNSCIQHVTQLDVYSED-LSALSGLFAQLIHEPCFDTLRTKEQLGYVVFSSS 846
LKD N+N CI++ + ++ L A LFAQ+ EP FD LRTKEQLGYVV+S +
Sbjct: 787 YTLKDPANINHCIEYYLFVGSLTDPVLRAKIQLFAQMASEPAFDQLRTKEQLGYVVWSGA 846
Query: 847 LNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVLRDMPEEDFEKHKEALCNSLLQKF 906
+ T R++IQSE YLE RI+ F F L DM + FE HK ++ N L+K
Sbjct: 847 RYSATTLGYRVIIQSERDCDYLESRIDAFLSRFANYLNDMTDSVFEAHKRSVINKRLEKM 906
Query: 907 KNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMIDFYENYI--MSENASKLILH 964
KN++ E+ RY + I Y++ + A+ V +TK ++++FY YI S + +KL +H
Sbjct: 907 KNLSSETNRYWSHIGSEYYDYLQHETDAEAVRPLTKAEIVEFYRQYIDPQSPSRAKLAVH 966
Query: 965 LKSQ 968
+K+Q
Sbjct: 967 MKAQ 970
>ref|XP_001801272.1| hypothetical protein SNOG_11020 [Phaeosphaeria nodorum SN15]
gb|EAT81519.2| hypothetical protein SNOG_11020 [Phaeosphaeria nodorum SN15]
Length = 1098
Score = 714 bits (1842), Expect = 0.0, Method: Composition-based stats.
Identities = 395/966 (40%), Positives = 561/966 (58%), Gaps = 40/966 (4%)
Query: 63 DFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNLPGLAHFCEH 122
D +P LD+RSYR I L N+L+ LLI + DKA+A+LDVN+G+F D ++PG+AH EH
Sbjct: 15 DLERPQLDDRSYRVITLQNQLEVLLIHEAGTDKASAALDVNVGSFNDADDMPGIAHAVEH 74
Query: 123 LLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEV------------------- 163
LLFMG+EK+P+EN Y+ YL+ HGG SNA+TAS +TNY+FE+
Sbjct: 75 LLFMGTEKYPEENAYNKYLTTHGGHSNAFTASTSTNYYFELSYPSSSPSNSKAATPSAST 134
Query: 164 ---------NHQHLFGALDRFSGFFSCPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQL 214
++ L+GALDRF FF PLF +D+ D+EI AV+SENKKNLQ+D WR++QL
Sbjct: 135 VNLSASKEKDNSPLWGALDRFGQFFIAPLFLEDTLDREIKAVDSENKKNLQSDQWRLHQL 194
Query: 215 DKSLTNTKHPYHKFSTGNIETLGTLPKENGLNVRDELLKFHKNFYSANLMKLCILGREDL 274
+K+L N HPY FSTG+ +TL P G+ +RDE +KFH YSAN MKL +LGRE L
Sbjct: 195 NKALANPNHPYCHFSTGSWKTLHDDPIARGVKIRDEFIKFHSTNYSANRMKLVVLGRESL 254
Query: 275 DTLSDWTYDLFKDVANNGREVPLYAEPIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEE 334
DTL +W ++FK V N + P+ L +PV + + LEI F D E+
Sbjct: 255 DTLEEWVEEIFKKVPNKDLSRRSWDIPVYTENELLTQTFAKPVLESRSLEIQFAYRDEED 314
Query: 335 HWESKPPRILSHLIGHEGSGSLLAHLKKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGL 394
+ES+P R LSHLIGHEG GS+LAH+K GWAN L AGG T+ G+ F++ + LT+ GL
Sbjct: 315 LYESQPSRYLSHLIGHEGPGSILAHIKAKGWANGLGAGGSTLCPGSGLFSISVKLTEEGL 374
Query: 395 THYRDVIVLIFQYIEMLKNSLPQKWIFNELQDISNATFKFKQAGSPSSTVSSLAKCLEKD 454
+Y++V ++FQYI M++ PQKWI +E IS F+FKQ PS T SSLA ++K
Sbjct: 375 KNYKEVAKIVFQYIGMMREKEPQKWIVDEQMRISEVEFRFKQKSPPSRTASSLAGIMQKP 434
Query: 455 YIPVSRILAMGLLTKYEPDLLTQYTDALVPENSRVTLISRSLET--DSAEKWYGTAYKVV 512
Y + ++ K++ + + L P+N R+T++S+ D EKWYGT +KV
Sbjct: 435 YDRKMLLSGPAVIRKFDSQRINEALSYLRPDNFRMTIVSQDFPGGWDRKEKWYGTEHKVE 494
Query: 513 DYPADLIKNMK----SPGLNPALTLPRPNEFVSTNFKVDKIDGIKPLDEPVLLLSDDVSK 568
D + +K S + L P NEF+ + V+K + +P EP L+ DD +
Sbjct: 495 KLSEDFLAEIKAAFESKERSAELHFPHKNEFIPSRLDVEKKEITQPSKEPKLIRHDDNVR 554
Query: 569 LWYKKDDRFWQPRGYIYLSFKLPHTHASIINSMLSTLYTQLANDALKDVQYDAACADLRI 628
+W+KKDD+FW P+ +++ + P T+ + +++STLY +L DAL + YDA + L
Sbjct: 555 IWWKKDDQFWVPKANVHIYLRTPITNVTPRVALMSTLYRELVTDALVEYSYDADISGLVY 614
Query: 629 SFNKTNQGLAITASGFNEKLIILLTRFLQGVNSFEPKKDRFEILKDKTIRHLKNLLYEVP 688
F G+++T SG+N+KL +LL + L + E K+DRF+I++++ R L+N Y P
Sbjct: 615 DFTNHANGISVTVSGYNDKLHVLLEKVLTSLRDLEIKQDRFDIIRERITRSLRNWDYGQP 674
Query: 689 YSQMSNYYNAIINERSWSTAEKLQVFEKLTFEQLINFIPTIYEGVYFETLIHGNIKHEEA 748
+ Q+ Y A NE+SW + + + +T E + F P I E L HGN+ EEA
Sbjct: 675 FHQVGTYSRAFKNEKSWMNEDLAKELDSVTAEDVRQFYPQILAQGLIEVLAHGNLYKEEA 734
Query: 749 LEVDSLI-KSLIPNNIHNLQVSNNRLRSYLLPKGKTFRYETALKDSQNVNSCIQH-VTQL 806
L+ L+ ++L P + Q+ R+ + P G F YE LKD NVN CI++ +
Sbjct: 735 LKFTDLVERTLRPKKLAANQIPIR--RNLMWPTGCNFIYEKQLKDPANVNHCIEYSLYAG 792
Query: 807 DVYSEDLSALSGLFAQLIHEPCFDTLRTKEQLGYVVFSSSLNNHGTANIRILIQSEHTTP 866
D + A L Q+ EPCF+ LRT EQLGYVVFS A RILIQSE
Sbjct: 793 DDRENNTRAKLMLLTQMTDEPCFNQLRTIEQLGYVVFSGQSFADTWAGYRILIQSEKDCR 852
Query: 867 YLEWRINNFYETFGQVLRDMPEEDFEKHKEALCNSLLQKFKNMAEESARYTAAIYLGDYN 926
YLE RI NF TF + L++M E DFE HK A+ L K KN+++E R+ IY Y+
Sbjct: 853 YLEGRIENFLNTFEKALQEMSESDFEDHKRAMITKRLTKLKNLSQEDMRFWNHIYSDAYD 912
Query: 927 FTHRQKKAKLVANITKQQMIDFYENYI--MSENASKLILHLKSQVENKELNENELDTAKY 984
F A+ + ITK+ M+DFY YI S SKL +HL++Q + KE +E +
Sbjct: 913 FLLADTDAENLDKITKKDMVDFYAQYISPSSSKRSKLSVHLQAQSKPKEPTLDEKKKSAL 972
Query: 985 PTGQLI 990
Q+I
Sbjct: 973 AAVQVI 978
>ref|XP_001266332.1| a-pheromone processing metallopeptidase Ste23 [Neosartorya fischeri
NRRL 181]
gb|EAW24435.1| a-pheromone processing metallopeptidase Ste23 [Neosartorya fischeri
NRRL 181]
Length = 1155
Score = 714 bits (1842), Expect = 0.0, Method: Composition-based stats.
Identities = 381/917 (41%), Positives = 567/917 (61%), Gaps = 19/917 (2%)
Query: 66 KPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNLPGLAHFCEHLLF 125
KP+LD+RSYR I L NKL+ALL+ DP+ DKA+AS++VN+G F D ++PG+AH EHLLF
Sbjct: 94 KPELDDRSYRVIRLSNKLEALLVHDPETDKASASVNVNVGNFSDADDMPGMAHAVEHLLF 153
Query: 126 MGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGALDRFSGFFSCPLFN 185
MG++KFP EN Y+ YL+ H GSSNAYTA+ TNYFFE + L+GALDRF+ FF PLF
Sbjct: 154 MGTKKFPKENAYNQYLASHSGSSNAYTAATETNYFFEPSSP-LYGALDRFAQFFVSPLFL 212
Query: 186 KDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGTLPKENGL 245
+ + D+E+ AV+SENKKNLQ+D+WR+ QL+KSL+N HPYH FSTGN++TL P++ GL
Sbjct: 213 ESTLDRELRAVDSENKKNLQSDLWRLMQLNKSLSNPAHPYHHFSTGNLKTLKEDPQQRGL 272
Query: 246 NVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGREVPLYAEPIMQP 305
VR E +KF++ YSAN M+LC+LGRE LD L W +LF +V N +++P +QP
Sbjct: 273 EVRSEFIKFYQKHYSANRMRLCVLGRESLDELEKWVEELFSEVEN--KDLPQNRWDDVQP 330
Query: 306 ---EHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGSGSLLAHLKK 362
E L I +PV D + L+I F D E +ES+P R +SHLIGHEG GS+LA++K
Sbjct: 331 WRDEDLGIQIFAKPVMDTRSLDIYFPFLDEETLYESQPSRYISHLIGHEGPGSILAYIKA 390
Query: 363 LGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLPQKWIFN 422
GWAN LSAG + G A F + I LT GL YR+V ++FQYI MLK PQ+W+F+
Sbjct: 391 KGWANGLSAGVMPICPGAAAFTISIRLTKEGLQQYREVAKVVFQYIAMLKEREPQQWVFD 450
Query: 423 ELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILAMGLLTKYEPDLLTQYTDAL 482
E+++++ F+FKQ S S L+ ++K +P +L+ LL K++PDL+ + L
Sbjct: 451 EMKNLAEVEFRFKQKSPASRFTSRLSSVMQKP-LPREWLLSGSLLRKFDPDLIKKALSYL 509
Query: 483 VPENSRVTLISRSLETD--SAEKWYGTAYKVVDYPADLIKNMK-----SPGLN-PALTLP 534
P+N R+ ++S+ D S EKWYGT YKV P D + +++ +P L +P
Sbjct: 510 RPDNFRLIVVSQEYPGDWNSKEKWYGTEYKVGKIPQDFMADIREALDSTPETRLSELHMP 569
Query: 535 RPNEFVSTNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLPHTH 594
NEFV T V+K + +P P L+ DD +LW+KKDDRFW P+G ++++ + P
Sbjct: 570 HKNEFVPTRLSVEKKEVAEPAKTPKLIRHDDHVRLWFKKDDRFWVPKGTVHITLRNPLAW 629
Query: 595 ASIINSMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLIILLTR 654
A+ N + S LY +L DAL + YDA A L + + GL ++ G+N+K+ +LL +
Sbjct: 630 ATPANLVKSKLYCELVKDALVEYSYDAELAGLDYHLSASVFGLDVSVGGYNDKMAVLLEK 689
Query: 655 FLQGVNSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKLQVF 714
+ +RF I+K++ R +N Y+ P+ Q+ +Y + +E++W +
Sbjct: 690 VFTSMRDLVVNPNRFHIIKERLSRGYRNAEYQQPFYQVGDYTRYLTSEKTWINEQYAAEL 749
Query: 715 EKLTFEQLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIHNLQVSNNRLR 774
E + E + NF P + + E L HGN+ E+AL++ L+++++ + + R R
Sbjct: 750 EHIDAEDISNFFPQLLSQNHIEVLAHGNLYKEDALKMTDLVENILQSRPLPQSQWHVR-R 808
Query: 775 SYLLPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSED-LSALSGLFAQLIHEPCFDTLR 833
+ ++P G + YE L+D N+N CI++ + ++D L A LFAQ+ EP FD LR
Sbjct: 809 NIIIPPGSNYVYERTLRDPANINHCIEYYVYVGSITDDMLRAKLLLFAQMTDEPAFDQLR 868
Query: 834 TKEQLGYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVLRDMPEEDFEK 893
+KEQLGYVV+S + + T R++IQSE T YLE RI+NF G+ L +M E+DFE
Sbjct: 869 SKEQLGYVVWSGARYSATTIGYRVIIQSERTAEYLESRIDNFLIQTGETLENMSEKDFEG 928
Query: 894 HKEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMIDFYENYI 953
HK ++ N L+K KN++ E++R+ + I ++F + A V +TK ++DFY+ +
Sbjct: 929 HKRSVINKRLEKLKNLSSETSRFWSHIGSEYFDFLQNESDAANVRALTKADIVDFYKQLL 988
Query: 954 --MSENASKLILHLKSQ 968
S KL ++L +Q
Sbjct: 989 DPRSPTRGKLSIYLNAQ 1005
>ref|XP_001506502.1| PREDICTED: similar to insulin-degrading enzyme [Ornithorhynchus
anatinus]
Length = 1301
Score = 714 bits (1842), Expect = 0.0, Method: Composition-based stats.
Identities = 374/963 (38%), Positives = 575/963 (59%), Gaps = 22/963 (2%)
Query: 63 DFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNLPGLAHFCEH 122
+ +K D+R YR +EL N +KA+LI DP DK++A+LDV+IG+ DP N+ GL+HFCEH
Sbjct: 335 NIIKSPEDKREYRGLELANGIKAILISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEH 394
Query: 123 LLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGALDRFSGFFSCP 182
+LF+G++K+P ENEYS +LS+H GSSNA+T+ ++TNY+F+V+H+HL GALDRF+ FF CP
Sbjct: 395 MLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCP 454
Query: 183 LFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGTLPKE 242
LF++ D+E+NAV+SE++KN+ ND WR++QL+K+ N HP+ KF TGN TL T P +
Sbjct: 455 LFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPNHPFSKFGTGNKYTLETRPTK 514
Query: 243 NGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGREVPLYAEPI 302
G++VR ELLKFH +YS+NLM +C+LGRE LD L+ LF +V N +P + E
Sbjct: 515 EGIDVRQELLKFHSTYYSSNLMAICVLGRESLDELTSLVVKLFSEVENKNVPLPEFPEHP 574
Query: 303 MQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGSGSLLAHLKK 362
Q HL++I +V P+KD++ L ++F +PD++++++S P L HLIGHEG GSLL+ LK
Sbjct: 575 FQEHHLRQIYKVVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKA 634
Query: 363 LGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLPQKWIFN 422
GW N L G ++G FF +++DLT+ GL H D+I+ +FQYI+ L+ PQ+W+F
Sbjct: 635 KGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRTEGPQEWVFQ 694
Query: 423 ELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILAMG-LLTKYEPDLLTQYTDA 481
E +D++ F+FK P S L L Y P+ +LA LL ++ PDL+ D
Sbjct: 695 ECKDLNAVAFRFKDKERPRGYTSKLGGMLH--YYPLEEVLAAEYLLEEFRPDLIEMVLDK 752
Query: 482 LVPENSRVTLISRSLE--TDSAEKWYGTAYKVVDYPADLIKNMKSPGLNPALTLPRPNEF 539
L PEN RV ++S+S E TD E+WYGT YK ++IK ++ LN LP NEF
Sbjct: 753 LRPENVRVAIVSKSFEGKTDQTEEWYGTQYKQEAISDEVIKKWQNADLNGKFKLPMKNEF 812
Query: 540 VSTNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLPHTHASIIN 599
+ +NF++ +++ P P L+ +SKLW+K+DD+F+ P+ + F P + ++
Sbjct: 813 IPSNFEILQLEKEAP-SYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLH 871
Query: 600 SMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLIILLTRFLQGV 659
++ LY +L D+L + Y A A L T G+ ++ G+N+K ILL + ++ +
Sbjct: 872 CNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIVEKM 931
Query: 660 NSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKLQVFEKLTF 719
+FE + RFEI+K+ +R L N E P+ Y ++ E +W+ E + + +T
Sbjct: 932 ATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTL 991
Query: 720 EQLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIHN---LQVSNNRLRSY 776
+L FIP + ++ E L+HGNI + AL V +++ + + H L R R
Sbjct: 992 PRLKAFIPQLLSRLHIEALLHGNITKQAALGVMQMVEDTLIEHAHTKPLLPSQLVRYREV 1051
Query: 777 LLPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFAQLIHEPCFDTLRTKE 836
LP F Y+ ++ + N I+ Q D+ S + LF Q+I EPCF+TLRTKE
Sbjct: 1052 QLPDRGWFVYQQ--RNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKE 1109
Query: 837 QLGYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVLRDMPEEDFEKHKE 896
QLGY+VFS +G +R +IQSE YLE R+ F T + + DM EE F+KH +
Sbjct: 1110 QLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQ 1169
Query: 897 ALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMIDFYENYIMSE 956
AL L K K ++ E A+Y I YNF + + +TK+ +I FY+ + E
Sbjct: 1170 ALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIRFYKEMLAVE 1229
Query: 957 --NASKLILHLKSQ------VENKELNENELDTA---KYPTGQLIEDVGAFKSTLFVAPV 1005
K+ +H+ ++ V + +N+++ A P ++IE++ AFK +L + P+
Sbjct: 1230 APRRHKVSVHVLAREMDSCPVVGEFPCQNDVNLAAAPALPQPEVIENMTAFKRSLPLFPL 1289
Query: 1006 RQP 1008
+P
Sbjct: 1290 VKP 1292
>ref|XP_681313.1| hypothetical protein AN8044.2 [Aspergillus nidulans FGSC A4]
gb|EAA59666.1| hypothetical protein AN8044.2 [Aspergillus nidulans FGSC A4]
Length = 1100
Score = 713 bits (1840), Expect = 0.0, Method: Composition-based stats.
Identities = 395/970 (40%), Positives = 574/970 (59%), Gaps = 51/970 (5%)
Query: 66 KPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNLPGLAHFCEHLLF 125
KP LD+RSYR I+LPNKL+ALL+ DP+ DKAAA++DV++G+F DP +L GLAH EH+LF
Sbjct: 15 KPSLDDRSYRVIQLPNKLEALLVHDPETDKAAAAMDVHVGSFSDPADLQGLAHGLEHMLF 74
Query: 126 MGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNH-------------------- 165
MG+EK+P EN Y+ YL+ H GSSNAYTA TNYFFEV+
Sbjct: 75 MGTEKYPVENAYNQYLASHSGSSNAYTAGTETNYFFEVSATGATGESSGQVTPNGTTNGT 134
Query: 166 ---------QHLFGALDRFSGFFSCPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDK 216
L+GALDRF+ FF PLF +++ D+E+ AV+SENKKNLQ+D+WR+ QL+K
Sbjct: 135 SAESKSNGPSPLYGALDRFAQFFISPLFLENTLDREMQAVDSENKKNLQSDLWRLMQLNK 194
Query: 217 SLTNTKHPYHKFSTGNIETLGTLPKENGLNVRDELLKFHKNFYSANLMKLCILGREDLDT 276
SL+N HPY+ FSTGN++TL P++ G+ +R+E +KF++ YSAN MKL +LGRE LD
Sbjct: 195 SLSNPDHPYNHFSTGNLQTLKEEPQKRGVEIRNEFMKFYEKHYSANRMKLVVLGRESLDE 254
Query: 277 LSDWTYDLFKDVANNGREVPLY---AEPIMQPEHLQKIIQVRPVKDLKKLEISFTVPDME 333
L W +LF V+N +++P PI P + K I +PV D + ++I F D E
Sbjct: 255 LEKWVSELFAGVSN--KDLPQNRWDGIPIWLPNDMCKQIFAKPVMDTRSVDIYFPFLDEE 312
Query: 334 EHWESKPPRILSHLIGHEGSGSLLAHLKKLGWANELSAGGHTVSKGNAFFAVDIDLTDNG 393
+ +ES+P R +SHLIGHEG GS+LA++K GWAN LSAG V G AFF V + LT G
Sbjct: 313 KLYESQPSRYISHLIGHEGPGSILAYIKAKGWANGLSAGVMPVCPGAAFFTVSVRLTQEG 372
Query: 394 LTHYRDVIVLIFQYIEMLKNSLPQKWIFNELQDISNATFKFKQAGSPSSTVSSLAKCLEK 453
L Y+ V+ +IF+YI M+K P+ WIF E+++++ FKFKQ S S L+ ++K
Sbjct: 373 LQQYQQVVKVIFEYIAMIKEREPEAWIFEEMKNLAEVEFKFKQKSPASRFTSRLSSVMQK 432
Query: 454 DYIPVSRILAMGLLTKYEPDLLTQYTDALVPENSRVTLISRSL--ETDSAEKWYGTAYKV 511
+P +L+ LL K++P+ + + L +N ++ ++++ + D+ EKWYGT YKV
Sbjct: 433 P-LPREWLLSGSLLRKFDPEAIKKALSYLREDNFKLIVVAQDYPGDWDTKEKWYGTEYKV 491
Query: 512 VDYPADLIKNMKSP-GLNPA-----LTLPRPNEFVSTNFKVDKIDGIKPLDEPVLLLSDD 565
D P D + +++ P L +P NEFV T V+K + +P P L+ DD
Sbjct: 492 EDVPKDFMSGIRAALDTTPETRLKELHMPHKNEFVPTRLSVEKKEVSEPQKTPKLIRHDD 551
Query: 566 VSKLWYKKDDRFWQPRGYIYLSFKLPHTHASIINSMLSTLYTQLANDALKDVQYDAACAD 625
+LW+KKDDRFW P+ ++++ + P A+ N + S LY +L DAL + YDA A
Sbjct: 552 HVRLWFKKDDRFWVPKATVFVTLRNPLVWATPANLVKSKLYCELVRDALVEYSYDAELAG 611
Query: 626 LRISFNKTNQGLAITASGFNEKLIILLTRFLQGVNSFEPKKDRFEILKDKTIRHLKNLLY 685
L + + GL I+ G+N+K+ +LL + + E DRF I+K++ R KN Y
Sbjct: 612 LDYHLSASIFGLDISVGGYNDKMAVLLEKVFTSMRDLEINPDRFRIIKERLTRSYKNAEY 671
Query: 686 EVPYSQMSNYYNAIINERSWSTAEKLQVFEKLTFEQLINFIPTIYEGVYFETLIHGNIKH 745
+ PY Q+ +Y + ER W + + + E + F P I + E L HGNI
Sbjct: 672 QQPYYQVGDYTRYLTAERGWLNEQYAAELDHIEAEDIKCFFPQILRQNHIEVLAHGNIYK 731
Query: 746 EEALEVDSLIKSLIPNNIHNLQVSNNRL-RSYLLPKGKTFRYETALKDSQNVNSCIQHVT 804
E+AL + ++S++ N L S + R+ ++P G + YE LKD NVN CI++
Sbjct: 732 EDALRMTDTVESIL--NSRTLPQSQWYVRRNVIIPPGSDYIYERPLKDPANVNHCIEYYL 789
Query: 805 QL-DVYSEDLSALSGLFAQLIHEPCFDTLRTKEQLGYVVFSSSLNNHGTANIRILIQSEH 863
+ + E L A LFAQ+ EP FD LR+KEQLGYVV+S + + T R++IQSE
Sbjct: 790 FIGSIADEVLRAKLLLFAQMTDEPAFDQLRSKEQLGYVVWSGARYSATTIGYRVIIQSER 849
Query: 864 TTPYLEWRINNFYETFGQVLRDMPEEDFEKHKEALCNSLLQKFKNMAEESARYTAAIYLG 923
T YLE RI++F FG+ L M E++FE HK ++ N L+K KN++ E++R+ + I
Sbjct: 850 TAQYLESRIDSFLSNFGKTLETMTEDEFEGHKRSVINKRLEKLKNLSSETSRFWSHIGSE 909
Query: 924 DYNFTHRQKKAKLVANITKQQMIDFYENYI--MSENASKLILHLKSQ--VENKELNENEL 979
DY+F + A V +TK ++DFY+ I S KL +HLK+Q EL E +
Sbjct: 910 DYDFQQNETDAARVRALTKSDILDFYKQMIDPASPTRGKLSIHLKAQAGAHAVELKEQKA 969
Query: 980 DTAKYPTGQL 989
+ T QL
Sbjct: 970 RLLSFVTKQL 979
>ref|XP_001501085.1| PREDICTED: similar to insulin-degrading enzyme [Equus caballus]
Length = 1212
Score = 710 bits (1833), Expect = 0.0, Method: Composition-based stats.
Identities = 370/965 (38%), Positives = 578/965 (59%), Gaps = 22/965 (2%)
Query: 65 LKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNLPGLAHFCEHLL 124
+K D+R YR ++L N +K LLI DP DK++A+LDV+IG+ DP N+ GL+HFCEH+L
Sbjct: 248 IKSPEDKREYRGLQLANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHML 307
Query: 125 FMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGALDRFSGFFSCPLF 184
F+G++K+P ENEYS +LS+H GSSNA+T+ ++TNY+F+V+H+HL GALDRF+ FF CPLF
Sbjct: 308 FLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLF 367
Query: 185 NKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGTLPKENG 244
++ D+E+NAV+SE++KN+ ND WR++QL+K+ N KHP+ KF TGN TL T P + G
Sbjct: 368 DESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEG 427
Query: 245 LNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGREVPLYAEPIMQ 304
++VR ELLKFH +YS+NLM +C+LGRE LD L+D LF +V N +P + E Q
Sbjct: 428 IDVRQELLKFHSTYYSSNLMAICVLGRESLDDLTDLVVKLFSEVENKNVPLPEFPEHPFQ 487
Query: 305 PEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGSGSLLAHLKKLG 364
EHL+++ ++ P+KD++ L ++F +PD++++++S P L HLIGHEG GSLL+ LK G
Sbjct: 488 EEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKG 547
Query: 365 WANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLPQKWIFNEL 424
W N L G ++G FF +++DLT+ GL H D+I+ +FQYI+ L+ PQ+W+F E
Sbjct: 548 WVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQEC 607
Query: 425 QDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRIL-AMGLLTKYEPDLLTQYTDALV 483
+D++ F+FK P S +A L Y P+ +L A LL ++ PDL+ D L
Sbjct: 608 KDLNAVAFRFKDKERPRGYTSKIAGILH--YYPLEEVLTAEYLLEEFRPDLIEMVLDKLR 665
Query: 484 PENSRVTLISRSLE--TDSAEKWYGTAYKVVDYPADLIKNMKSPGLNPALTLPRPNEFVS 541
PEN RV ++S+S E TD E+WYGT Y+ P ++IK ++ LN LP NEF+
Sbjct: 666 PENVRVAVVSKSFEGKTDCTEEWYGTQYRQEAIPDEVIKKWQNADLNGKFKLPTKNEFIP 725
Query: 542 TNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLPHTHASIINSM 601
TNF++ ++ + P L+ +SKLW+K+DD+F+ P+ + F P + ++
Sbjct: 726 TNFEILSLEK-EATPYPSLIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCN 784
Query: 602 LSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLIILLTRFLQGVNS 661
++ LY +L D+L + Y A A L T G+ ++ G+N+K ILL + ++ + +
Sbjct: 785 MAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMAT 844
Query: 662 FEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKLQVFEKLTFEQ 721
FE + RFEI+K+ +R L N E P+ Y ++ E +W+ E + + +T +
Sbjct: 845 FEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPR 904
Query: 722 LINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIHN---LQVSNNRLRSYLL 778
L FIP + ++ E L+HGNI + AL + +++ + + H L R R L
Sbjct: 905 LKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQL 964
Query: 779 PKGKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFAQLIHEPCFDTLRTKEQL 838
P F Y+ ++ + N I+ Q D+ S + LF Q+I EPCF+TLRTKEQL
Sbjct: 965 PDRGWFVYQQ--RNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQL 1022
Query: 839 GYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVLRDMPEEDFEKHKEAL 898
GY+VFS +G +R +IQSE YLE R+ F T + + DM EE F+KH +AL
Sbjct: 1023 GYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQAL 1082
Query: 899 CNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMIDFYENYIM--SE 956
L K K ++ E A+Y I YNF + + +TK+ +I FY+ + +
Sbjct: 1083 AIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAP 1142
Query: 957 NASKLILHLKSQ------VENKELNENELDTAK---YPTGQLIEDVGAFKSTLFVAPVRQ 1007
K+ +H+ ++ V + +N+++ ++ P ++I+++ FK L + P+ +
Sbjct: 1143 RRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPGLPQPEVIQNMTEFKRGLPLFPLVK 1202
Query: 1008 PMKDF 1012
P +F
Sbjct: 1203 PHINF 1207
>ref|XP_360292.2| hypothetical protein MGG_13149 [Magnaporthe grisea 70-15]
gb|EDK06378.1| hypothetical protein MGG_13149 [Magnaporthe grisea 70-15]
Length = 1086
Score = 710 bits (1832), Expect = 0.0, Method: Composition-based stats.
Identities = 394/945 (41%), Positives = 577/945 (61%), Gaps = 37/945 (3%)
Query: 66 KPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNLPGLAHFCEHLLF 125
+P +D R+YR I L NKL+AL++ DP DKA+A++DVN+GAF D ++PG+AH EHLLF
Sbjct: 16 RPSVDNRTYRVIRLQNKLEALIVHDPDTDKASAAMDVNVGAFSDEDDMPGMAHAVEHLLF 75
Query: 126 MGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEV-------------NHQHLFGAL 172
MG++K+P EN YS YLS + GSSNAYT S +TNY+FEV N L+GA+
Sbjct: 76 MGTKKYPVENAYSQYLSANSGSSNAYTGSTSTNYYFEVAGKPSDDGEASAENPSPLYGAM 135
Query: 173 DRFSGFFSCPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGN 232
DRF+ FF PLF + + D+E+ AV+SENKKNLQ+D+WR +QL KSL+N KHPY FSTGN
Sbjct: 136 DRFAQFFIEPLFLESTLDRELQAVDSENKKNLQSDVWRFHQLVKSLSNPKHPYCHFSTGN 195
Query: 233 IETLGTLPKENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVAN-N 291
E L T P+ G+NVRD+ ++F+ YSANLMKL +LGRE LD L W +LF D+ N N
Sbjct: 196 FEVLKTAPEARGINVRDKFIEFYNKHYSANLMKLVVLGREPLDVLESWVVELFSDIPNKN 255
Query: 292 GREVPLYAEPIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHE 351
+ E PE L I +PV D ++L + F D E H E++P R +SHLIGHE
Sbjct: 256 LPQNRWEDEDPFGPEQLGTQIFTKPVMDNRELNLFFPFMDQENHHETQPSRYISHLIGHE 315
Query: 352 GSGSLLAHLKKLGWANELSAGGHTVSKGN-AFFAVDIDLTDNGLTHYRDVIVLIFQYIEM 410
G GS+++++K +GWAN LSAG + + G+ F + LT+ GL HY++++ FQY+ +
Sbjct: 316 GPGSIMSYVKTMGWANGLSAGAYPICSGSPGIFDCQVRLTEEGLKHYKEIVKAFFQYVSL 375
Query: 411 LKNSLPQKWIFNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILAMGLLTKY 470
L+ + PQ+WIF E Q+++ FKFKQ +P+S +S + + +P +L+ L K+
Sbjct: 376 LRETPPQEWIFKEQQEMTEVEFKFKQK-TPASKFASKTSSVMQSEVPREWLLSYPKLRKF 434
Query: 471 EPDLLTQYTDALVPENSRVTLISRSL--ETDSAEKWYGTAYKVVDYPADLIKNMK-SPGL 527
+P+L+ + D L PEN R+TL SR + D EKWYGT YK P+D ++ +K + +
Sbjct: 435 DPELIKEGIDMLRPENLRLTLSSREYPGDWDQREKWYGTEYKYERIPSDFMEELKQAASV 494
Query: 528 NPA-----LTLPRPNEFVSTNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRG 582
+P L LP N F+ T V+K + +P P L+ +DD+++ WYKKDDRFW P+
Sbjct: 495 SPQQRIRHLHLPHKNMFIPTKLDVEKKEVKEPAIGPRLIRNDDLARTWYKKDDRFWIPKA 554
Query: 583 YIYLSFKLPHTHASIINSMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITAS 642
+ +S K P HAS N + + LYT L DAL++ YDA A L + + GLAI +
Sbjct: 555 ALVVSCKTPLIHASAQNYVRARLYTDLVKDALEEYAYDAEIAGLNYAVSLDAAGLAIQIA 614
Query: 643 GFNEKLIILLTRFLQGVNSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINE 702
G+N+KL +L+ R L V E K++RF I+K++T R +N ++ PY Q+++Y +++E
Sbjct: 615 GYNDKLPVLMERVLLTVRDLEIKEERFNIVKERTGRAYRNWAFQQPYHQITDYSGWLMSE 674
Query: 703 RSWSTAEKLQVFEKLTFEQLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLI-KSLIPN 761
+ + T + + +F + ++ E GN+ E+ L++ ++ K+L P
Sbjct: 675 VDFLIEDIATELPIATIDTVRSFHKEMISQMHMECYALGNLYKEDVLKLTDMVEKTLRPR 734
Query: 762 NIHNLQVSNNRLRSYLLPKGKTFRYETALKDSQNVNSCIQHVTQL----DVYSEDLSALS 817
+ Q R + P G + YET LKD +NVN CI ++ + D+ ++ L A +
Sbjct: 735 ILPKSQWPIT--RQLIFPPGSNYTYETPLKDPKNVNHCIDYLLYVGDIDDMATKPLRAQT 792
Query: 818 GLFAQLIHEPCFDTLRTKEQLGYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYE 877
L Q+ EP FD LRTKEQLGYVVFS + T + R +IQSE YLE RI F
Sbjct: 793 LLLDQMAREPTFDQLRTKEQLGYVVFSGIKSTPTTYSFRFVIQSEKKPSYLESRIEVFLL 852
Query: 878 TFGQVLRDMPEEDFEKHKEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLV 937
FG+ L +M +E+FE HK +L NS L+K KN+ +E AR+ IY G Y+F QK A +
Sbjct: 853 QFGKKLEEMSDEEFESHKRSLINSRLEKVKNLDQEVARHWNQIYNGTYDFERMQKDAANI 912
Query: 938 ANITKQQMIDFYENYI--MSENASKLILHL----KSQVENKELNE 976
+TKQ M++FY +YI S+ +K+++HL KS V +E++E
Sbjct: 913 KLLTKQDMLEFYAHYIDPKSKARAKVVIHLLAQAKSDVSTREISE 957
>ref|NP_001082994.1| insulin-degrading enzyme [Danio rerio]
gb|AAI39608.1| Zgc:162603 protein [Danio rerio]
Length = 978
Score = 707 bits (1825), Expect = 0.0, Method: Composition-based stats.
Identities = 375/967 (38%), Positives = 578/967 (59%), Gaps = 22/967 (2%)
Query: 63 DFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNLPGLAHFCEH 122
D ++ D+R YR +E N LKA+LI DP DK++A+LDV++G+ DP+N+ GLAHFCEH
Sbjct: 12 DIIRSPEDKREYRGLEFTNGLKAILISDPTTDKSSAALDVHMGSLSDPENISGLAHFCEH 71
Query: 123 LLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGALDRFSGFFSCP 182
+LF+G+EK+P ENEYS +LS+H GSSNA+T+ ++TNY+F+V+H+HL GALDRF+ FF CP
Sbjct: 72 MLFLGTEKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLQGALDRFAQFFLCP 131
Query: 183 LFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGTLPKE 242
LF++ D+E+NAV+SE++KNL ND WR++QL+K+ N KHP+ KF TGN TL T P +
Sbjct: 132 LFDESCKDREVNAVDSEHEKNLMNDAWRLFQLEKATGNPKHPFSKFGTGNKLTLETRPSQ 191
Query: 243 NGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGREVPLYAEPI 302
G+++R+ELLKFH +YS+NLM LC+LGRE LD L+ LF +V N VP +
Sbjct: 192 QGIDIREELLKFHSTYYSSNLMGLCVLGRETLDELTSMVVKLFGEVENKNVPVPEFPTHP 251
Query: 303 MQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGSGSLLAHLKK 362
Q EHL++ +V P+KD++ L ++F +PD++++++S P L HLIGHEG GSLL+ LK
Sbjct: 252 FQEEHLRQFYKVVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKS 311
Query: 363 LGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLPQKWIFN 422
GW N L G ++G FF +++DLT+ GL H D+I +FQYI+ L+ PQ+W+F
Sbjct: 312 KGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIIFHMFQYIQKLRTEGPQEWVFQ 371
Query: 423 ELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILAMG-LLTKYEPDLLTQYTDA 481
E +D++ F+FK P S +A L Y P+ ILA LL ++ PDL+ D
Sbjct: 372 ECKDLNTVAFRFKDKERPRGYTSKVAGLLH--YYPLEEILAAEYLLEEFRPDLIEMVLDK 429
Query: 482 LVPENSRVTLISRSLE--TDSAEKWYGTAYKVVDYPADLIKNMKSPGLNPALTLPRPNEF 539
L PEN RV ++S+S E TD E+WYGT YK + IK + LN LP NEF
Sbjct: 430 LRPENVRVAVVSKSFEGQTDRTEEWYGTQYKQEAITDEAIKKWDNADLNGKFKLPMKNEF 489
Query: 540 VSTNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLPHTHASIIN 599
+ TNF++ ++ P P L+ +SK+W+K+DD+F+ P+ + F P + ++
Sbjct: 490 IPTNFEIYPLEKDSP-SAPTLIKDTAMSKVWFKQDDKFFLPKACLNFEFFSPFAYVDPLH 548
Query: 600 SMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLIILLTRFLQGV 659
++ LY +L D+L + Y A A L T G+ ++ G+N+K ILL + ++ +
Sbjct: 549 CNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTVYGMYLSVKGYNDKQHILLKKIIEKM 608
Query: 660 NSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKLQVFEKLTF 719
+FE + RF+I+K+ +R L N E P+ Y ++ E +W+ E + +T
Sbjct: 609 ATFEIDEKRFDIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELRDALDDVTL 668
Query: 720 EQLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIHN---LQVSNNRLRSY 776
+L FIP + ++ E L+HGNI + ALE+ +++ + + H L R R
Sbjct: 669 PRLKAFIPQLLSRLHIEALLHGNITKQSALEMMQMLEDTLIEHAHTKPLLPSQLIRYREV 728
Query: 777 LLPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFAQLIHEPCFDTLRTKE 836
+P G + Y+ ++ + N I+ Q D+ + + L LF Q+I EPCF+TLRTKE
Sbjct: 729 QVPDGGWYVYQQ--RNEVHNNCGIEIYYQTDMQNTHENMLLELFCQIISEPCFNTLRTKE 786
Query: 837 QLGYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVLRDMPEEDFEKHKE 896
QLGY+VFS +G +R +IQSE YLE R+ F +T + + +M +E F+KH +
Sbjct: 787 QLGYIVFSGPRRANGVQGLRFIIQSEKAPHYLESRVEAFLKTMEKSVEEMGDEAFQKHIQ 846
Query: 897 ALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMIDFYENY--IM 954
AL L K K +A E A+Y I YNF + + +TK+ ++ FY + I
Sbjct: 847 ALAIRRLDKPKKLAAECAKYWGEIISQQYNFDRDNIEVAYLKTLTKEHIMQFYRDLLAID 906
Query: 955 SENASKLILH-LKSQVENKEL-----NENELDTAKYPT---GQLIEDVGAFKSTLFVAPV 1005
+ K+ +H L ++++ L +N+++ A P+ L++D+ FK +L + P+
Sbjct: 907 APRRHKVSVHVLSREMDSCPLVGEFPAQNDVNLAPAPSLPQPSLVQDMTEFKRSLPLFPL 966
Query: 1006 RQPMKDF 1012
+P +F
Sbjct: 967 TKPHINF 973
>dbj|BAF62161.1| insulin-degrading enzyme [Danio rerio]
Length = 998
Score = 706 bits (1821), Expect = 0.0, Method: Composition-based stats.
Identities = 375/967 (38%), Positives = 578/967 (59%), Gaps = 22/967 (2%)
Query: 63 DFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNLPGLAHFCEH 122
D ++ D+R YR +E N LKA+LI DP DK++A+LDV++G+ DP+N+ GLAHFCEH
Sbjct: 32 DIIRSPEDKREYRGLESTNGLKAILISDPTTDKSSAALDVHMGSLSDPENISGLAHFCEH 91
Query: 123 LLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGALDRFSGFFSCP 182
+LF+G+EK+P ENEYS +LS+H GSSNA+T+ ++TNY+F+V+H+HL GALDRF+ FF CP
Sbjct: 92 MLFLGTEKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLQGALDRFAQFFLCP 151
Query: 183 LFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGTLPKE 242
LF++ D+E+NAV+SE++KNL ND WR++QL+K+ N KHP+ KF TGN TL T P +
Sbjct: 152 LFDESCKDREVNAVDSEHEKNLMNDAWRLFQLEKATGNPKHPFSKFGTGNKLTLETRPSQ 211
Query: 243 NGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGREVPLYAEPI 302
G+++R+ELLKFH +YS+NLM LC+LGRE LD L+ LF +V N VP +
Sbjct: 212 QGIDIREELLKFHSTYYSSNLMGLCVLGRETLDELTSMVVKLFGEVENKNVPVPEFPTHP 271
Query: 303 MQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGSGSLLAHLKK 362
Q EHL++ +V P+KD++ L ++F +PD++++++S P L HLIGHEG GSLL+ LK
Sbjct: 272 FQEEHLRQFYKVVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKS 331
Query: 363 LGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLPQKWIFN 422
GW N L G ++G FF +++DLT+ GL H D+I +FQYI+ L+ PQ+W+F
Sbjct: 332 KGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIIFHMFQYIQKLRTEGPQEWVFQ 391
Query: 423 ELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILAMG-LLTKYEPDLLTQYTDA 481
E +D++ F+FK P S +A L Y P+ ILA LL ++ PDL+ D
Sbjct: 392 ECKDLNTVAFRFKDKERPRGYTSKVAGLLH--YYPLEEILAAEYLLEEFRPDLIEMVLDK 449
Query: 482 LVPENSRVTLISRSLE--TDSAEKWYGTAYKVVDYPADLIKNMKSPGLNPALTLPRPNEF 539
L PEN RV ++S+S E TD E+WYGT YK + IK + LN LP NEF
Sbjct: 450 LRPENVRVAVVSKSFEGQTDRTEEWYGTQYKQEAITDEAIKKWDNADLNGKFKLPMKNEF 509
Query: 540 VSTNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLPHTHASIIN 599
+ TNF++ ++ P P L+ +SK+W+K+DD+F+ P+ + F P + ++
Sbjct: 510 IPTNFEIYPLEKDSP-SAPTLIKDTAMSKVWFKQDDKFFLPKACLNFEFFSPFAYVDPLH 568
Query: 600 SMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLIILLTRFLQGV 659
++ LY +L D+L + Y A A L T G+ ++ G+N+K ILL + ++ +
Sbjct: 569 CNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTVYGMYLSVKGYNDKQHILLKKIIEKM 628
Query: 660 NSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKLQVFEKLTF 719
+FE + RF+I+K+ +R L N E P+ Y ++ E +W+ E + +T
Sbjct: 629 ATFEIDEKRFDIIKEAYMRPLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELRDALDDVTL 688
Query: 720 EQLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIHN---LQVSNNRLRSY 776
+L FIP + ++ E L+HGNI + ALE+ +++ + + H L R R
Sbjct: 689 PRLKAFIPQLLSRLHIEALLHGNITKQSALEMMQMLEDTLIEHAHTKPLLPSQLIRYREV 748
Query: 777 LLPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFAQLIHEPCFDTLRTKE 836
+P G + Y+ ++ + N I+ Q D+ + + L LF Q+I EPCF+TLRTKE
Sbjct: 749 QVPDGGWYVYQQ--RNEVHNNCGIEIYYQTDMQNTHENMLLELFCQIISEPCFNTLRTKE 806
Query: 837 QLGYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVLRDMPEEDFEKHKE 896
QLGY+VFS +G +R +IQSE YLE R+ F +T + + +M +E F+KH +
Sbjct: 807 QLGYIVFSGPRRANGVQGLRFIIQSEKAPHYLESRVEAFLKTMEKSVEEMGDEAFQKHIQ 866
Query: 897 ALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMIDFYENY--IM 954
AL L K K +A E A+Y I YNF + + +TK+ ++ FY + I
Sbjct: 867 ALAIRRLDKPKKLAAECAKYWGEIISQQYNFDRDNIEVAYLKTLTKEHIMQFYRDLLAID 926
Query: 955 SENASKLILH-LKSQVENKEL-----NENELDTAKYPT---GQLIEDVGAFKSTLFVAPV 1005
+ K+ +H L ++++ L +N+++ A P+ L++D+ FK +L + P+
Sbjct: 927 APRRHKVSVHVLSREMDSCPLVGEFPAQNDVNLAPAPSLPQPSLVQDMTEFKRSLPLFPL 986
Query: 1006 RQPMKDF 1012
+P +F
Sbjct: 987 TKPHINF 993
>ref|NP_112419.2| insulin degrading enzyme [Mus musculus]
gb|AAH41675.1| Insulin degrading enzyme [Mus musculus]
Length = 1019
Score = 705 bits (1820), Expect = 0.0, Method: Composition-based stats.
Identities = 373/965 (38%), Positives = 577/965 (59%), Gaps = 22/965 (2%)
Query: 65 LKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNLPGLAHFCEHLL 124
+K D+R YR +EL N +K LLI DP DK++A+LDV+IG+ DP N+PGL+HFCEH+L
Sbjct: 55 VKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIPGLSHFCEHML 114
Query: 125 FMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGALDRFSGFFSCPLF 184
F+G++K+P ENEYS +LS+H GSSNA+T+ ++TNY+F+V+H+HL GALDRF+ FF CPLF
Sbjct: 115 FLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLF 174
Query: 185 NKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGTLPKENG 244
+ D+E+NAV+SE++KN+ ND WR++QL+K+ N KHP+ KF TGN TL T P + G
Sbjct: 175 DASCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEG 234
Query: 245 LNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGREVPLYAEPIMQ 304
++VR+ELLKFH +YS+NLM +C+LGRE LD L++ LF +V N +P + E Q
Sbjct: 235 IDVREELLKFHSTYYSSNLMAICVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQ 294
Query: 305 PEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGSGSLLAHLKKLG 364
EHL+++ ++ P+KD++ L ++F +PD++++++S P L HLIGHEG GSLL+ LK G
Sbjct: 295 EEHLRQLYKIVPIKDIRNLYVTFPIPDLQQYYKSNPGHYLGHLIGHEGPGSLLSELKSKG 354
Query: 365 WANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLPQKWIFNEL 424
W N L G ++G FF +++DLT+ GL H D+I+ +FQYI+ L+ PQ+W+F E
Sbjct: 355 WVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQEC 414
Query: 425 QDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRIL-AMGLLTKYEPDLLTQYTDALV 483
+D++ F+FK P S +A L Y P++ +L A LL ++ PDL+ D L
Sbjct: 415 KDLNAVAFRFKDKERPRGYTSKIAGKLH--YYPLNGVLTAEYLLEEFRPDLIDMVLDKLR 472
Query: 484 PENSRVTLISRSLE--TDSAEKWYGTAYKVVDYPADLIKNMKSPGLNPALTLPRPNEFVS 541
PEN RV ++S+S E TD E+WYGT YK P D+I+ ++ LN LP NEF+
Sbjct: 473 PENVRVAIVSKSFEGKTDRTEQWYGTQYKQEAIPEDIIQKWQNADLNGKFKLPTKNEFIP 532
Query: 542 TNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLPHTHASIINSM 601
TNF++ ++ P L+ +SKLW+K+DD+F+ P+ + F P + ++
Sbjct: 533 TNFEILSLEK-DATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCN 591
Query: 602 LSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLIILLTRFLQGVNS 661
++ LY +L D+L + Y A A L T G+ ++ G+N+K ILL + + + +
Sbjct: 592 MAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKITEKMAT 651
Query: 662 FEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKLQVFEKLTFEQ 721
FE K RFEI+K+ +R L N E P+ Y ++ E +W+ E + + +T +
Sbjct: 652 FEIDKKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPR 711
Query: 722 LINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIHN---LQVSNNRLRSYLL 778
L FIP + ++ E L+HGNI + AL V +++ + + H L R R L
Sbjct: 712 LKAFIPQLLSRLHIEALLHGNITKQAALGVMQMVEDTLIEHAHTKPLLPSQLVRYREVQL 771
Query: 779 PKGKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFAQLIHEPCFDTLRTKEQL 838
P F Y+ ++ + N I+ Q D+ S + LF Q+I EPCF+TLRTKEQL
Sbjct: 772 PDRGWFVYQQ--RNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQL 829
Query: 839 GYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVLRDMPEEDFEKHKEAL 898
GY+VFS +G +R +IQSE YLE R+ F T + + DM EE F+KH +AL
Sbjct: 830 GYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKAIEDMTEEAFQKHIQAL 889
Query: 899 CNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMIDFYENYIM--SE 956
L K K ++ E A+Y I YN+ + + +TK +I FY+ + +
Sbjct: 890 AIRRLDKPKKLSAECAKYWGEIISQQYNYDRDNIEVAYLKTLTKDDIIRFYQEMLAVDAP 949
Query: 957 NASKLILHLKSQ------VENKELNENELDTAK---YPTGQLIEDVGAFKSTLFVAPVRQ 1007
K+ +H+ ++ V + ++N+++ ++ P ++I ++ FK L + P+ +
Sbjct: 950 RRHKVSVHVLAREMDSCPVVGEFPSQNDINLSEAPPLPQPEVIHNMTEFKRGLPLFPLVK 1009
Query: 1008 PMKDF 1012
P +F
Sbjct: 1010 PHINF 1014
>gb|EDL41785.1| insulin degrading enzyme [Mus musculus]
Length = 978
Score = 704 bits (1818), Expect = 0.0, Method: Composition-based stats.
Identities = 373/965 (38%), Positives = 577/965 (59%), Gaps = 22/965 (2%)
Query: 65 LKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNLPGLAHFCEHLL 124
+K D+R YR +EL N +K LLI DP DK++A+LDV+IG+ DP N+PGL+HFCEH+L
Sbjct: 14 VKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIPGLSHFCEHML 73
Query: 125 FMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGALDRFSGFFSCPLF 184
F+G++K+P ENEYS +LS+H GSSNA+T+ ++TNY+F+V+H+HL GALDRF+ FF CPLF
Sbjct: 74 FLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLF 133
Query: 185 NKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGTLPKENG 244
+ D+E+NAV+SE++KN+ ND WR++QL+K+ N KHP+ KF TGN TL T P + G
Sbjct: 134 DASCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEG 193
Query: 245 LNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGREVPLYAEPIMQ 304
++VR+ELLKFH +YS+NLM +C+LGRE LD L++ LF +V N +P + E Q
Sbjct: 194 IDVREELLKFHSTYYSSNLMAICVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQ 253
Query: 305 PEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGSGSLLAHLKKLG 364
EHL+++ ++ P+KD++ L ++F +PD++++++S P L HLIGHEG GSLL+ LK G
Sbjct: 254 EEHLRQLYKIVPIKDIRNLYVTFPIPDLQQYYKSNPGHYLGHLIGHEGPGSLLSELKSKG 313
Query: 365 WANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLPQKWIFNEL 424
W N L G ++G FF +++DLT+ GL H D+I+ +FQYI+ L+ PQ+W+F E
Sbjct: 314 WVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQEC 373
Query: 425 QDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRIL-AMGLLTKYEPDLLTQYTDALV 483
+D++ F+FK P S +A L Y P++ +L A LL ++ PDL+ D L
Sbjct: 374 KDLNAVAFRFKDKERPRGYTSKIAGKLH--YYPLNGVLTAEYLLEEFRPDLIDMVLDKLR 431
Query: 484 PENSRVTLISRSLE--TDSAEKWYGTAYKVVDYPADLIKNMKSPGLNPALTLPRPNEFVS 541
PEN RV ++S+S E TD E+WYGT YK P D+I+ ++ LN LP NEF+
Sbjct: 432 PENVRVAIVSKSFEGKTDRTEQWYGTQYKQEAIPEDIIQKWQNADLNGKFKLPTKNEFIP 491
Query: 542 TNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLPHTHASIINSM 601
TNF++ ++ P L+ +SKLW+K+DD+F+ P+ + F P + ++
Sbjct: 492 TNFEILSLEK-DATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCN 550
Query: 602 LSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLIILLTRFLQGVNS 661
++ LY +L D+L + Y A A L T G+ ++ G+N+K ILL + + + +
Sbjct: 551 MAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKITEKMAT 610
Query: 662 FEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKLQVFEKLTFEQ 721
FE K RFEI+K+ +R L N E P+ Y ++ E +W+ E + + +T +
Sbjct: 611 FEIDKKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPR 670
Query: 722 LINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIHN---LQVSNNRLRSYLL 778
L FIP + ++ E L+HGNI + AL V +++ + + H L R R L
Sbjct: 671 LKAFIPQLLSRLHIEALLHGNITKQAALGVMQMVEDTLIEHAHTKPLLPSQLVRYREVQL 730
Query: 779 PKGKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFAQLIHEPCFDTLRTKEQL 838
P F Y+ ++ + N I+ Q D+ S + LF Q+I EPCF+TLRTKEQL
Sbjct: 731 PDRGWFVYQQ--RNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQL 788
Query: 839 GYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVLRDMPEEDFEKHKEAL 898
GY+VFS +G +R +IQSE YLE R+ F T + + DM EE F+KH +AL
Sbjct: 789 GYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKAIEDMTEEAFQKHIQAL 848
Query: 899 CNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMIDFYENYIM--SE 956
L K K ++ E A+Y I YN+ + + +TK +I FY+ + +
Sbjct: 849 AIRRLDKPKKLSAECAKYWGEIISQQYNYDRDNIEVAYLKTLTKDDIIRFYQEMLAVDAP 908
Query: 957 NASKLILHLKSQ------VENKELNENELDTAK---YPTGQLIEDVGAFKSTLFVAPVRQ 1007
K+ +H+ ++ V + ++N+++ ++ P ++I ++ FK L + P+ +
Sbjct: 909 RRHKVSVHVLAREMDSCPVVGEFPSQNDINLSEAPPLPQPEVIHNMTEFKRGLPLFPLVK 968
Query: 1008 PMKDF 1012
P +F
Sbjct: 969 PHINF 973
>ref|NP_037291.1| insulin degrading enzyme [Rattus norvegicus]
sp|P35559|IDE_RAT Insulin-degrading enzyme (Insulysin) (Insulinase) (Insulin protease)
emb|CAA47689.1| insulin-degrading enzyme [Rattus norvegicus]
gb|EDM13196.1| insulin degrading enzyme [Rattus norvegicus]
Length = 1019
Score = 703 bits (1815), Expect = 0.0, Method: Composition-based stats.
Identities = 372/965 (38%), Positives = 577/965 (59%), Gaps = 22/965 (2%)
Query: 65 LKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNLPGLAHFCEHLL 124
+K D+R YR +EL N +K LLI DP DK++A+LDV+IG+ DP N+PGL+HFCEH+L
Sbjct: 55 VKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIPGLSHFCEHML 114
Query: 125 FMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGALDRFSGFFSCPLF 184
F+G++K+P ENEYS +LS+H GSSNA+T+ ++TNY+F+V+H+HL GALDRF+ FF CPLF
Sbjct: 115 FLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLF 174
Query: 185 NKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGTLPKENG 244
+ D+E+NAV+SE++KN+ ND WR++QL+K+ N KHP+ KF TGN TL T P + G
Sbjct: 175 DASCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEG 234
Query: 245 LNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGREVPLYAEPIMQ 304
++VR+ELLKFH +YS+NLM +C+LGRE LD L++ LF +V N +P + E Q
Sbjct: 235 IDVREELLKFHSTYYSSNLMAICVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQ 294
Query: 305 PEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGSGSLLAHLKKLG 364
EHL+++ ++ P+KD++ L ++F +PD++++++S P L HLIGHEG GSLL+ LK G
Sbjct: 295 EEHLKQLYKIVPIKDIRNLYVTFPIPDLQQYYKSNPGHYLGHLIGHEGPGSLLSELKSKG 354
Query: 365 WANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLPQKWIFNEL 424
W N L G ++G FF +++DLT+ GL H D+I+ +FQYI+ L+ PQ+W+F E
Sbjct: 355 WVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQEC 414
Query: 425 QDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRIL-AMGLLTKYEPDLLTQYTDALV 483
+D++ F+FK P S +A L Y P++ +L A LL ++ PDL+ D L
Sbjct: 415 KDLNAVAFRFKDKERPRGYTSKIAGKLH--YYPLNGVLTAEYLLEEFRPDLIDMVLDKLR 472
Query: 484 PENSRVTLISRSLE--TDSAEKWYGTAYKVVDYPADLIKNMKSPGLNPALTLPRPNEFVS 541
PEN RV ++S+S E TD E+WYGT YK P D+I+ ++ LN LP NEF+
Sbjct: 473 PENVRVAIVSKSFEGKTDRTEQWYGTQYKQEAIPEDVIQKWQNADLNGKFKLPTKNEFIP 532
Query: 542 TNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLPHTHASIINSM 601
TNF++ ++ P L+ +SKLW+K+DD+F+ P+ + F P + ++
Sbjct: 533 TNFEILALEK-DATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCN 591
Query: 602 LSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLIILLTRFLQGVNS 661
++ LY +L D+L + Y A A L T G+ ++ G+N+K ILL + + + +
Sbjct: 592 MAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKITEKMAT 651
Query: 662 FEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKLQVFEKLTFEQ 721
FE K RFEI+K+ +R L N E P+ Y ++ E +W+ E + + +T +
Sbjct: 652 FEIDKKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPR 711
Query: 722 LINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIHN---LQVSNNRLRSYLL 778
L FIP + ++ E L+HGNI + AL V +++ + + H L R R L
Sbjct: 712 LKAFIPQLLSRLHIEALLHGNITKQAALGVMQMVEDTLIEHAHTKPLLPSQLVRYREVQL 771
Query: 779 PKGKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFAQLIHEPCFDTLRTKEQL 838
P F Y+ ++ + N I+ Q D+ S + LF Q+I EPCF+TLRTKEQL
Sbjct: 772 PDRGWFVYQR--RNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQL 829
Query: 839 GYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVLRDMPEEDFEKHKEAL 898
GY+VFS +G +R +IQSE YLE R+ F T + + DM EE F+KH +AL
Sbjct: 830 GYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKAIEDMTEEAFQKHIQAL 889
Query: 899 CNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMIDFYENYIM--SE 956
L K K ++ E A+Y I YN+ + + ++K +I FY+ + +
Sbjct: 890 AIRRLDKPKKLSAECAKYWGEIISQQYNYDRDNIEVAYLKTLSKDDIIKFYKEMLAVDAP 949
Query: 957 NASKLILHLKSQ------VENKELNENELDTAK---YPTGQLIEDVGAFKSTLFVAPVRQ 1007
K+ +H+ ++ V + ++N+++ ++ P ++I ++ FK L + P+ +
Sbjct: 950 RRHKVSVHVLAREMDSCPVVGEFPSQNDINLSEAPPLPQPEVIHNMTEFKRGLPLFPLVK 1009
Query: 1008 PMKDF 1012
P +F
Sbjct: 1010 PHINF 1014
>ref|NP_004960.2| insulysin [Homo sapiens]
emb|CAI13670.1| insulin-degrading enzyme [Homo sapiens]
gb|AAH96337.1| Insulin-degrading enzyme [Homo sapiens]
gb|AAH96339.1| Insulin-degrading enzyme [Homo sapiens]
gb|AAH96336.1| Insulin-degrading enzyme [Homo sapiens]
gb|EAW50090.1| insulin-degrading enzyme, isoform CRA_a [Homo sapiens]
gb|EAW50091.1| insulin-degrading enzyme, isoform CRA_a [Homo sapiens]
Length = 1019
Score = 702 bits (1811), Expect = 0.0, Method: Composition-based stats.
Identities = 373/965 (38%), Positives = 577/965 (59%), Gaps = 32/965 (3%)
Query: 70 DERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNLPGLAHFCEHLLFMGSE 129
D+R YR +EL N +K LLI DP DK++A+LDV+IG+ DP N+ GL+HFCEH+LF+G++
Sbjct: 60 DKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTK 119
Query: 130 KFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGALDRFSGFFSCPLFNKDST 189
K+P ENEYS +LS+H GSSNA+T+ ++TNY+F+V+H+HL GALDRF+ FF CPLF++
Sbjct: 120 KYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCK 179
Query: 190 DKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGTLPKENGLNVRD 249
D+E+NAV+SE++KN+ ND WR++QL+K+ N KHP+ KF TGN TL T P + G++VR
Sbjct: 180 DREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQ 239
Query: 250 ELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGREVPLYAEPIMQPEHLQ 309
ELLKFH +YS+NLM +C+LGRE LD L++ LF +V N +P + E Q EHL+
Sbjct: 240 ELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLK 299
Query: 310 KIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGSGSLLAHLKKLGWANEL 369
++ ++ P+KD++ L ++F +PD++++++S P L HLIGHEG GSLL+ LK GW N L
Sbjct: 300 QLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTL 359
Query: 370 SAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLPQKWIFNELQDISN 429
G ++G FF +++DLT+ GL H D+I+ +FQYI+ L+ PQ+W+F E +D++
Sbjct: 360 VGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNA 419
Query: 430 ATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRIL-AMGLLTKYEPDLLTQYTDALVPENSR 488
F+FK P S +A L Y P+ +L A LL ++ PDL+ D L PEN R
Sbjct: 420 VAFRFKDKERPRGYTSKIAGILH--YYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVR 477
Query: 489 VTLISRSLE--TDSAEKWYGTAYKVVDYPADLIKNMKSPGLNPALTLPRPNEFVSTNFKV 546
V ++S+S E TD E+WYGT YK P ++IK ++ LN LP NEF+ TNF+
Sbjct: 478 VAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFE- 536
Query: 547 DKIDGIKPLDE-----PVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLPHTHASIINSM 601
I PL++ P L+ +SKLW+K+DD+F+ P+ + F P + ++
Sbjct: 537 -----ILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCN 591
Query: 602 LSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLIILLTRFLQGVNS 661
++ LY +L D+L + Y A A L T G+ ++ G+N+K ILL + ++ + +
Sbjct: 592 MAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMAT 651
Query: 662 FEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKLQVFEKLTFEQ 721
FE + RFEI+K+ +R L N E P+ Y ++ E +W+ E + + +T +
Sbjct: 652 FEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPR 711
Query: 722 LINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIHN---LQVSNNRLRSYLL 778
L FIP + ++ E L+HGNI + AL + +++ + + H L R R L
Sbjct: 712 LKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQL 771
Query: 779 PKGKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFAQLIHEPCFDTLRTKEQL 838
P F Y+ ++ + N I+ Q D+ S + LF Q+I EPCF+TLRTKEQL
Sbjct: 772 PDRGWFVYQQ--RNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQL 829
Query: 839 GYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVLRDMPEEDFEKHKEAL 898
GY+VFS +G +R +IQSE YLE R+ F T + + DM EE F+KH +AL
Sbjct: 830 GYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQAL 889
Query: 899 CNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMIDFYENYIM--SE 956
L K K ++ E A+Y I YNF + + +TK+ +I FY+ + +
Sbjct: 890 AIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAP 949
Query: 957 NASKLILHLKSQ------VENKELNENELDTAK---YPTGQLIEDVGAFKSTLFVAPVRQ 1007
K+ +H+ ++ V + +N+++ ++ P ++I+++ FK L + P+ +
Sbjct: 950 RRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVK 1009
Query: 1008 PMKDF 1012
P +F
Sbjct: 1010 PHINF 1014
>ref|XP_507922.2| PREDICTED: insulysin isoform 4 [Pan troglodytes]
Length = 1019
Score = 702 bits (1811), Expect = 0.0, Method: Composition-based stats.
Identities = 373/965 (38%), Positives = 577/965 (59%), Gaps = 32/965 (3%)
Query: 70 DERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNLPGLAHFCEHLLFMGSE 129
D+R YR +EL N +K LLI DP DK++A+LDV+IG+ DP N+ GL+HFCEH+LF+G++
Sbjct: 60 DKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTK 119
Query: 130 KFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGALDRFSGFFSCPLFNKDST 189
K+P ENEYS +LS+H GSSNA+T+ ++TNY+F+V+H+HL GALDRF+ FF CPLF++
Sbjct: 120 KYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCK 179
Query: 190 DKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGTLPKENGLNVRD 249
D+E+NAV+SE++KN+ ND WR++QL+K+ N KHP+ KF TGN TL T P + G++VR
Sbjct: 180 DREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQ 239
Query: 250 ELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGREVPLYAEPIMQPEHLQ 309
ELLKFH +YS+NLM +C+LGRE LD L++ LF +V N +P + E Q EHL+
Sbjct: 240 ELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLK 299
Query: 310 KIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGSGSLLAHLKKLGWANEL 369
++ ++ P+KD++ L ++F +PD++++++S P L HLIGHEG GSLL+ LK GW N L
Sbjct: 300 QLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTL 359
Query: 370 SAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLPQKWIFNELQDISN 429
G ++G FF +++DLT+ GL H D+I+ +FQYI+ L+ PQ+W+F E +D++
Sbjct: 360 VGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNA 419
Query: 430 ATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRIL-AMGLLTKYEPDLLTQYTDALVPENSR 488
F+FK P S +A L Y P+ +L A LL ++ PDL+ D L PEN R
Sbjct: 420 VAFRFKDKERPRGYTSKIAGILH--YYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVR 477
Query: 489 VTLISRSLE--TDSAEKWYGTAYKVVDYPADLIKNMKSPGLNPALTLPRPNEFVSTNFKV 546
V ++S+S E TD E+WYGT YK P ++IK ++ LN LP NEF+ TNF+
Sbjct: 478 VAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFE- 536
Query: 547 DKIDGIKPLDE-----PVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLPHTHASIINSM 601
I PL++ P L+ +SKLW+K+DD+F+ P+ + F P + ++
Sbjct: 537 -----ILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCN 591
Query: 602 LSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLIILLTRFLQGVNS 661
++ LY +L D+L + Y A A L T G+ ++ G+N+K ILL + ++ + +
Sbjct: 592 MAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMAT 651
Query: 662 FEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKLQVFEKLTFEQ 721
FE + RFEI+K+ +R L N E P+ Y ++ E +W+ E + + +T +
Sbjct: 652 FEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPR 711
Query: 722 LINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIHN---LQVSNNRLRSYLL 778
L FIP + ++ E L+HGNI + AL + +++ + + H L R R L
Sbjct: 712 LKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQL 771
Query: 779 PKGKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFAQLIHEPCFDTLRTKEQL 838
P F Y+ ++ + N I+ Q D+ S + LF Q+I EPCF+TLRTKEQL
Sbjct: 772 PDRGWFVYQQ--RNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQL 829
Query: 839 GYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVLRDMPEEDFEKHKEAL 898
GY+VFS +G +R +IQSE YLE R+ F T + + DM EE F+KH +AL
Sbjct: 830 GYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQAL 889
Query: 899 CNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMIDFYENYIM--SE 956
L K K ++ E A+Y I YNF + + +TK+ +I FY+ + +
Sbjct: 890 AIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAP 949
Query: 957 NASKLILHLKSQ------VENKELNENELDTAK---YPTGQLIEDVGAFKSTLFVAPVRQ 1007
K+ +H+ ++ V + +N+++ ++ P ++I+++ FK L + P+ +
Sbjct: 950 RRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVK 1009
Query: 1008 PMKDF 1012
P +F
Sbjct: 1010 PHINF 1014
>ref|NP_001069317.1| insulin-degrading enzyme [Bos taurus]
sp|Q24K02|IDE_BOVIN Insulin-degrading enzyme (Insulysin) (Insulinase) (Insulin protease)
gb|AAI14106.1| Similar to Insulin-degrading enzyme (Insulysin) (Insulinase) (Insulin
protease) [Bos taurus]
Length = 1019
Score = 701 bits (1810), Expect = 0.0, Method: Composition-based stats.
Identities = 370/965 (38%), Positives = 578/965 (59%), Gaps = 22/965 (2%)
Query: 65 LKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNLPGLAHFCEHLL 124
+K D+R YR +EL N +K LL+ DP DK++A+LDV+IG+ DP N+ GL+HFCEH+L
Sbjct: 55 IKSHEDKREYRGLELANGIKVLLVSDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHML 114
Query: 125 FMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGALDRFSGFFSCPLF 184
F+G++K+P ENEYS +LS+H GSSNA+T+ ++TNY+F+V+H+HL GALDRF+ FF CPLF
Sbjct: 115 FLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLF 174
Query: 185 NKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGTLPKENG 244
++ D+E+NAV+SE++KN+ ND WR++QL+K+ N KHP+ KF TGN TL T P + G
Sbjct: 175 DESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEG 234
Query: 245 LNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGREVPLYAEPIMQ 304
++VR ELLKFH +YS+NLM +C+LGRE LD L++ LF +V N +P + E Q
Sbjct: 235 IDVRQELLKFHSTYYSSNLMAICVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQ 294
Query: 305 PEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGSGSLLAHLKKLG 364
EHL+++ ++ P+KD++ L ++F +PD++++++S P L HLIGHEG GSLL+ LK G
Sbjct: 295 EEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKG 354
Query: 365 WANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLPQKWIFNEL 424
W N L G ++G FF +++DLT+ GL H D+I+ +FQYI+ L+ PQ+W+F E
Sbjct: 355 WVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQEC 414
Query: 425 QDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRIL-AMGLLTKYEPDLLTQYTDALV 483
+D++ F+FK P S +A L Y P+ +L A LL ++ PDL+ D L
Sbjct: 415 KDLNAVAFRFKDKERPRGYTSKIAGILH--YYPLEEVLTAEYLLEEFRPDLIEMVLDKLR 472
Query: 484 PENSRVTLISRSLE--TDSAEKWYGTAYKVVDYPADLIKNMKSPGLNPALTLPRPNEFVS 541
PEN RV ++S+S E TD E+WYGT YK P ++IK ++ LN LP NEF+
Sbjct: 473 PENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPMKNEFIP 532
Query: 542 TNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLPHTHASIINSM 601
TNF++ ++ + P L+ +SKLW+K+DD+F+ P+ + F P + ++
Sbjct: 533 TNFEILSLEK-EATPYPSLIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCN 591
Query: 602 LSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLIILLTRFLQGVNS 661
++ LY +L D+L + Y A A L T G+ ++ G+N+K ILL + ++ + +
Sbjct: 592 MAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMAT 651
Query: 662 FEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKLQVFEKLTFEQ 721
FE + RFEI+K+ +R L N E P+ Y ++ E +W+ E + + +T +
Sbjct: 652 FEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPR 711
Query: 722 LINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIHN---LQVSNNRLRSYLL 778
L FIP + ++ E L+HGNI + AL + +++ + + H L R R L
Sbjct: 712 LKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQL 771
Query: 779 PKGKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFAQLIHEPCFDTLRTKEQL 838
P F Y+ ++ + N I+ Q D+ S + LF Q+I EPCF+TLRTKEQL
Sbjct: 772 PDRGWFVYQQ--RNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQL 829
Query: 839 GYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVLRDMPEEDFEKHKEAL 898
GY+VFS +G +R +IQSE YLE R+ F T + + DM EE F+KH +AL
Sbjct: 830 GYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQAL 889
Query: 899 CNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMIDFYENYIM--SE 956
L K K ++ E A+Y I YNF + + +TK+ +I FY+ + +
Sbjct: 890 AIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNIEVAYLKTLTKEDIIKFYKEMLAVDAP 949
Query: 957 NASKLILHLKSQ------VENKELNENELDTAK---YPTGQLIEDVGAFKSTLFVAPVRQ 1007
K+ +H+ ++ V + +N+++ ++ P ++I+++ FK L + P+ +
Sbjct: 950 RRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVK 1009
Query: 1008 PMKDF 1012
P +F
Sbjct: 1010 PHINF 1014
>ref|XP_001146520.1| PREDICTED: insulysin isoform 2 [Pan troglodytes]
gb|EAW50093.1| insulin-degrading enzyme, isoform CRA_c [Homo sapiens]
Length = 978
Score = 701 bits (1810), Expect = 0.0, Method: Composition-based stats.
Identities = 373/965 (38%), Positives = 577/965 (59%), Gaps = 32/965 (3%)
Query: 70 DERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNLPGLAHFCEHLLFMGSE 129
D+R YR +EL N +K LLI DP DK++A+LDV+IG+ DP N+ GL+HFCEH+LF+G++
Sbjct: 19 DKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTK 78
Query: 130 KFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGALDRFSGFFSCPLFNKDST 189
K+P ENEYS +LS+H GSSNA+T+ ++TNY+F+V+H+HL GALDRF+ FF CPLF++
Sbjct: 79 KYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCK 138
Query: 190 DKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGTLPKENGLNVRD 249
D+E+NAV+SE++KN+ ND WR++QL+K+ N KHP+ KF TGN TL T P + G++VR
Sbjct: 139 DREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQ 198
Query: 250 ELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGREVPLYAEPIMQPEHLQ 309
ELLKFH +YS+NLM +C+LGRE LD L++ LF +V N +P + E Q EHL+
Sbjct: 199 ELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLK 258
Query: 310 KIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGSGSLLAHLKKLGWANEL 369
++ ++ P+KD++ L ++F +PD++++++S P L HLIGHEG GSLL+ LK GW N L
Sbjct: 259 QLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTL 318
Query: 370 SAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLPQKWIFNELQDISN 429
G ++G FF +++DLT+ GL H D+I+ +FQYI+ L+ PQ+W+F E +D++
Sbjct: 319 VGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNA 378
Query: 430 ATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRIL-AMGLLTKYEPDLLTQYTDALVPENSR 488
F+FK P S +A L Y P+ +L A LL ++ PDL+ D L PEN R
Sbjct: 379 VAFRFKDKERPRGYTSKIAGILH--YYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVR 436
Query: 489 VTLISRSLE--TDSAEKWYGTAYKVVDYPADLIKNMKSPGLNPALTLPRPNEFVSTNFKV 546
V ++S+S E TD E+WYGT YK P ++IK ++ LN LP NEF+ TNF+
Sbjct: 437 VAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFE- 495
Query: 547 DKIDGIKPLDE-----PVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLPHTHASIINSM 601
I PL++ P L+ +SKLW+K+DD+F+ P+ + F P + ++
Sbjct: 496 -----ILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCN 550
Query: 602 LSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLIILLTRFLQGVNS 661
++ LY +L D+L + Y A A L T G+ ++ G+N+K ILL + ++ + +
Sbjct: 551 MAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMAT 610
Query: 662 FEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKLQVFEKLTFEQ 721
FE + RFEI+K+ +R L N E P+ Y ++ E +W+ E + + +T +
Sbjct: 611 FEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPR 670
Query: 722 LINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIHN---LQVSNNRLRSYLL 778
L FIP + ++ E L+HGNI + AL + +++ + + H L R R L
Sbjct: 671 LKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQL 730
Query: 779 PKGKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFAQLIHEPCFDTLRTKEQL 838
P F Y+ ++ + N I+ Q D+ S + LF Q+I EPCF+TLRTKEQL
Sbjct: 731 PDRGWFVYQQ--RNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQL 788
Query: 839 GYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVLRDMPEEDFEKHKEAL 898
GY+VFS +G +R +IQSE YLE R+ F T + + DM EE F+KH +AL
Sbjct: 789 GYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQAL 848
Query: 899 CNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMIDFYENYIM--SE 956
L K K ++ E A+Y I YNF + + +TK+ +I FY+ + +
Sbjct: 849 AIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAP 908
Query: 957 NASKLILHLKSQ------VENKELNENELDTAK---YPTGQLIEDVGAFKSTLFVAPVRQ 1007
K+ +H+ ++ V + +N+++ ++ P ++I+++ FK L + P+ +
Sbjct: 909 RRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVK 968
Query: 1008 PMKDF 1012
P +F
Sbjct: 969 PHINF 973
>pdb|2G47|A Chain A, Crystal Structure Of Human Insulin-Degrading Enzyme In
Complex With Amyloid-Beta (1-40)
pdb|2G47|B Chain B, Crystal Structure Of Human Insulin-Degrading Enzyme In
Complex With Amyloid-Beta (1-40)
pdb|2G48|A Chain A, Crystal Structure Of Human Insulin-Degrading Enzyme In
Complex With Amylin
pdb|2G48|B Chain B, Crystal Structure Of Human Insulin-Degrading Enzyme In
Complex With Amylin
pdb|2G49|A Chain A, Crystal Structure Of Human Insulin-Degrading Enzyme In
Complex With Glucagon
pdb|2G49|B Chain B, Crystal Structure Of Human Insulin-Degrading Enzyme In
Complex With Glucagon
pdb|2G54|A Chain A, Crystal Structure Of Zn-Bound Human Insulin-Degrading Enzyme
In Complex With Insulin B Chain
pdb|2G54|B Chain B, Crystal Structure Of Zn-Bound Human Insulin-Degrading Enzyme
In Complex With Insulin B Chain
pdb|2G56|A Chain A, Crystal Structure Of Human Insulin-Degrading Enzyme In
Complex With Insulin B Chain
pdb|2G56|B Chain B, Crystal Structure Of Human Insulin-Degrading Enzyme In
Complex With Insulin B Chain
pdb|2JBU|A Chain A, Crystal Structure Of Human Insulin Degrading Enzyme
Complexed With Co-Purified Peptides.
pdb|2JBU|B Chain B, Crystal Structure Of Human Insulin Degrading Enzyme
Complexed With Co-Purified Peptides.
Length = 990
Score = 701 bits (1808), Expect = 0.0, Method: Composition-based stats.
Identities = 372/965 (38%), Positives = 577/965 (59%), Gaps = 32/965 (3%)
Query: 70 DERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNLPGLAHFCEHLLFMGSE 129
D+R YR +EL N +K LLI DP DK++A+LDV+IG+ DP N+ GL+HFC+H+LF+G++
Sbjct: 31 DKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCQHMLFLGTK 90
Query: 130 KFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGALDRFSGFFSCPLFNKDST 189
K+P ENEYS +LS+H GSSNA+T+ ++TNY+F+V+H+HL GALDRF+ FF CPLF++
Sbjct: 91 KYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCK 150
Query: 190 DKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGTLPKENGLNVRD 249
D+E+NAV+SE++KN+ ND WR++QL+K+ N KHP+ KF TGN TL T P + G++VR
Sbjct: 151 DREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQ 210
Query: 250 ELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGREVPLYAEPIMQPEHLQ 309
ELLKFH +YS+NLM +C+LGRE LD L++ LF +V N +P + E Q EHL+
Sbjct: 211 ELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLK 270
Query: 310 KIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGSGSLLAHLKKLGWANEL 369
++ ++ P+KD++ L ++F +PD++++++S P L HLIGHEG GSLL+ LK GW N L
Sbjct: 271 QLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTL 330
Query: 370 SAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLPQKWIFNELQDISN 429
G ++G FF +++DLT+ GL H D+I+ +FQYI+ L+ PQ+W+F E +D++
Sbjct: 331 VGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNA 390
Query: 430 ATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRIL-AMGLLTKYEPDLLTQYTDALVPENSR 488
F+FK P S +A L Y P+ +L A LL ++ PDL+ D L PEN R
Sbjct: 391 VAFRFKDKERPRGYTSKIAGILH--YYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVR 448
Query: 489 VTLISRSLE--TDSAEKWYGTAYKVVDYPADLIKNMKSPGLNPALTLPRPNEFVSTNFKV 546
V ++S+S E TD E+WYGT YK P ++IK ++ LN LP NEF+ TNF+
Sbjct: 449 VAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFE- 507
Query: 547 DKIDGIKPLDE-----PVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLPHTHASIINSM 601
I PL++ P L+ +SKLW+K+DD+F+ P+ + F P + ++
Sbjct: 508 -----ILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCN 562
Query: 602 LSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLIILLTRFLQGVNS 661
++ LY +L D+L + Y A A L T G+ ++ G+N+K ILL + ++ + +
Sbjct: 563 MAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMAT 622
Query: 662 FEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKLQVFEKLTFEQ 721
FE + RFEI+K+ +R L N E P+ Y ++ E +W+ E + + +T +
Sbjct: 623 FEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPR 682
Query: 722 LINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIHN---LQVSNNRLRSYLL 778
L FIP + ++ E L+HGNI + AL + +++ + + H L R R L
Sbjct: 683 LKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQL 742
Query: 779 PKGKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFAQLIHEPCFDTLRTKEQL 838
P F Y+ ++ + N I+ Q D+ S + LF Q+I EPCF+TLRTKEQL
Sbjct: 743 PDRGWFVYQQ--RNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQL 800
Query: 839 GYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVLRDMPEEDFEKHKEAL 898
GY+VFS +G +R +IQSE YLE R+ F T + + DM EE F+KH +AL
Sbjct: 801 GYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQAL 860
Query: 899 CNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMIDFYENYIM--SE 956
L K K ++ E A+Y I YNF + + +TK+ +I FY+ + +
Sbjct: 861 AIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAP 920
Query: 957 NASKLILHLKSQ------VENKELNENELDTAK---YPTGQLIEDVGAFKSTLFVAPVRQ 1007
K+ +H+ ++ V + +N+++ ++ P ++I+++ FK L + P+ +
Sbjct: 921 RRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVK 980
Query: 1008 PMKDF 1012
P +F
Sbjct: 981 PHINF 985
>pdb|2JG4|A Chain A, Substrate-Free Ide Structure In Its Closed Conformation
pdb|2JG4|B Chain B, Substrate-Free Ide Structure In Its Closed Conformation
Length = 990
Score = 701 bits (1808), Expect = 0.0, Method: Composition-based stats.
Identities = 372/965 (38%), Positives = 577/965 (59%), Gaps = 32/965 (3%)
Query: 70 DERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNLPGLAHFCEHLLFMGSE 129
D+R YR +EL N +K LLI DP DK++A+LDV+IG+ DP N+ GL+HFCEH+LF+G++
Sbjct: 31 DKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTK 90
Query: 130 KFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGALDRFSGFFSCPLFNKDST 189
K+P ENEYS +LS+H GSSNA+T+ ++TNY+F+V+H+HL GALDRF+ FF CPLF++
Sbjct: 91 KYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCK 150
Query: 190 DKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGTLPKENGLNVRD 249
D+E+NAV+SE++KN+ ND WR++QL+K+ N KHP+ KF TGN TL T P + G++VR
Sbjct: 151 DREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQ 210
Query: 250 ELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGREVPLYAEPIMQPEHLQ 309
ELLKFH +YS+NLM +C+LGRE LD L++ LF +V N +P + E Q EHL+
Sbjct: 211 ELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLK 270
Query: 310 KIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGSGSLLAHLKKLGWANEL 369
++ ++ P+KD++ L ++F +PD++++++S P L HLIGHEG GSLL+ LK GW N L
Sbjct: 271 QLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTL 330
Query: 370 SAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLPQKWIFNELQDISN 429
G ++G FF +++DLT+ GL H D+I+ +FQYI+ L+ PQ+W+F E +D++
Sbjct: 331 VGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNA 390
Query: 430 ATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRIL-AMGLLTKYEPDLLTQYTDALVPENSR 488
F+FK P S +A L Y P+ +L A LL ++ PDL+ D L PEN R
Sbjct: 391 VAFRFKDKERPRGYTSKIAGILH--YYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVR 448
Query: 489 VTLISRSLE--TDSAEKWYGTAYKVVDYPADLIKNMKSPGLNPALTLPRPNEFVSTNFKV 546
V ++S+S E TD E+WYGT YK P ++IK ++ LN LP NEF+ TNF+
Sbjct: 449 VAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFE- 507
Query: 547 DKIDGIKPLDE-----PVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLPHTHASIINSM 601
I PL++ P L+ +SKLW+K+DD+F+ P+ + F P + ++
Sbjct: 508 -----ILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCN 562
Query: 602 LSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLIILLTRFLQGVNS 661
++ LY +L D+L + Y A A L T G+ ++ G+N+K ILL + ++ + +
Sbjct: 563 MAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMAT 622
Query: 662 FEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKLQVFEKLTFEQ 721
FE + RFEI+K+ +R L N E P+ Y ++ E +W+ E + + +T +
Sbjct: 623 FEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPR 682
Query: 722 LINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIHN---LQVSNNRLRSYLL 778
L FIP + ++ E L+HGNI + AL + +++ + + H L R R L
Sbjct: 683 LKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQL 742
Query: 779 PKGKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFAQLIHEPCFDTLRTKEQL 838
P F Y+ ++ + N I+ Q D+ S + LF Q+I EPCF+TLRTKEQL
Sbjct: 743 PDRGWFVYQQ--RNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQL 800
Query: 839 GYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVLRDMPEEDFEKHKEAL 898
G++VFS +G +R +IQSE YLE R+ F T + + DM EE F+KH +AL
Sbjct: 801 GFIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQAL 860
Query: 899 CNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMIDFYENYIM--SE 956
L K K ++ E A+Y I YNF + + +TK+ +I FY+ + +
Sbjct: 861 AIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAP 920
Query: 957 NASKLILHLKSQ------VENKELNENELDTAK---YPTGQLIEDVGAFKSTLFVAPVRQ 1007
K+ +H+ ++ V + +N+++ ++ P ++I+++ FK L + P+ +
Sbjct: 921 RRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVK 980
Query: 1008 PMKDF 1012
P +F
Sbjct: 981 PHINF 985
>ref|XP_001090249.1| PREDICTED: insulysin isoform 3 [Macaca mulatta]
Length = 1019
Score = 700 bits (1807), Expect = 0.0, Method: Composition-based stats.
Identities = 372/965 (38%), Positives = 577/965 (59%), Gaps = 32/965 (3%)
Query: 70 DERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNLPGLAHFCEHLLFMGSE 129
D+R YR +EL N +K LLI DP DK++A+LDV+IG+ DP N+ GL+HFCEH+LF+G++
Sbjct: 60 DKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTK 119
Query: 130 KFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGALDRFSGFFSCPLFNKDST 189
K+P ENEYS +LS+H GSSNA+T+ ++TNY+F+V+H+HL GALDRF+ FF CPLF++
Sbjct: 120 KYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCK 179
Query: 190 DKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGTLPKENGLNVRD 249
D+E+NAV+SE++KN+ ND WR++QL+K+ N KHP+ KF TGN TL T P + G++VR
Sbjct: 180 DREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQ 239
Query: 250 ELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGREVPLYAEPIMQPEHLQ 309
ELLKFH +YS+NLM +C+LGRE LD L++ LF +V N +P + E Q EHL+
Sbjct: 240 ELLKFHSTYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKSVPLPEFPEHPFQEEHLK 299
Query: 310 KIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGSGSLLAHLKKLGWANEL 369
++ ++ P+KD++ L ++F +PD++++++S P L HLIGHEG GSLL+ LK GW N L
Sbjct: 300 QLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTL 359
Query: 370 SAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLPQKWIFNELQDISN 429
G ++G FF +++DLT+ GL H D+I+ +FQYI+ L+ PQ+W+F E +D++
Sbjct: 360 VGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNA 419
Query: 430 ATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRIL-AMGLLTKYEPDLLTQYTDALVPENSR 488
F+FK P S +A L Y P+ +L A LL ++ PDL+ D L PEN R
Sbjct: 420 VAFRFKDKERPRGYTSKIAGILH--YYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVR 477
Query: 489 VTLISRSLE--TDSAEKWYGTAYKVVDYPADLIKNMKSPGLNPALTLPRPNEFVSTNFKV 546
V ++S+S E TD E+WYGT YK P ++IK ++ LN LP NEF+ TNF+
Sbjct: 478 VAVVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFE- 536
Query: 547 DKIDGIKPLDE-----PVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLPHTHASIINSM 601
I PL++ P L+ +SKLW+K+DD+F+ P+ + F P + ++
Sbjct: 537 -----ILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCN 591
Query: 602 LSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLIILLTRFLQGVNS 661
++ LY +L D+L + Y A A L T G+ ++ G+N+K ILL + ++ + +
Sbjct: 592 MAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMAT 651
Query: 662 FEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKLQVFEKLTFEQ 721
FE + RFEI+K+ +R L N E P+ Y ++ E +W+ E + + +T +
Sbjct: 652 FEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPR 711
Query: 722 LINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIHN---LQVSNNRLRSYLL 778
L FIP + ++ E L+HGNI + AL + +++ + + H L R R L
Sbjct: 712 LKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQL 771
Query: 779 PKGKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFAQLIHEPCFDTLRTKEQL 838
P F Y+ ++ + N I+ Q D+ S + LF Q+I EPCF+TLRTKEQL
Sbjct: 772 PDRGWFVYQQ--RNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQL 829
Query: 839 GYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVLRDMPEEDFEKHKEAL 898
GY+VFS +G +R +IQSE YLE R+ F T + + DM EE F+KH +AL
Sbjct: 830 GYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQAL 889
Query: 899 CNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMIDFYENYIM--SE 956
L K K ++ E A+Y I Y+F + + +TK+ +I FY+ + +
Sbjct: 890 AIRRLDKPKKLSAECAKYWGEIISQQYHFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAP 949
Query: 957 NASKLILHLKSQ------VENKELNENELDTAK---YPTGQLIEDVGAFKSTLFVAPVRQ 1007
K+ +H+ ++ V + +N+++ ++ P ++I+++ FK L + P+ +
Sbjct: 950 RRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVK 1009
Query: 1008 PMKDF 1012
P +F
Sbjct: 1010 PHINF 1014
>ref|XP_001090137.1| PREDICTED: insulysin isoform 2 [Macaca mulatta]
Length = 978
Score = 700 bits (1806), Expect = 0.0, Method: Composition-based stats.
Identities = 372/965 (38%), Positives = 577/965 (59%), Gaps = 32/965 (3%)
Query: 70 DERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNLPGLAHFCEHLLFMGSE 129
D+R YR +EL N +K LLI DP DK++A+LDV+IG+ DP N+ GL+HFCEH+LF+G++
Sbjct: 19 DKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTK 78
Query: 130 KFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGALDRFSGFFSCPLFNKDST 189
K+P ENEYS +LS+H GSSNA+T+ ++TNY+F+V+H+HL GALDRF+ FF CPLF++
Sbjct: 79 KYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCK 138
Query: 190 DKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGTLPKENGLNVRD 249
D+E+NAV+SE++KN+ ND WR++QL+K+ N KHP+ KF TGN TL T P + G++VR
Sbjct: 139 DREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQ 198
Query: 250 ELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGREVPLYAEPIMQPEHLQ 309
ELLKFH +YS+NLM +C+LGRE LD L++ LF +V N +P + E Q EHL+
Sbjct: 199 ELLKFHSTYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKSVPLPEFPEHPFQEEHLK 258
Query: 310 KIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGSGSLLAHLKKLGWANEL 369
++ ++ P+KD++ L ++F +PD++++++S P L HLIGHEG GSLL+ LK GW N L
Sbjct: 259 QLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTL 318
Query: 370 SAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLPQKWIFNELQDISN 429
G ++G FF +++DLT+ GL H D+I+ +FQYI+ L+ PQ+W+F E +D++
Sbjct: 319 VGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNA 378
Query: 430 ATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRIL-AMGLLTKYEPDLLTQYTDALVPENSR 488
F+FK P S +A L Y P+ +L A LL ++ PDL+ D L PEN R
Sbjct: 379 VAFRFKDKERPRGYTSKIAGILH--YYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVR 436
Query: 489 VTLISRSLE--TDSAEKWYGTAYKVVDYPADLIKNMKSPGLNPALTLPRPNEFVSTNFKV 546
V ++S+S E TD E+WYGT YK P ++IK ++ LN LP NEF+ TNF+
Sbjct: 437 VAVVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFE- 495
Query: 547 DKIDGIKPLDE-----PVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLPHTHASIINSM 601
I PL++ P L+ +SKLW+K+DD+F+ P+ + F P + ++
Sbjct: 496 -----ILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCN 550
Query: 602 LSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLIILLTRFLQGVNS 661
++ LY +L D+L + Y A A L T G+ ++ G+N+K ILL + ++ + +
Sbjct: 551 MAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMAT 610
Query: 662 FEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKLQVFEKLTFEQ 721
FE + RFEI+K+ +R L N E P+ Y ++ E +W+ E + + +T +
Sbjct: 611 FEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPR 670
Query: 722 LINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIHN---LQVSNNRLRSYLL 778
L FIP + ++ E L+HGNI + AL + +++ + + H L R R L
Sbjct: 671 LKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQL 730
Query: 779 PKGKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFAQLIHEPCFDTLRTKEQL 838
P F Y+ ++ + N I+ Q D+ S + LF Q+I EPCF+TLRTKEQL
Sbjct: 731 PDRGWFVYQQ--RNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQL 788
Query: 839 GYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVLRDMPEEDFEKHKEAL 898
GY+VFS +G +R +IQSE YLE R+ F T + + DM EE F+KH +AL
Sbjct: 789 GYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQAL 848
Query: 899 CNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMIDFYENYIM--SE 956
L K K ++ E A+Y I Y+F + + +TK+ +I FY+ + +
Sbjct: 849 AIRRLDKPKKLSAECAKYWGEIISQQYHFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAP 908
Query: 957 NASKLILHLKSQ------VENKELNENELDTAK---YPTGQLIEDVGAFKSTLFVAPVRQ 1007
K+ +H+ ++ V + +N+++ ++ P ++I+++ FK L + P+ +
Sbjct: 909 RRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVK 968
Query: 1008 PMKDF 1012
P +F
Sbjct: 969 PHINF 973
>sp|Q9JHR7|IDE_MOUSE Insulin-degrading enzyme (Insulysin) (Insulinase) (Insulin protease)
emb|CAC01233.1| insulin degrading enzyme [Mus musculus]
Length = 1019
Score = 699 bits (1803), Expect = 0.0, Method: Composition-based stats.
Identities = 371/965 (38%), Positives = 575/965 (59%), Gaps = 22/965 (2%)
Query: 65 LKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNLPGLAHFCEHLL 124
+K D+R YR +EL N +K LLI DP DK++A+LDV+IG+ DP N+PGL+HFCEH+L
Sbjct: 55 VKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIPGLSHFCEHML 114
Query: 125 FMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGALDRFSGFFSCPLF 184
F+G++K+P ENEYS +LS+H GSSNA+T+ ++TNY+F+V+H+HL GALDRF+ FF CPL
Sbjct: 115 FLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLL 174
Query: 185 NKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGTLPKENG 244
+ D+E+NAV+SE++KN+ ND WR++QL+K+ N KHP+ KF TGN TL T P + G
Sbjct: 175 DASCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEG 234
Query: 245 LNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGREVPLYAEPIMQ 304
++VR+ELLKFH +YS+NLM +C+LGRE LD L++ LF +V N +P + E Q
Sbjct: 235 IDVREELLKFHSTYYSSNLMAICVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQ 294
Query: 305 PEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGSGSLLAHLKKLG 364
EHL+++ ++ P+KD++ L ++F +PD++++++S P L HLIGHEG GSLL+ LK G
Sbjct: 295 EEHLRQLYKIVPIKDIRNLYVTFPIPDLQQYYKSNPGYYLGHLIGHEGPGSLLSELKSKG 354
Query: 365 WANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLPQKWIFNEL 424
W N L G ++G FF +++DLT+ GL H D+I+ +FQYI+ L+ PQ+W+F E
Sbjct: 355 WVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQEC 414
Query: 425 QDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRIL-AMGLLTKYEPDLLTQYTDALV 483
+D++ F+FK P S +A L Y P++ +L A LL ++ PDL+ D L
Sbjct: 415 KDLNAVAFRFKDKERPRGYTSKIAGKLH--YYPLNGVLTAEYLLEEFRPDLIDMVLDKLR 472
Query: 484 PENSRVTLISRSLE--TDSAEKWYGTAYKVVDYPADLIKNMKSPGLNPALTLPRPNEFVS 541
PEN RV ++S+S E TD E+WYGT YK P D+I+ ++ LN LP NEF+
Sbjct: 473 PENVRVAIVSKSFEGKTDRTEQWYGTQYKQEAIPEDVIQKWQNADLNGKFKLPTKNEFIP 532
Query: 542 TNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLPHTHASIINSM 601
TNF++ ++ P L+ +SKLW+K+DD+F+ P+ + F P + ++
Sbjct: 533 TNFEILSLEK-DATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCN 591
Query: 602 LSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLIILLTRFLQGVNS 661
++ LY +L D+L + Y A A L T G+ ++ +N+K ILL + + + +
Sbjct: 592 MAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKRYNDKQPILLKKITEKMAT 651
Query: 662 FEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKLQVFEKLTFEQ 721
FE K RFEI+K+ +R L N E P+ Y ++ E +W+ E + + +T +
Sbjct: 652 FEIDKKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPR 711
Query: 722 LINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIHN---LQVSNNRLRSYLL 778
L FIP + ++ E L+HGNI + AL V +++ + + H L R R L
Sbjct: 712 LKAFIPQLLSRLHIEALLHGNITKQAALGVMQMVEDTLIEHAHTKPLLPSQLVRYREVQL 771
Query: 779 PKGKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFAQLIHEPCFDTLRTKEQL 838
P F Y+ ++ + N I+ Q D+ S + LF Q+I EPCF+TLRTKEQL
Sbjct: 772 PDRGWFVYQQ--RNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQL 829
Query: 839 GYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVLRDMPEEDFEKHKEAL 898
GY+VFS +G +R +IQSE YLE R+ F T + + DM EE F+KH +AL
Sbjct: 830 GYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKAIEDMTEEAFQKHIQAL 889
Query: 899 CNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMIDFYENYIM--SE 956
L K K ++ E A+Y I YN+ + + +TK +I FY+ + +
Sbjct: 890 AIRRLDKPKKLSAECAKYWGEIISQQYNYDRDNIEVAYLKTLTKDDIIRFYQEMLAVDAP 949
Query: 957 NASKLILHLKSQ------VENKELNENELDTAK---YPTGQLIEDVGAFKSTLFVAPVRQ 1007
K+ +H+ ++ V + ++N+++ ++ P ++I ++ FK L + P+ +
Sbjct: 950 RRHKVSVHVLAREMDSCPVVGEFPSQNDINLSEAPPLPQPEVIHNMTEFKRGLPLFPLVK 1009
Query: 1008 PMKDF 1012
P +F
Sbjct: 1010 PHINF 1014
>ref|XP_001820380.1| hypothetical protein [Aspergillus oryzae RIB40]
dbj|BAE58378.1| unnamed protein product [Aspergillus oryzae]
Length = 1108
Score = 698 bits (1802), Expect = 0.0, Method: Composition-based stats.
Identities = 386/973 (39%), Positives = 572/973 (58%), Gaps = 56/973 (5%)
Query: 59 TFNLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNLPGLAH 118
T NLD KP+LD+RSYR I LPNKL+ALL+ DP DKA+A+++VN+G F D ++PG+AH
Sbjct: 8 TENLD--KPELDDRSYRVIRLPNKLEALLVHDPDTDKASAAVNVNVGNFSDADDMPGMAH 65
Query: 119 FCEHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVN-------------- 164
EHLLFMG+EK+P EN Y+ YL+ H GSSNAYTA+ TNYFFEV+
Sbjct: 66 AVEHLLFMGTEKYPKENAYNQYLASHSGSSNAYTAATETNYFFEVSATSESSDGSSSGNS 125
Query: 165 ----------------------HQHLFGALDRFSGFFSCPLFNKDSTDKEINAVNSENKK 202
L+GALDRF+ FF PLF + + D+E+ AV+SENKK
Sbjct: 126 TPTNGTTPTGQTESSKSPNSSKPSPLYGALDRFAQFFVAPLFLESTLDRELRAVDSENKK 185
Query: 203 NLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGTLPKENGLNVRDELLKFHKNFYSAN 262
NLQ+D+WR+ QL+KSL+N HPYH FSTGN++TL P++ GLNVRDE +KF++ YS+N
Sbjct: 186 NLQSDLWRLMQLNKSLSNPAHPYHHFSTGNLQTLKEEPQKRGLNVRDEFIKFYEKHYSSN 245
Query: 263 LMKLCILGREDLDTLSDWTYDLFKDVANNGREVPLYAEPIMQP---EHLQKIIQVRPVKD 319
MKL +LGRE LD + W DLF V N + +P +QP + + K + +PV D
Sbjct: 246 RMKLVVLGRETLDEMEQWVGDLFAGVKN--KNLPQNRWDDVQPWLADDMCKQVFAKPVMD 303
Query: 320 LKKLEISFTVPDMEEHWESKPPRILSHLIGHEGSGSLLAHLKKLGWANELSAGGHTVSKG 379
+ L+I F D E +ES+P R +SHLIGHEG GS+LA++K GWAN LSAG + G
Sbjct: 304 TRSLDIYFPFLDEEHMYESQPSRYISHLIGHEGPGSILAYVKAKGWANGLSAGVMPICPG 363
Query: 380 NAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLPQKWIFNELQDISNATFKFKQAGS 439
+AFF V I LT GL YR+V +F+YI ++K P++WIF+E+++++ F+FKQ
Sbjct: 364 SAFFTVSIRLTKEGLRQYREVAKAVFEYIALIKEREPEQWIFDEMKNLAEVEFRFKQKTP 423
Query: 440 PSSTVSSLAKCLEKDYIPVSRILAMGLLTKYEPDLLTQYTDALVPENSRVTLISRSL--E 497
S S L+ ++K +P +L+ LL Y+P+L+ + L +N R+ ++++ +
Sbjct: 424 ASRFTSRLSSVMQKP-LPRDWLLSGSLLRSYKPELIKKALSYLRADNFRMVVVAQDYPGD 482
Query: 498 TDSAEKWYGTAYKVVDYPADLIKNMK-----SPGLNPA-LTLPRPNEFVSTNFKVDKIDG 551
D EKWYGT YKV D P D + ++ +P + L +P NEFV T V+K +
Sbjct: 483 WDLKEKWYGTEYKVEDVPKDFLGEIQEALKSTPETRHSDLHMPHKNEFVPTRLSVEKKEV 542
Query: 552 IKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLPHTHASIINSMLSTLYTQLAN 611
+P P L+ DD +LW+KKDDRFW P+ ++++ + A+ N + S Y +L
Sbjct: 543 SEPAKTPKLIRHDDQVRLWFKKDDRFWVPKATLHVTLRNLLVWATPANLVKSKFYCELVR 602
Query: 612 DALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLIILLTRFLQGVNSFEPKKDRFEI 671
DAL + YDA A L + + + GL ++ G+N+K+ +LL + L + DRF +
Sbjct: 603 DALVEYSYDAELAGLDYNLSASIFGLDVSVGGYNDKMAVLLEKVLTSMRDLVVNPDRFHV 662
Query: 672 LKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKLQVFEKLTFEQLINFIPTIYE 731
+K++ R KN Y+ P+ Q+ +Y + E++W + E + + F P +
Sbjct: 663 IKERLSRGYKNAEYQQPFYQVGDYTRYLTAEKAWLNEQYASELEHIEPNDISCFFPQLLR 722
Query: 732 GVYFETLIHGNIKHEEALEVDSLIKSLIPNNIHNLQVSNNRLRSYLLPKGKTFRYETALK 791
+ E L HGN+ E+AL + ++S++ + + R R+ ++P G F YE ALK
Sbjct: 723 QNHIEVLAHGNLYKEDALRMTDSVESILQSRPLPQSQWHVR-RNVIIPPGSDFVYERALK 781
Query: 792 DSQNVNSCIQHVTQLDVYSED-LSALSGLFAQLIHEPCFDTLRTKEQLGYVVFSSSLNNH 850
D NVN CI++ + ++D L A LFAQ+ EP FD LR+KEQLGYVV+S + +
Sbjct: 782 DPANVNHCIEYYLFVGNMTDDALRAKLLLFAQMTDEPAFDQLRSKEQLGYVVWSGARYSA 841
Query: 851 GTANIRILIQSEHTTPYLEWRINNFYETFGQVLRDMPEEDFEKHKEALCNSLLQKFKNMA 910
T R++IQSE T YLE RIN F FG+ L +M +E+FE HK ++ N L+K KN+
Sbjct: 842 TTIGYRVIIQSERTAQYLESRINAFLSNFGKALEEMSDEEFEGHKRSVVNKRLEKLKNLG 901
Query: 911 EESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMIDFYENYIMSENAS--KLILHLKSQ 968
E+ R+ + ++F + A V ++K +I+FY+ YI E+ + KL +HLK+Q
Sbjct: 902 SETTRFWTHVGSEYFDFLQNESDAANVRTLSKSDLIEFYQQYIAPESTTRGKLSVHLKAQ 961
Query: 969 VENKELNENELDT 981
NE ++
Sbjct: 962 AGADTTEPNEQNS 974
>ref|XP_001146582.1| PREDICTED: insulysin isoform 3 [Pan troglodytes]
Length = 1019
Score = 694 bits (1792), Expect = 0.0, Method: Composition-based stats.
Identities = 370/965 (38%), Positives = 576/965 (59%), Gaps = 32/965 (3%)
Query: 70 DERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNLPGLAHFCEHLLFMGSE 129
D+R YR +EL N +K LLI DP DK++A+LDV+IG+ DP N+ GL+HFCEH+LF+G++
Sbjct: 60 DKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTK 119
Query: 130 KFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGALDRFSGFFSCPLFNKDST 189
K+P ENEYS +LS+H GSSNA+T+ ++TNY+F+V+H+HL GALDRF+ FF CPLF++
Sbjct: 120 KYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCK 179
Query: 190 DKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGTLPKENGLNVRD 249
D+E+NAV+SE++KN+ ND WR++QL+K+ N KHP+ KF TGN TL T P + G++VR
Sbjct: 180 DREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQ 239
Query: 250 ELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGREVPLYAEPIMQPEHLQ 309
ELLKFH +YS+NLM +C+LGRE LD L++ LF +V N +P + E Q EHL+
Sbjct: 240 ELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLK 299
Query: 310 KIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGSGSLLAHLKKLGWANEL 369
++ ++ P+KD++ L ++F +PD++++++S P L HLIGHEG GSLL+ LK GW N L
Sbjct: 300 QLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTL 359
Query: 370 SAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLPQKWIFNELQDISN 429
G ++G FF +++DLT+ GL H D+I+ +FQYI+ L+ PQ+W+F E +D++
Sbjct: 360 VGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNA 419
Query: 430 ATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRIL-AMGLLTKYEPDLLTQYTDALVPENSR 488
F+FK P S +A L Y P+ +L A LL ++ PDL+ D L PEN R
Sbjct: 420 VAFRFKDKERPRGYTSKIAGILH--YYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVR 477
Query: 489 VTLISRSLE--TDSAEKWYGTAYKVVDYPADLIKNMKSPGLNPALTLPRPNEFVSTNFKV 546
V ++S+S E TD E+WYGT YK P ++IK ++ LN LP NEF+ TNF+
Sbjct: 478 VAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFE- 536
Query: 547 DKIDGIKPLDE-----PVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLPHTHASIINSM 601
I PL++ P L+ +SKLW+K+DD+F+ P+ + F + +A ++
Sbjct: 537 -----ILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSRYIYADPLHCN 591
Query: 602 LSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLIILLTRFLQGVNS 661
++ L+ +L D LK+ Y A + L + ++ G+N+K ILL + ++ + +
Sbjct: 592 MTYLFIRLLKDDLKEYTYAARLSGLSYGIASGMNAILLSVKGYNDKQPILLKKIIEKMAT 651
Query: 662 FEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKLQVFEKLTFEQ 721
FE + RFEI+K+ +R L N E P+ Y ++ E +W+ E + + +T +
Sbjct: 652 FEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPR 711
Query: 722 LINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIHN---LQVSNNRLRSYLL 778
L FIP + ++ E L+HGNI + AL + +++ + + H L R R L
Sbjct: 712 LKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQL 771
Query: 779 PKGKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFAQLIHEPCFDTLRTKEQL 838
P F Y+ ++ + N I+ Q D+ S + LF Q+I EPCF+TLRTKEQL
Sbjct: 772 PDRGWFVYQQ--RNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQL 829
Query: 839 GYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVLRDMPEEDFEKHKEAL 898
GY+VFS +G +R +IQSE YLE R+ F T + + DM EE F+KH +AL
Sbjct: 830 GYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQAL 889
Query: 899 CNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMIDFYENYIM--SE 956
L K K ++ E A+Y I YNF + + +TK+ +I FY+ + +
Sbjct: 890 AIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAP 949
Query: 957 NASKLILHLKSQ------VENKELNENELDTAK---YPTGQLIEDVGAFKSTLFVAPVRQ 1007
K+ +H+ ++ V + +N+++ ++ P ++I+++ FK L + P+ +
Sbjct: 950 RRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVK 1009
Query: 1008 PMKDF 1012
P +F
Sbjct: 1010 PHINF 1014
>pdb|2WBY|A Chain A, Crystal Structure Of Human Insulin-Degrading Enzyme In
Complex With Insulin
pdb|2WBY|B Chain B, Crystal Structure Of Human Insulin-Degrading Enzyme In
Complex With Insulin
pdb|2WC0|A Chain A, Crystal Structure Of Human Insulin Degrading Enzyme In
Complex With Iodinated Insulin
pdb|2WC0|B Chain B, Crystal Structure Of Human Insulin Degrading Enzyme In
Complex With Iodinated Insulin
Length = 990
Score = 688 bits (1776), Expect = 0.0, Method: Composition-based stats.
Identities = 370/960 (38%), Positives = 578/960 (60%), Gaps = 22/960 (2%)
Query: 70 DERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNLPGLAHFCEHLLFMGSE 129
D+R YR +EL N +K LLI DP DK++A+LDV+IG+ DP N+ GL+HF +H+LF+G++
Sbjct: 31 DKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFLQHMLFLGTK 90
Query: 130 KFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGALDRFSGFFSCPLFNKDST 189
K+P ENEYS +LS+H GSSNA+T+ ++TNY+F+V+H+HL GALDRF+ FF PLF++ +
Sbjct: 91 KYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLSPLFDESAK 150
Query: 190 DKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGTLPKENGLNVRD 249
D+E+NAV+SE++KN+ ND WR++QL+K+ N KHP+ KF TGN TL T P + G++VR
Sbjct: 151 DREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQ 210
Query: 250 ELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGREVPLYAEPIMQPEHLQ 309
ELLKFH +YS+NLM + +LGRE LD L++ LF +V N +P + E Q EHL+
Sbjct: 211 ELLKFHSAYYSSNLMAVVVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLK 270
Query: 310 KIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGSGSLLAHLKKLGWANEL 369
++ ++ P+KD++ L ++F +PD++++++S P L HLIGHEG GSLL+ LK GW N L
Sbjct: 271 QLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTL 330
Query: 370 SAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLPQKWIFNELQDISN 429
G ++G FF +++DLT+ GL H D+I+ +FQYI+ L+ PQ+W+F EL+D++
Sbjct: 331 VGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQELKDLNA 390
Query: 430 ATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRIL-AMGLLTKYEPDLLTQYTDALVPENSR 488
F+FK P S +A L Y P+ +L A LL ++ PDL+ D L PEN R
Sbjct: 391 VAFRFKDKERPRGYTSKIAGILH--YYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVR 448
Query: 489 VTLISRSLE--TDSAEKWYGTAYKVVDYPADLIKNMKSPGLNPALTLPRPNEFVSTNFKV 546
V ++S+S E TD E+WYGT YK P ++IK ++ LN LP NEF+ TNF++
Sbjct: 449 VAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEI 508
Query: 547 DKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLPHTHASIINSMLSTLY 606
++ + P L+ +SKLW+K+DD+F+ P+ + F P + ++S ++ LY
Sbjct: 509 LPLEK-EATPYPALIKDTAMSKLWFKQDDKFFLPKANLNFEFFSPFAYVDPLHSNMAYLY 567
Query: 607 TQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLIILLTRFLQGVNSFEPKK 666
+L D+L + Y A A L T G+ ++ G+N+K ILL + ++ + +FE +
Sbjct: 568 LELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDE 627
Query: 667 DRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKLQVFEKLTFEQLINFI 726
RFEI+K+ +R L N E P+ Y ++ E +W+ E + + +T +L FI
Sbjct: 628 KRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFI 687
Query: 727 PTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIHN---LQVSNNRLRSYLLPKGKT 783
P + ++ E L+HGNI + AL + +++ + + H L R R LP
Sbjct: 688 PQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGW 747
Query: 784 FRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFAQLIHEPCFDTLRTKEQLGYVVF 843
F Y+ ++ + NS I+ Q D+ S + LFAQ+I EP F+TLRTKEQLGY+VF
Sbjct: 748 FVYQQ--RNEVHNNSGIEIYYQTDMQSTSENMFLELFAQIISEPAFNTLRTKEQLGYIVF 805
Query: 844 SSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVLRDMPEEDFEKHKEALCNSLL 903
S +G +R +IQSE YLE R+ F T + + DM EE F+KH +AL L
Sbjct: 806 SGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRL 865
Query: 904 QKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMIDFYENYIM--SENASKL 961
K K ++ ESA+Y I YNF + + +TK+ +I FY+ + + K+
Sbjct: 866 DKPKKLSAESAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKV 925
Query: 962 ILHLKSQ------VENKELNENELDTAK---YPTGQLIEDVGAFKSTLFVAPVRQPMKDF 1012
+H+ ++ V + +N+++ ++ P ++I+++ FK L + P+ +P +F
Sbjct: 926 SVHVLAREMDSNPVVGEFPAQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINF 985
>ref|XP_956166.1| hypothetical protein NCU00481 [Neurospora crassa OR74A]
gb|EAA26930.1| hypothetical protein NCU00481 [Neurospora crassa OR74A]
Length = 1082
Score = 688 bits (1775), Expect = 0.0, Method: Composition-based stats.
Identities = 385/938 (41%), Positives = 577/938 (61%), Gaps = 39/938 (4%)
Query: 66 KPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNLPGLAHFCEHLLF 125
KP LD+RSYR I LPNKL+ALL+ DP DKA+A+LDVN+G+F D ++PG+AH EHLLF
Sbjct: 25 KPSLDDRSYRVIRLPNKLEALLVHDPTTDKASAALDVNVGSFSDEDDMPGMAHAVEHLLF 84
Query: 126 MGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEV-------------NHQHLFGAL 172
MG++K+P EN+YS YLS + GSSNA+TA+ +TNY+FEV N L+GAL
Sbjct: 85 MGTKKYPVENDYSQYLSTNSGSSNAFTAATHTNYYFEVSAKPSNDEELSATNPSPLYGAL 144
Query: 173 DRFSGFFSCPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGN 232
DRF+ FF PLF ++ D+E+ AV+SENKKNLQND WR++QLDKS++N KHPY FSTGN
Sbjct: 145 DRFAQFFVAPLFLANTLDRELRAVDSENKKNLQNDTWRLHQLDKSISNPKHPYCHFSTGN 204
Query: 233 IETLGTLPKENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANNG 292
+ETL LP+ G+NVR++ ++F++ YSAN MKLC+LGRE LD L W +LF DV N
Sbjct: 205 LETLKVLPESKGVNVREKFIEFYQKHYSANRMKLCVLGREPLDVLEGWVAELFSDVEN-- 262
Query: 293 REVP---LYAEPIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEH--WESKPPRILSHL 347
+++P E + PE L + +PV D ++L I+F P ++EH +E P R LSHL
Sbjct: 263 KDLPPNEWTDEAPLTPEQLGVVTFAKPVMDSRELNITF--PFLDEHLLFEELPSRYLSHL 320
Query: 348 IGHEGSGSLLAHLKKLGWANELSAGGHTVSKGN-AFFAVDIDLTDNGLTHYRDVIVLIFQ 406
+GHEG GS++AH+K GWAN LSAG TV G+ F + I LT GL +Y +V+ ++FQ
Sbjct: 321 LGHEGPGSIMAHIKSKGWANGLSAGAWTVCPGSPGMFDIQIKLTQEGLKNYEEVVKVVFQ 380
Query: 407 YIEMLKNSLPQKWIFNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILA-MG 465
YI +LK + PQ+WI NE + + + FKFKQ SS S A +++ +P +L+
Sbjct: 381 YIALLKQTGPQEWIHNEQKIMGDIDFKFKQKTQASSFASKTAGVMQRP-LPREWLLSGTS 439
Query: 466 LLTKYEPDLLTQYTDALVPENSRVTLISRSL--ETDSAEKWYGTAYKVVDYPADLIKNMK 523
L KY+ +L+ + D L P+N R++++SR + + + E+WYGT Y V P++L++ +K
Sbjct: 440 KLRKYDANLIRKGLDCLRPDNFRMSIVSREVPGKWEHKERWYGTEYSVSKIPSELMEEIK 499
Query: 524 SPGL------NPALTLPRPNEFVSTNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRF 577
P L LP N+F+ T +V++ + +P P ++ +DD+ + WYKKDD F
Sbjct: 500 KAATISDQERIPDLHLPHKNQFIPTKLEVERKEVKEPALAPRIVRNDDLVRTWYKKDDTF 559
Query: 578 WQPRGYIYLSFKLPHTHASIINSMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGL 637
W P+ + +S K P HAS + + + L+T DAL++ YDA A L + ++GL
Sbjct: 560 WVPKANLIVSMKSPLIHASAESVVKARLFTDHVKDALEEFSYDADLAGLSYLVSLDSRGL 619
Query: 638 AITASGFNEKLIILLTRFLQGVNSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYN 697
+ SG+N+KL +LL R L + E + DRF+I+K++ R +N +VP+ Q+ +
Sbjct: 620 FVEVSGYNDKLPLLLERVLITMRDLEVRDDRFDIIKERLTRAYRNWELQVPWYQVGGFTE 679
Query: 698 AIINERSWSTAEKLQVFEKLTFEQLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKS 757
+ E + E +T + + F + ++ E IHGN+ E+AL++ +++S
Sbjct: 680 WLTAEHDHTIEELAAELPHITSDHVRQFRKALLAQLHMEVYIHGNLYKEDALKLTDMVES 739
Query: 758 -LIPNNIHNLQVSNNRLRSYLLPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSEDL-SA 815
L P + Q LRS +LP G + ++ LKD NVN+CI++ + ++ L A
Sbjct: 740 TLKPRVLPRSQWP--ILRSLVLPPGSNYVWKKTLKDPANVNNCIEYFLYVGDKNDSLIRA 797
Query: 816 LSGLFAQLIHEPCFDTLRTKEQLGYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNF 875
+ L AQ++ EPCFD LRTKEQLGYVVFS + R LIQSE T PYLE RI F
Sbjct: 798 KTLLLAQILQEPCFDQLRTKEQLGYVVFSGVRATSTSYGFRFLIQSEKTAPYLENRIELF 857
Query: 876 YETFGQVLRDMPEEDFEKHKEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAK 935
E + + +M FE HK +L L+K K + +E+ + + I+ Y+F Q+ A
Sbjct: 858 LERMAKWIEEMDPRQFEAHKRSLIVKRLEKPKFLDQETNKQWSQIHSEYYDFEISQRDAA 917
Query: 936 LVANITKQQMIDFYENYI--MSENASKLILHLKSQVEN 971
V +TK+++I+F+++YI S + +KL ++L++Q ++
Sbjct: 918 HVKPLTKEELIEFFKHYIHPSSPSRAKLAIYLEAQAKS 955
>gb|ABH09708.1| STE23-like protein [Penicillium marneffei]
Length = 1038
Score = 686 bits (1770), Expect = 0.0, Method: Composition-based stats.
Identities = 386/1018 (37%), Positives = 590/1018 (57%), Gaps = 75/1018 (7%)
Query: 66 KPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNLPGLAHFCEHLLF 125
KP+LD+RSYR I+L N+L+ALL+ DP DKA+AS +VN+G F D + +PG+AH EHLLF
Sbjct: 15 KPELDDRSYRVIKLGNQLEALLVHDPDTDKASASANVNVGNFSDEEAMPGMAHAVEHLLF 74
Query: 126 MGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNH-------------------- 165
MG+EK+P EN Y+ YL+ H GSSNAYT + TNYFFEV
Sbjct: 75 MGTEKYPKENAYNQYLASHSGSSNAYTGAIETNYFFEVAATGESKSPESANGEKSAVSSS 134
Query: 166 ----------QHLFGALDRFSGFFSCPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLD 215
L+GALDRF+ FF PLF + + D+E+ AV+SENKKNLQ+D+WR+ QL+
Sbjct: 135 TTALSKDSATSPLYGALDRFAQFFIAPLFLESTLDRELRAVDSENKKNLQSDVWRLMQLN 194
Query: 216 KSLTNTKHPYHKFSTGNIETLGTLPKENGLNVRDELLKFHKNFYSANLMKLCILGREDLD 275
KSL+N +HPYHKFSTGN++TL P+ G+ VR + ++FHK YSAN MKL +LGRE LD
Sbjct: 195 KSLSNPEHPYHKFSTGNLQTLRDDPQSRGVEVRSKFIEFHKKHYSANRMKLVVLGRESLD 254
Query: 276 TLSDWTYDLFKDVANNGREVPLYAEPIMQP---EHLQKIIQVRPVKDLKKLEISFTVPDM 332
L W +LF +V N + +P +QP + L + +PV D + L+I F D
Sbjct: 255 QLESWVVELFSEVQN--KNLPQNRWDDVQPLSADQLCTQVFAKPVMDSRSLDIYFPFLDE 312
Query: 333 EEHWESKPPRILSHLIGHEGSGSLLAHLKKLGWANELSAGGHTVSKGNAFFAVDIDLTDN 392
+E +E+ P R +SHLIGHEG GS+L+++K GWAN LSAG +V G+AFF + + LT++
Sbjct: 313 DELYETLPSRYISHLIGHEGPGSILSYIKAKGWANGLSAGAMSVGPGSAFFTISVRLTED 372
Query: 393 GLTHYRDVIVLIFQYIEMLKNSLPQKWIFNELQDISNATFKFKQAGSPSSTVSSLAKCLE 452
GLTHY++++ +IFQ+I M+K P+KWI++E+Q+++ F+FKQ S S L+ ++
Sbjct: 373 GLTHYKEIVKIIFQHIAMIKERAPEKWIYDEMQNLAEVEFRFKQKSPASRFTSRLSSVMQ 432
Query: 453 KDYIPVSRILA-MGLLTKYEPDLLTQYTDALVPENSRVTLISRSL--ETDSAEKWYGTAY 509
K +P +L+ LL K++ DL+T+ L +N R+ ++S+ + D+ EKWYGT Y
Sbjct: 433 KP-LPREWLLSGNNLLRKFDADLITKALSYLRSDNFRLMIVSQHFPGDWDAKEKWYGTDY 491
Query: 510 KVVDYPADLIKNMKSP-GLNPA-----LTLPRPNEFVSTNFKVDKIDGIKPLDEPVLLLS 563
K P D + +++ P+ L +P NEF+ T V+K + +P P L+
Sbjct: 492 KEEKIPQDFLTEIRNALASAPSERVSDLHMPHKNEFIPTRLSVEKKEVAQPAPTPKLIRL 551
Query: 564 DDVSKLWYKKDDRFWQPRGYIYLSFKLPHTHASIINSMLSTLYTQLANDALKDVQYDAAC 623
DD ++WYKKDDRFW P+ ++++ + A+ N + + LY +L DAL + YDA
Sbjct: 552 DDHVRVWYKKDDRFWVPKATVHITLRNSLVWATPANHVKAKLYCELVRDALVEYSYDAEL 611
Query: 624 ADLRISFNKTNQGLAITASGFNEKLIILLTRFLQGVNSFEPKKDRFEILKDKTIRHLKNL 683
A L + + + GL ++ G+N+K+ +LL + + + DRF+I+K++ R +N
Sbjct: 612 AGLDYNLSASIFGLDVSVGGYNDKMSVLLEKVVTTMRDLVVLPDRFKIIKERLTRAYRNA 671
Query: 684 LYEVPYSQMSNYYNAIINERSWSTAEKLQVFEKLTFEQLINFIPTIYEGVYFETLIHGNI 743
Y+ PY Q+ + + E++W + E + + + F P + + E L HGN+
Sbjct: 672 EYQQPYYQVGDMTRYLTAEKTWINEQYAAELEHIEADDVAAFFPQLLRQNHIEVLAHGNL 731
Query: 744 KHEEALEVDSLIKSLIPNNIHNLQVSNNRLRSYLLPKGKTFRYETALKDSQNVNSCIQHV 803
E+AL++ ++++++ + + R R+ + P G + YE LKD QNVN+CI++
Sbjct: 732 YKEDALKMTDIVENIMRSRTLPQSQWHVR-RNIIFPPGSNYIYERQLKDPQNVNNCIEYY 790
Query: 804 TQL-DVYSEDLSALSGLFAQLIHEPCFDTLRTKEQLGYVVFSSSLNNHGTANIRILIQSE 862
+ + E L A L AQ+ EP FD LR+KEQLGYVV+S + + T R++IQSE
Sbjct: 791 LFVGKITDEVLRAKLLLLAQMTEEPAFDQLRSKEQLGYVVWSGARYSATTIGYRVIIQSE 850
Query: 863 HTTPYLEWRINNFYETFGQVLRDMPEEDFEKHKEALCNSLLQKFKNMAEESARYTAAIYL 922
T YLE RI+NF F + L +M EE+FE HK ++ N L+K KN+ E++R+ I
Sbjct: 851 RTAQYLEGRIDNFLAQFAKTLDEMTEEEFESHKRSIINKRLEKLKNLGSETSRFWTHIGS 910
Query: 923 GDYNFTHRQKKAKLVANITKQQMIDFYENYI--MSENASKLILHLKS------------- 967
+NF + A V +TK ++ F+ YI SE +K+ +HL +
Sbjct: 911 EYFNFLQHEVDAATVRTLTKPDIVAFFRQYIDPSSETRAKISIHLNAQSAKTDELPVDTS 970
Query: 968 -----------QVENKELNENELDTAKYPTGQ--LIEDVGAFKSTLFVAPVRQPMKDF 1012
Q+ N L+ ++ T K + Q I +V FK+ L V+P P+ D
Sbjct: 971 ETAEGAESLHNQLTNVSLSNGDVTTIKTTSRQPIYITNVPQFKARLPVSPGPSPVVDL 1028
>sp|P14735|IDE_HUMAN Insulin-degrading enzyme (Insulysin) (Insulinase) (Insulin protease)
gb|AAA52712.1| insulin-degrading enzyme
Length = 1019
Score = 682 bits (1761), Expect = 0.0, Method: Composition-based stats.
Identities = 371/965 (38%), Positives = 577/965 (59%), Gaps = 32/965 (3%)
Query: 70 DERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNLPGLAHFCEHLLFMGSE 129
D+R YR +EL N +K LL+ DP DK++A+LDV+IG+ DP N+ GL+HFCEH+LF+G++
Sbjct: 60 DKREYRGLELANGIKVLLMSDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTK 119
Query: 130 KFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGALDRFSGFFSCPLFNKDST 189
K+P ENEYS +LS+H GSSNA+T+ ++TNY+F+V+H+HL GALDRF+ FF CPLF++
Sbjct: 120 KYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCK 179
Query: 190 DKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGTLPKENGLNVRD 249
D+E+NAV+SE++KN+ ND WR++QL+K+ N KHP+ KF TGN TL T P + G++VR
Sbjct: 180 DREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQ 239
Query: 250 ELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGREVPLYAEPIMQPEHLQ 309
ELLKFH +YS+NLM +C+LGRE LD L++ LF +V N +P + E Q EHL+
Sbjct: 240 ELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLK 299
Query: 310 KIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGSGSLLAHLKKLGWANEL 369
++ ++ P+KD++ L ++F +PD++++++S P L HLIGHEG GSLL+ LK GW N L
Sbjct: 300 QLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTL 359
Query: 370 SAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLPQKWIFNELQDISN 429
G ++G FF +++DLT+ GL H D+I+ +FQYI+ L+ PQ+W+F E +D++
Sbjct: 360 VGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNA 419
Query: 430 ATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRIL-AMGLLTKYEPDLLTQYTDALVPENSR 488
F+FK P S +A L Y P+ +L A LL ++ PDL+ D L PEN R
Sbjct: 420 VAFRFKDKERPRGYTSKIAGILH--YYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVR 477
Query: 489 VTLISRSLE--TDSAEKWYGTAYKVVDYPADLIKNMKSPGLNPALTLPRPNEFVSTNFKV 546
V ++S+S E TD E+WYGT YK P ++IK ++ LN LP NEF+ TNF+
Sbjct: 478 VAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFE- 536
Query: 547 DKIDGIKPLDE-----PVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLPHTHASIINSM 601
I PL++ P L+ +SKLW+K+DD+ +P+ + F P + ++
Sbjct: 537 -----ILPLEKEATPYPALIKDTVMSKLWFKQDDKKKKPKACLNFEFFSPFAYVDPLHCN 591
Query: 602 LSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLIILLTRFLQGVNS 661
++ LY +L D+L + Y A A L T G+ ++ G+N+K ILL + ++ + +
Sbjct: 592 MAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMAT 651
Query: 662 FEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKLQVFEKLTFEQ 721
FE + RFEI+K+ +R L N E P+ Y ++ E +W+ E + + +T +
Sbjct: 652 FEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPR 711
Query: 722 LINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIHN---LQVSNNRLRSYLL 778
L FIP + ++ E L+HGNI + AL + +++ + + H L R R L
Sbjct: 712 LKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQL 771
Query: 779 PKGKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFAQLIHEPCFDTLRTKEQL 838
P F Y+ ++ + N I+ Q D+ S + LF Q+I EPCF+TLRTKEQL
Sbjct: 772 PDRGWFVYQQ--RNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQL 829
Query: 839 GYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVLRDMPEEDFEKHKEAL 898
GY+VFS +G ++R +IQSE YLE R+ F T + + DM EE F+KH +AL
Sbjct: 830 GYIVFSGPRRANGIQSLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQAL 889
Query: 899 CNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMIDFYENYIM--SE 956
L K K ++ E A+Y I YNF + + +TK+ +I FY+ + +
Sbjct: 890 AIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAP 949
Query: 957 NASKLILHLKSQ------VENKELNENELDTAK---YPTGQLIEDVGAFKSTLFVAPVRQ 1007
K+ +H+ ++ V + +N+++ ++ P ++I+++ FK L + P+ +
Sbjct: 950 RRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVK 1009
Query: 1008 PMKDF 1012
P +F
Sbjct: 1010 PHINF 1014
>ref|XP_001603463.1| PREDICTED: similar to metalloprotease [Nasonia vitripennis]
Length = 999
Score = 679 bits (1753), Expect = 0.0, Method: Composition-based stats.
Identities = 377/972 (38%), Positives = 570/972 (58%), Gaps = 31/972 (3%)
Query: 63 DFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNLPGLAHFCEH 122
+ +K D+R YR + L NKLK LLI DP DK+AASLDVN+G DPK LPGLAHFCEH
Sbjct: 24 NIVKSPNDKRDYRGLILHNKLKVLLISDPMTDKSAASLDVNVGYLSDPKELPGLAHFCEH 83
Query: 123 LLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGALDRFSGFFSCP 182
+LF+G+ K+P+ N+Y+ YLS++GG+SNA T +TNY+F+VN L GALDRFS FF P
Sbjct: 84 MLFLGTTKYPEVNDYNQYLSQNGGASNAATYLDHTNYYFDVNPDKLEGALDRFSQFFVSP 143
Query: 183 LFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGTLPKE 242
LF + +T+KEI AV+ E++KN+ ND WR+ QLDKS + H Y KF TG+ +TL +PK+
Sbjct: 144 LFTESATEKEITAVHLEHEKNIANDTWRMDQLDKSSADPSHAYSKFGTGSKDTLEVIPKQ 203
Query: 243 NGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGREVPLYAEPI 302
++VR ELL FH +YSAN+M L +LG+E LD L D+F D+ N EVP +
Sbjct: 204 KNIDVRQELLNFHNTWYSANIMALSVLGKESLDDLEKMIVDMFSDIDNKNVEVPKWPAHP 263
Query: 303 MQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGSGSLLAHLKK 362
EH + + P+KD++ L I+F +PDM+EH+ + P SHL+GHEG GSLL+ LK+
Sbjct: 264 FTDEHFKTKWFIVPIKDIRNLNITFPIPDMQEHFRAAPVHYWSHLLGHEGKGSLLSTLKE 323
Query: 363 LGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLPQKWIFN 422
GW N L +G + ++G FF+V +DLT+ G+ H D++ + FQYI MLKN P +WIF
Sbjct: 324 KGWCNSLVSGKRSSARGFDFFSVYVDLTEEGILHVDDIVTMTFQYINMLKNEGPVEWIFE 383
Query: 423 ELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRIL-AMGLLTKYEPDLLTQYTDA 481
E DI+ F+FK+ SP S V+ + L+ DY P+ +L A L T++ PDL+ + +
Sbjct: 384 EYSDIAKMNFRFKEKASPRSYVNVTVQSLQ-DY-PIEEVLSASRLFTQWRPDLINELNNY 441
Query: 482 LVPENSRVTLISRSLE--TDSAEKWYGTAYKVVDYPADLIKNMKSPGLNPALTLPRPNEF 539
LVPE RV +++++ E DS E WYGT YK P DLI+ + G + A LP NEF
Sbjct: 442 LVPEKIRVQVVAKAYEANADSVEPWYGTKYKKEKIPEDLIQRWNNAGTDEAFQLPEKNEF 501
Query: 540 VSTNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLPHTHASIIN 599
+ T F + I+ + P ++ + + W+K+DD F P+ + F P T+ I+
Sbjct: 502 IPTKFDIKSIEKAEKF--PTIIEDNPFIRTWFKQDDEFLLPKATMTFDFVSPLTYIDPIS 559
Query: 600 SMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLIILLTRFLQGV 659
S ++ ++ QL D+L + Y A A L+ + + GL++ +G++ KL++LL + L +
Sbjct: 560 SNMTYMFVQLFRDSLNEYAYSADLAGLKWELSHSKYGLSLIIAGYDHKLVVLLNKILDRM 619
Query: 660 NSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKLQVFEKLTF 719
+F RF ILK+ IR LKN E PY + Y A+++E+ W E L LT
Sbjct: 620 VNFTIDDKRFAILKENYIRGLKNFEAEQPYQHAAYYLAALMSEQVWVKNELLNACSMLTA 679
Query: 720 EQLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIHNLQVSNNR----LRS 775
+++ FIP + ++ E LIHGNI EAL+ ++S + +++ +L + R
Sbjct: 680 DRVRQFIPLLMSKMHIECLIHGNITKAEALKTVKNVESKLISSVKDLTPLLPKQLVLYRE 739
Query: 776 YLLPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFAQLIHEPCFDTLRTK 835
LP G + YE + + + +SC Q Q + S + + L LF Q+I EPCF+ LRTK
Sbjct: 740 LELPNGCHYLYE--VDNKHHKSSCTQIYYQSGMQSTESNMLLELFTQIISEPCFNILRTK 797
Query: 836 EQLGYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVLRDMPEEDFEKHK 895
EQLGY+VFS +G +RI++QS ++E RI+ F E+ + +M +E+F +HK
Sbjct: 798 EQLGYIVFSGIRRTNGVQGLRIIVQSNKHPQFVEERIDAFMESMKDYITNMSDEEFNRHK 857
Query: 896 EALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMIDFYENYIMS 955
E+L L+K K + +S Y I + YNF + + I++ Q+IDFY++ + S
Sbjct: 858 ESLATQRLEKPKMLTSQSGIYWNEISMQQYNFDRANVEVAYLKTISRSQIIDFYKDVVHS 917
Query: 956 ENAS--KLILHLKSQVENKELNENELDTAKYPTGQ--------------LIEDVGAFKST 999
E+ KL +H+ S E E+ T+ P+ + I+D+ FK++
Sbjct: 918 ESPQRHKLSIHVVSTAEGGAAAEDV--TSSTPSAEETKKTLEQAEQQPARIQDILQFKTS 975
Query: 1000 LFVAPVRQPMKD 1011
+ P+ +P +
Sbjct: 976 HPLYPLVKPFNN 987
>ref|XP_971897.1| PREDICTED: similar to Insulin-degrading enzyme (Insulysin)
(Insulinase) (Insulin protease) [Tribolium castaneum]
Length = 977
Score = 679 bits (1753), Expect = 0.0, Method: Composition-based stats.
Identities = 365/956 (38%), Positives = 565/956 (59%), Gaps = 15/956 (1%)
Query: 63 DFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNLPGLAHFCEH 122
+ +K D+R YR +EL N +K LL+ DP DK+AA++DVN+G DP+++ GLAHFCEH
Sbjct: 14 NIIKSQEDKRLYRGLELANHMKVLLVSDPTTDKSAAAMDVNVGFMSDPRDVYGLAHFCEH 73
Query: 123 LLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGALDRFSGFFSCP 182
+LF+G++K+P+EN+Y+ YLS+HGGSSNA T +T Y+F++ L ALDRFS FF P
Sbjct: 74 MLFLGTKKYPNENDYNKYLSEHGGSSNAATYPDHTIYYFDIVPDELNNALDRFSQFFIAP 133
Query: 183 LFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGTLPKE 242
LF + +TD+E+NAVNSE++KN+ ND+WR QLDK L + KHPYH F TGN TL TLPKE
Sbjct: 134 LFTESATDREMNAVNSEHEKNIPNDVWRKDQLDKHLADPKHPYHTFGTGNRHTLDTLPKE 193
Query: 243 NGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGREVPLYAEPI 302
+NVRDELLKFH +YS+N+M L +LG+E LD L LF +V + P + E
Sbjct: 194 KNINVRDELLKFHDKWYSSNIMCLAVLGKESLDDLEQMVVKLFSEVKDKAIAAPRWEEHP 253
Query: 303 MQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGSGSLLAHLKK 362
+ EH + + P+KD++ L I F D++E+++S P +SHL+GHEG GS+L+ LK
Sbjct: 254 FKDEHFGTCVYMYPIKDVRNLNIVFPCRDLQEYYKSSPSHYISHLMGHEGPGSILSTLKA 313
Query: 363 LGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLPQKWIFN 422
GW+N L AG +G FF V +DLT+ G+ H D++ LIFQY+ MLK PQKW+ +
Sbjct: 314 RGWSNNLVAGSRPAPRGLGFFGVTVDLTEEGIKHIDDIVELIFQYLNMLKRQGPQKWVQD 373
Query: 423 ELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILAMGLLTKYEPDLLTQYTDAL 482
E +DI N F+FK SP S ++ L L+ DY + M L +++ PD++ Q +
Sbjct: 374 ENRDIGNMLFRFKDKESPRSYIAGLVHTLQ-DYSMEDVLSCMYLFSEWRPDIIEQVWNDF 432
Query: 483 VPENSRVTLISRSLET--DSAEKWYGTAYKVVDYPADLIKNMKSPGLNPALTLPRPNEFV 540
VPE R+ ++++ E D E WYGT YKV P ++ + L+ LP NEF+
Sbjct: 433 VPEKIRIVVLAKQYENELDQVEPWYGTKYKVAKIPEKTLERWRKSELSGDFKLPEKNEFI 492
Query: 541 STNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLPHTHASIINS 600
T+F++ ID + + PV++ ++++W+K+D+ F P+ + F P + +N
Sbjct: 493 PTDFELYPIDK-EVTEHPVIIQDTALTRVWFKQDETFLLPKANVMFDFVSPLAYLDPLNC 551
Query: 601 MLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLIILLTRFLQGVN 660
L+ + QL DAL + Y A A L+ T GL + G++ K I L + ++ +
Sbjct: 552 NLTHMLVQLFRDALNEYAYAAELAGLKWELINTKYGLILAIGGYSNKQHIFLDKVMEKLT 611
Query: 661 SFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKLQVFEKLTFE 720
+F+ RFEI K+ IR+LKN E PY Y A++ E SW+ E L E+LT +
Sbjct: 612 NFKIDPKRFEICKENYIRNLKNFAAEQPYQHAVYYLAALLTEHSWTKQELLATTEQLTID 671
Query: 721 QLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIHNLQVSNNRL---RSYL 777
+L FIP I ++ E LIHGN E+AL++ +++ + + ++ + +L R
Sbjct: 672 KLEAFIPQILSKMHIECLIHGNANKEKALQLVQIVEDRLLSTLNMSPLLPRQLLLNRELK 731
Query: 778 LPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFAQLIHEPCFDTLRTKEQ 837
L G + YE +++ + SCI+ Q + S++ + LFAQ++ EPCFD LRTKEQ
Sbjct: 732 LEDGCNYVYE--VQNEVHKESCIELYYQCGLQSKENNMKLELFAQIVQEPCFDILRTKEQ 789
Query: 838 LGYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVLRDMPEEDFEKHKEA 897
LGY+VFS ++G +RI++QS+ L+ RI F + L++M EE+F +H+EA
Sbjct: 790 LGYIVFSGIRRSNGVQGLRIIVQSDKHPVRLDERIEEFLKNMLSYLKNMSEEEFARHREA 849
Query: 898 LCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMIDFYENYIMSEN 957
L L+K K ++ ++ + I Y+F + + +TK+ +IDFY++ ++ EN
Sbjct: 850 LAAQRLEKPKQLSTQTNIFWGEITSQQYHFDRANVEVAYLRTLTKEDIIDFYKS-LLEEN 908
Query: 958 AS---KLILHLKSQVEN--KELNENELDTAKYPTGQLIEDVGAFKSTLFVAPVRQP 1008
A KL +H+ S + ++ ++ + G ++ D+ FKS+ + P+ QP
Sbjct: 909 AQFRKKLSVHVVSMADGGAGKMAASDKEYTVDSKGTVVCDITVFKSSHEMHPLVQP 964
>ref|XP_001731164.1| hypothetical protein MGL_1347 [Malassezia globosa CBS 7966]
gb|EDP43950.1| hypothetical protein MGL_1347 [Malassezia globosa CBS 7966]
Length = 1110
Score = 678 bits (1750), Expect = 0.0, Method: Composition-based stats.
Identities = 368/959 (38%), Positives = 569/959 (59%), Gaps = 31/959 (3%)
Query: 57 FKTFNLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNLPGL 116
++ F KP +D+R Y+ I L N L+ALLI DP+ADKA+A++DV +G DP+ L G+
Sbjct: 36 YEAFEGSMEKPLIDKREYKLIRLENGLEALLIHDPEADKASAAMDVRVGHLSDPEGLYGM 95
Query: 117 AHFCEHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGALDRFS 176
AHFCEHLLFMG++K+P ENEYS YLS H GSSNA+T+ +NTNYFF+V + H GALDRF+
Sbjct: 96 AHFCEHLLFMGTKKYPRENEYSEYLSNHSGSSNAFTSLENTNYFFDVGYAHFEGALDRFA 155
Query: 177 GFFSCPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETL 236
FF PLF+ +++EI AV+SE+KKNLQ+D+WR +QLDK+L+N HPY KF TGN+ TL
Sbjct: 156 QFFLEPLFDPSCSEREIRAVDSEHKKNLQSDLWRSFQLDKTLSNPSHPYSKFGTGNLATL 215
Query: 237 GTLPKENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGREVP 296
P+E GL++RDELLKFH+ +YSAN+MKL +LGRE L++W + F +V N +VP
Sbjct: 216 WEKPREMGLDIRDELLKFHERYYSANMMKLVVLGRESTAKLTEWVAEKFSNVPNKQCDVP 275
Query: 297 LYAEPIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGSGSL 356
+ + L + R +KD++ L+I+F P+ + + SKP ++LSHLIGHEG GSL
Sbjct: 276 SFPGSPLSDRELGTQVLFRTIKDVRLLDITFPFPEQADLYRSKPGQLLSHLIGHEGHGSL 335
Query: 357 LAHLKKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLP 416
+ LK+ GWAN LSAG +KG F ++IDLT G HY DV+ +FQYI+ML+
Sbjct: 336 FSCLKQRGWANLLSAGSAIHAKGFELFKINIDLTHEGYEHYGDVVAAVFQYIDMLRAKPI 395
Query: 417 QKWIFNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILAMGLLTKYEPDLLT 476
++W++ E+Q +S F FK+ SP+ S+LA ++ P + +L +++ L++
Sbjct: 396 EQWLYEEVQRLSELRFIFKEKSSPAMYSSTLASQMQHSLPPEWLLSGPYVLREFDAPLIS 455
Query: 477 QYTDALVPENSRVTLISRS----LETDSAEKWYGTAYKVVDYPADLIKNMKSPGLNPALT 532
+ L P+ R+ L R + D +E WYGT Y + + +++ + ++ L+
Sbjct: 456 STLEYLRPDRCRLMLAGREPPAGVSLDKSETWYGTEYTIKPFVPEMLNSCETL---QGLS 512
Query: 533 LPRPNEFVSTNFKV--DKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKL 590
+PR NEF+ N +V + I P + P LL ++LW+K+DDRF+ P+ + + +
Sbjct: 513 MPRENEFIPHNLEVLREPNGDIPPSNRPQLLEHTPKARLWHKQDDRFFLPKANVAMLLRT 572
Query: 591 PHTHASIINSMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLII 650
P+ +AS +++LS L +L DAL + YDA A L + G+ I G+N+KL
Sbjct: 573 PYVNASPRHAVLSRLLVELTKDALCEYSYDADVAGLHYDVDSHLDGVDIVVGGYNDKLAH 632
Query: 651 LLTRFLQGVNSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEK 710
LL L + + + RF I+ D+ R+ +N E P+ + Y ++ ER W+ EK
Sbjct: 633 LLESVLNTLTKLQVDEKRFAIVHDQVRRNYENFDLEEPFQHAAYYSTYLVTERMWTQHEK 692
Query: 711 LQVFEKLTFEQLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIHNLQVS- 769
L+V +T + + +I +++ ++ E L+HGN+ ++A + L+ +LQ
Sbjct: 693 LRVVNDVTAQDVQKYISELFQQMHVEMLVHGNLTRDDA-------RRLLETAQRHLQYEA 745
Query: 770 -----NNRLRSYLLPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSE-DLSALSGLFAQL 823
RS +L G + + + NVNS +++ Q+ SE L A L AQ+
Sbjct: 746 LDTHHTTPPRSLVLSPGSRVSWRVPVANKSNVNSSLEYYCQVGDPSEVRLRATLALLAQI 805
Query: 824 IHEPCFDTLRTKEQLGYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVL 883
EPCFD LRTKEQLGY+VFS + G R+++QSE + YLE RI+ F++ L
Sbjct: 806 ASEPCFDQLRTKEQLGYLVFSGVRTSIGQMGFRVIVQSERDSDYLESRIDAFFDQLLHQL 865
Query: 884 RDMPEEDFEKHKEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQ 943
+M ++F H+ +L + L+ KN+AEE+ RY +I+ G Y+F +RQ+ A+++ ++TK
Sbjct: 866 HEMSTDEFLAHRNSLIHKRLESVKNLAEETNRYWQSIHSGYYDFMNRQRDAQVLEHLTKN 925
Query: 944 QMIDFYENYI--MSENASKLILHLKSQVENKELNENELDTAKYPTGQLIEDVGAFKSTL 1000
+I E+YI S +K + HL++ L +E +TA+ T E + AF L
Sbjct: 926 DVIALMEHYIHPSSPRRAKTVTHLQA------LPGDEANTAQSTTPLSKEALDAFLHVL 978
>ref|XP_001590112.1| hypothetical protein SS1G_08876 [Sclerotinia sclerotiorum 1980]
gb|EDN93011.1| hypothetical protein SS1G_08876 [Sclerotinia sclerotiorum 1980]
Length = 1030
Score = 673 bits (1736), Expect = 0.0, Method: Composition-based stats.
Identities = 396/996 (39%), Positives = 573/996 (57%), Gaps = 66/996 (6%)
Query: 67 PDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNLPGLAHFCEHLLFM 126
P LD+RSYR I+LPN+L+ LL+ D + DKA+A++DVN+G F DP++ PG+AH E
Sbjct: 37 PSLDDRSYRVIKLPNQLEVLLVHDAETDKASAAMDVNVGNFSDPEDFPGMAHAVE----- 91
Query: 127 GSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEV-------------NHQHLFGALD 173
+P EN YS YLS H GSSNAYT + +TNY+FEV N L+GALD
Sbjct: 92 ----YPVENAYSQYLSSHSGSSNAYTGATSTNYYFEVAAKSGEDGASGDSNLSPLYGALD 147
Query: 174 RFSGFFSCPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNI 233
RF+ FF PLF + D+E+ AV+SENKKNLQ+D WR++QLDKSL+N KHPY FSTGN+
Sbjct: 148 RFAQFFIDPLFLDSTLDRELKAVDSENKKNLQSDQWRLHQLDKSLSNPKHPYCHFSTGNL 207
Query: 234 ETLGTLPKENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGR 293
E L P+ G+NVR++ ++FH+ YSAN MKL ILGRE LD L W DLF V N +
Sbjct: 208 EVLKIQPESRGINVREKFMEFHEKHYSANRMKLVILGREPLDKLESWAADLFAGVRN--K 265
Query: 294 EVP---LYAEPIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGH 350
++P E PE L +PV D + L+IS D E +ES+P R L+HLIGH
Sbjct: 266 DLPQNRWEDERPYGPEQLSTQCFAKPVMDSRTLDISIPFIDEELLFESQPSRYLTHLIGH 325
Query: 351 EGSGSLLAHLKKLGWANELSAGGHTVSKGN-AFFAVDIDLTDNGLTHYRDVIVLIFQYIE 409
EG GS++A++K GWAN LSAG + + G F+ I LT++GL +Y++V+ + FQYI
Sbjct: 326 EGPGSIMAYIKSKGWANALSAGVYPICPGTPGLFSCQIRLTEDGLKNYKEVVKVFFQYIA 385
Query: 410 MLKNSLPQKWIFNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILA-MGLLT 468
+LK++ PQ+WIFNE + +++ FKFKQ +P+S +S + + +P +L+ L
Sbjct: 386 LLKDAPPQEWIFNEQKGLADVDFKFKQK-TPASRFTSKISAVMQTPLPREWLLSGHSRLR 444
Query: 469 KYEPDLLTQYTDALVPENSRVTLISRSLET--DSAEKWYGTAYKVVDYPADLIKNMKSPG 526
K++ ++ D L +N R+ + S++ DS EKWYGT YK PAD ++ +K
Sbjct: 445 KFDAGKISAGLDCLRADNFRMQISSQTFPGGWDSKEKWYGTEYKYEKIPADFLEEIKKAA 504
Query: 527 LN------PALTLPRPNEFVSTNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQP 580
+ P L LP N+F+ T +V+K + P P L+ +DD + W+KKDD FW P
Sbjct: 505 SSKKGERFPELHLPHVNQFIPTKLEVEKKEVQTPAISPKLIRNDDAVRTWFKKDDTFWVP 564
Query: 581 RGYIYLSFKLPHTHASIINSMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAIT 640
+ +++ + P A+ NS+ + +YT L DAL+D YDA A L S + + GL I+
Sbjct: 565 KANLFIQCRNPLPMATAENSLKARMYTDLVYDALEDYAYDAELAGLEYSVSSHSMGLEIS 624
Query: 641 ASGFNEKLIILLTRFLQGVNSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAII 700
SG+N+KL +LL + L + E K+DRFEI+K++ R LKN ++ PY+Q+ +Y +
Sbjct: 625 VSGYNDKLSVLLEKVLTTMRDLEIKQDRFEIIKERLTRGLKNWDFQQPYNQVGDYMRWLS 684
Query: 701 NERSWSTAEKLQVFEKLTFEQLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLI- 759
+E+ + + L LT + F P + ++ ET +HGN+ E+AL++ L +S++
Sbjct: 685 SEKGYINEQYLAELPHLTAADIQQFYPHLLRQMHIETFVHGNLYKEDALKLADLTESILK 744
Query: 760 PNNIHNLQVSNNRLRSYLLPKGKTFRYETALKDSQNVNSCIQHVTQL-DVYSEDLSALSG 818
P + Q RS + P G F Y LKD NVN CI++V + D A +
Sbjct: 745 PRVLPQTQWPIG--RSLVFPPGANFVYHKTLKDPANVNHCIEYVLSIGDKAIRPQRAKTL 802
Query: 819 LFAQLIHEPCFDTLRTKEQLGYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYET 878
L Q+ HEP FD LRTKEQLGYVVFS T R +IQSE T YLE RI++F
Sbjct: 803 LLDQMTHEPAFDQLRTKEQLGYVVFSGCSTTTTTIAYRFIIQSEKTPQYLEERIDSFLVG 862
Query: 879 FGQVLRDMPEEDFEKHKEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVA 938
+ ++L++M + +FE HK +L L+K KN+ +ES R + I ++F A V
Sbjct: 863 YSEILKNMSDSEFEGHKRSLITKRLEKLKNLDQESNRIWSHIDYEYFDFELVHHDAANVK 922
Query: 939 NITKQQMIDFYENYIMSENA--SKLILHLKSQ------------------VENKELNENE 978
+TK+ MI FY+ +I+ + SKL +HL +Q + K+ + E
Sbjct: 923 ALTKEDMIQFYDQFILPSSPLRSKLAIHLIAQGTSLPEEKPEEQSVLAINKDRKDAEDGE 982
Query: 979 LDTAKYPTG----QLIEDVGAFKSTLFVAPVRQPMK 1010
K +I DV FKS L V QP+K
Sbjct: 983 AIVVKVEGNGTKPYVITDVRQFKSMLQVTAGPQPVK 1018
>ref|XP_534963.2| PREDICTED: similar to Insulin-degrading enzyme (Insulysin)
(Insulinase) (Insulin protease) [Canis familiaris]
Length = 994
Score = 672 bits (1734), Expect = 0.0, Method: Composition-based stats.
Identities = 363/965 (37%), Positives = 564/965 (58%), Gaps = 47/965 (4%)
Query: 65 LKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNLPGLAHFCEHLL 124
+K D+R YR +EL N +K LLI DP DK++A+LDV+IG+ DP N+ GL+HFCEH+L
Sbjct: 55 IKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHML 114
Query: 125 FMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGALDRFSGFFSCPLF 184
F+G++K+P ENEYS +LS+H GSSNA+T+ ++TNY+F+V+H+HL GALDRF+ FF CPLF
Sbjct: 115 FLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLF 174
Query: 185 NKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGTLPKENG 244
++ D+E+NAV+SE++KN+ ND WR++QL+K+ N KHP+ KF TGN TL T P + G
Sbjct: 175 DESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEG 234
Query: 245 LNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGREVPLYAEPIMQ 304
++VR ELLKFH +YS+NLM +C+LGRE LD L++ LF +V N +P + E Q
Sbjct: 235 IDVRQELLKFHSTYYSSNLMAICVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQ 294
Query: 305 PEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGSGSLLAHLKKLG 364
EHL+++ ++ P+KD++ L ++F +PD++++++S P L HLIGHEG GSLL+ LK G
Sbjct: 295 EEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKG 354
Query: 365 WANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLPQKWIFNEL 424
W N L G ++G FF +++DLT+ GL H D+I+ +FQYI+ L+ PQ+W+F E
Sbjct: 355 WVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQEC 414
Query: 425 QDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRIL-AMGLLTKYEPDLLTQYTDALV 483
+D++ F+FK P S +A L Y P+ +L A LL ++ PDL+ D L
Sbjct: 415 KDLNAVAFRFKDKERPRGYTSKIAGILH--YYPLEEVLTAEYLLEEFRPDLIEMVLDKLR 472
Query: 484 PENSRVTLISRSLE--TDSAEKWYGTAYKVVDYPADLIKNMKSPGLNPALTLPRPNEFVS 541
PEN RV ++S+S E TD E+WYGT YK P ++IK L+L +
Sbjct: 473 PENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAVPDEVIK---------ILSLEKEAH--- 520
Query: 542 TNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLPHTHASIINSM 601
P L+ +SKLW+K+DD+F+ P+ + F P + ++
Sbjct: 521 --------------PYPSLIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCN 566
Query: 602 LSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLIILLTRFLQGVNS 661
++ LY +L D+L + Y A A L T G+ ++ G+N+K ILL + ++ + +
Sbjct: 567 MAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMAT 626
Query: 662 FEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKLQVFEKLTFEQ 721
FE + RFEI+K+ +R L N E P+ Y ++ E +W+ E + + +T +
Sbjct: 627 FEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPR 686
Query: 722 LINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIHN---LQVSNNRLRSYLL 778
L FIP + ++ E L+HGNI + AL + +++ + + H L R R L
Sbjct: 687 LKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQL 746
Query: 779 PKGKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFAQLIHEPCFDTLRTKEQL 838
P F Y+ ++ + N I+ Q D+ S + LF Q+I EPCF+TLRTKEQL
Sbjct: 747 PDRGWFVYQQ--RNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQL 804
Query: 839 GYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVLRDMPEEDFEKHKEAL 898
GY+VFS +G +R +IQSE YLE R+ F T + + DM EE F+KH +AL
Sbjct: 805 GYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQAL 864
Query: 899 CNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMIDFYENYIM--SE 956
L K K ++ E A+Y I YNF + + +TK+ +I FY+ + +
Sbjct: 865 AIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAP 924
Query: 957 NASKLILHLKSQ------VENKELNENELDTAK---YPTGQLIEDVGAFKSTLFVAPVRQ 1007
K+ +H+ ++ V + +N+++ ++ P ++I+++ FK L + P+ +
Sbjct: 925 RRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVK 984
Query: 1008 PMKDF 1012
P +F
Sbjct: 985 PHINF 989
Searching..................................................done
Results from round 2
Score E
Sequences producing significant alignments: (bits) Value
Sequences used in model and found again:
ref|NP_013493.2| Metalloprotease involved, with homolog Axl... 1375 0.0
gb|EDN59292.1| metalloprotease [Saccharomyces cerevisiae YJ... 1374 0.0
ref|XP_001501085.1| PREDICTED: similar to insulin-degrading... 1168 0.0
ref|XP_001506502.1| PREDICTED: similar to insulin-degrading... 1166 0.0
ref|XP_001646584.1| hypothetical protein Kpol_1055p83 [Vand... 1147 0.0
ref|NP_004960.2| insulysin [Homo sapiens] >gi|55959215|emb|... 1137 0.0
ref|XP_001090249.1| PREDICTED: insulysin isoform 3 [Macaca ... 1136 0.0
ref|XP_507922.2| PREDICTED: insulysin isoform 4 [Pan troglo... 1136 0.0
ref|XP_001276340.1| a-pheromone processing metallopeptidase... 1132 0.0
ref|XP_001146520.1| PREDICTED: insulysin isoform 2 [Pan tro... 1132 0.0
pdb|2G47|A Chain A, Crystal Structure Of Human Insulin-Degr... 1131 0.0
ref|NP_112419.2| insulin degrading enzyme [Mus musculus] >g... 1131 0.0
ref|XP_001090137.1| PREDICTED: insulysin isoform 2 [Macaca ... 1131 0.0
pdb|2JG4|A Chain A, Substrate-Free Ide Structure In Its Clo... 1131 0.0
ref|NP_001069317.1| insulin-degrading enzyme [Bos taurus] >... 1131 0.0
ref|NP_037291.1| insulin degrading enzyme [Rattus norvegicu... 1127 0.0
sp|Q9JHR7|IDE_MOUSE Insulin-degrading enzyme (Insulysin) (I... 1123 0.0
gb|EDL41785.1| insulin degrading enzyme [Mus musculus] 1123 0.0
ref|XP_001146582.1| PREDICTED: insulysin isoform 3 [Pan tro... 1121 0.0
dbj|BAF62161.1| insulin-degrading enzyme [Danio rerio] 1121 0.0
ref|NP_001082994.1| insulin-degrading enzyme [Danio rerio] ... 1121 0.0
ref|NP_984913.1| AER053Cp [Ashbya gossypii ATCC 10895] >gi|... 1119 0.0
pdb|2WBY|A Chain A, Crystal Structure Of Human Insulin-Degr... 1118 0.0
ref|XP_447076.1| unnamed protein product [Candida glabrata]... 1114 0.0
sp|P14735|IDE_HUMAN Insulin-degrading enzyme (Insulysin) (I... 1109 0.0
ref|XP_001266332.1| a-pheromone processing metallopeptidase... 1099 0.0
ref|XP_454175.1| unnamed protein product [Kluyveromyces lac... 1097 0.0
ref|XP_001847597.1| metalloprotease [Culex pipiens quinquef... 1096 0.0
ref|XP_748141.1| a-pheromone processing metallopeptidase St... 1094 0.0
gb|EDP51051.1| a-pheromone processing metallopeptidase Ste2... 1092 0.0
ref|XP_534963.2| PREDICTED: similar to Insulin-degrading en... 1086 0.0
ref|XP_681313.1| hypothetical protein AN8044.2 [Aspergillus... 1082 0.0
ref|XP_001661876.1| metalloprotease [Aedes aegypti] >gi|108... 1082 0.0
ref|XP_001397499.1| hypothetical protein An16g01860 [Asperg... 1082 0.0
ref|XP_505854.1| hypothetical protein [Yarrowia lipolytica]... 1080 0.0
dbj|BAE98754.1| putative zinc protease [Arabidopsis thaliana] 1079 0.0
ref|XP_971897.1| PREDICTED: similar to Insulin-degrading en... 1078 0.0
ref|NP_181710.1| peptidase M16 family protein / insulinase ... 1078 0.0
emb|CAO23586.1| unnamed protein product [Vitis vinifera] 1070 0.0
ref|XP_001242515.1| hypothetical protein CIMG_06411 [Coccid... 1062 0.0
ref|XP_759404.1| hypothetical protein UM03257.1 [Ustilago m... 1060 0.0
ref|XP_001820380.1| hypothetical protein [Aspergillus oryza... 1060 0.0
gb|ABH09708.1| STE23-like protein [Penicillium marneffei] 1058 0.0
gb|AAO74689.1| RE17458p [Drosophila melanogaster] 1055 0.0
ref|XP_001603463.1| PREDICTED: similar to metalloprotease [... 1055 0.0
ref|NP_524182.2| Insulin degrading metalloproteinase CG5517... 1055 0.0
gb|EEH46323.1| insulin-degrading enzyme [Paracoccidioides b... 1054 0.0
ref|NP_001060044.1| Os07g0570300 [Oryza sativa (japonica cu... 1052 0.0
sp|P22817|IDE_DROME Insulin-degrading enzyme (Insulysin) (I... 1050 0.0
gb|EDU43925.1| insulin-degrading enzyme [Pyrenophora tritic... 1050 0.0
ref|XP_956166.1| hypothetical protein NCU00481 [Neurospora ... 1047 0.0
gb|AAA28439.1| insulin-degrading enzyme 1047 0.0
emb|CAO23585.1| unnamed protein product [Vitis vinifera] 1046 0.0
ref|XP_001543275.1| conserved hypothetical protein [Ajellom... 1042 0.0
gb|EEH33611.1| A-factor-processing enzyme [Paracoccidioides... 1041 0.0
ref|XP_001770543.1| predicted protein [Physcomitrella paten... 1035 0.0
ref|XP_001801272.1| hypothetical protein SNOG_11020 [Phaeos... 1033 0.0
emb|CAC67408.1| insulin degrading enzyme [Solanum lycopersi... 1030 0.0
ref|XP_387087.1| hypothetical protein FG06911.1 [Gibberella... 1028 0.0
dbj|BAC79699.1| putative insulin degrading enzyme [Oryza sa... 1027 0.0
ref|XP_001908020.1| unnamed protein product [Podospora anse... 1025 0.0
ref|XP_001354132.1| GA18943-PA [Drosophila pseudoobscura] >... 1025 0.0
ref|XP_360292.2| hypothetical protein MGG_13149 [Magnaporth... 1024 0.0
ref|XP_001218442.1| hypothetical protein ATEG_09820 [Asperg... 1022 0.0
ref|XP_001590112.1| hypothetical protein SS1G_08876 [Sclero... 1021 0.0
ref|XP_001629798.1| predicted protein [Nematostella vectens... 1021 0.0
ref|XP_311589.4| AGAP010351-PA [Anopheles gambiae str. PEST... 1020 0.0
gb|EAZ04397.1| hypothetical protein OsI_025629 [Oryza sativ... 1020 0.0
ref|NP_001044429.1| Os01g0778800 [Oryza sativa (japonica cu... 1019 0.0
gb|EAZ40359.1| hypothetical protein OsJ_023842 [Oryza sativ... 1019 0.0
ref|ZP_01258854.1| peptidase, insulinase family protein [Vi... 1014 0.0
ref|NP_798585.1| peptidase, insulinase family [Vibrio parah... 1014 0.0
ref|ZP_02195786.1| peptidase, insulinase family protein [Vi... 1012 0.0
ref|XP_001761886.1| predicted protein [Physcomitrella paten... 1011 0.0
emb|CAB66104.1| protease-like protein [Arabidopsis thaliana] 1010 0.0
ref|XP_001731164.1| hypothetical protein MGL_1347 [Malassez... 1008 0.0
ref|ZP_01474320.1| hypothetical protein VEx2w_02003082 [Vib... 1003 0.0
ref|NP_741542.1| F44E7.4b [Caenorhabditis elegans] >gi|2128... 1002 0.0
ref|ZP_01987074.1| insulin-degrading enzyme [Vibrio harveyi... 1002 0.0
gb|EDN12518.1| peptidase, insulinase family [Vibrio cholera... 997 0.0
ref|ZP_01948940.1| peptidase, insulinase family [Vibrio cho... 996 0.0
ref|ZP_01978745.1| peptidase, insulinase family [Vibrio cho... 996 0.0
ref|ZP_01482660.1| hypothetical protein VchoR_02001413 [Vib... 995 0.0
ref|ZP_01956551.1| peptidase, insulinase family [Vibrio cho... 995 0.0
gb|EDN15048.1| peptidase, insulinase family [Vibrio cholera... 995 0.0
ref|NP_231704.1| peptidase, insulinase family [Vibrio chole... 994 0.0
ref|XP_001391726.1| hypothetical protein An07g06490 [Asperg... 994 0.0
ref|NP_741543.1| F44E7.4a [Caenorhabditis elegans] >gi|2291... 994 0.0
ref|NP_935232.1| peptidase, insulinase family [Vibrio vulni... 993 0.0
ref|ZP_01981574.1| peptidase, insulinase family [Vibrio cho... 993 0.0
ref|ZP_01478796.1| hypothetical protein VchoM_02002058 [Vib... 993 0.0
gb|EAZ49727.1| peptidase, insulinase family [Vibrio cholera... 992 0.0
ref|NP_760850.1| Peptidase [Vibrio vulnificus CMCP6] >gi|27... 992 0.0
gb|EAZ04398.1| hypothetical protein OsI_025630 [Oryza sativ... 992 0.0
ref|ZP_01485575.1| hypothetical protein VchoV5_02001802 [Vi... 990 0.0
ref|YP_129176.1| putative peptidase, insulinase family [Pho... 989 0.0
ref|ZP_01222787.1| putative peptidase, insulinase family pr... 987 0.0
ref|ZP_01813161.1| peptidase, insulinase family protein [Vi... 982 0.0
ref|ZP_01706404.1| peptidase M16-like [Shewanella putrefaci... 980 0.0
ref|YP_001183975.1| peptidase M16 domain protein [Shewanell... 979 0.0
ref|YP_869105.1| peptidase M16 domain protein [Shewanella s... 979 0.0
ref|YP_962945.1| peptidase M16 domain protein [Shewanella s... 978 0.0
gb|EAY76035.1| hypothetical protein OsI_003882 [Oryza sativ... 978 0.0
ref|YP_733547.1| Insulysin [Shewanella sp. MR-4] >gi|113884... 978 0.0
ref|YP_737533.1| peptidase M16 domain protein [Shewanella s... 978 0.0
ref|YP_001094545.1| peptidase M16 domain protein [Shewanell... 977 0.0
ref|YP_001366970.1| peptidase M16 domain protein [Shewanell... 977 0.0
ref|ZP_01235782.1| putative peptidase, insulinase family pr... 977 0.0
ref|NP_001023928.1| F44E7.4d [Caenorhabditis elegans] >gi|5... 977 0.0
ref|ZP_00990723.1| peptidase, insulinase family [Vibrio spl... 976 0.0
ref|YP_001674877.1| peptidase M16 domain protein [Shewanell... 976 0.0
ref|YP_001555276.1| peptidase M16 domain protein [Shewanell... 975 0.0
ref|YP_001051112.1| peptidase M16 domain protein [Shewanell... 975 0.0
ref|ZP_01159983.1| putative peptidase, insulinase family pr... 975 0.0
ref|NP_718646.1| peptidase, M16 family [Shewanella oneidens... 974 0.0
ref|ZP_01844037.1| peptidase M16 domain protein [Shewanella... 974 0.0
ref|XP_001674236.1| Hypothetical protein CBG09322 [Caenorha... 973 0.0
ref|YP_928038.1| peptidase, M16 family [Shewanella amazonen... 972 0.0
ref|ZP_01064420.1| peptidase, insulinase family protein [Vi... 971 0.0
ref|ZP_01866422.1| peptidase, insulinase family protein [Vi... 971 0.0
ref|XP_001763915.1| predicted protein [Physcomitrella paten... 970 0.0
ref|ZP_02157408.1| peptidase, M16 family protein [Shewanell... 970 0.0
ref|YP_001446294.1| hypothetical protein VIBHAR_03118 [Vibr... 970 0.0
ref|XP_719241.1| a-factor pheromone maturation protease [Ca... 968 0.0
ref|XP_001896776.1| insulin-degrading enzyme [Brugia malayi... 967 0.0
ref|YP_001502447.1| peptidase M16 domain protein [Shewanell... 967 0.0
ref|XP_532578.2| PREDICTED: similar to nardilysin (N-argini... 967 0.0
ref|XP_859649.1| PREDICTED: similar to Nardilysin precursor... 966 0.0
ref|XP_513403.2| PREDICTED: nardilysin (N-arginine dibasic ... 965 0.0
ref|XP_001105075.1| PREDICTED: similar to nardilysin (N-arg... 965 0.0
ref|XP_001140946.1| PREDICTED: nardilysin (N-arginine dibas... 965 0.0
ref|NP_002516.2| nardilysin (N-arginine dibasic convertase)... 964 0.0
sp|O43847|NRDC_HUMAN Nardilysin precursor (N-arginine dibas... 963 0.0
ref|NP_001095132.1| nardilysin (N-arginine dibasic converta... 963 0.0
ref|XP_001491329.1| PREDICTED: similar to nardilysin (N-arg... 962 0.0
ref|XP_001491380.1| PREDICTED: similar to nardilysin (N-arg... 961 0.0
emb|CAA63696.1| NRD2 convertase [Rattus sp.] 961 0.0
ref|NP_037125.1| n-arginine dibasic convertase 1 [Rattus no... 961 0.0
emb|CAM16904.1| nardilysin, N-arginine dibasic convertase, ... 961 0.0
gb|EDL90380.1| nardilysin, N-arginine dibasic convertase 1 ... 961 0.0
ref|NP_666262.2| nardilysin, N-arginine dibasic convertase,... 961 0.0
gb|AAH26832.1| Nardilysin, N-arginine dibasic convertase, N... 961 0.0
sp|Q5R4H6|NRDC_PONPY Nardilysin precursor (N-arginine dibas... 960 0.0
emb|CAA63694.1| NRD2 convertase [Homo sapiens] 959 0.0
emb|CAA63698.1| NRD1 convertase [Homo sapiens] 959 0.0
ref|XP_001524140.1| conserved hypothetical protein [Loddero... 958 0.0
ref|YP_001761387.1| peptidase M16 domain protein [Shewanell... 958 0.0
ref|NP_504514.2| F44E7.4c [Caenorhabditis elegans] >gi|2737... 958 0.0
dbj|BAD52843.1| putative insulin degrading enzyme [Oryza sa... 958 0.0
ref|YP_562541.1| peptidase M16-like protein [Shewanella den... 958 0.0
gb|EAX06804.1| nardilysin (N-arginine dibasic convertase), ... 957 0.0
gb|EAX06805.1| nardilysin (N-arginine dibasic convertase), ... 956 0.0
ref|XP_001251166.1| PREDICTED: similar to NRD1 protein isof... 956 0.0
ref|XP_001251122.1| PREDICTED: similar to NRD1 protein isof... 956 0.0
ref|XP_588554.3| PREDICTED: similar to NRD1 protein isoform... 955 0.0
ref|XP_001251077.1| PREDICTED: similar to NRD1 protein isof... 955 0.0
ref|YP_001473373.1| peptidase M16 domain protein [Shewanell... 955 0.0
ref|YP_205192.1| protease III [Vibrio fischeri ES114] >gi|5... 954 0.0
ref|XP_568105.1| insulin degrading enzyme [Cryptococcus neo... 953 0.0
ref|XP_773498.1| hypothetical protein CNBI1120 [Cryptococcu... 953 0.0
ref|XP_001491299.1| PREDICTED: similar to nardilysin (N-arg... 953 0.0
ref|ZP_02135987.1| insulin-degrading enzyme [Vibrio fischer... 953 0.0
ref|XP_001491355.1| PREDICTED: similar to nardilysin (N-arg... 953 0.0
ref|YP_001141698.1| insulinase [Aeromonas salmonicida subsp... 953 0.0
ref|YP_856528.1| peptidase, insulinase family [Aeromonas hy... 952 0.0
ref|XP_001140731.1| PREDICTED: nardilysin (N-arginine dibas... 951 0.0
ref|NP_593966.1| metallopeptidase [Schizosaccharomyces pomb... 950 0.0
gb|EAX06808.1| nardilysin (N-arginine dibasic convertase), ... 950 0.0
ref|XP_001146439.1| PREDICTED: insulysin isoform 1 [Pan tro... 950 0.0
ref|XP_001090017.1| PREDICTED: insulysin isoform 1 [Macaca ... 949 0.0
gb|AAQ63406.1| nardilysin isoform [Homo sapiens] 948 0.0
ref|NP_507226.2| Y70C5C.1 [Caenorhabditis elegans] >gi|5808... 948 0.0
gb|AAH23786.1| Nrd1 protein [Mus musculus] 947 0.0
gb|EAZ40360.1| hypothetical protein OsJ_023843 [Oryza sativ... 946 0.0
ref|XP_001775609.1| predicted protein [Physcomitrella paten... 942 0.0
ref|YP_751350.1| peptidase M16 domain protein [Shewanella f... 940 0.0
gb|AAC39597.1| NRD convertase [Homo sapiens] 938 0.0
ref|XP_001140801.1| PREDICTED: nardilysin (N-arginine dibas... 937 0.0
ref|NP_001038180.2| hypothetical protein LOC557565 [Danio r... 935 0.0
ref|XP_001383768.2| hypothetical protein PICST_56651 [Pichi... 932 0.0
ref|NP_001118852.1| peptidase M16 family protein / insulina... 930 0.0
ref|XP_001362262.1| PREDICTED: similar to nardilysin (N-arg... 930 0.0
ref|XP_001362352.1| PREDICTED: similar to nardilysin (N-arg... 929 0.0
ref|XP_001760214.1| predicted protein [Physcomitrella paten... 928 0.0
ref|NP_001026455.1| nardilysin (N-arginine dibasic converta... 926 0.0
ref|XP_694205.1| PREDICTED: similar to Nardilysin, N-argini... 922 0.0
ref|XP_456547.1| hypothetical protein DEHA0A05214g [Debaryo... 920 0.0
ref|XP_001486793.1| hypothetical protein PGUG_00170 [Pichia... 919 0.0
ref|YP_436112.1| Secreted/periplasmic Zn-dependent peptidas... 915 0.0
ref|NP_504532.1| C02G6.1 [Caenorhabditis elegans] >gi|12801... 911 0.0
emb|CAO77947.1| nardilysin, N-arginine dibasic convertase, ... 903 0.0
dbj|BAF01167.1| hypothetical protein [Arabidopsis thaliana] 898 0.0
ref|NP_172173.2| metalloendopeptidase [Arabidopsis thaliana] 898 0.0
ref|ZP_00827012.1| COG1025: Secreted/periplasmic Zn-depende... 896 0.0
ref|YP_001007484.1| protease III precursor [Yersinia entero... 894 0.0
ref|XP_001874916.1| predicted protein [Laccaria bicolor S23... 893 0.0
emb|CAO21314.1| unnamed protein product [Vitis vinifera] 893 0.0
gb|EAY76045.1| hypothetical protein OsI_003892 [Oryza sativ... 893 0.0
ref|YP_001480039.1| peptidase M16 domain protein [Serratia ... 892 0.0
ref|ZP_00830096.1| COG1025: Secreted/periplasmic Zn-depende... 892 0.0
ref|ZP_01101893.1| protease III precursor [gamma proteobact... 889 0.0
ref|ZP_00822919.1| COG1025: Secreted/periplasmic Zn-depende... 889 0.0
ref|ZP_00834380.1| COG1025: Secreted/periplasmic Zn-depende... 888 0.0
ref|XP_001833053.1| hypothetical protein CC1G_01115 [Coprin... 886 0.0
ref|YP_001573574.1| hypothetical protein SARI_04665 [Salmon... 884 0.0
ref|ZP_02644586.1| protease III [Salmonella enterica subsp.... 883 0.0
ref|NP_461912.1| protease III [Salmonella typhimurium LT2] ... 882 0.0
ref|ZP_03838288.1| hypothetical protein CATC2_19978 [Citrob... 882 0.0
ref|NP_755290.1| Protease III precursor [Escherichia coli C... 881 0.0
ref|ZP_00713497.1| COG1025: Secreted/periplasmic Zn-depende... 881 0.0
gb|EAY89915.1| hypothetical protein OsI_011148 [Oryza sativ... 881 0.0
ref|YP_311808.1| protease III [Shigella sonnei Ss046] >gi|7... 881 0.0
ref|ZP_00714851.1| COG1025: Secreted/periplasmic Zn-depende... 881 0.0
ref|ZP_02683828.1| protease III [Salmonella enterica subsp.... 881 0.0
ref|ZP_02343890.1| protease III [Salmonella enterica subsp.... 881 0.0
ref|ZP_00923440.1| COG1025: Secreted/periplasmic Zn-depende... 881 0.0
ref|ZP_02999194.1| protease III [Escherichia coli 53638] >g... 881 0.0
ref|NP_001050040.1| Os03g0336300 [Oryza sativa (japonica cu... 881 0.0
ref|YP_001744989.1| protease III [Escherichia coli SMS-3-5]... 880 0.0
ref|ZP_00712570.1| COG1025: Secreted/periplasmic Zn-depende... 880 0.0
ref|NP_708612.1| protease III [Shigella flexneri 2a str. 30... 880 0.0
ref|YP_217920.1| protease III [Salmonella enterica subsp. e... 880 0.0
gb|EAZ26839.1| hypothetical protein OsJ_010322 [Oryza sativ... 880 0.0
ref|YP_001464156.1| protease III [Escherichia coli E24377A]... 880 0.0
ref|ZP_00920643.1| COG1025: Secreted/periplasmic Zn-depende... 880 0.0
ref|NP_417298.1| protease III [Escherichia coli str. K-12 s... 879 0.0
ref|YP_959771.1| peptidase M16 domain protein [Marinobacter... 879 0.0
ref|YP_542202.1| protease III precursor [Escherichia coli U... 879 0.0
ref|ZP_02667694.1| protease III [Salmonella enterica subsp.... 879 0.0
pdb|1Q2L|A Chain A, Crystal Structure Of Pitrilysin 879 0.0
gb|AAB40468.1| protease III precursor (pitrilysin) 879 0.0
ref|ZP_02349797.1| protease III precursor [Salmonella enter... 879 0.0
ref|ZP_02651766.1| protease III precursor [Salmonella enter... 879 0.0
ref|YP_002807041.1| protease III [Escherichia sp. 1_1_43] >... 878 0.0
ref|ZP_02704095.1| protease III [Salmonella enterica subsp.... 878 0.0
ref|NP_311705.1| protease III [Escherichia coli O157:H7 str... 878 0.0
ref|YP_001719796.1| peptidase M16 domain protein [Yersinia ... 878 0.0
ref|ZP_02560586.1| protease III [Salmonella enterica subsp.... 877 0.0
ref|ZP_02832280.1| protease III [Salmonella enterica subsp.... 877 0.0
ref|ZP_02568654.1| protease III [Salmonella enterica subsp.... 877 0.0
ref|YP_001881438.1| protease III [Shigella boydii CDC 3083-... 876 0.0
ref|ZP_03833747.1| protease III precursor [Pectobacterium c... 876 0.0
ref|NP_404633.1| protease III precursor [Yersinia pestis CO... 876 0.0
ref|ZP_02697767.1| protease III [Salmonella enterica subsp.... 876 0.0
ref|YP_409069.1| protease III [Shigella boydii Sb227] >gi|8... 876 0.0
ref|ZP_02900475.1| protease III [Escherichia albertii TW076... 874 0.0
ref|ZP_01896589.1| putative peptidase, insulinase family [M... 874 0.0
ref|YP_404546.1| protease III [Shigella dysenteriae Sd197] ... 874 0.0
ref|NP_289373.1| protease III [Escherichia coli O157:H7 EDL... 874 0.0
ref|YP_001336858.1| protease III [Klebsiella pneumoniae sub... 873 0.0
ref|NP_457388.1| protease III precursor (pitrilysin) [Salmo... 873 0.0
ref|YP_049101.1| protease III precursor [Erwinia carotovora... 872 0.0
ref|ZP_01892098.1| Secreted/periplasmic Zn-dependent peptid... 871 0.0
ref|YP_001177979.1| peptidase M16 domain protein [Enterobac... 869 0.0
ref|YP_001589894.1| hypothetical protein SPAB_03726 [Salmon... 866 0.0
ref|YP_152017.1| protease III precursor (pitrilysin) [Salmo... 864 0.0
ref|ZP_02679542.1| protease III [Salmonella enterica subsp.... 863 0.0
ref|YP_001455683.1| hypothetical protein CKO_04186 [Citroba... 863 0.0
ref|XP_001695185.1| insulinase-like metalloprotease [Chlamy... 862 0.0
gb|EEH94306.1| protease III [Citrobacter sp. 30_2] 860 0.0
gb|EAZ13744.1| hypothetical protein OsJ_003569 [Oryza sativ... 856 0.0
ref|XP_001649937.1| metalloprotease [Aedes aegypti] >gi|108... 854 0.0
ref|ZP_01616823.1| Secreted/periplasmic Zn-dependent peptid... 854 0.0
ref|YP_001908664.1| Protease 3 precursor (Pitrilysin) [Erwi... 853 0.0
ref|YP_268860.1| zinc metallopeptidase, M16 family [Colwell... 849 0.0
ref|YP_001436619.1| hypothetical protein ESA_00488 [Enterob... 848 0.0
ref|ZP_03829109.1| protease III precursor [Pectobacterium c... 847 0.0
ref|ZP_01736964.1| Secreted/periplasmic Zn-dependent peptid... 846 0.0
ref|XP_001623609.1| predicted protein [Nematostella vectens... 846 0.0
ref|XP_001599332.1| PREDICTED: similar to metalloendopeptid... 846 0.0
gb|AAF63132.1|AC011001_2 Putative N-arginine dibasic conver... 845 0.0
ref|YP_339493.1| peptidase [Pseudoalteromonas haloplanktis ... 835 0.0
ref|ZP_01135442.1| zinc metallopeptidase, M16 family protei... 834 0.0
ref|ZP_01613408.1| protease III [Alteromonadales bacterium ... 832 0.0
ref|NP_567049.2| peptidase M16 family protein / insulinase ... 830 0.0
ref|ZP_01307403.1| Secreted/periplasmic Zn-dependent peptid... 829 0.0
ref|YP_269852.1| zinc metallopeptidase, M16 family [Colwell... 828 0.0
ref|ZP_01223918.1| peptidase, insulinase family protein [ma... 823 0.0
ref|NP_927976.1| Protease III precursor (pitrilysin) [Photo... 822 0.0
ref|ZP_01114527.1| Secreted/periplasmic Zn-dependent peptid... 819 0.0
ref|YP_455654.1| protease III precursor [Sodalis glossinidi... 818 0.0
emb|CAL51499.1| peptidase M16 family protein / insulinase f... 816 0.0
ref|ZP_01168295.1| zinc metallopeptidase, M16 family [Ocean... 815 0.0
ref|NP_001044431.1| Os01g0779100 [Oryza sativa (japonica cu... 813 0.0
ref|ZP_02959293.1| hypothetical protein PROSTU_01129 [Provi... 811 0.0
ref|XP_001434792.1| hypothetical protein GSPATT00006701001 ... 810 0.0
ref|XP_966800.1| PREDICTED: similar to Nardilysin precursor... 807 0.0
ref|ZP_01132694.1| putative peptidase [Pseudoalteromonas tu... 803 0.0
ref|XP_001024628.2| Insulysin, Insulin-degrading enzyme [Te... 802 0.0
ref|XP_001194830.1| PREDICTED: similar to Insulin-degrading... 800 0.0
ref|ZP_01625177.1| Secreted Zn-dependent peptidase, insulin... 799 0.0
ref|XP_001660612.1| metalloendopeptidase [Aedes aegypti] >g... 799 0.0
ref|ZP_01042947.1| Secreted Zn-dependent peptidase, insulin... 797 0.0
ref|XP_795975.2| PREDICTED: similar to Insulin-degrading en... 796 0.0
ref|XP_001449286.1| hypothetical protein GSPATT00016702001 ... 793 0.0
gb|ACO61422.1| predicted protein [Micromonas sp. RCC299] 792 0.0
ref|ZP_03841633.1| pitrilysin [Proteus mirabilis ATCC 29906... 791 0.0
ref|NP_504531.2| C02G6.2 [Caenorhabditis elegans] >gi|33620... 791 0.0
ref|XP_001031077.1| Insulysin, Insulin-degrading enzyme [Te... 791 0.0
ref|YP_156717.1| Secreted Zn-dependent peptidase, insulinas... 788 0.0
Sequences not found previously or not previously below threshold:
>ref|NP_013493.2| Metalloprotease involved, with homolog Axl1p, in N-terminal
processing of pro-a-factor to the mature form; member of
the insulin-degrading enzyme family; Ste23p
[Saccharomyces cerevisiae]
sp|Q06010|STE23_YEAST A-factor-processing enzyme
gb|AAB82351.2| Ste23p [Saccharomyces cerevisiae]
Length = 1027
Score = 1375 bits (3560), Expect = 0.0, Method: Composition-based stats.
Identities = 1027/1027 (100%), Positives = 1027/1027 (100%)
Query: 1 MGVSLLASSSAFVTKPLLTQLVHLSPISLNFTVRRFKPFTCLSRYYTTNPYNMTSNFKTF 60
MGVSLLASSSAFVTKPLLTQLVHLSPISLNFTVRRFKPFTCLSRYYTTNPYNMTSNFKTF
Sbjct: 1 MGVSLLASSSAFVTKPLLTQLVHLSPISLNFTVRRFKPFTCLSRYYTTNPYNMTSNFKTF 60
Query: 61 NLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNLPGLAHFC 120
NLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNLPGLAHFC
Sbjct: 61 NLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNLPGLAHFC 120
Query: 121 EHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGALDRFSGFFS 180
EHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGALDRFSGFFS
Sbjct: 121 EHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGALDRFSGFFS 180
Query: 181 CPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGTLP 240
CPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGTLP
Sbjct: 181 CPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGTLP 240
Query: 241 KENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGREVPLYAE 300
KENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGREVPLYAE
Sbjct: 241 KENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGREVPLYAE 300
Query: 301 PIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGSGSLLAHL 360
PIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGSGSLLAHL
Sbjct: 301 PIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGSGSLLAHL 360
Query: 361 KKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLPQKWI 420
KKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLPQKWI
Sbjct: 361 KKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLPQKWI 420
Query: 421 FNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILAMGLLTKYEPDLLTQYTD 480
FNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILAMGLLTKYEPDLLTQYTD
Sbjct: 421 FNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILAMGLLTKYEPDLLTQYTD 480
Query: 481 ALVPENSRVTLISRSLETDSAEKWYGTAYKVVDYPADLIKNMKSPGLNPALTLPRPNEFV 540
ALVPENSRVTLISRSLETDSAEKWYGTAYKVVDYPADLIKNMKSPGLNPALTLPRPNEFV
Sbjct: 481 ALVPENSRVTLISRSLETDSAEKWYGTAYKVVDYPADLIKNMKSPGLNPALTLPRPNEFV 540
Query: 541 STNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLPHTHASIINS 600
STNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLPHTHASIINS
Sbjct: 541 STNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLPHTHASIINS 600
Query: 601 MLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLIILLTRFLQGVN 660
MLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLIILLTRFLQGVN
Sbjct: 601 MLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLIILLTRFLQGVN 660
Query: 661 SFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKLQVFEKLTFE 720
SFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKLQVFEKLTFE
Sbjct: 661 SFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKLQVFEKLTFE 720
Query: 721 QLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIHNLQVSNNRLRSYLLPK 780
QLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIHNLQVSNNRLRSYLLPK
Sbjct: 721 QLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIHNLQVSNNRLRSYLLPK 780
Query: 781 GKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFAQLIHEPCFDTLRTKEQLGY 840
GKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFAQLIHEPCFDTLRTKEQLGY
Sbjct: 781 GKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFAQLIHEPCFDTLRTKEQLGY 840
Query: 841 VVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVLRDMPEEDFEKHKEALCN 900
VVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVLRDMPEEDFEKHKEALCN
Sbjct: 841 VVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVLRDMPEEDFEKHKEALCN 900
Query: 901 SLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMIDFYENYIMSENASK 960
SLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMIDFYENYIMSENASK
Sbjct: 901 SLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMIDFYENYIMSENASK 960
Query: 961 LILHLKSQVENKELNENELDTAKYPTGQLIEDVGAFKSTLFVAPVRQPMKDFEISAPPKL 1020
LILHLKSQVENKELNENELDTAKYPTGQLIEDVGAFKSTLFVAPVRQPMKDFEISAPPKL
Sbjct: 961 LILHLKSQVENKELNENELDTAKYPTGQLIEDVGAFKSTLFVAPVRQPMKDFEISAPPKL 1020
Query: 1021 NNSSESE 1027
NNSSESE
Sbjct: 1021 NNSSESE 1027
>gb|EDN59292.1| metalloprotease [Saccharomyces cerevisiae YJM789]
Length = 1027
Score = 1374 bits (3558), Expect = 0.0, Method: Composition-based stats.
Identities = 1021/1027 (99%), Positives = 1026/1027 (99%)
Query: 1 MGVSLLASSSAFVTKPLLTQLVHLSPISLNFTVRRFKPFTCLSRYYTTNPYNMTSNFKTF 60
MGVSLLASSSAFVTKPLLTQLVH SPISLNFTVRRFKPFTCLSRYYTTNPYNMTSNFKTF
Sbjct: 1 MGVSLLASSSAFVTKPLLTQLVHFSPISLNFTVRRFKPFTCLSRYYTTNPYNMTSNFKTF 60
Query: 61 NLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNLPGLAHFC 120
NLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDP+NLPGLAHFC
Sbjct: 61 NLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPENLPGLAHFC 120
Query: 121 EHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGALDRFSGFFS 180
EHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGALDRFSGFFS
Sbjct: 121 EHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGALDRFSGFFS 180
Query: 181 CPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGTLP 240
CPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGTLP
Sbjct: 181 CPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGTLP 240
Query: 241 KENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGREVPLYAE 300
KENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLS+WTYDLFKDVANNGREVPLYAE
Sbjct: 241 KENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSNWTYDLFKDVANNGREVPLYAE 300
Query: 301 PIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGSGSLLAHL 360
PIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGSGSLLAHL
Sbjct: 301 PIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGSGSLLAHL 360
Query: 361 KKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLPQKWI 420
KKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLPQKWI
Sbjct: 361 KKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLPQKWI 420
Query: 421 FNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILAMGLLTKYEPDLLTQYTD 480
FNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILAMGLLTKYEPDLLTQYTD
Sbjct: 421 FNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILAMGLLTKYEPDLLTQYTD 480
Query: 481 ALVPENSRVTLISRSLETDSAEKWYGTAYKVVDYPADLIKNMKSPGLNPALTLPRPNEFV 540
ALVPENSRVTLISRSLETDSAEKWYGTAYKVVDYPADLIKNMKSPGLNPALTLPRPNEFV
Sbjct: 481 ALVPENSRVTLISRSLETDSAEKWYGTAYKVVDYPADLIKNMKSPGLNPALTLPRPNEFV 540
Query: 541 STNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLPHTHASIINS 600
STNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLPHTHASIINS
Sbjct: 541 STNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLPHTHASIINS 600
Query: 601 MLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLIILLTRFLQGVN 660
MLSTLYTQLANDALKD+QYDAACADLRISFNKTNQGLAITASGFNEKLIILLTRFLQGVN
Sbjct: 601 MLSTLYTQLANDALKDLQYDAACADLRISFNKTNQGLAITASGFNEKLIILLTRFLQGVN 660
Query: 661 SFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKLQVFEKLTFE 720
SFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKLQVFEKLTFE
Sbjct: 661 SFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKLQVFEKLTFE 720
Query: 721 QLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIHNLQVSNNRLRSYLLPK 780
QLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIHNLQVSNNRLRSYLLPK
Sbjct: 721 QLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIHNLQVSNNRLRSYLLPK 780
Query: 781 GKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFAQLIHEPCFDTLRTKEQLGY 840
GKTFRYETALKDS+NVNSCIQHVTQLDVYSEDLSALSGLFAQLIHEPCFDTLRTKEQLGY
Sbjct: 781 GKTFRYETALKDSRNVNSCIQHVTQLDVYSEDLSALSGLFAQLIHEPCFDTLRTKEQLGY 840
Query: 841 VVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVLRDMPEEDFEKHKEALCN 900
VVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVLRDMPEEDFEKHKEALCN
Sbjct: 841 VVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVLRDMPEEDFEKHKEALCN 900
Query: 901 SLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMIDFYENYIMSENASK 960
SLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMIDFYENYIMSENASK
Sbjct: 901 SLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMIDFYENYIMSENASK 960
Query: 961 LILHLKSQVENKELNENELDTAKYPTGQLIEDVGAFKSTLFVAPVRQPMKDFEISAPPKL 1020
LILHLKSQVENKELNENELDTAKYPTGQLIEDVGAFKSTLFVAPVRQPMKDFEISAPPKL
Sbjct: 961 LILHLKSQVENKELNENELDTAKYPTGQLIEDVGAFKSTLFVAPVRQPMKDFEISAPPKL 1020
Query: 1021 NNSSESE 1027
NNSSES+
Sbjct: 1021 NNSSESD 1027
>ref|XP_001501085.1| PREDICTED: similar to insulin-degrading enzyme [Equus caballus]
Length = 1212
Score = 1168 bits (3022), Expect = 0.0, Method: Composition-based stats.
Identities = 372/982 (37%), Positives = 580/982 (59%), Gaps = 22/982 (2%)
Query: 48 TNPYNMTSNFKTFNLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAF 107
T K +K D+R YR ++L N +K LLI DP DK++A+LDV+IG+
Sbjct: 231 TYSKMNNPAIKRLGNHIIKSPEDKREYRGLQLANGIKVLLISDPTTDKSSAALDVHIGSL 290
Query: 108 EDPKNLPGLAHFCEHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQH 167
DP N+ GL+HFCEH+LF+G++K+P ENEYS +LS+H GSSNA+T+ ++TNY+F+V+H+H
Sbjct: 291 SDPPNIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEH 350
Query: 168 LFGALDRFSGFFSCPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHK 227
L GALDRF+ FF CPLF++ D+E+NAV+SE++KN+ ND WR++QL+K+ N KHP+ K
Sbjct: 351 LEGALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSK 410
Query: 228 FSTGNIETLGTLPKENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKD 287
F TGN TL T P + G++VR ELLKFH +YS+NLM +C+LGRE LD L+D LF +
Sbjct: 411 FGTGNKYTLETRPNQEGIDVRQELLKFHSTYYSSNLMAICVLGRESLDDLTDLVVKLFSE 470
Query: 288 VANNGREVPLYAEPIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHL 347
V N +P + E Q EHL+++ ++ P+KD++ L ++F +PD++++++S P L HL
Sbjct: 471 VENKNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHL 530
Query: 348 IGHEGSGSLLAHLKKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQY 407
IGHEG GSLL+ LK GW N L G ++G FF +++DLT+ GL H D+I+ +FQY
Sbjct: 531 IGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQY 590
Query: 408 IEMLKNSLPQKWIFNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRIL-AMGL 466
I+ L+ PQ+W+F E +D++ F+FK P S +A L Y P+ +L A L
Sbjct: 591 IQKLRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILH--YYPLEEVLTAEYL 648
Query: 467 LTKYEPDLLTQYTDALVPENSRVTLISRSLE--TDSAEKWYGTAYKVVDYPADLIKNMKS 524
L ++ PDL+ D L PEN RV ++S+S E TD E+WYGT Y+ P ++IK ++
Sbjct: 649 LEEFRPDLIEMVLDKLRPENVRVAVVSKSFEGKTDCTEEWYGTQYRQEAIPDEVIKKWQN 708
Query: 525 PGLNPALTLPRPNEFVSTNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYI 584
LN LP NEF+ TNF++ ++ + P L+ +SKLW+K+DD+F+ P+ +
Sbjct: 709 ADLNGKFKLPTKNEFIPTNFEILSLE-KEATPYPSLIKDTAMSKLWFKQDDKFFLPKACL 767
Query: 585 YLSFKLPHTHASIINSMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGF 644
F P + ++ ++ LY +L D+L + Y A A L T G+ ++ G+
Sbjct: 768 NFEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGY 827
Query: 645 NEKLIILLTRFLQGVNSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERS 704
N+K ILL + ++ + +FE + RFEI+K+ +R L N E P+ Y ++ E +
Sbjct: 828 NDKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVA 887
Query: 705 WSTAEKLQVFEKLTFEQLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIH 764
W+ E + + +T +L FIP + ++ E L+HGNI + AL + +++ + + H
Sbjct: 888 WTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAH 947
Query: 765 N---LQVSNNRLRSYLLPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFA 821
L R R LP F Y+ ++ + N I+ Q D+ S + LF
Sbjct: 948 TKPLLPSQLVRYREVQLPDRGWFVYQQ--RNEVHNNCGIEIYYQTDMQSTSENMFLELFC 1005
Query: 822 QLIHEPCFDTLRTKEQLGYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQ 881
Q+I EPCF+TLRTKEQLGY+VFS +G +R +IQSE YLE R+ F T +
Sbjct: 1006 QIISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEK 1065
Query: 882 VLRDMPEEDFEKHKEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANIT 941
+ DM EE F+KH +AL L K K ++ E A+Y I YNF + + +T
Sbjct: 1066 SIEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLT 1125
Query: 942 KQQMIDFYENYIM--SENASKLILHLKSQ------VENKELNENELDTAK---YPTGQLI 990
K+ +I FY+ + + K+ +H+ ++ V + +N+++ ++ P ++I
Sbjct: 1126 KEDIIKFYKEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPGLPQPEVI 1185
Query: 991 EDVGAFKSTLFVAPVRQPMKDF 1012
+++ FK L + P+ +P +F
Sbjct: 1186 QNMTEFKRGLPLFPLVKPHINF 1207
>ref|XP_001506502.1| PREDICTED: similar to insulin-degrading enzyme [Ornithorhynchus
anatinus]
Length = 1301
Score = 1166 bits (3016), Expect = 0.0, Method: Composition-based stats.
Identities = 381/1012 (37%), Positives = 590/1012 (58%), Gaps = 22/1012 (2%)
Query: 18 LTQLVHLSPISLNFTVRRFKPFTCLSRYYTTNPYNMTSNFKTFNLDFLKPDLDERSYRFI 77
LT + ++ SL+ T + S + S K + +K D+R YR +
Sbjct: 290 LTAVGAVAFRSLSQTRPVANARSSFSFQRYSYGKMDHSAVKRIVNNIIKSPEDKREYRGL 349
Query: 78 ELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNLPGLAHFCEHLLFMGSEKFPDENEY 137
EL N +KA+LI DP DK++A+LDV+IG+ DP N+ GL+HFCEH+LF+G++K+P ENEY
Sbjct: 350 ELANGIKAILISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKKYPKENEY 409
Query: 138 SSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGALDRFSGFFSCPLFNKDSTDKEINAVN 197
S +LS+H GSSNA+T+ ++TNY+F+V+H+HL GALDRF+ FF CPLF++ D+E+NAV+
Sbjct: 410 SQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKDREVNAVD 469
Query: 198 SENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGTLPKENGLNVRDELLKFHKN 257
SE++KN+ ND WR++QL+K+ N HP+ KF TGN TL T P + G++VR ELLKFH
Sbjct: 470 SEHEKNVMNDAWRLFQLEKATGNPNHPFSKFGTGNKYTLETRPTKEGIDVRQELLKFHST 529
Query: 258 FYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGREVPLYAEPIMQPEHLQKIIQVRPV 317
+YS+NLM +C+LGRE LD L+ LF +V N +P + E Q HL++I +V P+
Sbjct: 530 YYSSNLMAICVLGRESLDELTSLVVKLFSEVENKNVPLPEFPEHPFQEHHLRQIYKVVPI 589
Query: 318 KDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGSGSLLAHLKKLGWANELSAGGHTVS 377
KD++ L ++F +PD++++++S P L HLIGHEG GSLL+ LK GW N L G +
Sbjct: 590 KDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKAKGWVNTLVGGQKEGA 649
Query: 378 KGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLPQKWIFNELQDISNATFKFKQA 437
+G FF +++DLT+ GL H D+I+ +FQYI+ L+ PQ+W+F E +D++ F+FK
Sbjct: 650 RGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRTEGPQEWVFQECKDLNAVAFRFKDK 709
Query: 438 GSPSSTVSSLAKCLEKDYIPVSRILAM-GLLTKYEPDLLTQYTDALVPENSRVTLISRSL 496
P S L L Y P+ +LA LL ++ PDL+ D L PEN RV ++S+S
Sbjct: 710 ERPRGYTSKLGGMLH--YYPLEEVLAAEYLLEEFRPDLIEMVLDKLRPENVRVAIVSKSF 767
Query: 497 E--TDSAEKWYGTAYKVVDYPADLIKNMKSPGLNPALTLPRPNEFVSTNFKVDKIDGIKP 554
E TD E+WYGT YK ++IK ++ LN LP NEF+ +NF++ +++ P
Sbjct: 768 EGKTDQTEEWYGTQYKQEAISDEVIKKWQNADLNGKFKLPMKNEFIPSNFEILQLEKEAP 827
Query: 555 LDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLPHTHASIINSMLSTLYTQLANDAL 614
P L+ +SKLW+K+DD+F+ P+ + F P + ++ ++ LY +L D+L
Sbjct: 828 -SYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELLKDSL 886
Query: 615 KDVQYDAACADLRISFNKTNQGLAITASGFNEKLIILLTRFLQGVNSFEPKKDRFEILKD 674
+ Y A A L T G+ ++ G+N+K ILL + ++ + +FE + RFEI+K+
Sbjct: 887 NEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIVEKMATFEIDEKRFEIIKE 946
Query: 675 KTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKLQVFEKLTFEQLINFIPTIYEGVY 734
+R L N E P+ Y ++ E +W+ E + + +T +L FIP + ++
Sbjct: 947 AYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLH 1006
Query: 735 FETLIHGNIKHEEALEVDSLIKSLIPNNIHN---LQVSNNRLRSYLLPKGKTFRYETALK 791
E L+HGNI + AL V +++ + + H L R R LP F Y+ +
Sbjct: 1007 IEALLHGNITKQAALGVMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQ--R 1064
Query: 792 DSQNVNSCIQHVTQLDVYSEDLSALSGLFAQLIHEPCFDTLRTKEQLGYVVFSSSLNNHG 851
+ + N I+ Q D+ S + LF Q+I EPCF+TLRTKEQLGY+VFS +G
Sbjct: 1065 NEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRANG 1124
Query: 852 TANIRILIQSEHTTPYLEWRINNFYETFGQVLRDMPEEDFEKHKEALCNSLLQKFKNMAE 911
+R +IQSE YLE R+ F T + + DM EE F+KH +AL L K K ++
Sbjct: 1125 IQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKLSA 1184
Query: 912 ESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMIDFYENYIM--SENASKLILHLKSQ- 968
E A+Y I YNF + + +TK+ +I FY+ + + K+ +H+ ++
Sbjct: 1185 ECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIRFYKEMLAVEAPRRHKVSVHVLARE 1244
Query: 969 -----VENKELNENELDTA---KYPTGQLIEDVGAFKSTLFVAPVRQPMKDF 1012
V + +N+++ A P ++IE++ AFK +L + P+ +P +
Sbjct: 1245 MDSCPVVGEFPCQNDVNLAAAPALPQPEVIENMTAFKRSLPLFPLVKPHINL 1296
>ref|XP_001646584.1| hypothetical protein Kpol_1055p83 [Vanderwaltozyma polyspora DSM
70294]
gb|EDO18726.1| hypothetical protein Kpol_1055p83 [Vanderwaltozyma polyspora DSM
70294]
Length = 1020
Score = 1147 bits (2968), Expect = 0.0, Method: Composition-based stats.
Identities = 664/1016 (65%), Positives = 842/1016 (82%), Gaps = 6/1016 (0%)
Query: 4 SLLASSSAFVTKPLLTQLVHLSPISLNFTVRRFKPFTCLSRYYTTNPYNMTSNFKTFNLD 63
SLL++ V + T L S+ +R F R +T +K +L+
Sbjct: 9 SLLSNIGISVKSNVPTILSR----SIPLYLRNFTKINYYKRKMSTTSDVTKKPYKIHDLN 64
Query: 64 FLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNLPGLAHFCEHL 123
F+KPDLD+RSYRFIELPNK KALLI D DK+AASLDVNIGAF+DPKNL GLAHFCEHL
Sbjct: 65 FIKPDLDDRSYRFIELPNKFKALLIHDASTDKSAASLDVNIGAFQDPKNLQGLAHFCEHL 124
Query: 124 LFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGALDRFSGFFSCPL 183
LFMGS+KFP+ENEYSSYL+KHGGSSNAYT +QNTNYFFE+NH+HL GALDRFSGFF+CPL
Sbjct: 125 LFMGSKKFPNENEYSSYLNKHGGSSNAYTGAQNTNYFFEINHEHLHGALDRFSGFFTCPL 184
Query: 184 FNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGTLPKEN 243
FN +ST KEINAV+SENKKNLQND+WR+YQLDKSL+N KHPYHKFSTGN++TL +PK+
Sbjct: 185 FNPNSTSKEINAVDSENKKNLQNDVWRMYQLDKSLSNEKHPYHKFSTGNLKTLDEMPKKE 244
Query: 244 GLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGREVPLYAEPIM 303
GL++R+ELLKF+ + YSANLMKLC+LGREDLDT+SDW Y+LF+ V NN R +P Y EPI+
Sbjct: 245 GLDIRNELLKFYSDSYSANLMKLCVLGREDLDTMSDWVYNLFEAVPNNNRPLPEYNEPIL 304
Query: 304 QPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGSGSLLAHLKKL 363
E+L+KII V+PVKDLKKLEI+F DM+ WESKP ILSHLIGHEGSGS+L+HLK L
Sbjct: 305 LEENLKKIIHVKPVKDLKKLEITFLAQDMDLFWESKPQHILSHLIGHEGSGSILSHLKTL 364
Query: 364 GWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLPQKWIFNE 423
WANELSAGGHTVSK NAFF++DIDLT+NG HY++++ ++FQYIEMLK SLPQ+ IF E
Sbjct: 365 SWANELSAGGHTVSKDNAFFSIDIDLTENGFQHYKEIVHIVFQYIEMLKISLPQERIFLE 424
Query: 424 LQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILAMGLLTKYEPDLLTQYTDALV 483
LQDI+NA+FKFKQ +PSSTVS+L+K LEK+YIPV IL+ GL KY+P+++ Y ++L
Sbjct: 425 LQDIANASFKFKQKVNPSSTVSNLSKALEKEYIPVENILSTGLFRKYDPEIMKNYVNSLS 484
Query: 484 PENSRVTLISRSLETDSAEKWYGTAYKVVDYPADLIKNMKSPGLNPALTLPRPNEFVSTN 543
P+NSR+TL +++ETDS E WYGT Y+V DYP DL +KSPGLNP L++PRPNEF++TN
Sbjct: 485 PDNSRITLAGKAVETDSKETWYGTDYRVEDYPKDLYDTIKSPGLNPNLSIPRPNEFIATN 544
Query: 544 FKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLPHTHASIINSMLS 603
F V+K D +PL EP+LL VSKLWYKKDDRFWQPRG+IY++ KLPHT AS+IN++L+
Sbjct: 545 FDVEKFDVNEPLVEPLLLKDSPVSKLWYKKDDRFWQPRGFIYITMKLPHTQASVINNLLT 604
Query: 604 TLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLIILLTRFLQGVNSFE 663
+LY QL ND+LKD+QYDAACA+L +SF+KTNQGL IT SGFN+KLI+LL RF+ GV+ ++
Sbjct: 605 SLYVQLVNDSLKDLQYDAACANLHLSFSKTNQGLDITISGFNDKLIVLLQRFIYGVSVYQ 664
Query: 664 PKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKLQVFEKLTFEQLI 723
P K RF+I K+KTI++LKN LYEVPYSQ+S Y+++INER+WS +KL + EK+T+EQ +
Sbjct: 665 PSKLRFKIFKEKTIQNLKNCLYEVPYSQISTLYSSLINERTWSVKQKLSIIEKITYEQFL 724
Query: 724 NFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIHNLQVSNNRLRSYLLPKGKT 783
F+PTIYE YF+ L+HGN ++EEA+E+DSL++SLI +I NL V N RLRSY++P G+T
Sbjct: 725 AFLPTIYEECYFDGLVHGNFRNEEAVEIDSLVQSLITTDIVNLHVKNTRLRSYVIPNGET 784
Query: 784 FRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFAQLIHEPCFDTLRTKEQLGYVVF 843
+R+E L+D++NVNSC+QHV QL YSE+LSA+SGLFAQ+++EPCFDTLRTKEQLGYVVF
Sbjct: 785 YRFEIDLEDAENVNSCVQHVVQLGGYSEELSAMSGLFAQILNEPCFDTLRTKEQLGYVVF 844
Query: 844 SSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVLRDMPEEDFEKHKEALCNSLL 903
SSSLNNHGTANIRIL+QSEH+TPYLEWRI+ FY++FG+ LR+M +++ EKHK+ALC SL+
Sbjct: 845 SSSLNNHGTANIRILVQSEHSTPYLEWRIDEFYKSFGETLRNMSDDELEKHKDALCKSLM 904
Query: 904 QKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMIDFYENYIMSENASKLIL 963
QK+KNM EE++RYTAAIYLGDYNFTHRQKKA LVA I+K Q+I F+E++ +S NA+KL++
Sbjct: 905 QKYKNMKEENSRYTAAIYLGDYNFTHRQKKANLVAQISKDQLIKFFEDHFISANAAKLVI 964
Query: 964 HLKSQVEN--KELNENELDTAKYPTGQLIEDVGAFKSTLFVAPVRQPMKDFEISAP 1017
HLKS+V++ K++NE++LD KYPTG+LI DV FKS L+ AP+RQP+K F++ P
Sbjct: 965 HLKSKVKSSDKDINEDKLDVKKYPTGKLITDVDEFKSKLYAAPIRQPLKKFDVYKP 1020
>ref|NP_004960.2| insulysin [Homo sapiens]
emb|CAI13670.1| insulin-degrading enzyme [Homo sapiens]
gb|AAH96337.1| Insulin-degrading enzyme [Homo sapiens]
gb|AAH96339.1| Insulin-degrading enzyme [Homo sapiens]
gb|AAH96336.1| Insulin-degrading enzyme [Homo sapiens]
gb|EAW50090.1| insulin-degrading enzyme, isoform CRA_a [Homo sapiens]
gb|EAW50091.1| insulin-degrading enzyme, isoform CRA_a [Homo sapiens]
Length = 1019
Score = 1137 bits (2941), Expect = 0.0, Method: Composition-based stats.
Identities = 373/982 (37%), Positives = 579/982 (58%), Gaps = 22/982 (2%)
Query: 48 TNPYNMTSNFKTFNLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAF 107
T K K D+R YR +EL N +K LLI DP DK++A+LDV+IG+
Sbjct: 38 TYSKMNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSL 97
Query: 108 EDPKNLPGLAHFCEHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQH 167
DP N+ GL+HFCEH+LF+G++K+P ENEYS +LS+H GSSNA+T+ ++TNY+F+V+H+H
Sbjct: 98 SDPPNIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEH 157
Query: 168 LFGALDRFSGFFSCPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHK 227
L GALDRF+ FF CPLF++ D+E+NAV+SE++KN+ ND WR++QL+K+ N KHP+ K
Sbjct: 158 LEGALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSK 217
Query: 228 FSTGNIETLGTLPKENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKD 287
F TGN TL T P + G++VR ELLKFH +YS+NLM +C+LGRE LD L++ LF +
Sbjct: 218 FGTGNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSE 277
Query: 288 VANNGREVPLYAEPIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHL 347
V N +P + E Q EHL+++ ++ P+KD++ L ++F +PD++++++S P L HL
Sbjct: 278 VENKNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHL 337
Query: 348 IGHEGSGSLLAHLKKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQY 407
IGHEG GSLL+ LK GW N L G ++G FF +++DLT+ GL H D+I+ +FQY
Sbjct: 338 IGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQY 397
Query: 408 IEMLKNSLPQKWIFNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRIL-AMGL 466
I+ L+ PQ+W+F E +D++ F+FK P S +A L Y P+ +L A L
Sbjct: 398 IQKLRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILH--YYPLEEVLTAEYL 455
Query: 467 LTKYEPDLLTQYTDALVPENSRVTLISRSLE--TDSAEKWYGTAYKVVDYPADLIKNMKS 524
L ++ PDL+ D L PEN RV ++S+S E TD E+WYGT YK P ++IK ++
Sbjct: 456 LEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQN 515
Query: 525 PGLNPALTLPRPNEFVSTNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYI 584
LN LP NEF+ TNF++ ++ + P L+ +SKLW+K+DD+F+ P+ +
Sbjct: 516 ADLNGKFKLPTKNEFIPTNFEILPLE-KEATPYPALIKDTAMSKLWFKQDDKFFLPKACL 574
Query: 585 YLSFKLPHTHASIINSMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGF 644
F P + ++ ++ LY +L D+L + Y A A L T G+ ++ G+
Sbjct: 575 NFEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGY 634
Query: 645 NEKLIILLTRFLQGVNSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERS 704
N+K ILL + ++ + +FE + RFEI+K+ +R L N E P+ Y ++ E +
Sbjct: 635 NDKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVA 694
Query: 705 WSTAEKLQVFEKLTFEQLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIH 764
W+ E + + +T +L FIP + ++ E L+HGNI + AL + +++ + + H
Sbjct: 695 WTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAH 754
Query: 765 N---LQVSNNRLRSYLLPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFA 821
L R R LP F Y+ ++ + N I+ Q D+ S + LF
Sbjct: 755 TKPLLPSQLVRYREVQLPDRGWFVYQQ--RNEVHNNCGIEIYYQTDMQSTSENMFLELFC 812
Query: 822 QLIHEPCFDTLRTKEQLGYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQ 881
Q+I EPCF+TLRTKEQLGY+VFS +G +R +IQSE YLE R+ F T +
Sbjct: 813 QIISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEK 872
Query: 882 VLRDMPEEDFEKHKEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANIT 941
+ DM EE F+KH +AL L K K ++ E A+Y I YNF + + +T
Sbjct: 873 SIEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLT 932
Query: 942 KQQMIDFYENYIM--SENASKLILHLKSQ------VENKELNENELDTAK---YPTGQLI 990
K+ +I FY+ + + K+ +H+ ++ V + +N+++ ++ P ++I
Sbjct: 933 KEDIIKFYKEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVI 992
Query: 991 EDVGAFKSTLFVAPVRQPMKDF 1012
+++ FK L + P+ +P +F
Sbjct: 993 QNMTEFKRGLPLFPLVKPHINF 1014
>ref|XP_001090249.1| PREDICTED: insulysin isoform 3 [Macaca mulatta]
Length = 1019
Score = 1136 bits (2940), Expect = 0.0, Method: Composition-based stats.
Identities = 372/982 (37%), Positives = 579/982 (58%), Gaps = 22/982 (2%)
Query: 48 TNPYNMTSNFKTFNLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAF 107
T K K D+R YR +EL N +K LLI DP DK++A+LDV+IG+
Sbjct: 38 TYSKMNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSL 97
Query: 108 EDPKNLPGLAHFCEHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQH 167
DP N+ GL+HFCEH+LF+G++K+P ENEYS +LS+H GSSNA+T+ ++TNY+F+V+H+H
Sbjct: 98 SDPPNIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEH 157
Query: 168 LFGALDRFSGFFSCPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHK 227
L GALDRF+ FF CPLF++ D+E+NAV+SE++KN+ ND WR++QL+K+ N KHP+ K
Sbjct: 158 LEGALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSK 217
Query: 228 FSTGNIETLGTLPKENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKD 287
F TGN TL T P + G++VR ELLKFH +YS+NLM +C+LGRE LD L++ LF +
Sbjct: 218 FGTGNKYTLETRPNQEGIDVRQELLKFHSTYYSSNLMAVCVLGRESLDDLTNLVVKLFSE 277
Query: 288 VANNGREVPLYAEPIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHL 347
V N +P + E Q EHL+++ ++ P+KD++ L ++F +PD++++++S P L HL
Sbjct: 278 VENKSVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHL 337
Query: 348 IGHEGSGSLLAHLKKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQY 407
IGHEG GSLL+ LK GW N L G ++G FF +++DLT+ GL H D+I+ +FQY
Sbjct: 338 IGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQY 397
Query: 408 IEMLKNSLPQKWIFNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRIL-AMGL 466
I+ L+ PQ+W+F E +D++ F+FK P S +A L Y P+ +L A L
Sbjct: 398 IQKLRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILH--YYPLEEVLTAEYL 455
Query: 467 LTKYEPDLLTQYTDALVPENSRVTLISRSLE--TDSAEKWYGTAYKVVDYPADLIKNMKS 524
L ++ PDL+ D L PEN RV ++S+S E TD E+WYGT YK P ++IK ++
Sbjct: 456 LEEFRPDLIEMVLDKLRPENVRVAVVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQN 515
Query: 525 PGLNPALTLPRPNEFVSTNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYI 584
LN LP NEF+ TNF++ ++ + P L+ +SKLW+K+DD+F+ P+ +
Sbjct: 516 ADLNGKFKLPTKNEFIPTNFEILPLE-KEATPYPALIKDTAMSKLWFKQDDKFFLPKACL 574
Query: 585 YLSFKLPHTHASIINSMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGF 644
F P + ++ ++ LY +L D+L + Y A A L T G+ ++ G+
Sbjct: 575 NFEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGY 634
Query: 645 NEKLIILLTRFLQGVNSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERS 704
N+K ILL + ++ + +FE + RFEI+K+ +R L N E P+ Y ++ E +
Sbjct: 635 NDKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVA 694
Query: 705 WSTAEKLQVFEKLTFEQLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIH 764
W+ E + + +T +L FIP + ++ E L+HGNI + AL + +++ + + H
Sbjct: 695 WTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAH 754
Query: 765 N---LQVSNNRLRSYLLPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFA 821
L R R LP F Y+ ++ + N I+ Q D+ S + LF
Sbjct: 755 TKPLLPSQLVRYREVQLPDRGWFVYQQ--RNEVHNNCGIEIYYQTDMQSTSENMFLELFC 812
Query: 822 QLIHEPCFDTLRTKEQLGYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQ 881
Q+I EPCF+TLRTKEQLGY+VFS +G +R +IQSE YLE R+ F T +
Sbjct: 813 QIISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEK 872
Query: 882 VLRDMPEEDFEKHKEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANIT 941
+ DM EE F+KH +AL L K K ++ E A+Y I Y+F + + +T
Sbjct: 873 SIEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYHFDRDNTEVAYLKTLT 932
Query: 942 KQQMIDFYENYIM--SENASKLILHLKSQ------VENKELNENELDTAK---YPTGQLI 990
K+ +I FY+ + + K+ +H+ ++ V + +N+++ ++ P ++I
Sbjct: 933 KEDIIKFYKEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVI 992
Query: 991 EDVGAFKSTLFVAPVRQPMKDF 1012
+++ FK L + P+ +P +F
Sbjct: 993 QNMTEFKRGLPLFPLVKPHINF 1014
>ref|XP_507922.2| PREDICTED: insulysin isoform 4 [Pan troglodytes]
Length = 1019
Score = 1136 bits (2940), Expect = 0.0, Method: Composition-based stats.
Identities = 373/982 (37%), Positives = 579/982 (58%), Gaps = 22/982 (2%)
Query: 48 TNPYNMTSNFKTFNLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAF 107
T K K D+R YR +EL N +K LLI DP DK++A+LDV+IG+
Sbjct: 38 TYSKMNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSL 97
Query: 108 EDPKNLPGLAHFCEHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQH 167
DP N+ GL+HFCEH+LF+G++K+P ENEYS +LS+H GSSNA+T+ ++TNY+F+V+H+H
Sbjct: 98 SDPPNIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEH 157
Query: 168 LFGALDRFSGFFSCPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHK 227
L GALDRF+ FF CPLF++ D+E+NAV+SE++KN+ ND WR++QL+K+ N KHP+ K
Sbjct: 158 LEGALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSK 217
Query: 228 FSTGNIETLGTLPKENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKD 287
F TGN TL T P + G++VR ELLKFH +YS+NLM +C+LGRE LD L++ LF +
Sbjct: 218 FGTGNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSE 277
Query: 288 VANNGREVPLYAEPIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHL 347
V N +P + E Q EHL+++ ++ P+KD++ L ++F +PD++++++S P L HL
Sbjct: 278 VENKNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHL 337
Query: 348 IGHEGSGSLLAHLKKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQY 407
IGHEG GSLL+ LK GW N L G ++G FF +++DLT+ GL H D+I+ +FQY
Sbjct: 338 IGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQY 397
Query: 408 IEMLKNSLPQKWIFNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRIL-AMGL 466
I+ L+ PQ+W+F E +D++ F+FK P S +A L Y P+ +L A L
Sbjct: 398 IQKLRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILH--YYPLEEVLTAEYL 455
Query: 467 LTKYEPDLLTQYTDALVPENSRVTLISRSLE--TDSAEKWYGTAYKVVDYPADLIKNMKS 524
L ++ PDL+ D L PEN RV ++S+S E TD E+WYGT YK P ++IK ++
Sbjct: 456 LEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQN 515
Query: 525 PGLNPALTLPRPNEFVSTNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYI 584
LN LP NEF+ TNF++ ++ + P L+ +SKLW+K+DD+F+ P+ +
Sbjct: 516 ADLNGKFKLPTKNEFIPTNFEILPLE-KEATPYPALIKDTAMSKLWFKQDDKFFLPKACL 574
Query: 585 YLSFKLPHTHASIINSMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGF 644
F P + ++ ++ LY +L D+L + Y A A L T G+ ++ G+
Sbjct: 575 NFEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGY 634
Query: 645 NEKLIILLTRFLQGVNSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERS 704
N+K ILL + ++ + +FE + RFEI+K+ +R L N E P+ Y ++ E +
Sbjct: 635 NDKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVA 694
Query: 705 WSTAEKLQVFEKLTFEQLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIH 764
W+ E + + +T +L FIP + ++ E L+HGNI + AL + +++ + + H
Sbjct: 695 WTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAH 754
Query: 765 N---LQVSNNRLRSYLLPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFA 821
L R R LP F Y+ ++ + N I+ Q D+ S + LF
Sbjct: 755 TKPLLPSQLVRYREVQLPDRGWFVYQQ--RNEVHNNCGIEIYYQTDMQSTSENMFLELFC 812
Query: 822 QLIHEPCFDTLRTKEQLGYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQ 881
Q+I EPCF+TLRTKEQLGY+VFS +G +R +IQSE YLE R+ F T +
Sbjct: 813 QIISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEK 872
Query: 882 VLRDMPEEDFEKHKEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANIT 941
+ DM EE F+KH +AL L K K ++ E A+Y I YNF + + +T
Sbjct: 873 SIEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLT 932
Query: 942 KQQMIDFYENYIM--SENASKLILHLKSQ------VENKELNENELDTAK---YPTGQLI 990
K+ +I FY+ + + K+ +H+ ++ V + +N+++ ++ P ++I
Sbjct: 933 KEDIIKFYKEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVI 992
Query: 991 EDVGAFKSTLFVAPVRQPMKDF 1012
+++ FK L + P+ +P +F
Sbjct: 993 QNMTEFKRGLPLFPLVKPHINF 1014
>ref|XP_001276340.1| a-pheromone processing metallopeptidase Ste23 [Aspergillus clavatus
NRRL 1]
gb|EAW14914.1| a-pheromone processing metallopeptidase Ste23 [Aspergillus clavatus
NRRL 1]
Length = 1156
Score = 1132 bits (2929), Expect = 0.0, Method: Composition-based stats.
Identities = 397/994 (39%), Positives = 589/994 (59%), Gaps = 21/994 (2%)
Query: 3 VSLLASSS---AFVTKPLLTQLVHLSPISLNFTVRRFKPFTCLSRYYTTNPYNMTSNFKT 59
VS LAS++ F + L + L P+ ++T R F C ++ M S +
Sbjct: 31 VSTLASAAIAPPFSSSLRLRPICSLHPLPGSWTRRSFSRSAC--APFSAGNLTMGS-IEH 87
Query: 60 FNLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNLPGLAHF 119
KP+LD+RSYR I LPNKL+ALL+ DP DKA+AS++VN+G F D ++PG+AH
Sbjct: 88 LTESLEKPELDDRSYRVIRLPNKLEALLVHDPDTDKASASVNVNVGNFSDADDMPGMAHA 147
Query: 120 CEHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGALDRFSGFF 179
EHLLFMG++KFP EN Y+ YL+ H GSSNAYTA+ TNYFFE L+GALDRF+ FF
Sbjct: 148 VEHLLFMGTKKFPKENAYNQYLASHSGSSNAYTAATETNYFFE-PSSPLYGALDRFAQFF 206
Query: 180 SCPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGTL 239
PLF + + D+E+ AV+SENKKNLQ+D+WR+ QL+KSL+N HPYH FSTGN++TL
Sbjct: 207 VSPLFLESTLDRELRAVDSENKKNLQSDLWRLMQLNKSLSNPGHPYHHFSTGNLKTLKED 266
Query: 240 PKENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGREVPLYA 299
P++ GL VR E +KF++ YSAN M+LC+LGRE LD L W +LF +V N +
Sbjct: 267 PEKRGLEVRSEFIKFYEKHYSANRMRLCVLGRESLDELEKWVEELFSEVENKDLPQNRWD 326
Query: 300 E-PIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGSGSLLA 358
+ +PE L I +PV D + L+I F D E +ES+P R +SHLIGHEG GS+LA
Sbjct: 327 DVQPWRPEDLGVQIFAKPVMDNRSLDIYFPFLDEEYLYESQPSRYISHLIGHEGPGSILA 386
Query: 359 HLKKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLPQK 418
++K GWAN LSAG + G+A F + I LT GL YR+V ++F+YI MLK PQ+
Sbjct: 387 YIKAKGWANGLSAGVMPICPGSAAFTISIRLTKEGLQQYREVAKVVFEYIAMLKEREPQQ 446
Query: 419 WIFNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILAMGLLTKYEPDLLTQY 478
W+F+E+++++ F+FKQ S S L+ ++K +P +L+ LL K++P+L+ +
Sbjct: 447 WVFDEMKNLAEVEFRFKQKSPASRFTSRLSSVMQKP-MPREWLLSGSLLRKFDPELIKKA 505
Query: 479 TDALVPENSRVTLISRSLE--TDSAEKWYGTAYKVVDYPADLIKNMKSP------GLNPA 530
L P+N R+ ++S+ DS EKWYGT YKV P D + ++K+
Sbjct: 506 LACLQPDNFRMIVVSQEHPGDWDSKEKWYGTEYKVQKLPQDFMADIKNALATTPETRLSE 565
Query: 531 LTLPRPNEFVSTNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKL 590
L +P NEFV T V+K D +P P L+ D+ +LW+KKDDRFW P+G ++++ +
Sbjct: 566 LHMPHENEFVPTRLSVEKKDISEPAKTPKLIRHDEHVRLWFKKDDRFWVPKGTVHITLRN 625
Query: 591 PHTHASIINSMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLII 650
P A+ N + S LY +L DAL + YDA A L + + GL I+ G+N+K+ +
Sbjct: 626 PLAWATPANLVKSKLYCELVKDALVEYSYDAELAGLDYHLSASVFGLDISVGGYNDKMAV 685
Query: 651 LLTRFLQGVNSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEK 710
LL + L + DRF I+K++ R +N Y+ P+ Q+ +Y + E++W +
Sbjct: 686 LLEKVLTSMRDLVVNPDRFHIIKERLSRGYRNAEYQQPFYQVGDYTRHLTAEKTWINEQY 745
Query: 711 LQVFEKLTFEQLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIHNLQVSN 770
E + E + NF P + + + E L HGN+ E+AL + L+++++ + +
Sbjct: 746 AAELEHIEPEDISNFFPQLLQQNHVEVLAHGNLYKEDALRMTDLVENVLQSRPLPQSQWH 805
Query: 771 NRLRSYLLPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSED-LSALSGLFAQLIHEPCF 829
R R+ ++P G + YE L+D NVN CI++ + +D L A LFAQ+ EP F
Sbjct: 806 VR-RNIIIPPGSNYVYERTLQDPANVNHCIEYYVYVGSIRDDILRAKLLLFAQMTDEPAF 864
Query: 830 DTLRTKEQLGYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVLRDMPEE 889
D LR+KEQLGYVV+S + + T R++IQSE T YLE RI+NF G+ L +M ++
Sbjct: 865 DQLRSKEQLGYVVWSGARYSATTIGYRVIIQSERTAEYLESRIDNFLIQAGETLENMSDK 924
Query: 890 DFEKHKEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMIDFY 949
DFE HK ++ N L+K KN++ E++R+ + I ++F + A V +TK ++DFY
Sbjct: 925 DFEGHKRSVVNKRLEKLKNLSSETSRFWSHIGSEYFDFVQNETDAANVRTLTKADIVDFY 984
Query: 950 ENYI--MSENASKLILHLKSQVENKELNENELDT 981
+ I S KL ++L +Q + +
Sbjct: 985 KQLIDPRSPTRGKLSIYLNAQAGGHTHTIDPKEQ 1018
>ref|XP_001146520.1| PREDICTED: insulysin isoform 2 [Pan troglodytes]
gb|EAW50093.1| insulin-degrading enzyme, isoform CRA_c [Homo sapiens]
Length = 978
Score = 1132 bits (2928), Expect = 0.0, Method: Composition-based stats.
Identities = 372/976 (38%), Positives = 578/976 (59%), Gaps = 22/976 (2%)
Query: 54 TSNFKTFNLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNL 113
K K D+R YR +EL N +K LLI DP DK++A+LDV+IG+ DP N+
Sbjct: 3 NPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNI 62
Query: 114 PGLAHFCEHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGALD 173
GL+HFCEH+LF+G++K+P ENEYS +LS+H GSSNA+T+ ++TNY+F+V+H+HL GALD
Sbjct: 63 AGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALD 122
Query: 174 RFSGFFSCPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNI 233
RF+ FF CPLF++ D+E+NAV+SE++KN+ ND WR++QL+K+ N KHP+ KF TGN
Sbjct: 123 RFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNK 182
Query: 234 ETLGTLPKENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGR 293
TL T P + G++VR ELLKFH +YS+NLM +C+LGRE LD L++ LF +V N
Sbjct: 183 YTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNV 242
Query: 294 EVPLYAEPIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGS 353
+P + E Q EHL+++ ++ P+KD++ L ++F +PD++++++S P L HLIGHEG
Sbjct: 243 PLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGP 302
Query: 354 GSLLAHLKKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKN 413
GSLL+ LK GW N L G ++G FF +++DLT+ GL H D+I+ +FQYI+ L+
Sbjct: 303 GSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRA 362
Query: 414 SLPQKWIFNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRIL-AMGLLTKYEP 472
PQ+W+F E +D++ F+FK P S +A L Y P+ +L A LL ++ P
Sbjct: 363 EGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILH--YYPLEEVLTAEYLLEEFRP 420
Query: 473 DLLTQYTDALVPENSRVTLISRSLE--TDSAEKWYGTAYKVVDYPADLIKNMKSPGLNPA 530
DL+ D L PEN RV ++S+S E TD E+WYGT YK P ++IK ++ LN
Sbjct: 421 DLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGK 480
Query: 531 LTLPRPNEFVSTNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKL 590
LP NEF+ TNF++ ++ + P L+ +SKLW+K+DD+F+ P+ + F
Sbjct: 481 FKLPTKNEFIPTNFEILPLE-KEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFS 539
Query: 591 PHTHASIINSMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLII 650
P + ++ ++ LY +L D+L + Y A A L T G+ ++ G+N+K I
Sbjct: 540 PFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPI 599
Query: 651 LLTRFLQGVNSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEK 710
LL + ++ + +FE + RFEI+K+ +R L N E P+ Y ++ E +W+ E
Sbjct: 600 LLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDEL 659
Query: 711 LQVFEKLTFEQLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIHN---LQ 767
+ + +T +L FIP + ++ E L+HGNI + AL + +++ + + H L
Sbjct: 660 KEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLP 719
Query: 768 VSNNRLRSYLLPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFAQLIHEP 827
R R LP F Y+ ++ + N I+ Q D+ S + LF Q+I EP
Sbjct: 720 SQLVRYREVQLPDRGWFVYQQ--RNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEP 777
Query: 828 CFDTLRTKEQLGYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVLRDMP 887
CF+TLRTKEQLGY+VFS +G +R +IQSE YLE R+ F T + + DM
Sbjct: 778 CFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMT 837
Query: 888 EEDFEKHKEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMID 947
EE F+KH +AL L K K ++ E A+Y I YNF + + +TK+ +I
Sbjct: 838 EEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIK 897
Query: 948 FYENYIM--SENASKLILHLKSQ------VENKELNENELDTAK---YPTGQLIEDVGAF 996
FY+ + + K+ +H+ ++ V + +N+++ ++ P ++I+++ F
Sbjct: 898 FYKEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEF 957
Query: 997 KSTLFVAPVRQPMKDF 1012
K L + P+ +P +F
Sbjct: 958 KRGLPLFPLVKPHINF 973
>pdb|2G47|A Chain A, Crystal Structure Of Human Insulin-Degrading Enzyme In
Complex With Amyloid-Beta (1-40)
pdb|2G47|B Chain B, Crystal Structure Of Human Insulin-Degrading Enzyme In
Complex With Amyloid-Beta (1-40)
pdb|2G48|A Chain A, Crystal Structure Of Human Insulin-Degrading Enzyme In
Complex With Amylin
pdb|2G48|B Chain B, Crystal Structure Of Human Insulin-Degrading Enzyme In
Complex With Amylin
pdb|2G49|A Chain A, Crystal Structure Of Human Insulin-Degrading Enzyme In
Complex With Glucagon
pdb|2G49|B Chain B, Crystal Structure Of Human Insulin-Degrading Enzyme In
Complex With Glucagon
pdb|2G54|A Chain A, Crystal Structure Of Zn-Bound Human Insulin-Degrading Enzyme
In Complex With Insulin B Chain
pdb|2G54|B Chain B, Crystal Structure Of Zn-Bound Human Insulin-Degrading Enzyme
In Complex With Insulin B Chain
pdb|2G56|A Chain A, Crystal Structure Of Human Insulin-Degrading Enzyme In
Complex With Insulin B Chain
pdb|2G56|B Chain B, Crystal Structure Of Human Insulin-Degrading Enzyme In
Complex With Insulin B Chain
pdb|2JBU|A Chain A, Crystal Structure Of Human Insulin Degrading Enzyme
Complexed With Co-Purified Peptides.
pdb|2JBU|B Chain B, Crystal Structure Of Human Insulin Degrading Enzyme
Complexed With Co-Purified Peptides.
Length = 990
Score = 1131 bits (2927), Expect = 0.0, Method: Composition-based stats.
Identities = 371/976 (38%), Positives = 578/976 (59%), Gaps = 22/976 (2%)
Query: 54 TSNFKTFNLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNL 113
K K D+R YR +EL N +K LLI DP DK++A+LDV+IG+ DP N+
Sbjct: 15 NPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNI 74
Query: 114 PGLAHFCEHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGALD 173
GL+HFC+H+LF+G++K+P ENEYS +LS+H GSSNA+T+ ++TNY+F+V+H+HL GALD
Sbjct: 75 AGLSHFCQHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALD 134
Query: 174 RFSGFFSCPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNI 233
RF+ FF CPLF++ D+E+NAV+SE++KN+ ND WR++QL+K+ N KHP+ KF TGN
Sbjct: 135 RFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNK 194
Query: 234 ETLGTLPKENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGR 293
TL T P + G++VR ELLKFH +YS+NLM +C+LGRE LD L++ LF +V N
Sbjct: 195 YTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNV 254
Query: 294 EVPLYAEPIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGS 353
+P + E Q EHL+++ ++ P+KD++ L ++F +PD++++++S P L HLIGHEG
Sbjct: 255 PLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGP 314
Query: 354 GSLLAHLKKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKN 413
GSLL+ LK GW N L G ++G FF +++DLT+ GL H D+I+ +FQYI+ L+
Sbjct: 315 GSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRA 374
Query: 414 SLPQKWIFNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRIL-AMGLLTKYEP 472
PQ+W+F E +D++ F+FK P S +A L Y P+ +L A LL ++ P
Sbjct: 375 EGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILH--YYPLEEVLTAEYLLEEFRP 432
Query: 473 DLLTQYTDALVPENSRVTLISRSLE--TDSAEKWYGTAYKVVDYPADLIKNMKSPGLNPA 530
DL+ D L PEN RV ++S+S E TD E+WYGT YK P ++IK ++ LN
Sbjct: 433 DLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGK 492
Query: 531 LTLPRPNEFVSTNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKL 590
LP NEF+ TNF++ ++ + P L+ +SKLW+K+DD+F+ P+ + F
Sbjct: 493 FKLPTKNEFIPTNFEILPLE-KEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFS 551
Query: 591 PHTHASIINSMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLII 650
P + ++ ++ LY +L D+L + Y A A L T G+ ++ G+N+K I
Sbjct: 552 PFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPI 611
Query: 651 LLTRFLQGVNSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEK 710
LL + ++ + +FE + RFEI+K+ +R L N E P+ Y ++ E +W+ E
Sbjct: 612 LLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDEL 671
Query: 711 LQVFEKLTFEQLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIHN---LQ 767
+ + +T +L FIP + ++ E L+HGNI + AL + +++ + + H L
Sbjct: 672 KEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLP 731
Query: 768 VSNNRLRSYLLPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFAQLIHEP 827
R R LP F Y+ ++ + N I+ Q D+ S + LF Q+I EP
Sbjct: 732 SQLVRYREVQLPDRGWFVYQQ--RNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEP 789
Query: 828 CFDTLRTKEQLGYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVLRDMP 887
CF+TLRTKEQLGY+VFS +G +R +IQSE YLE R+ F T + + DM
Sbjct: 790 CFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMT 849
Query: 888 EEDFEKHKEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMID 947
EE F+KH +AL L K K ++ E A+Y I YNF + + +TK+ +I
Sbjct: 850 EEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIK 909
Query: 948 FYENYIM--SENASKLILHLKSQ------VENKELNENELDTAK---YPTGQLIEDVGAF 996
FY+ + + K+ +H+ ++ V + +N+++ ++ P ++I+++ F
Sbjct: 910 FYKEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEF 969
Query: 997 KSTLFVAPVRQPMKDF 1012
K L + P+ +P +F
Sbjct: 970 KRGLPLFPLVKPHINF 985
>ref|NP_112419.2| insulin degrading enzyme [Mus musculus]
gb|AAH41675.1| Insulin degrading enzyme [Mus musculus]
Length = 1019
Score = 1131 bits (2927), Expect = 0.0, Method: Composition-based stats.
Identities = 373/986 (37%), Positives = 577/986 (58%), Gaps = 22/986 (2%)
Query: 44 RYYTTNPYNMTSNFKTFNLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVN 103
T + +K D+R YR +EL N +K LLI DP DK++A+LDV+
Sbjct: 34 FPKQTYSTMSNPAIQRIEDQIVKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVH 93
Query: 104 IGAFEDPKNLPGLAHFCEHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEV 163
IG+ DP N+PGL+HFCEH+LF+G++K+P ENEYS +LS+H GSSNA+T+ ++TNY+F+V
Sbjct: 94 IGSLSDPPNIPGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDV 153
Query: 164 NHQHLFGALDRFSGFFSCPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKH 223
+H+HL GALDRF+ FF CPLF+ D+E+NAV+SE++KN+ ND WR++QL+K+ N KH
Sbjct: 154 SHEHLEGALDRFAQFFLCPLFDASCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKH 213
Query: 224 PYHKFSTGNIETLGTLPKENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYD 283
P+ KF TGN TL T P + G++VR+ELLKFH +YS+NLM +C+LGRE LD L++
Sbjct: 214 PFSKFGTGNKYTLETRPNQEGIDVREELLKFHSTYYSSNLMAICVLGRESLDDLTNLVVK 273
Query: 284 LFKDVANNGREVPLYAEPIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRI 343
LF +V N +P + E Q EHL+++ ++ P+KD++ L ++F +PD++++++S P
Sbjct: 274 LFSEVENKNVPLPEFPEHPFQEEHLRQLYKIVPIKDIRNLYVTFPIPDLQQYYKSNPGHY 333
Query: 344 LSHLIGHEGSGSLLAHLKKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVL 403
L HLIGHEG GSLL+ LK GW N L G ++G FF +++DLT+ GL H D+I+
Sbjct: 334 LGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILH 393
Query: 404 IFQYIEMLKNSLPQKWIFNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVS-RIL 462
+FQYI+ L+ PQ+W+F E +D++ F+FK P S +A L Y P++ +
Sbjct: 394 MFQYIQKLRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGKLH--YYPLNGVLT 451
Query: 463 AMGLLTKYEPDLLTQYTDALVPENSRVTLISRSLE--TDSAEKWYGTAYKVVDYPADLIK 520
A LL ++ PDL+ D L PEN RV ++S+S E TD E+WYGT YK P D+I+
Sbjct: 452 AEYLLEEFRPDLIDMVLDKLRPENVRVAIVSKSFEGKTDRTEQWYGTQYKQEAIPEDIIQ 511
Query: 521 NMKSPGLNPALTLPRPNEFVSTNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQP 580
++ LN LP NEF+ TNF++ ++ P L+ +SKLW+K+DD+F+ P
Sbjct: 512 KWQNADLNGKFKLPTKNEFIPTNFEILSLE-KDATPYPALIKDTAMSKLWFKQDDKFFLP 570
Query: 581 RGYIYLSFKLPHTHASIINSMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAIT 640
+ + F P + ++ ++ LY +L D+L + Y A A L T G+ ++
Sbjct: 571 KACLNFEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLS 630
Query: 641 ASGFNEKLIILLTRFLQGVNSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAII 700
G+N+K ILL + + + +FE K RFEI+K+ +R L N E P+ Y ++
Sbjct: 631 VKGYNDKQPILLKKITEKMATFEIDKKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLM 690
Query: 701 NERSWSTAEKLQVFEKLTFEQLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIP 760
E +W+ E + + +T +L FIP + ++ E L+HGNI + AL V +++ +
Sbjct: 691 TEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGVMQMVEDTLI 750
Query: 761 NNIHN---LQVSNNRLRSYLLPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALS 817
+ H L R R LP F Y+ ++ + N I+ Q D+ S +
Sbjct: 751 EHAHTKPLLPSQLVRYREVQLPDRGWFVYQQ--RNEVHNNCGIEIYYQTDMQSTSENMFL 808
Query: 818 GLFAQLIHEPCFDTLRTKEQLGYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYE 877
LF Q+I EPCF+TLRTKEQLGY+VFS +G +R +IQSE YLE R+ F
Sbjct: 809 ELFCQIISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLI 868
Query: 878 TFGQVLRDMPEEDFEKHKEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLV 937
T + + DM EE F+KH +AL L K K ++ E A+Y I YN+ + +
Sbjct: 869 TMEKAIEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNYDRDNIEVAYL 928
Query: 938 ANITKQQMIDFYENYIM--SENASKLILHLKSQ------VENKELNENELDTA---KYPT 986
+TK +I FY+ + + K+ +H+ ++ V + ++N+++ + P
Sbjct: 929 KTLTKDDIIRFYQEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPSQNDINLSEAPPLPQ 988
Query: 987 GQLIEDVGAFKSTLFVAPVRQPMKDF 1012
++I ++ FK L + P+ +P +F
Sbjct: 989 PEVIHNMTEFKRGLPLFPLVKPHINF 1014
>ref|XP_001090137.1| PREDICTED: insulysin isoform 2 [Macaca mulatta]
Length = 978
Score = 1131 bits (2927), Expect = 0.0, Method: Composition-based stats.
Identities = 371/976 (38%), Positives = 578/976 (59%), Gaps = 22/976 (2%)
Query: 54 TSNFKTFNLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNL 113
K K D+R YR +EL N +K LLI DP DK++A+LDV+IG+ DP N+
Sbjct: 3 NPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNI 62
Query: 114 PGLAHFCEHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGALD 173
GL+HFCEH+LF+G++K+P ENEYS +LS+H GSSNA+T+ ++TNY+F+V+H+HL GALD
Sbjct: 63 AGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALD 122
Query: 174 RFSGFFSCPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNI 233
RF+ FF CPLF++ D+E+NAV+SE++KN+ ND WR++QL+K+ N KHP+ KF TGN
Sbjct: 123 RFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNK 182
Query: 234 ETLGTLPKENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGR 293
TL T P + G++VR ELLKFH +YS+NLM +C+LGRE LD L++ LF +V N
Sbjct: 183 YTLETRPNQEGIDVRQELLKFHSTYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKSV 242
Query: 294 EVPLYAEPIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGS 353
+P + E Q EHL+++ ++ P+KD++ L ++F +PD++++++S P L HLIGHEG
Sbjct: 243 PLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGP 302
Query: 354 GSLLAHLKKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKN 413
GSLL+ LK GW N L G ++G FF +++DLT+ GL H D+I+ +FQYI+ L+
Sbjct: 303 GSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRA 362
Query: 414 SLPQKWIFNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRIL-AMGLLTKYEP 472
PQ+W+F E +D++ F+FK P S +A L Y P+ +L A LL ++ P
Sbjct: 363 EGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILH--YYPLEEVLTAEYLLEEFRP 420
Query: 473 DLLTQYTDALVPENSRVTLISRSLE--TDSAEKWYGTAYKVVDYPADLIKNMKSPGLNPA 530
DL+ D L PEN RV ++S+S E TD E+WYGT YK P ++IK ++ LN
Sbjct: 421 DLIEMVLDKLRPENVRVAVVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGK 480
Query: 531 LTLPRPNEFVSTNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKL 590
LP NEF+ TNF++ ++ + P L+ +SKLW+K+DD+F+ P+ + F
Sbjct: 481 FKLPTKNEFIPTNFEILPLE-KEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFS 539
Query: 591 PHTHASIINSMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLII 650
P + ++ ++ LY +L D+L + Y A A L T G+ ++ G+N+K I
Sbjct: 540 PFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPI 599
Query: 651 LLTRFLQGVNSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEK 710
LL + ++ + +FE + RFEI+K+ +R L N E P+ Y ++ E +W+ E
Sbjct: 600 LLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDEL 659
Query: 711 LQVFEKLTFEQLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIHN---LQ 767
+ + +T +L FIP + ++ E L+HGNI + AL + +++ + + H L
Sbjct: 660 KEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLP 719
Query: 768 VSNNRLRSYLLPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFAQLIHEP 827
R R LP F Y+ ++ + N I+ Q D+ S + LF Q+I EP
Sbjct: 720 SQLVRYREVQLPDRGWFVYQQ--RNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEP 777
Query: 828 CFDTLRTKEQLGYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVLRDMP 887
CF+TLRTKEQLGY+VFS +G +R +IQSE YLE R+ F T + + DM
Sbjct: 778 CFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMT 837
Query: 888 EEDFEKHKEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMID 947
EE F+KH +AL L K K ++ E A+Y I Y+F + + +TK+ +I
Sbjct: 838 EEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYHFDRDNTEVAYLKTLTKEDIIK 897
Query: 948 FYENYIM--SENASKLILHLKSQ------VENKELNENELDTAK---YPTGQLIEDVGAF 996
FY+ + + K+ +H+ ++ V + +N+++ ++ P ++I+++ F
Sbjct: 898 FYKEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEF 957
Query: 997 KSTLFVAPVRQPMKDF 1012
K L + P+ +P +F
Sbjct: 958 KRGLPLFPLVKPHINF 973
>pdb|2JG4|A Chain A, Substrate-Free Ide Structure In Its Closed Conformation
pdb|2JG4|B Chain B, Substrate-Free Ide Structure In Its Closed Conformation
Length = 990
Score = 1131 bits (2927), Expect = 0.0, Method: Composition-based stats.
Identities = 371/976 (38%), Positives = 578/976 (59%), Gaps = 22/976 (2%)
Query: 54 TSNFKTFNLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNL 113
K K D+R YR +EL N +K LLI DP DK++A+LDV+IG+ DP N+
Sbjct: 15 NPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNI 74
Query: 114 PGLAHFCEHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGALD 173
GL+HFCEH+LF+G++K+P ENEYS +LS+H GSSNA+T+ ++TNY+F+V+H+HL GALD
Sbjct: 75 AGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALD 134
Query: 174 RFSGFFSCPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNI 233
RF+ FF CPLF++ D+E+NAV+SE++KN+ ND WR++QL+K+ N KHP+ KF TGN
Sbjct: 135 RFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNK 194
Query: 234 ETLGTLPKENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGR 293
TL T P + G++VR ELLKFH +YS+NLM +C+LGRE LD L++ LF +V N
Sbjct: 195 YTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNV 254
Query: 294 EVPLYAEPIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGS 353
+P + E Q EHL+++ ++ P+KD++ L ++F +PD++++++S P L HLIGHEG
Sbjct: 255 PLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGP 314
Query: 354 GSLLAHLKKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKN 413
GSLL+ LK GW N L G ++G FF +++DLT+ GL H D+I+ +FQYI+ L+
Sbjct: 315 GSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRA 374
Query: 414 SLPQKWIFNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRIL-AMGLLTKYEP 472
PQ+W+F E +D++ F+FK P S +A L Y P+ +L A LL ++ P
Sbjct: 375 EGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILH--YYPLEEVLTAEYLLEEFRP 432
Query: 473 DLLTQYTDALVPENSRVTLISRSLE--TDSAEKWYGTAYKVVDYPADLIKNMKSPGLNPA 530
DL+ D L PEN RV ++S+S E TD E+WYGT YK P ++IK ++ LN
Sbjct: 433 DLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGK 492
Query: 531 LTLPRPNEFVSTNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKL 590
LP NEF+ TNF++ ++ + P L+ +SKLW+K+DD+F+ P+ + F
Sbjct: 493 FKLPTKNEFIPTNFEILPLE-KEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFS 551
Query: 591 PHTHASIINSMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLII 650
P + ++ ++ LY +L D+L + Y A A L T G+ ++ G+N+K I
Sbjct: 552 PFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPI 611
Query: 651 LLTRFLQGVNSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEK 710
LL + ++ + +FE + RFEI+K+ +R L N E P+ Y ++ E +W+ E
Sbjct: 612 LLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDEL 671
Query: 711 LQVFEKLTFEQLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIHN---LQ 767
+ + +T +L FIP + ++ E L+HGNI + AL + +++ + + H L
Sbjct: 672 KEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLP 731
Query: 768 VSNNRLRSYLLPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFAQLIHEP 827
R R LP F Y+ ++ + N I+ Q D+ S + LF Q+I EP
Sbjct: 732 SQLVRYREVQLPDRGWFVYQQ--RNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEP 789
Query: 828 CFDTLRTKEQLGYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVLRDMP 887
CF+TLRTKEQLG++VFS +G +R +IQSE YLE R+ F T + + DM
Sbjct: 790 CFNTLRTKEQLGFIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMT 849
Query: 888 EEDFEKHKEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMID 947
EE F+KH +AL L K K ++ E A+Y I YNF + + +TK+ +I
Sbjct: 850 EEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIK 909
Query: 948 FYENYIM--SENASKLILHLKSQ------VENKELNENELDTAK---YPTGQLIEDVGAF 996
FY+ + + K+ +H+ ++ V + +N+++ ++ P ++I+++ F
Sbjct: 910 FYKEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEF 969
Query: 997 KSTLFVAPVRQPMKDF 1012
K L + P+ +P +F
Sbjct: 970 KRGLPLFPLVKPHINF 985
>ref|NP_001069317.1| insulin-degrading enzyme [Bos taurus]
sp|Q24K02|IDE_BOVIN Insulin-degrading enzyme (Insulysin) (Insulinase) (Insulin protease)
gb|AAI14106.1| Similar to Insulin-degrading enzyme (Insulysin) (Insulinase) (Insulin
protease) [Bos taurus]
Length = 1019
Score = 1131 bits (2925), Expect = 0.0, Method: Composition-based stats.
Identities = 372/982 (37%), Positives = 580/982 (59%), Gaps = 22/982 (2%)
Query: 48 TNPYNMTSNFKTFNLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAF 107
T K +K D+R YR +EL N +K LL+ DP DK++A+LDV+IG+
Sbjct: 38 TYSKMNNPAIKRIGHHIIKSHEDKREYRGLELANGIKVLLVSDPTTDKSSAALDVHIGSL 97
Query: 108 EDPKNLPGLAHFCEHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQH 167
DP N+ GL+HFCEH+LF+G++K+P ENEYS +LS+H GSSNA+T+ ++TNY+F+V+H+H
Sbjct: 98 SDPPNIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEH 157
Query: 168 LFGALDRFSGFFSCPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHK 227
L GALDRF+ FF CPLF++ D+E+NAV+SE++KN+ ND WR++QL+K+ N KHP+ K
Sbjct: 158 LEGALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSK 217
Query: 228 FSTGNIETLGTLPKENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKD 287
F TGN TL T P + G++VR ELLKFH +YS+NLM +C+LGRE LD L++ LF +
Sbjct: 218 FGTGNKYTLETRPNQEGIDVRQELLKFHSTYYSSNLMAICVLGRESLDDLTNLVVKLFSE 277
Query: 288 VANNGREVPLYAEPIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHL 347
V N +P + E Q EHL+++ ++ P+KD++ L ++F +PD++++++S P L HL
Sbjct: 278 VENKNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHL 337
Query: 348 IGHEGSGSLLAHLKKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQY 407
IGHEG GSLL+ LK GW N L G ++G FF +++DLT+ GL H D+I+ +FQY
Sbjct: 338 IGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQY 397
Query: 408 IEMLKNSLPQKWIFNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRIL-AMGL 466
I+ L+ PQ+W+F E +D++ F+FK P S +A L Y P+ +L A L
Sbjct: 398 IQKLRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILH--YYPLEEVLTAEYL 455
Query: 467 LTKYEPDLLTQYTDALVPENSRVTLISRSLE--TDSAEKWYGTAYKVVDYPADLIKNMKS 524
L ++ PDL+ D L PEN RV ++S+S E TD E+WYGT YK P ++IK ++
Sbjct: 456 LEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQN 515
Query: 525 PGLNPALTLPRPNEFVSTNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYI 584
LN LP NEF+ TNF++ ++ + P L+ +SKLW+K+DD+F+ P+ +
Sbjct: 516 ADLNGKFKLPMKNEFIPTNFEILSLE-KEATPYPSLIKDTAMSKLWFKQDDKFFLPKACL 574
Query: 585 YLSFKLPHTHASIINSMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGF 644
F P + ++ ++ LY +L D+L + Y A A L T G+ ++ G+
Sbjct: 575 NFEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGY 634
Query: 645 NEKLIILLTRFLQGVNSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERS 704
N+K ILL + ++ + +FE + RFEI+K+ +R L N E P+ Y ++ E +
Sbjct: 635 NDKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVA 694
Query: 705 WSTAEKLQVFEKLTFEQLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIH 764
W+ E + + +T +L FIP + ++ E L+HGNI + AL + +++ + + H
Sbjct: 695 WTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAH 754
Query: 765 N---LQVSNNRLRSYLLPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFA 821
L R R LP F Y+ ++ + N I+ Q D+ S + LF
Sbjct: 755 TKPLLPSQLVRYREVQLPDRGWFVYQQ--RNEVHNNCGIEIYYQTDMQSTSENMFLELFC 812
Query: 822 QLIHEPCFDTLRTKEQLGYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQ 881
Q+I EPCF+TLRTKEQLGY+VFS +G +R +IQSE YLE R+ F T +
Sbjct: 813 QIISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEK 872
Query: 882 VLRDMPEEDFEKHKEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANIT 941
+ DM EE F+KH +AL L K K ++ E A+Y I YNF + + +T
Sbjct: 873 SIEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNIEVAYLKTLT 932
Query: 942 KQQMIDFYENYIM--SENASKLILHLKSQ------VENKELNENELDTAK---YPTGQLI 990
K+ +I FY+ + + K+ +H+ ++ V + +N+++ ++ P ++I
Sbjct: 933 KEDIIKFYKEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVI 992
Query: 991 EDVGAFKSTLFVAPVRQPMKDF 1012
+++ FK L + P+ +P +F
Sbjct: 993 QNMTEFKRGLPLFPLVKPHINF 1014
>ref|NP_037291.1| insulin degrading enzyme [Rattus norvegicus]
sp|P35559|IDE_RAT Insulin-degrading enzyme (Insulysin) (Insulinase) (Insulin protease)
emb|CAA47689.1| insulin-degrading enzyme [Rattus norvegicus]
gb|EDM13196.1| insulin degrading enzyme [Rattus norvegicus]
Length = 1019
Score = 1127 bits (2916), Expect = 0.0, Method: Composition-based stats.
Identities = 371/976 (38%), Positives = 576/976 (59%), Gaps = 22/976 (2%)
Query: 54 TSNFKTFNLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNL 113
+ +K D+R YR +EL N +K LLI DP DK++A+LDV+IG+ DP N+
Sbjct: 44 NPAIQRIEDHIVKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNI 103
Query: 114 PGLAHFCEHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGALD 173
PGL+HFCEH+LF+G++K+P ENEYS +LS+H GSSNA+T+ ++TNY+F+V+H+HL GALD
Sbjct: 104 PGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALD 163
Query: 174 RFSGFFSCPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNI 233
RF+ FF CPLF+ D+E+NAV+SE++KN+ ND WR++QL+K+ N KHP+ KF TGN
Sbjct: 164 RFAQFFLCPLFDASCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNK 223
Query: 234 ETLGTLPKENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGR 293
TL T P + G++VR+ELLKFH +YS+NLM +C+LGRE LD L++ LF +V N
Sbjct: 224 YTLETRPNQEGIDVREELLKFHSTYYSSNLMAICVLGRESLDDLTNLVVKLFSEVENKNV 283
Query: 294 EVPLYAEPIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGS 353
+P + E Q EHL+++ ++ P+KD++ L ++F +PD++++++S P L HLIGHEG
Sbjct: 284 PLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQQYYKSNPGHYLGHLIGHEGP 343
Query: 354 GSLLAHLKKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKN 413
GSLL+ LK GW N L G ++G FF +++DLT+ GL H D+I+ +FQYI+ L+
Sbjct: 344 GSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRA 403
Query: 414 SLPQKWIFNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVS-RILAMGLLTKYEP 472
PQ+W+F E +D++ F+FK P S +A L Y P++ + A LL ++ P
Sbjct: 404 EGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGKLH--YYPLNGVLTAEYLLEEFRP 461
Query: 473 DLLTQYTDALVPENSRVTLISRSLE--TDSAEKWYGTAYKVVDYPADLIKNMKSPGLNPA 530
DL+ D L PEN RV ++S+S E TD E+WYGT YK P D+I+ ++ LN
Sbjct: 462 DLIDMVLDKLRPENVRVAIVSKSFEGKTDRTEQWYGTQYKQEAIPEDVIQKWQNADLNGK 521
Query: 531 LTLPRPNEFVSTNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKL 590
LP NEF+ TNF++ ++ P L+ +SKLW+K+DD+F+ P+ + F
Sbjct: 522 FKLPTKNEFIPTNFEILALE-KDATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFS 580
Query: 591 PHTHASIINSMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLII 650
P + ++ ++ LY +L D+L + Y A A L T G+ ++ G+N+K I
Sbjct: 581 PFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPI 640
Query: 651 LLTRFLQGVNSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEK 710
LL + + + +FE K RFEI+K+ +R L N E P+ Y ++ E +W+ E
Sbjct: 641 LLKKITEKMATFEIDKKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDEL 700
Query: 711 LQVFEKLTFEQLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIHN---LQ 767
+ + +T +L FIP + ++ E L+HGNI + AL V +++ + + H L
Sbjct: 701 KEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGVMQMVEDTLIEHAHTKPLLP 760
Query: 768 VSNNRLRSYLLPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFAQLIHEP 827
R R LP F Y+ ++ + N I+ Q D+ S + LF Q+I EP
Sbjct: 761 SQLVRYREVQLPDRGWFVYQR--RNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEP 818
Query: 828 CFDTLRTKEQLGYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVLRDMP 887
CF+TLRTKEQLGY+VFS +G +R +IQSE YLE R+ F T + + DM
Sbjct: 819 CFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKAIEDMT 878
Query: 888 EEDFEKHKEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMID 947
EE F+KH +AL L K K ++ E A+Y I YN+ + + ++K +I
Sbjct: 879 EEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNYDRDNIEVAYLKTLSKDDIIK 938
Query: 948 FYENYIM--SENASKLILHLKSQ------VENKELNENELDTA---KYPTGQLIEDVGAF 996
FY+ + + K+ +H+ ++ V + ++N+++ + P ++I ++ F
Sbjct: 939 FYKEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPSQNDINLSEAPPLPQPEVIHNMTEF 998
Query: 997 KSTLFVAPVRQPMKDF 1012
K L + P+ +P +F
Sbjct: 999 KRGLPLFPLVKPHINF 1014
>sp|Q9JHR7|IDE_MOUSE Insulin-degrading enzyme (Insulysin) (Insulinase) (Insulin protease)
emb|CAC01233.1| insulin degrading enzyme [Mus musculus]
Length = 1019
Score = 1123 bits (2906), Expect = 0.0, Method: Composition-based stats.
Identities = 371/986 (37%), Positives = 575/986 (58%), Gaps = 22/986 (2%)
Query: 44 RYYTTNPYNMTSNFKTFNLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVN 103
T + +K D+R YR +EL N +K LLI DP DK++A+LDV+
Sbjct: 34 FPKQTYSTMSNPAIQRIEDQIVKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVH 93
Query: 104 IGAFEDPKNLPGLAHFCEHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEV 163
IG+ DP N+PGL+HFCEH+LF+G++K+P ENEYS +LS+H GSSNA+T+ ++TNY+F+V
Sbjct: 94 IGSLSDPPNIPGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDV 153
Query: 164 NHQHLFGALDRFSGFFSCPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKH 223
+H+HL GALDRF+ FF CPL + D+E+NAV+SE++KN+ ND WR++QL+K+ N KH
Sbjct: 154 SHEHLEGALDRFAQFFLCPLLDASCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKH 213
Query: 224 PYHKFSTGNIETLGTLPKENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYD 283
P+ KF TGN TL T P + G++VR+ELLKFH +YS+NLM +C+LGRE LD L++
Sbjct: 214 PFSKFGTGNKYTLETRPNQEGIDVREELLKFHSTYYSSNLMAICVLGRESLDDLTNLVVK 273
Query: 284 LFKDVANNGREVPLYAEPIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRI 343
LF +V N +P + E Q EHL+++ ++ P+KD++ L ++F +PD++++++S P
Sbjct: 274 LFSEVENKNVPLPEFPEHPFQEEHLRQLYKIVPIKDIRNLYVTFPIPDLQQYYKSNPGYY 333
Query: 344 LSHLIGHEGSGSLLAHLKKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVL 403
L HLIGHEG GSLL+ LK GW N L G ++G FF +++DLT+ GL H D+I+
Sbjct: 334 LGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILH 393
Query: 404 IFQYIEMLKNSLPQKWIFNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVS-RIL 462
+FQYI+ L+ PQ+W+F E +D++ F+FK P S +A L Y P++ +
Sbjct: 394 MFQYIQKLRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGKLH--YYPLNGVLT 451
Query: 463 AMGLLTKYEPDLLTQYTDALVPENSRVTLISRSLE--TDSAEKWYGTAYKVVDYPADLIK 520
A LL ++ PDL+ D L PEN RV ++S+S E TD E+WYGT YK P D+I+
Sbjct: 452 AEYLLEEFRPDLIDMVLDKLRPENVRVAIVSKSFEGKTDRTEQWYGTQYKQEAIPEDVIQ 511
Query: 521 NMKSPGLNPALTLPRPNEFVSTNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQP 580
++ LN LP NEF+ TNF++ ++ P L+ +SKLW+K+DD+F+ P
Sbjct: 512 KWQNADLNGKFKLPTKNEFIPTNFEILSLE-KDATPYPALIKDTAMSKLWFKQDDKFFLP 570
Query: 581 RGYIYLSFKLPHTHASIINSMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAIT 640
+ + F P + ++ ++ LY +L D+L + Y A A L T G+ ++
Sbjct: 571 KACLNFEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLS 630
Query: 641 ASGFNEKLIILLTRFLQGVNSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAII 700
+N+K ILL + + + +FE K RFEI+K+ +R L N E P+ Y ++
Sbjct: 631 VKRYNDKQPILLKKITEKMATFEIDKKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLM 690
Query: 701 NERSWSTAEKLQVFEKLTFEQLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIP 760
E +W+ E + + +T +L FIP + ++ E L+HGNI + AL V +++ +
Sbjct: 691 TEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGVMQMVEDTLI 750
Query: 761 NNIHN---LQVSNNRLRSYLLPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALS 817
+ H L R R LP F Y+ ++ + N I+ Q D+ S +
Sbjct: 751 EHAHTKPLLPSQLVRYREVQLPDRGWFVYQQ--RNEVHNNCGIEIYYQTDMQSTSENMFL 808
Query: 818 GLFAQLIHEPCFDTLRTKEQLGYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYE 877
LF Q+I EPCF+TLRTKEQLGY+VFS +G +R +IQSE YLE R+ F
Sbjct: 809 ELFCQIISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLI 868
Query: 878 TFGQVLRDMPEEDFEKHKEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLV 937
T + + DM EE F+KH +AL L K K ++ E A+Y I YN+ + +
Sbjct: 869 TMEKAIEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNYDRDNIEVAYL 928
Query: 938 ANITKQQMIDFYENYIM--SENASKLILHLKSQ------VENKELNENELDTA---KYPT 986
+TK +I FY+ + + K+ +H+ ++ V + ++N+++ + P
Sbjct: 929 KTLTKDDIIRFYQEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPSQNDINLSEAPPLPQ 988
Query: 987 GQLIEDVGAFKSTLFVAPVRQPMKDF 1012
++I ++ FK L + P+ +P +F
Sbjct: 989 PEVIHNMTEFKRGLPLFPLVKPHINF 1014
>gb|EDL41785.1| insulin degrading enzyme [Mus musculus]
Length = 978
Score = 1123 bits (2905), Expect = 0.0, Method: Composition-based stats.
Identities = 372/976 (38%), Positives = 576/976 (59%), Gaps = 22/976 (2%)
Query: 54 TSNFKTFNLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNL 113
+ +K D+R YR +EL N +K LLI DP DK++A+LDV+IG+ DP N+
Sbjct: 3 NPAIQRIEDQIVKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNI 62
Query: 114 PGLAHFCEHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGALD 173
PGL+HFCEH+LF+G++K+P ENEYS +LS+H GSSNA+T+ ++TNY+F+V+H+HL GALD
Sbjct: 63 PGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALD 122
Query: 174 RFSGFFSCPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNI 233
RF+ FF CPLF+ D+E+NAV+SE++KN+ ND WR++QL+K+ N KHP+ KF TGN
Sbjct: 123 RFAQFFLCPLFDASCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNK 182
Query: 234 ETLGTLPKENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGR 293
TL T P + G++VR+ELLKFH +YS+NLM +C+LGRE LD L++ LF +V N
Sbjct: 183 YTLETRPNQEGIDVREELLKFHSTYYSSNLMAICVLGRESLDDLTNLVVKLFSEVENKNV 242
Query: 294 EVPLYAEPIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGS 353
+P + E Q EHL+++ ++ P+KD++ L ++F +PD++++++S P L HLIGHEG
Sbjct: 243 PLPEFPEHPFQEEHLRQLYKIVPIKDIRNLYVTFPIPDLQQYYKSNPGHYLGHLIGHEGP 302
Query: 354 GSLLAHLKKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKN 413
GSLL+ LK GW N L G ++G FF +++DLT+ GL H D+I+ +FQYI+ L+
Sbjct: 303 GSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRA 362
Query: 414 SLPQKWIFNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVS-RILAMGLLTKYEP 472
PQ+W+F E +D++ F+FK P S +A L Y P++ + A LL ++ P
Sbjct: 363 EGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGKLH--YYPLNGVLTAEYLLEEFRP 420
Query: 473 DLLTQYTDALVPENSRVTLISRSLE--TDSAEKWYGTAYKVVDYPADLIKNMKSPGLNPA 530
DL+ D L PEN RV ++S+S E TD E+WYGT YK P D+I+ ++ LN
Sbjct: 421 DLIDMVLDKLRPENVRVAIVSKSFEGKTDRTEQWYGTQYKQEAIPEDIIQKWQNADLNGK 480
Query: 531 LTLPRPNEFVSTNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKL 590
LP NEF+ TNF++ ++ P L+ +SKLW+K+DD+F+ P+ + F
Sbjct: 481 FKLPTKNEFIPTNFEILSLE-KDATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFS 539
Query: 591 PHTHASIINSMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLII 650
P + ++ ++ LY +L D+L + Y A A L T G+ ++ G+N+K I
Sbjct: 540 PFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPI 599
Query: 651 LLTRFLQGVNSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEK 710
LL + + + +FE K RFEI+K+ +R L N E P+ Y ++ E +W+ E
Sbjct: 600 LLKKITEKMATFEIDKKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDEL 659
Query: 711 LQVFEKLTFEQLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIHN---LQ 767
+ + +T +L FIP + ++ E L+HGNI + AL V +++ + + H L
Sbjct: 660 KEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGVMQMVEDTLIEHAHTKPLLP 719
Query: 768 VSNNRLRSYLLPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFAQLIHEP 827
R R LP F Y+ ++ + N I+ Q D+ S + LF Q+I EP
Sbjct: 720 SQLVRYREVQLPDRGWFVYQQ--RNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEP 777
Query: 828 CFDTLRTKEQLGYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVLRDMP 887
CF+TLRTKEQLGY+VFS +G +R +IQSE YLE R+ F T + + DM
Sbjct: 778 CFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKAIEDMT 837
Query: 888 EEDFEKHKEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMID 947
EE F+KH +AL L K K ++ E A+Y I YN+ + + +TK +I
Sbjct: 838 EEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNYDRDNIEVAYLKTLTKDDIIR 897
Query: 948 FYENYIM--SENASKLILHLKSQ------VENKELNENELDTA---KYPTGQLIEDVGAF 996
FY+ + + K+ +H+ ++ V + ++N+++ + P ++I ++ F
Sbjct: 898 FYQEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPSQNDINLSEAPPLPQPEVIHNMTEF 957
Query: 997 KSTLFVAPVRQPMKDF 1012
K L + P+ +P +F
Sbjct: 958 KRGLPLFPLVKPHINF 973
>ref|XP_001146582.1| PREDICTED: insulysin isoform 3 [Pan troglodytes]
Length = 1019
Score = 1121 bits (2901), Expect = 0.0, Method: Composition-based stats.
Identities = 370/982 (37%), Positives = 578/982 (58%), Gaps = 22/982 (2%)
Query: 48 TNPYNMTSNFKTFNLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAF 107
T K K D+R YR +EL N +K LLI DP DK++A+LDV+IG+
Sbjct: 38 TYSKMNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSL 97
Query: 108 EDPKNLPGLAHFCEHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQH 167
DP N+ GL+HFCEH+LF+G++K+P ENEYS +LS+H GSSNA+T+ ++TNY+F+V+H+H
Sbjct: 98 SDPPNIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEH 157
Query: 168 LFGALDRFSGFFSCPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHK 227
L GALDRF+ FF CPLF++ D+E+NAV+SE++KN+ ND WR++QL+K+ N KHP+ K
Sbjct: 158 LEGALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSK 217
Query: 228 FSTGNIETLGTLPKENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKD 287
F TGN TL T P + G++VR ELLKFH +YS+NLM +C+LGRE LD L++ LF +
Sbjct: 218 FGTGNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSE 277
Query: 288 VANNGREVPLYAEPIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHL 347
V N +P + E Q EHL+++ ++ P+KD++ L ++F +PD++++++S P L HL
Sbjct: 278 VENKNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHL 337
Query: 348 IGHEGSGSLLAHLKKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQY 407
IGHEG GSLL+ LK GW N L G ++G FF +++DLT+ GL H D+I+ +FQY
Sbjct: 338 IGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQY 397
Query: 408 IEMLKNSLPQKWIFNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRIL-AMGL 466
I+ L+ PQ+W+F E +D++ F+FK P S +A L Y P+ +L A L
Sbjct: 398 IQKLRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILH--YYPLEEVLTAEYL 455
Query: 467 LTKYEPDLLTQYTDALVPENSRVTLISRSLE--TDSAEKWYGTAYKVVDYPADLIKNMKS 524
L ++ PDL+ D L PEN RV ++S+S E TD E+WYGT YK P ++IK ++
Sbjct: 456 LEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQN 515
Query: 525 PGLNPALTLPRPNEFVSTNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYI 584
LN LP NEF+ TNF++ ++ + P L+ +SKLW+K+DD+F+ P+ +
Sbjct: 516 ADLNGKFKLPTKNEFIPTNFEILPLE-KEATPYPALIKDTAMSKLWFKQDDKFFLPKACL 574
Query: 585 YLSFKLPHTHASIINSMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGF 644
F + +A ++ ++ L+ +L D LK+ Y A + L + ++ G+
Sbjct: 575 NFEFFSRYIYADPLHCNMTYLFIRLLKDDLKEYTYAARLSGLSYGIASGMNAILLSVKGY 634
Query: 645 NEKLIILLTRFLQGVNSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERS 704
N+K ILL + ++ + +FE + RFEI+K+ +R L N E P+ Y ++ E +
Sbjct: 635 NDKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVA 694
Query: 705 WSTAEKLQVFEKLTFEQLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIH 764
W+ E + + +T +L FIP + ++ E L+HGNI + AL + +++ + + H
Sbjct: 695 WTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAH 754
Query: 765 N---LQVSNNRLRSYLLPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFA 821
L R R LP F Y+ ++ + N I+ Q D+ S + LF
Sbjct: 755 TKPLLPSQLVRYREVQLPDRGWFVYQQ--RNEVHNNCGIEIYYQTDMQSTSENMFLELFC 812
Query: 822 QLIHEPCFDTLRTKEQLGYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQ 881
Q+I EPCF+TLRTKEQLGY+VFS +G +R +IQSE YLE R+ F T +
Sbjct: 813 QIISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEK 872
Query: 882 VLRDMPEEDFEKHKEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANIT 941
+ DM EE F+KH +AL L K K ++ E A+Y I YNF + + +T
Sbjct: 873 SIEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLT 932
Query: 942 KQQMIDFYENYIM--SENASKLILHLKSQ------VENKELNENELDTAK---YPTGQLI 990
K+ +I FY+ + + K+ +H+ ++ V + +N+++ ++ P ++I
Sbjct: 933 KEDIIKFYKEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVI 992
Query: 991 EDVGAFKSTLFVAPVRQPMKDF 1012
+++ FK L + P+ +P +F
Sbjct: 993 QNMTEFKRGLPLFPLVKPHINF 1014
>dbj|BAF62161.1| insulin-degrading enzyme [Danio rerio]
Length = 998
Score = 1121 bits (2901), Expect = 0.0, Method: Composition-based stats.
Identities = 375/975 (38%), Positives = 577/975 (59%), Gaps = 22/975 (2%)
Query: 55 SNFKTFNLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNLP 114
K D ++ D+R YR +E N LKA+LI DP DK++A+LDV++G+ DP+N+
Sbjct: 24 PAVKRVVSDIIRSPEDKREYRGLESTNGLKAILISDPTTDKSSAALDVHMGSLSDPENIS 83
Query: 115 GLAHFCEHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGALDR 174
GLAHFCEH+LF+G+EK+P ENEYS +LS+H GSSNA+T+ ++TNY+F+V+H+HL GALDR
Sbjct: 84 GLAHFCEHMLFLGTEKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLQGALDR 143
Query: 175 FSGFFSCPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIE 234
F+ FF CPLF++ D+E+NAV+SE++KNL ND WR++QL+K+ N KHP+ KF TGN
Sbjct: 144 FAQFFLCPLFDESCKDREVNAVDSEHEKNLMNDAWRLFQLEKATGNPKHPFSKFGTGNKL 203
Query: 235 TLGTLPKENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGRE 294
TL T P + G+++R+ELLKFH +YS+NLM LC+LGRE LD L+ LF +V N
Sbjct: 204 TLETRPSQQGIDIREELLKFHSTYYSSNLMGLCVLGRETLDELTSMVVKLFGEVENKNVP 263
Query: 295 VPLYAEPIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGSG 354
VP + Q EHL++ +V P+KD++ L ++F +PD++++++S P L HLIGHEG G
Sbjct: 264 VPEFPTHPFQEEHLRQFYKVVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPG 323
Query: 355 SLLAHLKKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNS 414
SLL+ LK GW N L G ++G FF +++DLT+ GL H D+I +FQYI+ L+
Sbjct: 324 SLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIIFHMFQYIQKLRTE 383
Query: 415 LPQKWIFNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILAM-GLLTKYEPD 473
PQ+W+F E +D++ F+FK P S +A L Y P+ ILA LL ++ PD
Sbjct: 384 GPQEWVFQECKDLNTVAFRFKDKERPRGYTSKVAGLLH--YYPLEEILAAEYLLEEFRPD 441
Query: 474 LLTQYTDALVPENSRVTLISRSLE--TDSAEKWYGTAYKVVDYPADLIKNMKSPGLNPAL 531
L+ D L PEN RV ++S+S E TD E+WYGT YK + IK + LN
Sbjct: 442 LIEMVLDKLRPENVRVAVVSKSFEGQTDRTEEWYGTQYKQEAITDEAIKKWDNADLNGKF 501
Query: 532 TLPRPNEFVSTNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLP 591
LP NEF+ TNF++ ++ P P L+ +SK+W+K+DD+F+ P+ + F P
Sbjct: 502 KLPMKNEFIPTNFEIYPLEKDSP-SAPTLIKDTAMSKVWFKQDDKFFLPKACLNFEFFSP 560
Query: 592 HTHASIINSMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLIIL 651
+ ++ ++ LY +L D+L + Y A A L T G+ ++ G+N+K IL
Sbjct: 561 FAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTVYGMYLSVKGYNDKQHIL 620
Query: 652 LTRFLQGVNSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKL 711
L + ++ + +FE + RF+I+K+ +R L N E P+ Y ++ E +W+ E
Sbjct: 621 LKKIIEKMATFEIDEKRFDIIKEAYMRPLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELR 680
Query: 712 QVFEKLTFEQLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIHN---LQV 768
+ +T +L FIP + ++ E L+HGNI + ALE+ +++ + + H L
Sbjct: 681 DALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQSALEMMQMLEDTLIEHAHTKPLLPS 740
Query: 769 SNNRLRSYLLPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFAQLIHEPC 828
R R +P G + Y+ ++ + N I+ Q D+ + + L LF Q+I EPC
Sbjct: 741 QLIRYREVQVPDGGWYVYQQ--RNEVHNNCGIEIYYQTDMQNTHENMLLELFCQIISEPC 798
Query: 829 FDTLRTKEQLGYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVLRDMPE 888
F+TLRTKEQLGY+VFS +G +R +IQSE YLE R+ F +T + + +M +
Sbjct: 799 FNTLRTKEQLGYIVFSGPRRANGVQGLRFIIQSEKAPHYLESRVEAFLKTMEKSVEEMGD 858
Query: 889 EDFEKHKEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMIDF 948
E F+KH +AL L K K +A E A+Y I YNF + + +TK+ ++ F
Sbjct: 859 EAFQKHIQALAIRRLDKPKKLAAECAKYWGEIISQQYNFDRDNIEVAYLKTLTKEHIMQF 918
Query: 949 YEN--YIMSENASKLILHLKSQ------VENKELNENELDTAK---YPTGQLIEDVGAFK 997
Y + I + K+ +H+ S+ + + +N+++ A P L++D+ FK
Sbjct: 919 YRDLLAIDAPRRHKVSVHVLSREMDSCPLVGEFPAQNDVNLAPAPSLPQPSLVQDMTEFK 978
Query: 998 STLFVAPVRQPMKDF 1012
+L + P+ +P +F
Sbjct: 979 RSLPLFPLTKPHINF 993
>ref|NP_001082994.1| insulin-degrading enzyme [Danio rerio]
gb|AAI39608.1| Zgc:162603 protein [Danio rerio]
Length = 978
Score = 1121 bits (2900), Expect = 0.0, Method: Composition-based stats.
Identities = 375/975 (38%), Positives = 577/975 (59%), Gaps = 22/975 (2%)
Query: 55 SNFKTFNLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNLP 114
K D ++ D+R YR +E N LKA+LI DP DK++A+LDV++G+ DP+N+
Sbjct: 4 PAVKRVVSDIIRSPEDKREYRGLEFTNGLKAILISDPTTDKSSAALDVHMGSLSDPENIS 63
Query: 115 GLAHFCEHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGALDR 174
GLAHFCEH+LF+G+EK+P ENEYS +LS+H GSSNA+T+ ++TNY+F+V+H+HL GALDR
Sbjct: 64 GLAHFCEHMLFLGTEKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLQGALDR 123
Query: 175 FSGFFSCPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIE 234
F+ FF CPLF++ D+E+NAV+SE++KNL ND WR++QL+K+ N KHP+ KF TGN
Sbjct: 124 FAQFFLCPLFDESCKDREVNAVDSEHEKNLMNDAWRLFQLEKATGNPKHPFSKFGTGNKL 183
Query: 235 TLGTLPKENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGRE 294
TL T P + G+++R+ELLKFH +YS+NLM LC+LGRE LD L+ LF +V N
Sbjct: 184 TLETRPSQQGIDIREELLKFHSTYYSSNLMGLCVLGRETLDELTSMVVKLFGEVENKNVP 243
Query: 295 VPLYAEPIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGSG 354
VP + Q EHL++ +V P+KD++ L ++F +PD++++++S P L HLIGHEG G
Sbjct: 244 VPEFPTHPFQEEHLRQFYKVVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPG 303
Query: 355 SLLAHLKKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNS 414
SLL+ LK GW N L G ++G FF +++DLT+ GL H D+I +FQYI+ L+
Sbjct: 304 SLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIIFHMFQYIQKLRTE 363
Query: 415 LPQKWIFNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILAM-GLLTKYEPD 473
PQ+W+F E +D++ F+FK P S +A L Y P+ ILA LL ++ PD
Sbjct: 364 GPQEWVFQECKDLNTVAFRFKDKERPRGYTSKVAGLLH--YYPLEEILAAEYLLEEFRPD 421
Query: 474 LLTQYTDALVPENSRVTLISRSLE--TDSAEKWYGTAYKVVDYPADLIKNMKSPGLNPAL 531
L+ D L PEN RV ++S+S E TD E+WYGT YK + IK + LN
Sbjct: 422 LIEMVLDKLRPENVRVAVVSKSFEGQTDRTEEWYGTQYKQEAITDEAIKKWDNADLNGKF 481
Query: 532 TLPRPNEFVSTNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLP 591
LP NEF+ TNF++ ++ P P L+ +SK+W+K+DD+F+ P+ + F P
Sbjct: 482 KLPMKNEFIPTNFEIYPLEKDSP-SAPTLIKDTAMSKVWFKQDDKFFLPKACLNFEFFSP 540
Query: 592 HTHASIINSMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLIIL 651
+ ++ ++ LY +L D+L + Y A A L T G+ ++ G+N+K IL
Sbjct: 541 FAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTVYGMYLSVKGYNDKQHIL 600
Query: 652 LTRFLQGVNSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKL 711
L + ++ + +FE + RF+I+K+ +R L N E P+ Y ++ E +W+ E
Sbjct: 601 LKKIIEKMATFEIDEKRFDIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELR 660
Query: 712 QVFEKLTFEQLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIHN---LQV 768
+ +T +L FIP + ++ E L+HGNI + ALE+ +++ + + H L
Sbjct: 661 DALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQSALEMMQMLEDTLIEHAHTKPLLPS 720
Query: 769 SNNRLRSYLLPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFAQLIHEPC 828
R R +P G + Y+ ++ + N I+ Q D+ + + L LF Q+I EPC
Sbjct: 721 QLIRYREVQVPDGGWYVYQQ--RNEVHNNCGIEIYYQTDMQNTHENMLLELFCQIISEPC 778
Query: 829 FDTLRTKEQLGYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVLRDMPE 888
F+TLRTKEQLGY+VFS +G +R +IQSE YLE R+ F +T + + +M +
Sbjct: 779 FNTLRTKEQLGYIVFSGPRRANGVQGLRFIIQSEKAPHYLESRVEAFLKTMEKSVEEMGD 838
Query: 889 EDFEKHKEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMIDF 948
E F+KH +AL L K K +A E A+Y I YNF + + +TK+ ++ F
Sbjct: 839 EAFQKHIQALAIRRLDKPKKLAAECAKYWGEIISQQYNFDRDNIEVAYLKTLTKEHIMQF 898
Query: 949 YEN--YIMSENASKLILHLKSQ------VENKELNENELDTAK---YPTGQLIEDVGAFK 997
Y + I + K+ +H+ S+ + + +N+++ A P L++D+ FK
Sbjct: 899 YRDLLAIDAPRRHKVSVHVLSREMDSCPLVGEFPAQNDVNLAPAPSLPQPSLVQDMTEFK 958
Query: 998 STLFVAPVRQPMKDF 1012
+L + P+ +P +F
Sbjct: 959 RSLPLFPLTKPHINF 973
>ref|NP_984913.1| AER053Cp [Ashbya gossypii ATCC 10895]
gb|AAS52737.1| AER053Cp [Ashbya gossypii ATCC 10895]
Length = 1013
Score = 1119 bits (2894), Expect = 0.0, Method: Composition-based stats.
Identities = 576/1001 (57%), Positives = 749/1001 (74%), Gaps = 6/1001 (0%)
Query: 19 TQLVHLSPISLNFTVR-RFKPFTCLSRYYTTNPYNMTSNFKTFNLDFLKPDLDERSYRFI 77
+ +H + T R P +N + S + +P LD+R YR+I
Sbjct: 15 SHFIHRHLQVQSATRRSNLSPLFYSRSM--SNNISGVSGLRELAATLEQPLLDDRKYRYI 72
Query: 78 ELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNLPGLAHFCEHLLFMGSEKFPDENEY 137
ELPN L+ LL+ D DK+AASLDVN+GAFEDP++LPGLAHFCEHLLFMGS+KFP+ENEY
Sbjct: 73 ELPNHLRVLLVHDKNTDKSAASLDVNVGAFEDPEDLPGLAHFCEHLLFMGSKKFPNENEY 132
Query: 138 SSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGALDRFSGFFSCPLFNKDSTDKEINAVN 197
+S+LSKHGG+SNAYTASQNTNY+F VNH++L+ ALDRFSGFFSCPLFN+ ST+KEI AV+
Sbjct: 133 ASFLSKHGGASNAYTASQNTNYYFHVNHENLYDALDRFSGFFSCPLFNESSTEKEIKAVD 192
Query: 198 SENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGTLPKENGLNVRDELLKFHKN 257
SENKKNLQND+WR+YQL KSLTN HPYHKFSTGN ETL ++P+ G+NVRDELLKF+
Sbjct: 193 SENKKNLQNDMWRLYQLGKSLTNPIHPYHKFSTGNFETLWSIPRSKGVNVRDELLKFYNR 252
Query: 258 FYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGREVPLYAEPIMQPEHLQKIIQVRPV 317
YSANLMKL ILGREDLDTL+ W Y+LFKDV N+G +VP Y PEHL K+I+V+PV
Sbjct: 253 SYSANLMKLVILGREDLDTLAQWAYELFKDVPNHGTKVPEYHAQAFTPEHLMKVIKVKPV 312
Query: 318 KDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGSGSLLAHLKKLGWANELSAGGHTVS 377
K+LK +EISF VPDM++HW+ KP R LSHLIGHEG+ SLLA+LK WA +LSAG TVS
Sbjct: 313 KNLKSVEISFVVPDMDKHWQVKPARYLSHLIGHEGTDSLLAYLKNNSWAIDLSAGATTVS 372
Query: 378 KGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLPQKWIFNELQDISNATFKFKQA 437
+GNA+F+V++DLTD G+ Y VI +FQYI MLK LPQ+W+F EL+DI A FKFKQ
Sbjct: 373 EGNAYFSVNVDLTDEGVVQYEAVICAVFQYINMLKEVLPQEWVFTELKDIGEAHFKFKQK 432
Query: 438 GSPSSTVSSLAKCLEKDYIPVSRILAMGLLTKYEPDLLTQYTDALVPENSRVTLISRSLE 497
G+P++TVSSL+K L+K Y+PV IL L+ +YEP L+ +Y ++L ENSRV LIS+ +E
Sbjct: 433 GNPAATVSSLSKNLQKAYLPVQVILNTSLMRQYEPGLIMEYLNSLTLENSRVMLISQKVE 492
Query: 498 TDSAEKWYGTAYKVVDYPADLIKNMKSPGLNPALTLPRPNEFVSTNFKVDKIDG-IKPLD 556
T+ +E+WYGT Y V DY D + ++S G NPAL +P PNEF++T F V K +G +KPL
Sbjct: 493 TNLSERWYGTEYSVADYTKDFVSKIRSLGANPALKIPAPNEFIATRFDVHKDEGNVKPLL 552
Query: 557 EPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLPHTHASIINSMLSTLYTQLANDALKD 616
EP LL D KLWYKKDD FW P+GYIY+S KLPHTH+SI+NSML TLY ND+LKD
Sbjct: 553 EPFLLRDDRCGKLWYKKDDMFWVPKGYIYISMKLPHTHSSIVNSMLCTLYVDHINDSLKD 612
Query: 617 VQYDAACADLRISFNKTNQGLAITASGFNEKLIILLTRFLQGVNSFEPKKDRFEILKDKT 676
+ Y+A CA L IS KTNQGL ++ SG+N+KL++LL RF +G+ +++RF +LK +
Sbjct: 613 LAYNAECAGLEISLRKTNQGLDLSLSGYNDKLLVLLARFFEGIQKLFLREERFMVLKQRL 672
Query: 677 IRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKLQVFEKLTFEQLINFIPTIYEGVYFE 736
I+ L N LY+ PY+Q+ Y+++INERSW+T EKL + E+LTF+ L NF+PTIYE +YFE
Sbjct: 673 IQKLHNHLYDTPYTQIGRLYSSLINERSWTTQEKLDITEQLTFDHLANFVPTIYEQMYFE 732
Query: 737 TLIHGNIKHEEALEVDSLIKSLIPNNIHNLQVSNNRLRSYLLPKGKTFRYETALKDSQNV 796
L+HGN HEEALEV L+ SL+PN I N + N++LRSY +P G + YETAL D +NV
Sbjct: 733 LLVHGNFSHEEALEVYDLVSSLVPNEIRNSEGRNSKLRSYFIPAGGAYHYETALADKENV 792
Query: 797 NSCIQHVTQLDVYSEDLSALSGLFAQLIHEPCFDTLRTKEQLGYVVFSSSLNNHGTANIR 856
NSCIQ V QL YSE LSA L AQ+++EPCF+TLRT+EQLGYVVFSS LN HGT N+R
Sbjct: 793 NSCIQKVIQLGAYSELLSAKGSLLAQMVNEPCFNTLRTEEQLGYVVFSSKLNTHGTVNLR 852
Query: 857 ILIQSEHTTPYLEWRINNFYETFGQVLRDMPEEDFEKHKEALCNSLLQKFKNMAEESARY 916
IL+QSE ++ YLE RI+ + FG L M +FEKHK+A+C +L QK++N+ EE+ RY
Sbjct: 853 ILVQSERSSSYLESRIDTSCQKFGSTLEMMSNAEFEKHKDAICKTLQQKYRNLGEENDRY 912
Query: 917 TAAIYLGDYNFTHRQKKAKLVANITKQQMIDFYENYIMSENASKLILHLKSQVENKELNE 976
IYLGDYNF ++++KA+LV +TK++M+DFY+ I S+ A+ L++H+++Q ++
Sbjct: 913 VTCIYLGDYNFLYKERKAQLVRQLTKKEMLDFYQQTICSKQAASLVVHMQAQAGVQDSPA 972
Query: 977 NELDTAKYPTGQLIEDVGAFKSTLFVAPVRQPMKDFEISAP 1017
+++D YPTG I DVGAFKS L++AP+R P+K FE++ P
Sbjct: 973 DKVD--GYPTGNAITDVGAFKSQLYLAPIRAPIKKFEVTTP 1011
>pdb|2WBY|A Chain A, Crystal Structure Of Human Insulin-Degrading Enzyme In
Complex With Insulin
pdb|2WBY|B Chain B, Crystal Structure Of Human Insulin-Degrading Enzyme In
Complex With Insulin
pdb|2WC0|A Chain A, Crystal Structure Of Human Insulin Degrading Enzyme In
Complex With Iodinated Insulin
pdb|2WC0|B Chain B, Crystal Structure Of Human Insulin Degrading Enzyme In
Complex With Iodinated Insulin
Length = 990
Score = 1118 bits (2891), Expect = 0.0, Method: Composition-based stats.
Identities = 372/976 (38%), Positives = 580/976 (59%), Gaps = 22/976 (2%)
Query: 54 TSNFKTFNLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNL 113
K K D+R YR +EL N +K LLI DP DK++A+LDV+IG+ DP N+
Sbjct: 15 NPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNI 74
Query: 114 PGLAHFCEHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGALD 173
GL+HF +H+LF+G++K+P ENEYS +LS+H GSSNA+T+ ++TNY+F+V+H+HL GALD
Sbjct: 75 AGLSHFLQHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALD 134
Query: 174 RFSGFFSCPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNI 233
RF+ FF PLF++ + D+E+NAV+SE++KN+ ND WR++QL+K+ N KHP+ KF TGN
Sbjct: 135 RFAQFFLSPLFDESAKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNK 194
Query: 234 ETLGTLPKENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGR 293
TL T P + G++VR ELLKFH +YS+NLM + +LGRE LD L++ LF +V N
Sbjct: 195 YTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVVVLGRESLDDLTNLVVKLFSEVENKNV 254
Query: 294 EVPLYAEPIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGS 353
+P + E Q EHL+++ ++ P+KD++ L ++F +PD++++++S P L HLIGHEG
Sbjct: 255 PLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGP 314
Query: 354 GSLLAHLKKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKN 413
GSLL+ LK GW N L G ++G FF +++DLT+ GL H D+I+ +FQYI+ L+
Sbjct: 315 GSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRA 374
Query: 414 SLPQKWIFNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRIL-AMGLLTKYEP 472
PQ+W+F EL+D++ F+FK P S +A L Y P+ +L A LL ++ P
Sbjct: 375 EGPQEWVFQELKDLNAVAFRFKDKERPRGYTSKIAGILH--YYPLEEVLTAEYLLEEFRP 432
Query: 473 DLLTQYTDALVPENSRVTLISRSLE--TDSAEKWYGTAYKVVDYPADLIKNMKSPGLNPA 530
DL+ D L PEN RV ++S+S E TD E+WYGT YK P ++IK ++ LN
Sbjct: 433 DLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGK 492
Query: 531 LTLPRPNEFVSTNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKL 590
LP NEF+ TNF++ ++ + P L+ +SKLW+K+DD+F+ P+ + F
Sbjct: 493 FKLPTKNEFIPTNFEILPLE-KEATPYPALIKDTAMSKLWFKQDDKFFLPKANLNFEFFS 551
Query: 591 PHTHASIINSMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLII 650
P + ++S ++ LY +L D+L + Y A A L T G+ ++ G+N+K I
Sbjct: 552 PFAYVDPLHSNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPI 611
Query: 651 LLTRFLQGVNSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEK 710
LL + ++ + +FE + RFEI+K+ +R L N E P+ Y ++ E +W+ E
Sbjct: 612 LLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDEL 671
Query: 711 LQVFEKLTFEQLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIHN---LQ 767
+ + +T +L FIP + ++ E L+HGNI + AL + +++ + + H L
Sbjct: 672 KEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLP 731
Query: 768 VSNNRLRSYLLPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFAQLIHEP 827
R R LP F Y+ ++ + NS I+ Q D+ S + LFAQ+I EP
Sbjct: 732 SQLVRYREVQLPDRGWFVYQQ--RNEVHNNSGIEIYYQTDMQSTSENMFLELFAQIISEP 789
Query: 828 CFDTLRTKEQLGYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVLRDMP 887
F+TLRTKEQLGY+VFS +G +R +IQSE YLE R+ F T + + DM
Sbjct: 790 AFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMT 849
Query: 888 EEDFEKHKEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMID 947
EE F+KH +AL L K K ++ ESA+Y I YNF + + +TK+ +I
Sbjct: 850 EEAFQKHIQALAIRRLDKPKKLSAESAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIK 909
Query: 948 FYENYIM--SENASKLILHLKSQ------VENKELNENELDTAK---YPTGQLIEDVGAF 996
FY+ + + K+ +H+ ++ V + +N+++ ++ P ++I+++ F
Sbjct: 910 FYKEMLAVDAPRRHKVSVHVLAREMDSNPVVGEFPAQNDINLSQAPALPQPEVIQNMTEF 969
Query: 997 KSTLFVAPVRQPMKDF 1012
K L + P+ +P +F
Sbjct: 970 KRGLPLFPLVKPHINF 985
>ref|XP_447076.1| unnamed protein product [Candida glabrata]
emb|CAG60009.1| unnamed protein product [Candida glabrata CBS 138]
Length = 1008
Score = 1114 bits (2881), Expect = 0.0, Method: Composition-based stats.
Identities = 685/995 (68%), Positives = 824/995 (82%), Gaps = 8/995 (0%)
Query: 27 ISLNFTVRRFKPFTCLSRYYTTNPYNMTSN-----FKTFNLDFLKPDLDERSYRFIELPN 81
L VR F L+ YY Y +N +K + FLKPDLD+R YR+I+LPN
Sbjct: 11 SVLPSGVRIALQFKKLTSYYYKKNYTTVANKSTMPYKDLKVQFLKPDLDDRQYRYIQLPN 70
Query: 82 KLKALLIQDPKADKAAASLDVNIGAFEDPKNLPGLAHFCEHLLFMGSEKFPDENEYSSYL 141
LKAL+IQD DKAAA+LDVNIGAF+DP+NLPGLAHFCEHLLFMGSEKFPDENEYSSYL
Sbjct: 71 NLKALIIQDATTDKAAAALDVNIGAFQDPENLPGLAHFCEHLLFMGSEKFPDENEYSSYL 130
Query: 142 SKHGGSSNAYTASQNTNYFFEVNHQHLFGALDRFSGFFSCPLFNKDSTDKEINAVNSENK 201
SKHGGSSNAYT SQNTNYFFEVN HL GALDRFSGFFSCPLFN++STDKEINAV+SENK
Sbjct: 131 SKHGGSSNAYTGSQNTNYFFEVNADHLHGALDRFSGFFSCPLFNQNSTDKEINAVDSENK 190
Query: 202 KNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGTLPKENGLNVRDELLKFHKNFYSA 261
KNLQNDIWR+YQLDKSL+N HPYHKFSTGN+ETLG PK GL++R+ELLKF+ YSA
Sbjct: 191 KNLQNDIWRMYQLDKSLSNQDHPYHKFSTGNLETLGDKPKAAGLDIREELLKFYNENYSA 250
Query: 262 NLMKLCILGREDLDTLSDWTYDLFKDVANNGREVPLYAEPIMQPEHLQKIIQVRPVKDLK 321
NLMKLCILG+EDLDTLS+W ++LFKDV N+ R +P+Y PI++ L+KII+V+PVKDL+
Sbjct: 251 NLMKLCILGKEDLDTLSEWAWELFKDVKNSDRALPVYDAPILKENDLKKIIKVKPVKDLR 310
Query: 322 KLEISFTVPDMEEHWESKPPRILSHLIGHEGSGSLLAHLKKLGWANELSAGGHTVSKGNA 381
KL+ISF VPD E+ WE+K I SHLIGHEGSGSLLAHLK LGWANEL AGGHTVS GNA
Sbjct: 311 KLDISFVVPDYEKKWEAKISHIFSHLIGHEGSGSLLAHLKSLGWANELGAGGHTVSDGNA 370
Query: 382 FFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLPQKWIFNELQDISNATFKFKQAGSPS 441
FF VDI+LT+ GL HY+D++VLIFQY+EMLK SLPQ+WIF ELQDISNATFKFKQ GS S
Sbjct: 371 FFNVDIELTNEGLKHYKDIVVLIFQYLEMLKTSLPQEWIFKELQDISNATFKFKQKGSAS 430
Query: 442 STVSSLAKCLEKDYI-PVSRILAMGLLTKYEPDLLTQYTDALVPENSRVTLISRSLETDS 500
TVS LAK LEKDY PV ILA LL KYEP+L+ + + PENSR+T ISRS+ DS
Sbjct: 431 QTVSGLAKQLEKDYYFPVENILATNLLVKYEPELIKHFMKSFTPENSRITFISRSIVADS 490
Query: 501 AEKWYGTAYKVVDYPADLIKNMKSPGLNPALTLPRPNEFVSTNFKVDKIDGIKPLDEPVL 560
E+WYGT Y V DY + +K++++PGLNP L++PRPNEF++TNF V+K D +PL+EP+L
Sbjct: 491 KEQWYGTEYSVEDYSPEFLKSIENPGLNPNLSVPRPNEFIATNFDVEKFDVKEPLNEPLL 550
Query: 561 LLSDDVSKLWYKKDDRFWQPRGYIYLSFKLPHTHASIINSMLSTLYTQLANDALKDVQYD 620
L DDVSKLWYKKDDRFWQPRGYIY++ KLP+TH+SII+SML+TLY Q+ NDALKD+QYD
Sbjct: 551 LKDDDVSKLWYKKDDRFWQPRGYIYVTLKLPNTHSSIISSMLTTLYVQMVNDALKDLQYD 610
Query: 621 AACADLRISFNKTNQGLAITASGFNEKLIILLTRFLQGVNSFEPKKDRFEILKDKTIRHL 680
AACA++ +SF KTNQGL IT SGFNEKL+ILL RF++GV FEPKK+RFE+ KDKT+ HL
Sbjct: 611 AACANINLSFVKTNQGLDITISGFNEKLLILLKRFVEGVQGFEPKKERFEVFKDKTVHHL 670
Query: 681 KNLLYEVPYSQMSNYYNAIINERSWSTAEKLQVFEKLTFEQLINFIPTIYEGVYFETLIH 740
KN + EVPYSQ+S YN+++NER+W T EKL+V EKL FEQL NF+ IY+G+Y+E+ +H
Sbjct: 671 KNQMMEVPYSQISGLYNSVVNERTWPTKEKLEVAEKLKFEQLDNFVRAIYDGMYYESFVH 730
Query: 741 GNIKHEEALEVDSLIKSLIPN-NIHNLQVSNNRLRSYLLPKGKTFRYETALKDSQNVNSC 799
GN++ +EA EVDSL+ + + +I N+ V +NRLRSY++PKGK++ YET L D NVNSC
Sbjct: 731 GNLESKEAREVDSLVSTFLKKDDIKNIDVQSNRLRSYIIPKGKSYAYETDLYDENNVNSC 790
Query: 800 IQHVTQLDVYSEDLSALSGLFAQLIHEPCFDTLRTKEQLGYVVFSSSLNNHGTANIRILI 859
IQHV QLDVY+E LSALSGLFAQ++HEPCFD LRTKEQLGYVVFSSSLNNHGTANIRIL+
Sbjct: 791 IQHVVQLDVYNEKLSALSGLFAQMLHEPCFDILRTKEQLGYVVFSSSLNNHGTANIRILV 850
Query: 860 QSEHTTPYLEWRINNFYETFGQVLRDMPEEDFEKHKEALCNSLLQKFKNMAEESARYTAA 919
QSEHTTPYLEWRI+ FY+TFG+ LR+M EEDF KHKEALC +LLQKFKNM EES RY AA
Sbjct: 851 QSEHTTPYLEWRIDEFYKTFGEKLRNMDEEDFNKHKEALCKTLLQKFKNMKEESLRYVAA 910
Query: 920 IYLGDYNFTHRQKKAKLVANITKQQMIDFYENYIMSENASKLILHLKSQVENKELNENEL 979
IYLGDYN+ HRQKKA +V ++TK+ MI F+ENYI S++A+KL++HLKS+ + E +E++L
Sbjct: 911 IYLGDYNYLHRQKKADMVKDLTKEDMIAFFENYIESDDATKLVIHLKSK-KATEKDESQL 969
Query: 980 DTAKYPTGQLIEDVGAFKSTLFVAPVRQPMKDFEI 1014
DT KYP+G+ IEDVG F+S L++AP+RQP K FEI
Sbjct: 970 DTTKYPSGEKIEDVGQFRSQLYLAPLRQPTKKFEI 1004
>sp|P14735|IDE_HUMAN Insulin-degrading enzyme (Insulysin) (Insulinase) (Insulin protease)
gb|AAA52712.1| insulin-degrading enzyme
Length = 1019
Score = 1109 bits (2869), Expect = 0.0, Method: Composition-based stats.
Identities = 371/982 (37%), Positives = 579/982 (58%), Gaps = 22/982 (2%)
Query: 48 TNPYNMTSNFKTFNLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAF 107
T K K D+R YR +EL N +K LL+ DP DK++A+LDV+IG+
Sbjct: 38 TYSKMNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLMSDPTTDKSSAALDVHIGSL 97
Query: 108 EDPKNLPGLAHFCEHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQH 167
DP N+ GL+HFCEH+LF+G++K+P ENEYS +LS+H GSSNA+T+ ++TNY+F+V+H+H
Sbjct: 98 SDPPNIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEH 157
Query: 168 LFGALDRFSGFFSCPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHK 227
L GALDRF+ FF CPLF++ D+E+NAV+SE++KN+ ND WR++QL+K+ N KHP+ K
Sbjct: 158 LEGALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSK 217
Query: 228 FSTGNIETLGTLPKENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKD 287
F TGN TL T P + G++VR ELLKFH +YS+NLM +C+LGRE LD L++ LF +
Sbjct: 218 FGTGNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSE 277
Query: 288 VANNGREVPLYAEPIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHL 347
V N +P + E Q EHL+++ ++ P+KD++ L ++F +PD++++++S P L HL
Sbjct: 278 VENKNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHL 337
Query: 348 IGHEGSGSLLAHLKKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQY 407
IGHEG GSLL+ LK GW N L G ++G FF +++DLT+ GL H D+I+ +FQY
Sbjct: 338 IGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQY 397
Query: 408 IEMLKNSLPQKWIFNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRIL-AMGL 466
I+ L+ PQ+W+F E +D++ F+FK P S +A L Y P+ +L A L
Sbjct: 398 IQKLRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILH--YYPLEEVLTAEYL 455
Query: 467 LTKYEPDLLTQYTDALVPENSRVTLISRSLE--TDSAEKWYGTAYKVVDYPADLIKNMKS 524
L ++ PDL+ D L PEN RV ++S+S E TD E+WYGT YK P ++IK ++
Sbjct: 456 LEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQN 515
Query: 525 PGLNPALTLPRPNEFVSTNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYI 584
LN LP NEF+ TNF++ ++ + P L+ +SKLW+K+DD+ +P+ +
Sbjct: 516 ADLNGKFKLPTKNEFIPTNFEILPLE-KEATPYPALIKDTVMSKLWFKQDDKKKKPKACL 574
Query: 585 YLSFKLPHTHASIINSMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGF 644
F P + ++ ++ LY +L D+L + Y A A L T G+ ++ G+
Sbjct: 575 NFEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGY 634
Query: 645 NEKLIILLTRFLQGVNSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERS 704
N+K ILL + ++ + +FE + RFEI+K+ +R L N E P+ Y ++ E +
Sbjct: 635 NDKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVA 694
Query: 705 WSTAEKLQVFEKLTFEQLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIH 764
W+ E + + +T +L FIP + ++ E L+HGNI + AL + +++ + + H
Sbjct: 695 WTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAH 754
Query: 765 N---LQVSNNRLRSYLLPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFA 821
L R R LP F Y+ ++ + N I+ Q D+ S + LF
Sbjct: 755 TKPLLPSQLVRYREVQLPDRGWFVYQQ--RNEVHNNCGIEIYYQTDMQSTSENMFLELFC 812
Query: 822 QLIHEPCFDTLRTKEQLGYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQ 881
Q+I EPCF+TLRTKEQLGY+VFS +G ++R +IQSE YLE R+ F T +
Sbjct: 813 QIISEPCFNTLRTKEQLGYIVFSGPRRANGIQSLRFIIQSEKPPHYLESRVEAFLITMEK 872
Query: 882 VLRDMPEEDFEKHKEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANIT 941
+ DM EE F+KH +AL L K K ++ E A+Y I YNF + + +T
Sbjct: 873 SIEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLT 932
Query: 942 KQQMIDFYENYIM--SENASKLILHLKSQ------VENKELNENELDTAK---YPTGQLI 990
K+ +I FY+ + + K+ +H+ ++ V + +N+++ ++ P ++I
Sbjct: 933 KEDIIKFYKEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVI 992
Query: 991 EDVGAFKSTLFVAPVRQPMKDF 1012
+++ FK L + P+ +P +F
Sbjct: 993 QNMTEFKRGLPLFPLVKPHINF 1014
>ref|XP_001266332.1| a-pheromone processing metallopeptidase Ste23 [Neosartorya fischeri
NRRL 181]
gb|EAW24435.1| a-pheromone processing metallopeptidase Ste23 [Neosartorya fischeri
NRRL 181]
Length = 1155
Score = 1099 bits (2843), Expect = 0.0, Method: Composition-based stats.
Identities = 386/997 (38%), Positives = 583/997 (58%), Gaps = 18/997 (1%)
Query: 2 GVSLLASSSAFVTKPLLTQLVHLSPISLNFTVRRFKPFTCLSRYYTTNPYNMTSNFKTFN 61
++ A + F + P S +S ++ R T ++ M S +
Sbjct: 33 SIASTAIAPHFSSSPRRRLNCPQSLLSRCWSRRSLSRSTV--APFSAAAVTMGS-IQHIT 89
Query: 62 LDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNLPGLAHFCE 121
KP+LD+RSYR I L NKL+ALL+ DP+ DKA+AS++VN+G F D ++PG+AH E
Sbjct: 90 EHLEKPELDDRSYRVIRLSNKLEALLVHDPETDKASASVNVNVGNFSDADDMPGMAHAVE 149
Query: 122 HLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGALDRFSGFFSC 181
HLLFMG++KFP EN Y+ YL+ H GSSNAYTA+ TNYFFE L+GALDRF+ FF
Sbjct: 150 HLLFMGTKKFPKENAYNQYLASHSGSSNAYTAATETNYFFE-PSSPLYGALDRFAQFFVS 208
Query: 182 PLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGTLPK 241
PLF + + D+E+ AV+SENKKNLQ+D+WR+ QL+KSL+N HPYH FSTGN++TL P+
Sbjct: 209 PLFLESTLDRELRAVDSENKKNLQSDLWRLMQLNKSLSNPAHPYHHFSTGNLKTLKEDPQ 268
Query: 242 ENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGREVPLYAE- 300
+ GL VR E +KF++ YSAN M+LC+LGRE LD L W +LF +V N + +
Sbjct: 269 QRGLEVRSEFIKFYQKHYSANRMRLCVLGRESLDELEKWVEELFSEVENKDLPQNRWDDV 328
Query: 301 PIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGSGSLLAHL 360
+ E L I +PV D + L+I F D E +ES+P R +SHLIGHEG GS+LA++
Sbjct: 329 QPWRDEDLGIQIFAKPVMDTRSLDIYFPFLDEETLYESQPSRYISHLIGHEGPGSILAYI 388
Query: 361 KKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLPQKWI 420
K GWAN LSAG + G A F + I LT GL YR+V ++FQYI MLK PQ+W+
Sbjct: 389 KAKGWANGLSAGVMPICPGAAAFTISIRLTKEGLQQYREVAKVVFQYIAMLKEREPQQWV 448
Query: 421 FNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILAMGLLTKYEPDLLTQYTD 480
F+E+++++ F+FKQ S S L+ ++K P +L+ LL K++PDL+ +
Sbjct: 449 FDEMKNLAEVEFRFKQKSPASRFTSRLSSVMQKPL-PREWLLSGSLLRKFDPDLIKKALS 507
Query: 481 ALVPENSRVTLISRSLE--TDSAEKWYGTAYKVVDYPADLIKNMKSP------GLNPALT 532
L P+N R+ ++S+ +S EKWYGT YKV P D + +++ L
Sbjct: 508 YLRPDNFRLIVVSQEYPGDWNSKEKWYGTEYKVGKIPQDFMADIREALDSTPETRLSELH 567
Query: 533 LPRPNEFVSTNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLPH 592
+P NEFV T V+K + +P P L+ DD +LW+KKDDRFW P+G ++++ + P
Sbjct: 568 MPHKNEFVPTRLSVEKKEVAEPAKTPKLIRHDDHVRLWFKKDDRFWVPKGTVHITLRNPL 627
Query: 593 THASIINSMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLIILL 652
A+ N + S LY +L DAL + YDA A L + + GL ++ G+N+K+ +LL
Sbjct: 628 AWATPANLVKSKLYCELVKDALVEYSYDAELAGLDYHLSASVFGLDVSVGGYNDKMAVLL 687
Query: 653 TRFLQGVNSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKLQ 712
+ + +RF I+K++ R +N Y+ P+ Q+ +Y + +E++W +
Sbjct: 688 EKVFTSMRDLVVNPNRFHIIKERLSRGYRNAEYQQPFYQVGDYTRYLTSEKTWINEQYAA 747
Query: 713 VFEKLTFEQLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIHNLQVSNNR 772
E + E + NF P + + E L HGN+ E+AL++ L+++++ + + R
Sbjct: 748 ELEHIDAEDISNFFPQLLSQNHIEVLAHGNLYKEDALKMTDLVENILQSRPLPQSQWHVR 807
Query: 773 LRSYLLPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSED-LSALSGLFAQLIHEPCFDT 831
R+ ++P G + YE L+D N+N CI++ + ++D L A LFAQ+ EP FD
Sbjct: 808 -RNIIIPPGSNYVYERTLRDPANINHCIEYYVYVGSITDDMLRAKLLLFAQMTDEPAFDQ 866
Query: 832 LRTKEQLGYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVLRDMPEEDF 891
LR+KEQLGYVV+S + + T R++IQSE T YLE RI+NF G+ L +M E+DF
Sbjct: 867 LRSKEQLGYVVWSGARYSATTIGYRVIIQSERTAEYLESRIDNFLIQTGETLENMSEKDF 926
Query: 892 EKHKEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMIDFYEN 951
E HK ++ N L+K KN++ E++R+ + I ++F + A V +TK ++DFY+
Sbjct: 927 EGHKRSVINKRLEKLKNLSSETSRFWSHIGSEYFDFLQNESDAANVRALTKADIVDFYKQ 986
Query: 952 YI--MSENASKLILHLKSQVENKELNENELDTAKYPT 986
+ S KL ++L +Q E + ++ +
Sbjct: 987 LLDPRSPTRGKLSIYLNAQGGAHAKVEGKDQQSRLVS 1023
>ref|XP_454175.1| unnamed protein product [Kluyveromyces lactis]
emb|CAG99262.1| unnamed protein product [Kluyveromyces lactis NRRL Y-1140]
Length = 1004
Score = 1097 bits (2838), Expect = 0.0, Method: Composition-based stats.
Identities = 582/979 (59%), Positives = 760/979 (77%), Gaps = 8/979 (0%)
Query: 40 TCL--SRYYTT-NPYNMTSNFKTFNLD--FLKPDLDERSYRFIELPNKLKALLIQDPKAD 94
+CL SRY M++ ++T D FLKPDLD+R YR+I+LPN LKALLI D +AD
Sbjct: 23 SCLLTSRYRFLHYNTKMSNKYRTLGTDSEFLKPDLDDRKYRYIQLPNNLKALLISDAEAD 82
Query: 95 KAAASLDVNIGAFEDPKNLPGLAHFCEHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTAS 154
KAAA+LDVNIG+F+DP++LPGLAHFCEHLLFMG+EK+PDEN+YSS+LSKHGGSSNAYT S
Sbjct: 83 KAAAALDVNIGSFQDPEHLPGLAHFCEHLLFMGNEKYPDENDYSSFLSKHGGSSNAYTGS 142
Query: 155 QNTNYFFEVNHQHLFGALDRFSGFFSCPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQL 214
QNTNY+F +NH++L+ ALDRFSGFFSCPLFNK STDKEINAV+SENKKNLQNDIWR+YQL
Sbjct: 143 QNTNYYFHLNHENLYPALDRFSGFFSCPLFNKASTDKEINAVDSENKKNLQNDIWRMYQL 202
Query: 215 DKSLTNTKHPYHKFSTGNIETLGTLPKENGLNVRDELLKFHKNFYSANLMKLCILGREDL 274
DKSLTN +HPYHKFSTGNI+TLG +PK G+++R+ELL FHKN YSANLMKLC+LGREDL
Sbjct: 203 DKSLTNWEHPYHKFSTGNIKTLGDIPKLKGIDIRNELLDFHKNNYSANLMKLCVLGREDL 262
Query: 275 DTLSDWTYDLFKDVANNGREVPLYAEPIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEE 334
DTL+DW Y+LFKDV N ++VP Y + L+K++ +PVKDLKK+E +F PDM+
Sbjct: 263 DTLADWVYELFKDVPNLNKQVPYYPARLYTESQLKKMVYCKPVKDLKKIEFTFPTPDMDP 322
Query: 335 HWESKPPRILSHLIGHEGSGSLLAHLKKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGL 394
+WESKP LSHLIGHEG+GSLLA LK+ GWA ELSAG HT+SK NA F ++IDLTD+G+
Sbjct: 323 YWESKPNHYLSHLIGHEGNGSLLAFLKEKGWAVELSAGSHTISKDNAVFGIEIDLTDDGM 382
Query: 395 THYRDVIVLIFQYIEMLKNSLPQKWIFNELQDISNATFKFKQAGSPSSTVSSLAKCLEKD 454
H ++I+ FQY+EMLK +LP++WI NEL+ S ++FKFKQ PSSTVS++A+CLEK+
Sbjct: 383 NHVNEIIISTFQYLEMLKVTLPEEWIHNELKSTSVSSFKFKQKDPPSSTVSNMARCLEKE 442
Query: 455 YIPVSRILAMGLLTKYEPDLLTQYTDALVPENSRVTLISRSLETDSAEKWYGTAYKVVDY 514
YIPV IL+ L+ +Y P ++ +Y +L ENSR+ L ++L D E+WYGT YKV DY
Sbjct: 443 YIPVVDILSTSLIREYNPSMIKKYVQSLNWENSRIMLTGQNLPVDCKEQWYGTEYKVTDY 502
Query: 515 PADLIKNMKSPGLNPALTLPRPNEFVSTNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKD 574
P L+K + + GLNP LPRPNEF+ T F+V+K+D +KPLDEP LL D SKLWYKKD
Sbjct: 503 PESLLKKLPNVGLNPKFHLPRPNEFICTKFEVNKLDNVKPLDEPFLLKDDHYSKLWYKKD 562
Query: 575 DRFWQPRGYIYLSFKLPHTHASIINSMLSTLYTQLANDALKDVQYDAACADLRISFNKTN 634
DRFW P+G+IY+S KLPHT +S++NSML++LY + DAL D+QYDA+CADLRI+ KTN
Sbjct: 563 DRFWVPKGHIYVSMKLPHTFSSVVNSMLTSLYVDMIKDALVDLQYDASCADLRITLGKTN 622
Query: 635 QGLAITASGFNEKLIILLTRFLQGVNSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSN 694
QG+ I ASG+NEKL ILLTRFL+G+ SF+PK+ RF ++K++ ++ L N Y+VPY+Q+SN
Sbjct: 623 QGIDIQASGYNEKLTILLTRFLEGIKSFQPKESRFNVIKNRLLQKLSNQQYDVPYNQISN 682
Query: 695 YYNAIINERSWSTAEKLQVFEKLTFEQLINFIPTIYEGVYFETLIHGNIKHEEALEVDSL 754
+N+++NERSW+T KL V + LTFE L +F+PTIYE ++ E+L+ GN E A E++ L
Sbjct: 683 VFNSLVNERSWTTKAKLDVTKDLTFEHLKSFVPTIYEQLFHESLVLGNFSVEMAYEINQL 742
Query: 755 IKSLIPNNIHNLQVSNNRLRSYLLPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLS 814
+ L+ + I NL+V NN+LRSY+LP+ FRYE L+D NVNSCIQ++ QL YSE+L+
Sbjct: 743 VDILVVDRIPNLEVKNNKLRSYILPEESAFRYEYMLEDKANVNSCIQYLIQLGAYSEELA 802
Query: 815 ALSGLFAQLIHEPCFDTLRTKEQLGYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINN 874
A + L +QLIHEPCFDTLRTKEQLGY+VFS+ N HGT N+R+L+QSE + Y+E RI
Sbjct: 803 AKASLVSQLIHEPCFDTLRTKEQLGYIVFSAVANTHGTTNLRVLVQSERDSAYVESRIVK 862
Query: 875 FYETFGQVLRDMPEEDFEKHKEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKA 934
F +FG+ L++MPEE FEKHK L +LLQK N+ +E R+T AIYL DYNF Q++A
Sbjct: 863 FLNSFGEALKEMPEEAFEKHKSGLIKNLLQKLTNLRQEYDRFTTAIYLADYNFCSYQRRA 922
Query: 935 KLVANITKQQMIDFYENYIMSENASKLILHLKSQVENKELNENELDTAKYPTGQLIEDVG 994
++ ++K+ M++FY+N+++S +S+L +HLKSQ+E K E +PTG LI D+
Sbjct: 923 DIITKLSKEDMVEFYKNFVLSPRSSRLAIHLKSQIEKKSTEEV---VEGFPTGTLISDID 979
Query: 995 AFKSTLFVAPVRQPMKDFE 1013
FKS LF+APVRQ +K +E
Sbjct: 980 EFKSNLFLAPVRQAVKQYE 998
>ref|XP_001847597.1| metalloprotease [Culex pipiens quinquefasciatus]
gb|EDS26498.1| metalloprotease [Culex pipiens quinquefasciatus]
Length = 998
Score = 1096 bits (2835), Expect = 0.0, Method: Composition-based stats.
Identities = 357/993 (35%), Positives = 572/993 (57%), Gaps = 21/993 (2%)
Query: 38 PFTCLSRYYTTNPYNMTSNFKTFNLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAA 97
L + TT P + ++ T D +K D R YR + L N LK LLI DP DK+A
Sbjct: 2 NAASLPKIATTAPVTVGADKLTRFDDIVKSQQDNRLYRGLRLSNGLKVLLISDPTTDKSA 61
Query: 98 ASLDVNIGAFEDPKNLPGLAHFCEHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNT 157
A+L V +G DP +PGLAHFCEH+LF+G++K+ +EN+Y ++LS++GGSSNA T + T
Sbjct: 62 AALAVEVGHLSDPDEIPGLAHFCEHMLFLGTKKYINENDYMAFLSENGGSSNAATYADTT 121
Query: 158 NYFFEVNHQHLFGALDRFSGFFSCPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKS 217
Y+F+V + L ALDRFS FF PLF + +T++EINAV+SE++KNL D+WRI Q++KS
Sbjct: 122 KYYFDVVPEKLQEALDRFSQFFIAPLFTESATEREINAVHSEHEKNLSMDVWRIRQVNKS 181
Query: 218 LTNTKHPYHKFSTGNIETLGTLPKENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTL 277
L + KHPY+KF TG+ +TL PK + +N+R+EL+KFH +YSAN+M L + G+E LD L
Sbjct: 182 LCDPKHPYNKFGTGSKKTLLEDPKLSKINIREELMKFHSKWYSANIMSLAVFGKESLDEL 241
Query: 278 SDWTYDLFKDVANNGREVPLYAEPIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWE 337
+F D+ N P + + + EHL V PVKD + L I+F D+E +++
Sbjct: 242 ESMVVSMFSDIENKNVTSPCWKDLPFKEEHLATKTTVVPVKDTRSLTITFQTEDLERYYK 301
Query: 338 SKPPRILSHLIGHEGSGSLLAHLKKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHY 397
+ P +SHLIGHEG+GS+L+ LK GW N L G T+ +G FF V +DLT +G H
Sbjct: 302 AGPEHYVSHLIGHEGAGSILSELKAKGWCNNLVGGYSTIGRGFGFFEVMVDLTQDGFDHV 361
Query: 398 RDVIVLIFQYIEMLKNSLPQKWIFNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIP 457
D++ +IFQYI MLK PQKWIF E D+ F+FK +P S VS++ ++ Y
Sbjct: 362 DDIVKIIFQYIHMLKTEGPQKWIFEEYCDLCEMQFRFKDKENPLSLVSNVVHSMQ-SYPL 420
Query: 458 VSRILAMGLLTKYEPDLLTQYTDALVPENSRVTLISRSLE--TDSAEKWYGTAYKVVDYP 515
+ A L++++ P+L+ + + P+N+R+T++ + E T+ E+WYGT Y P
Sbjct: 421 EEVLAAPYLISEWRPELIEELWNKFFPQNARITVVGQKCESVTNQEEEWYGTKYSSEAIP 480
Query: 516 ADLIKNMKSPGLNPALTLPRPNEFVSTNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDD 575
++++ P LN L LP N F+ T+F++ +D PV++ + + ++W+K+D
Sbjct: 481 KNVLEEWAKPDLNANLHLPERNPFIPTDFELVPVDA-DIQSTPVIIHNTPMIRVWFKQDV 539
Query: 576 RFWQPRGYIYLSFKLPHTHASIINSMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQ 635
F +P+ + L F P ++ +N L+ L+ QL D L + Y A A LR+ + T
Sbjct: 540 EFLKPKTLMNLDFCSPIVYSDPLNCNLTHLFVQLFKDHLNEYLYAADLAGLRLVVSNTTY 599
Query: 636 GLAITASGFNEKLIILLTRFLQGVNSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNY 695
G++++ G++ K ILL + L + +F+ + RF+ILK++ +R+LKN E PY Y
Sbjct: 600 GISVSIGGYSHKQHILLEKVLDNLYNFKIDEKRFDILKEQYVRNLKNYNAEQPYQHAVYY 659
Query: 696 YNAIINERSWSTAEKLQVFEKLTFEQLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLI 755
++ E++WS E + + L+ ++L +FI + ++ E I+GN+ E ALE+ +
Sbjct: 660 LALLLTEQAWSKQELIDAADLLSVDRLRSFIDELLSRMHVECFIYGNVNKENALEISGKV 719
Query: 756 KSLIPNNIHNLQVSNNRL----RSYLLPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSE 811
+ + N ++ R R Y L G+ +ET + + +SC + Q + +
Sbjct: 720 EDKLKNTDASVVPLLARQLMLKREYKLNNGENCLFET--NNDYHKSSCAELYLQCGMQDD 777
Query: 812 DLSALSGLFAQLIHEPCFDTLRTKEQLGYVVFSSSLNNHGTANIRILIQSEHTTPYLEWR 871
+ L Q++ EPC++ LRTKEQLGY+VF S ++G IR+++QS Y+E R
Sbjct: 778 QSNVFVDLVTQILSEPCYNQLRTKEQLGYIVFCGSRKSNGVQGIRVIVQSAKHPAYVEER 837
Query: 872 INNFYETFGQVLRDMPEEDFEKHKEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQ 931
I +F + L +M EE+F++HKEAL L+K K ++ + ++ I L Y+F Q
Sbjct: 838 IEHFLNGMIEQLENMSEEEFKRHKEALAAQKLEKPKRLSTQFGKFLTEISLQQYHFNRAQ 897
Query: 932 KKAKLVANITKQQMIDFYENYIM--SENASKLILHLKSQVEN---------KELNENELD 980
+ + +TKQQ+I++Y++YI+ + + L +H+ S E + + +
Sbjct: 898 VEVAFLQTLTKQQIIEYYKDYIILGAPSRRSLSIHVVSTAEGGAGHRDAPPEATERSTNE 957
Query: 981 TAKYPTGQLIEDVGAFKSTLFVAPVRQPMKDFE 1013
TA + D+ +FKST + P+ QP D +
Sbjct: 958 TADAKDFVKVCDLASFKSTRALYPMVQPYIDIK 990
>ref|XP_748141.1| a-pheromone processing metallopeptidase Ste23 [Aspergillus fumigatus
Af293]
gb|EAL86103.1| a-pheromone processing metallopeptidase Ste23 [Aspergillus fumigatus
Af293]
Length = 1154
Score = 1094 bits (2829), Expect = 0.0, Method: Composition-based stats.
Identities = 384/959 (40%), Positives = 571/959 (59%), Gaps = 16/959 (1%)
Query: 40 TCLSRYYTTNPYNMTSNFKTFNLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAAS 99
++T M S + KP+LD+RSYR I L NKL+ALL+ DP+ DKA+AS
Sbjct: 68 RSTVAPFSTAAVTMGS-IQRITEHLEKPELDDRSYRVIRLSNKLEALLVHDPETDKASAS 126
Query: 100 LDVNIGAFEDPKNLPGLAHFCEHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNY 159
++VN+G F D ++PG+AH EHLLFMG++KFP EN Y+ YL+ H GSSNAYTA+ TNY
Sbjct: 127 VNVNVGNFSDADDMPGMAHAVEHLLFMGTKKFPKENAYNQYLASHSGSSNAYTAATETNY 186
Query: 160 FFEVNHQHLFGALDRFSGFFSCPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLT 219
FFE L+GALDRF+ FF PLF + + D+E+ AV+SENKKNLQ+D+WR+ QL+KSL+
Sbjct: 187 FFE-PSSPLYGALDRFAQFFVSPLFLESTLDRELRAVDSENKKNLQSDLWRLMQLNKSLS 245
Query: 220 NTKHPYHKFSTGNIETLGTLPKENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSD 279
N HPYH FSTGN++TL P++ GL VR E +KF++ YSAN MKLC+LGRE LD L
Sbjct: 246 NPAHPYHHFSTGNLKTLKEDPQQRGLEVRSEFIKFYQKHYSANRMKLCVLGRESLDELEK 305
Query: 280 WTYDLFKDVANNGREVPLYAE-PIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWES 338
W +LF +V N + + + E L I +PV D + L+I F D E +ES
Sbjct: 306 WVEELFSEVENKDLPQNRWDDVQPWRHEDLGIQIFAKPVMDTRSLDIYFPFLDEETLYES 365
Query: 339 KPPRILSHLIGHEGSGSLLAHLKKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYR 398
+P R +SHLIGHEG GS+LA++K GWAN LSAG + G A F + I LT GL YR
Sbjct: 366 QPSRYISHLIGHEGPGSILAYIKAKGWANGLSAGVMPICPGAAAFTISIRLTKEGLQQYR 425
Query: 399 DVIVLIFQYIEMLKNSLPQKWIFNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPV 458
+V ++FQYI MLK PQ+W+F+E+++++ F+FKQ S S L+ ++K P
Sbjct: 426 EVAKVVFQYIAMLKEREPQQWVFDEMKNMAEVEFRFKQKSPASRFTSRLSSVMQKPL-PR 484
Query: 459 SRILAMGLLTKYEPDLLTQYTDALVPENSRVTLISRSLE--TDSAEKWYGTAYKVVDYPA 516
+L+ LL K++PDL+ + L P+N R+ ++S+ DS EKWYGT YKV P
Sbjct: 485 EWLLSGSLLRKFDPDLIKKALSYLRPDNFRLIVVSQEYPGDWDSKEKWYGTEYKVGKIPE 544
Query: 517 DLIKNMKSP-GLNPA-----LTLPRPNEFVSTNFKVDKIDGIKPLDEPVLLLSDDVSKLW 570
D + +++ P L +P NEFV T V+K + +P P L+ DD +LW
Sbjct: 545 DFMADIREALDTTPETRLSDLHMPHKNEFVPTRLSVEKKEVSEPAKTPKLIRHDDHVRLW 604
Query: 571 YKKDDRFWQPRGYIYLSFKLPHTHASIINSMLSTLYTQLANDALKDVQYDAACADLRISF 630
+KKDDRFW P+G ++++ + P A+ N + S LY +L DAL + YDA A L
Sbjct: 605 FKKDDRFWVPKGTVHITLRNPLAWATPANLVKSKLYCELVKDALVEYSYDAELAGLDYHL 664
Query: 631 NKTNQGLAITASGFNEKLIILLTRFLQGVNSFEPKKDRFEILKDKTIRHLKNLLYEVPYS 690
+ + GL ++ G+N+K+ +LL + + +RF I+K++ R +N Y+ P+
Sbjct: 665 SASVFGLDVSVGGYNDKMAVLLEKVFTSMRDLVVNPNRFHIIKERLSRGYRNAEYQQPFY 724
Query: 691 QMSNYYNAIINERSWSTAEKLQVFEKLTFEQLINFIPTIYEGVYFETLIHGNIKHEEALE 750
Q+ +Y + +E++W + E + E + +F P + + E L HGN+ E+AL+
Sbjct: 725 QVGDYTRYLTSEKTWINEQYAAELEHIEAEDISSFFPQLLSQNHIEVLAHGNLYKEDALK 784
Query: 751 VDSLIKSLIPNNIHNLQVSNNRLRSYLLPKGKTFRYETALKDSQNVNSCIQHVTQLDVYS 810
+ L+++++ + + R R+ ++P G F YE L+D N+N CI++ + +
Sbjct: 785 MTDLVENILQSRPLPQSQWHVR-RNIIIPPGSNFIYERTLRDPANINHCIEYYVYVGSIT 843
Query: 811 ED-LSALSGLFAQLIHEPCFDTLRTKEQLGYVVFSSSLNNHGTANIRILIQSEHTTPYLE 869
+D L A LFAQ+ EP FD LR+KEQLGYVV+S + + T R++IQSE T YLE
Sbjct: 844 DDMLRAKLLLFAQMTDEPAFDQLRSKEQLGYVVWSGARYSATTIGYRVIIQSERTAEYLE 903
Query: 870 WRINNFYETFGQVLRDMPEEDFEKHKEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTH 929
RI+NF G+ L +M E+DFE HK ++ N L+K KN++ E++R+ + I ++F
Sbjct: 904 SRIDNFLIQTGETLENMSEKDFEGHKRSVINKRLEKLKNLSSETSRFWSHIGSEYFDFLQ 963
Query: 930 RQKKAKLVANITKQQMIDFYENYI--MSENASKLILHLKSQVENKELNENELDTAKYPT 986
+ A V +TK ++DFY+ I S KL ++L +Q E + ++ +
Sbjct: 964 NESDAANVRALTKADIVDFYKQLIDPRSPTRGKLSIYLNAQGGAHAKLEGKDQQSRLVS 1022
>gb|EDP51051.1| a-pheromone processing metallopeptidase Ste23 [Aspergillus fumigatus
A1163]
Length = 1154
Score = 1092 bits (2825), Expect = 0.0, Method: Composition-based stats.
Identities = 383/959 (39%), Positives = 571/959 (59%), Gaps = 16/959 (1%)
Query: 40 TCLSRYYTTNPYNMTSNFKTFNLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAAS 99
++T M S + KP+LD+RSYR I L NKL+ALL+ DP+ DKA+AS
Sbjct: 68 RSTVAPFSTAAVTMGS-IQRITEHLEKPELDDRSYRVIRLSNKLEALLVHDPETDKASAS 126
Query: 100 LDVNIGAFEDPKNLPGLAHFCEHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNY 159
++VN+G F D ++PG+AH EHLLFMG++KFP EN Y+ YL+ H GSSNAYTA+ TNY
Sbjct: 127 VNVNVGNFSDADDMPGMAHAVEHLLFMGTKKFPKENAYNQYLASHSGSSNAYTAATETNY 186
Query: 160 FFEVNHQHLFGALDRFSGFFSCPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLT 219
FFE L+GALDRF+ FF PLF + + D+E+ AV+SENKKNLQ+D+WR+ QL+KSL+
Sbjct: 187 FFE-PSSPLYGALDRFAQFFVSPLFLESTLDRELRAVDSENKKNLQSDLWRLMQLNKSLS 245
Query: 220 NTKHPYHKFSTGNIETLGTLPKENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSD 279
N HPYH FSTGN++TL P++ GL VR E +KF++ YSAN MKLC+LGRE LD L
Sbjct: 246 NPAHPYHHFSTGNLKTLKEDPQQRGLEVRSEFIKFYQKHYSANRMKLCVLGRESLDELEK 305
Query: 280 WTYDLFKDVANNGREVPLYAE-PIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWES 338
W +LF +V N + + + E L I +PV D + ++I F D E +ES
Sbjct: 306 WVEELFSEVENKDLPQNRWDDVQPWRHEDLGIQIFAKPVMDTRSVDIYFPFLDEETLYES 365
Query: 339 KPPRILSHLIGHEGSGSLLAHLKKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYR 398
+P R +SHLIGHEG GS+LA++K GWAN LSAG + G A F + I LT GL YR
Sbjct: 366 QPSRYISHLIGHEGPGSILAYIKAKGWANGLSAGVMPICPGAAAFTISIRLTKEGLQQYR 425
Query: 399 DVIVLIFQYIEMLKNSLPQKWIFNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPV 458
+V ++FQYI MLK PQ+W+F+E+++++ F+FKQ S S L+ ++K P
Sbjct: 426 EVAKVVFQYIAMLKEREPQQWVFDEMKNLAEVEFRFKQKSPASRFTSRLSSVMQKPL-PR 484
Query: 459 SRILAMGLLTKYEPDLLTQYTDALVPENSRVTLISRSLE--TDSAEKWYGTAYKVVDYPA 516
+L+ LL K++PDL+ + L P+N R+ ++S+ DS EKWYGT YKV P
Sbjct: 485 EWLLSGSLLRKFDPDLIKKALSYLRPDNFRLIVVSQEYPGDWDSKEKWYGTEYKVGKIPE 544
Query: 517 DLIKNMKSP-GLNPA-----LTLPRPNEFVSTNFKVDKIDGIKPLDEPVLLLSDDVSKLW 570
D + +++ P L +P NEFV T V+K + +P P L+ DD +LW
Sbjct: 545 DFMADIREALDTTPETRLSDLHMPHKNEFVPTRLSVEKKEVSEPAKTPKLIRHDDHVRLW 604
Query: 571 YKKDDRFWQPRGYIYLSFKLPHTHASIINSMLSTLYTQLANDALKDVQYDAACADLRISF 630
+KKDDRFW P+G ++++ + P A+ N + S LY +L DAL + YDA A L
Sbjct: 605 FKKDDRFWVPKGTVHITLRNPLAWATPANLVKSKLYCELVKDALVEYSYDAELAGLDYHL 664
Query: 631 NKTNQGLAITASGFNEKLIILLTRFLQGVNSFEPKKDRFEILKDKTIRHLKNLLYEVPYS 690
+ + GL ++ G+N+K+ +LL + + +RF I+K++ R +N Y+ P+
Sbjct: 665 SASVFGLDVSVGGYNDKMAVLLEKVFTSMRDLVVNPNRFHIIKERLSRGYRNAEYQQPFY 724
Query: 691 QMSNYYNAIINERSWSTAEKLQVFEKLTFEQLINFIPTIYEGVYFETLIHGNIKHEEALE 750
Q+ +Y + +E++W + E + E + +F P + + E L HGN+ E+AL+
Sbjct: 725 QVGDYTRYLTSEKTWINEQYAAELEHIEAEDISSFFPQLLSQNHIEVLAHGNLYKEDALK 784
Query: 751 VDSLIKSLIPNNIHNLQVSNNRLRSYLLPKGKTFRYETALKDSQNVNSCIQHVTQLDVYS 810
+ L+++++ + + R R+ ++P G F YE L+D N+N CI++ + +
Sbjct: 785 MTDLVENILQSRPLPQSQWHVR-RNIIIPPGSNFIYERTLRDPANINHCIEYYVYVGSIT 843
Query: 811 ED-LSALSGLFAQLIHEPCFDTLRTKEQLGYVVFSSSLNNHGTANIRILIQSEHTTPYLE 869
+D L A LFAQ+ EP FD LR+KEQLGYVV+S + + T R++IQSE T YLE
Sbjct: 844 DDMLRAKLLLFAQMTDEPAFDQLRSKEQLGYVVWSGARYSATTIGYRVIIQSERTAEYLE 903
Query: 870 WRINNFYETFGQVLRDMPEEDFEKHKEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTH 929
RI+NF G+ L +M E+DFE HK ++ N L+K KN++ E++R+ + I ++F
Sbjct: 904 SRIDNFLIQTGETLENMSEKDFEGHKRSVINKRLEKLKNLSSETSRFWSHIGSEYFDFLQ 963
Query: 930 RQKKAKLVANITKQQMIDFYENYI--MSENASKLILHLKSQVENKELNENELDTAKYPT 986
+ A V +TK ++DFY+ I S KL ++L +Q E + ++ +
Sbjct: 964 NESDAANVRALTKADIVDFYKQLIDPRSPTRGKLSIYLNAQGGAHTKLEGKDQQSRLVS 1022
>ref|XP_534963.2| PREDICTED: similar to Insulin-degrading enzyme (Insulysin)
(Insulinase) (Insulin protease) [Canis familiaris]
Length = 994
Score = 1086 bits (2809), Expect = 0.0, Method: Composition-based stats.
Identities = 364/982 (37%), Positives = 566/982 (57%), Gaps = 47/982 (4%)
Query: 48 TNPYNMTSNFKTFNLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAF 107
+ K +K D+R YR +EL N +K LLI DP DK++A+LDV+IG+
Sbjct: 38 SYSKMNNPAIKRLGNHIIKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSL 97
Query: 108 EDPKNLPGLAHFCEHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQH 167
DP N+ GL+HFCEH+LF+G++K+P ENEYS +LS+H GSSNA+T+ ++TNY+F+V+H+H
Sbjct: 98 SDPPNIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEH 157
Query: 168 LFGALDRFSGFFSCPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHK 227
L GALDRF+ FF CPLF++ D+E+NAV+SE++KN+ ND WR++QL+K+ N KHP+ K
Sbjct: 158 LEGALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSK 217
Query: 228 FSTGNIETLGTLPKENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKD 287
F TGN TL T P + G++VR ELLKFH +YS+NLM +C+LGRE LD L++ LF +
Sbjct: 218 FGTGNKYTLETRPNQEGIDVRQELLKFHSTYYSSNLMAICVLGRESLDDLTNLVVKLFSE 277
Query: 288 VANNGREVPLYAEPIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHL 347
V N +P + E Q EHL+++ ++ P+KD++ L ++F +PD++++++S P L HL
Sbjct: 278 VENKNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHL 337
Query: 348 IGHEGSGSLLAHLKKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQY 407
IGHEG GSLL+ LK GW N L G ++G FF +++DLT+ GL H D+I+ +FQY
Sbjct: 338 IGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQY 397
Query: 408 IEMLKNSLPQKWIFNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRIL-AMGL 466
I+ L+ PQ+W+F E +D++ F+FK P S +A L Y P+ +L A L
Sbjct: 398 IQKLRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILH--YYPLEEVLTAEYL 455
Query: 467 LTKYEPDLLTQYTDALVPENSRVTLISRSLE--TDSAEKWYGTAYKVVDYPADLIKNMKS 524
L ++ PDL+ D L PEN RV ++S+S E TD E+WYGT YK P ++IK
Sbjct: 456 LEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAVPDEVIK---- 511
Query: 525 PGLNPALTLPRPNEFVSTNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYI 584
L+L + P L+ +SKLW+K+DD+F+ P+ +
Sbjct: 512 -----ILSL-----------------EKEAHPYPSLIKDTAMSKLWFKQDDKFFLPKACL 549
Query: 585 YLSFKLPHTHASIINSMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGF 644
F P + ++ ++ LY +L D+L + Y A A L T G+ ++ G+
Sbjct: 550 NFEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGY 609
Query: 645 NEKLIILLTRFLQGVNSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERS 704
N+K ILL + ++ + +FE + RFEI+K+ +R L N E P+ Y ++ E +
Sbjct: 610 NDKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVA 669
Query: 705 WSTAEKLQVFEKLTFEQLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIH 764
W+ E + + +T +L FIP + ++ E L+HGNI + AL + +++ + + H
Sbjct: 670 WTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAH 729
Query: 765 N---LQVSNNRLRSYLLPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFA 821
L R R LP F Y+ ++ + N I+ Q D+ S + LF
Sbjct: 730 TKPLLPSQLVRYREVQLPDRGWFVYQQ--RNEVHNNCGIEIYYQTDMQSTSENMFLELFC 787
Query: 822 QLIHEPCFDTLRTKEQLGYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQ 881
Q+I EPCF+TLRTKEQLGY+VFS +G +R +IQSE YLE R+ F T +
Sbjct: 788 QIISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEK 847
Query: 882 VLRDMPEEDFEKHKEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANIT 941
+ DM EE F+KH +AL L K K ++ E A+Y I YNF + + +T
Sbjct: 848 SIEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLT 907
Query: 942 KQQMIDFYENYIM--SENASKLILHLKSQ------VENKELNENELDTAK---YPTGQLI 990
K+ +I FY+ + + K+ +H+ ++ V + +N+++ ++ P ++I
Sbjct: 908 KEDIIKFYKEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVI 967
Query: 991 EDVGAFKSTLFVAPVRQPMKDF 1012
+++ FK L + P+ +P +F
Sbjct: 968 QNMTEFKRGLPLFPLVKPHINF 989
>ref|XP_681313.1| hypothetical protein AN8044.2 [Aspergillus nidulans FGSC A4]
gb|EAA59666.1| hypothetical protein AN8044.2 [Aspergillus nidulans FGSC A4]
Length = 1100
Score = 1082 bits (2800), Expect = 0.0, Method: Composition-based stats.
Identities = 391/980 (39%), Positives = 570/980 (58%), Gaps = 45/980 (4%)
Query: 53 MTSNFKTFNLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKN 112
+ + KP LD+RSYR I+LPNKL+ALL+ DP+ DKAAA++DV++G+F DP +
Sbjct: 2 TMRSAERLTEGLEKPSLDDRSYRVIQLPNKLEALLVHDPETDKAAAAMDVHVGSFSDPAD 61
Query: 113 LPGLAHFCEHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVN-------- 164
L GLAH EH+LFMG+EK+P EN Y+ YL+ H GSSNAYTA TNYFFEV+
Sbjct: 62 LQGLAHGLEHMLFMGTEKYPVENAYNQYLASHSGSSNAYTAGTETNYFFEVSATGATGES 121
Query: 165 ---------------------HQHLFGALDRFSGFFSCPLFNKDSTDKEINAVNSENKKN 203
L+GALDRF+ FF PLF +++ D+E+ AV+SENKKN
Sbjct: 122 SGQVTPNGTTNGTSAESKSNGPSPLYGALDRFAQFFISPLFLENTLDREMQAVDSENKKN 181
Query: 204 LQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGTLPKENGLNVRDELLKFHKNFYSANL 263
LQ+D+WR+ QL+KSL+N HPY+ FSTGN++TL P++ G+ +R+E +KF++ YSAN
Sbjct: 182 LQSDLWRLMQLNKSLSNPDHPYNHFSTGNLQTLKEEPQKRGVEIRNEFMKFYEKHYSANR 241
Query: 264 MKLCILGREDLDTLSDWTYDLFKDVANNGREVPLYAE-PIMQPEHLQKIIQVRPVKDLKK 322
MKL +LGRE LD L W +LF V+N + PI P + K I +PV D +
Sbjct: 242 MKLVVLGRESLDELEKWVSELFAGVSNKDLPQNRWDGIPIWLPNDMCKQIFAKPVMDTRS 301
Query: 323 LEISFTVPDMEEHWESKPPRILSHLIGHEGSGSLLAHLKKLGWANELSAGGHTVSKGNAF 382
++I F D E+ +ES+P R +SHLIGHEG GS+LA++K GWAN LSAG V G AF
Sbjct: 302 VDIYFPFLDEEKLYESQPSRYISHLIGHEGPGSILAYIKAKGWANGLSAGVMPVCPGAAF 361
Query: 383 FAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLPQKWIFNELQDISNATFKFKQAGSPSS 442
F V + LT GL Y+ V+ +IF+YI M+K P+ WIF E+++++ FKFKQ S
Sbjct: 362 FTVSVRLTQEGLQQYQQVVKVIFEYIAMIKEREPEAWIFEEMKNLAEVEFKFKQKSPASR 421
Query: 443 TVSSLAKCLEKDYIPVSRILAMGLLTKYEPDLLTQYTDALVPENSRVTLISRSLE--TDS 500
S L+ ++K P +L+ LL K++P+ + + L +N ++ ++++ D+
Sbjct: 422 FTSRLSSVMQKPL-PREWLLSGSLLRKFDPEAIKKALSYLREDNFKLIVVAQDYPGDWDT 480
Query: 501 AEKWYGTAYKVVDYPADLIKNMKSP------GLNPALTLPRPNEFVSTNFKVDKIDGIKP 554
EKWYGT YKV D P D + +++ L +P NEFV T V+K + +P
Sbjct: 481 KEKWYGTEYKVEDVPKDFMSGIRAALDTTPETRLKELHMPHKNEFVPTRLSVEKKEVSEP 540
Query: 555 LDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLPHTHASIINSMLSTLYTQLANDAL 614
P L+ DD +LW+KKDDRFW P+ ++++ + P A+ N + S LY +L DAL
Sbjct: 541 QKTPKLIRHDDHVRLWFKKDDRFWVPKATVFVTLRNPLVWATPANLVKSKLYCELVRDAL 600
Query: 615 KDVQYDAACADLRISFNKTNQGLAITASGFNEKLIILLTRFLQGVNSFEPKKDRFEILKD 674
+ YDA A L + + GL I+ G+N+K+ +LL + + E DRF I+K+
Sbjct: 601 VEYSYDAELAGLDYHLSASIFGLDISVGGYNDKMAVLLEKVFTSMRDLEINPDRFRIIKE 660
Query: 675 KTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKLQVFEKLTFEQLINFIPTIYEGVY 734
+ R KN Y+ PY Q+ +Y + ER W + + + E + F P I +
Sbjct: 661 RLTRSYKNAEYQQPYYQVGDYTRYLTAERGWLNEQYAAELDHIEAEDIKCFFPQILRQNH 720
Query: 735 FETLIHGNIKHEEALEVDSLIKSLIPNNIHNLQVSNNRLRSYLLPKGKTFRYETALKDSQ 794
E L HGNI E+AL + ++S++ N+ Q R+ ++P G + YE LKD
Sbjct: 721 IEVLAHGNIYKEDALRMTDTVESIL-NSRTLPQSQWYVRRNVIIPPGSDYIYERPLKDPA 779
Query: 795 NVNSCIQHVTQLDVYSED-LSALSGLFAQLIHEPCFDTLRTKEQLGYVVFSSSLNNHGTA 853
NVN CI++ + +++ L A LFAQ+ EP FD LR+KEQLGYVV+S + + T
Sbjct: 780 NVNHCIEYYLFIGSIADEVLRAKLLLFAQMTDEPAFDQLRSKEQLGYVVWSGARYSATTI 839
Query: 854 NIRILIQSEHTTPYLEWRINNFYETFGQVLRDMPEEDFEKHKEALCNSLLQKFKNMAEES 913
R++IQSE T YLE RI++F FG+ L M E++FE HK ++ N L+K KN++ E+
Sbjct: 840 GYRVIIQSERTAQYLESRIDSFLSNFGKTLETMTEDEFEGHKRSVINKRLEKLKNLSSET 899
Query: 914 ARYTAAIYLGDYNFTHRQKKAKLVANITKQQMIDFYENYI--MSENASKLILHLKSQ--V 969
+R+ + I DY+F + A V +TK ++DFY+ I S KL +HLK+Q
Sbjct: 900 SRFWSHIGSEDYDFQQNETDAARVRALTKSDILDFYKQMIDPASPTRGKLSIHLKAQAGA 959
Query: 970 ENKELNENELDTAKYPTGQL 989
EL E + + T QL
Sbjct: 960 HAVELKEQKARLLSFVTKQL 979
>ref|XP_001661876.1| metalloprotease [Aedes aegypti]
gb|EAT36161.1| metalloprotease [Aedes aegypti]
Length = 1003
Score = 1082 bits (2798), Expect = 0.0, Method: Composition-based stats.
Identities = 352/968 (36%), Positives = 557/968 (57%), Gaps = 21/968 (2%)
Query: 63 DFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNLPGLAHFCEH 122
+ K D R+YR ++L N LK LLI DP DK+AA+L V +G DP +PGLAHFCEH
Sbjct: 32 NITKSQQDSRNYRGLQLENGLKVLLISDPTTDKSAAALSVAVGHLSDPDEIPGLAHFCEH 91
Query: 123 LLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGALDRFSGFFSCP 182
+LF+G++K+ +EN+Y S+LS++GGSSNA T + T Y+F+V + L ALDRFS FF P
Sbjct: 92 MLFLGTKKYVNENDYMSFLSENGGSSNAATYADTTKYYFDVVPEKLPEALDRFSQFFIAP 151
Query: 183 LFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGTLPKE 242
LF + +T++EINAV+SE++KNL D+WRI Q++KSL + KHPY+KF TG+ +TL PK
Sbjct: 152 LFTESATEREINAVHSEHEKNLSMDVWRIRQVNKSLCDPKHPYNKFGTGSKKTLLEDPKT 211
Query: 243 NGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGREVPLYAEPI 302
+N+R+EL+KFH +YSAN+M L + G+E LD L +F ++ N P + +
Sbjct: 212 TNINIREELMKFHAKWYSANIMSLAVFGKESLDDLESMVVGMFSEIENKNVTSPEWKDLP 271
Query: 303 MQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGSGSLLAHLKK 362
+ + L +V PVKD + L I+F D+E+H+ + P SHLIGHEG+GS+L+ LK
Sbjct: 272 YKNDQLATKTKVVPVKDSRSLTITFQTEDLEQHYRAGPEHYASHLIGHEGAGSILSELKA 331
Query: 363 LGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLPQKWIFN 422
GW N L G +T+ +G FF V +DLT +G H D++ +IFQYI MLK PQKWIF
Sbjct: 332 KGWCNNLVGGYNTIGRGFGFFEVMVDLTQDGFEHVDDIVKIIFQYINMLKKEGPQKWIFE 391
Query: 423 ELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILAMGLLTKYEPDLLTQYTDAL 482
E D+ F+FK +P + VSS+ ++ Y + A L++++ PDL+ +
Sbjct: 392 EYCDLCEMQFRFKDKENPLTLVSSVVHSMQ-SYPLEEVLAAPYLISEWRPDLIEDLWNKF 450
Query: 483 VPENSRVTLISRSLETD--SAEKWYGTAYKVVDYPADLIKNMKSPGLNPALTLPRPNEFV 540
P+N+R+T++ + E E+WYGT Y A ++++ LN L LP N F+
Sbjct: 451 YPQNARITVVGQKCEAKATCEEEWYGTKYSTEKIDAKVLEDWAKSDLNGNLHLPERNPFI 510
Query: 541 STNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLPHTHASIINS 600
TNF + +D PV++ + + ++W+K+D F +P+ + L F P ++ +N
Sbjct: 511 PTNFDLLAVDA-DIESIPVIIHNTPMMRVWFKQDVEFLKPKTLMNLDFCSPIVYSDPLNC 569
Query: 601 MLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLIILLTRFLQGVN 660
L+ L+ QL D L + Y A A LR+ T G++++ G++ K ILL + L +
Sbjct: 570 NLTHLFVQLFKDHLNEYLYAAGLAGLRLGVANTTYGVSVSIGGYSHKQHILLEKVLDDMF 629
Query: 661 SFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKLQVFEKLTFE 720
+F+ + RFEILK++ IR+LKN E PY Y ++ E++WS E + E +T +
Sbjct: 630 NFKIDEKRFEILKEQYIRNLKNYQAEQPYQHAVYYLALLLTEQAWSKQELIDATELVTVD 689
Query: 721 QLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIHNLQVSNNRL----RSY 776
+L FI + ++ E I+GN+ E+ALE+ S ++ + N+ R R Y
Sbjct: 690 RLRTFIDELLSRMHVECFIYGNVNKEKALEMSSKVEDKLKKTDANVVPLLARQLMLKREY 749
Query: 777 LLPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFAQLIHEPCFDTLRTKE 836
L G+ +E + + + +SC + Q + ++ + L Q++ EPC++ LRTKE
Sbjct: 750 KLNNGENCLFE--MTNEFHKSSCAELYLQCGMQNDQANVYVDLVTQILSEPCYNQLRTKE 807
Query: 837 QLGYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVLRDMPEEDFEKHKE 896
QLGY+VF S ++G IR+++QS + ++E RI +F L +M EE+F++HKE
Sbjct: 808 QLGYIVFCGSRKSNGVQGIRVIVQSANHPAFVEERIEHFLNGMVDYLENMTEEEFKRHKE 867
Query: 897 ALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMIDFYENYIMSE 956
AL L+K K ++ + ++ I L Y+F Q + + +TKQQ++D+Y+ YI+ +
Sbjct: 868 ALAAMKLEKPKRLSSQFTKFLNEIALQQYHFNRAQVEVAFLQTLTKQQIVDYYKEYIVKD 927
Query: 957 N--ASKLILHLKSQVENKELNEN------ELDTAKYPTGQ---LIEDVGAFKSTLFVAPV 1005
L +H+ S E +++ + T T + + D+ FKST + P+
Sbjct: 928 ASLRRSLSIHVVSTAEGGAGHKDASADVAKQSTDDASTQKDFVKVGDLAGFKSTRALYPM 987
Query: 1006 RQPMKDFE 1013
QP D +
Sbjct: 988 VQPYIDIK 995
>ref|XP_001397499.1| hypothetical protein An16g01860 [Aspergillus niger]
emb|CAK42803.1| unnamed protein product [Aspergillus niger]
Length = 1167
Score = 1082 bits (2798), Expect = 0.0, Method: Composition-based stats.
Identities = 391/971 (40%), Positives = 575/971 (59%), Gaps = 26/971 (2%)
Query: 43 SRYYTTNPYNMTSNFKTFNLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDV 102
SR + + + KP+LD+RSYR I LPNKL+ALL+ DP DKA+A+++V
Sbjct: 74 SRARFFSNTATMGSIERIAEQLEKPELDDRSYRVIRLPNKLEALLVHDPDTDKASAAVNV 133
Query: 103 NIGAFEDPKNLPGLAHFCEHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFE 162
N+G F D ++PG+AH EHLLFMG++K+P EN Y+ YL+ H GSSNAYTA+ TNYFFE
Sbjct: 134 NVGNFSDADDMPGMAHAVEHLLFMGTQKYPKENAYNQYLASHSGSSNAYTAATETNYFFE 193
Query: 163 V--------NHQHLFGALDRFSGFFSCPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQL 214
+ L+GALDRF+ FF PLF + + D+E+ AV+SENKKNLQ+D+WR+ QL
Sbjct: 194 IDTPAKPNYPTSPLYGALDRFAQFFVEPLFLESTLDRELRAVDSENKKNLQSDLWRLMQL 253
Query: 215 DKSLTNTKHPYHKFSTGNIETLGTLPKENGLNVRDELLKFHKNFYSANLMKLCILGREDL 274
+K+L+N HPYH FSTGN++TL P++ GL VR E +KF++ YS+N+MKL +LGR+ L
Sbjct: 254 NKTLSNPAHPYHHFSTGNLQTLKEEPQKRGLEVRQEFIKFYQAHYSSNIMKLVVLGRDPL 313
Query: 275 DTLSDWTYDLFKDVANNGREVPLYAE-PIMQPEHLQKIIQVRPVKDLKKLEISFTVPDME 333
D + W DLFK V N + PEHL K I +PV D++ L+I F D E
Sbjct: 314 DEMEQWVGDLFKHVKNQDLPQNRWDHAQPCLPEHLGKQIFAKPVMDMRSLDIYFPFMDEE 373
Query: 334 EHWESKPPRILSHLIGHEGSGSLLAHLKKLGWANELSAGGHTVSKGNAFFAVDIDLTDNG 393
+ES+P R LSHLIGHEG GS+LA++K GWAN LSAG V G+AFF + + LT G
Sbjct: 374 SMFESQPSRYLSHLIGHEGPGSILAYIKAKGWANGLSAGVMPVCPGSAFFTISVRLTPEG 433
Query: 394 LTHYRDVIVLIFQYIEMLKNSLPQKWIFNELQDISNATFKFKQAGSPSSTVSSLAKCLEK 453
L YR+V ++F+YI M+K PQ+WIF+E+++++ F+FKQ S S L+ ++K
Sbjct: 434 LKQYREVTKVVFEYIGMIKEREPQQWIFDEMKNLAEVEFRFKQKSPASRFTSRLSSVMQK 493
Query: 454 DYIPVSRILAMGLLTKYEPDLLTQYTDALVPENSRVTLISRSLE--TDSAEKWYGTAYKV 511
Y P +L+ LL K+EP+L+ + L P+N R+ ++++ + EKWYGT YKV
Sbjct: 494 PY-PREWLLSGSLLRKFEPELVKKALSYLRPDNFRMVIVAQDYPGDWNCREKWYGTEYKV 552
Query: 512 VDYPADLIKNMKSPGLNP------ALTLPRPNEFVSTNFKVDKIDGIKPLDEPVLLLSDD 565
D P D + +++ L +P NEFV T V+K + +P P L+ DD
Sbjct: 553 EDIPQDFMDSIRKAVETSPESRLSELHMPHKNEFVPTRLSVEKKEVSEPAKTPKLIRHDD 612
Query: 566 VSKLWYKKDDRFWQPRGYIYLSFKLPHTHASIINSMLSTLYTQLANDALKDVQYDAACAD 625
+LWYKKDDRFW P+ ++++ + P A+ N + + Y++L DAL + YDA A
Sbjct: 613 HVRLWYKKDDRFWVPKATVHITLRNPLVWATPANLVKAKFYSELVRDALNEYSYDAELAG 672
Query: 626 LRISFNKTNQGLAITASGFNEKLIILLTRFLQGVNSFEPKKDRFEILKDKTIRHLKNLLY 685
L S + + GL I+ G+N+K+ +LL + L + K DRF I+K++ R+ KN Y
Sbjct: 673 LDYSLSASLFGLDISVGGYNDKMSVLLEKVLTSMRDLVVKPDRFNIIKERMTRNYKNAEY 732
Query: 686 EVPYSQMSNYYNAIINERSWSTAEKLQVFEKLTFEQLINFIPTIYEGVYFETLIHGNIKH 745
+ P+ Q+ +Y + ER+W + E + E + F P I + E L HGN+
Sbjct: 733 QQPFYQVGDYTRYLTAERTWLNEQYAAELEHIEAEDVSCFFPQILRQNHIEVLAHGNLYK 792
Query: 746 EEALEVDSLIKSLIPNNIHNLQVSNNRLRSYLLPKGKTFRYETALKDSQNVNSCIQHVTQ 805
E+AL + L++S + + R R+ +LP G + YE LKD NVN CI++
Sbjct: 793 EDALRMTDLVESTLQSRTLPESQWYVR-RNMILPPGANYIYERTLKDPANVNHCIEYYLF 851
Query: 806 LDVYSED-LSALSGLFAQLIHEPCFDTLRTKEQLGYVVFSSSLNNHGTANIRILIQSEHT 864
+ +D L A LFAQ+ EP FD LR+KEQLGYVV+S + + T R++IQSE
Sbjct: 852 IGKIDDDALRAKLLLFAQMTDEPAFDQLRSKEQLGYVVWSGARYSATTMGYRVIIQSERN 911
Query: 865 TPYLEWRINNFYETFGQVLRDMPEEDFEKHKEALCNSLLQKFKNMAEESARYTAAIYLGD 924
PYLE RI++F FG+ L++M E+DFE HK ++ N L+K KN++ E+ R+ + I
Sbjct: 912 APYLESRIDSFLTGFGKSLQNMSEQDFENHKRSVVNKRLEKLKNLSSETNRFWSHIGSEY 971
Query: 925 YNFTHRQKKAKLVANITKQQMIDFYENYI--MSENASKLILHLKSQ----VENKELNENE 978
++F + A V +T+ +I F++ ++ S +KL +HLK+Q + E +
Sbjct: 972 FDFVQNESDAANVRKLTQADLIQFFQQFVDPTSATRAKLAIHLKAQAGAHAHATKPEEQK 1031
Query: 979 LDTAKYPTGQL 989
QL
Sbjct: 1032 AQLVSLFGKQL 1042
>ref|XP_505854.1| hypothetical protein [Yarrowia lipolytica]
emb|CAG78665.1| unnamed protein product [Yarrowia lipolytica CLIB122]
Length = 1007
Score = 1080 bits (2794), Expect = 0.0, Method: Composition-based stats.
Identities = 421/1008 (41%), Positives = 613/1008 (60%), Gaps = 17/1008 (1%)
Query: 17 LLTQLVHLSPISLNFTVRRFKPFTCLSRYYTTNPYNMTSNFKTFNLDFLKPDLDERSYRF 76
L L+P + T + Y P NMT F+ KP D+R YR
Sbjct: 9 LAFSFALLTPTYITQTPDNATTPSLSPSY---PPCNMTVPFQVIESSVDKPVTDDRQYRV 65
Query: 77 IELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNLPGLAHFCEHLLFMGSEKFPDENE 136
I L N L+ALLI DP AD+A+A++DVN+G+F DP LPGLAHFCEHLLFMG+EK+P+EN+
Sbjct: 66 ITLANGLEALLIHDPDADRASAAMDVNVGSFSDPVGLPGLAHFCEHLLFMGTEKYPEEND 125
Query: 137 YSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGALDRFSGFFSCPLFNKDSTDKEINAV 196
YS+YLS+H GSSNAYTAS+ TNYFF+V H++L GA DRF+ FF PLF + D+EI AV
Sbjct: 126 YSTYLSEHSGSSNAYTASEETNYFFDVGHEYLEGAFDRFAQFFVAPLFAASAKDREIQAV 185
Query: 197 NSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGTLPKENGLNVRDELLKFHK 256
+SENKKNLQND+WR++QL++SL+N HPY++FSTGN ETL T P E G++VR+ELLKF+K
Sbjct: 186 DSENKKNLQNDMWRLFQLERSLSNPDHPYNRFSTGNYETLHTEPLEKGMDVREELLKFYK 245
Query: 257 NFYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGREVPLYAEPIMQPEHLQKIIQVRP 316
YS+N+MKL ILGRE LDTL W + V N +P Y P++ L +++ +P
Sbjct: 246 ASYSSNIMKLVILGRESLDTLQSWVVEKLSSVVNTNATLPDYGVPLLTEGELGTLVKAKP 305
Query: 317 VKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGSGSLLAHLKKLGWANELSAGGHTV 376
+ D K +E++F VPD EHWES P SHL+GHEG GS+L LK GW + S+G V
Sbjct: 306 IMDTKSIEVTFPVPDTREHWESHPGHYYSHLVGHEGPGSILFFLKNKGWVSSCSSGAVQV 365
Query: 377 SKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLPQKWIFNELQDISNATFKFKQ 436
+G F + +LTD G+ HY+DV+V IF+Y+ ML++ Q+WI++E++D++ A F+F+Q
Sbjct: 366 CRGAGVFTISCELTDAGMNHYKDVVVHIFEYLRMLRDEPVQEWIYDEMRDVALANFRFRQ 425
Query: 437 AGSPSSTVSSLAKCLEKDYIPVSRILAMGLLTKYEPDLLTQYTDALVPENSRVTLISRSL 496
+PSST S LA L+K+++P +L+ L KY P+++ + +N ++ L+ + L
Sbjct: 426 KENPSSTTSRLATVLQKNHLPRQYLLSSSLFRKYSPEVIQAFGRHFTTDNFKIFLVGQEL 485
Query: 497 ET-DSAEKWYGTAYKVVDYPADLIKNMKSPGLNPALTLPRPNEFVSTNFKVDKIDGIKPL 555
E + EKWYGT Y AD ++ +KS G NP L LP PNEF+ T+F V +P
Sbjct: 486 EGLNQTEKWYGTQYSNDKIDADWMRRVKSAGRNPDLHLPAPNEFIPTDFSVPDKRAKEPQ 545
Query: 556 DEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLPHTHASIINSMLSTLYTQLANDALK 615
P LL + D +LW+K+DD F P+ + + K P HA NS+ +TL ++ D L
Sbjct: 546 THPTLLRNTDYVRLWHKRDDTFLVPKATVRIRLKNPIGHADPFNSVKTTLLIEVVTDLLL 605
Query: 616 DVQYDAACADLRISFNKTNQGLAITASGFNEKLIILLTRFLQGVNSFEPKKDRFEILKDK 675
+ Y A A L+ + G+ I +G+N KL LL R L + +F+ + RF I+K+
Sbjct: 606 EFAYAAEIAGLKYGVLASRDGVEIDLNGYNHKLETLLERILLKIKNFDVDQSRFNIVKET 665
Query: 676 TIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKLQVFEKLTFEQLINFIPTIYEGVYF 735
+ KN Y VPY+Q++++ ++N+ +W+ EK + E+LT E +I+F+P +
Sbjct: 666 VSKTYKNFGYNVPYAQVAHHSQYLLNDHTWTVQEKREKIEQLTREDIISFVPEFLRHLQV 725
Query: 736 ETLIHGNIKHEEALEVDSLIKSLIPNNIHNLQVSNNRLRSYLLPKGKTFRYETALKDSQN 795
ETL+ GN+ E+A+ + I +++ + N RS+LLP F Y+ L+D N
Sbjct: 726 ETLVVGNLAKEDAVSISQTISNVLKPAPLSPSQLVNP-RSFLLPDSSAFHYDVDLEDKAN 784
Query: 796 VNSCIQHVTQLDVYS-EDLSALSGLFAQLIHEPCFDTLRTKEQLGYVVFSSSLNNHGTAN 854
VNS I ++ Q+ +S AL + AQ+ EP F+ LRTKEQLGYVVFS + T
Sbjct: 785 VNSVIDYMVQVGKFSNIRTRALLEVLAQIGQEPSFNQLRTKEQLGYVVFSGIKSTRTTLL 844
Query: 855 IRILIQSEHTTPYLEWRINNFYET-FGQVLRDMPEEDFEKHKEALCNSLLQKFKNMAEES 913
R+LIQSE T YLE RI N+ G ++R+M E +F+KH A+ L+K KN++EE+
Sbjct: 845 YRVLIQSEKTCSYLESRIENYLIEILGPMIRNMSEAEFDKHVAAVVAKKLEKRKNISEEA 904
Query: 914 ARYTAAIYLGDYNFTHRQKKAKLVANITKQQMIDFYENYI--MSENASKLILHLKSQVEN 971
+RY + I G Y+F K A+ + + K +++FY+ Y+ S+ SKL+++LKSQV
Sbjct: 905 SRYWSQIISGYYDFKQNFKDAEEIKTLKKADLVEFYDRYVDPASKLRSKLVINLKSQVTK 964
Query: 972 KELNENELDTAKYPTGQLIEDVGAFKSTLFVAPVRQPMKDFEISAPPK 1019
E + P I D AFK++L + P++D + PK
Sbjct: 965 DE--------GQIPNSVPIIDHAAFKNSLSMTEAPVPVEDLKNYMDPK 1004
>dbj|BAE98754.1| putative zinc protease [Arabidopsis thaliana]
Length = 970
Score = 1079 bits (2790), Expect = 0.0, Method: Composition-based stats.
Identities = 345/977 (35%), Positives = 528/977 (54%), Gaps = 19/977 (1%)
Query: 53 MTSNFKTFNLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKN 112
SN ++ LKP D R YR I L N L+ LLI DP DK AAS+ V++G+F DP+
Sbjct: 4 EKSNTTVGGVEILKPRTDNREYRMIVLKNLLQVLLISDPDTDKCAASMSVSVGSFSDPQG 63
Query: 113 LPGLAHFCEHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGAL 172
L GLAHF EH+LF SEK+P+E+ YS Y+++HGGS+NAYTAS+ TNY F+VN AL
Sbjct: 64 LEGLAHFLEHMLFYASEKYPEEDSYSKYITEHGGSTNAYTASEETNYHFDVNADCFDEAL 123
Query: 173 DRFSGFFSCPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGN 232
DRF+ FF PL + D+T +EI AV+SEN+KNL +D WRI QL K L+ HPYHKFSTGN
Sbjct: 124 DRFAQFFIKPLMSADATMREIKAVDSENQKNLLSDGWRIRQLQKHLSKEDHPYHKFSTGN 183
Query: 233 IETLGTLPKENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANNG 292
++TL P+ G++ R EL+KF++ YSAN+M L + G+E LD + D +F+++ N
Sbjct: 184 MDTLHVRPQAKGVDTRSELIKFYEEHYSANIMHLVVYGKESLDKIQDLVERMFQEIQNTN 243
Query: 293 REVPLYAEPIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEG 352
+ VP + +HLQ +++ P+K KL +S+ V H++ P + L HLIGHEG
Sbjct: 244 KVVPRFPGQPCTADHLQILVKAIPIKQGHKLGVSWPVTPSIHHYDEAPSQYLGHLIGHEG 303
Query: 353 SGSLLAHLKKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLK 412
GSL LK LGWA LSAG + +FF V IDLTD G H ++++ L+F YI++L+
Sbjct: 304 EGSLFHALKTLGWATGLSAGEGEWTLDYSFFKVSIDLTDAGHEHMQEILGLLFNYIQLLQ 363
Query: 413 NSLPQKWIFNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILAMGLLTKYEP 472
+ +WIF+EL I F ++ P S + +A ++ Y ++ L TK+ P
Sbjct: 364 QTGVCQWIFDELSAICETKFHYQDKIPPMSYIVDIASNMQ-IYPTKDWLVGSSLPTKFNP 422
Query: 473 DLLTQYTDALVPENSRVTLISRSLE--TDSAEKWYGTAYKVVDYPADLIKNMKSPGLNPA 530
++ + D L P N R+ S+ E TD AE WY TAY + + I+ +
Sbjct: 423 AIVQKVVDELSPSNFRIFWESQKFEGQTDKAEPWYNTAYSLEKITSSTIQEWVQSAPDVH 482
Query: 531 LTLPRPNEFVSTNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKL 590
L LP PN F+ T+ + D + + PVLL S+LWYK D F +P+ Y+ + F
Sbjct: 483 LHLPAPNVFIPTDLSLKDADDKETV--PVLLRKTPFSRLWYKPDTMFSKPKAYVKMDFNC 540
Query: 591 PHTHASIINSMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLII 650
P +S ++L+ ++T+L D L + Y A A L + ++ G +T G+N KL I
Sbjct: 541 PLAVSSPDAAVLTDIFTRLLMDYLNEYAYYAQVAGLYYGVSLSDNGFELTLLGYNHKLRI 600
Query: 651 LLTRFLQGVNSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEK 710
LL + + +FE K DRF ++K+ + +N + PY Q Y + I+ +++W E+
Sbjct: 601 LLETVVGKIANFEVKPDRFAVIKETVTKEYQNYKFRQPYHQAMYYCSLILQDQTWPWTEE 660
Query: 711 LQVFEKLTFEQLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLI---PNNIHNLQ 767
L V L E + F+P + + E I GN+++ EA + I+ ++ P I
Sbjct: 661 LDVLSHLEAEDVAKFVPMLLSRTFIECYIAGNVENNEAESMVKHIEDVLFNDPKPICRPL 720
Query: 768 VSNNRL--RSYLLPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFAQLIH 825
+ RL R L +G + Y + + NS + H Q+ ++ LF +
Sbjct: 721 FPSQRLTNRVVKLGEGMKYFYHQDGSNPSDENSALVHYIQVHRDDFSMNIKLQLFGLVAK 780
Query: 826 EPCFDTLRTKEQLGYVVFSSSLNNHGTANIRILIQSEHTTP-YLEWRINNFYETFGQVLR 884
+ F LRT EQLGY+ + N+ G ++ +IQS P +++ R+ + + F L
Sbjct: 781 QATFHQLRTVEQLGYITALAQRNDSGIYGVQFIIQSSVKGPGHIDSRVESLLKNFESKLY 840
Query: 885 DMPEEDFEKHKEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQ 944
+M EDF+ + AL + L+K KN+ EES Y I G F ++ + + + KQ+
Sbjct: 841 EMSNEDFKSNVTALIDMKLEKHKNLKEESRFYWREIQSGTLKFNRKEAEVSALKQLQKQE 900
Query: 945 MIDFYENYIMSENASKLILHLKSQVENKELNENELDTAKYPTGQL-IEDVGAFKSTLFVA 1003
+IDF++ YI A K L ++ ++ L E D + P+ + IED+ F+ + +
Sbjct: 901 LIDFFDEYIKVGAARKKSLSIRV-YGSQHLKEMASDKDEVPSPSVEIEDIVGFRKSQPLH 959
Query: 1004 PVRQPMKDFEISAPPKL 1020
F PKL
Sbjct: 960 G------SFRGCGQPKL 970
>ref|XP_971897.1| PREDICTED: similar to Insulin-degrading enzyme (Insulysin)
(Insulinase) (Insulin protease) [Tribolium castaneum]
Length = 977
Score = 1078 bits (2789), Expect = 0.0, Method: Composition-based stats.
Identities = 362/959 (37%), Positives = 562/959 (58%), Gaps = 13/959 (1%)
Query: 63 DFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNLPGLAHFCEH 122
+ +K D+R YR +EL N +K LL+ DP DK+AA++DVN+G DP+++ GLAHFCEH
Sbjct: 14 NIIKSQEDKRLYRGLELANHMKVLLVSDPTTDKSAAAMDVNVGFMSDPRDVYGLAHFCEH 73
Query: 123 LLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGALDRFSGFFSCP 182
+LF+G++K+P+EN+Y+ YLS+HGGSSNA T +T Y+F++ L ALDRFS FF P
Sbjct: 74 MLFLGTKKYPNENDYNKYLSEHGGSSNAATYPDHTIYYFDIVPDELNNALDRFSQFFIAP 133
Query: 183 LFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGTLPKE 242
LF + +TD+E+NAVNSE++KN+ ND+WR QLDK L + KHPYH F TGN TL TLPKE
Sbjct: 134 LFTESATDREMNAVNSEHEKNIPNDVWRKDQLDKHLADPKHPYHTFGTGNRHTLDTLPKE 193
Query: 243 NGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGREVPLYAEPI 302
+NVRDELLKFH +YS+N+M L +LG+E LD L LF +V + P + E
Sbjct: 194 KNINVRDELLKFHDKWYSSNIMCLAVLGKESLDDLEQMVVKLFSEVKDKAIAAPRWEEHP 253
Query: 303 MQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGSGSLLAHLKK 362
+ EH + + P+KD++ L I F D++E+++S P +SHL+GHEG GS+L+ LK
Sbjct: 254 FKDEHFGTCVYMYPIKDVRNLNIVFPCRDLQEYYKSSPSHYISHLMGHEGPGSILSTLKA 313
Query: 363 LGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLPQKWIFN 422
GW+N L AG +G FF V +DLT+ G+ H D++ LIFQY+ MLK PQKW+ +
Sbjct: 314 RGWSNNLVAGSRPAPRGLGFFGVTVDLTEEGIKHIDDIVELIFQYLNMLKRQGPQKWVQD 373
Query: 423 ELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILAMGLLTKYEPDLLTQYTDAL 482
E +DI N F+FK SP S ++ L L+ DY + M L +++ PD++ Q +
Sbjct: 374 ENRDIGNMLFRFKDKESPRSYIAGLVHTLQ-DYSMEDVLSCMYLFSEWRPDIIEQVWNDF 432
Query: 483 VPENSRVTLISRSLET--DSAEKWYGTAYKVVDYPADLIKNMKSPGLNPALTLPRPNEFV 540
VPE R+ ++++ E D E WYGT YKV P ++ + L+ LP NEF+
Sbjct: 433 VPEKIRIVVLAKQYENELDQVEPWYGTKYKVAKIPEKTLERWRKSELSGDFKLPEKNEFI 492
Query: 541 STNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLPHTHASIINS 600
T+F++ ID + + PV++ ++++W+K+D+ F P+ + F P + +N
Sbjct: 493 PTDFELYPID-KEVTEHPVIIQDTALTRVWFKQDETFLLPKANVMFDFVSPLAYLDPLNC 551
Query: 601 MLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLIILLTRFLQGVN 660
L+ + QL DAL + Y A A L+ T GL + G++ K I L + ++ +
Sbjct: 552 NLTHMLVQLFRDALNEYAYAAELAGLKWELINTKYGLILAIGGYSNKQHIFLDKVMEKLT 611
Query: 661 SFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKLQVFEKLTFE 720
+F+ RFEI K+ IR+LKN E PY Y A++ E SW+ E L E+LT +
Sbjct: 612 NFKIDPKRFEICKENYIRNLKNFAAEQPYQHAVYYLAALLTEHSWTKQELLATTEQLTID 671
Query: 721 QLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIHNLQVSNNRL---RSYL 777
+L FIP I ++ E LIHGN E+AL++ +++ + + ++ + +L R
Sbjct: 672 KLEAFIPQILSKMHIECLIHGNANKEKALQLVQIVEDRLLSTLNMSPLLPRQLLLNRELK 731
Query: 778 LPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFAQLIHEPCFDTLRTKEQ 837
L G + YE +++ + SCI+ Q + S++ + LFAQ++ EPCFD LRTKEQ
Sbjct: 732 LEDGCNYVYE--VQNEVHKESCIELYYQCGLQSKENNMKLELFAQIVQEPCFDILRTKEQ 789
Query: 838 LGYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVLRDMPEEDFEKHKEA 897
LGY+VFS ++G +RI++QS+ L+ RI F + L++M EE+F +H+EA
Sbjct: 790 LGYIVFSGIRRSNGVQGLRIIVQSDKHPVRLDERIEEFLKNMLSYLKNMSEEEFARHREA 849
Query: 898 LCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMIDFYENYIMSEN 957
L L+K K ++ ++ + I Y+F + + +TK+ +IDFY++ +
Sbjct: 850 LAAQRLEKPKQLSTQTNIFWGEITSQQYHFDRANVEVAYLRTLTKEDIIDFYKSLLEENA 909
Query: 958 --ASKLILHLKSQVEN--KELNENELDTAKYPTGQLIEDVGAFKSTLFVAPVRQPMKDF 1012
KL +H+ S + ++ ++ + G ++ D+ FKS+ + P+ QP +
Sbjct: 910 QFRKKLSVHVVSMADGGAGKMAASDKEYTVDSKGTVVCDITVFKSSHEMHPLVQPYINI 968
>ref|NP_181710.1| peptidase M16 family protein / insulinase family protein [Arabidopsis
thaliana]
gb|AAC02769.1| putative zinc protease [Arabidopsis thaliana]
Length = 970
Score = 1078 bits (2788), Expect = 0.0, Method: Composition-based stats.
Identities = 342/977 (35%), Positives = 526/977 (53%), Gaps = 19/977 (1%)
Query: 53 MTSNFKTFNLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKN 112
SN ++ LKP D R YR I L N L+ LLI DP DK AAS+ V++G+F DP+
Sbjct: 4 EKSNTTVGGVEILKPRTDNREYRMIVLKNLLQVLLISDPDTDKCAASMSVSVGSFSDPQG 63
Query: 113 LPGLAHFCEHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGAL 172
L GLAHF EH+LF SEK+P+E+ YS Y+++HGGS+NAYTAS+ TNY F+VN AL
Sbjct: 64 LEGLAHFLEHMLFYASEKYPEEDSYSKYITEHGGSTNAYTASEETNYHFDVNADCFDEAL 123
Query: 173 DRFSGFFSCPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGN 232
DRF+ FF PL + D+T +EI AV+SEN+KNL +D WRI QL K L+ HPYHKFSTGN
Sbjct: 124 DRFAQFFIKPLMSADATMREIKAVDSENQKNLLSDGWRIRQLQKHLSKEDHPYHKFSTGN 183
Query: 233 IETLGTLPKENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANNG 292
++TL P+ G++ R EL+KF++ YSAN+M L + G+E LD + D +F+++ N
Sbjct: 184 MDTLHVRPQAKGVDTRSELIKFYEEHYSANIMHLVVYGKESLDKIQDLVERMFQEIQNTN 243
Query: 293 REVPLYAEPIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEG 352
+ VP + +HLQ +++ P+K KL +S+ V H++ P + L HLIGHEG
Sbjct: 244 KVVPRFPGQPCTADHLQILVKAIPIKQGHKLGVSWPVTPSIHHYDEAPSQYLGHLIGHEG 303
Query: 353 SGSLLAHLKKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLK 412
GSL LK LGWA LSAG + +FF V IDLTD G H ++++ L+F YI++L+
Sbjct: 304 EGSLFHALKTLGWATGLSAGEGEWTLDYSFFKVSIDLTDAGHEHMQEILGLLFNYIQLLQ 363
Query: 413 NSLPQKWIFNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILAMGLLTKYEP 472
+ +WIF+EL I F ++ P S + +A ++ Y ++ L TK+ P
Sbjct: 364 QTGVCQWIFDELSAICETKFHYQDKIPPMSYIVDIASNMQ-IYPTKDWLVGSSLPTKFNP 422
Query: 473 DLLTQYTDALVPENSRVTLISRSLE--TDSAEKWYGTAYKVVDYPADLIKNMKSPGLNPA 530
++ + D L P N R+ S+ E TD AE WY TAY + + I+ +
Sbjct: 423 AIVQKVVDELSPSNFRIFWESQKFEGQTDKAEPWYNTAYSLEKITSSTIQEWVQSAPDVH 482
Query: 531 LTLPRPNEFVSTNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKL 590
L LP PN F+ T+ + D + + PVLL S+LWYK D F +P+ Y+ + F
Sbjct: 483 LHLPAPNVFIPTDLSLKDADDKETV--PVLLRKTPFSRLWYKPDTMFSKPKAYVKMDFNC 540
Query: 591 PHTHASIINSMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLII 650
P +S ++L+ ++T+L D L + Y A A L + ++ G +T G+N KL I
Sbjct: 541 PLAVSSPDAAVLTDIFTRLLMDYLNEYAYYAQVAGLYYGVSLSDNGFELTLLGYNHKLRI 600
Query: 651 LLTRFLQGVNSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEK 710
LL + + +FE K DRF ++K+ + +N + PY Q Y + I+ +++W E+
Sbjct: 601 LLETVVGKIANFEVKPDRFAVIKETVTKEYQNYKFRQPYHQAMYYCSLILQDQTWPWTEE 660
Query: 711 LQVFEKLTFEQLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIHN----- 765
L V L E + F+P + + E I GN+++ EA + I+ ++ N+
Sbjct: 661 LDVLSHLEAEDVAKFVPMLLSRTFIECYIAGNVENNEAESMVKHIEDVLFNDPKPICRPL 720
Query: 766 LQVSNNRLRSYLLPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFAQLIH 825
+ R L +G + Y + + NS + H Q+ ++ LF +
Sbjct: 721 FPSQHLTNRVVKLGEGMKYFYHQDGSNPSDENSALVHYIQVHRDDFSMNIKLQLFGLVAK 780
Query: 826 EPCFDTLRTKEQLGYVVFSSSLNNHGTANIRILIQSEHTTP-YLEWRINNFYETFGQVLR 884
+ F LRT EQLGY+ + N+ G ++ +IQS P +++ R+ + + F L
Sbjct: 781 QATFHQLRTVEQLGYITALAQRNDSGIYGVQFIIQSSVKGPGHIDSRVESLLKNFESKLY 840
Query: 885 DMPEEDFEKHKEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQ 944
+M EDF+ + AL + L+K KN+ EES Y I G F ++ + + + KQ+
Sbjct: 841 EMSNEDFKSNVTALIDMKLEKHKNLKEESRFYWREIQSGTLKFNRKEAEVSALKQLQKQE 900
Query: 945 MIDFYENYIMSENASKLILHLKSQVENKELNENELDTAKYPTGQL-IEDVGAFKSTLFVA 1003
+IDF++ YI A K L ++ ++ L E D + P+ + IED+ F+ + +
Sbjct: 901 LIDFFDEYIKVGAARKKSLSIRV-YGSQHLKEMASDKDEVPSPSVEIEDIVGFRKSQPLH 959
Query: 1004 PVRQPMKDFEISAPPKL 1020
F PKL
Sbjct: 960 G------SFRGCGQPKL 970
>emb|CAO23586.1| unnamed protein product [Vitis vinifera]
Length = 965
Score = 1070 bits (2768), Expect = 0.0, Method: Composition-based stats.
Identities = 329/951 (34%), Positives = 509/951 (53%), Gaps = 14/951 (1%)
Query: 63 DFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNLPGLAHFCEH 122
+ +KP D R YR I L N L+ LLI DP DKAAAS+ V++G+F DP+ PGLAHF EH
Sbjct: 7 EIVKPRTDTREYRRIVLRNSLEVLLISDPDTDKAAASMSVSVGSFCDPEGFPGLAHFLEH 66
Query: 123 LLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGALDRFSGFFSCP 182
+LF SEK+P E+ YS Y+ +HGGS+NA+T+S++TNY+F+VN ALDRF+ FF P
Sbjct: 67 MLFYASEKYPLEDSYSKYIIEHGGSTNAFTSSEHTNYYFDVNSDCFEEALDRFAQFFVKP 126
Query: 183 LFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGTLPKE 242
L + D+T +EI AV+SEN+KNL +D WR+ QL K ++ HPYHKFSTGN +TL PKE
Sbjct: 127 LMSADATTREIKAVDSENQKNLLSDAWRMCQLQKHISAEGHPYHKFSTGNWDTLEVKPKE 186
Query: 243 NGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGREVPLYAEPI 302
GL+ R EL+KF++ YSANLM L + +E LD + F+++ N R
Sbjct: 187 KGLDTRHELIKFYEEHYSANLMHLVVYTKESLDKIQSLVEHKFQEIQNKDRSNFQIPGQP 246
Query: 303 MQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGSGSLLAHLKK 362
EHLQ +++ P+K KL + + + +++ P R L HLIGHEG GSL LK
Sbjct: 247 CTSEHLQILVKTVPIKQGHKLRVIWPITPSIHNYKEGPCRYLGHLIGHEGEGSLFYILKT 306
Query: 363 LGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLPQKWIFN 422
LGWA LSAG + +FF V IDLT+ G H +D++ L+F+YI +L+ + KWIF+
Sbjct: 307 LGWATSLSAGEGDWTCEFSFFKVVIDLTEAGHEHMQDIVGLLFKYISLLQQTGVCKWIFD 366
Query: 423 ELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILAMGLLTKYEPDLLTQYTDAL 482
EL I F ++ P V +++ +E Y P ++ L +K+ PD++ + D L
Sbjct: 367 ELSAICETVFHYQDKIPPIDYVVNVSSNME-LYPPKDWLVGSSLPSKFSPDVIQKVLDEL 425
Query: 483 VPENSRVTLISRSLETDS--AEKWYGTAYKVVDYPADLIKNMKSPGLNPALTLPRPNEFV 540
P N R+ S++ E + E WYGTAY + + +I+ N L LP PN F+
Sbjct: 426 APNNVRIFWESKNFEGHTDMVEPWYGTAYSIEKITSSMIQQWMLAAPNEHLHLPSPNVFI 485
Query: 541 STNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLPHTHASIINS 600
T+ + D + PVLL S LWYK D F P+ Y+ + F P +S
Sbjct: 486 PTDLSLK--DVQEKAKFPVLLRKSSYSTLWYKPDTMFSTPKAYVKIDFNCPFASSSPEAD 543
Query: 601 MLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLIILLTRFLQGVN 660
+L+ ++T+L D L + Y A A L N T+ G + +G+N KL ILL ++ +
Sbjct: 544 VLTDIFTRLLMDYLNEYAYYAQVAGLYYGINHTDSGFQVAVTGYNHKLRILLETVVEKIA 603
Query: 661 SFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKLQVFEKLTFE 720
+F+ K DRF ++K+ + +N ++ PY Q Y + I+ + +W + L+V L +
Sbjct: 604 NFKVKPDRFLVIKEMVTKEYQNFKFQQPYQQAMYYCSLILQDNTWPWMDGLEVIPHLEAD 663
Query: 721 QLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIHNLQVSNNRL-----RS 775
L F+P + + + I GNI+ +EA + I+ + + H + R
Sbjct: 664 DLAKFVPMLLSRAFLDCYIAGNIEPKEAESMIHHIEDIFYSGPHPISQPLFPSQYLTNRV 723
Query: 776 YLLPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFAQLIHEPCFDTLRTK 835
L +G ++ Y + + NS + H Q+ + LFA + + F LR+
Sbjct: 724 IKLDRGMSYFYPAEGLNPSDENSALVHYIQVHRDDFLPNVKLQLFALIAKQRAFHQLRSV 783
Query: 836 EQLGYVVFSSSLNNHGTANIRILIQSEHTTP-YLEWRINNFYETFGQVLRDMPEEDFEKH 894
EQLGY+ N+ G ++ +IQS P +++ R+ F + F L M E++F+ +
Sbjct: 784 EQLGYITVLMQRNDSGIRGVQFIIQSTVKGPGHIDSRVVEFLKMFESKLYAMSEDEFKSN 843
Query: 895 KEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMIDFYENYIM 954
AL + L+K KN+ EES Y IY G F R+ + + +T++++IDF+ +I
Sbjct: 844 VNALIDMKLEKHKNLREESGFYWREIYDGTLKFDRREAEVAALKKLTQKELIDFFNEHIK 903
Query: 955 --SENASKLILHLKSQVENKELNENELDTAKYPTGQLIEDVGAFKSTLFVA 1003
+ L + + + E +E A P I+D+ F+ + +
Sbjct: 904 VGAPQKKTLSVRVYGGLHTSEYA-DEKKEANQPKQVKIDDIFKFRKSQPLY 953
>ref|XP_001242515.1| hypothetical protein CIMG_06411 [Coccidioides immitis RS]
gb|EAS30932.1| hypothetical protein CIMG_06411 [Coccidioides immitis RS]
Length = 1126
Score = 1062 bits (2748), Expect = 0.0, Method: Composition-based stats.
Identities = 386/978 (39%), Positives = 571/978 (58%), Gaps = 60/978 (6%)
Query: 57 FKTFNLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNLPGL 116
++ KP +D+RSYR I L NKL+ALL+ DP DKA+AS++VN+G F D ++PG+
Sbjct: 3 VESVTDSVEKPVVDDRSYRVIRLANKLEALLVHDPNTDKASASVNVNVGNFSDDDDMPGM 62
Query: 117 AHFCEHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEV------------- 163
AH EHLLFMG+EK+P EN+Y+ YL+ H G SNAYTA+ TNY+FEV
Sbjct: 63 AHAVEHLLFMGTEKYPGENDYNQYLAAHSGHSNAYTAATETNYYFEVAATSHSQPVESPQ 122
Query: 164 ---------------------------------NHQHLFGALDRFSGFFSCPLFNKDSTD 190
LFGALDRF+ FF CPLF + D
Sbjct: 123 SALPTPSENPTPLGPLVDRRSSTVEESASTTSDPESPLFGALDRFAQFFICPLFLPSTLD 182
Query: 191 KEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGTLPKENGLNVRDE 250
+E+ AV+SENKKNLQ+D WR+ QL+KSL+N KHPYH FSTGN++TL P++ GL+VR+E
Sbjct: 183 RELRAVDSENKKNLQSDPWRLLQLNKSLSNPKHPYHHFSTGNLQTLRDEPQKRGLDVREE 242
Query: 251 LLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGREVPLYAE-PIMQPEHLQ 309
++FH+ YSAN MKL +LGRE LD L W LF DV N + + P PE +Q
Sbjct: 243 FIRFHEKHYSANRMKLVVLGRESLDQLERWVVQLFSDVKNKELPQNRWDDVPPFAPEDMQ 302
Query: 310 KIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGSGSLLAHLKKLGWANEL 369
K+I +PV D + L+I F D E ++S+P R +SHLIGHEG GS+LA++K GWA EL
Sbjct: 303 KMIYAKPVMDTRSLDIFFVYQDEEHMYDSQPSRYISHLIGHEGPGSILAYIKAKGWATEL 362
Query: 370 SAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLPQKWIFNELQDISN 429
SAG V G AFF + I LT++GL H+++V ++FQYI ++K + P++WIF+E++++S
Sbjct: 363 SAGAMPVCPGAAFFNISIRLTEDGLHHHQEVAKVVFQYIALIKENPPEQWIFDEMKNLSE 422
Query: 430 ATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILAMGLLTKYEPDLLTQYTDALVPENSRV 489
F+FKQ S SSL+ ++K Y P +++ LL +++P+L+T+ L +N +
Sbjct: 423 VDFRFKQKSPASRFTSSLSSVMQKPY-PREWLISCSLLRRFDPELVTRGLSYLNADNFNI 481
Query: 490 TLISRSLE--TDSAEKWYGTAYKVVDYPADLIKNMK------SPGLNPALTLPRPNEFVS 541
LIS++ D EKWYGT Y+V P +L+ ++ S G P L LP NEFV
Sbjct: 482 ELISQTYPGDWDRREKWYGTEYRVEKVPEELLSEIRAMLESPSAGKIPELHLPHKNEFVP 541
Query: 542 TNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLPHTHASIINSM 601
T V+K + KP P L+ +D+ ++W+KKDD FW P+ + ++ + P +A+ N++
Sbjct: 542 TRLDVEKKEVDKPTQTPSLIRNDERVRVWFKKDDTFWVPKASLEITLRNPLVYATPGNNV 601
Query: 602 LSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLIILLTRFLQGVNS 661
+ LY +L DAL + YDA A L + GL ++ G+N+K+ +LL + L +
Sbjct: 602 KARLYCELVRDALTEYSYDAELAGLEYDLVPSVFGLDVSIIGYNDKMAVLLEKVLHSMKD 661
Query: 662 FEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKLQVFEKLTFEQ 721
E K DRF I+K++ R +N Y++PY Q+ NY + E+++ + + E + E
Sbjct: 662 LEVKPDRFRIVKERLTRGFRNAEYQLPYYQVGNYTRFLTAEKAFINQQLAEELEHIEAED 721
Query: 722 LINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIHNLQVSNNRLRSYLLPKG 781
+ F P + + E L HGN+ E+AL++ L++S + R R+ +LP G
Sbjct: 722 VATFFPQLLRQTHIEVLAHGNLYKEDALQLTDLVESTFKSRPLPRSQWRVR-RNMILPPG 780
Query: 782 KTFRYETALKDSQNVNSCIQHVTQLDVYSED-LSALSGLFAQLIHEPCFDTLRTKEQLGY 840
+ YE LKD N+N CI++ + ++ L A LFAQ+ EP FD LRTKEQLGY
Sbjct: 781 SNYIYEYTLKDPANINHCIEYYLFVGSLTDPVLRAKIQLFAQMASEPAFDQLRTKEQLGY 840
Query: 841 VVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVLRDMPEEDFEKHKEALCN 900
VV+S + + T R++IQSE YLE RI+ F F L DM + FE HK ++ N
Sbjct: 841 VVWSGARYSATTLGYRVIIQSERDCDYLESRIDAFLSRFANYLNDMTDSVFEAHKRSVIN 900
Query: 901 SLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMIDFYENYI--MSENA 958
L+K KN++ E+ RY + I Y++ + A+ V +TK ++++FY YI S +
Sbjct: 901 KRLEKMKNLSSETNRYWSHIGSEYYDYLQHETDAEAVRPLTKAEIVEFYRQYIDPQSPSR 960
Query: 959 SKLILHLKSQVENKELNE 976
+KL +H+K+Q +
Sbjct: 961 AKLAVHMKAQASASPVAS 978
>ref|XP_759404.1| hypothetical protein UM03257.1 [Ustilago maydis 521]
gb|EAK84184.1| hypothetical protein UM03257.1 [Ustilago maydis 521]
Length = 1292
Score = 1060 bits (2742), Expect = 0.0, Method: Composition-based stats.
Identities = 372/936 (39%), Positives = 566/936 (60%), Gaps = 15/936 (1%)
Query: 47 TTNPYNMTSNFKTFNLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGA 106
T N + + F D D+ YR + L N L+AL+IQDPK DK++A++D+ +G
Sbjct: 198 TLNGSKAAAQYAVFTKDLEVSAQDDLRYRLVRLANGLEALVIQDPKTDKSSAAMDIRVGH 257
Query: 107 FEDPKNLPGLAHFCEHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQ 166
DP+ L GLAHFCEHLLFMG++K+P ENEYS YLS H G SNAYT NTNYFF+V+
Sbjct: 258 LSDPEELQGLAHFCEHLLFMGTKKYPRENEYSEYLSNHSGGSNAYTGMDNTNYFFDVSPD 317
Query: 167 HLFGALDRFSGFFSCPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYH 226
H GALDRF+ FF PLF+ +++EI AV+SE+KKNLQ+D+WR +QLDKSL++ HPY
Sbjct: 318 HFEGALDRFAQFFLEPLFDPSCSEREIKAVDSEHKKNLQSDMWRGFQLDKSLSDPSHPYS 377
Query: 227 KFSTGNIETLGTLPKENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFK 286
F TGN +TL PK G++VRDELLKFH +YSAN+MKL +LGREDLD L+ W + F
Sbjct: 378 HFGTGNYQTLWEDPKSKGVDVRDELLKFHDQYYSANVMKLVVLGREDLDQLTSWVIEKFS 437
Query: 287 DVANNGREVPLYAEPIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSH 346
V N GRE P + + + LQK I + V+D++KL+I+F +PD H+ SKP LSH
Sbjct: 438 GVRNTGREPPQFDRSPLTTQQLQKQIFAKSVRDVRKLKIAFPIPDQGPHFRSKPGHFLSH 497
Query: 347 LIGHEGSGSLLAHLKKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQ 406
IGHEG GS+L+HLKK GW + LSAG + G FF + IDLT GL ++ V+ +F+
Sbjct: 498 FIGHEGEGSILSHLKKKGWCDRLSAGATGDANGFEFFKISIDLTQEGLDNHEKVVEAVFK 557
Query: 407 YIEMLKNSLPQKWIFNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILAMGL 466
YI +L++S ++W +E+ +S F+FK+ P+ SS A ++ Y + L
Sbjct: 558 YIHLLRSSNLEQWTHDEVAQLSELMFRFKEKIDPADYASSTATQMQMPYPREWILSGGWL 617
Query: 467 LTKYEPDLLTQYTDALVPENSRVTLISRSLE-----TDSAEKWYGTAYKVVDYPADLIKN 521
++ +L+TQ D L P+N RV +++++L +S EKWYGT Y + P L+
Sbjct: 618 TRDFDRELITQTLDHLTPQNCRVVVMAKTLPDGSTSWESKEKWYGTEYSIKPLPQQLLT- 676
Query: 522 MKSPGLNPALTLPRPNEFVSTNFK----VDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRF 577
++P L LPRPN F+ NF + + G KP P L+L ++ ++W+K DDRF
Sbjct: 677 -QTPADFEDLHLPRPNSFIPVNFDFKGPLAEAQGKKPTPRPQLVLDNESIRVWHKLDDRF 735
Query: 578 WQPRGYIYLSFKLPHTHASIINSMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGL 637
P+ ++ + P +A+ + S+ + + +L +D+L + YDA+ A L + +Q L
Sbjct: 736 GLPKANVFFVLRNPLINATPLTSIKTRMLIELISDSLVEYSYDASLAGLSYMLDSQDQSL 795
Query: 638 AITASGFNEKLIILLTRFLQGVNSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYN 697
A++ SG+N+K+ +L L+ + +F+ RFE++KD+ R +N E PY + Y
Sbjct: 796 ALSLSGYNDKIPVLARSILEKLANFQVDPRRFELVKDRVKRSYQNFAIEEPYRHATFYTT 855
Query: 698 AIINERSWSTAEKLQVFEKLTFEQLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKS 757
++ E+ W+ EKL E+L +++ F+P + + ++ E L HGN+ EEA+E+ ++ +
Sbjct: 856 YLLQEKMWTPQEKLCELEQLNVDEVQQFLPDLLQRMHLEVLAHGNLAKEEAIELSNMAWN 915
Query: 758 LIPNNIHNLQVSNNRLRSYLLPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSE-DLSAL 816
I + N + RS LLP+ + + ++ NVNS I++ Q+ ++ ++ A
Sbjct: 916 TIKSRPVN-KTELLSSRSLLLPEKSNKIWNLPVTNAANVNSAIEYYVQIGEPTDVEMRAT 974
Query: 817 SGLFAQLIHEPCFDTLRTKEQLGYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFY 876
LF+Q+ +EP FD LRTKEQLGY+VFS + G+ R+++QSE PYLE R++ F
Sbjct: 975 LSLFSQIANEPVFDQLRTKEQLGYLVFSGIRRSTGSLGWRVIVQSERDAPYLEGRVDAFL 1034
Query: 877 ETFGQVLRDMPEEDFEKHKEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKL 936
+ F L M E++FE HK ++ + L+ KN+ EES R+ + ++ G+Y+F R +
Sbjct: 1035 DQFRATLDKMTEQEFEAHKRSIIHKKLENVKNLVEESTRFWSPVFGGNYDFLARYADVEA 1094
Query: 937 VANITKQQMIDFYENYI--MSENASKLILHLKSQVE 970
+A TK+Q++D + YI S SKL +HL S
Sbjct: 1095 IAQTTKEQVVDLFMKYIHPSSPTRSKLSVHLNSTAS 1130
>ref|XP_001820380.1| hypothetical protein [Aspergillus oryzae RIB40]
dbj|BAE58378.1| unnamed protein product [Aspergillus oryzae]
Length = 1108
Score = 1060 bits (2741), Expect = 0.0, Method: Composition-based stats.
Identities = 378/977 (38%), Positives = 562/977 (57%), Gaps = 50/977 (5%)
Query: 54 TSNFKTFNLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNL 113
++ + + KP+LD+RSYR I LPNKL+ALL+ DP DKA+A+++VN+G F D ++
Sbjct: 1 MASIERITENLDKPELDDRSYRVIRLPNKLEALLVHDPDTDKASAAVNVNVGNFSDADDM 60
Query: 114 PGLAHFCEHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNH-------- 165
PG+AH EHLLFMG+EK+P EN Y+ YL+ H GSSNAYTA+ TNYFFEV+
Sbjct: 61 PGMAHAVEHLLFMGTEKYPKENAYNQYLASHSGSSNAYTAATETNYFFEVSATSESSDGS 120
Query: 166 ----------------------------QHLFGALDRFSGFFSCPLFNKDSTDKEINAVN 197
L+GALDRF+ FF PLF + + D+E+ AV+
Sbjct: 121 SSGNSTPTNGTTPTGQTESSKSPNSSKPSPLYGALDRFAQFFVAPLFLESTLDRELRAVD 180
Query: 198 SENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGTLPKENGLNVRDELLKFHKN 257
SENKKNLQ+D+WR+ QL+KSL+N HPYH FSTGN++TL P++ GLNVRDE +KF++
Sbjct: 181 SENKKNLQSDLWRLMQLNKSLSNPAHPYHHFSTGNLQTLKEEPQKRGLNVRDEFIKFYEK 240
Query: 258 FYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGREVPLYAE-PIMQPEHLQKIIQVRP 316
YS+N MKL +LGRE LD + W DLF V N + + + + K + +P
Sbjct: 241 HYSSNRMKLVVLGRETLDEMEQWVGDLFAGVKNKNLPQNRWDDVQPWLADDMCKQVFAKP 300
Query: 317 VKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGSGSLLAHLKKLGWANELSAGGHTV 376
V D + L+I F D E +ES+P R +SHLIGHEG GS+LA++K GWAN LSAG +
Sbjct: 301 VMDTRSLDIYFPFLDEEHMYESQPSRYISHLIGHEGPGSILAYVKAKGWANGLSAGVMPI 360
Query: 377 SKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLPQKWIFNELQDISNATFKFKQ 436
G+AFF V I LT GL YR+V +F+YI ++K P++WIF+E+++++ F+FKQ
Sbjct: 361 CPGSAFFTVSIRLTKEGLRQYREVAKAVFEYIALIKEREPEQWIFDEMKNLAEVEFRFKQ 420
Query: 437 AGSPSSTVSSLAKCLEKDYIPVSRILAMGLLTKYEPDLLTQYTDALVPENSRVTLISRSL 496
S S L+ ++K P +L+ LL Y+P+L+ + L +N R+ ++++
Sbjct: 421 KTPASRFTSRLSSVMQKPL-PRDWLLSGSLLRSYKPELIKKALSYLRADNFRMVVVAQDY 479
Query: 497 E--TDSAEKWYGTAYKVVDYPADLIKNMKSP------GLNPALTLPRPNEFVSTNFKVDK 548
D EKWYGT YKV D P D + ++ + L +P NEFV T V+K
Sbjct: 480 PGDWDLKEKWYGTEYKVEDVPKDFLGEIQEALKSTPETRHSDLHMPHKNEFVPTRLSVEK 539
Query: 549 IDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLPHTHASIINSMLSTLYTQ 608
+ +P P L+ DD +LW+KKDDRFW P+ ++++ + A+ N + S Y +
Sbjct: 540 KEVSEPAKTPKLIRHDDQVRLWFKKDDRFWVPKATLHVTLRNLLVWATPANLVKSKFYCE 599
Query: 609 LANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLIILLTRFLQGVNSFEPKKDR 668
L DAL + YDA A L + + + GL ++ G+N+K+ +LL + L + DR
Sbjct: 600 LVRDALVEYSYDAELAGLDYNLSASIFGLDVSVGGYNDKMAVLLEKVLTSMRDLVVNPDR 659
Query: 669 FEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKLQVFEKLTFEQLINFIPT 728
F ++K++ R KN Y+ P+ Q+ +Y + E++W + E + + F P
Sbjct: 660 FHVIKERLSRGYKNAEYQQPFYQVGDYTRYLTAEKAWLNEQYASELEHIEPNDISCFFPQ 719
Query: 729 IYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIHNLQVSNNRLRSYLLPKGKTFRYET 788
+ + E L HGN+ E+AL + ++S++ + + R R+ ++P G F YE
Sbjct: 720 LLRQNHIEVLAHGNLYKEDALRMTDSVESILQSRPLPQSQWHVR-RNVIIPPGSDFVYER 778
Query: 789 ALKDSQNVNSCIQHVTQLDVYSED-LSALSGLFAQLIHEPCFDTLRTKEQLGYVVFSSSL 847
ALKD NVN CI++ + ++D L A LFAQ+ EP FD LR+KEQLGYVV+S +
Sbjct: 779 ALKDPANVNHCIEYYLFVGNMTDDALRAKLLLFAQMTDEPAFDQLRSKEQLGYVVWSGAR 838
Query: 848 NNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVLRDMPEEDFEKHKEALCNSLLQKFK 907
+ T R++IQSE T YLE RIN F FG+ L +M +E+FE HK ++ N L+K K
Sbjct: 839 YSATTIGYRVIIQSERTAQYLESRINAFLSNFGKALEEMSDEEFEGHKRSVVNKRLEKLK 898
Query: 908 NMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMIDFYENYIMSE--NASKLILHL 965
N+ E+ R+ + ++F + A V ++K +I+FY+ YI E KL +HL
Sbjct: 899 NLGSETTRFWTHVGSEYFDFLQNESDAANVRTLSKSDLIEFYQQYIAPESTTRGKLSVHL 958
Query: 966 KSQVENKELNENELDTA 982
K+Q NE ++
Sbjct: 959 KAQAGADTTEPNEQNST 975
>gb|ABH09708.1| STE23-like protein [Penicillium marneffei]
Length = 1038
Score = 1058 bits (2736), Expect = 0.0, Method: Composition-based stats.
Identities = 383/1038 (36%), Positives = 582/1038 (56%), Gaps = 71/1038 (6%)
Query: 53 MTSNFKTFNLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKN 112
S KP+LD+RSYR I+L N+L+ALL+ DP DKA+AS +VN+G F D +
Sbjct: 2 TMSEVTHITDRLEKPELDDRSYRVIKLGNQLEALLVHDPDTDKASASANVNVGNFSDEEA 61
Query: 113 LPGLAHFCEHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNH------- 165
+PG+AH EHLLFMG+EK+P EN Y+ YL+ H GSSNAYT + TNYFFEV
Sbjct: 62 MPGMAHAVEHLLFMGTEKYPKENAYNQYLASHSGSSNAYTGAIETNYFFEVAATGESKSP 121
Query: 166 -----------------------QHLFGALDRFSGFFSCPLFNKDSTDKEINAVNSENKK 202
L+GALDRF+ FF PLF + + D+E+ AV+SENKK
Sbjct: 122 ESANGEKSAVSSSTTALSKDSATSPLYGALDRFAQFFIAPLFLESTLDRELRAVDSENKK 181
Query: 203 NLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGTLPKENGLNVRDELLKFHKNFYSAN 262
NLQ+D+WR+ QL+KSL+N +HPYHKFSTGN++TL P+ G+ VR + ++FHK YSAN
Sbjct: 182 NLQSDVWRLMQLNKSLSNPEHPYHKFSTGNLQTLRDDPQSRGVEVRSKFIEFHKKHYSAN 241
Query: 263 LMKLCILGREDLDTLSDWTYDLFKDVANNGREVPLYAE-PIMQPEHLQKIIQVRPVKDLK 321
MKL +LGRE LD L W +LF +V N + + + + L + +PV D +
Sbjct: 242 RMKLVVLGRESLDQLESWVVELFSEVQNKNLPQNRWDDVQPLSADQLCTQVFAKPVMDSR 301
Query: 322 KLEISFTVPDMEEHWESKPPRILSHLIGHEGSGSLLAHLKKLGWANELSAGGHTVSKGNA 381
L+I F D +E +E+ P R +SHLIGHEG GS+L+++K GWAN LSAG +V G+A
Sbjct: 302 SLDIYFPFLDEDELYETLPSRYISHLIGHEGPGSILSYIKAKGWANGLSAGAMSVGPGSA 361
Query: 382 FFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLPQKWIFNELQDISNATFKFKQAGSPS 441
FF + + LT++GLTHY++++ +IFQ+I M+K P+KWI++E+Q+++ F+FKQ S
Sbjct: 362 FFTISVRLTEDGLTHYKEIVKIIFQHIAMIKERAPEKWIYDEMQNLAEVEFRFKQKSPAS 421
Query: 442 STVSSLAKCLEKDYIPVSRILAMGLLTKYEPDLLTQYTDALVPENSRVTLISRSLE--TD 499
S L+ ++K + LL K++ DL+T+ L +N R+ ++S+ D
Sbjct: 422 RFTSRLSSVMQKPLPREWLLSGNNLLRKFDADLITKALSYLRSDNFRLMIVSQHFPGDWD 481
Query: 500 SAEKWYGTAYKVVDYPADLIKNMKSP------GLNPALTLPRPNEFVSTNFKVDKIDGIK 553
+ EKWYGT YK P D + +++ L +P NEF+ T V+K + +
Sbjct: 482 AKEKWYGTDYKEEKIPQDFLTEIRNALASAPSERVSDLHMPHKNEFIPTRLSVEKKEVAQ 541
Query: 554 PLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLPHTHASIINSMLSTLYTQLANDA 613
P P L+ DD ++WYKKDDRFW P+ ++++ + A+ N + + LY +L DA
Sbjct: 542 PAPTPKLIRLDDHVRVWYKKDDRFWVPKATVHITLRNSLVWATPANHVKAKLYCELVRDA 601
Query: 614 LKDVQYDAACADLRISFNKTNQGLAITASGFNEKLIILLTRFLQGVNSFEPKKDRFEILK 673
L + YDA A L + + + GL ++ G+N+K+ +LL + + + DRF+I+K
Sbjct: 602 LVEYSYDAELAGLDYNLSASIFGLDVSVGGYNDKMSVLLEKVVTTMRDLVVLPDRFKIIK 661
Query: 674 DKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKLQVFEKLTFEQLINFIPTIYEGV 733
++ R +N Y+ PY Q+ + + E++W + E + + + F P +
Sbjct: 662 ERLTRAYRNAEYQQPYYQVGDMTRYLTAEKTWINEQYAAELEHIEADDVAAFFPQLLRQN 721
Query: 734 YFETLIHGNIKHEEALEVDSLIKSLIPNNIHNLQVSNNRLRSYLLPKGKTFRYETALKDS 793
+ E L HGN+ E+AL++ ++++++ + + R R+ + P G + YE LKD
Sbjct: 722 HIEVLAHGNLYKEDALKMTDIVENIMRSRTLPQSQWHVR-RNIIFPPGSNYIYERQLKDP 780
Query: 794 QNVNSCIQHVTQLDVYSED-LSALSGLFAQLIHEPCFDTLRTKEQLGYVVFSSSLNNHGT 852
QNVN+CI++ + +++ L A L AQ+ EP FD LR+KEQLGYVV+S + + T
Sbjct: 781 QNVNNCIEYYLFVGKITDEVLRAKLLLLAQMTEEPAFDQLRSKEQLGYVVWSGARYSATT 840
Query: 853 ANIRILIQSEHTTPYLEWRINNFYETFGQVLRDMPEEDFEKHKEALCNSLLQKFKNMAEE 912
R++IQSE T YLE RI+NF F + L +M EE+FE HK ++ N L+K KN+ E
Sbjct: 841 IGYRVIIQSERTAQYLEGRIDNFLAQFAKTLDEMTEEEFESHKRSIINKRLEKLKNLGSE 900
Query: 913 SARYTAAIYLGDYNFTHRQKKAKLVANITKQQMIDFYENYI--MSENASKLILHLKSQ-- 968
++R+ I +NF + A V +TK ++ F+ YI SE +K+ +HL +Q
Sbjct: 901 TSRFWTHIGSEYFNFLQHEVDAATVRTLTKPDIVAFFRQYIDPSSETRAKISIHLNAQSA 960
Query: 969 ------------VENKELNENELDTAKYPTGQL------------IEDVGAFKSTLFVAP 1004
E E N+L G + I +V FK+ L V+P
Sbjct: 961 KTDELPVDTSETAEGAESLHNQLTNVSLSNGDVTTIKTTSRQPIYITNVPQFKARLPVSP 1020
Query: 1005 VRQPMKDFEISA--PPKL 1020
P+ D PKL
Sbjct: 1021 GPSPVVDLSEFGDFDPKL 1038
>gb|AAO74689.1| RE17458p [Drosophila melanogaster]
Length = 1031
Score = 1055 bits (2730), Expect = 0.0, Method: Composition-based stats.
Identities = 348/980 (35%), Positives = 555/980 (56%), Gaps = 16/980 (1%)
Query: 44 RYYTTNPYNMTSNFKTFNLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVN 103
+ T P +M + N++ K D R YR ++L N LK LLI DP D +AA+L V
Sbjct: 50 KSATRKPDSMEPILRLNNIE--KSLQDTRDYRGLQLENGLKVLLISDPNTDVSAAALSVQ 107
Query: 104 IGAFEDPKNLPGLAHFCEHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEV 163
+G DP NLPGLAHFCEH+LF+G+EK+P EN Y++YLS+ GGSSNA T T Y F V
Sbjct: 108 VGHMSDPTNLPGLAHFCEHMLFLGTEKYPHENGYTTYLSQSGGSSNAATYPLMTKYHFHV 167
Query: 164 NHQHLFGALDRFSGFFSCPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKH 223
L GALDRF+ FF PLF +T++EINAVNSE++KNL +D+WRI Q+D+ L H
Sbjct: 168 APDKLDGALDRFAQFFIAPLFTPSATEREINAVNSEHEKNLPSDLWRIKQVDRHLAKPDH 227
Query: 224 PYHKFSTGNIETLGTLPKENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYD 283
Y KF +GN TL +PK ++VRDELLKFHK +YSAN+M L ++G+E LD L +
Sbjct: 228 AYSKFGSGNKTTLSEIPKSKNIDVRDELLKFHKQWYSANIMCLAVIGKESLDELEGMVLE 287
Query: 284 LFKDVANNGREVPLYAEPIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRI 343
F ++ N +VP + E + +++ P+KD++ L ISFT D+ + ++S P
Sbjct: 288 KFSEIENKNVKVPGWPRHPYAEERYGQKVKIVPIKDIRSLTISFTTDDLTQFYKSGPDNY 347
Query: 344 LSHLIGHEGSGSLLAHLKKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVL 403
L+HLIGHEG GS+L+ L++LGW N+L AG G FF + +DLT GL H D++ +
Sbjct: 348 LTHLIGHEGKGSILSELRRLGWCNDLMAGHQNTQNGFGFFDIVVDLTQEGLEHVDDIVKI 407
Query: 404 IFQYIEMLKNSLPQKWIFNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILA 463
+FQY+EML+ P+KWIF+E ++ F+FK+ P + V+ ++ + ++A
Sbjct: 408 VFQYLEMLRKEGPKKWIFDECVKLNEMRFRFKEKEQPENLVTHAVSSMQ-IFPLEEVLIA 466
Query: 464 MGLLTKYEPDLLTQYTDALVPENSRVTLISRSLETDS--AEKWYGTAYKVVDYPADLIKN 521
L ++ PDL+ D LVP SR+ ++S+S E D AE +Y T Y + D +++
Sbjct: 467 PYLSNEWRPDLIKGLLDELVPSKSRIVIVSQSFEPDCDLAEPYYKTKYGITRVAKDTVQS 526
Query: 522 MKSPGLNPALTLPRPNEFVSTNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPR 581
++ LN L L PN F+ TNF + + P P ++L + ++W+K+D++F +P+
Sbjct: 527 WENCELNENLKLALPNSFIPTNFDISDVPADAP-KHPTIILDTPILRVWHKQDNQFNKPK 585
Query: 582 GYIYLSFKLPHTHASIINSMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITA 641
+ P + +N L+ + L D L + YDA A L++S + G+ T
Sbjct: 586 ACMTFDMSNPIAYLDPLNCNLNHMMVMLLKDQLNEYLYDAELASLKLSVMGKSCGIDFTI 645
Query: 642 SGFNEKLIILLTRFLQGVNSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIIN 701
GF++K ++LL + L + F + RF+ILK++ +R LKN E PY Y ++
Sbjct: 646 RGFSDKQVVLLEKLLDHLFDFSIDEKRFDILKEEYVRSLKNFKAEQPYQHSIYYLALLLT 705
Query: 702 ERSWSTAEKLQVFEKLTFEQLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIP- 760
E +W+ E L E +T+++++NF ++ ++ E I GN+ ++A ++ + + +
Sbjct: 706 ENAWANMELLDAMELVTYDRVLNFAKEFFQRLHTECFIFGNVTKQQATDIAGRVNTRLEA 765
Query: 761 NNIHNLQVSNNRL---RSYLLPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALS 817
N L + ++ R Y L G ++ +E + + +SC Q Q ++ + +
Sbjct: 766 TNASKLPILARQMLKKREYKLLAGDSYLFEKE--NEFHKSSCAQLYLQCGAQTDHTNIMV 823
Query: 818 GLFAQLIHEPCFDTLRTKEQLGYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYE 877
L +Q++ EPC+D LRTKEQLGY+VFS +G IRI++QS Y+E RI NF +
Sbjct: 824 NLVSQVLSEPCYDCLRTKEQLGYIVFSGVRKVNGANGIRIIVQSAKHPSYVEDRIENFLQ 883
Query: 878 TFGQVLRDMPEEDFEKHKEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLV 937
T+ QV+ DMP ++FE+HKEAL L+K K + ++ +++ I + Y+F + + ++
Sbjct: 884 TYLQVIEDMPLDEFERHKEALAVKKLEKPKTIFQQFSQFYGEIAMQTYHFEREEAEVAIL 943
Query: 938 ANITKQQMIDFYENYIMSEN--ASKLILHLKSQV--ENKELNENELDTAKYPTGQLIEDV 993
I+K +D+++ +I + L +H+ SQ EN ++ + I D+
Sbjct: 944 RKISKADFVDYFKKFIAKDGEERRVLSVHIVSQQTDENATSEAEPVEITNMERHKPISDI 1003
Query: 994 GAFKSTLFVAPVRQPMKDFE 1013
FKS + P+ P D +
Sbjct: 1004 VTFKSCKELYPIALPFLDIK 1023
>ref|XP_001603463.1| PREDICTED: similar to metalloprotease [Nasonia vitripennis]
Length = 999
Score = 1055 bits (2730), Expect = 0.0, Method: Composition-based stats.
Identities = 372/994 (37%), Positives = 566/994 (56%), Gaps = 29/994 (2%)
Query: 39 FTCLSRYYTTNPYNMTSNFKTFNLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAA 98
+ T + + + + +K D+R YR + L NKLK LLI DP DK+AA
Sbjct: 4 SKSFKKSITKHQSKEPTRY----NNIVKSPNDKRDYRGLILHNKLKVLLISDPMTDKSAA 59
Query: 99 SLDVNIGAFEDPKNLPGLAHFCEHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTN 158
SLDVN+G DPK LPGLAHFCEH+LF+G+ K+P+ N+Y+ YLS++GG+SNA T +TN
Sbjct: 60 SLDVNVGYLSDPKELPGLAHFCEHMLFLGTTKYPEVNDYNQYLSQNGGASNAATYLDHTN 119
Query: 159 YFFEVNHQHLFGALDRFSGFFSCPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSL 218
Y+F+VN L GALDRFS FF PLF + +T+KEI AV+ E++KN+ ND WR+ QLDKS
Sbjct: 120 YYFDVNPDKLEGALDRFSQFFVSPLFTESATEKEITAVHLEHEKNIANDTWRMDQLDKSS 179
Query: 219 TNTKHPYHKFSTGNIETLGTLPKENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLS 278
+ H Y KF TG+ +TL +PK+ ++VR ELL FH +YSAN+M L +LG+E LD L
Sbjct: 180 ADPSHAYSKFGTGSKDTLEVIPKQKNIDVRQELLNFHNTWYSANIMALSVLGKESLDDLE 239
Query: 279 DWTYDLFKDVANNGREVPLYAEPIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWES 338
D+F D+ N EVP + EH + + P+KD++ L I+F +PDM+EH+ +
Sbjct: 240 KMIVDMFSDIDNKNVEVPKWPAHPFTDEHFKTKWFIVPIKDIRNLNITFPIPDMQEHFRA 299
Query: 339 KPPRILSHLIGHEGSGSLLAHLKKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYR 398
P SHL+GHEG GSLL+ LK+ GW N L +G + ++G FF+V +DLT+ G+ H
Sbjct: 300 APVHYWSHLLGHEGKGSLLSTLKEKGWCNSLVSGKRSSARGFDFFSVYVDLTEEGILHVD 359
Query: 399 DVIVLIFQYIEMLKNSLPQKWIFNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPV 458
D++ + FQYI MLKN P +WIF E DI+ F+FK+ SP S V+ + L+ DY
Sbjct: 360 DIVTMTFQYINMLKNEGPVEWIFEEYSDIAKMNFRFKEKASPRSYVNVTVQSLQ-DYPIE 418
Query: 459 SRILAMGLLTKYEPDLLTQYTDALVPENSRVTLISRSLETD--SAEKWYGTAYKVVDYPA 516
+ A L T++ PDL+ + + LVPE RV +++++ E + S E WYGT YK P
Sbjct: 419 EVLSASRLFTQWRPDLINELNNYLVPEKIRVQVVAKAYEANADSVEPWYGTKYKKEKIPE 478
Query: 517 DLIKNMKSPGLNPALTLPRPNEFVSTNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDR 576
DLI+ + G + A LP NEF+ T F + I+ + P ++ + + W+K+DD
Sbjct: 479 DLIQRWNNAGTDEAFQLPEKNEFIPTKFDIKSIEKAEKF--PTIIEDNPFIRTWFKQDDE 536
Query: 577 FWQPRGYIYLSFKLPHTHASIINSMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQG 636
F P+ + F P T+ I+S ++ ++ QL D+L + Y A A L+ + + G
Sbjct: 537 FLLPKATMTFDFVSPLTYIDPISSNMTYMFVQLFRDSLNEYAYSADLAGLKWELSHSKYG 596
Query: 637 LAITASGFNEKLIILLTRFLQGVNSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYY 696
L++ +G++ KL++LL + L + +F RF ILK+ IR LKN E PY + Y
Sbjct: 597 LSLIIAGYDHKLVVLLNKILDRMVNFTIDDKRFAILKENYIRGLKNFEAEQPYQHAAYYL 656
Query: 697 NAIINERSWSTAEKLQVFEKLTFEQLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIK 756
A+++E+ W E L LT +++ FIP + ++ E LIHGNI EAL+ ++
Sbjct: 657 AALMSEQVWVKNELLNACSMLTADRVRQFIPLLMSKMHIECLIHGNITKAEALKTVKNVE 716
Query: 757 SLIPNNIHNLQVSNNR----LRSYLLPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSED 812
S + +++ +L + R LP G + YE + + + +SC Q Q + S +
Sbjct: 717 SKLISSVKDLTPLLPKQLVLYRELELPNGCHYLYE--VDNKHHKSSCTQIYYQSGMQSTE 774
Query: 813 LSALSGLFAQLIHEPCFDTLRTKEQLGYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRI 872
+ L LF Q+I EPCF+ LRTKEQLGY+VFS +G +RI++QS ++E RI
Sbjct: 775 SNMLLELFTQIISEPCFNILRTKEQLGYIVFSGIRRTNGVQGLRIIVQSNKHPQFVEERI 834
Query: 873 NNFYETFGQVLRDMPEEDFEKHKEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQK 932
+ F E+ + +M +E+F +HKE+L L+K K + +S Y I + YNF
Sbjct: 835 DAFMESMKDYITNMSDEEFNRHKESLATQRLEKPKMLTSQSGIYWNEISMQQYNFDRANV 894
Query: 933 KAKLVANITKQQMIDFYENYIM--SENASKLILHLKSQVENKELNENELDTAKYP----- 985
+ + I++ Q+IDFY++ + S KL +H+ S E E+ +
Sbjct: 895 EVAYLKTISRSQIIDFYKDVVHSESPQRHKLSIHVVSTAEGGAAAEDVTSSTPSAEETKK 954
Query: 986 -------TGQLIEDVGAFKSTLFVAPVRQPMKDF 1012
I+D+ FK++ + P+ +P +
Sbjct: 955 TLEQAEQQPARIQDILQFKTSHPLYPLVKPFNNV 988
>ref|NP_524182.2| Insulin degrading metalloproteinase CG5517-PA [Drosophila
melanogaster]
gb|AAF51584.2| CG5517-PA [Drosophila melanogaster]
Length = 1031
Score = 1055 bits (2728), Expect = 0.0, Method: Composition-based stats.
Identities = 347/980 (35%), Positives = 555/980 (56%), Gaps = 16/980 (1%)
Query: 44 RYYTTNPYNMTSNFKTFNLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVN 103
+ T P +M + N++ K D R YR ++L N LK LLI DP D +AA+L V
Sbjct: 50 KSATRKPDSMEPILRLNNIE--KSLQDTRDYRGLQLENGLKVLLISDPNTDVSAAALSVQ 107
Query: 104 IGAFEDPKNLPGLAHFCEHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEV 163
+G DP NLPGLAHFCEH+LF+G+EK+P EN Y++YLS+ GGSSNA T T Y F V
Sbjct: 108 VGHMSDPTNLPGLAHFCEHMLFLGTEKYPHENGYTTYLSQSGGSSNAATYPLMTKYHFHV 167
Query: 164 NHQHLFGALDRFSGFFSCPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKH 223
L GALDRF+ FF PLF +T++EINAVNSE++KNL +D+WRI Q+++ L H
Sbjct: 168 APDKLDGALDRFAQFFIAPLFTPSATEREINAVNSEHEKNLPSDLWRIKQVNRHLAKPDH 227
Query: 224 PYHKFSTGNIETLGTLPKENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYD 283
Y KF +GN TL +PK ++VRDELLKFHK +YSAN+M L ++G+E LD L +
Sbjct: 228 AYSKFGSGNKTTLSEIPKSKNIDVRDELLKFHKQWYSANIMCLAVIGKESLDELEGMVLE 287
Query: 284 LFKDVANNGREVPLYAEPIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRI 343
F ++ N +VP + E + +++ P+KD++ L ISFT D+ + ++S P
Sbjct: 288 KFSEIENKNVKVPGWPRHPYAEERYGQKVKIVPIKDIRSLTISFTTDDLTQFYKSGPDNY 347
Query: 344 LSHLIGHEGSGSLLAHLKKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVL 403
L+HLIGHEG GS+L+ L++LGW N+L AG G FF + +DLT GL H D++ +
Sbjct: 348 LTHLIGHEGKGSILSELRRLGWCNDLMAGHQNTQNGFGFFDIVVDLTQEGLEHVDDIVKI 407
Query: 404 IFQYIEMLKNSLPQKWIFNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILA 463
+FQY+EML+ P+KWIF+E ++ F+FK+ P + V+ ++ + ++A
Sbjct: 408 VFQYLEMLRKEGPKKWIFDECVKLNEMRFRFKEKEQPENLVTHAVSSMQ-IFPLEEVLIA 466
Query: 464 MGLLTKYEPDLLTQYTDALVPENSRVTLISRSLETDS--AEKWYGTAYKVVDYPADLIKN 521
L ++ PDL+ D LVP SR+ ++S+S E D AE +Y T Y + D +++
Sbjct: 467 PYLSNEWRPDLIKGLLDELVPSKSRIVIVSQSFEPDCDLAEPYYKTKYGITRVAKDTVQS 526
Query: 522 MKSPGLNPALTLPRPNEFVSTNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPR 581
++ LN L L PN F+ TNF + + P P ++L + ++W+K+D++F +P+
Sbjct: 527 WENCELNENLKLALPNSFIPTNFDISDVPADAP-KHPTIILDTPILRVWHKQDNQFNKPK 585
Query: 582 GYIYLSFKLPHTHASIINSMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITA 641
+ P + +N L+ + L D L + YDA A L++S + G+ T
Sbjct: 586 ACMTFDMSNPIAYLDPLNCNLNHMMVMLLKDQLNEYLYDAELASLKLSVMGKSCGIDFTI 645
Query: 642 SGFNEKLIILLTRFLQGVNSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIIN 701
GF++K ++LL + L + F + RF+ILK++ +R LKN E PY Y ++
Sbjct: 646 RGFSDKQVVLLEKLLDHLFDFSIDEKRFDILKEEYVRSLKNFKAEQPYQHSIYYLALLLT 705
Query: 702 ERSWSTAEKLQVFEKLTFEQLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIP- 760
E +W+ E L E +T+++++NF ++ ++ E I GN+ ++A ++ + + +
Sbjct: 706 ENAWANMELLDAMELVTYDRVLNFAKEFFQRLHTECFIFGNVTKQQATDIAGRVNTRLEA 765
Query: 761 NNIHNLQVSNNRL---RSYLLPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALS 817
N L + ++ R Y L G ++ +E + + +SC Q Q ++ + +
Sbjct: 766 TNASKLPILARQMLKKREYKLLAGDSYLFEKE--NEFHKSSCAQLYLQCGAQTDHTNIMV 823
Query: 818 GLFAQLIHEPCFDTLRTKEQLGYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYE 877
L +Q++ EPC+D LRTKEQLGY+VFS +G IRI++QS Y+E RI NF +
Sbjct: 824 NLVSQVLSEPCYDCLRTKEQLGYIVFSGVRKVNGANGIRIIVQSAKHPSYVEDRIENFLQ 883
Query: 878 TFGQVLRDMPEEDFEKHKEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLV 937
T+ QV+ DMP ++FE+HKEAL L+K K + ++ +++ I + Y+F + + ++
Sbjct: 884 TYLQVIEDMPLDEFERHKEALAVKKLEKPKTIFQQFSQFYGEIAMQTYHFEREEAEVAIL 943
Query: 938 ANITKQQMIDFYENYIMSEN--ASKLILHLKSQV--ENKELNENELDTAKYPTGQLIEDV 993
I+K +D+++ +I + L +H+ SQ EN ++ + I D+
Sbjct: 944 RKISKADFVDYFKKFIAKDGEERRVLSVHIVSQQTDENATSEAEPVEITNMERHKPISDI 1003
Query: 994 GAFKSTLFVAPVRQPMKDFE 1013
FKS + P+ P D +
Sbjct: 1004 VTFKSCKELYPIALPFLDIK 1023
>gb|EEH46323.1| insulin-degrading enzyme [Paracoccidioides brasiliensis Pb18]
Length = 1374
Score = 1054 bits (2725), Expect = 0.0, Method: Composition-based stats.
Identities = 374/967 (38%), Positives = 554/967 (57%), Gaps = 63/967 (6%)
Query: 64 FLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNLPGLAHFCEHL 123
KP +D+RSYR I LPNKL+ALL+ DP DKA+AS++VN+G F D +LPG+AH EH
Sbjct: 11 LEKPSVDDRSYRVIRLPNKLEALLVHDPDTDKASASVNVNVGNFSDDDDLPGIAHAVEHA 70
Query: 124 LFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQH---------------- 167
LFMG+EK+P EN Y+ YL+ H G SNAYTA+ TNY+FEV
Sbjct: 71 LFMGTEKYPKENAYNQYLAAHSGYSNAYTAATETNYYFEVAATATSQSKSSPEIPPATAA 130
Query: 168 ----------------------------------LFGALDRFSGFFSCPLFNKDSTDKEI 193
L+GALDRF+ FF PLF + + D+E+
Sbjct: 131 FPAEVEPLTDGLSKPPFPSIADSAASSSNDLVPPLYGALDRFAQFFIAPLFLESTLDREL 190
Query: 194 NAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGTLPKENGLNVRDELLK 253
AV+SENKKNLQND WR+ QL+KSL+N KHPYH FSTGN++TL P+ G+NVRDE ++
Sbjct: 191 RAVDSENKKNLQNDAWRLLQLNKSLSNPKHPYHHFSTGNLKTLRDGPQSRGINVRDEFIR 250
Query: 254 FHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGREVPLYAE-PIMQPEHLQKII 312
F++ YSAN MKL +LG+E LD L W +LF DV N + + E+LQKI
Sbjct: 251 FYETNYSANRMKLVVLGQESLDELEGWVAELFADVKNKSLPQNRWDDVQPFTSENLQKIC 310
Query: 313 QVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGSGSLLAHLKKLGWANELSAG 372
+PV D + L++ F D ++ +ESKP + +SHLIGHEG GS+LA++K GWA LSAG
Sbjct: 311 FAKPVMDSRSLDMLFPYQDEDDMYESKPSKYISHLIGHEGPGSILAYIKAKGWAYGLSAG 370
Query: 373 GHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLPQKWIFNELQDISNATF 432
+ G+A F + + LT++GL HY +++ +IFQYI ++K+ P++WIF+E+++++ F
Sbjct: 371 ALALCPGSALFTISVRLTEDGLKHYEEIVKVIFQYISLIKSRAPEEWIFDEMKNLAEVDF 430
Query: 433 KFKQAGSPSSTVSSLAKCLEKDYIPVSRILAMGLLTKYEPDLLTQYTDALVPENSRVTLI 492
KFKQ S SSL+ ++K Y + L+ K++ + + D +N + L+
Sbjct: 431 KFKQKSPASRFTSSLSSVMQKPYPREWLLSGPSLIRKFDEQAIRRGLDFFRADNFNIELV 490
Query: 493 SRSLE--TDSAEKWYGTAYKVVDYPADLIKNMK------SPGLNPALTLPRPNEFVSTNF 544
S++ DS EKWYGT Y+V +D++ ++ S P L LP NEFV T
Sbjct: 491 SQTYPGTWDSTEKWYGTEYRVEKISSDMLSQIERILQAPSNNPLPELHLPHKNEFVPTRL 550
Query: 545 KVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLPHTHASIINSMLST 604
+V+K D ++P +P L+ +DD + W+KKDD F+ P+ + ++ + P +A+ N++L+
Sbjct: 551 EVEKKDVLEPAKKPTLIRNDDRVRAWFKKDDTFFVPKATLEITLRNPLVYATPGNNVLTK 610
Query: 605 LYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLIILLTRFLQGVNSFEP 664
+ L D L++ YDA L S + + GL +T SG+N+K+ +LL + L + F+
Sbjct: 611 IACGLIRDDLQEYSYDAELGGLDYSLSASVFGLEVTVSGYNDKMAVLLEKVLHSMRDFKV 670
Query: 665 KKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKLQVFEKLTFEQLIN 724
K DRF+I+KD+ + N ++ PY Q+ N + E++W + E + E +
Sbjct: 671 KPDRFKIVKDRMTKGFSNAEFQQPYHQVGNVTRYLTAEKAWINEQLAAELEHIEAEDVAA 730
Query: 725 FIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIHNLQVSNNRLRSYLLPKGKTF 784
F P + + E L HGN+ E+ L++ LI+S + R R+ + P G F
Sbjct: 731 FFPQLLRQTHIELLGHGNLYKEDVLKMADLIESTFHARPLPKSQWHMR-RNIIFPPGSNF 789
Query: 785 RYETALKDSQNVNSCIQHVTQLDV-YSEDLSALSGLFAQLIHEPCFDTLRTKEQLGYVVF 843
YE LKD NVN CI++ + L A S LF QL +EP FD LRT+EQLGYVV+
Sbjct: 790 VYEKTLKDPANVNHCIEYYLFVGSLMDPQLRAKSLLFGQLTNEPAFDQLRTQEQLGYVVW 849
Query: 844 SSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVLRDMPEEDFEKHKEALCNSLL 903
S T R++IQS+ T YLE RI+ F F + L M E+FE HK +L N L
Sbjct: 850 SGVRYAATTLGYRVIIQSDRTNQYLETRIDAFLAGFAETLDKMTGEEFEGHKRSLINKRL 909
Query: 904 QKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMIDFYENYI--MSENASKL 961
+K KN+ E+ R+ + I ++F + A ++A ++K +MI++Y YI S +KL
Sbjct: 910 EKLKNLNSETGRFWSHIGSEYFDFLQHETDATIIAELSKAEMIEYYHQYIDPSSPTRAKL 969
Query: 962 ILHLKSQ 968
+HL +Q
Sbjct: 970 SVHLVAQ 976
>ref|NP_001060044.1| Os07g0570300 [Oryza sativa (japonica cultivar-group)]
dbj|BAC79700.1| putative insulin degrading enzyme [Oryza sativa Japonica Group]
dbj|BAF21958.1| Os07g0570300 [Oryza sativa (japonica cultivar-group)]
Length = 988
Score = 1052 bits (2722), Expect = 0.0, Method: Composition-based stats.
Identities = 330/953 (34%), Positives = 521/953 (54%), Gaps = 14/953 (1%)
Query: 61 NLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNLPGLAHFC 120
+++ +P D+R YR + LPN L+ LL+ DP DKAAAS++V++G F DP+ L GLAHF
Sbjct: 28 DVEITRPRNDKRGYRRVVLPNDLECLLVSDPDTDKAAASMNVSVGYFCDPEGLEGLAHFL 87
Query: 121 EHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGALDRFSGFFS 180
EH+LF SEK+P E+ YS Y+++HGGS+NA+T ++TN+FF+VNH L ALDRF+ FF
Sbjct: 88 EHMLFYASEKYPIEDSYSKYITEHGGSTNAFTTCEHTNFFFDVNHDCLNDALDRFAQFFI 147
Query: 181 CPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGTLP 240
PL + D+T +EI AV+SEN+KNL +D WR+ QL ++ HPYHKF TGN +TL P
Sbjct: 148 KPLLSADATLREIKAVDSENQKNLLSDPWRMNQLQNHISLESHPYHKFGTGNWDTLEVKP 207
Query: 241 KENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGREVPLYAE 300
KE GL+ R EL+KF+ + YSANLM+L + G+E LD L + F V N GRE +
Sbjct: 208 KEKGLDTRLELIKFYDSHYSANLMQLVVYGKESLDNLQTLVENKFCGVRNTGRERFSFPG 267
Query: 301 PIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGSGSLLAHL 360
EHLQ +++ P+K L I + + H++ P + +SHLIGHEG GSL L
Sbjct: 268 HPCSSEHLQVLVKAVPIKQGHTLRILWPITPNIRHYKEGPCKYVSHLIGHEGEGSLFYVL 327
Query: 361 KKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLPQKWI 420
KKLGWA L AG S +FF+V I LTD G H D++ L+F+YI +L+ S KWI
Sbjct: 328 KKLGWAMSLEAGEGDWSYEFSFFSVVIKLTDVGHEHMEDIVGLLFRYITLLQTSGTLKWI 387
Query: 421 FNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILAMGLLTKYEPDLLTQYTD 480
F+ELQ I F ++ G P V++++ ++ Y P ++A + +K+ PD + +
Sbjct: 388 FDELQTICETGFHYRDKGPPIHYVANISSNMQ-IYPPEDWLIASSVPSKFSPDAIQGILN 446
Query: 481 ALVPENSRVTLISRSLE--TDSAEKWYGTAYKVVDYPADLIKNMKSPGLNPALTLPRPNE 538
L P+N R+ S+ E T+ E WYGT+Y V P +I+ L +P+PN
Sbjct: 447 ELTPDNVRIFWESKKFEGQTNLTEPWYGTSYSVEAVPPSIIQKWVEKAPVEDLHMPKPNI 506
Query: 539 FVSTNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLPHTHASII 598
F+ ++ + + + P +L S++WYK D F+ P+ YI + F P + +S
Sbjct: 507 FLPSDLSLKNAE--EKASFPCMLRKTLFSRVWYKPDTMFFTPKAYIKMDFHCPLSRSSPE 564
Query: 599 NSMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLIILLTRFLQG 658
+S+L+ ++T+L D L D YDA A L + G IT G+N+K+ LL +
Sbjct: 565 SSVLTDVFTRLLMDYLNDYAYDAQVAGLYYGVRPNDTGFQITMVGYNDKMRTLLETVIGK 624
Query: 659 VNSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKLQVFEKLT 718
+ FE K DRF ++K+ + +N + PY Q Y + I+ E++W+ E+L ++
Sbjct: 625 IAEFEVKADRFSVIKETITKEYENFKFRQPYQQAFYYCSLILEEQTWAWDEELAAVSQIE 684
Query: 719 FEQLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLI---PNNIHNLQVSNNRL-- 773
L F+P + + E+ GN++ V ++ ++ P ++ S+ L
Sbjct: 685 ASDLEKFLPHLLGKTFIESYFAGNMEPGAVKGVMQHVEDILFNAPVSLCKALPSSQHLTK 744
Query: 774 RSYLLPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFAQLIHEPCFDTLR 833
R L +G + Y + Q+ NSC+ H Q+ + + L A + +P F LR
Sbjct: 745 RIVKLERGLRYYYPALCLNHQDENSCLLHYIQIHQDDLKKNVILQLLALVAKQPAFHQLR 804
Query: 834 TKEQLGYVVFSSSLNNHGTANIRILIQSEHTTPY-LEWRINNFYETFGQVLRDMPEEDFE 892
+ EQLGY+ N+ G ++ +IQS P L+ R+ F F L MP+ +F+
Sbjct: 805 SVEQLGYITLLRQKNDSGVRGLQFIIQSTVKDPANLDARVEAFLTMFEGTLYQMPDTEFK 864
Query: 893 KHKEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMIDFYENY 952
+ AL + L+K+KN+ EESA + I G F ++ + + ++ K+++I+F+ N+
Sbjct: 865 SNVNALIDMKLEKYKNIREESAFFWGEISEGTLKFDRKEVEVAALRDLKKEELIEFFNNH 924
Query: 953 IMSENASK--LILHLKSQVENKELNENELDTAKYPTGQLIEDVGAFKSTLFVA 1003
+ K L + + + + E + D + P I D+ F+ + +
Sbjct: 925 VKVNAPQKKILSIQVYGGLHSSEYEKIVHDEPR-PNSYQITDIFNFRRSRPLY 976
>sp|P22817|IDE_DROME Insulin-degrading enzyme (Insulysin) (Insulinase) (Insulin protease)
Length = 990
Score = 1050 bits (2717), Expect = 0.0, Method: Composition-based stats.
Identities = 347/980 (35%), Positives = 555/980 (56%), Gaps = 16/980 (1%)
Query: 44 RYYTTNPYNMTSNFKTFNLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVN 103
+ T P +M + N++ K D R YR ++L N LK LLI DP D +AA+L V
Sbjct: 9 KSATRKPDSMEPILRLNNIE--KSLQDTRDYRGLQLENGLKVLLISDPNTDVSAAALSVQ 66
Query: 104 IGAFEDPKNLPGLAHFCEHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEV 163
+G DP NLPGLAHFCEH+LF+G+EK+P EN Y++YLS+ GGSSNA T T Y F V
Sbjct: 67 VGHMSDPTNLPGLAHFCEHMLFLGTEKYPHENGYTTYLSQSGGSSNAATYPLMTKYHFHV 126
Query: 164 NHQHLFGALDRFSGFFSCPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKH 223
L GALDRF+ FF PLF +T++EINAVNSE++KNL +D+WRI Q+++ L H
Sbjct: 127 APDKLDGALDRFAQFFIAPLFTPSATEREINAVNSEHEKNLPSDLWRIKQVNRHLAKPDH 186
Query: 224 PYHKFSTGNIETLGTLPKENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYD 283
Y KF +GN TL +PK ++VRDELLKFHK +YSAN+M L ++G+E LD L +
Sbjct: 187 AYSKFGSGNKTTLSEIPKSKNIDVRDELLKFHKQWYSANIMCLAVIGKESLDELEGMVLE 246
Query: 284 LFKDVANNGREVPLYAEPIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRI 343
F ++ N +VP + E + +++ P+KD++ L ISFT D+ + ++S P
Sbjct: 247 KFSEIENKNVKVPGWPRHPYAEERYGQKVKIVPIKDIRSLTISFTTDDLTQFYKSGPDNY 306
Query: 344 LSHLIGHEGSGSLLAHLKKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVL 403
L+HLIGHEG GS+L+ L++LGW N+L AG G FF + +DLT GL H D++ +
Sbjct: 307 LTHLIGHEGKGSILSELRRLGWCNDLMAGHQNTQNGFGFFDIVVDLTQEGLEHVDDIVKI 366
Query: 404 IFQYIEMLKNSLPQKWIFNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILA 463
+FQY+EML+ P+KWIF+E ++ F+FK+ P + V+ ++ + ++A
Sbjct: 367 VFQYLEMLRKEGPKKWIFDECVKLNEMRFRFKEKEQPENLVTHAVSSMQ-IFPLEEVLIA 425
Query: 464 MGLLTKYEPDLLTQYTDALVPENSRVTLISRSLETDS--AEKWYGTAYKVVDYPADLIKN 521
L ++ PDL+ D LVP SR+ ++S+S E D AE +Y T Y + D +++
Sbjct: 426 PYLSNEWRPDLIKGLLDELVPSKSRIVIVSQSFEPDCDLAEPYYKTKYGITRVAKDTVQS 485
Query: 522 MKSPGLNPALTLPRPNEFVSTNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPR 581
++ LN L L PN F+ TNF + + P P ++L + ++W+K+D++F +P+
Sbjct: 486 WENCELNENLKLALPNSFIPTNFDISDVPADAP-KHPTIILDTPILRVWHKQDNQFNKPK 544
Query: 582 GYIYLSFKLPHTHASIINSMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITA 641
+ P + +N L+ + L D L + YDA A L++S + G+ T
Sbjct: 545 ACMTFDMSNPIAYLDPLNCNLNHMMVMLLKDQLNEYLYDAELASLKLSVMGKSCGIDFTI 604
Query: 642 SGFNEKLIILLTRFLQGVNSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIIN 701
GF++K ++LL + L + F + RF+ILK++ +R LKN E PY Y ++
Sbjct: 605 RGFSDKQVVLLEKLLDHLFDFSIDEKRFDILKEEYVRSLKNFKAEQPYQHSIYYLALLLT 664
Query: 702 ERSWSTAEKLQVFEKLTFEQLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIP- 760
E +W+ E L E +T+++++NF ++ ++ E I GN+ ++A ++ + + +
Sbjct: 665 ENAWANMELLDAMELVTYDRVLNFAKEFFQRLHTECFIFGNVTKQQATDIAGRVNTRLEA 724
Query: 761 NNIHNLQVSNNRL---RSYLLPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALS 817
N L + ++ R Y L G ++ +E + + +SC Q Q ++ + +
Sbjct: 725 TNASKLPILARQMLKKREYKLLAGDSYLFEKE--NEFHKSSCAQLYLQCGAQTDHTNIMV 782
Query: 818 GLFAQLIHEPCFDTLRTKEQLGYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYE 877
L +Q++ EPC+D LRTKEQLGY+VFS +G IRI++QS Y+E RI NF +
Sbjct: 783 NLVSQVLSEPCYDCLRTKEQLGYIVFSGVRKVNGANGIRIIVQSAKHPSYVEDRIENFLQ 842
Query: 878 TFGQVLRDMPEEDFEKHKEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLV 937
T+ QV+ DMP ++FE+HKEAL L+K K + ++ +++ I + Y+F + + ++
Sbjct: 843 TYLQVIEDMPLDEFERHKEALAVKKLEKPKTIFQQFSQFYGEIAMQTYHFEREEAEVAIL 902
Query: 938 ANITKQQMIDFYENYIMSEN--ASKLILHLKSQV--ENKELNENELDTAKYPTGQLIEDV 993
I+K +D+++ +I + L +H+ SQ EN ++ + I D+
Sbjct: 903 RKISKADFVDYFKKFIAKDGEERRVLSVHIVSQQTDENATSEAEPVEITNMERHKPISDI 962
Query: 994 GAFKSTLFVAPVRQPMKDFE 1013
FKS + P+ P D +
Sbjct: 963 VTFKSCKELYPIALPFLDIK 982
>gb|EDU43925.1| insulin-degrading enzyme [Pyrenophora tritici-repentis Pt-1C-BFP]
Length = 1098
Score = 1050 bits (2716), Expect = 0.0, Method: Composition-based stats.
Identities = 397/963 (41%), Positives = 558/963 (57%), Gaps = 36/963 (3%)
Query: 63 DFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNLPGLAHFCEH 122
D +P LD+RSYR I LPN+L+ LLI + DKA+A+LDVN+G+F D ++PG+AH EH
Sbjct: 17 DLERPQLDDRSYRIITLPNQLEVLLIHEAGTDKASAALDVNVGSFSDAPDMPGIAHAVEH 76
Query: 123 LLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNH----------------- 165
LLFMG+EK+P+EN Y+ YL++HGG SNA+TAS +TNY+FE+++
Sbjct: 77 LLFMGTEKYPEENAYNQYLTRHGGYSNAFTASTSTNYYFELSYPSSSPKSSKTPTPDASQ 136
Query: 166 ---------QHLFGALDRFSGFFSCPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDK 216
L+G LDRF FF PLF +D+ D+E+ AV+SENKKNLQND WR++QLDK
Sbjct: 137 VNLSEPKEVSPLWGGLDRFGQFFISPLFLEDTVDRELKAVDSENKKNLQNDTWRMHQLDK 196
Query: 217 SLTNTKHPYHKFSTGNIETLGTLPKENGLNVRDELLKFHKNFYSANLMKLCILGREDLDT 276
+L N HPY+ FSTG+ +TL P G+ +RDE +KFH YSAN MKL +LGRE LDT
Sbjct: 197 ALANPDHPYNHFSTGSYKTLHDEPIARGVKIRDEFIKFHSTHYSANRMKLVVLGRESLDT 256
Query: 277 LSDWTYDLFKDVANNGREVPLYAEPIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHW 336
L W ++F V N + P+ + L RPV + L+I F D E+++
Sbjct: 257 LETWVEEIFSKVPNKDLGKNRWDMPVYTEKELLTQTFARPVLQSRSLQIQFAYRDEEKYY 316
Query: 337 ESKPPRILSHLIGHEGSGSLLAHLKKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTH 396
ES P R LSHL+GHEG GS+LAH+K GWAN L AGG T+ G+ F ++I LT+ GL +
Sbjct: 317 ESHPSRYLSHLLGHEGPGSILAHIKAKGWANGLGAGGSTLCPGSGLFTINIKLTEEGLKN 376
Query: 397 YRDVIVLIFQYIEMLKNSLPQKWIFNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYI 456
Y++V L+FQYI ++ + PQ+W+ E IS F+FKQ PS T S LA +++ Y
Sbjct: 377 YKEVTKLVFQYIGLMCDKPPQEWVVEEQMRISEVEFRFKQKSPPSRTASGLAGIMQRPYE 436
Query: 457 PVSRILAMGLLTKYEPDLLTQYTDALVPENSRVTLISRSLE--TDSAEKWYGTAYKVVDY 514
+ + K++ +L+ + L P+N R+T+IS+ D EKWYGT +KV
Sbjct: 437 RKMLLSGPATIKKFDSELIREALSYLRPDNFRMTIISQDFPGGWDQKEKWYGTEHKVERI 496
Query: 515 PADLIKNMKSPGLNP----ALTLPRPNEFVSTNFKVDKIDGIKPLDEPVLLLSDDVSKLW 570
P + + +K + L P NEF+ T V+K + +P EP L+ DD ++W
Sbjct: 497 PDEFLTEIKQAFESKSRPAELHFPHKNEFIPTRLNVEKKEVEQPTKEPKLIRHDDNVRVW 556
Query: 571 YKKDDRFWQPRGYIYLSFKLPHTHASIINSMLSTLYTQLANDALKDVQYDAACADLRISF 630
+KKDD+FW P+ +++ F+ P T+ + ++L TLY +L NDAL + YDA + L F
Sbjct: 557 WKKDDQFWVPKANVHIYFRTPITNVTARITLLCTLYRELVNDALVEYAYDADISGLVYDF 616
Query: 631 NKTNQGLAITASGFNEKLIILLTRFLQGVNSFEPKKDRFEILKDKTIRHLKNLLYEVPYS 690
GL+IT SG+N+KL +LL + L V + + RF I+ D+ +R L+N Y P+
Sbjct: 617 TNHINGLSITVSGYNDKLHVLLEKVLLQVRDLKVSEGRFNIIHDRMLRSLRNWQYGQPFH 676
Query: 691 QMSNYYNAIINERSWSTAEKLQVFEKLTFEQLINFIPTIYEGVYFETLIHGNIKHEEALE 750
Q+ Y E+S E L E +T + + F P I E L HGN+ EEAL+
Sbjct: 677 QVGTYSRQFKTEKSVMNEELLPELENVTAQDVQQFFPQILAQCQIEVLAHGNLYKEEALK 736
Query: 751 VDSLIKSLIPNNIHNLQVSNNRLRSYLLPKGKTFRYETALKDSQNVNSCIQH-VTQLDVY 809
+ L++ + R R L P G F YE LKD +NVN CI++ + Y
Sbjct: 737 ITDLVERTMKPRRLPADQVPTR-RGLLWPSGCNFIYEKQLKDPENVNHCIEYSLYAGHNY 795
Query: 810 SEDLSALSGLFAQLIHEPCFDTLRTKEQLGYVVFSSSLNNHGTANIRILIQSEHTTPYLE 869
L A L Q+ EPCF+ LRT EQLGYVVFS S + + RILIQSE YLE
Sbjct: 796 DSVLRAKLLLLGQMTDEPCFNQLRTIEQLGYVVFSGSSFHDVWSGYRILIQSEKDCRYLE 855
Query: 870 WRINNFYETFGQVLRDMPEEDFEKHKEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTH 929
RI NF TF + L +M EEDFE HK+A+ N L K KN++ E R+ IY Y+F
Sbjct: 856 GRIENFLTTFEKTLNEMSEEDFESHKQAMINKRLAKLKNLSSEDNRFWNHIYSDSYDFLQ 915
Query: 930 RQKKAKLVANITKQQMIDFYENYI--MSENASKLILHLKSQVENKELNENELDTAKYPTG 987
A + +TK++M+DFY YI S + SKL +HL++Q + KE + E TA +
Sbjct: 916 ADVDAANLEKLTKKEMVDFYGRYISTSSPHRSKLSVHLQAQSKAKEPSLEEKKTAAVASL 975
Query: 988 QLI 990
++I
Sbjct: 976 KII 978
Searching..................................................done
Results from round 3
Score E
Sequences producing significant alignments: (bits) Value
Sequences used in model and found again:
gb|EDN59292.1| metalloprotease [Saccharomyces cerevisiae YJ... 1177 0.0
ref|NP_013493.2| Metalloprotease involved, with homolog Axl... 1176 0.0
ref|XP_001506502.1| PREDICTED: similar to insulin-degrading... 1156 0.0
ref|XP_001501085.1| PREDICTED: similar to insulin-degrading... 1144 0.0
ref|XP_001090249.1| PREDICTED: insulysin isoform 3 [Macaca ... 1116 0.0
ref|NP_004960.2| insulysin [Homo sapiens] >gi|55959215|emb|... 1116 0.0
ref|XP_507922.2| PREDICTED: insulysin isoform 4 [Pan troglo... 1115 0.0
ref|NP_112419.2| insulin degrading enzyme [Mus musculus] >g... 1111 0.0
ref|NP_001069317.1| insulin-degrading enzyme [Bos taurus] >... 1109 0.0
ref|XP_001090137.1| PREDICTED: insulysin isoform 2 [Macaca ... 1109 0.0
ref|XP_001146520.1| PREDICTED: insulysin isoform 2 [Pan tro... 1108 0.0
pdb|2G47|A Chain A, Crystal Structure Of Human Insulin-Degr... 1108 0.0
pdb|2JG4|A Chain A, Substrate-Free Ide Structure In Its Clo... 1107 0.0
ref|NP_037291.1| insulin degrading enzyme [Rattus norvegicu... 1106 0.0
dbj|BAF62161.1| insulin-degrading enzyme [Danio rerio] 1104 0.0
ref|XP_001146582.1| PREDICTED: insulysin isoform 3 [Pan tro... 1103 0.0
sp|Q9JHR7|IDE_MOUSE Insulin-degrading enzyme (Insulysin) (I... 1103 0.0
ref|NP_001082994.1| insulin-degrading enzyme [Danio rerio] ... 1102 0.0
gb|EDL41785.1| insulin degrading enzyme [Mus musculus] 1102 0.0
ref|XP_001276340.1| a-pheromone processing metallopeptidase... 1094 0.0
pdb|2WBY|A Chain A, Crystal Structure Of Human Insulin-Degr... 1092 0.0
sp|P14735|IDE_HUMAN Insulin-degrading enzyme (Insulysin) (I... 1091 0.0
ref|XP_001266332.1| a-pheromone processing metallopeptidase... 1087 0.0
ref|XP_001847597.1| metalloprotease [Culex pipiens quinquef... 1079 0.0
ref|XP_748141.1| a-pheromone processing metallopeptidase St... 1079 0.0
gb|EDP51051.1| a-pheromone processing metallopeptidase Ste2... 1078 0.0
ref|XP_534963.2| PREDICTED: similar to Insulin-degrading en... 1069 0.0
ref|XP_681313.1| hypothetical protein AN8044.2 [Aspergillus... 1062 0.0
ref|XP_001397499.1| hypothetical protein An16g01860 [Asperg... 1061 0.0
ref|XP_971897.1| PREDICTED: similar to Insulin-degrading en... 1060 0.0
ref|XP_001661876.1| metalloprotease [Aedes aegypti] >gi|108... 1060 0.0
emb|CAO23586.1| unnamed protein product [Vitis vinifera] 1058 0.0
ref|NP_181710.1| peptidase M16 family protein / insulinase ... 1057 0.0
dbj|BAE98754.1| putative zinc protease [Arabidopsis thaliana] 1057 0.0
gb|ABH09708.1| STE23-like protein [Penicillium marneffei] 1047 0.0
ref|XP_001646584.1| hypothetical protein Kpol_1055p83 [Vand... 1045 0.0
ref|XP_001603463.1| PREDICTED: similar to metalloprotease [... 1042 0.0
ref|NP_001060044.1| Os07g0570300 [Oryza sativa (japonica cu... 1042 0.0
emb|CAO23585.1| unnamed protein product [Vitis vinifera] 1041 0.0
ref|NP_984913.1| AER053Cp [Ashbya gossypii ATCC 10895] >gi|... 1039 0.0
ref|XP_505854.1| hypothetical protein [Yarrowia lipolytica]... 1039 0.0
ref|XP_001242515.1| hypothetical protein CIMG_06411 [Coccid... 1035 0.0
ref|XP_001820380.1| hypothetical protein [Aspergillus oryza... 1034 0.0
gb|EEH46323.1| insulin-degrading enzyme [Paracoccidioides b... 1033 0.0
ref|XP_759404.1| hypothetical protein UM03257.1 [Ustilago m... 1029 0.0
gb|AAO74689.1| RE17458p [Drosophila melanogaster] 1029 0.0
ref|NP_524182.2| Insulin degrading metalloproteinase CG5517... 1029 0.0
ref|XP_001543275.1| conserved hypothetical protein [Ajellom... 1026 0.0
emb|CAC67408.1| insulin degrading enzyme [Solanum lycopersi... 1024 0.0
ref|XP_956166.1| hypothetical protein NCU00481 [Neurospora ... 1023 0.0
sp|P22817|IDE_DROME Insulin-degrading enzyme (Insulysin) (I... 1022 0.0
ref|XP_001770543.1| predicted protein [Physcomitrella paten... 1022 0.0
dbj|BAC79699.1| putative insulin degrading enzyme [Oryza sa... 1021 0.0
ref|ZP_01258854.1| peptidase, insulinase family protein [Vi... 1020 0.0
gb|EEH33611.1| A-factor-processing enzyme [Paracoccidioides... 1019 0.0
gb|AAA28439.1| insulin-degrading enzyme 1018 0.0
gb|EDU43925.1| insulin-degrading enzyme [Pyrenophora tritic... 1017 0.0
ref|NP_798585.1| peptidase, insulinase family [Vibrio parah... 1017 0.0
gb|EAZ04397.1| hypothetical protein OsI_025629 [Oryza sativ... 1014 0.0
ref|ZP_02195786.1| peptidase, insulinase family protein [Vi... 1014 0.0
ref|NP_001044429.1| Os01g0778800 [Oryza sativa (japonica cu... 1013 0.0
gb|EAZ40359.1| hypothetical protein OsJ_023842 [Oryza sativ... 1012 0.0
ref|ZP_01474320.1| hypothetical protein VEx2w_02003082 [Vib... 1011 0.0
ref|XP_447076.1| unnamed protein product [Candida glabrata]... 1011 0.0
ref|NP_741542.1| F44E7.4b [Caenorhabditis elegans] >gi|2128... 1011 0.0
ref|XP_311589.4| AGAP010351-PA [Anopheles gambiae str. PEST... 1009 0.0
ref|XP_001801272.1| hypothetical protein SNOG_11020 [Phaeos... 1006 0.0
ref|XP_001218442.1| hypothetical protein ATEG_09820 [Asperg... 1006 0.0
ref|XP_001908020.1| unnamed protein product [Podospora anse... 1006 0.0
ref|XP_387087.1| hypothetical protein FG06911.1 [Gibberella... 1004 0.0
ref|XP_001629798.1| predicted protein [Nematostella vectens... 1004 0.0
ref|ZP_01987074.1| insulin-degrading enzyme [Vibrio harveyi... 1004 0.0
ref|NP_741543.1| F44E7.4a [Caenorhabditis elegans] >gi|2291... 1003 0.0
ref|XP_454175.1| unnamed protein product [Kluyveromyces lac... 1001 0.0
ref|XP_001590112.1| hypothetical protein SS1G_08876 [Sclero... 1000 0.0
ref|XP_001354132.1| GA18943-PA [Drosophila pseudoobscura] >... 999 0.0
ref|XP_001761886.1| predicted protein [Physcomitrella paten... 999 0.0
ref|XP_360292.2| hypothetical protein MGG_13149 [Magnaporth... 995 0.0
emb|CAB66104.1| protease-like protein [Arabidopsis thaliana] 993 0.0
ref|NP_935232.1| peptidase, insulinase family [Vibrio vulni... 993 0.0
gb|EDN12518.1| peptidase, insulinase family [Vibrio cholera... 992 0.0
ref|XP_001674236.1| Hypothetical protein CBG09322 [Caenorha... 992 0.0
ref|ZP_01978745.1| peptidase, insulinase family [Vibrio cho... 992 0.0
ref|ZP_01948940.1| peptidase, insulinase family [Vibrio cho... 992 0.0
gb|EDN15048.1| peptidase, insulinase family [Vibrio cholera... 991 0.0
ref|NP_760850.1| Peptidase [Vibrio vulnificus CMCP6] >gi|27... 991 0.0
ref|NP_231704.1| peptidase, insulinase family [Vibrio chole... 991 0.0
ref|ZP_01482660.1| hypothetical protein VchoR_02001413 [Vib... 991 0.0
ref|ZP_01956551.1| peptidase, insulinase family [Vibrio cho... 990 0.0
ref|ZP_01981574.1| peptidase, insulinase family [Vibrio cho... 990 0.0
ref|XP_001731164.1| hypothetical protein MGL_1347 [Malassez... 990 0.0
ref|YP_129176.1| putative peptidase, insulinase family [Pho... 989 0.0
ref|ZP_01478796.1| hypothetical protein VchoM_02002058 [Vib... 989 0.0
ref|ZP_01813161.1| peptidase, insulinase family protein [Vi... 989 0.0
gb|EAZ49727.1| peptidase, insulinase family [Vibrio cholera... 988 0.0
ref|ZP_01485575.1| hypothetical protein VchoV5_02001802 [Vi... 987 0.0
ref|ZP_01222787.1| putative peptidase, insulinase family pr... 981 0.0
ref|ZP_00990723.1| peptidase, insulinase family [Vibrio spl... 980 0.0
gb|EAZ04398.1| hypothetical protein OsI_025630 [Oryza sativ... 979 0.0
ref|ZP_01064420.1| peptidase, insulinase family protein [Vi... 977 0.0
ref|XP_001391726.1| hypothetical protein An07g06490 [Asperg... 974 0.0
ref|YP_001446294.1| hypothetical protein VIBHAR_03118 [Vibr... 971 0.0
gb|EAY76035.1| hypothetical protein OsI_003882 [Oryza sativ... 971 0.0
ref|NP_001023928.1| F44E7.4d [Caenorhabditis elegans] >gi|5... 970 0.0
ref|NP_504514.2| F44E7.4c [Caenorhabditis elegans] >gi|2737... 967 0.0
ref|YP_001366970.1| peptidase M16 domain protein [Shewanell... 966 0.0
ref|ZP_01235782.1| putative peptidase, insulinase family pr... 966 0.0
ref|ZP_01706404.1| peptidase M16-like [Shewanella putrefaci... 966 0.0
ref|YP_001183975.1| peptidase M16 domain protein [Shewanell... 965 0.0
ref|YP_869105.1| peptidase M16 domain protein [Shewanella s... 965 0.0
ref|YP_001051112.1| peptidase M16 domain protein [Shewanell... 964 0.0
ref|YP_001555276.1| peptidase M16 domain protein [Shewanell... 964 0.0
ref|YP_733547.1| Insulysin [Shewanella sp. MR-4] >gi|113884... 964 0.0
ref|YP_962945.1| peptidase M16 domain protein [Shewanella s... 964 0.0
ref|ZP_01866422.1| peptidase, insulinase family protein [Vi... 964 0.0
ref|YP_737533.1| peptidase M16 domain protein [Shewanella s... 963 0.0
ref|ZP_01844037.1| peptidase M16 domain protein [Shewanella... 963 0.0
ref|YP_001094545.1| peptidase M16 domain protein [Shewanell... 963 0.0
ref|ZP_01159983.1| putative peptidase, insulinase family pr... 963 0.0
ref|YP_928038.1| peptidase, M16 family [Shewanella amazonen... 962 0.0
ref|NP_507226.2| Y70C5C.1 [Caenorhabditis elegans] >gi|5808... 960 0.0
ref|ZP_02157408.1| peptidase, M16 family protein [Shewanell... 960 0.0
ref|YP_856528.1| peptidase, insulinase family [Aeromonas hy... 960 0.0
ref|YP_001674877.1| peptidase M16 domain protein [Shewanell... 958 0.0
ref|NP_718646.1| peptidase, M16 family [Shewanella oneidens... 957 0.0
dbj|BAD52843.1| putative insulin degrading enzyme [Oryza sa... 956 0.0
ref|XP_001896776.1| insulin-degrading enzyme [Brugia malayi... 956 0.0
ref|YP_001141698.1| insulinase [Aeromonas salmonicida subsp... 956 0.0
ref|YP_205192.1| protease III [Vibrio fischeri ES114] >gi|5... 955 0.0
ref|ZP_02135987.1| insulin-degrading enzyme [Vibrio fischer... 954 0.0
ref|YP_001761387.1| peptidase M16 domain protein [Shewanell... 953 0.0
ref|YP_001502447.1| peptidase M16 domain protein [Shewanell... 950 0.0
ref|YP_562541.1| peptidase M16-like protein [Shewanella den... 943 0.0
ref|XP_001763915.1| predicted protein [Physcomitrella paten... 943 0.0
ref|YP_001473373.1| peptidase M16 domain protein [Shewanell... 943 0.0
ref|XP_568105.1| insulin degrading enzyme [Cryptococcus neo... 942 0.0
ref|XP_513403.2| PREDICTED: nardilysin (N-arginine dibasic ... 941 0.0
ref|XP_773498.1| hypothetical protein CNBI1120 [Cryptococcu... 941 0.0
ref|XP_001140946.1| PREDICTED: nardilysin (N-arginine dibas... 941 0.0
emb|CAM16904.1| nardilysin, N-arginine dibasic convertase, ... 940 0.0
gb|AAH26832.1| Nardilysin, N-arginine dibasic convertase, N... 940 0.0
ref|XP_532578.2| PREDICTED: similar to nardilysin (N-argini... 940 0.0
ref|NP_666262.2| nardilysin, N-arginine dibasic convertase,... 940 0.0
ref|XP_001105075.1| PREDICTED: similar to nardilysin (N-arg... 940 0.0
ref|NP_002516.2| nardilysin (N-arginine dibasic convertase)... 940 0.0
ref|XP_859649.1| PREDICTED: similar to Nardilysin precursor... 940 0.0
emb|CAA63696.1| NRD2 convertase [Rattus sp.] 940 0.0
sp|O43847|NRDC_HUMAN Nardilysin precursor (N-arginine dibas... 939 0.0
ref|NP_001095132.1| nardilysin (N-arginine dibasic converta... 939 0.0
emb|CAA63694.1| NRD2 convertase [Homo sapiens] 939 0.0
ref|NP_037125.1| n-arginine dibasic convertase 1 [Rattus no... 939 0.0
gb|EDL90380.1| nardilysin, N-arginine dibasic convertase 1 ... 938 0.0
emb|CAA63698.1| NRD1 convertase [Homo sapiens] 938 0.0
sp|Q5R4H6|NRDC_PONPY Nardilysin precursor (N-arginine dibas... 938 0.0
ref|XP_001491329.1| PREDICTED: similar to nardilysin (N-arg... 938 0.0
ref|XP_001491380.1| PREDICTED: similar to nardilysin (N-arg... 938 0.0
gb|EAX06804.1| nardilysin (N-arginine dibasic convertase), ... 934 0.0
gb|EAX06805.1| nardilysin (N-arginine dibasic convertase), ... 933 0.0
ref|XP_001251166.1| PREDICTED: similar to NRD1 protein isof... 932 0.0
ref|XP_001251122.1| PREDICTED: similar to NRD1 protein isof... 932 0.0
ref|XP_588554.3| PREDICTED: similar to NRD1 protein isoform... 931 0.0
ref|XP_001251077.1| PREDICTED: similar to NRD1 protein isof... 931 0.0
gb|EAZ40360.1| hypothetical protein OsJ_023843 [Oryza sativ... 930 0.0
ref|XP_001491299.1| PREDICTED: similar to nardilysin (N-arg... 930 0.0
ref|XP_001491355.1| PREDICTED: similar to nardilysin (N-arg... 929 0.0
ref|XP_001140731.1| PREDICTED: nardilysin (N-arginine dibas... 929 0.0
ref|XP_001524140.1| conserved hypothetical protein [Loddero... 929 0.0
gb|EAX06808.1| nardilysin (N-arginine dibasic convertase), ... 927 0.0
gb|AAH23786.1| Nrd1 protein [Mus musculus] 927 0.0
gb|AAQ63406.1| nardilysin isoform [Homo sapiens] 926 0.0
ref|XP_719241.1| a-factor pheromone maturation protease [Ca... 924 0.0
ref|XP_001775609.1| predicted protein [Physcomitrella paten... 924 0.0
ref|NP_001038180.2| hypothetical protein LOC557565 [Danio r... 921 0.0
ref|NP_593966.1| metallopeptidase [Schizosaccharomyces pomb... 920 0.0
ref|XP_001146439.1| PREDICTED: insulysin isoform 1 [Pan tro... 920 0.0
ref|XP_001090017.1| PREDICTED: insulysin isoform 1 [Macaca ... 920 0.0
ref|YP_751350.1| peptidase M16 domain protein [Shewanella f... 918 0.0
ref|XP_001760214.1| predicted protein [Physcomitrella paten... 916 0.0
ref|NP_001118852.1| peptidase M16 family protein / insulina... 915 0.0
gb|AAC39597.1| NRD convertase [Homo sapiens] 913 0.0
ref|NP_504532.1| C02G6.1 [Caenorhabditis elegans] >gi|12801... 912 0.0
ref|XP_001140801.1| PREDICTED: nardilysin (N-arginine dibas... 912 0.0
ref|XP_001362262.1| PREDICTED: similar to nardilysin (N-arg... 911 0.0
ref|NP_001026455.1| nardilysin (N-arginine dibasic converta... 910 0.0
ref|XP_001362352.1| PREDICTED: similar to nardilysin (N-arg... 910 0.0
ref|YP_436112.1| Secreted/periplasmic Zn-dependent peptidas... 908 0.0
ref|ZP_00827012.1| COG1025: Secreted/periplasmic Zn-depende... 906 0.0
ref|XP_001383768.2| hypothetical protein PICST_56651 [Pichi... 903 0.0
ref|XP_694205.1| PREDICTED: similar to Nardilysin, N-argini... 902 0.0
ref|YP_001480039.1| peptidase M16 domain protein [Serratia ... 902 0.0
ref|YP_001007484.1| protease III precursor [Yersinia entero... 902 0.0
ref|ZP_00830096.1| COG1025: Secreted/periplasmic Zn-depende... 901 0.0
ref|ZP_00822919.1| COG1025: Secreted/periplasmic Zn-depende... 899 0.0
ref|ZP_03838288.1| hypothetical protein CATC2_19978 [Citrob... 894 0.0
ref|ZP_00834380.1| COG1025: Secreted/periplasmic Zn-depende... 894 0.0
gb|EAY76045.1| hypothetical protein OsI_003892 [Oryza sativ... 892 0.0
ref|YP_001573574.1| hypothetical protein SARI_04665 [Salmon... 891 0.0
ref|XP_456547.1| hypothetical protein DEHA0A05214g [Debaryo... 891 0.0
ref|XP_001486793.1| hypothetical protein PGUG_00170 [Pichia... 889 0.0
ref|ZP_02644586.1| protease III [Salmonella enterica subsp.... 889 0.0
ref|ZP_03833747.1| protease III precursor [Pectobacterium c... 889 0.0
ref|NP_461912.1| protease III [Salmonella typhimurium LT2] ... 888 0.0
ref|YP_001177979.1| peptidase M16 domain protein [Enterobac... 888 0.0
ref|YP_001719796.1| peptidase M16 domain protein [Yersinia ... 887 0.0
ref|ZP_02683828.1| protease III [Salmonella enterica subsp.... 887 0.0
ref|YP_217920.1| protease III [Salmonella enterica subsp. e... 886 0.0
ref|ZP_02343890.1| protease III [Salmonella enterica subsp.... 886 0.0
ref|NP_404633.1| protease III precursor [Yersinia pestis CO... 886 0.0
ref|ZP_02651766.1| protease III precursor [Salmonella enter... 886 0.0
ref|ZP_02667694.1| protease III [Salmonella enterica subsp.... 886 0.0
ref|NP_755290.1| Protease III precursor [Escherichia coli C... 885 0.0
ref|YP_311808.1| protease III [Shigella sonnei Ss046] >gi|7... 885 0.0
ref|ZP_02349797.1| protease III precursor [Salmonella enter... 885 0.0
ref|ZP_02704095.1| protease III [Salmonella enterica subsp.... 884 0.0
ref|YP_001744989.1| protease III [Escherichia coli SMS-3-5]... 884 0.0
ref|YP_542202.1| protease III precursor [Escherichia coli U... 884 0.0
ref|NP_708612.1| protease III [Shigella flexneri 2a str. 30... 884 0.0
ref|YP_049101.1| protease III precursor [Erwinia carotovora... 884 0.0
ref|ZP_00920643.1| COG1025: Secreted/periplasmic Zn-depende... 884 0.0
ref|ZP_02832280.1| protease III [Salmonella enterica subsp.... 884 0.0
ref|ZP_00923440.1| COG1025: Secreted/periplasmic Zn-depende... 884 0.0
ref|ZP_02560586.1| protease III [Salmonella enterica subsp.... 883 0.0
ref|ZP_00714851.1| COG1025: Secreted/periplasmic Zn-depende... 883 0.0
ref|YP_001464156.1| protease III [Escherichia coli E24377A]... 883 0.0
ref|ZP_00713497.1| COG1025: Secreted/periplasmic Zn-depende... 883 0.0
ref|ZP_02999194.1| protease III [Escherichia coli 53638] >g... 883 0.0
ref|ZP_02568654.1| protease III [Salmonella enterica subsp.... 883 0.0
ref|ZP_01101893.1| protease III precursor [gamma proteobact... 883 0.0
ref|NP_417298.1| protease III [Escherichia coli str. K-12 s... 883 0.0
ref|ZP_00712570.1| COG1025: Secreted/periplasmic Zn-depende... 883 0.0
gb|AAB40468.1| protease III precursor (pitrilysin) 882 0.0
pdb|1Q2L|A Chain A, Crystal Structure Of Pitrilysin 882 0.0
ref|ZP_02697767.1| protease III [Salmonella enterica subsp.... 882 0.0
ref|NP_311705.1| protease III [Escherichia coli O157:H7 str... 881 0.0
dbj|BAF01167.1| hypothetical protein [Arabidopsis thaliana] 881 0.0
ref|YP_001881438.1| protease III [Shigella boydii CDC 3083-... 881 0.0
ref|YP_002807041.1| protease III [Escherichia sp. 1_1_43] >... 881 0.0
emb|CAO77947.1| nardilysin, N-arginine dibasic convertase, ... 881 0.0
ref|YP_409069.1| protease III [Shigella boydii Sb227] >gi|8... 881 0.0
ref|NP_172173.2| metalloendopeptidase [Arabidopsis thaliana] 880 0.0
ref|ZP_02900475.1| protease III [Escherichia albertii TW076... 879 0.0
ref|NP_457388.1| protease III precursor (pitrilysin) [Salmo... 879 0.0
gb|EAY89915.1| hypothetical protein OsI_011148 [Oryza sativ... 879 0.0
ref|NP_001050040.1| Os03g0336300 [Oryza sativa (japonica cu... 879 0.0
ref|XP_001874916.1| predicted protein [Laccaria bicolor S23... 879 0.0
gb|EAZ26839.1| hypothetical protein OsJ_010322 [Oryza sativ... 878 0.0
ref|YP_001336858.1| protease III [Klebsiella pneumoniae sub... 878 0.0
ref|NP_289373.1| protease III [Escherichia coli O157:H7 EDL... 878 0.0
emb|CAO21314.1| unnamed protein product [Vitis vinifera] 877 0.0
ref|YP_404546.1| protease III [Shigella dysenteriae Sd197] ... 876 0.0
ref|YP_001455683.1| hypothetical protein CKO_04186 [Citroba... 874 0.0
ref|ZP_01896589.1| putative peptidase, insulinase family [M... 874 0.0
gb|EEH94306.1| protease III [Citrobacter sp. 30_2] 874 0.0
ref|YP_001589894.1| hypothetical protein SPAB_03726 [Salmon... 873 0.0
ref|YP_001908664.1| Protease 3 precursor (Pitrilysin) [Erwi... 869 0.0
ref|ZP_02679542.1| protease III [Salmonella enterica subsp.... 869 0.0
ref|YP_152017.1| protease III precursor (pitrilysin) [Salmo... 868 0.0
ref|XP_001833053.1| hypothetical protein CC1G_01115 [Coprin... 866 0.0
ref|YP_959771.1| peptidase M16 domain protein [Marinobacter... 862 0.0
ref|YP_001436619.1| hypothetical protein ESA_00488 [Enterob... 859 0.0
gb|EAZ13744.1| hypothetical protein OsJ_003569 [Oryza sativ... 858 0.0
ref|ZP_03829109.1| protease III precursor [Pectobacterium c... 851 0.0
ref|ZP_01892098.1| Secreted/periplasmic Zn-dependent peptid... 849 0.0
ref|ZP_01736964.1| Secreted/periplasmic Zn-dependent peptid... 847 0.0
ref|YP_268860.1| zinc metallopeptidase, M16 family [Colwell... 847 0.0
ref|ZP_01135442.1| zinc metallopeptidase, M16 family protei... 839 0.0
ref|XP_001695185.1| insulinase-like metalloprotease [Chlamy... 839 0.0
ref|XP_001599332.1| PREDICTED: similar to metalloendopeptid... 839 0.0
ref|NP_927976.1| Protease III precursor (pitrilysin) [Photo... 836 0.0
ref|ZP_02959293.1| hypothetical protein PROSTU_01129 [Provi... 834 0.0
ref|XP_001623609.1| predicted protein [Nematostella vectens... 832 0.0
ref|ZP_01616823.1| Secreted/periplasmic Zn-dependent peptid... 832 0.0
ref|YP_455654.1| protease III precursor [Sodalis glossinidi... 831 0.0
ref|XP_001649937.1| metalloprotease [Aedes aegypti] >gi|108... 831 0.0
ref|YP_339493.1| peptidase [Pseudoalteromonas haloplanktis ... 827 0.0
gb|AAF63132.1|AC011001_2 Putative N-arginine dibasic conver... 826 0.0
ref|NP_001044431.1| Os01g0779100 [Oryza sativa (japonica cu... 825 0.0
ref|ZP_01223918.1| peptidase, insulinase family protein [ma... 820 0.0
ref|ZP_01114527.1| Secreted/periplasmic Zn-dependent peptid... 819 0.0
ref|NP_567049.2| peptidase M16 family protein / insulinase ... 817 0.0
ref|YP_269852.1| zinc metallopeptidase, M16 family [Colwell... 817 0.0
emb|CAL51499.1| peptidase M16 family protein / insulinase f... 816 0.0
ref|ZP_01613408.1| protease III [Alteromonadales bacterium ... 816 0.0
ref|ZP_01307403.1| Secreted/periplasmic Zn-dependent peptid... 812 0.0
ref|XP_001434792.1| hypothetical protein GSPATT00006701001 ... 807 0.0
ref|ZP_03841633.1| pitrilysin [Proteus mirabilis ATCC 29906... 806 0.0
ref|ZP_01168295.1| zinc metallopeptidase, M16 family [Ocean... 804 0.0
ref|YP_575066.1| peptidase M16-like protein [Chromohalobact... 800 0.0
ref|XP_001031077.1| Insulysin, Insulin-degrading enzyme [Te... 800 0.0
ref|ZP_01625177.1| Secreted Zn-dependent peptidase, insulin... 799 0.0
ref|XP_001449286.1| hypothetical protein GSPATT00016702001 ... 798 0.0
ref|XP_001660612.1| metalloendopeptidase [Aedes aegypti] >g... 796 0.0
ref|XP_396981.2| PREDICTED: similar to Insulin-degrading en... 794 0.0
ref|XP_001024628.2| Insulysin, Insulin-degrading enzyme [Te... 793 0.0
ref|XP_966800.1| PREDICTED: similar to Nardilysin precursor... 793 0.0
ref|ZP_01132694.1| putative peptidase [Pseudoalteromonas tu... 790 0.0
ref|ZP_01042947.1| Secreted Zn-dependent peptidase, insulin... 789 0.0
ref|NP_504531.2| C02G6.2 [Caenorhabditis elegans] >gi|33620... 780 0.0
ref|XP_624437.2| PREDICTED: similar to Nardilysin precursor... 779 0.0
ref|XP_001844193.1| nardilysin [Culex pipiens quinquefascia... 779 0.0
Sequences not found previously or not previously below threshold:
>gb|EDN59292.1| metalloprotease [Saccharomyces cerevisiae YJM789]
Length = 1027
Score = 1177 bits (3045), Expect = 0.0, Method: Composition-based stats.
Identities = 1021/1027 (99%), Positives = 1026/1027 (99%)
Query: 1 MGVSLLASSSAFVTKPLLTQLVHLSPISLNFTVRRFKPFTCLSRYYTTNPYNMTSNFKTF 60
MGVSLLASSSAFVTKPLLTQLVH SPISLNFTVRRFKPFTCLSRYYTTNPYNMTSNFKTF
Sbjct: 1 MGVSLLASSSAFVTKPLLTQLVHFSPISLNFTVRRFKPFTCLSRYYTTNPYNMTSNFKTF 60
Query: 61 NLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNLPGLAHFC 120
NLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDP+NLPGLAHFC
Sbjct: 61 NLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPENLPGLAHFC 120
Query: 121 EHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGALDRFSGFFS 180
EHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGALDRFSGFFS
Sbjct: 121 EHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGALDRFSGFFS 180
Query: 181 CPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGTLP 240
CPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGTLP
Sbjct: 181 CPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGTLP 240
Query: 241 KENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGREVPLYAE 300
KENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLS+WTYDLFKDVANNGREVPLYAE
Sbjct: 241 KENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSNWTYDLFKDVANNGREVPLYAE 300
Query: 301 PIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGSGSLLAHL 360
PIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGSGSLLAHL
Sbjct: 301 PIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGSGSLLAHL 360
Query: 361 KKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLPQKWI 420
KKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLPQKWI
Sbjct: 361 KKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLPQKWI 420
Query: 421 FNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILAMGLLTKYEPDLLTQYTD 480
FNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILAMGLLTKYEPDLLTQYTD
Sbjct: 421 FNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILAMGLLTKYEPDLLTQYTD 480
Query: 481 ALVPENSRVTLISRSLETDSAEKWYGTAYKVVDYPADLIKNMKSPGLNPALTLPRPNEFV 540
ALVPENSRVTLISRSLETDSAEKWYGTAYKVVDYPADLIKNMKSPGLNPALTLPRPNEFV
Sbjct: 481 ALVPENSRVTLISRSLETDSAEKWYGTAYKVVDYPADLIKNMKSPGLNPALTLPRPNEFV 540
Query: 541 STNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLPHTHASIINS 600
STNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLPHTHASIINS
Sbjct: 541 STNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLPHTHASIINS 600
Query: 601 MLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLIILLTRFLQGVN 660
MLSTLYTQLANDALKD+QYDAACADLRISFNKTNQGLAITASGFNEKLIILLTRFLQGVN
Sbjct: 601 MLSTLYTQLANDALKDLQYDAACADLRISFNKTNQGLAITASGFNEKLIILLTRFLQGVN 660
Query: 661 SFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKLQVFEKLTFE 720
SFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKLQVFEKLTFE
Sbjct: 661 SFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKLQVFEKLTFE 720
Query: 721 QLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIHNLQVSNNRLRSYLLPK 780
QLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIHNLQVSNNRLRSYLLPK
Sbjct: 721 QLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIHNLQVSNNRLRSYLLPK 780
Query: 781 GKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFAQLIHEPCFDTLRTKEQLGY 840
GKTFRYETALKDS+NVNSCIQHVTQLDVYSEDLSALSGLFAQLIHEPCFDTLRTKEQLGY
Sbjct: 781 GKTFRYETALKDSRNVNSCIQHVTQLDVYSEDLSALSGLFAQLIHEPCFDTLRTKEQLGY 840
Query: 841 VVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVLRDMPEEDFEKHKEALCN 900
VVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVLRDMPEEDFEKHKEALCN
Sbjct: 841 VVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVLRDMPEEDFEKHKEALCN 900
Query: 901 SLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMIDFYENYIMSENASK 960
SLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMIDFYENYIMSENASK
Sbjct: 901 SLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMIDFYENYIMSENASK 960
Query: 961 LILHLKSQVENKELNENELDTAKYPTGQLIEDVGAFKSTLFVAPVRQPMKDFEISAPPKL 1020
LILHLKSQVENKELNENELDTAKYPTGQLIEDVGAFKSTLFVAPVRQPMKDFEISAPPKL
Sbjct: 961 LILHLKSQVENKELNENELDTAKYPTGQLIEDVGAFKSTLFVAPVRQPMKDFEISAPPKL 1020
Query: 1021 NNSSESE 1027
NNSSES+
Sbjct: 1021 NNSSESD 1027
>ref|NP_013493.2| Metalloprotease involved, with homolog Axl1p, in N-terminal
processing of pro-a-factor to the mature form; member of
the insulin-degrading enzyme family; Ste23p
[Saccharomyces cerevisiae]
sp|Q06010|STE23_YEAST A-factor-processing enzyme
gb|AAB82351.2| Ste23p [Saccharomyces cerevisiae]
Length = 1027
Score = 1176 bits (3043), Expect = 0.0, Method: Composition-based stats.
Identities = 1027/1027 (100%), Positives = 1027/1027 (100%)
Query: 1 MGVSLLASSSAFVTKPLLTQLVHLSPISLNFTVRRFKPFTCLSRYYTTNPYNMTSNFKTF 60
MGVSLLASSSAFVTKPLLTQLVHLSPISLNFTVRRFKPFTCLSRYYTTNPYNMTSNFKTF
Sbjct: 1 MGVSLLASSSAFVTKPLLTQLVHLSPISLNFTVRRFKPFTCLSRYYTTNPYNMTSNFKTF 60
Query: 61 NLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNLPGLAHFC 120
NLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNLPGLAHFC
Sbjct: 61 NLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNLPGLAHFC 120
Query: 121 EHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGALDRFSGFFS 180
EHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGALDRFSGFFS
Sbjct: 121 EHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGALDRFSGFFS 180
Query: 181 CPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGTLP 240
CPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGTLP
Sbjct: 181 CPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGTLP 240
Query: 241 KENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGREVPLYAE 300
KENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGREVPLYAE
Sbjct: 241 KENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGREVPLYAE 300
Query: 301 PIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGSGSLLAHL 360
PIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGSGSLLAHL
Sbjct: 301 PIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGSGSLLAHL 360
Query: 361 KKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLPQKWI 420
KKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLPQKWI
Sbjct: 361 KKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLPQKWI 420
Query: 421 FNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILAMGLLTKYEPDLLTQYTD 480
FNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILAMGLLTKYEPDLLTQYTD
Sbjct: 421 FNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILAMGLLTKYEPDLLTQYTD 480
Query: 481 ALVPENSRVTLISRSLETDSAEKWYGTAYKVVDYPADLIKNMKSPGLNPALTLPRPNEFV 540
ALVPENSRVTLISRSLETDSAEKWYGTAYKVVDYPADLIKNMKSPGLNPALTLPRPNEFV
Sbjct: 481 ALVPENSRVTLISRSLETDSAEKWYGTAYKVVDYPADLIKNMKSPGLNPALTLPRPNEFV 540
Query: 541 STNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLPHTHASIINS 600
STNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLPHTHASIINS
Sbjct: 541 STNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLPHTHASIINS 600
Query: 601 MLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLIILLTRFLQGVN 660
MLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLIILLTRFLQGVN
Sbjct: 601 MLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLIILLTRFLQGVN 660
Query: 661 SFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKLQVFEKLTFE 720
SFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKLQVFEKLTFE
Sbjct: 661 SFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKLQVFEKLTFE 720
Query: 721 QLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIHNLQVSNNRLRSYLLPK 780
QLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIHNLQVSNNRLRSYLLPK
Sbjct: 721 QLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIHNLQVSNNRLRSYLLPK 780
Query: 781 GKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFAQLIHEPCFDTLRTKEQLGY 840
GKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFAQLIHEPCFDTLRTKEQLGY
Sbjct: 781 GKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFAQLIHEPCFDTLRTKEQLGY 840
Query: 841 VVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVLRDMPEEDFEKHKEALCN 900
VVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVLRDMPEEDFEKHKEALCN
Sbjct: 841 VVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVLRDMPEEDFEKHKEALCN 900
Query: 901 SLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMIDFYENYIMSENASK 960
SLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMIDFYENYIMSENASK
Sbjct: 901 SLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMIDFYENYIMSENASK 960
Query: 961 LILHLKSQVENKELNENELDTAKYPTGQLIEDVGAFKSTLFVAPVRQPMKDFEISAPPKL 1020
LILHLKSQVENKELNENELDTAKYPTGQLIEDVGAFKSTLFVAPVRQPMKDFEISAPPKL
Sbjct: 961 LILHLKSQVENKELNENELDTAKYPTGQLIEDVGAFKSTLFVAPVRQPMKDFEISAPPKL 1020
Query: 1021 NNSSESE 1027
NNSSESE
Sbjct: 1021 NNSSESE 1027
>ref|XP_001506502.1| PREDICTED: similar to insulin-degrading enzyme [Ornithorhynchus
anatinus]
Length = 1301
Score = 1156 bits (2992), Expect = 0.0, Method: Composition-based stats.
Identities = 377/1011 (37%), Positives = 585/1011 (57%), Gaps = 20/1011 (1%)
Query: 18 LTQLVHLSPISLNFTVRRFKPFTCLSRYYTTNPYNMTSNFKTFNLDFLKPDLDERSYRFI 77
LT + ++ SL+ T + S + S K + +K D+R YR +
Sbjct: 290 LTAVGAVAFRSLSQTRPVANARSSFSFQRYSYGKMDHSAVKRIVNNIIKSPEDKREYRGL 349
Query: 78 ELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNLPGLAHFCEHLLFMGSEKFPDENEY 137
EL N +KA+LI DP DK++A+LDV+IG+ DP N+ GL+HFCEH+LF+G++K+P ENEY
Sbjct: 350 ELANGIKAILISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKKYPKENEY 409
Query: 138 SSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGALDRFSGFFSCPLFNKDSTDKEINAVN 197
S +LS+H GSSNA+T+ ++TNY+F+V+H+HL GALDRF+ FF CPLF++ D+E+NAV+
Sbjct: 410 SQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKDREVNAVD 469
Query: 198 SENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGTLPKENGLNVRDELLKFHKN 257
SE++KN+ ND WR++QL+K+ N HP+ KF TGN TL T P + G++VR ELLKFH
Sbjct: 470 SEHEKNVMNDAWRLFQLEKATGNPNHPFSKFGTGNKYTLETRPTKEGIDVRQELLKFHST 529
Query: 258 FYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGREVPLYAEPIMQPEHLQKIIQVRPV 317
+YS+NLM +C+LGRE LD L+ LF +V N +P + E Q HL++I +V P+
Sbjct: 530 YYSSNLMAICVLGRESLDELTSLVVKLFSEVENKNVPLPEFPEHPFQEHHLRQIYKVVPI 589
Query: 318 KDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGSGSLLAHLKKLGWANELSAGGHTVS 377
KD++ L ++F +PD++++++S P L HLIGHEG GSLL+ LK GW N L G +
Sbjct: 590 KDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKAKGWVNTLVGGQKEGA 649
Query: 378 KGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLPQKWIFNELQDISNATFKFKQA 437
+G FF +++DLT+ GL H D+I+ +FQYI+ L+ PQ+W+F E +D++ F+FK
Sbjct: 650 RGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRTEGPQEWVFQECKDLNAVAFRFKDK 709
Query: 438 GSPSSTVSSLAKCLEKDYIPVSRILAMGLLTKYEPDLLTQYTDALVPENSRVTLISRSLE 497
P S L + Y + A LL ++ PDL+ D L PEN RV ++S+S E
Sbjct: 710 ERPRGYTSKLGG-MLHYYPLEEVLAAEYLLEEFRPDLIEMVLDKLRPENVRVAIVSKSFE 768
Query: 498 --TDSAEKWYGTAYKVVDYPADLIKNMKSPGLNPALTLPRPNEFVSTNFKVDKIDGIKPL 555
TD E+WYGT YK ++IK ++ LN LP NEF+ +NF++ +++ P
Sbjct: 769 GKTDQTEEWYGTQYKQEAISDEVIKKWQNADLNGKFKLPMKNEFIPSNFEILQLEKEAP- 827
Query: 556 DEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLPHTHASIINSMLSTLYTQLANDALK 615
P L+ +SKLW+K+DD+F+ P+ + F P + ++ ++ LY +L D+L
Sbjct: 828 SYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELLKDSLN 887
Query: 616 DVQYDAACADLRISFNKTNQGLAITASGFNEKLIILLTRFLQGVNSFEPKKDRFEILKDK 675
+ Y A A L T G+ ++ G+N+K ILL + ++ + +FE + RFEI+K+
Sbjct: 888 EYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIVEKMATFEIDEKRFEIIKEA 947
Query: 676 TIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKLQVFEKLTFEQLINFIPTIYEGVYF 735
+R L N E P+ Y ++ E +W+ E + + +T +L FIP + ++
Sbjct: 948 YMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHI 1007
Query: 736 ETLIHGNIKHEEALEVDSLIKSLIPN---NIHNLQVSNNRLRSYLLPKGKTFRYETALKD 792
E L+HGNI + AL V +++ + L R R LP F Y+ ++
Sbjct: 1008 EALLHGNITKQAALGVMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQ--RN 1065
Query: 793 SQNVNSCIQHVTQLDVYSEDLSALSGLFAQLIHEPCFDTLRTKEQLGYVVFSSSLNNHGT 852
+ N I+ Q D+ S + LF Q+I EPCF+TLRTKEQLGY+VFS +G
Sbjct: 1066 EVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRANGI 1125
Query: 853 ANIRILIQSEHTTPYLEWRINNFYETFGQVLRDMPEEDFEKHKEALCNSLLQKFKNMAEE 912
+R +IQSE YLE R+ F T + + DM EE F+KH +AL L K K ++ E
Sbjct: 1126 QGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKLSAE 1185
Query: 913 SARYTAAIYLGDYNFTHRQKKAKLVANITKQQMIDFYENYIM--SENASKLILHLKSQ-- 968
A+Y I YNF + + +TK+ +I FY+ + + K+ +H+ ++
Sbjct: 1186 CAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIRFYKEMLAVEAPRRHKVSVHVLAREM 1245
Query: 969 ----VENKELNENELDTA---KYPTGQLIEDVGAFKSTLFVAPVRQPMKDF 1012
V + +N+++ A P ++IE++ AFK +L + P+ +P +
Sbjct: 1246 DSCPVVGEFPCQNDVNLAAAPALPQPEVIENMTAFKRSLPLFPLVKPHINL 1296
>ref|XP_001501085.1| PREDICTED: similar to insulin-degrading enzyme [Equus caballus]
Length = 1212
Score = 1144 bits (2961), Expect = 0.0, Method: Composition-based stats.
Identities = 369/981 (37%), Positives = 575/981 (58%), Gaps = 20/981 (2%)
Query: 48 TNPYNMTSNFKTFNLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAF 107
T K +K D+R YR ++L N +K LLI DP DK++A+LDV+IG+
Sbjct: 231 TYSKMNNPAIKRLGNHIIKSPEDKREYRGLQLANGIKVLLISDPTTDKSSAALDVHIGSL 290
Query: 108 EDPKNLPGLAHFCEHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQH 167
DP N+ GL+HFCEH+LF+G++K+P ENEYS +LS+H GSSNA+T+ ++TNY+F+V+H+H
Sbjct: 291 SDPPNIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEH 350
Query: 168 LFGALDRFSGFFSCPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHK 227
L GALDRF+ FF CPLF++ D+E+NAV+SE++KN+ ND WR++QL+K+ N KHP+ K
Sbjct: 351 LEGALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSK 410
Query: 228 FSTGNIETLGTLPKENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKD 287
F TGN TL T P + G++VR ELLKFH +YS+NLM +C+LGRE LD L+D LF +
Sbjct: 411 FGTGNKYTLETRPNQEGIDVRQELLKFHSTYYSSNLMAICVLGRESLDDLTDLVVKLFSE 470
Query: 288 VANNGREVPLYAEPIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHL 347
V N +P + E Q EHL+++ ++ P+KD++ L ++F +PD++++++S P L HL
Sbjct: 471 VENKNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHL 530
Query: 348 IGHEGSGSLLAHLKKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQY 407
IGHEG GSLL+ LK GW N L G ++G FF +++DLT+ GL H D+I+ +FQY
Sbjct: 531 IGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQY 590
Query: 408 IEMLKNSLPQKWIFNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILAMGLL 467
I+ L+ PQ+W+F E +D++ F+FK P S +A L Y + A LL
Sbjct: 591 IQKLRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHY-YPLEEVLTAEYLL 649
Query: 468 TKYEPDLLTQYTDALVPENSRVTLISRSLE--TDSAEKWYGTAYKVVDYPADLIKNMKSP 525
++ PDL+ D L PEN RV ++S+S E TD E+WYGT Y+ P ++IK ++
Sbjct: 650 EEFRPDLIEMVLDKLRPENVRVAVVSKSFEGKTDCTEEWYGTQYRQEAIPDEVIKKWQNA 709
Query: 526 GLNPALTLPRPNEFVSTNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIY 585
LN LP NEF+ TNF++ ++ + P L+ +SKLW+K+DD+F+ P+ +
Sbjct: 710 DLNGKFKLPTKNEFIPTNFEILSLE-KEATPYPSLIKDTAMSKLWFKQDDKFFLPKACLN 768
Query: 586 LSFKLPHTHASIINSMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFN 645
F P + ++ ++ LY +L D+L + Y A A L T G+ ++ G+N
Sbjct: 769 FEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYN 828
Query: 646 EKLIILLTRFLQGVNSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSW 705
+K ILL + ++ + +FE + RFEI+K+ +R L N E P+ Y ++ E +W
Sbjct: 829 DKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAW 888
Query: 706 STAEKLQVFEKLTFEQLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPN---N 762
+ E + + +T +L FIP + ++ E L+HGNI + AL + +++ +
Sbjct: 889 TKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHT 948
Query: 763 IHNLQVSNNRLRSYLLPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFAQ 822
L R R LP F Y+ ++ + N I+ Q D+ S + LF Q
Sbjct: 949 KPLLPSQLVRYREVQLPDRGWFVYQQ--RNEVHNNCGIEIYYQTDMQSTSENMFLELFCQ 1006
Query: 823 LIHEPCFDTLRTKEQLGYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQV 882
+I EPCF+TLRTKEQLGY+VFS +G +R +IQSE YLE R+ F T +
Sbjct: 1007 IISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKS 1066
Query: 883 LRDMPEEDFEKHKEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITK 942
+ DM EE F+KH +AL L K K ++ E A+Y I YNF + + +TK
Sbjct: 1067 IEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTK 1126
Query: 943 QQMIDFYEN--YIMSENASKLILHLKSQ------VENKELNENELDTAK---YPTGQLIE 991
+ +I FY+ + + K+ +H+ ++ V + +N+++ ++ P ++I+
Sbjct: 1127 EDIIKFYKEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPGLPQPEVIQ 1186
Query: 992 DVGAFKSTLFVAPVRQPMKDF 1012
++ FK L + P+ +P +F
Sbjct: 1187 NMTEFKRGLPLFPLVKPHINF 1207
>ref|XP_001090249.1| PREDICTED: insulysin isoform 3 [Macaca mulatta]
Length = 1019
Score = 1116 bits (2887), Expect = 0.0, Method: Composition-based stats.
Identities = 369/981 (37%), Positives = 574/981 (58%), Gaps = 20/981 (2%)
Query: 48 TNPYNMTSNFKTFNLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAF 107
T K K D+R YR +EL N +K LLI DP DK++A+LDV+IG+
Sbjct: 38 TYSKMNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSL 97
Query: 108 EDPKNLPGLAHFCEHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQH 167
DP N+ GL+HFCEH+LF+G++K+P ENEYS +LS+H GSSNA+T+ ++TNY+F+V+H+H
Sbjct: 98 SDPPNIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEH 157
Query: 168 LFGALDRFSGFFSCPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHK 227
L GALDRF+ FF CPLF++ D+E+NAV+SE++KN+ ND WR++QL+K+ N KHP+ K
Sbjct: 158 LEGALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSK 217
Query: 228 FSTGNIETLGTLPKENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKD 287
F TGN TL T P + G++VR ELLKFH +YS+NLM +C+LGRE LD L++ LF +
Sbjct: 218 FGTGNKYTLETRPNQEGIDVRQELLKFHSTYYSSNLMAVCVLGRESLDDLTNLVVKLFSE 277
Query: 288 VANNGREVPLYAEPIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHL 347
V N +P + E Q EHL+++ ++ P+KD++ L ++F +PD++++++S P L HL
Sbjct: 278 VENKSVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHL 337
Query: 348 IGHEGSGSLLAHLKKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQY 407
IGHEG GSLL+ LK GW N L G ++G FF +++DLT+ GL H D+I+ +FQY
Sbjct: 338 IGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQY 397
Query: 408 IEMLKNSLPQKWIFNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILAMGLL 467
I+ L+ PQ+W+F E +D++ F+FK P S +A L Y + A LL
Sbjct: 398 IQKLRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHY-YPLEEVLTAEYLL 456
Query: 468 TKYEPDLLTQYTDALVPENSRVTLISRSLE--TDSAEKWYGTAYKVVDYPADLIKNMKSP 525
++ PDL+ D L PEN RV ++S+S E TD E+WYGT YK P ++IK ++
Sbjct: 457 EEFRPDLIEMVLDKLRPENVRVAVVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNA 516
Query: 526 GLNPALTLPRPNEFVSTNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIY 585
LN LP NEF+ TNF++ ++ + P L+ +SKLW+K+DD+F+ P+ +
Sbjct: 517 DLNGKFKLPTKNEFIPTNFEILPLE-KEATPYPALIKDTAMSKLWFKQDDKFFLPKACLN 575
Query: 586 LSFKLPHTHASIINSMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFN 645
F P + ++ ++ LY +L D+L + Y A A L T G+ ++ G+N
Sbjct: 576 FEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYN 635
Query: 646 EKLIILLTRFLQGVNSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSW 705
+K ILL + ++ + +FE + RFEI+K+ +R L N E P+ Y ++ E +W
Sbjct: 636 DKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAW 695
Query: 706 STAEKLQVFEKLTFEQLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPN---N 762
+ E + + +T +L FIP + ++ E L+HGNI + AL + +++ +
Sbjct: 696 TKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHT 755
Query: 763 IHNLQVSNNRLRSYLLPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFAQ 822
L R R LP F Y+ ++ + N I+ Q D+ S + LF Q
Sbjct: 756 KPLLPSQLVRYREVQLPDRGWFVYQQ--RNEVHNNCGIEIYYQTDMQSTSENMFLELFCQ 813
Query: 823 LIHEPCFDTLRTKEQLGYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQV 882
+I EPCF+TLRTKEQLGY+VFS +G +R +IQSE YLE R+ F T +
Sbjct: 814 IISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKS 873
Query: 883 LRDMPEEDFEKHKEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITK 942
+ DM EE F+KH +AL L K K ++ E A+Y I Y+F + + +TK
Sbjct: 874 IEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYHFDRDNTEVAYLKTLTK 933
Query: 943 QQMIDFYEN--YIMSENASKLILHLKSQ------VENKELNENELDTAK---YPTGQLIE 991
+ +I FY+ + + K+ +H+ ++ V + +N+++ ++ P ++I+
Sbjct: 934 EDIIKFYKEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQ 993
Query: 992 DVGAFKSTLFVAPVRQPMKDF 1012
++ FK L + P+ +P +F
Sbjct: 994 NMTEFKRGLPLFPLVKPHINF 1014
>ref|NP_004960.2| insulysin [Homo sapiens]
emb|CAI13670.1| insulin-degrading enzyme [Homo sapiens]
gb|AAH96337.1| Insulin-degrading enzyme [Homo sapiens]
gb|AAH96339.1| Insulin-degrading enzyme [Homo sapiens]
gb|AAH96336.1| Insulin-degrading enzyme [Homo sapiens]
gb|EAW50090.1| insulin-degrading enzyme, isoform CRA_a [Homo sapiens]
gb|EAW50091.1| insulin-degrading enzyme, isoform CRA_a [Homo sapiens]
Length = 1019
Score = 1116 bits (2886), Expect = 0.0, Method: Composition-based stats.
Identities = 370/981 (37%), Positives = 574/981 (58%), Gaps = 20/981 (2%)
Query: 48 TNPYNMTSNFKTFNLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAF 107
T K K D+R YR +EL N +K LLI DP DK++A+LDV+IG+
Sbjct: 38 TYSKMNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSL 97
Query: 108 EDPKNLPGLAHFCEHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQH 167
DP N+ GL+HFCEH+LF+G++K+P ENEYS +LS+H GSSNA+T+ ++TNY+F+V+H+H
Sbjct: 98 SDPPNIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEH 157
Query: 168 LFGALDRFSGFFSCPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHK 227
L GALDRF+ FF CPLF++ D+E+NAV+SE++KN+ ND WR++QL+K+ N KHP+ K
Sbjct: 158 LEGALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSK 217
Query: 228 FSTGNIETLGTLPKENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKD 287
F TGN TL T P + G++VR ELLKFH +YS+NLM +C+LGRE LD L++ LF +
Sbjct: 218 FGTGNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSE 277
Query: 288 VANNGREVPLYAEPIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHL 347
V N +P + E Q EHL+++ ++ P+KD++ L ++F +PD++++++S P L HL
Sbjct: 278 VENKNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHL 337
Query: 348 IGHEGSGSLLAHLKKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQY 407
IGHEG GSLL+ LK GW N L G ++G FF +++DLT+ GL H D+I+ +FQY
Sbjct: 338 IGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQY 397
Query: 408 IEMLKNSLPQKWIFNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILAMGLL 467
I+ L+ PQ+W+F E +D++ F+FK P S +A L Y + A LL
Sbjct: 398 IQKLRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHY-YPLEEVLTAEYLL 456
Query: 468 TKYEPDLLTQYTDALVPENSRVTLISRSLE--TDSAEKWYGTAYKVVDYPADLIKNMKSP 525
++ PDL+ D L PEN RV ++S+S E TD E+WYGT YK P ++IK ++
Sbjct: 457 EEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNA 516
Query: 526 GLNPALTLPRPNEFVSTNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIY 585
LN LP NEF+ TNF++ ++ + P L+ +SKLW+K+DD+F+ P+ +
Sbjct: 517 DLNGKFKLPTKNEFIPTNFEILPLE-KEATPYPALIKDTAMSKLWFKQDDKFFLPKACLN 575
Query: 586 LSFKLPHTHASIINSMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFN 645
F P + ++ ++ LY +L D+L + Y A A L T G+ ++ G+N
Sbjct: 576 FEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYN 635
Query: 646 EKLIILLTRFLQGVNSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSW 705
+K ILL + ++ + +FE + RFEI+K+ +R L N E P+ Y ++ E +W
Sbjct: 636 DKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAW 695
Query: 706 STAEKLQVFEKLTFEQLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPN---N 762
+ E + + +T +L FIP + ++ E L+HGNI + AL + +++ +
Sbjct: 696 TKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHT 755
Query: 763 IHNLQVSNNRLRSYLLPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFAQ 822
L R R LP F Y+ ++ + N I+ Q D+ S + LF Q
Sbjct: 756 KPLLPSQLVRYREVQLPDRGWFVYQQ--RNEVHNNCGIEIYYQTDMQSTSENMFLELFCQ 813
Query: 823 LIHEPCFDTLRTKEQLGYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQV 882
+I EPCF+TLRTKEQLGY+VFS +G +R +IQSE YLE R+ F T +
Sbjct: 814 IISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKS 873
Query: 883 LRDMPEEDFEKHKEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITK 942
+ DM EE F+KH +AL L K K ++ E A+Y I YNF + + +TK
Sbjct: 874 IEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTK 933
Query: 943 QQMIDFYEN--YIMSENASKLILHLKSQ------VENKELNENELDTAK---YPTGQLIE 991
+ +I FY+ + + K+ +H+ ++ V + +N+++ ++ P ++I+
Sbjct: 934 EDIIKFYKEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQ 993
Query: 992 DVGAFKSTLFVAPVRQPMKDF 1012
++ FK L + P+ +P +F
Sbjct: 994 NMTEFKRGLPLFPLVKPHINF 1014
>ref|XP_507922.2| PREDICTED: insulysin isoform 4 [Pan troglodytes]
Length = 1019
Score = 1115 bits (2885), Expect = 0.0, Method: Composition-based stats.
Identities = 370/981 (37%), Positives = 574/981 (58%), Gaps = 20/981 (2%)
Query: 48 TNPYNMTSNFKTFNLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAF 107
T K K D+R YR +EL N +K LLI DP DK++A+LDV+IG+
Sbjct: 38 TYSKMNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSL 97
Query: 108 EDPKNLPGLAHFCEHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQH 167
DP N+ GL+HFCEH+LF+G++K+P ENEYS +LS+H GSSNA+T+ ++TNY+F+V+H+H
Sbjct: 98 SDPPNIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEH 157
Query: 168 LFGALDRFSGFFSCPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHK 227
L GALDRF+ FF CPLF++ D+E+NAV+SE++KN+ ND WR++QL+K+ N KHP+ K
Sbjct: 158 LEGALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSK 217
Query: 228 FSTGNIETLGTLPKENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKD 287
F TGN TL T P + G++VR ELLKFH +YS+NLM +C+LGRE LD L++ LF +
Sbjct: 218 FGTGNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSE 277
Query: 288 VANNGREVPLYAEPIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHL 347
V N +P + E Q EHL+++ ++ P+KD++ L ++F +PD++++++S P L HL
Sbjct: 278 VENKNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHL 337
Query: 348 IGHEGSGSLLAHLKKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQY 407
IGHEG GSLL+ LK GW N L G ++G FF +++DLT+ GL H D+I+ +FQY
Sbjct: 338 IGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQY 397
Query: 408 IEMLKNSLPQKWIFNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILAMGLL 467
I+ L+ PQ+W+F E +D++ F+FK P S +A L Y + A LL
Sbjct: 398 IQKLRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHY-YPLEEVLTAEYLL 456
Query: 468 TKYEPDLLTQYTDALVPENSRVTLISRSLE--TDSAEKWYGTAYKVVDYPADLIKNMKSP 525
++ PDL+ D L PEN RV ++S+S E TD E+WYGT YK P ++IK ++
Sbjct: 457 EEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNA 516
Query: 526 GLNPALTLPRPNEFVSTNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIY 585
LN LP NEF+ TNF++ ++ + P L+ +SKLW+K+DD+F+ P+ +
Sbjct: 517 DLNGKFKLPTKNEFIPTNFEILPLE-KEATPYPALIKDTAMSKLWFKQDDKFFLPKACLN 575
Query: 586 LSFKLPHTHASIINSMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFN 645
F P + ++ ++ LY +L D+L + Y A A L T G+ ++ G+N
Sbjct: 576 FEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYN 635
Query: 646 EKLIILLTRFLQGVNSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSW 705
+K ILL + ++ + +FE + RFEI+K+ +R L N E P+ Y ++ E +W
Sbjct: 636 DKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAW 695
Query: 706 STAEKLQVFEKLTFEQLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPN---N 762
+ E + + +T +L FIP + ++ E L+HGNI + AL + +++ +
Sbjct: 696 TKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHT 755
Query: 763 IHNLQVSNNRLRSYLLPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFAQ 822
L R R LP F Y+ ++ + N I+ Q D+ S + LF Q
Sbjct: 756 KPLLPSQLVRYREVQLPDRGWFVYQQ--RNEVHNNCGIEIYYQTDMQSTSENMFLELFCQ 813
Query: 823 LIHEPCFDTLRTKEQLGYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQV 882
+I EPCF+TLRTKEQLGY+VFS +G +R +IQSE YLE R+ F T +
Sbjct: 814 IISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKS 873
Query: 883 LRDMPEEDFEKHKEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITK 942
+ DM EE F+KH +AL L K K ++ E A+Y I YNF + + +TK
Sbjct: 874 IEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTK 933
Query: 943 QQMIDFYEN--YIMSENASKLILHLKSQ------VENKELNENELDTAK---YPTGQLIE 991
+ +I FY+ + + K+ +H+ ++ V + +N+++ ++ P ++I+
Sbjct: 934 EDIIKFYKEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQ 993
Query: 992 DVGAFKSTLFVAPVRQPMKDF 1012
++ FK L + P+ +P +F
Sbjct: 994 NMTEFKRGLPLFPLVKPHINF 1014
>ref|NP_112419.2| insulin degrading enzyme [Mus musculus]
gb|AAH41675.1| Insulin degrading enzyme [Mus musculus]
Length = 1019
Score = 1111 bits (2874), Expect = 0.0, Method: Composition-based stats.
Identities = 370/981 (37%), Positives = 567/981 (57%), Gaps = 20/981 (2%)
Query: 48 TNPYNMTSNFKTFNLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAF 107
T + +K D+R YR +EL N +K LLI DP DK++A+LDV+IG+
Sbjct: 38 TYSTMSNPAIQRIEDQIVKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSL 97
Query: 108 EDPKNLPGLAHFCEHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQH 167
DP N+PGL+HFCEH+LF+G++K+P ENEYS +LS+H GSSNA+T+ ++TNY+F+V+H+H
Sbjct: 98 SDPPNIPGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEH 157
Query: 168 LFGALDRFSGFFSCPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHK 227
L GALDRF+ FF CPLF+ D+E+NAV+SE++KN+ ND WR++QL+K+ N KHP+ K
Sbjct: 158 LEGALDRFAQFFLCPLFDASCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSK 217
Query: 228 FSTGNIETLGTLPKENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKD 287
F TGN TL T P + G++VR+ELLKFH +YS+NLM +C+LGRE LD L++ LF +
Sbjct: 218 FGTGNKYTLETRPNQEGIDVREELLKFHSTYYSSNLMAICVLGRESLDDLTNLVVKLFSE 277
Query: 288 VANNGREVPLYAEPIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHL 347
V N +P + E Q EHL+++ ++ P+KD++ L ++F +PD++++++S P L HL
Sbjct: 278 VENKNVPLPEFPEHPFQEEHLRQLYKIVPIKDIRNLYVTFPIPDLQQYYKSNPGHYLGHL 337
Query: 348 IGHEGSGSLLAHLKKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQY 407
IGHEG GSLL+ LK GW N L G ++G FF +++DLT+ GL H D+I+ +FQY
Sbjct: 338 IGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQY 397
Query: 408 IEMLKNSLPQKWIFNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILAMGLL 467
I+ L+ PQ+W+F E +D++ F+FK P S +A L Y + A LL
Sbjct: 398 IQKLRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGKLHY-YPLNGVLTAEYLL 456
Query: 468 TKYEPDLLTQYTDALVPENSRVTLISRSLE--TDSAEKWYGTAYKVVDYPADLIKNMKSP 525
++ PDL+ D L PEN RV ++S+S E TD E+WYGT YK P D+I+ ++
Sbjct: 457 EEFRPDLIDMVLDKLRPENVRVAIVSKSFEGKTDRTEQWYGTQYKQEAIPEDIIQKWQNA 516
Query: 526 GLNPALTLPRPNEFVSTNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIY 585
LN LP NEF+ TNF++ ++ P L+ +SKLW+K+DD+F+ P+ +
Sbjct: 517 DLNGKFKLPTKNEFIPTNFEILSLEKDATP-YPALIKDTAMSKLWFKQDDKFFLPKACLN 575
Query: 586 LSFKLPHTHASIINSMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFN 645
F P + ++ ++ LY +L D+L + Y A A L T G+ ++ G+N
Sbjct: 576 FEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYN 635
Query: 646 EKLIILLTRFLQGVNSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSW 705
+K ILL + + + +FE K RFEI+K+ +R L N E P+ Y ++ E +W
Sbjct: 636 DKQPILLKKITEKMATFEIDKKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAW 695
Query: 706 STAEKLQVFEKLTFEQLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPN---N 762
+ E + + +T +L FIP + ++ E L+HGNI + AL V +++ +
Sbjct: 696 TKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGVMQMVEDTLIEHAHT 755
Query: 763 IHNLQVSNNRLRSYLLPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFAQ 822
L R R LP F Y+ ++ + N I+ Q D+ S + LF Q
Sbjct: 756 KPLLPSQLVRYREVQLPDRGWFVYQQ--RNEVHNNCGIEIYYQTDMQSTSENMFLELFCQ 813
Query: 823 LIHEPCFDTLRTKEQLGYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQV 882
+I EPCF+TLRTKEQLGY+VFS +G +R +IQSE YLE R+ F T +
Sbjct: 814 IISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKA 873
Query: 883 LRDMPEEDFEKHKEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITK 942
+ DM EE F+KH +AL L K K ++ E A+Y I YN+ + + +TK
Sbjct: 874 IEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNYDRDNIEVAYLKTLTK 933
Query: 943 QQMIDFYEN--YIMSENASKLILHLKSQ---------VENKELNENELDTAKYPTGQLIE 991
+I FY+ + + K+ +H+ ++ + + N + P ++I
Sbjct: 934 DDIIRFYQEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPSQNDINLSEAPPLPQPEVIH 993
Query: 992 DVGAFKSTLFVAPVRQPMKDF 1012
++ FK L + P+ +P +F
Sbjct: 994 NMTEFKRGLPLFPLVKPHINF 1014
>ref|NP_001069317.1| insulin-degrading enzyme [Bos taurus]
sp|Q24K02|IDE_BOVIN Insulin-degrading enzyme (Insulysin) (Insulinase) (Insulin protease)
gb|AAI14106.1| Similar to Insulin-degrading enzyme (Insulysin) (Insulinase) (Insulin
protease) [Bos taurus]
Length = 1019
Score = 1109 bits (2870), Expect = 0.0, Method: Composition-based stats.
Identities = 369/981 (37%), Positives = 575/981 (58%), Gaps = 20/981 (2%)
Query: 48 TNPYNMTSNFKTFNLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAF 107
T K +K D+R YR +EL N +K LL+ DP DK++A+LDV+IG+
Sbjct: 38 TYSKMNNPAIKRIGHHIIKSHEDKREYRGLELANGIKVLLVSDPTTDKSSAALDVHIGSL 97
Query: 108 EDPKNLPGLAHFCEHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQH 167
DP N+ GL+HFCEH+LF+G++K+P ENEYS +LS+H GSSNA+T+ ++TNY+F+V+H+H
Sbjct: 98 SDPPNIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEH 157
Query: 168 LFGALDRFSGFFSCPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHK 227
L GALDRF+ FF CPLF++ D+E+NAV+SE++KN+ ND WR++QL+K+ N KHP+ K
Sbjct: 158 LEGALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSK 217
Query: 228 FSTGNIETLGTLPKENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKD 287
F TGN TL T P + G++VR ELLKFH +YS+NLM +C+LGRE LD L++ LF +
Sbjct: 218 FGTGNKYTLETRPNQEGIDVRQELLKFHSTYYSSNLMAICVLGRESLDDLTNLVVKLFSE 277
Query: 288 VANNGREVPLYAEPIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHL 347
V N +P + E Q EHL+++ ++ P+KD++ L ++F +PD++++++S P L HL
Sbjct: 278 VENKNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHL 337
Query: 348 IGHEGSGSLLAHLKKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQY 407
IGHEG GSLL+ LK GW N L G ++G FF +++DLT+ GL H D+I+ +FQY
Sbjct: 338 IGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQY 397
Query: 408 IEMLKNSLPQKWIFNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILAMGLL 467
I+ L+ PQ+W+F E +D++ F+FK P S +A L Y + A LL
Sbjct: 398 IQKLRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHY-YPLEEVLTAEYLL 456
Query: 468 TKYEPDLLTQYTDALVPENSRVTLISRSLE--TDSAEKWYGTAYKVVDYPADLIKNMKSP 525
++ PDL+ D L PEN RV ++S+S E TD E+WYGT YK P ++IK ++
Sbjct: 457 EEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNA 516
Query: 526 GLNPALTLPRPNEFVSTNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIY 585
LN LP NEF+ TNF++ ++ + P L+ +SKLW+K+DD+F+ P+ +
Sbjct: 517 DLNGKFKLPMKNEFIPTNFEILSLE-KEATPYPSLIKDTAMSKLWFKQDDKFFLPKACLN 575
Query: 586 LSFKLPHTHASIINSMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFN 645
F P + ++ ++ LY +L D+L + Y A A L T G+ ++ G+N
Sbjct: 576 FEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYN 635
Query: 646 EKLIILLTRFLQGVNSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSW 705
+K ILL + ++ + +FE + RFEI+K+ +R L N E P+ Y ++ E +W
Sbjct: 636 DKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAW 695
Query: 706 STAEKLQVFEKLTFEQLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPN---N 762
+ E + + +T +L FIP + ++ E L+HGNI + AL + +++ +
Sbjct: 696 TKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHT 755
Query: 763 IHNLQVSNNRLRSYLLPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFAQ 822
L R R LP F Y+ ++ + N I+ Q D+ S + LF Q
Sbjct: 756 KPLLPSQLVRYREVQLPDRGWFVYQQ--RNEVHNNCGIEIYYQTDMQSTSENMFLELFCQ 813
Query: 823 LIHEPCFDTLRTKEQLGYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQV 882
+I EPCF+TLRTKEQLGY+VFS +G +R +IQSE YLE R+ F T +
Sbjct: 814 IISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKS 873
Query: 883 LRDMPEEDFEKHKEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITK 942
+ DM EE F+KH +AL L K K ++ E A+Y I YNF + + +TK
Sbjct: 874 IEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNIEVAYLKTLTK 933
Query: 943 QQMIDFYEN--YIMSENASKLILHLKSQ------VENKELNENELDTAK---YPTGQLIE 991
+ +I FY+ + + K+ +H+ ++ V + +N+++ ++ P ++I+
Sbjct: 934 EDIIKFYKEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQ 993
Query: 992 DVGAFKSTLFVAPVRQPMKDF 1012
++ FK L + P+ +P +F
Sbjct: 994 NMTEFKRGLPLFPLVKPHINF 1014
>ref|XP_001090137.1| PREDICTED: insulysin isoform 2 [Macaca mulatta]
Length = 978
Score = 1109 bits (2868), Expect = 0.0, Method: Composition-based stats.
Identities = 368/977 (37%), Positives = 573/977 (58%), Gaps = 20/977 (2%)
Query: 52 NMTSNFKTFNLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPK 111
K K D+R YR +EL N +K LLI DP DK++A+LDV+IG+ DP
Sbjct: 1 MNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPP 60
Query: 112 NLPGLAHFCEHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGA 171
N+ GL+HFCEH+LF+G++K+P ENEYS +LS+H GSSNA+T+ ++TNY+F+V+H+HL GA
Sbjct: 61 NIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGA 120
Query: 172 LDRFSGFFSCPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTG 231
LDRF+ FF CPLF++ D+E+NAV+SE++KN+ ND WR++QL+K+ N KHP+ KF TG
Sbjct: 121 LDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTG 180
Query: 232 NIETLGTLPKENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANN 291
N TL T P + G++VR ELLKFH +YS+NLM +C+LGRE LD L++ LF +V N
Sbjct: 181 NKYTLETRPNQEGIDVRQELLKFHSTYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENK 240
Query: 292 GREVPLYAEPIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHE 351
+P + E Q EHL+++ ++ P+KD++ L ++F +PD++++++S P L HLIGHE
Sbjct: 241 SVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHE 300
Query: 352 GSGSLLAHLKKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEML 411
G GSLL+ LK GW N L G ++G FF +++DLT+ GL H D+I+ +FQYI+ L
Sbjct: 301 GPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKL 360
Query: 412 KNSLPQKWIFNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILAMGLLTKYE 471
+ PQ+W+F E +D++ F+FK P S +A L Y + A LL ++
Sbjct: 361 RAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHY-YPLEEVLTAEYLLEEFR 419
Query: 472 PDLLTQYTDALVPENSRVTLISRSLE--TDSAEKWYGTAYKVVDYPADLIKNMKSPGLNP 529
PDL+ D L PEN RV ++S+S E TD E+WYGT YK P ++IK ++ LN
Sbjct: 420 PDLIEMVLDKLRPENVRVAVVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNG 479
Query: 530 ALTLPRPNEFVSTNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFK 589
LP NEF+ TNF++ ++ + P L+ +SKLW+K+DD+F+ P+ + F
Sbjct: 480 KFKLPTKNEFIPTNFEILPLE-KEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFF 538
Query: 590 LPHTHASIINSMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLI 649
P + ++ ++ LY +L D+L + Y A A L T G+ ++ G+N+K
Sbjct: 539 SPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQP 598
Query: 650 ILLTRFLQGVNSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAE 709
ILL + ++ + +FE + RFEI+K+ +R L N E P+ Y ++ E +W+ E
Sbjct: 599 ILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDE 658
Query: 710 KLQVFEKLTFEQLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPN---NIHNL 766
+ + +T +L FIP + ++ E L+HGNI + AL + +++ + L
Sbjct: 659 LKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLL 718
Query: 767 QVSNNRLRSYLLPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFAQLIHE 826
R R LP F Y+ ++ + N I+ Q D+ S + LF Q+I E
Sbjct: 719 PSQLVRYREVQLPDRGWFVYQQ--RNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISE 776
Query: 827 PCFDTLRTKEQLGYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVLRDM 886
PCF+TLRTKEQLGY+VFS +G +R +IQSE YLE R+ F T + + DM
Sbjct: 777 PCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDM 836
Query: 887 PEEDFEKHKEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMI 946
EE F+KH +AL L K K ++ E A+Y I Y+F + + +TK+ +I
Sbjct: 837 TEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYHFDRDNTEVAYLKTLTKEDII 896
Query: 947 DFYEN--YIMSENASKLILHLKSQ------VENKELNENELDTAK---YPTGQLIEDVGA 995
FY+ + + K+ +H+ ++ V + +N+++ ++ P ++I+++
Sbjct: 897 KFYKEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTE 956
Query: 996 FKSTLFVAPVRQPMKDF 1012
FK L + P+ +P +F
Sbjct: 957 FKRGLPLFPLVKPHINF 973
>ref|XP_001146520.1| PREDICTED: insulysin isoform 2 [Pan troglodytes]
gb|EAW50093.1| insulin-degrading enzyme, isoform CRA_c [Homo sapiens]
Length = 978
Score = 1108 bits (2867), Expect = 0.0, Method: Composition-based stats.
Identities = 369/977 (37%), Positives = 573/977 (58%), Gaps = 20/977 (2%)
Query: 52 NMTSNFKTFNLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPK 111
K K D+R YR +EL N +K LLI DP DK++A+LDV+IG+ DP
Sbjct: 1 MNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPP 60
Query: 112 NLPGLAHFCEHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGA 171
N+ GL+HFCEH+LF+G++K+P ENEYS +LS+H GSSNA+T+ ++TNY+F+V+H+HL GA
Sbjct: 61 NIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGA 120
Query: 172 LDRFSGFFSCPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTG 231
LDRF+ FF CPLF++ D+E+NAV+SE++KN+ ND WR++QL+K+ N KHP+ KF TG
Sbjct: 121 LDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTG 180
Query: 232 NIETLGTLPKENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANN 291
N TL T P + G++VR ELLKFH +YS+NLM +C+LGRE LD L++ LF +V N
Sbjct: 181 NKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENK 240
Query: 292 GREVPLYAEPIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHE 351
+P + E Q EHL+++ ++ P+KD++ L ++F +PD++++++S P L HLIGHE
Sbjct: 241 NVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHE 300
Query: 352 GSGSLLAHLKKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEML 411
G GSLL+ LK GW N L G ++G FF +++DLT+ GL H D+I+ +FQYI+ L
Sbjct: 301 GPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKL 360
Query: 412 KNSLPQKWIFNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILAMGLLTKYE 471
+ PQ+W+F E +D++ F+FK P S +A L Y + A LL ++
Sbjct: 361 RAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHY-YPLEEVLTAEYLLEEFR 419
Query: 472 PDLLTQYTDALVPENSRVTLISRSLE--TDSAEKWYGTAYKVVDYPADLIKNMKSPGLNP 529
PDL+ D L PEN RV ++S+S E TD E+WYGT YK P ++IK ++ LN
Sbjct: 420 PDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNG 479
Query: 530 ALTLPRPNEFVSTNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFK 589
LP NEF+ TNF++ ++ + P L+ +SKLW+K+DD+F+ P+ + F
Sbjct: 480 KFKLPTKNEFIPTNFEILPLE-KEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFF 538
Query: 590 LPHTHASIINSMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLI 649
P + ++ ++ LY +L D+L + Y A A L T G+ ++ G+N+K
Sbjct: 539 SPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQP 598
Query: 650 ILLTRFLQGVNSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAE 709
ILL + ++ + +FE + RFEI+K+ +R L N E P+ Y ++ E +W+ E
Sbjct: 599 ILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDE 658
Query: 710 KLQVFEKLTFEQLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPN---NIHNL 766
+ + +T +L FIP + ++ E L+HGNI + AL + +++ + L
Sbjct: 659 LKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLL 718
Query: 767 QVSNNRLRSYLLPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFAQLIHE 826
R R LP F Y+ ++ + N I+ Q D+ S + LF Q+I E
Sbjct: 719 PSQLVRYREVQLPDRGWFVYQQ--RNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISE 776
Query: 827 PCFDTLRTKEQLGYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVLRDM 886
PCF+TLRTKEQLGY+VFS +G +R +IQSE YLE R+ F T + + DM
Sbjct: 777 PCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDM 836
Query: 887 PEEDFEKHKEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMI 946
EE F+KH +AL L K K ++ E A+Y I YNF + + +TK+ +I
Sbjct: 837 TEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDII 896
Query: 947 DFYEN--YIMSENASKLILHLKSQ------VENKELNENELDTAK---YPTGQLIEDVGA 995
FY+ + + K+ +H+ ++ V + +N+++ ++ P ++I+++
Sbjct: 897 KFYKEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTE 956
Query: 996 FKSTLFVAPVRQPMKDF 1012
FK L + P+ +P +F
Sbjct: 957 FKRGLPLFPLVKPHINF 973
>pdb|2G47|A Chain A, Crystal Structure Of Human Insulin-Degrading Enzyme In
Complex With Amyloid-Beta (1-40)
pdb|2G47|B Chain B, Crystal Structure Of Human Insulin-Degrading Enzyme In
Complex With Amyloid-Beta (1-40)
pdb|2G48|A Chain A, Crystal Structure Of Human Insulin-Degrading Enzyme In
Complex With Amylin
pdb|2G48|B Chain B, Crystal Structure Of Human Insulin-Degrading Enzyme In
Complex With Amylin
pdb|2G49|A Chain A, Crystal Structure Of Human Insulin-Degrading Enzyme In
Complex With Glucagon
pdb|2G49|B Chain B, Crystal Structure Of Human Insulin-Degrading Enzyme In
Complex With Glucagon
pdb|2G54|A Chain A, Crystal Structure Of Zn-Bound Human Insulin-Degrading Enzyme
In Complex With Insulin B Chain
pdb|2G54|B Chain B, Crystal Structure Of Zn-Bound Human Insulin-Degrading Enzyme
In Complex With Insulin B Chain
pdb|2G56|A Chain A, Crystal Structure Of Human Insulin-Degrading Enzyme In
Complex With Insulin B Chain
pdb|2G56|B Chain B, Crystal Structure Of Human Insulin-Degrading Enzyme In
Complex With Insulin B Chain
pdb|2JBU|A Chain A, Crystal Structure Of Human Insulin Degrading Enzyme
Complexed With Co-Purified Peptides.
pdb|2JBU|B Chain B, Crystal Structure Of Human Insulin Degrading Enzyme
Complexed With Co-Purified Peptides.
Length = 990
Score = 1108 bits (2866), Expect = 0.0, Method: Composition-based stats.
Identities = 368/978 (37%), Positives = 573/978 (58%), Gaps = 20/978 (2%)
Query: 51 YNMTSNFKTFNLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDP 110
K K D+R YR +EL N +K LLI DP DK++A+LDV+IG+ DP
Sbjct: 12 PMNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDP 71
Query: 111 KNLPGLAHFCEHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFG 170
N+ GL+HFC+H+LF+G++K+P ENEYS +LS+H GSSNA+T+ ++TNY+F+V+H+HL G
Sbjct: 72 PNIAGLSHFCQHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEG 131
Query: 171 ALDRFSGFFSCPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFST 230
ALDRF+ FF CPLF++ D+E+NAV+SE++KN+ ND WR++QL+K+ N KHP+ KF T
Sbjct: 132 ALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGT 191
Query: 231 GNIETLGTLPKENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVAN 290
GN TL T P + G++VR ELLKFH +YS+NLM +C+LGRE LD L++ LF +V N
Sbjct: 192 GNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVEN 251
Query: 291 NGREVPLYAEPIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGH 350
+P + E Q EHL+++ ++ P+KD++ L ++F +PD++++++S P L HLIGH
Sbjct: 252 KNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGH 311
Query: 351 EGSGSLLAHLKKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEM 410
EG GSLL+ LK GW N L G ++G FF +++DLT+ GL H D+I+ +FQYI+
Sbjct: 312 EGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQK 371
Query: 411 LKNSLPQKWIFNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILAMGLLTKY 470
L+ PQ+W+F E +D++ F+FK P S +A L Y + A LL ++
Sbjct: 372 LRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHY-YPLEEVLTAEYLLEEF 430
Query: 471 EPDLLTQYTDALVPENSRVTLISRSLE--TDSAEKWYGTAYKVVDYPADLIKNMKSPGLN 528
PDL+ D L PEN RV ++S+S E TD E+WYGT YK P ++IK ++ LN
Sbjct: 431 RPDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLN 490
Query: 529 PALTLPRPNEFVSTNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSF 588
LP NEF+ TNF++ ++ + P L+ +SKLW+K+DD+F+ P+ + F
Sbjct: 491 GKFKLPTKNEFIPTNFEILPLE-KEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEF 549
Query: 589 KLPHTHASIINSMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKL 648
P + ++ ++ LY +L D+L + Y A A L T G+ ++ G+N+K
Sbjct: 550 FSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQ 609
Query: 649 IILLTRFLQGVNSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTA 708
ILL + ++ + +FE + RFEI+K+ +R L N E P+ Y ++ E +W+
Sbjct: 610 PILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKD 669
Query: 709 EKLQVFEKLTFEQLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPN---NIHN 765
E + + +T +L FIP + ++ E L+HGNI + AL + +++ +
Sbjct: 670 ELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPL 729
Query: 766 LQVSNNRLRSYLLPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFAQLIH 825
L R R LP F Y+ ++ + N I+ Q D+ S + LF Q+I
Sbjct: 730 LPSQLVRYREVQLPDRGWFVYQQ--RNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIIS 787
Query: 826 EPCFDTLRTKEQLGYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVLRD 885
EPCF+TLRTKEQLGY+VFS +G +R +IQSE YLE R+ F T + + D
Sbjct: 788 EPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIED 847
Query: 886 MPEEDFEKHKEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQM 945
M EE F+KH +AL L K K ++ E A+Y I YNF + + +TK+ +
Sbjct: 848 MTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDI 907
Query: 946 IDFYEN--YIMSENASKLILHLKSQ------VENKELNENELDTAK---YPTGQLIEDVG 994
I FY+ + + K+ +H+ ++ V + +N+++ ++ P ++I+++
Sbjct: 908 IKFYKEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMT 967
Query: 995 AFKSTLFVAPVRQPMKDF 1012
FK L + P+ +P +F
Sbjct: 968 EFKRGLPLFPLVKPHINF 985
>pdb|2JG4|A Chain A, Substrate-Free Ide Structure In Its Closed Conformation
pdb|2JG4|B Chain B, Substrate-Free Ide Structure In Its Closed Conformation
Length = 990
Score = 1107 bits (2864), Expect = 0.0, Method: Composition-based stats.
Identities = 368/978 (37%), Positives = 573/978 (58%), Gaps = 20/978 (2%)
Query: 51 YNMTSNFKTFNLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDP 110
K K D+R YR +EL N +K LLI DP DK++A+LDV+IG+ DP
Sbjct: 12 PMNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDP 71
Query: 111 KNLPGLAHFCEHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFG 170
N+ GL+HFCEH+LF+G++K+P ENEYS +LS+H GSSNA+T+ ++TNY+F+V+H+HL G
Sbjct: 72 PNIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEG 131
Query: 171 ALDRFSGFFSCPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFST 230
ALDRF+ FF CPLF++ D+E+NAV+SE++KN+ ND WR++QL+K+ N KHP+ KF T
Sbjct: 132 ALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGT 191
Query: 231 GNIETLGTLPKENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVAN 290
GN TL T P + G++VR ELLKFH +YS+NLM +C+LGRE LD L++ LF +V N
Sbjct: 192 GNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVEN 251
Query: 291 NGREVPLYAEPIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGH 350
+P + E Q EHL+++ ++ P+KD++ L ++F +PD++++++S P L HLIGH
Sbjct: 252 KNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGH 311
Query: 351 EGSGSLLAHLKKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEM 410
EG GSLL+ LK GW N L G ++G FF +++DLT+ GL H D+I+ +FQYI+
Sbjct: 312 EGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQK 371
Query: 411 LKNSLPQKWIFNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILAMGLLTKY 470
L+ PQ+W+F E +D++ F+FK P S +A L Y + A LL ++
Sbjct: 372 LRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHY-YPLEEVLTAEYLLEEF 430
Query: 471 EPDLLTQYTDALVPENSRVTLISRSLE--TDSAEKWYGTAYKVVDYPADLIKNMKSPGLN 528
PDL+ D L PEN RV ++S+S E TD E+WYGT YK P ++IK ++ LN
Sbjct: 431 RPDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLN 490
Query: 529 PALTLPRPNEFVSTNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSF 588
LP NEF+ TNF++ ++ + P L+ +SKLW+K+DD+F+ P+ + F
Sbjct: 491 GKFKLPTKNEFIPTNFEILPLE-KEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEF 549
Query: 589 KLPHTHASIINSMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKL 648
P + ++ ++ LY +L D+L + Y A A L T G+ ++ G+N+K
Sbjct: 550 FSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQ 609
Query: 649 IILLTRFLQGVNSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTA 708
ILL + ++ + +FE + RFEI+K+ +R L N E P+ Y ++ E +W+
Sbjct: 610 PILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKD 669
Query: 709 EKLQVFEKLTFEQLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPN---NIHN 765
E + + +T +L FIP + ++ E L+HGNI + AL + +++ +
Sbjct: 670 ELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPL 729
Query: 766 LQVSNNRLRSYLLPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFAQLIH 825
L R R LP F Y+ ++ + N I+ Q D+ S + LF Q+I
Sbjct: 730 LPSQLVRYREVQLPDRGWFVYQQ--RNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIIS 787
Query: 826 EPCFDTLRTKEQLGYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVLRD 885
EPCF+TLRTKEQLG++VFS +G +R +IQSE YLE R+ F T + + D
Sbjct: 788 EPCFNTLRTKEQLGFIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIED 847
Query: 886 MPEEDFEKHKEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQM 945
M EE F+KH +AL L K K ++ E A+Y I YNF + + +TK+ +
Sbjct: 848 MTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDI 907
Query: 946 IDFYEN--YIMSENASKLILHLKSQ------VENKELNENELDTAK---YPTGQLIEDVG 994
I FY+ + + K+ +H+ ++ V + +N+++ ++ P ++I+++
Sbjct: 908 IKFYKEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMT 967
Query: 995 AFKSTLFVAPVRQPMKDF 1012
FK L + P+ +P +F
Sbjct: 968 EFKRGLPLFPLVKPHINF 985
>ref|NP_037291.1| insulin degrading enzyme [Rattus norvegicus]
sp|P35559|IDE_RAT Insulin-degrading enzyme (Insulysin) (Insulinase) (Insulin protease)
emb|CAA47689.1| insulin-degrading enzyme [Rattus norvegicus]
gb|EDM13196.1| insulin degrading enzyme [Rattus norvegicus]
Length = 1019
Score = 1106 bits (2861), Expect = 0.0, Method: Composition-based stats.
Identities = 368/980 (37%), Positives = 566/980 (57%), Gaps = 20/980 (2%)
Query: 49 NPYNMTSNFKTFNLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFE 108
+ +K D+R YR +EL N +K LLI DP DK++A+LDV+IG+
Sbjct: 39 YSTMNNPAIQRIEDHIVKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLS 98
Query: 109 DPKNLPGLAHFCEHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHL 168
DP N+PGL+HFCEH+LF+G++K+P ENEYS +LS+H GSSNA+T+ ++TNY+F+V+H+HL
Sbjct: 99 DPPNIPGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHL 158
Query: 169 FGALDRFSGFFSCPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKF 228
GALDRF+ FF CPLF+ D+E+NAV+SE++KN+ ND WR++QL+K+ N KHP+ KF
Sbjct: 159 EGALDRFAQFFLCPLFDASCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKF 218
Query: 229 STGNIETLGTLPKENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDV 288
TGN TL T P + G++VR+ELLKFH +YS+NLM +C+LGRE LD L++ LF +V
Sbjct: 219 GTGNKYTLETRPNQEGIDVREELLKFHSTYYSSNLMAICVLGRESLDDLTNLVVKLFSEV 278
Query: 289 ANNGREVPLYAEPIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLI 348
N +P + E Q EHL+++ ++ P+KD++ L ++F +PD++++++S P L HLI
Sbjct: 279 ENKNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQQYYKSNPGHYLGHLI 338
Query: 349 GHEGSGSLLAHLKKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYI 408
GHEG GSLL+ LK GW N L G ++G FF +++DLT+ GL H D+I+ +FQYI
Sbjct: 339 GHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYI 398
Query: 409 EMLKNSLPQKWIFNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILAMGLLT 468
+ L+ PQ+W+F E +D++ F+FK P S +A L Y + A LL
Sbjct: 399 QKLRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGKLHY-YPLNGVLTAEYLLE 457
Query: 469 KYEPDLLTQYTDALVPENSRVTLISRSLE--TDSAEKWYGTAYKVVDYPADLIKNMKSPG 526
++ PDL+ D L PEN RV ++S+S E TD E+WYGT YK P D+I+ ++
Sbjct: 458 EFRPDLIDMVLDKLRPENVRVAIVSKSFEGKTDRTEQWYGTQYKQEAIPEDVIQKWQNAD 517
Query: 527 LNPALTLPRPNEFVSTNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYL 586
LN LP NEF+ TNF++ ++ P L+ +SKLW+K+DD+F+ P+ +
Sbjct: 518 LNGKFKLPTKNEFIPTNFEILALEKDATP-YPALIKDTAMSKLWFKQDDKFFLPKACLNF 576
Query: 587 SFKLPHTHASIINSMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNE 646
F P + ++ ++ LY +L D+L + Y A A L T G+ ++ G+N+
Sbjct: 577 EFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYND 636
Query: 647 KLIILLTRFLQGVNSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWS 706
K ILL + + + +FE K RFEI+K+ +R L N E P+ Y ++ E +W+
Sbjct: 637 KQPILLKKITEKMATFEIDKKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWT 696
Query: 707 TAEKLQVFEKLTFEQLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPN---NI 763
E + + +T +L FIP + ++ E L+HGNI + AL V +++ +
Sbjct: 697 KDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGVMQMVEDTLIEHAHTK 756
Query: 764 HNLQVSNNRLRSYLLPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFAQL 823
L R R LP F Y+ ++ + N I+ Q D+ S + LF Q+
Sbjct: 757 PLLPSQLVRYREVQLPDRGWFVYQR--RNEVHNNCGIEIYYQTDMQSTSENMFLELFCQI 814
Query: 824 IHEPCFDTLRTKEQLGYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVL 883
I EPCF+TLRTKEQLGY+VFS +G +R +IQSE YLE R+ F T + +
Sbjct: 815 ISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKAI 874
Query: 884 RDMPEEDFEKHKEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQ 943
DM EE F+KH +AL L K K ++ E A+Y I YN+ + + ++K
Sbjct: 875 EDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNYDRDNIEVAYLKTLSKD 934
Query: 944 QMIDFYEN--YIMSENASKLILHLKSQ---------VENKELNENELDTAKYPTGQLIED 992
+I FY+ + + K+ +H+ ++ + + N + P ++I +
Sbjct: 935 DIIKFYKEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPSQNDINLSEAPPLPQPEVIHN 994
Query: 993 VGAFKSTLFVAPVRQPMKDF 1012
+ FK L + P+ +P +F
Sbjct: 995 MTEFKRGLPLFPLVKPHINF 1014
>dbj|BAF62161.1| insulin-degrading enzyme [Danio rerio]
Length = 998
Score = 1104 bits (2855), Expect = 0.0, Method: Composition-based stats.
Identities = 373/989 (37%), Positives = 576/989 (58%), Gaps = 20/989 (2%)
Query: 40 TCLSRYYTTNPYNMTSNFKTFNLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAAS 99
+ R T + K D ++ D+R YR +E N LKA+LI DP DK++A+
Sbjct: 9 RSIRRVSTLSIRMSDPAVKRVVSDIIRSPEDKREYRGLESTNGLKAILISDPTTDKSSAA 68
Query: 100 LDVNIGAFEDPKNLPGLAHFCEHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNY 159
LDV++G+ DP+N+ GLAHFCEH+LF+G+EK+P ENEYS +LS+H GSSNA+T+ ++TNY
Sbjct: 69 LDVHMGSLSDPENISGLAHFCEHMLFLGTEKYPKENEYSQFLSEHAGSSNAFTSGEHTNY 128
Query: 160 FFEVNHQHLFGALDRFSGFFSCPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLT 219
+F+V+H+HL GALDRF+ FF CPLF++ D+E+NAV+SE++KNL ND WR++QL+K+
Sbjct: 129 YFDVSHEHLQGALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNLMNDAWRLFQLEKATG 188
Query: 220 NTKHPYHKFSTGNIETLGTLPKENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSD 279
N KHP+ KF TGN TL T P + G+++R+ELLKFH +YS+NLM LC+LGRE LD L+
Sbjct: 189 NPKHPFSKFGTGNKLTLETRPSQQGIDIREELLKFHSTYYSSNLMGLCVLGRETLDELTS 248
Query: 280 WTYDLFKDVANNGREVPLYAEPIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESK 339
LF +V N VP + Q EHL++ +V P+KD++ L ++F +PD++++++S
Sbjct: 249 MVVKLFGEVENKNVPVPEFPTHPFQEEHLRQFYKVVPIKDIRNLYVTFPIPDLQKYYKSN 308
Query: 340 PPRILSHLIGHEGSGSLLAHLKKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRD 399
P L HLIGHEG GSLL+ LK GW N L G ++G FF +++DLT+ GL H D
Sbjct: 309 PGHYLGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVED 368
Query: 400 VIVLIFQYIEMLKNSLPQKWIFNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVS 459
+I +FQYI+ L+ PQ+W+F E +D++ F+FK P S +A L Y
Sbjct: 369 IIFHMFQYIQKLRTEGPQEWVFQECKDLNTVAFRFKDKERPRGYTSKVAGLLHY-YPLEE 427
Query: 460 RILAMGLLTKYEPDLLTQYTDALVPENSRVTLISRSLE--TDSAEKWYGTAYKVVDYPAD 517
+ A LL ++ PDL+ D L PEN RV ++S+S E TD E+WYGT YK +
Sbjct: 428 ILAAEYLLEEFRPDLIEMVLDKLRPENVRVAVVSKSFEGQTDRTEEWYGTQYKQEAITDE 487
Query: 518 LIKNMKSPGLNPALTLPRPNEFVSTNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRF 577
IK + LN LP NEF+ TNF++ ++ P P L+ +SK+W+K+DD+F
Sbjct: 488 AIKKWDNADLNGKFKLPMKNEFIPTNFEIYPLEKDSPSA-PTLIKDTAMSKVWFKQDDKF 546
Query: 578 WQPRGYIYLSFKLPHTHASIINSMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGL 637
+ P+ + F P + ++ ++ LY +L D+L + Y A A L T G+
Sbjct: 547 FLPKACLNFEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTVYGM 606
Query: 638 AITASGFNEKLIILLTRFLQGVNSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYN 697
++ G+N+K ILL + ++ + +FE + RF+I+K+ +R L N E P+ Y
Sbjct: 607 YLSVKGYNDKQHILLKKIIEKMATFEIDEKRFDIIKEAYMRPLNNFRAEQPHQHAMYYLR 666
Query: 698 AIINERSWSTAEKLQVFEKLTFEQLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKS 757
++ E +W+ E + +T +L FIP + ++ E L+HGNI + ALE+ +++
Sbjct: 667 LLMTEVAWTKDELRDALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQSALEMMQMLED 726
Query: 758 LIPN---NIHNLQVSNNRLRSYLLPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLS 814
+ L R R +P G + Y+ ++ + N I+ Q D+ + +
Sbjct: 727 TLIEHAHTKPLLPSQLIRYREVQVPDGGWYVYQQ--RNEVHNNCGIEIYYQTDMQNTHEN 784
Query: 815 ALSGLFAQLIHEPCFDTLRTKEQLGYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINN 874
L LF Q+I EPCF+TLRTKEQLGY+VFS +G +R +IQSE YLE R+
Sbjct: 785 MLLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRANGVQGLRFIIQSEKAPHYLESRVEA 844
Query: 875 FYETFGQVLRDMPEEDFEKHKEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKA 934
F +T + + +M +E F+KH +AL L K K +A E A+Y I YNF +
Sbjct: 845 FLKTMEKSVEEMGDEAFQKHIQALAIRRLDKPKKLAAECAKYWGEIISQQYNFDRDNIEV 904
Query: 935 KLVANITKQQMIDFYENY--IMSENASKLILHLKSQ------VENKELNENELDTAK--- 983
+ +TK+ ++ FY + I + K+ +H+ S+ + + +N+++ A
Sbjct: 905 AYLKTLTKEHIMQFYRDLLAIDAPRRHKVSVHVLSREMDSCPLVGEFPAQNDVNLAPAPS 964
Query: 984 YPTGQLIEDVGAFKSTLFVAPVRQPMKDF 1012
P L++D+ FK +L + P+ +P +F
Sbjct: 965 LPQPSLVQDMTEFKRSLPLFPLTKPHINF 993
>ref|XP_001146582.1| PREDICTED: insulysin isoform 3 [Pan troglodytes]
Length = 1019
Score = 1103 bits (2853), Expect = 0.0, Method: Composition-based stats.
Identities = 367/981 (37%), Positives = 573/981 (58%), Gaps = 20/981 (2%)
Query: 48 TNPYNMTSNFKTFNLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAF 107
T K K D+R YR +EL N +K LLI DP DK++A+LDV+IG+
Sbjct: 38 TYSKMNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSL 97
Query: 108 EDPKNLPGLAHFCEHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQH 167
DP N+ GL+HFCEH+LF+G++K+P ENEYS +LS+H GSSNA+T+ ++TNY+F+V+H+H
Sbjct: 98 SDPPNIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEH 157
Query: 168 LFGALDRFSGFFSCPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHK 227
L GALDRF+ FF CPLF++ D+E+NAV+SE++KN+ ND WR++QL+K+ N KHP+ K
Sbjct: 158 LEGALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSK 217
Query: 228 FSTGNIETLGTLPKENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKD 287
F TGN TL T P + G++VR ELLKFH +YS+NLM +C+LGRE LD L++ LF +
Sbjct: 218 FGTGNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSE 277
Query: 288 VANNGREVPLYAEPIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHL 347
V N +P + E Q EHL+++ ++ P+KD++ L ++F +PD++++++S P L HL
Sbjct: 278 VENKNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHL 337
Query: 348 IGHEGSGSLLAHLKKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQY 407
IGHEG GSLL+ LK GW N L G ++G FF +++DLT+ GL H D+I+ +FQY
Sbjct: 338 IGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQY 397
Query: 408 IEMLKNSLPQKWIFNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILAMGLL 467
I+ L+ PQ+W+F E +D++ F+FK P S +A L Y + A LL
Sbjct: 398 IQKLRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHY-YPLEEVLTAEYLL 456
Query: 468 TKYEPDLLTQYTDALVPENSRVTLISRSLE--TDSAEKWYGTAYKVVDYPADLIKNMKSP 525
++ PDL+ D L PEN RV ++S+S E TD E+WYGT YK P ++IK ++
Sbjct: 457 EEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNA 516
Query: 526 GLNPALTLPRPNEFVSTNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIY 585
LN LP NEF+ TNF++ ++ + P L+ +SKLW+K+DD+F+ P+ +
Sbjct: 517 DLNGKFKLPTKNEFIPTNFEILPLE-KEATPYPALIKDTAMSKLWFKQDDKFFLPKACLN 575
Query: 586 LSFKLPHTHASIINSMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFN 645
F + +A ++ ++ L+ +L D LK+ Y A + L + ++ G+N
Sbjct: 576 FEFFSRYIYADPLHCNMTYLFIRLLKDDLKEYTYAARLSGLSYGIASGMNAILLSVKGYN 635
Query: 646 EKLIILLTRFLQGVNSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSW 705
+K ILL + ++ + +FE + RFEI+K+ +R L N E P+ Y ++ E +W
Sbjct: 636 DKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAW 695
Query: 706 STAEKLQVFEKLTFEQLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPN---N 762
+ E + + +T +L FIP + ++ E L+HGNI + AL + +++ +
Sbjct: 696 TKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHT 755
Query: 763 IHNLQVSNNRLRSYLLPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFAQ 822
L R R LP F Y+ ++ + N I+ Q D+ S + LF Q
Sbjct: 756 KPLLPSQLVRYREVQLPDRGWFVYQQ--RNEVHNNCGIEIYYQTDMQSTSENMFLELFCQ 813
Query: 823 LIHEPCFDTLRTKEQLGYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQV 882
+I EPCF+TLRTKEQLGY+VFS +G +R +IQSE YLE R+ F T +
Sbjct: 814 IISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKS 873
Query: 883 LRDMPEEDFEKHKEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITK 942
+ DM EE F+KH +AL L K K ++ E A+Y I YNF + + +TK
Sbjct: 874 IEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTK 933
Query: 943 QQMIDFYEN--YIMSENASKLILHLKSQ------VENKELNENELDTAK---YPTGQLIE 991
+ +I FY+ + + K+ +H+ ++ V + +N+++ ++ P ++I+
Sbjct: 934 EDIIKFYKEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQ 993
Query: 992 DVGAFKSTLFVAPVRQPMKDF 1012
++ FK L + P+ +P +F
Sbjct: 994 NMTEFKRGLPLFPLVKPHINF 1014
>sp|Q9JHR7|IDE_MOUSE Insulin-degrading enzyme (Insulysin) (Insulinase) (Insulin protease)
emb|CAC01233.1| insulin degrading enzyme [Mus musculus]
Length = 1019
Score = 1103 bits (2853), Expect = 0.0, Method: Composition-based stats.
Identities = 368/981 (37%), Positives = 565/981 (57%), Gaps = 20/981 (2%)
Query: 48 TNPYNMTSNFKTFNLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAF 107
T + +K D+R YR +EL N +K LLI DP DK++A+LDV+IG+
Sbjct: 38 TYSTMSNPAIQRIEDQIVKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSL 97
Query: 108 EDPKNLPGLAHFCEHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQH 167
DP N+PGL+HFCEH+LF+G++K+P ENEYS +LS+H GSSNA+T+ ++TNY+F+V+H+H
Sbjct: 98 SDPPNIPGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEH 157
Query: 168 LFGALDRFSGFFSCPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHK 227
L GALDRF+ FF CPL + D+E+NAV+SE++KN+ ND WR++QL+K+ N KHP+ K
Sbjct: 158 LEGALDRFAQFFLCPLLDASCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSK 217
Query: 228 FSTGNIETLGTLPKENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKD 287
F TGN TL T P + G++VR+ELLKFH +YS+NLM +C+LGRE LD L++ LF +
Sbjct: 218 FGTGNKYTLETRPNQEGIDVREELLKFHSTYYSSNLMAICVLGRESLDDLTNLVVKLFSE 277
Query: 288 VANNGREVPLYAEPIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHL 347
V N +P + E Q EHL+++ ++ P+KD++ L ++F +PD++++++S P L HL
Sbjct: 278 VENKNVPLPEFPEHPFQEEHLRQLYKIVPIKDIRNLYVTFPIPDLQQYYKSNPGYYLGHL 337
Query: 348 IGHEGSGSLLAHLKKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQY 407
IGHEG GSLL+ LK GW N L G ++G FF +++DLT+ GL H D+I+ +FQY
Sbjct: 338 IGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQY 397
Query: 408 IEMLKNSLPQKWIFNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILAMGLL 467
I+ L+ PQ+W+F E +D++ F+FK P S +A L Y + A LL
Sbjct: 398 IQKLRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGKLHY-YPLNGVLTAEYLL 456
Query: 468 TKYEPDLLTQYTDALVPENSRVTLISRSLE--TDSAEKWYGTAYKVVDYPADLIKNMKSP 525
++ PDL+ D L PEN RV ++S+S E TD E+WYGT YK P D+I+ ++
Sbjct: 457 EEFRPDLIDMVLDKLRPENVRVAIVSKSFEGKTDRTEQWYGTQYKQEAIPEDVIQKWQNA 516
Query: 526 GLNPALTLPRPNEFVSTNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIY 585
LN LP NEF+ TNF++ ++ P L+ +SKLW+K+DD+F+ P+ +
Sbjct: 517 DLNGKFKLPTKNEFIPTNFEILSLEKDATP-YPALIKDTAMSKLWFKQDDKFFLPKACLN 575
Query: 586 LSFKLPHTHASIINSMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFN 645
F P + ++ ++ LY +L D+L + Y A A L T G+ ++ +N
Sbjct: 576 FEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKRYN 635
Query: 646 EKLIILLTRFLQGVNSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSW 705
+K ILL + + + +FE K RFEI+K+ +R L N E P+ Y ++ E +W
Sbjct: 636 DKQPILLKKITEKMATFEIDKKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAW 695
Query: 706 STAEKLQVFEKLTFEQLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPN---N 762
+ E + + +T +L FIP + ++ E L+HGNI + AL V +++ +
Sbjct: 696 TKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGVMQMVEDTLIEHAHT 755
Query: 763 IHNLQVSNNRLRSYLLPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFAQ 822
L R R LP F Y+ ++ + N I+ Q D+ S + LF Q
Sbjct: 756 KPLLPSQLVRYREVQLPDRGWFVYQQ--RNEVHNNCGIEIYYQTDMQSTSENMFLELFCQ 813
Query: 823 LIHEPCFDTLRTKEQLGYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQV 882
+I EPCF+TLRTKEQLGY+VFS +G +R +IQSE YLE R+ F T +
Sbjct: 814 IISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKA 873
Query: 883 LRDMPEEDFEKHKEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITK 942
+ DM EE F+KH +AL L K K ++ E A+Y I YN+ + + +TK
Sbjct: 874 IEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNYDRDNIEVAYLKTLTK 933
Query: 943 QQMIDFYEN--YIMSENASKLILHLKSQ---------VENKELNENELDTAKYPTGQLIE 991
+I FY+ + + K+ +H+ ++ + + N + P ++I
Sbjct: 934 DDIIRFYQEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPSQNDINLSEAPPLPQPEVIH 993
Query: 992 DVGAFKSTLFVAPVRQPMKDF 1012
++ FK L + P+ +P +F
Sbjct: 994 NMTEFKRGLPLFPLVKPHINF 1014
>ref|NP_001082994.1| insulin-degrading enzyme [Danio rerio]
gb|AAI39608.1| Zgc:162603 protein [Danio rerio]
Length = 978
Score = 1102 bits (2852), Expect = 0.0, Method: Composition-based stats.
Identities = 371/977 (37%), Positives = 572/977 (58%), Gaps = 20/977 (2%)
Query: 52 NMTSNFKTFNLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPK 111
K D ++ D+R YR +E N LKA+LI DP DK++A+LDV++G+ DP+
Sbjct: 1 MSDPAVKRVVSDIIRSPEDKREYRGLEFTNGLKAILISDPTTDKSSAALDVHMGSLSDPE 60
Query: 112 NLPGLAHFCEHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGA 171
N+ GLAHFCEH+LF+G+EK+P ENEYS +LS+H GSSNA+T+ ++TNY+F+V+H+HL GA
Sbjct: 61 NISGLAHFCEHMLFLGTEKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLQGA 120
Query: 172 LDRFSGFFSCPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTG 231
LDRF+ FF CPLF++ D+E+NAV+SE++KNL ND WR++QL+K+ N KHP+ KF TG
Sbjct: 121 LDRFAQFFLCPLFDESCKDREVNAVDSEHEKNLMNDAWRLFQLEKATGNPKHPFSKFGTG 180
Query: 232 NIETLGTLPKENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANN 291
N TL T P + G+++R+ELLKFH +YS+NLM LC+LGRE LD L+ LF +V N
Sbjct: 181 NKLTLETRPSQQGIDIREELLKFHSTYYSSNLMGLCVLGRETLDELTSMVVKLFGEVENK 240
Query: 292 GREVPLYAEPIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHE 351
VP + Q EHL++ +V P+KD++ L ++F +PD++++++S P L HLIGHE
Sbjct: 241 NVPVPEFPTHPFQEEHLRQFYKVVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHE 300
Query: 352 GSGSLLAHLKKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEML 411
G GSLL+ LK GW N L G ++G FF +++DLT+ GL H D+I +FQYI+ L
Sbjct: 301 GPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIIFHMFQYIQKL 360
Query: 412 KNSLPQKWIFNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILAMGLLTKYE 471
+ PQ+W+F E +D++ F+FK P S +A L Y + A LL ++
Sbjct: 361 RTEGPQEWVFQECKDLNTVAFRFKDKERPRGYTSKVAGLLHY-YPLEEILAAEYLLEEFR 419
Query: 472 PDLLTQYTDALVPENSRVTLISRSLE--TDSAEKWYGTAYKVVDYPADLIKNMKSPGLNP 529
PDL+ D L PEN RV ++S+S E TD E+WYGT YK + IK + LN
Sbjct: 420 PDLIEMVLDKLRPENVRVAVVSKSFEGQTDRTEEWYGTQYKQEAITDEAIKKWDNADLNG 479
Query: 530 ALTLPRPNEFVSTNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFK 589
LP NEF+ TNF++ ++ P P L+ +SK+W+K+DD+F+ P+ + F
Sbjct: 480 KFKLPMKNEFIPTNFEIYPLEKDSPSA-PTLIKDTAMSKVWFKQDDKFFLPKACLNFEFF 538
Query: 590 LPHTHASIINSMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLI 649
P + ++ ++ LY +L D+L + Y A A L T G+ ++ G+N+K
Sbjct: 539 SPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTVYGMYLSVKGYNDKQH 598
Query: 650 ILLTRFLQGVNSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAE 709
ILL + ++ + +FE + RF+I+K+ +R L N E P+ Y ++ E +W+ E
Sbjct: 599 ILLKKIIEKMATFEIDEKRFDIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDE 658
Query: 710 KLQVFEKLTFEQLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPN---NIHNL 766
+ +T +L FIP + ++ E L+HGNI + ALE+ +++ + L
Sbjct: 659 LRDALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQSALEMMQMLEDTLIEHAHTKPLL 718
Query: 767 QVSNNRLRSYLLPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFAQLIHE 826
R R +P G + Y+ ++ + N I+ Q D+ + + L LF Q+I E
Sbjct: 719 PSQLIRYREVQVPDGGWYVYQQ--RNEVHNNCGIEIYYQTDMQNTHENMLLELFCQIISE 776
Query: 827 PCFDTLRTKEQLGYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVLRDM 886
PCF+TLRTKEQLGY+VFS +G +R +IQSE YLE R+ F +T + + +M
Sbjct: 777 PCFNTLRTKEQLGYIVFSGPRRANGVQGLRFIIQSEKAPHYLESRVEAFLKTMEKSVEEM 836
Query: 887 PEEDFEKHKEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMI 946
+E F+KH +AL L K K +A E A+Y I YNF + + +TK+ ++
Sbjct: 837 GDEAFQKHIQALAIRRLDKPKKLAAECAKYWGEIISQQYNFDRDNIEVAYLKTLTKEHIM 896
Query: 947 DFYENY--IMSENASKLILHLKSQ------VENKELNENELDTAK---YPTGQLIEDVGA 995
FY + I + K+ +H+ S+ + + +N+++ A P L++D+
Sbjct: 897 QFYRDLLAIDAPRRHKVSVHVLSREMDSCPLVGEFPAQNDVNLAPAPSLPQPSLVQDMTE 956
Query: 996 FKSTLFVAPVRQPMKDF 1012
FK +L + P+ +P +F
Sbjct: 957 FKRSLPLFPLTKPHINF 973
>gb|EDL41785.1| insulin degrading enzyme [Mus musculus]
Length = 978
Score = 1102 bits (2850), Expect = 0.0, Method: Composition-based stats.
Identities = 369/977 (37%), Positives = 566/977 (57%), Gaps = 20/977 (2%)
Query: 52 NMTSNFKTFNLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPK 111
+ +K D+R YR +EL N +K LLI DP DK++A+LDV+IG+ DP
Sbjct: 1 MSNPAIQRIEDQIVKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPP 60
Query: 112 NLPGLAHFCEHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGA 171
N+PGL+HFCEH+LF+G++K+P ENEYS +LS+H GSSNA+T+ ++TNY+F+V+H+HL GA
Sbjct: 61 NIPGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGA 120
Query: 172 LDRFSGFFSCPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTG 231
LDRF+ FF CPLF+ D+E+NAV+SE++KN+ ND WR++QL+K+ N KHP+ KF TG
Sbjct: 121 LDRFAQFFLCPLFDASCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTG 180
Query: 232 NIETLGTLPKENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANN 291
N TL T P + G++VR+ELLKFH +YS+NLM +C+LGRE LD L++ LF +V N
Sbjct: 181 NKYTLETRPNQEGIDVREELLKFHSTYYSSNLMAICVLGRESLDDLTNLVVKLFSEVENK 240
Query: 292 GREVPLYAEPIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHE 351
+P + E Q EHL+++ ++ P+KD++ L ++F +PD++++++S P L HLIGHE
Sbjct: 241 NVPLPEFPEHPFQEEHLRQLYKIVPIKDIRNLYVTFPIPDLQQYYKSNPGHYLGHLIGHE 300
Query: 352 GSGSLLAHLKKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEML 411
G GSLL+ LK GW N L G ++G FF +++DLT+ GL H D+I+ +FQYI+ L
Sbjct: 301 GPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKL 360
Query: 412 KNSLPQKWIFNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILAMGLLTKYE 471
+ PQ+W+F E +D++ F+FK P S +A L Y + A LL ++
Sbjct: 361 RAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGKLHY-YPLNGVLTAEYLLEEFR 419
Query: 472 PDLLTQYTDALVPENSRVTLISRSLE--TDSAEKWYGTAYKVVDYPADLIKNMKSPGLNP 529
PDL+ D L PEN RV ++S+S E TD E+WYGT YK P D+I+ ++ LN
Sbjct: 420 PDLIDMVLDKLRPENVRVAIVSKSFEGKTDRTEQWYGTQYKQEAIPEDIIQKWQNADLNG 479
Query: 530 ALTLPRPNEFVSTNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFK 589
LP NEF+ TNF++ ++ P L+ +SKLW+K+DD+F+ P+ + F
Sbjct: 480 KFKLPTKNEFIPTNFEILSLEKDATP-YPALIKDTAMSKLWFKQDDKFFLPKACLNFEFF 538
Query: 590 LPHTHASIINSMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLI 649
P + ++ ++ LY +L D+L + Y A A L T G+ ++ G+N+K
Sbjct: 539 SPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQP 598
Query: 650 ILLTRFLQGVNSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAE 709
ILL + + + +FE K RFEI+K+ +R L N E P+ Y ++ E +W+ E
Sbjct: 599 ILLKKITEKMATFEIDKKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDE 658
Query: 710 KLQVFEKLTFEQLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPN---NIHNL 766
+ + +T +L FIP + ++ E L+HGNI + AL V +++ + L
Sbjct: 659 LKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGVMQMVEDTLIEHAHTKPLL 718
Query: 767 QVSNNRLRSYLLPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFAQLIHE 826
R R LP F Y+ ++ + N I+ Q D+ S + LF Q+I E
Sbjct: 719 PSQLVRYREVQLPDRGWFVYQQ--RNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISE 776
Query: 827 PCFDTLRTKEQLGYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVLRDM 886
PCF+TLRTKEQLGY+VFS +G +R +IQSE YLE R+ F T + + DM
Sbjct: 777 PCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKAIEDM 836
Query: 887 PEEDFEKHKEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMI 946
EE F+KH +AL L K K ++ E A+Y I YN+ + + +TK +I
Sbjct: 837 TEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNYDRDNIEVAYLKTLTKDDII 896
Query: 947 DFYEN--YIMSENASKLILHLKSQ---------VENKELNENELDTAKYPTGQLIEDVGA 995
FY+ + + K+ +H+ ++ + + N + P ++I ++
Sbjct: 897 RFYQEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPSQNDINLSEAPPLPQPEVIHNMTE 956
Query: 996 FKSTLFVAPVRQPMKDF 1012
FK L + P+ +P +F
Sbjct: 957 FKRGLPLFPLVKPHINF 973
>ref|XP_001276340.1| a-pheromone processing metallopeptidase Ste23 [Aspergillus clavatus
NRRL 1]
gb|EAW14914.1| a-pheromone processing metallopeptidase Ste23 [Aspergillus clavatus
NRRL 1]
Length = 1156
Score = 1094 bits (2829), Expect = 0.0, Method: Composition-based stats.
Identities = 392/992 (39%), Positives = 584/992 (58%), Gaps = 18/992 (1%)
Query: 2 GVSLLASSSAFVTKPLLTQLVHLSPISLNFTVRRFKPFTCLSRYYTTNPYNMTSNFKTFN 61
++ A + F + L + L P+ ++T R F C ++ M S +
Sbjct: 33 TLASAAIAPPFSSSLRLRPICSLHPLPGSWTRRSFSRSAC--APFSAGNLTMGS-IEHLT 89
Query: 62 LDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNLPGLAHFCE 121
KP+LD+RSYR I LPNKL+ALL+ DP DKA+AS++VN+G F D ++PG+AH E
Sbjct: 90 ESLEKPELDDRSYRVIRLPNKLEALLVHDPDTDKASASVNVNVGNFSDADDMPGMAHAVE 149
Query: 122 HLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGALDRFSGFFSC 181
HLLFMG++KFP EN Y+ YL+ H GSSNAYTA+ TNYFFE L+GALDRF+ FF
Sbjct: 150 HLLFMGTKKFPKENAYNQYLASHSGSSNAYTAATETNYFFE-PSSPLYGALDRFAQFFVS 208
Query: 182 PLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGTLPK 241
PLF + + D+E+ AV+SENKKNLQ+D+WR+ QL+KSL+N HPYH FSTGN++TL P+
Sbjct: 209 PLFLESTLDRELRAVDSENKKNLQSDLWRLMQLNKSLSNPGHPYHHFSTGNLKTLKEDPE 268
Query: 242 ENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGREVPLYA-E 300
+ GL VR E +KF++ YSAN M+LC+LGRE LD L W +LF +V N +
Sbjct: 269 KRGLEVRSEFIKFYEKHYSANRMRLCVLGRESLDELEKWVEELFSEVENKDLPQNRWDDV 328
Query: 301 PIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGSGSLLAHL 360
+PE L I +PV D + L+I F D E +ES+P R +SHLIGHEG GS+LA++
Sbjct: 329 QPWRPEDLGVQIFAKPVMDNRSLDIYFPFLDEEYLYESQPSRYISHLIGHEGPGSILAYI 388
Query: 361 KKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLPQKWI 420
K GWAN LSAG + G+A F + I LT GL YR+V ++F+YI MLK PQ+W+
Sbjct: 389 KAKGWANGLSAGVMPICPGSAAFTISIRLTKEGLQQYREVAKVVFEYIAMLKEREPQQWV 448
Query: 421 FNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILAMGLLTKYEPDLLTQYTD 480
F+E+++++ F+FKQ S S L+ ++K +P +L+ LL K++P+L+ +
Sbjct: 449 FDEMKNLAEVEFRFKQKSPASRFTSRLSSVMQKP-MPREWLLSGSLLRKFDPELIKKALA 507
Query: 481 ALVPENSRVTLISRSLE--TDSAEKWYGTAYKVVDYPADLIKNMKSP------GLNPALT 532
L P+N R+ ++S+ DS EKWYGT YKV P D + ++K+ L
Sbjct: 508 CLQPDNFRMIVVSQEHPGDWDSKEKWYGTEYKVQKLPQDFMADIKNALATTPETRLSELH 567
Query: 533 LPRPNEFVSTNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLPH 592
+P NEFV T V+K D +P P L+ D+ +LW+KKDDRFW P+G ++++ + P
Sbjct: 568 MPHENEFVPTRLSVEKKDISEPAKTPKLIRHDEHVRLWFKKDDRFWVPKGTVHITLRNPL 627
Query: 593 THASIINSMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLIILL 652
A+ N + S LY +L DAL + YDA A L + + GL I+ G+N+K+ +LL
Sbjct: 628 AWATPANLVKSKLYCELVKDALVEYSYDAELAGLDYHLSASVFGLDISVGGYNDKMAVLL 687
Query: 653 TRFLQGVNSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKLQ 712
+ L + DRF I+K++ R +N Y+ P+ Q+ +Y + E++W +
Sbjct: 688 EKVLTSMRDLVVNPDRFHIIKERLSRGYRNAEYQQPFYQVGDYTRHLTAEKTWINEQYAA 747
Query: 713 VFEKLTFEQLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIHNLQVSNNR 772
E + E + NF P + + + E L HGN+ E+AL + L+++++ + + R
Sbjct: 748 ELEHIEPEDISNFFPQLLQQNHVEVLAHGNLYKEDALRMTDLVENVLQSRPLPQSQWHVR 807
Query: 773 LRSYLLPKGKTFRYETALKDSQNVNSCIQHVTQLDV-YSEDLSALSGLFAQLIHEPCFDT 831
R+ ++P G + YE L+D NVN CI++ + + L A LFAQ+ EP FD
Sbjct: 808 -RNIIIPPGSNYVYERTLQDPANVNHCIEYYVYVGSIRDDILRAKLLLFAQMTDEPAFDQ 866
Query: 832 LRTKEQLGYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVLRDMPEEDF 891
LR+KEQLGYVV+S + + T R++IQSE T YLE RI+NF G+ L +M ++DF
Sbjct: 867 LRSKEQLGYVVWSGARYSATTIGYRVIIQSERTAEYLESRIDNFLIQAGETLENMSDKDF 926
Query: 892 EKHKEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMIDFYEN 951
E HK ++ N L+K KN++ E++R+ + I ++F + A V +TK ++DFY+
Sbjct: 927 EGHKRSVVNKRLEKLKNLSSETSRFWSHIGSEYFDFVQNETDAANVRTLTKADIVDFYKQ 986
Query: 952 YI--MSENASKLILHLKSQVENKELNENELDT 981
I S KL ++L +Q + +
Sbjct: 987 LIDPRSPTRGKLSIYLNAQAGGHTHTIDPKEQ 1018
>pdb|2WBY|A Chain A, Crystal Structure Of Human Insulin-Degrading Enzyme In
Complex With Insulin
pdb|2WBY|B Chain B, Crystal Structure Of Human Insulin-Degrading Enzyme In
Complex With Insulin
pdb|2WC0|A Chain A, Crystal Structure Of Human Insulin Degrading Enzyme In
Complex With Iodinated Insulin
pdb|2WC0|B Chain B, Crystal Structure Of Human Insulin Degrading Enzyme In
Complex With Iodinated Insulin
Length = 990
Score = 1092 bits (2824), Expect = 0.0, Method: Composition-based stats.
Identities = 368/978 (37%), Positives = 570/978 (58%), Gaps = 20/978 (2%)
Query: 51 YNMTSNFKTFNLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDP 110
K K D+R YR +EL N +K LLI DP DK++A+LDV+IG+ DP
Sbjct: 12 PMNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDP 71
Query: 111 KNLPGLAHFCEHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFG 170
N+ GL+HF +H+LF+G++K+P ENEYS +LS+H GSSNA+T+ ++TNY+F+V+H+HL G
Sbjct: 72 PNIAGLSHFLQHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEG 131
Query: 171 ALDRFSGFFSCPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFST 230
ALDRF+ FF PLF++ + D+E+NAV+SE++KN+ ND WR++QL+K+ N KHP+ KF T
Sbjct: 132 ALDRFAQFFLSPLFDESAKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGT 191
Query: 231 GNIETLGTLPKENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVAN 290
GN TL T P + G++VR ELLKFH +YS+NLM + +LGRE LD L++ LF +V N
Sbjct: 192 GNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVVVLGRESLDDLTNLVVKLFSEVEN 251
Query: 291 NGREVPLYAEPIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGH 350
+P + E Q EHL+++ ++ P+KD++ L ++F +PD++++++S P L HLIGH
Sbjct: 252 KNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGH 311
Query: 351 EGSGSLLAHLKKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEM 410
EG GSLL+ LK GW N L G ++G FF +++DLT+ GL H D+I+ +FQYI+
Sbjct: 312 EGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQK 371
Query: 411 LKNSLPQKWIFNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILAMGLLTKY 470
L+ PQ+W+F EL+D++ F+FK P S +A L Y + A LL ++
Sbjct: 372 LRAEGPQEWVFQELKDLNAVAFRFKDKERPRGYTSKIAGILHY-YPLEEVLTAEYLLEEF 430
Query: 471 EPDLLTQYTDALVPENSRVTLISRSLE--TDSAEKWYGTAYKVVDYPADLIKNMKSPGLN 528
PDL+ D L PEN RV ++S+S E TD E+WYGT YK P ++IK ++ LN
Sbjct: 431 RPDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLN 490
Query: 529 PALTLPRPNEFVSTNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSF 588
LP NEF+ TNF++ ++ + P L+ +SKLW+K+DD+F+ P+ + F
Sbjct: 491 GKFKLPTKNEFIPTNFEILPLE-KEATPYPALIKDTAMSKLWFKQDDKFFLPKANLNFEF 549
Query: 589 KLPHTHASIINSMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKL 648
P + ++S ++ LY +L D+L + Y A A L T G+ ++ G+N+K
Sbjct: 550 FSPFAYVDPLHSNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQ 609
Query: 649 IILLTRFLQGVNSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTA 708
ILL + ++ + +FE + RFEI+K+ +R L N E P+ Y ++ E +W+
Sbjct: 610 PILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKD 669
Query: 709 EKLQVFEKLTFEQLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPN---NIHN 765
E + + +T +L FIP + ++ E L+HGNI + AL + +++ +
Sbjct: 670 ELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPL 729
Query: 766 LQVSNNRLRSYLLPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFAQLIH 825
L R R LP F Y+ ++ + NS I+ Q D+ S + LFAQ+I
Sbjct: 730 LPSQLVRYREVQLPDRGWFVYQQ--RNEVHNNSGIEIYYQTDMQSTSENMFLELFAQIIS 787
Query: 826 EPCFDTLRTKEQLGYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVLRD 885
EP F+TLRTKEQLGY+VFS +G +R +IQSE YLE R+ F T + + D
Sbjct: 788 EPAFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIED 847
Query: 886 MPEEDFEKHKEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQM 945
M EE F+KH +AL L K K ++ ESA+Y I YNF + + +TK+ +
Sbjct: 848 MTEEAFQKHIQALAIRRLDKPKKLSAESAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDI 907
Query: 946 IDFYEN--YIMSENASKLILHLKSQVENK---------ELNENELDTAKYPTGQLIEDVG 994
I FY+ + + K+ +H+ ++ + + + N P ++I+++
Sbjct: 908 IKFYKEMLAVDAPRRHKVSVHVLAREMDSNPVVGEFPAQNDINLSQAPALPQPEVIQNMT 967
Query: 995 AFKSTLFVAPVRQPMKDF 1012
FK L + P+ +P +F
Sbjct: 968 EFKRGLPLFPLVKPHINF 985
>sp|P14735|IDE_HUMAN Insulin-degrading enzyme (Insulysin) (Insulinase) (Insulin protease)
gb|AAA52712.1| insulin-degrading enzyme
Length = 1019
Score = 1091 bits (2822), Expect = 0.0, Method: Composition-based stats.
Identities = 368/981 (37%), Positives = 574/981 (58%), Gaps = 20/981 (2%)
Query: 48 TNPYNMTSNFKTFNLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAF 107
T K K D+R YR +EL N +K LL+ DP DK++A+LDV+IG+
Sbjct: 38 TYSKMNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLMSDPTTDKSSAALDVHIGSL 97
Query: 108 EDPKNLPGLAHFCEHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQH 167
DP N+ GL+HFCEH+LF+G++K+P ENEYS +LS+H GSSNA+T+ ++TNY+F+V+H+H
Sbjct: 98 SDPPNIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEH 157
Query: 168 LFGALDRFSGFFSCPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHK 227
L GALDRF+ FF CPLF++ D+E+NAV+SE++KN+ ND WR++QL+K+ N KHP+ K
Sbjct: 158 LEGALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSK 217
Query: 228 FSTGNIETLGTLPKENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKD 287
F TGN TL T P + G++VR ELLKFH +YS+NLM +C+LGRE LD L++ LF +
Sbjct: 218 FGTGNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSE 277
Query: 288 VANNGREVPLYAEPIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHL 347
V N +P + E Q EHL+++ ++ P+KD++ L ++F +PD++++++S P L HL
Sbjct: 278 VENKNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHL 337
Query: 348 IGHEGSGSLLAHLKKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQY 407
IGHEG GSLL+ LK GW N L G ++G FF +++DLT+ GL H D+I+ +FQY
Sbjct: 338 IGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQY 397
Query: 408 IEMLKNSLPQKWIFNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILAMGLL 467
I+ L+ PQ+W+F E +D++ F+FK P S +A L Y + A LL
Sbjct: 398 IQKLRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHY-YPLEEVLTAEYLL 456
Query: 468 TKYEPDLLTQYTDALVPENSRVTLISRSLE--TDSAEKWYGTAYKVVDYPADLIKNMKSP 525
++ PDL+ D L PEN RV ++S+S E TD E+WYGT YK P ++IK ++
Sbjct: 457 EEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNA 516
Query: 526 GLNPALTLPRPNEFVSTNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIY 585
LN LP NEF+ TNF++ ++ + P L+ +SKLW+K+DD+ +P+ +
Sbjct: 517 DLNGKFKLPTKNEFIPTNFEILPLE-KEATPYPALIKDTVMSKLWFKQDDKKKKPKACLN 575
Query: 586 LSFKLPHTHASIINSMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFN 645
F P + ++ ++ LY +L D+L + Y A A L T G+ ++ G+N
Sbjct: 576 FEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYN 635
Query: 646 EKLIILLTRFLQGVNSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSW 705
+K ILL + ++ + +FE + RFEI+K+ +R L N E P+ Y ++ E +W
Sbjct: 636 DKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAW 695
Query: 706 STAEKLQVFEKLTFEQLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPN---N 762
+ E + + +T +L FIP + ++ E L+HGNI + AL + +++ +
Sbjct: 696 TKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHT 755
Query: 763 IHNLQVSNNRLRSYLLPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFAQ 822
L R R LP F Y+ ++ + N I+ Q D+ S + LF Q
Sbjct: 756 KPLLPSQLVRYREVQLPDRGWFVYQQ--RNEVHNNCGIEIYYQTDMQSTSENMFLELFCQ 813
Query: 823 LIHEPCFDTLRTKEQLGYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQV 882
+I EPCF+TLRTKEQLGY+VFS +G ++R +IQSE YLE R+ F T +
Sbjct: 814 IISEPCFNTLRTKEQLGYIVFSGPRRANGIQSLRFIIQSEKPPHYLESRVEAFLITMEKS 873
Query: 883 LRDMPEEDFEKHKEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITK 942
+ DM EE F+KH +AL L K K ++ E A+Y I YNF + + +TK
Sbjct: 874 IEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTK 933
Query: 943 QQMIDFYEN--YIMSENASKLILHLKSQ------VENKELNENELDTAK---YPTGQLIE 991
+ +I FY+ + + K+ +H+ ++ V + +N+++ ++ P ++I+
Sbjct: 934 EDIIKFYKEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQ 993
Query: 992 DVGAFKSTLFVAPVRQPMKDF 1012
++ FK L + P+ +P +F
Sbjct: 994 NMTEFKRGLPLFPLVKPHINF 1014
>ref|XP_001266332.1| a-pheromone processing metallopeptidase Ste23 [Neosartorya fischeri
NRRL 181]
gb|EAW24435.1| a-pheromone processing metallopeptidase Ste23 [Neosartorya fischeri
NRRL 181]
Length = 1155
Score = 1087 bits (2812), Expect = 0.0, Method: Composition-based stats.
Identities = 384/997 (38%), Positives = 579/997 (58%), Gaps = 18/997 (1%)
Query: 2 GVSLLASSSAFVTKPLLTQLVHLSPISLNFTVRRFKPFTCLSRYYTTNPYNMTSNFKTFN 61
++ A + F + P S +S ++ R T + +
Sbjct: 33 SIASTAIAPHFSSSPRRRLNCPQSLLSRCWSRRSLSRSTVAPFSAAA---VTMGSIQHIT 89
Query: 62 LDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNLPGLAHFCE 121
KP+LD+RSYR I L NKL+ALL+ DP+ DKA+AS++VN+G F D ++PG+AH E
Sbjct: 90 EHLEKPELDDRSYRVIRLSNKLEALLVHDPETDKASASVNVNVGNFSDADDMPGMAHAVE 149
Query: 122 HLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGALDRFSGFFSC 181
HLLFMG++KFP EN Y+ YL+ H GSSNAYTA+ TNYFFE L+GALDRF+ FF
Sbjct: 150 HLLFMGTKKFPKENAYNQYLASHSGSSNAYTAATETNYFFE-PSSPLYGALDRFAQFFVS 208
Query: 182 PLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGTLPK 241
PLF + + D+E+ AV+SENKKNLQ+D+WR+ QL+KSL+N HPYH FSTGN++TL P+
Sbjct: 209 PLFLESTLDRELRAVDSENKKNLQSDLWRLMQLNKSLSNPAHPYHHFSTGNLKTLKEDPQ 268
Query: 242 ENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGREVPLYA-E 300
+ GL VR E +KF++ YSAN M+LC+LGRE LD L W +LF +V N +
Sbjct: 269 QRGLEVRSEFIKFYQKHYSANRMRLCVLGRESLDELEKWVEELFSEVENKDLPQNRWDDV 328
Query: 301 PIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGSGSLLAHL 360
+ E L I +PV D + L+I F D E +ES+P R +SHLIGHEG GS+LA++
Sbjct: 329 QPWRDEDLGIQIFAKPVMDTRSLDIYFPFLDEETLYESQPSRYISHLIGHEGPGSILAYI 388
Query: 361 KKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLPQKWI 420
K GWAN LSAG + G A F + I LT GL YR+V ++FQYI MLK PQ+W+
Sbjct: 389 KAKGWANGLSAGVMPICPGAAAFTISIRLTKEGLQQYREVAKVVFQYIAMLKEREPQQWV 448
Query: 421 FNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILAMGLLTKYEPDLLTQYTD 480
F+E+++++ F+FKQ S S L+ ++K P +L+ LL K++PDL+ +
Sbjct: 449 FDEMKNLAEVEFRFKQKSPASRFTSRLSSVMQKPL-PREWLLSGSLLRKFDPDLIKKALS 507
Query: 481 ALVPENSRVTLISRSLE--TDSAEKWYGTAYKVVDYPADLIKNMKSP------GLNPALT 532
L P+N R+ ++S+ +S EKWYGT YKV P D + +++ L
Sbjct: 508 YLRPDNFRLIVVSQEYPGDWNSKEKWYGTEYKVGKIPQDFMADIREALDSTPETRLSELH 567
Query: 533 LPRPNEFVSTNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLPH 592
+P NEFV T V+K + +P P L+ DD +LW+KKDDRFW P+G ++++ + P
Sbjct: 568 MPHKNEFVPTRLSVEKKEVAEPAKTPKLIRHDDHVRLWFKKDDRFWVPKGTVHITLRNPL 627
Query: 593 THASIINSMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLIILL 652
A+ N + S LY +L DAL + YDA A L + + GL ++ G+N+K+ +LL
Sbjct: 628 AWATPANLVKSKLYCELVKDALVEYSYDAELAGLDYHLSASVFGLDVSVGGYNDKMAVLL 687
Query: 653 TRFLQGVNSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKLQ 712
+ + +RF I+K++ R +N Y+ P+ Q+ +Y + +E++W +
Sbjct: 688 EKVFTSMRDLVVNPNRFHIIKERLSRGYRNAEYQQPFYQVGDYTRYLTSEKTWINEQYAA 747
Query: 713 VFEKLTFEQLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIHNLQVSNNR 772
E + E + NF P + + E L HGN+ E+AL++ L+++++ + + R
Sbjct: 748 ELEHIDAEDISNFFPQLLSQNHIEVLAHGNLYKEDALKMTDLVENILQSRPLPQSQWHVR 807
Query: 773 LRSYLLPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSED-LSALSGLFAQLIHEPCFDT 831
R+ ++P G + YE L+D N+N CI++ + ++D L A LFAQ+ EP FD
Sbjct: 808 -RNIIIPPGSNYVYERTLRDPANINHCIEYYVYVGSITDDMLRAKLLLFAQMTDEPAFDQ 866
Query: 832 LRTKEQLGYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVLRDMPEEDF 891
LR+KEQLGYVV+S + + T R++IQSE T YLE RI+NF G+ L +M E+DF
Sbjct: 867 LRSKEQLGYVVWSGARYSATTIGYRVIIQSERTAEYLESRIDNFLIQTGETLENMSEKDF 926
Query: 892 EKHKEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMIDFYEN 951
E HK ++ N L+K KN++ E++R+ + I ++F + A V +TK ++DFY+
Sbjct: 927 EGHKRSVINKRLEKLKNLSSETSRFWSHIGSEYFDFLQNESDAANVRALTKADIVDFYKQ 986
Query: 952 YI--MSENASKLILHLKSQVENKELNENELDTAKYPT 986
+ S KL ++L +Q E + ++ +
Sbjct: 987 LLDPRSPTRGKLSIYLNAQGGAHAKVEGKDQQSRLVS 1023
>ref|XP_001847597.1| metalloprotease [Culex pipiens quinquefasciatus]
gb|EDS26498.1| metalloprotease [Culex pipiens quinquefasciatus]
Length = 998
Score = 1079 bits (2792), Expect = 0.0, Method: Composition-based stats.
Identities = 357/993 (35%), Positives = 572/993 (57%), Gaps = 21/993 (2%)
Query: 38 PFTCLSRYYTTNPYNMTSNFKTFNLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAA 97
L + TT P + ++ T D +K D R YR + L N LK LLI DP DK+A
Sbjct: 2 NAASLPKIATTAPVTVGADKLTRFDDIVKSQQDNRLYRGLRLSNGLKVLLISDPTTDKSA 61
Query: 98 ASLDVNIGAFEDPKNLPGLAHFCEHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNT 157
A+L V +G DP +PGLAHFCEH+LF+G++K+ +EN+Y ++LS++GGSSNA T + T
Sbjct: 62 AALAVEVGHLSDPDEIPGLAHFCEHMLFLGTKKYINENDYMAFLSENGGSSNAATYADTT 121
Query: 158 NYFFEVNHQHLFGALDRFSGFFSCPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKS 217
Y+F+V + L ALDRFS FF PLF + +T++EINAV+SE++KNL D+WRI Q++KS
Sbjct: 122 KYYFDVVPEKLQEALDRFSQFFIAPLFTESATEREINAVHSEHEKNLSMDVWRIRQVNKS 181
Query: 218 LTNTKHPYHKFSTGNIETLGTLPKENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTL 277
L + KHPY+KF TG+ +TL PK + +N+R+EL+KFH +YSAN+M L + G+E LD L
Sbjct: 182 LCDPKHPYNKFGTGSKKTLLEDPKLSKINIREELMKFHSKWYSANIMSLAVFGKESLDEL 241
Query: 278 SDWTYDLFKDVANNGREVPLYAEPIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWE 337
+F D+ N P + + + EHL V PVKD + L I+F D+E +++
Sbjct: 242 ESMVVSMFSDIENKNVTSPCWKDLPFKEEHLATKTTVVPVKDTRSLTITFQTEDLERYYK 301
Query: 338 SKPPRILSHLIGHEGSGSLLAHLKKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHY 397
+ P +SHLIGHEG+GS+L+ LK GW N L G T+ +G FF V +DLT +G H
Sbjct: 302 AGPEHYVSHLIGHEGAGSILSELKAKGWCNNLVGGYSTIGRGFGFFEVMVDLTQDGFDHV 361
Query: 398 RDVIVLIFQYIEMLKNSLPQKWIFNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIP 457
D++ +IFQYI MLK PQKWIF E D+ F+FK +P S VS++ ++ Y
Sbjct: 362 DDIVKIIFQYIHMLKTEGPQKWIFEEYCDLCEMQFRFKDKENPLSLVSNVVHSMQ-SYPL 420
Query: 458 VSRILAMGLLTKYEPDLLTQYTDALVPENSRVTLISRSLE--TDSAEKWYGTAYKVVDYP 515
+ A L++++ P+L+ + + P+N+R+T++ + E T+ E+WYGT Y P
Sbjct: 421 EEVLAAPYLISEWRPELIEELWNKFFPQNARITVVGQKCESVTNQEEEWYGTKYSSEAIP 480
Query: 516 ADLIKNMKSPGLNPALTLPRPNEFVSTNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDD 575
++++ P LN L LP N F+ T+F++ +D PV++ + + ++W+K+D
Sbjct: 481 KNVLEEWAKPDLNANLHLPERNPFIPTDFELVPVDAD-IQSTPVIIHNTPMIRVWFKQDV 539
Query: 576 RFWQPRGYIYLSFKLPHTHASIINSMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQ 635
F +P+ + L F P ++ +N L+ L+ QL D L + Y A A LR+ + T
Sbjct: 540 EFLKPKTLMNLDFCSPIVYSDPLNCNLTHLFVQLFKDHLNEYLYAADLAGLRLVVSNTTY 599
Query: 636 GLAITASGFNEKLIILLTRFLQGVNSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNY 695
G++++ G++ K ILL + L + +F+ + RF+ILK++ +R+LKN E PY Y
Sbjct: 600 GISVSIGGYSHKQHILLEKVLDNLYNFKIDEKRFDILKEQYVRNLKNYNAEQPYQHAVYY 659
Query: 696 YNAIINERSWSTAEKLQVFEKLTFEQLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLI 755
++ E++WS E + + L+ ++L +FI + ++ E I+GN+ E ALE+ +
Sbjct: 660 LALLLTEQAWSKQELIDAADLLSVDRLRSFIDELLSRMHVECFIYGNVNKENALEISGKV 719
Query: 756 KSLIPNNIHNLQVSNNRL----RSYLLPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSE 811
+ + N ++ R R Y L G+ +ET + + +SC + Q + +
Sbjct: 720 EDKLKNTDASVVPLLARQLMLKREYKLNNGENCLFETN--NDYHKSSCAELYLQCGMQDD 777
Query: 812 DLSALSGLFAQLIHEPCFDTLRTKEQLGYVVFSSSLNNHGTANIRILIQSEHTTPYLEWR 871
+ L Q++ EPC++ LRTKEQLGY+VF S ++G IR+++QS Y+E R
Sbjct: 778 QSNVFVDLVTQILSEPCYNQLRTKEQLGYIVFCGSRKSNGVQGIRVIVQSAKHPAYVEER 837
Query: 872 INNFYETFGQVLRDMPEEDFEKHKEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQ 931
I +F + L +M EE+F++HKEAL L+K K ++ + ++ I L Y+F Q
Sbjct: 838 IEHFLNGMIEQLENMSEEEFKRHKEALAAQKLEKPKRLSTQFGKFLTEISLQQYHFNRAQ 897
Query: 932 KKAKLVANITKQQMIDFYENYIM--SENASKLILHLKSQVEN---------KELNENELD 980
+ + +TKQQ+I++Y++YI+ + + L +H+ S E + + +
Sbjct: 898 VEVAFLQTLTKQQIIEYYKDYIILGAPSRRSLSIHVVSTAEGGAGHRDAPPEATERSTNE 957
Query: 981 TAKYPTGQLIEDVGAFKSTLFVAPVRQPMKDFE 1013
TA + D+ +FKST + P+ QP D +
Sbjct: 958 TADAKDFVKVCDLASFKSTRALYPMVQPYIDIK 990
>ref|XP_748141.1| a-pheromone processing metallopeptidase Ste23 [Aspergillus fumigatus
Af293]
gb|EAL86103.1| a-pheromone processing metallopeptidase Ste23 [Aspergillus fumigatus
Af293]
Length = 1154
Score = 1079 bits (2791), Expect = 0.0, Method: Composition-based stats.
Identities = 384/997 (38%), Positives = 575/997 (57%), Gaps = 18/997 (1%)
Query: 2 GVSLLASSSAFVTKPLLTQLVHLSPISLNFTVRRFKPFTCLSRYYTTNPYNMTSNFKTFN 61
++ A + F + +S + T + +
Sbjct: 32 SIASTAIAPHFSSSLRRRLDCPQFLLSRCWPRHTLPRSTVAPFSTAA---VTMGSIQRIT 88
Query: 62 LDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNLPGLAHFCE 121
KP+LD+RSYR I L NKL+ALL+ DP+ DKA+AS++VN+G F D ++PG+AH E
Sbjct: 89 EHLEKPELDDRSYRVIRLSNKLEALLVHDPETDKASASVNVNVGNFSDADDMPGMAHAVE 148
Query: 122 HLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGALDRFSGFFSC 181
HLLFMG++KFP EN Y+ YL+ H GSSNAYTA+ TNYFFE L+GALDRF+ FF
Sbjct: 149 HLLFMGTKKFPKENAYNQYLASHSGSSNAYTAATETNYFFE-PSSPLYGALDRFAQFFVS 207
Query: 182 PLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGTLPK 241
PLF + + D+E+ AV+SENKKNLQ+D+WR+ QL+KSL+N HPYH FSTGN++TL P+
Sbjct: 208 PLFLESTLDRELRAVDSENKKNLQSDLWRLMQLNKSLSNPAHPYHHFSTGNLKTLKEDPQ 267
Query: 242 ENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGREVPLYA-E 300
+ GL VR E +KF++ YSAN MKLC+LGRE LD L W +LF +V N +
Sbjct: 268 QRGLEVRSEFIKFYQKHYSANRMKLCVLGRESLDELEKWVEELFSEVENKDLPQNRWDDV 327
Query: 301 PIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGSGSLLAHL 360
+ E L I +PV D + L+I F D E +ES+P R +SHLIGHEG GS+LA++
Sbjct: 328 QPWRHEDLGIQIFAKPVMDTRSLDIYFPFLDEETLYESQPSRYISHLIGHEGPGSILAYI 387
Query: 361 KKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLPQKWI 420
K GWAN LSAG + G A F + I LT GL YR+V ++FQYI MLK PQ+W+
Sbjct: 388 KAKGWANGLSAGVMPICPGAAAFTISIRLTKEGLQQYREVAKVVFQYIAMLKEREPQQWV 447
Query: 421 FNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILAMGLLTKYEPDLLTQYTD 480
F+E+++++ F+FKQ S S L+ ++K P +L+ LL K++PDL+ +
Sbjct: 448 FDEMKNMAEVEFRFKQKSPASRFTSRLSSVMQKPL-PREWLLSGSLLRKFDPDLIKKALS 506
Query: 481 ALVPENSRVTLISRSLE--TDSAEKWYGTAYKVVDYPADLIKNMKSP------GLNPALT 532
L P+N R+ ++S+ DS EKWYGT YKV P D + +++ L
Sbjct: 507 YLRPDNFRLIVVSQEYPGDWDSKEKWYGTEYKVGKIPEDFMADIREALDTTPETRLSDLH 566
Query: 533 LPRPNEFVSTNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLPH 592
+P NEFV T V+K + +P P L+ DD +LW+KKDDRFW P+G ++++ + P
Sbjct: 567 MPHKNEFVPTRLSVEKKEVSEPAKTPKLIRHDDHVRLWFKKDDRFWVPKGTVHITLRNPL 626
Query: 593 THASIINSMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLIILL 652
A+ N + S LY +L DAL + YDA A L + + GL ++ G+N+K+ +LL
Sbjct: 627 AWATPANLVKSKLYCELVKDALVEYSYDAELAGLDYHLSASVFGLDVSVGGYNDKMAVLL 686
Query: 653 TRFLQGVNSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKLQ 712
+ + +RF I+K++ R +N Y+ P+ Q+ +Y + +E++W +
Sbjct: 687 EKVFTSMRDLVVNPNRFHIIKERLSRGYRNAEYQQPFYQVGDYTRYLTSEKTWINEQYAA 746
Query: 713 VFEKLTFEQLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIHNLQVSNNR 772
E + E + +F P + + E L HGN+ E+AL++ L+++++ + + R
Sbjct: 747 ELEHIEAEDISSFFPQLLSQNHIEVLAHGNLYKEDALKMTDLVENILQSRPLPQSQWHVR 806
Query: 773 LRSYLLPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSED-LSALSGLFAQLIHEPCFDT 831
R+ ++P G F YE L+D N+N CI++ + ++D L A LFAQ+ EP FD
Sbjct: 807 -RNIIIPPGSNFIYERTLRDPANINHCIEYYVYVGSITDDMLRAKLLLFAQMTDEPAFDQ 865
Query: 832 LRTKEQLGYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVLRDMPEEDF 891
LR+KEQLGYVV+S + + T R++IQSE T YLE RI+NF G+ L +M E+DF
Sbjct: 866 LRSKEQLGYVVWSGARYSATTIGYRVIIQSERTAEYLESRIDNFLIQTGETLENMSEKDF 925
Query: 892 EKHKEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMIDFYEN 951
E HK ++ N L+K KN++ E++R+ + I ++F + A V +TK ++DFY+
Sbjct: 926 EGHKRSVINKRLEKLKNLSSETSRFWSHIGSEYFDFLQNESDAANVRALTKADIVDFYKQ 985
Query: 952 YI--MSENASKLILHLKSQVENKELNENELDTAKYPT 986
I S KL ++L +Q E + ++ +
Sbjct: 986 LIDPRSPTRGKLSIYLNAQGGAHAKLEGKDQQSRLVS 1022
>gb|EDP51051.1| a-pheromone processing metallopeptidase Ste23 [Aspergillus fumigatus
A1163]
Length = 1154
Score = 1078 bits (2788), Expect = 0.0, Method: Composition-based stats.
Identities = 383/997 (38%), Positives = 575/997 (57%), Gaps = 18/997 (1%)
Query: 2 GVSLLASSSAFVTKPLLTQLVHLSPISLNFTVRRFKPFTCLSRYYTTNPYNMTSNFKTFN 61
++ A + F + +S + T + +
Sbjct: 32 SIASTAIAPHFSSSLRRRLDCPQFLLSRCWPRHTLPRSTVAPFSTAA---VTMGSIQRIT 88
Query: 62 LDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNLPGLAHFCE 121
KP+LD+RSYR I L NKL+ALL+ DP+ DKA+AS++VN+G F D ++PG+AH E
Sbjct: 89 EHLEKPELDDRSYRVIRLSNKLEALLVHDPETDKASASVNVNVGNFSDADDMPGMAHAVE 148
Query: 122 HLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGALDRFSGFFSC 181
HLLFMG++KFP EN Y+ YL+ H GSSNAYTA+ TNYFFE L+GALDRF+ FF
Sbjct: 149 HLLFMGTKKFPKENAYNQYLASHSGSSNAYTAATETNYFFE-PSSPLYGALDRFAQFFVS 207
Query: 182 PLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGTLPK 241
PLF + + D+E+ AV+SENKKNLQ+D+WR+ QL+KSL+N HPYH FSTGN++TL P+
Sbjct: 208 PLFLESTLDRELRAVDSENKKNLQSDLWRLMQLNKSLSNPAHPYHHFSTGNLKTLKEDPQ 267
Query: 242 ENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGREVPLYA-E 300
+ GL VR E +KF++ YSAN MKLC+LGRE LD L W +LF +V N +
Sbjct: 268 QRGLEVRSEFIKFYQKHYSANRMKLCVLGRESLDELEKWVEELFSEVENKDLPQNRWDDV 327
Query: 301 PIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGSGSLLAHL 360
+ E L I +PV D + ++I F D E +ES+P R +SHLIGHEG GS+LA++
Sbjct: 328 QPWRHEDLGIQIFAKPVMDTRSVDIYFPFLDEETLYESQPSRYISHLIGHEGPGSILAYI 387
Query: 361 KKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLPQKWI 420
K GWAN LSAG + G A F + I LT GL YR+V ++FQYI MLK PQ+W+
Sbjct: 388 KAKGWANGLSAGVMPICPGAAAFTISIRLTKEGLQQYREVAKVVFQYIAMLKEREPQQWV 447
Query: 421 FNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILAMGLLTKYEPDLLTQYTD 480
F+E+++++ F+FKQ S S L+ ++K P +L+ LL K++PDL+ +
Sbjct: 448 FDEMKNLAEVEFRFKQKSPASRFTSRLSSVMQKPL-PREWLLSGSLLRKFDPDLIKKALS 506
Query: 481 ALVPENSRVTLISRSLE--TDSAEKWYGTAYKVVDYPADLIKNMKSP------GLNPALT 532
L P+N R+ ++S+ DS EKWYGT YKV P D + +++ L
Sbjct: 507 YLRPDNFRLIVVSQEYPGDWDSKEKWYGTEYKVGKIPEDFMADIREALDTTPETRLSDLH 566
Query: 533 LPRPNEFVSTNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLPH 592
+P NEFV T V+K + +P P L+ DD +LW+KKDDRFW P+G ++++ + P
Sbjct: 567 MPHKNEFVPTRLSVEKKEVSEPAKTPKLIRHDDHVRLWFKKDDRFWVPKGTVHITLRNPL 626
Query: 593 THASIINSMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLIILL 652
A+ N + S LY +L DAL + YDA A L + + GL ++ G+N+K+ +LL
Sbjct: 627 AWATPANLVKSKLYCELVKDALVEYSYDAELAGLDYHLSASVFGLDVSVGGYNDKMAVLL 686
Query: 653 TRFLQGVNSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKLQ 712
+ + +RF I+K++ R +N Y+ P+ Q+ +Y + +E++W +
Sbjct: 687 EKVFTSMRDLVVNPNRFHIIKERLSRGYRNAEYQQPFYQVGDYTRYLTSEKTWINEQYAA 746
Query: 713 VFEKLTFEQLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIHNLQVSNNR 772
E + E + +F P + + E L HGN+ E+AL++ L+++++ + + R
Sbjct: 747 ELEHIEAEDISSFFPQLLSQNHIEVLAHGNLYKEDALKMTDLVENILQSRPLPQSQWHVR 806
Query: 773 LRSYLLPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSED-LSALSGLFAQLIHEPCFDT 831
R+ ++P G F YE L+D N+N CI++ + ++D L A LFAQ+ EP FD
Sbjct: 807 -RNIIIPPGSNFIYERTLRDPANINHCIEYYVYVGSITDDMLRAKLLLFAQMTDEPAFDQ 865
Query: 832 LRTKEQLGYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVLRDMPEEDF 891
LR+KEQLGYVV+S + + T R++IQSE T YLE RI+NF G+ L +M E+DF
Sbjct: 866 LRSKEQLGYVVWSGARYSATTIGYRVIIQSERTAEYLESRIDNFLIQTGETLENMSEKDF 925
Query: 892 EKHKEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMIDFYEN 951
E HK ++ N L+K KN++ E++R+ + I ++F + A V +TK ++DFY+
Sbjct: 926 EGHKRSVINKRLEKLKNLSSETSRFWSHIGSEYFDFLQNESDAANVRALTKADIVDFYKQ 985
Query: 952 YI--MSENASKLILHLKSQVENKELNENELDTAKYPT 986
I S KL ++L +Q E + ++ +
Sbjct: 986 LIDPRSPTRGKLSIYLNAQGGAHTKLEGKDQQSRLVS 1022
>ref|XP_534963.2| PREDICTED: similar to Insulin-degrading enzyme (Insulysin)
(Insulinase) (Insulin protease) [Canis familiaris]
Length = 994
Score = 1069 bits (2765), Expect = 0.0, Method: Composition-based stats.
Identities = 360/981 (36%), Positives = 561/981 (57%), Gaps = 45/981 (4%)
Query: 48 TNPYNMTSNFKTFNLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAF 107
+ K +K D+R YR +EL N +K LLI DP DK++A+LDV+IG+
Sbjct: 38 SYSKMNNPAIKRLGNHIIKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSL 97
Query: 108 EDPKNLPGLAHFCEHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQH 167
DP N+ GL+HFCEH+LF+G++K+P ENEYS +LS+H GSSNA+T+ ++TNY+F+V+H+H
Sbjct: 98 SDPPNIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEH 157
Query: 168 LFGALDRFSGFFSCPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHK 227
L GALDRF+ FF CPLF++ D+E+NAV+SE++KN+ ND WR++QL+K+ N KHP+ K
Sbjct: 158 LEGALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSK 217
Query: 228 FSTGNIETLGTLPKENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKD 287
F TGN TL T P + G++VR ELLKFH +YS+NLM +C+LGRE LD L++ LF +
Sbjct: 218 FGTGNKYTLETRPNQEGIDVRQELLKFHSTYYSSNLMAICVLGRESLDDLTNLVVKLFSE 277
Query: 288 VANNGREVPLYAEPIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHL 347
V N +P + E Q EHL+++ ++ P+KD++ L ++F +PD++++++S P L HL
Sbjct: 278 VENKNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHL 337
Query: 348 IGHEGSGSLLAHLKKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQY 407
IGHEG GSLL+ LK GW N L G ++G FF +++DLT+ GL H D+I+ +FQY
Sbjct: 338 IGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQY 397
Query: 408 IEMLKNSLPQKWIFNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILAMGLL 467
I+ L+ PQ+W+F E +D++ F+FK P S +A L Y + A LL
Sbjct: 398 IQKLRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHY-YPLEEVLTAEYLL 456
Query: 468 TKYEPDLLTQYTDALVPENSRVTLISRSLE--TDSAEKWYGTAYKVVDYPADLIKNMKSP 525
++ PDL+ D L PEN RV ++S+S E TD E+WYGT YK P ++IK
Sbjct: 457 EEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAVPDEVIKI---- 512
Query: 526 GLNPALTLPRPNEFVSTNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIY 585
++K + P L+ +SKLW+K+DD+F+ P+ +
Sbjct: 513 ------------------LSLEK----EAHPYPSLIKDTAMSKLWFKQDDKFFLPKACLN 550
Query: 586 LSFKLPHTHASIINSMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFN 645
F P + ++ ++ LY +L D+L + Y A A L T G+ ++ G+N
Sbjct: 551 FEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYN 610
Query: 646 EKLIILLTRFLQGVNSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSW 705
+K ILL + ++ + +FE + RFEI+K+ +R L N E P+ Y ++ E +W
Sbjct: 611 DKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAW 670
Query: 706 STAEKLQVFEKLTFEQLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPN---N 762
+ E + + +T +L FIP + ++ E L+HGNI + AL + +++ +
Sbjct: 671 TKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHT 730
Query: 763 IHNLQVSNNRLRSYLLPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFAQ 822
L R R LP F Y+ ++ + N I+ Q D+ S + LF Q
Sbjct: 731 KPLLPSQLVRYREVQLPDRGWFVYQQ--RNEVHNNCGIEIYYQTDMQSTSENMFLELFCQ 788
Query: 823 LIHEPCFDTLRTKEQLGYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQV 882
+I EPCF+TLRTKEQLGY+VFS +G +R +IQSE YLE R+ F T +
Sbjct: 789 IISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKS 848
Query: 883 LRDMPEEDFEKHKEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITK 942
+ DM EE F+KH +AL L K K ++ E A+Y I YNF + + +TK
Sbjct: 849 IEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTK 908
Query: 943 QQMIDFYEN--YIMSENASKLILHLKSQ------VENKELNENELDTAK---YPTGQLIE 991
+ +I FY+ + + K+ +H+ ++ V + +N+++ ++ P ++I+
Sbjct: 909 EDIIKFYKEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQ 968
Query: 992 DVGAFKSTLFVAPVRQPMKDF 1012
++ FK L + P+ +P +F
Sbjct: 969 NMTEFKRGLPLFPLVKPHINF 989
>ref|XP_681313.1| hypothetical protein AN8044.2 [Aspergillus nidulans FGSC A4]
gb|EAA59666.1| hypothetical protein AN8044.2 [Aspergillus nidulans FGSC A4]
Length = 1100
Score = 1062 bits (2747), Expect = 0.0, Method: Composition-based stats.
Identities = 385/970 (39%), Positives = 563/970 (58%), Gaps = 43/970 (4%)
Query: 52 NMTSNFKTFNLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPK 111
+ + KP LD+RSYR I+LPNKL+ALL+ DP+ DKAAA++DV++G+F DP
Sbjct: 1 MTMRSAERLTEGLEKPSLDDRSYRVIQLPNKLEALLVHDPETDKAAAAMDVHVGSFSDPA 60
Query: 112 NLPGLAHFCEHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVN------- 164
+L GLAH EH+LFMG+EK+P EN Y+ YL+ H GSSNAYTA TNYFFEV+
Sbjct: 61 DLQGLAHGLEHMLFMGTEKYPVENAYNQYLASHSGSSNAYTAGTETNYFFEVSATGATGE 120
Query: 165 ----------------------HQHLFGALDRFSGFFSCPLFNKDSTDKEINAVNSENKK 202
L+GALDRF+ FF PLF +++ D+E+ AV+SENKK
Sbjct: 121 SSGQVTPNGTTNGTSAESKSNGPSPLYGALDRFAQFFISPLFLENTLDREMQAVDSENKK 180
Query: 203 NLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGTLPKENGLNVRDELLKFHKNFYSAN 262
NLQ+D+WR+ QL+KSL+N HPY+ FSTGN++TL P++ G+ +R+E +KF++ YSAN
Sbjct: 181 NLQSDLWRLMQLNKSLSNPDHPYNHFSTGNLQTLKEEPQKRGVEIRNEFMKFYEKHYSAN 240
Query: 263 LMKLCILGREDLDTLSDWTYDLFKDVANNGREVPLYAE-PIMQPEHLQKIIQVRPVKDLK 321
MKL +LGRE LD L W +LF V+N + PI P + K I +PV D +
Sbjct: 241 RMKLVVLGRESLDELEKWVSELFAGVSNKDLPQNRWDGIPIWLPNDMCKQIFAKPVMDTR 300
Query: 322 KLEISFTVPDMEEHWESKPPRILSHLIGHEGSGSLLAHLKKLGWANELSAGGHTVSKGNA 381
++I F D E+ +ES+P R +SHLIGHEG GS+LA++K GWAN LSAG V G A
Sbjct: 301 SVDIYFPFLDEEKLYESQPSRYISHLIGHEGPGSILAYIKAKGWANGLSAGVMPVCPGAA 360
Query: 382 FFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLPQKWIFNELQDISNATFKFKQAGSPS 441
FF V + LT GL Y+ V+ +IF+YI M+K P+ WIF E+++++ FKFKQ S
Sbjct: 361 FFTVSVRLTQEGLQQYQQVVKVIFEYIAMIKEREPEAWIFEEMKNLAEVEFKFKQKSPAS 420
Query: 442 STVSSLAKCLEKDYIPVSRILAMGLLTKYEPDLLTQYTDALVPENSRVTLISRSLE--TD 499
S L+ ++K P +L+ LL K++P+ + + L +N ++ ++++ D
Sbjct: 421 RFTSRLSSVMQKPL-PREWLLSGSLLRKFDPEAIKKALSYLREDNFKLIVVAQDYPGDWD 479
Query: 500 SAEKWYGTAYKVVDYPADLIKNMKSP------GLNPALTLPRPNEFVSTNFKVDKIDGIK 553
+ EKWYGT YKV D P D + +++ L +P NEFV T V+K + +
Sbjct: 480 TKEKWYGTEYKVEDVPKDFMSGIRAALDTTPETRLKELHMPHKNEFVPTRLSVEKKEVSE 539
Query: 554 PLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLPHTHASIINSMLSTLYTQLANDA 613
P P L+ DD +LW+KKDDRFW P+ ++++ + P A+ N + S LY +L DA
Sbjct: 540 PQKTPKLIRHDDHVRLWFKKDDRFWVPKATVFVTLRNPLVWATPANLVKSKLYCELVRDA 599
Query: 614 LKDVQYDAACADLRISFNKTNQGLAITASGFNEKLIILLTRFLQGVNSFEPKKDRFEILK 673
L + YDA A L + + GL I+ G+N+K+ +LL + + E DRF I+K
Sbjct: 600 LVEYSYDAELAGLDYHLSASIFGLDISVGGYNDKMAVLLEKVFTSMRDLEINPDRFRIIK 659
Query: 674 DKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKLQVFEKLTFEQLINFIPTIYEGV 733
++ R KN Y+ PY Q+ +Y + ER W + + + E + F P I
Sbjct: 660 ERLTRSYKNAEYQQPYYQVGDYTRYLTAERGWLNEQYAAELDHIEAEDIKCFFPQILRQN 719
Query: 734 YFETLIHGNIKHEEALEVDSLIKSLIPNNIHNLQVSNNRLRSYLLPKGKTFRYETALKDS 793
+ E L HGNI E+AL + ++S++ N+ Q R+ ++P G + YE LKD
Sbjct: 720 HIEVLAHGNIYKEDALRMTDTVESIL-NSRTLPQSQWYVRRNVIIPPGSDYIYERPLKDP 778
Query: 794 QNVNSCIQHVTQLDVYSED-LSALSGLFAQLIHEPCFDTLRTKEQLGYVVFSSSLNNHGT 852
NVN CI++ + +++ L A LFAQ+ EP FD LR+KEQLGYVV+S + + T
Sbjct: 779 ANVNHCIEYYLFIGSIADEVLRAKLLLFAQMTDEPAFDQLRSKEQLGYVVWSGARYSATT 838
Query: 853 ANIRILIQSEHTTPYLEWRINNFYETFGQVLRDMPEEDFEKHKEALCNSLLQKFKNMAEE 912
R++IQSE T YLE RI++F FG+ L M E++FE HK ++ N L+K KN++ E
Sbjct: 839 IGYRVIIQSERTAQYLESRIDSFLSNFGKTLETMTEDEFEGHKRSVINKRLEKLKNLSSE 898
Query: 913 SARYTAAIYLGDYNFTHRQKKAKLVANITKQQMIDFYENYIMS--ENASKLILHLKSQVE 970
++R+ + I DY+F + A V +TK ++DFY+ I KL +HLK+Q
Sbjct: 899 TSRFWSHIGSEDYDFQQNETDAARVRALTKSDILDFYKQMIDPASPTRGKLSIHLKAQAG 958
Query: 971 NKELNENELD 980
+ E
Sbjct: 959 AHAVELKEQK 968
>ref|XP_001397499.1| hypothetical protein An16g01860 [Aspergillus niger]
emb|CAK42803.1| unnamed protein product [Aspergillus niger]
Length = 1167
Score = 1061 bits (2744), Expect = 0.0, Method: Composition-based stats.
Identities = 390/1007 (38%), Positives = 581/1007 (57%), Gaps = 28/1007 (2%)
Query: 4 SLLASSSAFV--TKPLLTQLVHLSPISLNFTVRRFKPFTCLSRYYTTNPYNMTSNFKTFN 61
+ A + F+ + T S + + SR + + +
Sbjct: 33 ASAAIAPHFIYPSPRFPTPNERCSSFPALRSSHALVSLSLPSRARFFSNTATMGSIERIA 92
Query: 62 LDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNLPGLAHFCE 121
KP+LD+RSYR I LPNKL+ALL+ DP DKA+A+++VN+G F D ++PG+AH E
Sbjct: 93 EQLEKPELDDRSYRVIRLPNKLEALLVHDPDTDKASAAVNVNVGNFSDADDMPGMAHAVE 152
Query: 122 HLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEV--------NHQHLFGALD 173
HLLFMG++K+P EN Y+ YL+ H GSSNAYTA+ TNYFFE+ L+GALD
Sbjct: 153 HLLFMGTQKYPKENAYNQYLASHSGSSNAYTAATETNYFFEIDTPAKPNYPTSPLYGALD 212
Query: 174 RFSGFFSCPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNI 233
RF+ FF PLF + + D+E+ AV+SENKKNLQ+D+WR+ QL+K+L+N HPYH FSTGN+
Sbjct: 213 RFAQFFVEPLFLESTLDRELRAVDSENKKNLQSDLWRLMQLNKTLSNPAHPYHHFSTGNL 272
Query: 234 ETLGTLPKENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGR 293
+TL P++ GL VR E +KF++ YS+N+MKL +LGR+ LD + W DLFK V N
Sbjct: 273 QTLKEEPQKRGLEVRQEFIKFYQAHYSSNIMKLVVLGRDPLDEMEQWVGDLFKHVKNQDL 332
Query: 294 EVPLYAE-PIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEG 352
+ PEHL K I +PV D++ L+I F D E +ES+P R LSHLIGHEG
Sbjct: 333 PQNRWDHAQPCLPEHLGKQIFAKPVMDMRSLDIYFPFMDEESMFESQPSRYLSHLIGHEG 392
Query: 353 SGSLLAHLKKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLK 412
GS+LA++K GWAN LSAG V G+AFF + + LT GL YR+V ++F+YI M+K
Sbjct: 393 PGSILAYIKAKGWANGLSAGVMPVCPGSAFFTISVRLTPEGLKQYREVTKVVFEYIGMIK 452
Query: 413 NSLPQKWIFNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILAMGLLTKYEP 472
PQ+WIF+E+++++ F+FKQ S S L+ ++K Y P +L+ LL K+EP
Sbjct: 453 EREPQQWIFDEMKNLAEVEFRFKQKSPASRFTSRLSSVMQKPY-PREWLLSGSLLRKFEP 511
Query: 473 DLLTQYTDALVPENSRVTLISRSLE--TDSAEKWYGTAYKVVDYPADLIKNMKSPGLNP- 529
+L+ + L P+N R+ ++++ + EKWYGT YKV D P D + +++
Sbjct: 512 ELVKKALSYLRPDNFRMVIVAQDYPGDWNCREKWYGTEYKVEDIPQDFMDSIRKAVETSP 571
Query: 530 -----ALTLPRPNEFVSTNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYI 584
L +P NEFV T V+K + +P P L+ DD +LWYKKDDRFW P+ +
Sbjct: 572 ESRLSELHMPHKNEFVPTRLSVEKKEVSEPAKTPKLIRHDDHVRLWYKKDDRFWVPKATV 631
Query: 585 YLSFKLPHTHASIINSMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGF 644
+++ + P A+ N + + Y++L DAL + YDA A L S + + GL I+ G+
Sbjct: 632 HITLRNPLVWATPANLVKAKFYSELVRDALNEYSYDAELAGLDYSLSASLFGLDISVGGY 691
Query: 645 NEKLIILLTRFLQGVNSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERS 704
N+K+ +LL + L + K DRF I+K++ R+ KN Y+ P+ Q+ +Y + ER+
Sbjct: 692 NDKMSVLLEKVLTSMRDLVVKPDRFNIIKERMTRNYKNAEYQQPFYQVGDYTRYLTAERT 751
Query: 705 WSTAEKLQVFEKLTFEQLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIH 764
W + E + E + F P I + E L HGN+ E+AL + L++S + +
Sbjct: 752 WLNEQYAAELEHIEAEDVSCFFPQILRQNHIEVLAHGNLYKEDALRMTDLVESTLQSR-T 810
Query: 765 NLQVSNNRLRSYLLPKGKTFRYETALKDSQNVNSCIQHVTQLDV-YSEDLSALSGLFAQL 823
+ R+ +LP G + YE LKD NVN CI++ + + L A LFAQ+
Sbjct: 811 LPESQWYVRRNMILPPGANYIYERTLKDPANVNHCIEYYLFIGKIDDDALRAKLLLFAQM 870
Query: 824 IHEPCFDTLRTKEQLGYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVL 883
EP FD LR+KEQLGYVV+S + + T R++IQSE PYLE RI++F FG+ L
Sbjct: 871 TDEPAFDQLRSKEQLGYVVWSGARYSATTMGYRVIIQSERNAPYLESRIDSFLTGFGKSL 930
Query: 884 RDMPEEDFEKHKEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQ 943
++M E+DFE HK ++ N L+K KN++ E+ R+ + I ++F + A V +T+
Sbjct: 931 QNMSEQDFENHKRSVVNKRLEKLKNLSSETNRFWSHIGSEYFDFVQNESDAANVRKLTQA 990
Query: 944 QMIDFYENYIMSE--NASKLILHLKSQ----VENKELNENELDTAKY 984
+I F++ ++ +KL +HLK+Q + E +
Sbjct: 991 DLIQFFQQFVDPTSATRAKLAIHLKAQAGAHAHATKPEEQKAQLVSL 1037
>ref|XP_971897.1| PREDICTED: similar to Insulin-degrading enzyme (Insulysin)
(Insulinase) (Insulin protease) [Tribolium castaneum]
Length = 977
Score = 1060 bits (2742), Expect = 0.0, Method: Composition-based stats.
Identities = 363/970 (37%), Positives = 564/970 (58%), Gaps = 13/970 (1%)
Query: 52 NMTSNFKTFNLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPK 111
N + + +K D+R YR +EL N +K LL+ DP DK+AA++DVN+G DP+
Sbjct: 3 NTPNLVLRRVENIIKSQEDKRLYRGLELANHMKVLLVSDPTTDKSAAAMDVNVGFMSDPR 62
Query: 112 NLPGLAHFCEHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGA 171
++ GLAHFCEH+LF+G++K+P+EN+Y+ YLS+HGGSSNA T +T Y+F++ L A
Sbjct: 63 DVYGLAHFCEHMLFLGTKKYPNENDYNKYLSEHGGSSNAATYPDHTIYYFDIVPDELNNA 122
Query: 172 LDRFSGFFSCPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTG 231
LDRFS FF PLF + +TD+E+NAVNSE++KN+ ND+WR QLDK L + KHPYH F TG
Sbjct: 123 LDRFSQFFIAPLFTESATDREMNAVNSEHEKNIPNDVWRKDQLDKHLADPKHPYHTFGTG 182
Query: 232 NIETLGTLPKENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANN 291
N TL TLPKE +NVRDELLKFH +YS+N+M L +LG+E LD L LF +V +
Sbjct: 183 NRHTLDTLPKEKNINVRDELLKFHDKWYSSNIMCLAVLGKESLDDLEQMVVKLFSEVKDK 242
Query: 292 GREVPLYAEPIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHE 351
P + E + EH + + P+KD++ L I F D++E+++S P +SHL+GHE
Sbjct: 243 AIAAPRWEEHPFKDEHFGTCVYMYPIKDVRNLNIVFPCRDLQEYYKSSPSHYISHLMGHE 302
Query: 352 GSGSLLAHLKKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEML 411
G GS+L+ LK GW+N L AG +G FF V +DLT+ G+ H D++ LIFQY+ ML
Sbjct: 303 GPGSILSTLKARGWSNNLVAGSRPAPRGLGFFGVTVDLTEEGIKHIDDIVELIFQYLNML 362
Query: 412 KNSLPQKWIFNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILAMGLLTKYE 471
K PQKW+ +E +DI N F+FK SP S ++ L L+ DY + M L +++
Sbjct: 363 KRQGPQKWVQDENRDIGNMLFRFKDKESPRSYIAGLVHTLQ-DYSMEDVLSCMYLFSEWR 421
Query: 472 PDLLTQYTDALVPENSRVTLISRSLET--DSAEKWYGTAYKVVDYPADLIKNMKSPGLNP 529
PD++ Q + VPE R+ ++++ E D E WYGT YKV P ++ + L+
Sbjct: 422 PDIIEQVWNDFVPEKIRIVVLAKQYENELDQVEPWYGTKYKVAKIPEKTLERWRKSELSG 481
Query: 530 ALTLPRPNEFVSTNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFK 589
LP NEF+ T+F++ ID + + PV++ ++++W+K+D+ F P+ + F
Sbjct: 482 DFKLPEKNEFIPTDFELYPID-KEVTEHPVIIQDTALTRVWFKQDETFLLPKANVMFDFV 540
Query: 590 LPHTHASIINSMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLI 649
P + +N L+ + QL DAL + Y A A L+ T GL + G++ K
Sbjct: 541 SPLAYLDPLNCNLTHMLVQLFRDALNEYAYAAELAGLKWELINTKYGLILAIGGYSNKQH 600
Query: 650 ILLTRFLQGVNSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAE 709
I L + ++ + +F+ RFEI K+ IR+LKN E PY Y A++ E SW+ E
Sbjct: 601 IFLDKVMEKLTNFKIDPKRFEICKENYIRNLKNFAAEQPYQHAVYYLAALLTEHSWTKQE 660
Query: 710 KLQVFEKLTFEQLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIHNLQVS 769
L E+LT ++L FIP I ++ E LIHGN E+AL++ +++ + + ++ +
Sbjct: 661 LLATTEQLTIDKLEAFIPQILSKMHIECLIHGNANKEKALQLVQIVEDRLLSTLNMSPLL 720
Query: 770 NNRL---RSYLLPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFAQLIHE 826
+L R L G + YE +++ + SCI+ Q + S++ + LFAQ++ E
Sbjct: 721 PRQLLLNRELKLEDGCNYVYE--VQNEVHKESCIELYYQCGLQSKENNMKLELFAQIVQE 778
Query: 827 PCFDTLRTKEQLGYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVLRDM 886
PCFD LRTKEQLGY+VFS ++G +RI++QS+ L+ RI F + L++M
Sbjct: 779 PCFDILRTKEQLGYIVFSGIRRSNGVQGLRIIVQSDKHPVRLDERIEEFLKNMLSYLKNM 838
Query: 887 PEEDFEKHKEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMI 946
EE+F +H+EAL L+K K ++ ++ + I Y+F + + +TK+ +I
Sbjct: 839 SEEEFARHREALAAQRLEKPKQLSTQTNIFWGEITSQQYHFDRANVEVAYLRTLTKEDII 898
Query: 947 DFYENYIMSEN--ASKLILHLKSQVEN--KELNENELDTAKYPTGQLIEDVGAFKSTLFV 1002
DFY++ + KL +H+ S + ++ ++ + G ++ D+ FKS+ +
Sbjct: 899 DFYKSLLEENAQFRKKLSVHVVSMADGGAGKMAASDKEYTVDSKGTVVCDITVFKSSHEM 958
Query: 1003 APVRQPMKDF 1012
P+ QP +
Sbjct: 959 HPLVQPYINI 968
>ref|XP_001661876.1| metalloprotease [Aedes aegypti]
gb|EAT36161.1| metalloprotease [Aedes aegypti]
Length = 1003
Score = 1060 bits (2741), Expect = 0.0, Method: Composition-based stats.
Identities = 351/969 (36%), Positives = 553/969 (57%), Gaps = 21/969 (2%)
Query: 62 LDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNLPGLAHFCE 121
+ K D R+YR ++L N LK LLI DP DK+AA+L V +G DP +PGLAHFCE
Sbjct: 31 DNITKSQQDSRNYRGLQLENGLKVLLISDPTTDKSAAALSVAVGHLSDPDEIPGLAHFCE 90
Query: 122 HLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGALDRFSGFFSC 181
H+LF+G++K+ +EN+Y S+LS++GGSSNA T + T Y+F+V + L ALDRFS FF
Sbjct: 91 HMLFLGTKKYVNENDYMSFLSENGGSSNAATYADTTKYYFDVVPEKLPEALDRFSQFFIA 150
Query: 182 PLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGTLPK 241
PLF + +T++EINAV+SE++KNL D+WRI Q++KSL + KHPY+KF TG+ +TL PK
Sbjct: 151 PLFTESATEREINAVHSEHEKNLSMDVWRIRQVNKSLCDPKHPYNKFGTGSKKTLLEDPK 210
Query: 242 ENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGREVPLYAEP 301
+N+R+EL+KFH +YSAN+M L + G+E LD L +F ++ N P + +
Sbjct: 211 TTNINIREELMKFHAKWYSANIMSLAVFGKESLDDLESMVVGMFSEIENKNVTSPEWKDL 270
Query: 302 IMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGSGSLLAHLK 361
+ + L +V PVKD + L I+F D+E+H+ + P SHLIGHEG+GS+L+ LK
Sbjct: 271 PYKNDQLATKTKVVPVKDSRSLTITFQTEDLEQHYRAGPEHYASHLIGHEGAGSILSELK 330
Query: 362 KLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLPQKWIF 421
GW N L G +T+ +G FF V +DLT +G H D++ +IFQYI MLK PQKWIF
Sbjct: 331 AKGWCNNLVGGYNTIGRGFGFFEVMVDLTQDGFEHVDDIVKIIFQYINMLKKEGPQKWIF 390
Query: 422 NELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILAMGLLTKYEPDLLTQYTDA 481
E D+ F+FK +P + VSS+ ++ Y + A L++++ PDL+ +
Sbjct: 391 EEYCDLCEMQFRFKDKENPLTLVSSVVHSMQ-SYPLEEVLAAPYLISEWRPDLIEDLWNK 449
Query: 482 LVPENSRVTLISRSLE--TDSAEKWYGTAYKVVDYPADLIKNMKSPGLNPALTLPRPNEF 539
P+N+R+T++ + E E+WYGT Y A ++++ LN L LP N F
Sbjct: 450 FYPQNARITVVGQKCEAKATCEEEWYGTKYSTEKIDAKVLEDWAKSDLNGNLHLPERNPF 509
Query: 540 VSTNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLPHTHASIIN 599
+ TNF + +D PV++ + + ++W+K+D F +P+ + L F P ++ +N
Sbjct: 510 IPTNFDLLAVDAD-IESIPVIIHNTPMMRVWFKQDVEFLKPKTLMNLDFCSPIVYSDPLN 568
Query: 600 SMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLIILLTRFLQGV 659
L+ L+ QL D L + Y A A LR+ T G++++ G++ K ILL + L +
Sbjct: 569 CNLTHLFVQLFKDHLNEYLYAAGLAGLRLGVANTTYGVSVSIGGYSHKQHILLEKVLDDM 628
Query: 660 NSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKLQVFEKLTF 719
+F+ + RFEILK++ IR+LKN E PY Y ++ E++WS E + E +T
Sbjct: 629 FNFKIDEKRFEILKEQYIRNLKNYQAEQPYQHAVYYLALLLTEQAWSKQELIDATELVTV 688
Query: 720 EQLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIHNLQVSNNRL----RS 775
++L FI + ++ E I+GN+ E+ALE+ S ++ + N+ R R
Sbjct: 689 DRLRTFIDELLSRMHVECFIYGNVNKEKALEMSSKVEDKLKKTDANVVPLLARQLMLKRE 748
Query: 776 YLLPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFAQLIHEPCFDTLRTK 835
Y L G+ +E + + +SC + Q + ++ + L Q++ EPC++ LRTK
Sbjct: 749 YKLNNGENCLFEMT--NEFHKSSCAELYLQCGMQNDQANVYVDLVTQILSEPCYNQLRTK 806
Query: 836 EQLGYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVLRDMPEEDFEKHK 895
EQLGY+VF S ++G IR+++QS + ++E RI +F L +M EE+F++HK
Sbjct: 807 EQLGYIVFCGSRKSNGVQGIRVIVQSANHPAFVEERIEHFLNGMVDYLENMTEEEFKRHK 866
Query: 896 EALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMIDFYENYIMS 955
EAL L+K K ++ + ++ I L Y+F Q + + +TKQQ++D+Y+ YI+
Sbjct: 867 EALAAMKLEKPKRLSSQFTKFLNEIALQQYHFNRAQVEVAFLQTLTKQQIVDYYKEYIVK 926
Query: 956 EN--ASKLILHLKSQVEN---------KELNENELDTAKYPTGQLIEDVGAFKSTLFVAP 1004
+ L +H+ S E ++ D + + D+ FKST + P
Sbjct: 927 DASLRRSLSIHVVSTAEGGAGHKDASADVAKQSTDDASTQKDFVKVGDLAGFKSTRALYP 986
Query: 1005 VRQPMKDFE 1013
+ QP D +
Sbjct: 987 MVQPYIDIK 995
>emb|CAO23586.1| unnamed protein product [Vitis vinifera]
Length = 965
Score = 1058 bits (2737), Expect = 0.0, Method: Composition-based stats.
Identities = 331/952 (34%), Positives = 509/952 (53%), Gaps = 14/952 (1%)
Query: 63 DFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNLPGLAHFCEH 122
+ +KP D R YR I L N L+ LLI DP DKAAAS+ V++G+F DP+ PGLAHF EH
Sbjct: 7 EIVKPRTDTREYRRIVLRNSLEVLLISDPDTDKAAASMSVSVGSFCDPEGFPGLAHFLEH 66
Query: 123 LLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGALDRFSGFFSCP 182
+LF SEK+P E+ YS Y+ +HGGS+NA+T+S++TNY+F+VN ALDRF+ FF P
Sbjct: 67 MLFYASEKYPLEDSYSKYIIEHGGSTNAFTSSEHTNYYFDVNSDCFEEALDRFAQFFVKP 126
Query: 183 LFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGTLPKE 242
L + D+T +EI AV+SEN+KNL +D WR+ QL K ++ HPYHKFSTGN +TL PKE
Sbjct: 127 LMSADATTREIKAVDSENQKNLLSDAWRMCQLQKHISAEGHPYHKFSTGNWDTLEVKPKE 186
Query: 243 NGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGREVPLYAEPI 302
GL+ R EL+KF++ YSANLM L + +E LD + F+++ N R
Sbjct: 187 KGLDTRHELIKFYEEHYSANLMHLVVYTKESLDKIQSLVEHKFQEIQNKDRSNFQIPGQP 246
Query: 303 MQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGSGSLLAHLKK 362
EHLQ +++ P+K KL + + + +++ P R L HLIGHEG GSL LK
Sbjct: 247 CTSEHLQILVKTVPIKQGHKLRVIWPITPSIHNYKEGPCRYLGHLIGHEGEGSLFYILKT 306
Query: 363 LGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLPQKWIFN 422
LGWA LSAG + +FF V IDLT+ G H +D++ L+F+YI +L+ + KWIF+
Sbjct: 307 LGWATSLSAGEGDWTCEFSFFKVVIDLTEAGHEHMQDIVGLLFKYISLLQQTGVCKWIFD 366
Query: 423 ELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILAMGLLTKYEPDLLTQYTDAL 482
EL I F ++ P V +++ +E Y P ++ L +K+ PD++ + D L
Sbjct: 367 ELSAICETVFHYQDKIPPIDYVVNVSSNME-LYPPKDWLVGSSLPSKFSPDVIQKVLDEL 425
Query: 483 VPENSRVTLISRSLE--TDSAEKWYGTAYKVVDYPADLIKNMKSPGLNPALTLPRPNEFV 540
P N R+ S++ E TD E WYGTAY + + +I+ N L LP PN F+
Sbjct: 426 APNNVRIFWESKNFEGHTDMVEPWYGTAYSIEKITSSMIQQWMLAAPNEHLHLPSPNVFI 485
Query: 541 STNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLPHTHASIINS 600
T+ + D + PVLL S LWYK D F P+ Y+ + F P +S
Sbjct: 486 PTDLSLK--DVQEKAKFPVLLRKSSYSTLWYKPDTMFSTPKAYVKIDFNCPFASSSPEAD 543
Query: 601 MLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLIILLTRFLQGVN 660
+L+ ++T+L D L + Y A A L N T+ G + +G+N KL ILL ++ +
Sbjct: 544 VLTDIFTRLLMDYLNEYAYYAQVAGLYYGINHTDSGFQVAVTGYNHKLRILLETVVEKIA 603
Query: 661 SFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKLQVFEKLTFE 720
+F+ K DRF ++K+ + +N ++ PY Q Y + I+ + +W + L+V L +
Sbjct: 604 NFKVKPDRFLVIKEMVTKEYQNFKFQQPYQQAMYYCSLILQDNTWPWMDGLEVIPHLEAD 663
Query: 721 QLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLI-----PNNIHNLQVSNNRLRS 775
L F+P + + + I GNI+ +EA + I+ + P + R
Sbjct: 664 DLAKFVPMLLSRAFLDCYIAGNIEPKEAESMIHHIEDIFYSGPHPISQPLFPSQYLTNRV 723
Query: 776 YLLPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFAQLIHEPCFDTLRTK 835
L +G ++ Y + + NS + H Q+ + LFA + + F LR+
Sbjct: 724 IKLDRGMSYFYPAEGLNPSDENSALVHYIQVHRDDFLPNVKLQLFALIAKQRAFHQLRSV 783
Query: 836 EQLGYVVFSSSLNNHGTANIRILIQSEHTTP-YLEWRINNFYETFGQVLRDMPEEDFEKH 894
EQLGY+ N+ G ++ +IQS P +++ R+ F + F L M E++F+ +
Sbjct: 784 EQLGYITVLMQRNDSGIRGVQFIIQSTVKGPGHIDSRVVEFLKMFESKLYAMSEDEFKSN 843
Query: 895 KEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMIDFYENYIM 954
AL + L+K KN+ EES Y IY G F R+ + + +T++++IDF+ +I
Sbjct: 844 VNALIDMKLEKHKNLREESGFYWREIYDGTLKFDRREAEVAALKKLTQKELIDFFNEHIK 903
Query: 955 --SENASKLILHLKSQVENKELNENELDTAKYPTGQLIEDVGAFKSTLFVAP 1004
+ L + + + E +E A P I+D+ F+ + +
Sbjct: 904 VGAPQKKTLSVRVYGGLHTSEY-ADEKKEANQPKQVKIDDIFKFRKSQPLYG 954
>ref|NP_181710.1| peptidase M16 family protein / insulinase family protein [Arabidopsis
thaliana]
gb|AAC02769.1| putative zinc protease [Arabidopsis thaliana]
Length = 970
Score = 1057 bits (2735), Expect = 0.0, Method: Composition-based stats.
Identities = 340/977 (34%), Positives = 522/977 (53%), Gaps = 21/977 (2%)
Query: 54 TSNFKTFNLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNL 113
SN ++ LKP D R YR I L N L+ LLI DP DK AAS+ V++G+F DP+ L
Sbjct: 5 KSNTTVGGVEILKPRTDNREYRMIVLKNLLQVLLISDPDTDKCAASMSVSVGSFSDPQGL 64
Query: 114 PGLAHFCEHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGALD 173
GLAHF EH+LF SEK+P+E+ YS Y+++HGGS+NAYTAS+ TNY F+VN ALD
Sbjct: 65 EGLAHFLEHMLFYASEKYPEEDSYSKYITEHGGSTNAYTASEETNYHFDVNADCFDEALD 124
Query: 174 RFSGFFSCPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNI 233
RF+ FF PL + D+T +EI AV+SEN+KNL +D WRI QL K L+ HPYHKFSTGN+
Sbjct: 125 RFAQFFIKPLMSADATMREIKAVDSENQKNLLSDGWRIRQLQKHLSKEDHPYHKFSTGNM 184
Query: 234 ETLGTLPKENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGR 293
+TL P+ G++ R EL+KF++ YSAN+M L + G+E LD + D +F+++ N +
Sbjct: 185 DTLHVRPQAKGVDTRSELIKFYEEHYSANIMHLVVYGKESLDKIQDLVERMFQEIQNTNK 244
Query: 294 EVPLYAEPIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGS 353
VP + +HLQ +++ P+K KL +S+ V H++ P + L HLIGHEG
Sbjct: 245 VVPRFPGQPCTADHLQILVKAIPIKQGHKLGVSWPVTPSIHHYDEAPSQYLGHLIGHEGE 304
Query: 354 GSLLAHLKKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKN 413
GSL LK LGWA LSAG + +FF V IDLTD G H ++++ L+F YI++L+
Sbjct: 305 GSLFHALKTLGWATGLSAGEGEWTLDYSFFKVSIDLTDAGHEHMQEILGLLFNYIQLLQQ 364
Query: 414 SLPQKWIFNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILAMGLLTKYEPD 473
+ +WIF+EL I F ++ P S + +A ++ Y ++ L TK+ P
Sbjct: 365 TGVCQWIFDELSAICETKFHYQDKIPPMSYIVDIASNMQ-IYPTKDWLVGSSLPTKFNPA 423
Query: 474 LLTQYTDALVPENSRVTLISRSLE--TDSAEKWYGTAYKVVDYPADLIKNMKSPGLNPAL 531
++ + D L P N R+ S+ E TD AE WY TAY + + I+ + L
Sbjct: 424 IVQKVVDELSPSNFRIFWESQKFEGQTDKAEPWYNTAYSLEKITSSTIQEWVQSAPDVHL 483
Query: 532 TLPRPNEFVSTNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLP 591
LP PN F+ T+ + D + PVLL S+LWYK D F +P+ Y+ + F P
Sbjct: 484 HLPAPNVFIPTDLSLKDADDKE--TVPVLLRKTPFSRLWYKPDTMFSKPKAYVKMDFNCP 541
Query: 592 HTHASIINSMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLIIL 651
+S ++L+ ++T+L D L + Y A A L + ++ G +T G+N KL IL
Sbjct: 542 LAVSSPDAAVLTDIFTRLLMDYLNEYAYYAQVAGLYYGVSLSDNGFELTLLGYNHKLRIL 601
Query: 652 LTRFLQGVNSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKL 711
L + + +FE K DRF ++K+ + +N + PY Q Y + I+ +++W E+L
Sbjct: 602 LETVVGKIANFEVKPDRFAVIKETVTKEYQNYKFRQPYHQAMYYCSLILQDQTWPWTEEL 661
Query: 712 QVFEKLTFEQLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIHN-----L 766
V L E + F+P + + E I GN+++ EA + I+ ++ N+
Sbjct: 662 DVLSHLEAEDVAKFVPMLLSRTFIECYIAGNVENNEAESMVKHIEDVLFNDPKPICRPLF 721
Query: 767 QVSNNRLRSYLLPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFAQLIHE 826
+ R L +G + Y + + NS + H Q+ ++ LF + +
Sbjct: 722 PSQHLTNRVVKLGEGMKYFYHQDGSNPSDENSALVHYIQVHRDDFSMNIKLQLFGLVAKQ 781
Query: 827 PCFDTLRTKEQLGYVVFSSSLNNHGTANIRILIQSEHTTP-YLEWRINNFYETFGQVLRD 885
F LRT EQLGY+ + N+ G ++ +IQS P +++ R+ + + F L +
Sbjct: 782 ATFHQLRTVEQLGYITALAQRNDSGIYGVQFIIQSSVKGPGHIDSRVESLLKNFESKLYE 841
Query: 886 MPEEDFEKHKEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQM 945
M EDF+ + AL + L+K KN+ EES Y I G F ++ + + + KQ++
Sbjct: 842 MSNEDFKSNVTALIDMKLEKHKNLKEESRFYWREIQSGTLKFNRKEAEVSALKQLQKQEL 901
Query: 946 IDFYENYIMSENASK--LILHLKSQVENKELNENELDTAKYPTGQLIEDVGAFKSTLFVA 1003
IDF++ YI A K L + + KE+ ++ + IED+ F+ + +
Sbjct: 902 IDFFDEYIKVGAARKKSLSIRVYGSQHLKEMASDKDEVPSPS--VEIEDIVGFRKSQPLH 959
Query: 1004 PVRQPMKDFEISAPPKL 1020
F PKL
Sbjct: 960 G------SFRGCGQPKL 970
>dbj|BAE98754.1| putative zinc protease [Arabidopsis thaliana]
Length = 970
Score = 1057 bits (2733), Expect = 0.0, Method: Composition-based stats.
Identities = 340/977 (34%), Positives = 521/977 (53%), Gaps = 21/977 (2%)
Query: 54 TSNFKTFNLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNL 113
SN ++ LKP D R YR I L N L+ LLI DP DK AAS+ V++G+F DP+ L
Sbjct: 5 KSNTTVGGVEILKPRTDNREYRMIVLKNLLQVLLISDPDTDKCAASMSVSVGSFSDPQGL 64
Query: 114 PGLAHFCEHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGALD 173
GLAHF EH+LF SEK+P+E+ YS Y+++HGGS+NAYTAS+ TNY F+VN ALD
Sbjct: 65 EGLAHFLEHMLFYASEKYPEEDSYSKYITEHGGSTNAYTASEETNYHFDVNADCFDEALD 124
Query: 174 RFSGFFSCPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNI 233
RF+ FF PL + D+T +EI AV+SEN+KNL +D WRI QL K L+ HPYHKFSTGN+
Sbjct: 125 RFAQFFIKPLMSADATMREIKAVDSENQKNLLSDGWRIRQLQKHLSKEDHPYHKFSTGNM 184
Query: 234 ETLGTLPKENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGR 293
+TL P+ G++ R EL+KF++ YSAN+M L + G+E LD + D +F+++ N +
Sbjct: 185 DTLHVRPQAKGVDTRSELIKFYEEHYSANIMHLVVYGKESLDKIQDLVERMFQEIQNTNK 244
Query: 294 EVPLYAEPIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGS 353
VP + +HLQ +++ P+K KL +S+ V H++ P + L HLIGHEG
Sbjct: 245 VVPRFPGQPCTADHLQILVKAIPIKQGHKLGVSWPVTPSIHHYDEAPSQYLGHLIGHEGE 304
Query: 354 GSLLAHLKKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKN 413
GSL LK LGWA LSAG + +FF V IDLTD G H ++++ L+F YI++L+
Sbjct: 305 GSLFHALKTLGWATGLSAGEGEWTLDYSFFKVSIDLTDAGHEHMQEILGLLFNYIQLLQQ 364
Query: 414 SLPQKWIFNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILAMGLLTKYEPD 473
+ +WIF+EL I F ++ P S + +A ++ Y ++ L TK+ P
Sbjct: 365 TGVCQWIFDELSAICETKFHYQDKIPPMSYIVDIASNMQ-IYPTKDWLVGSSLPTKFNPA 423
Query: 474 LLTQYTDALVPENSRVTLISRSLE--TDSAEKWYGTAYKVVDYPADLIKNMKSPGLNPAL 531
++ + D L P N R+ S+ E TD AE WY TAY + + I+ + L
Sbjct: 424 IVQKVVDELSPSNFRIFWESQKFEGQTDKAEPWYNTAYSLEKITSSTIQEWVQSAPDVHL 483
Query: 532 TLPRPNEFVSTNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLP 591
LP PN F+ T+ + D + PVLL S+LWYK D F +P+ Y+ + F P
Sbjct: 484 HLPAPNVFIPTDLSLKDADDKE--TVPVLLRKTPFSRLWYKPDTMFSKPKAYVKMDFNCP 541
Query: 592 HTHASIINSMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLIIL 651
+S ++L+ ++T+L D L + Y A A L + ++ G +T G+N KL IL
Sbjct: 542 LAVSSPDAAVLTDIFTRLLMDYLNEYAYYAQVAGLYYGVSLSDNGFELTLLGYNHKLRIL 601
Query: 652 LTRFLQGVNSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKL 711
L + + +FE K DRF ++K+ + +N + PY Q Y + I+ +++W E+L
Sbjct: 602 LETVVGKIANFEVKPDRFAVIKETVTKEYQNYKFRQPYHQAMYYCSLILQDQTWPWTEEL 661
Query: 712 QVFEKLTFEQLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIHN-----L 766
V L E + F+P + + E I GN+++ EA + I+ ++ N+
Sbjct: 662 DVLSHLEAEDVAKFVPMLLSRTFIECYIAGNVENNEAESMVKHIEDVLFNDPKPICRPLF 721
Query: 767 QVSNNRLRSYLLPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFAQLIHE 826
R L +G + Y + + NS + H Q+ ++ LF + +
Sbjct: 722 PSQRLTNRVVKLGEGMKYFYHQDGSNPSDENSALVHYIQVHRDDFSMNIKLQLFGLVAKQ 781
Query: 827 PCFDTLRTKEQLGYVVFSSSLNNHGTANIRILIQSEHTTP-YLEWRINNFYETFGQVLRD 885
F LRT EQLGY+ + N+ G ++ +IQS P +++ R+ + + F L +
Sbjct: 782 ATFHQLRTVEQLGYITALAQRNDSGIYGVQFIIQSSVKGPGHIDSRVESLLKNFESKLYE 841
Query: 886 MPEEDFEKHKEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQM 945
M EDF+ + AL + L+K KN+ EES Y I G F ++ + + + KQ++
Sbjct: 842 MSNEDFKSNVTALIDMKLEKHKNLKEESRFYWREIQSGTLKFNRKEAEVSALKQLQKQEL 901
Query: 946 IDFYENYIMSENASK--LILHLKSQVENKELNENELDTAKYPTGQLIEDVGAFKSTLFVA 1003
IDF++ YI A K L + + KE+ ++ + IED+ F+ + +
Sbjct: 902 IDFFDEYIKVGAARKKSLSIRVYGSQHLKEMASDKDEVPSPS--VEIEDIVGFRKSQPLH 959
Query: 1004 PVRQPMKDFEISAPPKL 1020
F PKL
Sbjct: 960 G------SFRGCGQPKL 970
>gb|ABH09708.1| STE23-like protein [Penicillium marneffei]
Length = 1038
Score = 1047 bits (2708), Expect = 0.0, Method: Composition-based stats.
Identities = 383/1039 (36%), Positives = 584/1039 (56%), Gaps = 71/1039 (6%)
Query: 52 NMTSNFKTFNLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPK 111
S KP+LD+RSYR I+L N+L+ALL+ DP DKA+AS +VN+G F D +
Sbjct: 1 MTMSEVTHITDRLEKPELDDRSYRVIKLGNQLEALLVHDPDTDKASASANVNVGNFSDEE 60
Query: 112 NLPGLAHFCEHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNH------ 165
+PG+AH EHLLFMG+EK+P EN Y+ YL+ H GSSNAYT + TNYFFEV
Sbjct: 61 AMPGMAHAVEHLLFMGTEKYPKENAYNQYLASHSGSSNAYTGAIETNYFFEVAATGESKS 120
Query: 166 ------------------------QHLFGALDRFSGFFSCPLFNKDSTDKEINAVNSENK 201
L+GALDRF+ FF PLF + + D+E+ AV+SENK
Sbjct: 121 PESANGEKSAVSSSTTALSKDSATSPLYGALDRFAQFFIAPLFLESTLDRELRAVDSENK 180
Query: 202 KNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGTLPKENGLNVRDELLKFHKNFYSA 261
KNLQ+D+WR+ QL+KSL+N +HPYHKFSTGN++TL P+ G+ VR + ++FHK YSA
Sbjct: 181 KNLQSDVWRLMQLNKSLSNPEHPYHKFSTGNLQTLRDDPQSRGVEVRSKFIEFHKKHYSA 240
Query: 262 NLMKLCILGREDLDTLSDWTYDLFKDVANNGREVPLYA-EPIMQPEHLQKIIQVRPVKDL 320
N MKL +LGRE LD L W +LF +V N + + + L + +PV D
Sbjct: 241 NRMKLVVLGRESLDQLESWVVELFSEVQNKNLPQNRWDDVQPLSADQLCTQVFAKPVMDS 300
Query: 321 KKLEISFTVPDMEEHWESKPPRILSHLIGHEGSGSLLAHLKKLGWANELSAGGHTVSKGN 380
+ L+I F D +E +E+ P R +SHLIGHEG GS+L+++K GWAN LSAG +V G+
Sbjct: 301 RSLDIYFPFLDEDELYETLPSRYISHLIGHEGPGSILSYIKAKGWANGLSAGAMSVGPGS 360
Query: 381 AFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLPQKWIFNELQDISNATFKFKQAGSP 440
AFF + + LT++GLTHY++++ +IFQ+I M+K P+KWI++E+Q+++ F+FKQ
Sbjct: 361 AFFTISVRLTEDGLTHYKEIVKIIFQHIAMIKERAPEKWIYDEMQNLAEVEFRFKQKSPA 420
Query: 441 SSTVSSLAKCLEKDYIPVSRILAMGLLTKYEPDLLTQYTDALVPENSRVTLISRSLE--T 498
S S L+ ++K + LL K++ DL+T+ L +N R+ ++S+
Sbjct: 421 SRFTSRLSSVMQKPLPREWLLSGNNLLRKFDADLITKALSYLRSDNFRLMIVSQHFPGDW 480
Query: 499 DSAEKWYGTAYKVVDYPADLIKNMKSP------GLNPALTLPRPNEFVSTNFKVDKIDGI 552
D+ EKWYGT YK P D + +++ L +P NEF+ T V+K +
Sbjct: 481 DAKEKWYGTDYKEEKIPQDFLTEIRNALASAPSERVSDLHMPHKNEFIPTRLSVEKKEVA 540
Query: 553 KPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLPHTHASIINSMLSTLYTQLAND 612
+P P L+ DD ++WYKKDDRFW P+ ++++ + A+ N + + LY +L D
Sbjct: 541 QPAPTPKLIRLDDHVRVWYKKDDRFWVPKATVHITLRNSLVWATPANHVKAKLYCELVRD 600
Query: 613 ALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLIILLTRFLQGVNSFEPKKDRFEIL 672
AL + YDA A L + + + GL ++ G+N+K+ +LL + + + DRF+I+
Sbjct: 601 ALVEYSYDAELAGLDYNLSASIFGLDVSVGGYNDKMSVLLEKVVTTMRDLVVLPDRFKII 660
Query: 673 KDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKLQVFEKLTFEQLINFIPTIYEG 732
K++ R +N Y+ PY Q+ + + E++W + E + + + F P +
Sbjct: 661 KERLTRAYRNAEYQQPYYQVGDMTRYLTAEKTWINEQYAAELEHIEADDVAAFFPQLLRQ 720
Query: 733 VYFETLIHGNIKHEEALEVDSLIKSLIPNNIHNLQVSNNRLRSYLLPKGKTFRYETALKD 792
+ E L HGN+ E+AL++ ++++++ + + R R+ + P G + YE LKD
Sbjct: 721 NHIEVLAHGNLYKEDALKMTDIVENIMRSRTLPQSQWHVR-RNIIFPPGSNYIYERQLKD 779
Query: 793 SQNVNSCIQHVTQLDVYSED-LSALSGLFAQLIHEPCFDTLRTKEQLGYVVFSSSLNNHG 851
QNVN+CI++ + +++ L A L AQ+ EP FD LR+KEQLGYVV+S + +
Sbjct: 780 PQNVNNCIEYYLFVGKITDEVLRAKLLLLAQMTEEPAFDQLRSKEQLGYVVWSGARYSAT 839
Query: 852 TANIRILIQSEHTTPYLEWRINNFYETFGQVLRDMPEEDFEKHKEALCNSLLQKFKNMAE 911
T R++IQSE T YLE RI+NF F + L +M EE+FE HK ++ N L+K KN+
Sbjct: 840 TIGYRVIIQSERTAQYLEGRIDNFLAQFAKTLDEMTEEEFESHKRSIINKRLEKLKNLGS 899
Query: 912 ESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMIDFYENYI--MSENASKLILHLKSQ- 968
E++R+ I +NF + A V +TK ++ F+ YI SE +K+ +HL +Q
Sbjct: 900 ETSRFWTHIGSEYFNFLQHEVDAATVRTLTKPDIVAFFRQYIDPSSETRAKISIHLNAQS 959
Query: 969 VENKELNENELDTAK-------------YPTGQL------------IEDVGAFKSTLFVA 1003
+ EL + +TA+ G + I +V FK+ L V+
Sbjct: 960 AKTDELPVDTSETAEGAESLHNQLTNVSLSNGDVTTIKTTSRQPIYITNVPQFKARLPVS 1019
Query: 1004 PVRQPMKDFEISA--PPKL 1020
P P+ D PKL
Sbjct: 1020 PGPSPVVDLSEFGDFDPKL 1038
>ref|XP_001646584.1| hypothetical protein Kpol_1055p83 [Vanderwaltozyma polyspora DSM
70294]
gb|EDO18726.1| hypothetical protein Kpol_1055p83 [Vanderwaltozyma polyspora DSM
70294]
Length = 1020
Score = 1045 bits (2704), Expect = 0.0, Method: Composition-based stats.
Identities = 664/1016 (65%), Positives = 842/1016 (82%), Gaps = 6/1016 (0%)
Query: 4 SLLASSSAFVTKPLLTQLVHLSPISLNFTVRRFKPFTCLSRYYTTNPYNMTSNFKTFNLD 63
SLL++ V + T L S+ +R F R +T +K +L+
Sbjct: 9 SLLSNIGISVKSNVPTILSR----SIPLYLRNFTKINYYKRKMSTTSDVTKKPYKIHDLN 64
Query: 64 FLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNLPGLAHFCEHL 123
F+KPDLD+RSYRFIELPNK KALLI D DK+AASLDVNIGAF+DPKNL GLAHFCEHL
Sbjct: 65 FIKPDLDDRSYRFIELPNKFKALLIHDASTDKSAASLDVNIGAFQDPKNLQGLAHFCEHL 124
Query: 124 LFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGALDRFSGFFSCPL 183
LFMGS+KFP+ENEYSSYL+KHGGSSNAYT +QNTNYFFE+NH+HL GALDRFSGFF+CPL
Sbjct: 125 LFMGSKKFPNENEYSSYLNKHGGSSNAYTGAQNTNYFFEINHEHLHGALDRFSGFFTCPL 184
Query: 184 FNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGTLPKEN 243
FN +ST KEINAV+SENKKNLQND+WR+YQLDKSL+N KHPYHKFSTGN++TL +PK+
Sbjct: 185 FNPNSTSKEINAVDSENKKNLQNDVWRMYQLDKSLSNEKHPYHKFSTGNLKTLDEMPKKE 244
Query: 244 GLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGREVPLYAEPIM 303
GL++R+ELLKF+ + YSANLMKLC+LGREDLDT+SDW Y+LF+ V NN R +P Y EPI+
Sbjct: 245 GLDIRNELLKFYSDSYSANLMKLCVLGREDLDTMSDWVYNLFEAVPNNNRPLPEYNEPIL 304
Query: 304 QPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGSGSLLAHLKKL 363
E+L+KII V+PVKDLKKLEI+F DM+ WESKP ILSHLIGHEGSGS+L+HLK L
Sbjct: 305 LEENLKKIIHVKPVKDLKKLEITFLAQDMDLFWESKPQHILSHLIGHEGSGSILSHLKTL 364
Query: 364 GWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLPQKWIFNE 423
WANELSAGGHTVSK NAFF++DIDLT+NG HY++++ ++FQYIEMLK SLPQ+ IF E
Sbjct: 365 SWANELSAGGHTVSKDNAFFSIDIDLTENGFQHYKEIVHIVFQYIEMLKISLPQERIFLE 424
Query: 424 LQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILAMGLLTKYEPDLLTQYTDALV 483
LQDI+NA+FKFKQ +PSSTVS+L+K LEK+YIPV IL+ GL KY+P+++ Y ++L
Sbjct: 425 LQDIANASFKFKQKVNPSSTVSNLSKALEKEYIPVENILSTGLFRKYDPEIMKNYVNSLS 484
Query: 484 PENSRVTLISRSLETDSAEKWYGTAYKVVDYPADLIKNMKSPGLNPALTLPRPNEFVSTN 543
P+NSR+TL +++ETDS E WYGT Y+V DYP DL +KSPGLNP L++PRPNEF++TN
Sbjct: 485 PDNSRITLAGKAVETDSKETWYGTDYRVEDYPKDLYDTIKSPGLNPNLSIPRPNEFIATN 544
Query: 544 FKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLPHTHASIINSMLS 603
F V+K D +PL EP+LL VSKLWYKKDDRFWQPRG+IY++ KLPHT AS+IN++L+
Sbjct: 545 FDVEKFDVNEPLVEPLLLKDSPVSKLWYKKDDRFWQPRGFIYITMKLPHTQASVINNLLT 604
Query: 604 TLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLIILLTRFLQGVNSFE 663
+LY QL ND+LKD+QYDAACA+L +SF+KTNQGL IT SGFN+KLI+LL RF+ GV+ ++
Sbjct: 605 SLYVQLVNDSLKDLQYDAACANLHLSFSKTNQGLDITISGFNDKLIVLLQRFIYGVSVYQ 664
Query: 664 PKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKLQVFEKLTFEQLI 723
P K RF+I K+KTI++LKN LYEVPYSQ+S Y+++INER+WS +KL + EK+T+EQ +
Sbjct: 665 PSKLRFKIFKEKTIQNLKNCLYEVPYSQISTLYSSLINERTWSVKQKLSIIEKITYEQFL 724
Query: 724 NFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIHNLQVSNNRLRSYLLPKGKT 783
F+PTIYE YF+ L+HGN ++EEA+E+DSL++SLI +I NL V N RLRSY++P G+T
Sbjct: 725 AFLPTIYEECYFDGLVHGNFRNEEAVEIDSLVQSLITTDIVNLHVKNTRLRSYVIPNGET 784
Query: 784 FRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFAQLIHEPCFDTLRTKEQLGYVVF 843
+R+E L+D++NVNSC+QHV QL YSE+LSA+SGLFAQ+++EPCFDTLRTKEQLGYVVF
Sbjct: 785 YRFEIDLEDAENVNSCVQHVVQLGGYSEELSAMSGLFAQILNEPCFDTLRTKEQLGYVVF 844
Query: 844 SSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVLRDMPEEDFEKHKEALCNSLL 903
SSSLNNHGTANIRIL+QSEH+TPYLEWRI+ FY++FG+ LR+M +++ EKHK+ALC SL+
Sbjct: 845 SSSLNNHGTANIRILVQSEHSTPYLEWRIDEFYKSFGETLRNMSDDELEKHKDALCKSLM 904
Query: 904 QKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMIDFYENYIMSENASKLIL 963
QK+KNM EE++RYTAAIYLGDYNFTHRQKKA LVA I+K Q+I F+E++ +S NA+KL++
Sbjct: 905 QKYKNMKEENSRYTAAIYLGDYNFTHRQKKANLVAQISKDQLIKFFEDHFISANAAKLVI 964
Query: 964 HLKSQVEN--KELNENELDTAKYPTGQLIEDVGAFKSTLFVAPVRQPMKDFEISAP 1017
HLKS+V++ K++NE++LD KYPTG+LI DV FKS L+ AP+RQP+K F++ P
Sbjct: 965 HLKSKVKSSDKDINEDKLDVKKYPTGKLITDVDEFKSKLYAAPIRQPLKKFDVYKP 1020
>ref|XP_001603463.1| PREDICTED: similar to metalloprotease [Nasonia vitripennis]
Length = 999
Score = 1042 bits (2694), Expect = 0.0, Method: Composition-based stats.
Identities = 373/994 (37%), Positives = 564/994 (56%), Gaps = 29/994 (2%)
Query: 39 FTCLSRYYTTNPYNMTSNFKTFNLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAA 98
+ T + + + + +K D+R YR + L NKLK LLI DP DK+AA
Sbjct: 4 SKSFKKSITKHQSKEPTRY----NNIVKSPNDKRDYRGLILHNKLKVLLISDPMTDKSAA 59
Query: 99 SLDVNIGAFEDPKNLPGLAHFCEHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTN 158
SLDVN+G DPK LPGLAHFCEH+LF+G+ K+P+ N+Y+ YLS++GG+SNA T +TN
Sbjct: 60 SLDVNVGYLSDPKELPGLAHFCEHMLFLGTTKYPEVNDYNQYLSQNGGASNAATYLDHTN 119
Query: 159 YFFEVNHQHLFGALDRFSGFFSCPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSL 218
Y+F+VN L GALDRFS FF PLF + +T+KEI AV+ E++KN+ ND WR+ QLDKS
Sbjct: 120 YYFDVNPDKLEGALDRFSQFFVSPLFTESATEKEITAVHLEHEKNIANDTWRMDQLDKSS 179
Query: 219 TNTKHPYHKFSTGNIETLGTLPKENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLS 278
+ H Y KF TG+ +TL +PK+ ++VR ELL FH +YSAN+M L +LG+E LD L
Sbjct: 180 ADPSHAYSKFGTGSKDTLEVIPKQKNIDVRQELLNFHNTWYSANIMALSVLGKESLDDLE 239
Query: 279 DWTYDLFKDVANNGREVPLYAEPIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWES 338
D+F D+ N EVP + EH + + P+KD++ L I+F +PDM+EH+ +
Sbjct: 240 KMIVDMFSDIDNKNVEVPKWPAHPFTDEHFKTKWFIVPIKDIRNLNITFPIPDMQEHFRA 299
Query: 339 KPPRILSHLIGHEGSGSLLAHLKKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYR 398
P SHL+GHEG GSLL+ LK+ GW N L +G + ++G FF+V +DLT+ G+ H
Sbjct: 300 APVHYWSHLLGHEGKGSLLSTLKEKGWCNSLVSGKRSSARGFDFFSVYVDLTEEGILHVD 359
Query: 399 DVIVLIFQYIEMLKNSLPQKWIFNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPV 458
D++ + FQYI MLKN P +WIF E DI+ F+FK+ SP S V+ + L+ DY
Sbjct: 360 DIVTMTFQYINMLKNEGPVEWIFEEYSDIAKMNFRFKEKASPRSYVNVTVQSLQ-DYPIE 418
Query: 459 SRILAMGLLTKYEPDLLTQYTDALVPENSRVTLISRSLE--TDSAEKWYGTAYKVVDYPA 516
+ A L T++ PDL+ + + LVPE RV +++++ E DS E WYGT YK P
Sbjct: 419 EVLSASRLFTQWRPDLINELNNYLVPEKIRVQVVAKAYEANADSVEPWYGTKYKKEKIPE 478
Query: 517 DLIKNMKSPGLNPALTLPRPNEFVSTNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDR 576
DLI+ + G + A LP NEF+ T F + I+ + P ++ + + W+K+DD
Sbjct: 479 DLIQRWNNAGTDEAFQLPEKNEFIPTKFDIKSIEKAE--KFPTIIEDNPFIRTWFKQDDE 536
Query: 577 FWQPRGYIYLSFKLPHTHASIINSMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQG 636
F P+ + F P T+ I+S ++ ++ QL D+L + Y A A L+ + + G
Sbjct: 537 FLLPKATMTFDFVSPLTYIDPISSNMTYMFVQLFRDSLNEYAYSADLAGLKWELSHSKYG 596
Query: 637 LAITASGFNEKLIILLTRFLQGVNSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYY 696
L++ +G++ KL++LL + L + +F RF ILK+ IR LKN E PY + Y
Sbjct: 597 LSLIIAGYDHKLVVLLNKILDRMVNFTIDDKRFAILKENYIRGLKNFEAEQPYQHAAYYL 656
Query: 697 NAIINERSWSTAEKLQVFEKLTFEQLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIK 756
A+++E+ W E L LT +++ FIP + ++ E LIHGNI EAL+ ++
Sbjct: 657 AALMSEQVWVKNELLNACSMLTADRVRQFIPLLMSKMHIECLIHGNITKAEALKTVKNVE 716
Query: 757 SLIPNNI----HNLQVSNNRLRSYLLPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSED 812
S + +++ L R LP G + YE + + + +SC Q Q + S +
Sbjct: 717 SKLISSVKDLTPLLPKQLVLYRELELPNGCHYLYE--VDNKHHKSSCTQIYYQSGMQSTE 774
Query: 813 LSALSGLFAQLIHEPCFDTLRTKEQLGYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRI 872
+ L LF Q+I EPCF+ LRTKEQLGY+VFS +G +RI++QS ++E RI
Sbjct: 775 SNMLLELFTQIISEPCFNILRTKEQLGYIVFSGIRRTNGVQGLRIIVQSNKHPQFVEERI 834
Query: 873 NNFYETFGQVLRDMPEEDFEKHKEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQK 932
+ F E+ + +M +E+F +HKE+L L+K K + +S Y I + YNF
Sbjct: 835 DAFMESMKDYITNMSDEEFNRHKESLATQRLEKPKMLTSQSGIYWNEISMQQYNFDRANV 894
Query: 933 KAKLVANITKQQMIDFYENYIM--SENASKLILHLKSQVENKELNENELDTAKYPTGQL- 989
+ + I++ Q+IDFY++ + S KL +H+ S E E+ +
Sbjct: 895 EVAYLKTISRSQIIDFYKDVVHSESPQRHKLSIHVVSTAEGGAAAEDVTSSTPSAEETKK 954
Query: 990 -----------IEDVGAFKSTLFVAPVRQPMKDF 1012
I+D+ FK++ + P+ +P +
Sbjct: 955 TLEQAEQQPARIQDILQFKTSHPLYPLVKPFNNV 988
>ref|NP_001060044.1| Os07g0570300 [Oryza sativa (japonica cultivar-group)]
dbj|BAC79700.1| putative insulin degrading enzyme [Oryza sativa Japonica Group]
dbj|BAF21958.1| Os07g0570300 [Oryza sativa (japonica cultivar-group)]
Length = 988
Score = 1042 bits (2694), Expect = 0.0, Method: Composition-based stats.
Identities = 328/954 (34%), Positives = 517/954 (54%), Gaps = 14/954 (1%)
Query: 61 NLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNLPGLAHFC 120
+++ +P D+R YR + LPN L+ LL+ DP DKAAAS++V++G F DP+ L GLAHF
Sbjct: 28 DVEITRPRNDKRGYRRVVLPNDLECLLVSDPDTDKAAASMNVSVGYFCDPEGLEGLAHFL 87
Query: 121 EHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGALDRFSGFFS 180
EH+LF SEK+P E+ YS Y+++HGGS+NA+T ++TN+FF+VNH L ALDRF+ FF
Sbjct: 88 EHMLFYASEKYPIEDSYSKYITEHGGSTNAFTTCEHTNFFFDVNHDCLNDALDRFAQFFI 147
Query: 181 CPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGTLP 240
PL + D+T +EI AV+SEN+KNL +D WR+ QL ++ HPYHKF TGN +TL P
Sbjct: 148 KPLLSADATLREIKAVDSENQKNLLSDPWRMNQLQNHISLESHPYHKFGTGNWDTLEVKP 207
Query: 241 KENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGREVPLYAE 300
KE GL+ R EL+KF+ + YSANLM+L + G+E LD L + F V N GRE +
Sbjct: 208 KEKGLDTRLELIKFYDSHYSANLMQLVVYGKESLDNLQTLVENKFCGVRNTGRERFSFPG 267
Query: 301 PIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGSGSLLAHL 360
EHLQ +++ P+K L I + + H++ P + +SHLIGHEG GSL L
Sbjct: 268 HPCSSEHLQVLVKAVPIKQGHTLRILWPITPNIRHYKEGPCKYVSHLIGHEGEGSLFYVL 327
Query: 361 KKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLPQKWI 420
KKLGWA L AG S +FF+V I LTD G H D++ L+F+YI +L+ S KWI
Sbjct: 328 KKLGWAMSLEAGEGDWSYEFSFFSVVIKLTDVGHEHMEDIVGLLFRYITLLQTSGTLKWI 387
Query: 421 FNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILAMGLLTKYEPDLLTQYTD 480
F+ELQ I F ++ G P V++++ ++ Y P ++A + +K+ PD + +
Sbjct: 388 FDELQTICETGFHYRDKGPPIHYVANISSNMQ-IYPPEDWLIASSVPSKFSPDAIQGILN 446
Query: 481 ALVPENSRVTLISRSLE--TDSAEKWYGTAYKVVDYPADLIKNMKSPGLNPALTLPRPNE 538
L P+N R+ S+ E T+ E WYGT+Y V P +I+ L +P+PN
Sbjct: 447 ELTPDNVRIFWESKKFEGQTNLTEPWYGTSYSVEAVPPSIIQKWVEKAPVEDLHMPKPNI 506
Query: 539 FVSTNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLPHTHASII 598
F+ ++ + + + P +L S++WYK D F+ P+ YI + F P + +S
Sbjct: 507 FLPSDLSLKNAE--EKASFPCMLRKTLFSRVWYKPDTMFFTPKAYIKMDFHCPLSRSSPE 564
Query: 599 NSMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLIILLTRFLQG 658
+S+L+ ++T+L D L D YDA A L + G IT G+N+K+ LL +
Sbjct: 565 SSVLTDVFTRLLMDYLNDYAYDAQVAGLYYGVRPNDTGFQITMVGYNDKMRTLLETVIGK 624
Query: 659 VNSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKLQVFEKLT 718
+ FE K DRF ++K+ + +N + PY Q Y + I+ E++W+ E+L ++
Sbjct: 625 IAEFEVKADRFSVIKETITKEYENFKFRQPYQQAFYYCSLILEEQTWAWDEELAAVSQIE 684
Query: 719 FEQLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNI-----HNLQVSNNRL 773
L F+P + + E+ GN++ V ++ ++ N +
Sbjct: 685 ASDLEKFLPHLLGKTFIESYFAGNMEPGAVKGVMQHVEDILFNAPVSLCKALPSSQHLTK 744
Query: 774 RSYLLPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFAQLIHEPCFDTLR 833
R L +G + Y + Q+ NSC+ H Q+ + + L A + +P F LR
Sbjct: 745 RIVKLERGLRYYYPALCLNHQDENSCLLHYIQIHQDDLKKNVILQLLALVAKQPAFHQLR 804
Query: 834 TKEQLGYVVFSSSLNNHGTANIRILIQSEHTTPY-LEWRINNFYETFGQVLRDMPEEDFE 892
+ EQLGY+ N+ G ++ +IQS P L+ R+ F F L MP+ +F+
Sbjct: 805 SVEQLGYITLLRQKNDSGVRGLQFIIQSTVKDPANLDARVEAFLTMFEGTLYQMPDTEFK 864
Query: 893 KHKEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMIDFYENY 952
+ AL + L+K+KN+ EESA + I G F ++ + + ++ K+++I+F+ N+
Sbjct: 865 SNVNALIDMKLEKYKNIREESAFFWGEISEGTLKFDRKEVEVAALRDLKKEELIEFFNNH 924
Query: 953 IMSENASK--LILHLKSQVENKELNENELDTAKYPTGQLIEDVGAFKSTLFVAP 1004
+ K L + + + + E + D + P I D+ F+ + +
Sbjct: 925 VKVNAPQKKILSIQVYGGLHSSEYEKIVHDEPR-PNSYQITDIFNFRRSRPLYG 977
>emb|CAO23585.1| unnamed protein product [Vitis vinifera]
Length = 965
Score = 1041 bits (2693), Expect = 0.0, Method: Composition-based stats.
Identities = 330/958 (34%), Positives = 510/958 (53%), Gaps = 14/958 (1%)
Query: 57 FKTFNLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNLPGL 116
++ +KP D R YR I L N L+ALLI DP DKAAAS+ V++G+F DP+ PGL
Sbjct: 1 MGEAAVEIVKPRTDTREYRRIVLRNSLEALLISDPDTDKAAASMSVSVGSFSDPEGFPGL 60
Query: 117 AHFCEHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGALDRFS 176
AHF EH+LF SEK+P E+ YS Y+++HGGS+NA+TAS++TNYFF+VN ALDRF+
Sbjct: 61 AHFLEHMLFYASEKYPLEDSYSKYITEHGGSTNAFTASEHTNYFFDVNTDCFEEALDRFA 120
Query: 177 GFFSCPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETL 236
FF PL + D+T +EI AV+SENKKNL +D WR+ QL K ++ HPYHKFSTGN +TL
Sbjct: 121 QFFVKPLMSADATTREIKAVDSENKKNLLSDAWRMDQLQKHVSAEGHPYHKFSTGNRDTL 180
Query: 237 GTLPKENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGREVP 296
PKE GL+ R EL+KF++ YSANLM L + +E LD + F+++ N R
Sbjct: 181 EVKPKEKGLDTRHELIKFYEEHYSANLMHLVVYTKESLDKIQSLVEHKFQEIQNKDRINF 240
Query: 297 LYAEPIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGSGSL 356
EHLQ +++ P+K KL + + + +++ P R L HLIGHEG GSL
Sbjct: 241 HICGQPCTSEHLQILVKTVPIKQGHKLIVVWPITPSIHNYKEGPCRYLGHLIGHEGKGSL 300
Query: 357 LAHLKKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLP 416
LK LGWA LSA + +FF V IDLTD G H +D++ L+F+YI +L+ +
Sbjct: 301 FYILKTLGWATSLSAWEEDWTCEFSFFEVVIDLTDAGHEHMQDIVGLLFKYISLLQQTGV 360
Query: 417 QKWIFNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILAMGLLTKYEPDLLT 476
KWIF+EL I F ++ V +++ +E Y P ++ L +K+ PD++
Sbjct: 361 CKWIFDELSAICETMFHYQDKIPSIDYVVNVSSNME-LYPPKDWLVGSSLPSKFSPDVIQ 419
Query: 477 QYTDALVPENSRVTLISRSLE--TDSAEKWYGTAYKVVDYPADLIKNMKSPGLNPALTLP 534
+ D L P N R+ S++ E TD E WYGTA+ + +I+ L LP
Sbjct: 420 KVLDELAPNNVRIFWESKNFEGHTDMVEPWYGTAFSIEKITVSMIQQWMLAAPTEHLHLP 479
Query: 535 RPNEFVSTNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLPHTH 594
PN+F+ T+ + + + PVLL S LWYK D F P+ Y+ + F P
Sbjct: 480 DPNDFIPTDLSLKNVQ--EKAKFPVLLRKSSYSTLWYKPDTMFSTPKAYVKIDFNCPFAS 537
Query: 595 ASIINSMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLIILLTR 654
+S +L+ ++T+L D L + Y A A L + T+ G + +G+N KL ILL
Sbjct: 538 SSPEADVLTDIFTRLLMDYLNEDAYYAEVAGLYYCLSNTDSGFQVAMAGYNHKLRILLET 597
Query: 655 FLQGVNSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKLQVF 714
++ + +F+ K DRF ++K+ + +N+ ++ PY Q Y + I+++ +W + L+V
Sbjct: 598 VVKKIANFKVKPDRFLVIKELVTKGYQNVKFQQPYQQAMCYRSLILHDNTWPWMDGLEVI 657
Query: 715 EKLTFEQLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLI-----PNNIHNLQVS 769
L + L F+P + + E I GNI+ +EA + I+ + P
Sbjct: 658 PHLEADDLAKFVPMLLSRAFLECYIAGNIEPKEAEAMIHHIEDIFYSGPRPICQPLFPSQ 717
Query: 770 NNRLRSYLLPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFAQLIHEPCF 829
R L +G ++ Y + + NS + H Q+ + LFA + + F
Sbjct: 718 YLTNRVIKLDRGMSYFYPAEGLNPSDENSALVHYIQVHRDDFLPNVKLQLFALIAKQQAF 777
Query: 830 DTLRTKEQLGYVVFSSSLNNHGTANIRILIQSEHTTP-YLEWRINNFYETFGQVLRDMPE 888
LR+ EQLGY+ N+ G ++ +IQS P +++ RI F + F L M E
Sbjct: 778 HQLRSVEQLGYITELMLRNDSGIHGVQFMIQSTVKGPGHIDSRIEEFLKMFEFKLYAMSE 837
Query: 889 EDFEKHKEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMIDF 948
++F+ + L + L+K+KN+ EES Y IY G F + + + +T++++IDF
Sbjct: 838 DEFKSNVNTLVDMKLEKYKNLWEESGFYWQEIYDGTLKFDRTEAEVAALKKLTQKELIDF 897
Query: 949 YENYIM--SENASKLILHLKSQVENKELNENELDTAKYPTGQLIEDVGAFKSTLFVAP 1004
+ +I + L + + + E E + + A P I+D+ F+ + +
Sbjct: 898 FNEHIKVGAPQKKTLSVRVYGCLHTSEYAEEQKE-ANQPIQVKIDDIFKFRKSQPLYG 954
>ref|NP_984913.1| AER053Cp [Ashbya gossypii ATCC 10895]
gb|AAS52737.1| AER053Cp [Ashbya gossypii ATCC 10895]
Length = 1013
Score = 1039 bits (2688), Expect = 0.0, Method: Composition-based stats.
Identities = 576/1001 (57%), Positives = 749/1001 (74%), Gaps = 6/1001 (0%)
Query: 19 TQLVHLSPISLNFTVR-RFKPFTCLSRYYTTNPYNMTSNFKTFNLDFLKPDLDERSYRFI 77
+ +H + T R P +N + S + +P LD+R YR+I
Sbjct: 15 SHFIHRHLQVQSATRRSNLSPLFYSRSM--SNNISGVSGLRELAATLEQPLLDDRKYRYI 72
Query: 78 ELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNLPGLAHFCEHLLFMGSEKFPDENEY 137
ELPN L+ LL+ D DK+AASLDVN+GAFEDP++LPGLAHFCEHLLFMGS+KFP+ENEY
Sbjct: 73 ELPNHLRVLLVHDKNTDKSAASLDVNVGAFEDPEDLPGLAHFCEHLLFMGSKKFPNENEY 132
Query: 138 SSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGALDRFSGFFSCPLFNKDSTDKEINAVN 197
+S+LSKHGG+SNAYTASQNTNY+F VNH++L+ ALDRFSGFFSCPLFN+ ST+KEI AV+
Sbjct: 133 ASFLSKHGGASNAYTASQNTNYYFHVNHENLYDALDRFSGFFSCPLFNESSTEKEIKAVD 192
Query: 198 SENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGTLPKENGLNVRDELLKFHKN 257
SENKKNLQND+WR+YQL KSLTN HPYHKFSTGN ETL ++P+ G+NVRDELLKF+
Sbjct: 193 SENKKNLQNDMWRLYQLGKSLTNPIHPYHKFSTGNFETLWSIPRSKGVNVRDELLKFYNR 252
Query: 258 FYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGREVPLYAEPIMQPEHLQKIIQVRPV 317
YSANLMKL ILGREDLDTL+ W Y+LFKDV N+G +VP Y PEHL K+I+V+PV
Sbjct: 253 SYSANLMKLVILGREDLDTLAQWAYELFKDVPNHGTKVPEYHAQAFTPEHLMKVIKVKPV 312
Query: 318 KDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGSGSLLAHLKKLGWANELSAGGHTVS 377
K+LK +EISF VPDM++HW+ KP R LSHLIGHEG+ SLLA+LK WA +LSAG TVS
Sbjct: 313 KNLKSVEISFVVPDMDKHWQVKPARYLSHLIGHEGTDSLLAYLKNNSWAIDLSAGATTVS 372
Query: 378 KGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLPQKWIFNELQDISNATFKFKQA 437
+GNA+F+V++DLTD G+ Y VI +FQYI MLK LPQ+W+F EL+DI A FKFKQ
Sbjct: 373 EGNAYFSVNVDLTDEGVVQYEAVICAVFQYINMLKEVLPQEWVFTELKDIGEAHFKFKQK 432
Query: 438 GSPSSTVSSLAKCLEKDYIPVSRILAMGLLTKYEPDLLTQYTDALVPENSRVTLISRSLE 497
G+P++TVSSL+K L+K Y+PV IL L+ +YEP L+ +Y ++L ENSRV LIS+ +E
Sbjct: 433 GNPAATVSSLSKNLQKAYLPVQVILNTSLMRQYEPGLIMEYLNSLTLENSRVMLISQKVE 492
Query: 498 TDSAEKWYGTAYKVVDYPADLIKNMKSPGLNPALTLPRPNEFVSTNFKVDKIDG-IKPLD 556
T+ +E+WYGT Y V DY D + ++S G NPAL +P PNEF++T F V K +G +KPL
Sbjct: 493 TNLSERWYGTEYSVADYTKDFVSKIRSLGANPALKIPAPNEFIATRFDVHKDEGNVKPLL 552
Query: 557 EPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLPHTHASIINSMLSTLYTQLANDALKD 616
EP LL D KLWYKKDD FW P+GYIY+S KLPHTH+SI+NSML TLY ND+LKD
Sbjct: 553 EPFLLRDDRCGKLWYKKDDMFWVPKGYIYISMKLPHTHSSIVNSMLCTLYVDHINDSLKD 612
Query: 617 VQYDAACADLRISFNKTNQGLAITASGFNEKLIILLTRFLQGVNSFEPKKDRFEILKDKT 676
+ Y+A CA L IS KTNQGL ++ SG+N+KL++LL RF +G+ +++RF +LK +
Sbjct: 613 LAYNAECAGLEISLRKTNQGLDLSLSGYNDKLLVLLARFFEGIQKLFLREERFMVLKQRL 672
Query: 677 IRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKLQVFEKLTFEQLINFIPTIYEGVYFE 736
I+ L N LY+ PY+Q+ Y+++INERSW+T EKL + E+LTF+ L NF+PTIYE +YFE
Sbjct: 673 IQKLHNHLYDTPYTQIGRLYSSLINERSWTTQEKLDITEQLTFDHLANFVPTIYEQMYFE 732
Query: 737 TLIHGNIKHEEALEVDSLIKSLIPNNIHNLQVSNNRLRSYLLPKGKTFRYETALKDSQNV 796
L+HGN HEEALEV L+ SL+PN I N + N++LRSY +P G + YETAL D +NV
Sbjct: 733 LLVHGNFSHEEALEVYDLVSSLVPNEIRNSEGRNSKLRSYFIPAGGAYHYETALADKENV 792
Query: 797 NSCIQHVTQLDVYSEDLSALSGLFAQLIHEPCFDTLRTKEQLGYVVFSSSLNNHGTANIR 856
NSCIQ V QL YSE LSA L AQ+++EPCF+TLRT+EQLGYVVFSS LN HGT N+R
Sbjct: 793 NSCIQKVIQLGAYSELLSAKGSLLAQMVNEPCFNTLRTEEQLGYVVFSSKLNTHGTVNLR 852
Query: 857 ILIQSEHTTPYLEWRINNFYETFGQVLRDMPEEDFEKHKEALCNSLLQKFKNMAEESARY 916
IL+QSE ++ YLE RI+ + FG L M +FEKHK+A+C +L QK++N+ EE+ RY
Sbjct: 853 ILVQSERSSSYLESRIDTSCQKFGSTLEMMSNAEFEKHKDAICKTLQQKYRNLGEENDRY 912
Query: 917 TAAIYLGDYNFTHRQKKAKLVANITKQQMIDFYENYIMSENASKLILHLKSQVENKELNE 976
IYLGDYNF ++++KA+LV +TK++M+DFY+ I S+ A+ L++H+++Q ++
Sbjct: 913 VTCIYLGDYNFLYKERKAQLVRQLTKKEMLDFYQQTICSKQAASLVVHMQAQAGVQDSPA 972
Query: 977 NELDTAKYPTGQLIEDVGAFKSTLFVAPVRQPMKDFEISAP 1017
+++D YPTG I DVGAFKS L++AP+R P+K FE++ P
Sbjct: 973 DKVD--GYPTGNAITDVGAFKSQLYLAPIRAPIKKFEVTTP 1011
>ref|XP_505854.1| hypothetical protein [Yarrowia lipolytica]
emb|CAG78665.1| unnamed protein product [Yarrowia lipolytica CLIB122]
Length = 1007
Score = 1039 bits (2687), Expect = 0.0, Method: Composition-based stats.
Identities = 418/1008 (41%), Positives = 609/1008 (60%), Gaps = 17/1008 (1%)
Query: 17 LLTQLVHLSPISLNFTVRRFKPFTCLSRYYTTNPYNMTSNFKTFNLDFLKPDLDERSYRF 76
L L+P + T + Y P NMT F+ KP D+R YR
Sbjct: 9 LAFSFALLTPTYITQTPDNATTPSLSPSY---PPCNMTVPFQVIESSVDKPVTDDRQYRV 65
Query: 77 IELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNLPGLAHFCEHLLFMGSEKFPDENE 136
I L N L+ALLI DP AD+A+A++DVN+G+F DP LPGLAHFCEHLLFMG+EK+P+EN+
Sbjct: 66 ITLANGLEALLIHDPDADRASAAMDVNVGSFSDPVGLPGLAHFCEHLLFMGTEKYPEEND 125
Query: 137 YSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGALDRFSGFFSCPLFNKDSTDKEINAV 196
YS+YLS+H GSSNAYTAS+ TNYFF+V H++L GA DRF+ FF PLF + D+EI AV
Sbjct: 126 YSTYLSEHSGSSNAYTASEETNYFFDVGHEYLEGAFDRFAQFFVAPLFAASAKDREIQAV 185
Query: 197 NSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGTLPKENGLNVRDELLKFHK 256
+SENKKNLQND+WR++QL++SL+N HPY++FSTGN ETL T P E G++VR+ELLKF+K
Sbjct: 186 DSENKKNLQNDMWRLFQLERSLSNPDHPYNRFSTGNYETLHTEPLEKGMDVREELLKFYK 245
Query: 257 NFYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGREVPLYAEPIMQPEHLQKIIQVRP 316
YS+N+MKL ILGRE LDTL W + V N +P Y P++ L +++ +P
Sbjct: 246 ASYSSNIMKLVILGRESLDTLQSWVVEKLSSVVNTNATLPDYGVPLLTEGELGTLVKAKP 305
Query: 317 VKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGSGSLLAHLKKLGWANELSAGGHTV 376
+ D K +E++F VPD EHWES P SHL+GHEG GS+L LK GW + S+G V
Sbjct: 306 IMDTKSIEVTFPVPDTREHWESHPGHYYSHLVGHEGPGSILFFLKNKGWVSSCSSGAVQV 365
Query: 377 SKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLPQKWIFNELQDISNATFKFKQ 436
+G F + +LTD G+ HY+DV+V IF+Y+ ML++ Q+WI++E++D++ A F+F+Q
Sbjct: 366 CRGAGVFTISCELTDAGMNHYKDVVVHIFEYLRMLRDEPVQEWIYDEMRDVALANFRFRQ 425
Query: 437 AGSPSSTVSSLAKCLEKDYIPVSRILAMGLLTKYEPDLLTQYTDALVPENSRVTLISRSL 496
+PSST S LA L+K+++P +L+ L KY P+++ + +N ++ L+ + L
Sbjct: 426 KENPSSTTSRLATVLQKNHLPRQYLLSSSLFRKYSPEVIQAFGRHFTTDNFKIFLVGQEL 485
Query: 497 ET-DSAEKWYGTAYKVVDYPADLIKNMKSPGLNPALTLPRPNEFVSTNFKVDKIDGIKPL 555
E + EKWYGT Y AD ++ +KS G NP L LP PNEF+ T+F V +P
Sbjct: 486 EGLNQTEKWYGTQYSNDKIDADWMRRVKSAGRNPDLHLPAPNEFIPTDFSVPDKRAKEPQ 545
Query: 556 DEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLPHTHASIINSMLSTLYTQLANDALK 615
P LL + D +LW+K+DD F P+ + + K P HA NS+ +TL ++ D L
Sbjct: 546 THPTLLRNTDYVRLWHKRDDTFLVPKATVRIRLKNPIGHADPFNSVKTTLLIEVVTDLLL 605
Query: 616 DVQYDAACADLRISFNKTNQGLAITASGFNEKLIILLTRFLQGVNSFEPKKDRFEILKDK 675
+ Y A A L+ + G+ I +G+N KL LL R L + +F+ + RF I+K+
Sbjct: 606 EFAYAAEIAGLKYGVLASRDGVEIDLNGYNHKLETLLERILLKIKNFDVDQSRFNIVKET 665
Query: 676 TIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKLQVFEKLTFEQLINFIPTIYEGVYF 735
+ KN Y VPY+Q++++ ++N+ +W+ EK + E+LT E +I+F+P +
Sbjct: 666 VSKTYKNFGYNVPYAQVAHHSQYLLNDHTWTVQEKREKIEQLTREDIISFVPEFLRHLQV 725
Query: 736 ETLIHGNIKHEEALEVDSLIKSLIPNNIHNLQVSNNRLRSYLLPKGKTFRYETALKDSQN 795
ETL+ GN+ E+A+ + I +++ RS+LLP F Y+ L+D N
Sbjct: 726 ETLVVGNLAKEDAVSISQTISNVLKP-APLSPSQLVNPRSFLLPDSSAFHYDVDLEDKAN 784
Query: 796 VNSCIQHVTQLDVYS-EDLSALSGLFAQLIHEPCFDTLRTKEQLGYVVFSSSLNNHGTAN 854
VNS I ++ Q+ +S AL + AQ+ EP F+ LRTKEQLGYVVFS + T
Sbjct: 785 VNSVIDYMVQVGKFSNIRTRALLEVLAQIGQEPSFNQLRTKEQLGYVVFSGIKSTRTTLL 844
Query: 855 IRILIQSEHTTPYLEWRINNFYETFGQ-VLRDMPEEDFEKHKEALCNSLLQKFKNMAEES 913
R+LIQSE T YLE RI N+ ++R+M E +F+KH A+ L+K KN++EE+
Sbjct: 845 YRVLIQSEKTCSYLESRIENYLIEILGPMIRNMSEAEFDKHVAAVVAKKLEKRKNISEEA 904
Query: 914 ARYTAAIYLGDYNFTHRQKKAKLVANITKQQMIDFYENYIMS--ENASKLILHLKSQVEN 971
+RY + I G Y+F K A+ + + K +++FY+ Y+ + SKL+++LKSQV
Sbjct: 905 SRYWSQIISGYYDFKQNFKDAEEIKTLKKADLVEFYDRYVDPASKLRSKLVINLKSQVTK 964
Query: 972 KELNENELDTAKYPTGQLIEDVGAFKSTLFVAPVRQPMKDFEISAPPK 1019
E + P I D AFK++L + P++D + PK
Sbjct: 965 DE--------GQIPNSVPIIDHAAFKNSLSMTEAPVPVEDLKNYMDPK 1004
>ref|XP_001242515.1| hypothetical protein CIMG_06411 [Coccidioides immitis RS]
gb|EAS30932.1| hypothetical protein CIMG_06411 [Coccidioides immitis RS]
Length = 1126
Score = 1035 bits (2678), Expect = 0.0, Method: Composition-based stats.
Identities = 384/988 (38%), Positives = 567/988 (57%), Gaps = 60/988 (6%)
Query: 57 FKTFNLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNLPGL 116
++ KP +D+RSYR I L NKL+ALL+ DP DKA+AS++VN+G F D ++PG+
Sbjct: 3 VESVTDSVEKPVVDDRSYRVIRLANKLEALLVHDPNTDKASASVNVNVGNFSDDDDMPGM 62
Query: 117 AHFCEHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEV------------- 163
AH EHLLFMG+EK+P EN+Y+ YL+ H G SNAYTA+ TNY+FEV
Sbjct: 63 AHAVEHLLFMGTEKYPGENDYNQYLAAHSGHSNAYTAATETNYYFEVAATSHSQPVESPQ 122
Query: 164 ---------------------------------NHQHLFGALDRFSGFFSCPLFNKDSTD 190
LFGALDRF+ FF CPLF + D
Sbjct: 123 SALPTPSENPTPLGPLVDRRSSTVEESASTTSDPESPLFGALDRFAQFFICPLFLPSTLD 182
Query: 191 KEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGTLPKENGLNVRDE 250
+E+ AV+SENKKNLQ+D WR+ QL+KSL+N KHPYH FSTGN++TL P++ GL+VR+E
Sbjct: 183 RELRAVDSENKKNLQSDPWRLLQLNKSLSNPKHPYHHFSTGNLQTLRDEPQKRGLDVREE 242
Query: 251 LLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGREVPLYA-EPIMQPEHLQ 309
++FH+ YSAN MKL +LGRE LD L W LF DV N + P PE +Q
Sbjct: 243 FIRFHEKHYSANRMKLVVLGRESLDQLERWVVQLFSDVKNKELPQNRWDDVPPFAPEDMQ 302
Query: 310 KIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGSGSLLAHLKKLGWANEL 369
K+I +PV D + L+I F D E ++S+P R +SHLIGHEG GS+LA++K GWA EL
Sbjct: 303 KMIYAKPVMDTRSLDIFFVYQDEEHMYDSQPSRYISHLIGHEGPGSILAYIKAKGWATEL 362
Query: 370 SAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLPQKWIFNELQDISN 429
SAG V G AFF + I LT++GL H+++V ++FQYI ++K + P++WIF+E++++S
Sbjct: 363 SAGAMPVCPGAAFFNISIRLTEDGLHHHQEVAKVVFQYIALIKENPPEQWIFDEMKNLSE 422
Query: 430 ATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILAMGLLTKYEPDLLTQYTDALVPENSRV 489
F+FKQ S SSL+ ++K Y P +++ LL +++P+L+T+ L +N +
Sbjct: 423 VDFRFKQKSPASRFTSSLSSVMQKPY-PREWLISCSLLRRFDPELVTRGLSYLNADNFNI 481
Query: 490 TLISRSLE--TDSAEKWYGTAYKVVDYPADLIKNMK------SPGLNPALTLPRPNEFVS 541
LIS++ D EKWYGT Y+V P +L+ ++ S G P L LP NEFV
Sbjct: 482 ELISQTYPGDWDRREKWYGTEYRVEKVPEELLSEIRAMLESPSAGKIPELHLPHKNEFVP 541
Query: 542 TNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLPHTHASIINSM 601
T V+K + KP P L+ +D+ ++W+KKDD FW P+ + ++ + P +A+ N++
Sbjct: 542 TRLDVEKKEVDKPTQTPSLIRNDERVRVWFKKDDTFWVPKASLEITLRNPLVYATPGNNV 601
Query: 602 LSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLIILLTRFLQGVNS 661
+ LY +L DAL + YDA A L + GL ++ G+N+K+ +LL + L +
Sbjct: 602 KARLYCELVRDALTEYSYDAELAGLEYDLVPSVFGLDVSIIGYNDKMAVLLEKVLHSMKD 661
Query: 662 FEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKLQVFEKLTFEQ 721
E K DRF I+K++ R +N Y++PY Q+ NY + E+++ + + E + E
Sbjct: 662 LEVKPDRFRIVKERLTRGFRNAEYQLPYYQVGNYTRFLTAEKAFINQQLAEELEHIEAED 721
Query: 722 LINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIHNLQVSNNRLRSYLLPKG 781
+ F P + + E L HGN+ E+AL++ L++S + + R+ +LP G
Sbjct: 722 VATFFPQLLRQTHIEVLAHGNLYKEDALQLTDLVESTFKSR-PLPRSQWRVRRNMILPPG 780
Query: 782 KTFRYETALKDSQNVNSCIQHVTQLDV-YSEDLSALSGLFAQLIHEPCFDTLRTKEQLGY 840
+ YE LKD N+N CI++ + L A LFAQ+ EP FD LRTKEQLGY
Sbjct: 781 SNYIYEYTLKDPANINHCIEYYLFVGSLTDPVLRAKIQLFAQMASEPAFDQLRTKEQLGY 840
Query: 841 VVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVLRDMPEEDFEKHKEALCN 900
VV+S + + T R++IQSE YLE RI+ F F L DM + FE HK ++ N
Sbjct: 841 VVWSGARYSATTLGYRVIIQSERDCDYLESRIDAFLSRFANYLNDMTDSVFEAHKRSVIN 900
Query: 901 SLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMIDFYENYIMS--ENA 958
L+K KN++ E+ RY + I Y++ + A+ V +TK ++++FY YI +
Sbjct: 901 KRLEKMKNLSSETNRYWSHIGSEYYDYLQHETDAEAVRPLTKAEIVEFYRQYIDPQSPSR 960
Query: 959 SKLILHLKSQVENKELNENELDTAKYPT 986
+KL +H+K+Q +
Sbjct: 961 AKLAVHMKAQASASPVASVGQKDVVIEG 988
>ref|XP_001820380.1| hypothetical protein [Aspergillus oryzae RIB40]
dbj|BAE58378.1| unnamed protein product [Aspergillus oryzae]
Length = 1108
Score = 1034 bits (2674), Expect = 0.0, Method: Composition-based stats.
Identities = 377/977 (38%), Positives = 560/977 (57%), Gaps = 50/977 (5%)
Query: 54 TSNFKTFNLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNL 113
++ + + KP+LD+RSYR I LPNKL+ALL+ DP DKA+A+++VN+G F D ++
Sbjct: 1 MASIERITENLDKPELDDRSYRVIRLPNKLEALLVHDPDTDKASAAVNVNVGNFSDADDM 60
Query: 114 PGLAHFCEHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNH-------- 165
PG+AH EHLLFMG+EK+P EN Y+ YL+ H GSSNAYTA+ TNYFFEV+
Sbjct: 61 PGMAHAVEHLLFMGTEKYPKENAYNQYLASHSGSSNAYTAATETNYFFEVSATSESSDGS 120
Query: 166 ----------------------------QHLFGALDRFSGFFSCPLFNKDSTDKEINAVN 197
L+GALDRF+ FF PLF + + D+E+ AV+
Sbjct: 121 SSGNSTPTNGTTPTGQTESSKSPNSSKPSPLYGALDRFAQFFVAPLFLESTLDRELRAVD 180
Query: 198 SENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGTLPKENGLNVRDELLKFHKN 257
SENKKNLQ+D+WR+ QL+KSL+N HPYH FSTGN++TL P++ GLNVRDE +KF++
Sbjct: 181 SENKKNLQSDLWRLMQLNKSLSNPAHPYHHFSTGNLQTLKEEPQKRGLNVRDEFIKFYEK 240
Query: 258 FYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGREVPLYA-EPIMQPEHLQKIIQVRP 316
YS+N MKL +LGRE LD + W DLF V N + + + K + +P
Sbjct: 241 HYSSNRMKLVVLGRETLDEMEQWVGDLFAGVKNKNLPQNRWDDVQPWLADDMCKQVFAKP 300
Query: 317 VKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGSGSLLAHLKKLGWANELSAGGHTV 376
V D + L+I F D E +ES+P R +SHLIGHEG GS+LA++K GWAN LSAG +
Sbjct: 301 VMDTRSLDIYFPFLDEEHMYESQPSRYISHLIGHEGPGSILAYVKAKGWANGLSAGVMPI 360
Query: 377 SKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLPQKWIFNELQDISNATFKFKQ 436
G+AFF V I LT GL YR+V +F+YI ++K P++WIF+E+++++ F+FKQ
Sbjct: 361 CPGSAFFTVSIRLTKEGLRQYREVAKAVFEYIALIKEREPEQWIFDEMKNLAEVEFRFKQ 420
Query: 437 AGSPSSTVSSLAKCLEKDYIPVSRILAMGLLTKYEPDLLTQYTDALVPENSRVTLISRSL 496
S S L+ ++K P +L+ LL Y+P+L+ + L +N R+ ++++
Sbjct: 421 KTPASRFTSRLSSVMQKPL-PRDWLLSGSLLRSYKPELIKKALSYLRADNFRMVVVAQDY 479
Query: 497 E--TDSAEKWYGTAYKVVDYPADLIKNMKSP------GLNPALTLPRPNEFVSTNFKVDK 548
D EKWYGT YKV D P D + ++ + L +P NEFV T V+K
Sbjct: 480 PGDWDLKEKWYGTEYKVEDVPKDFLGEIQEALKSTPETRHSDLHMPHKNEFVPTRLSVEK 539
Query: 549 IDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLPHTHASIINSMLSTLYTQ 608
+ +P P L+ DD +LW+KKDDRFW P+ ++++ + A+ N + S Y +
Sbjct: 540 KEVSEPAKTPKLIRHDDQVRLWFKKDDRFWVPKATLHVTLRNLLVWATPANLVKSKFYCE 599
Query: 609 LANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLIILLTRFLQGVNSFEPKKDR 668
L DAL + YDA A L + + + GL ++ G+N+K+ +LL + L + DR
Sbjct: 600 LVRDALVEYSYDAELAGLDYNLSASIFGLDVSVGGYNDKMAVLLEKVLTSMRDLVVNPDR 659
Query: 669 FEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKLQVFEKLTFEQLINFIPT 728
F ++K++ R KN Y+ P+ Q+ +Y + E++W + E + + F P
Sbjct: 660 FHVIKERLSRGYKNAEYQQPFYQVGDYTRYLTAEKAWLNEQYASELEHIEPNDISCFFPQ 719
Query: 729 IYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIHNLQVSNNRLRSYLLPKGKTFRYET 788
+ + E L HGN+ E+AL + ++S++ + + R R+ ++P G F YE
Sbjct: 720 LLRQNHIEVLAHGNLYKEDALRMTDSVESILQSRPLPQSQWHVR-RNVIIPPGSDFVYER 778
Query: 789 ALKDSQNVNSCIQHVTQLD-VYSEDLSALSGLFAQLIHEPCFDTLRTKEQLGYVVFSSSL 847
ALKD NVN CI++ + + + L A LFAQ+ EP FD LR+KEQLGYVV+S +
Sbjct: 779 ALKDPANVNHCIEYYLFVGNMTDDALRAKLLLFAQMTDEPAFDQLRSKEQLGYVVWSGAR 838
Query: 848 NNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVLRDMPEEDFEKHKEALCNSLLQKFK 907
+ T R++IQSE T YLE RIN F FG+ L +M +E+FE HK ++ N L+K K
Sbjct: 839 YSATTIGYRVIIQSERTAQYLESRINAFLSNFGKALEEMSDEEFEGHKRSVVNKRLEKLK 898
Query: 908 NMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMIDFYENYIMSE--NASKLILHL 965
N+ E+ R+ + ++F + A V ++K +I+FY+ YI E KL +HL
Sbjct: 899 NLGSETTRFWTHVGSEYFDFLQNESDAANVRTLSKSDLIEFYQQYIAPESTTRGKLSVHL 958
Query: 966 KSQVENKELNENELDTA 982
K+Q NE ++
Sbjct: 959 KAQAGADTTEPNEQNST 975
>gb|EEH46323.1| insulin-degrading enzyme [Paracoccidioides brasiliensis Pb18]
Length = 1374
Score = 1033 bits (2671), Expect = 0.0, Method: Composition-based stats.
Identities = 375/990 (37%), Positives = 560/990 (56%), Gaps = 63/990 (6%)
Query: 54 TSNFKTFNLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNL 113
+ + KP +D+RSYR I LPNKL+ALL+ DP DKA+AS++VN+G F D +L
Sbjct: 1 MTAVERLADVLEKPSVDDRSYRVIRLPNKLEALLVHDPDTDKASASVNVNVGNFSDDDDL 60
Query: 114 PGLAHFCEHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQH------ 167
PG+AH EH LFMG+EK+P EN Y+ YL+ H G SNAYTA+ TNY+FEV
Sbjct: 61 PGIAHAVEHALFMGTEKYPKENAYNQYLAAHSGYSNAYTAATETNYYFEVAATATSQSKS 120
Query: 168 --------------------------------------------LFGALDRFSGFFSCPL 183
L+GALDRF+ FF PL
Sbjct: 121 SPEIPPATAAFPAEVEPLTDGLSKPPFPSIADSAASSSNDLVPPLYGALDRFAQFFIAPL 180
Query: 184 FNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGTLPKEN 243
F + + D+E+ AV+SENKKNLQND WR+ QL+KSL+N KHPYH FSTGN++TL P+
Sbjct: 181 FLESTLDRELRAVDSENKKNLQNDAWRLLQLNKSLSNPKHPYHHFSTGNLKTLRDGPQSR 240
Query: 244 GLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGREVPLYA-EPI 302
G+NVRDE ++F++ YSAN MKL +LG+E LD L W +LF DV N +
Sbjct: 241 GINVRDEFIRFYETNYSANRMKLVVLGQESLDELEGWVAELFADVKNKSLPQNRWDDVQP 300
Query: 303 MQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGSGSLLAHLKK 362
E+LQKI +PV D + L++ F D ++ +ESKP + +SHLIGHEG GS+LA++K
Sbjct: 301 FTSENLQKICFAKPVMDSRSLDMLFPYQDEDDMYESKPSKYISHLIGHEGPGSILAYIKA 360
Query: 363 LGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLPQKWIFN 422
GWA LSAG + G+A F + + LT++GL HY +++ +IFQYI ++K+ P++WIF+
Sbjct: 361 KGWAYGLSAGALALCPGSALFTISVRLTEDGLKHYEEIVKVIFQYISLIKSRAPEEWIFD 420
Query: 423 ELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILAMGLLTKYEPDLLTQYTDAL 482
E+++++ FKFKQ S SSL+ ++K Y + L+ K++ + + D
Sbjct: 421 EMKNLAEVDFKFKQKSPASRFTSSLSSVMQKPYPREWLLSGPSLIRKFDEQAIRRGLDFF 480
Query: 483 VPENSRVTLISRSLE--TDSAEKWYGTAYKVVDYPADLIKNMK------SPGLNPALTLP 534
+N + L+S++ DS EKWYGT Y+V +D++ ++ S P L LP
Sbjct: 481 RADNFNIELVSQTYPGTWDSTEKWYGTEYRVEKISSDMLSQIERILQAPSNNPLPELHLP 540
Query: 535 RPNEFVSTNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLPHTH 594
NEFV T +V+K D ++P +P L+ +DD + W+KKDD F+ P+ + ++ + P +
Sbjct: 541 HKNEFVPTRLEVEKKDVLEPAKKPTLIRNDDRVRAWFKKDDTFFVPKATLEITLRNPLVY 600
Query: 595 ASIINSMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLIILLTR 654
A+ N++L+ + L D L++ YDA L S + + GL +T SG+N+K+ +LL +
Sbjct: 601 ATPGNNVLTKIACGLIRDDLQEYSYDAELGGLDYSLSASVFGLEVTVSGYNDKMAVLLEK 660
Query: 655 FLQGVNSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKLQVF 714
L + F+ K DRF+I+KD+ + N ++ PY Q+ N + E++W +
Sbjct: 661 VLHSMRDFKVKPDRFKIVKDRMTKGFSNAEFQQPYHQVGNVTRYLTAEKAWINEQLAAEL 720
Query: 715 EKLTFEQLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIHNLQVSNNRLR 774
E + E + F P + + E L HGN+ E+ L++ LI+S + R R
Sbjct: 721 EHIEAEDVAAFFPQLLRQTHIELLGHGNLYKEDVLKMADLIESTFHARPLPKSQWHMR-R 779
Query: 775 SYLLPKGKTFRYETALKDSQNVNSCIQHVTQLDV-YSEDLSALSGLFAQLIHEPCFDTLR 833
+ + P G F YE LKD NVN CI++ + L A S LF QL +EP FD LR
Sbjct: 780 NIIFPPGSNFVYEKTLKDPANVNHCIEYYLFVGSLMDPQLRAKSLLFGQLTNEPAFDQLR 839
Query: 834 TKEQLGYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVLRDMPEEDFEK 893
T+EQLGYVV+S T R++IQS+ T YLE RI+ F F + L M E+FE
Sbjct: 840 TQEQLGYVVWSGVRYAATTLGYRVIIQSDRTNQYLETRIDAFLAGFAETLDKMTGEEFEG 899
Query: 894 HKEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMIDFYENYI 953
HK +L N L+K KN+ E+ R+ + I ++F + A ++A ++K +MI++Y YI
Sbjct: 900 HKRSLINKRLEKLKNLNSETGRFWSHIGSEYFDFLQHETDATIIAELSKAEMIEYYHQYI 959
Query: 954 --MSENASKLILHLKSQVENKELNENELDT 981
S +KL +HL +Q + + ++ T
Sbjct: 960 DPSSPTRAKLSVHLVAQSQAHKAVGSDATT 989
>ref|XP_759404.1| hypothetical protein UM03257.1 [Ustilago maydis 521]
gb|EAK84184.1| hypothetical protein UM03257.1 [Ustilago maydis 521]
Length = 1292
Score = 1029 bits (2661), Expect = 0.0, Method: Composition-based stats.
Identities = 380/981 (38%), Positives = 579/981 (59%), Gaps = 20/981 (2%)
Query: 47 TTNPYNMTSNFKTFNLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGA 106
T N + + F D D+ YR + L N L+AL+IQDPK DK++A++D+ +G
Sbjct: 198 TLNGSKAAAQYAVFTKDLEVSAQDDLRYRLVRLANGLEALVIQDPKTDKSSAAMDIRVGH 257
Query: 107 FEDPKNLPGLAHFCEHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQ 166
DP+ L GLAHFCEHLLFMG++K+P ENEYS YLS H G SNAYT NTNYFF+V+
Sbjct: 258 LSDPEELQGLAHFCEHLLFMGTKKYPRENEYSEYLSNHSGGSNAYTGMDNTNYFFDVSPD 317
Query: 167 HLFGALDRFSGFFSCPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYH 226
H GALDRF+ FF PLF+ +++EI AV+SE+KKNLQ+D+WR +QLDKSL++ HPY
Sbjct: 318 HFEGALDRFAQFFLEPLFDPSCSEREIKAVDSEHKKNLQSDMWRGFQLDKSLSDPSHPYS 377
Query: 227 KFSTGNIETLGTLPKENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFK 286
F TGN +TL PK G++VRDELLKFH +YSAN+MKL +LGREDLD L+ W + F
Sbjct: 378 HFGTGNYQTLWEDPKSKGVDVRDELLKFHDQYYSANVMKLVVLGREDLDQLTSWVIEKFS 437
Query: 287 DVANNGREVPLYAEPIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSH 346
V N GRE P + + + LQK I + V+D++KL+I+F +PD H+ SKP LSH
Sbjct: 438 GVRNTGREPPQFDRSPLTTQQLQKQIFAKSVRDVRKLKIAFPIPDQGPHFRSKPGHFLSH 497
Query: 347 LIGHEGSGSLLAHLKKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQ 406
IGHEG GS+L+HLKK GW + LSAG + G FF + IDLT GL ++ V+ +F+
Sbjct: 498 FIGHEGEGSILSHLKKKGWCDRLSAGATGDANGFEFFKISIDLTQEGLDNHEKVVEAVFK 557
Query: 407 YIEMLKNSLPQKWIFNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILAMGL 466
YI +L++S ++W +E+ +S F+FK+ P+ SS A ++ Y + L
Sbjct: 558 YIHLLRSSNLEQWTHDEVAQLSELMFRFKEKIDPADYASSTATQMQMPYPREWILSGGWL 617
Query: 467 LTKYEPDLLTQYTDALVPENSRVTLISRSLE-----TDSAEKWYGTAYKVVDYPADLIKN 521
++ +L+TQ D L P+N RV +++++L +S EKWYGT Y + P L+
Sbjct: 618 TRDFDRELITQTLDHLTPQNCRVVVMAKTLPDGSTSWESKEKWYGTEYSIKPLPQQLLT- 676
Query: 522 MKSPGLNPALTLPRPNEFVSTNFK----VDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRF 577
++P L LPRPN F+ NF + + G KP P L+L ++ ++W+K DDRF
Sbjct: 677 -QTPADFEDLHLPRPNSFIPVNFDFKGPLAEAQGKKPTPRPQLVLDNESIRVWHKLDDRF 735
Query: 578 WQPRGYIYLSFKLPHTHASIINSMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGL 637
P+ ++ + P +A+ + S+ + + +L +D+L + YDA+ A L + +Q L
Sbjct: 736 GLPKANVFFVLRNPLINATPLTSIKTRMLIELISDSLVEYSYDASLAGLSYMLDSQDQSL 795
Query: 638 AITASGFNEKLIILLTRFLQGVNSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYN 697
A++ SG+N+K+ +L L+ + +F+ RFE++KD+ R +N E PY + Y
Sbjct: 796 ALSLSGYNDKIPVLARSILEKLANFQVDPRRFELVKDRVKRSYQNFAIEEPYRHATFYTT 855
Query: 698 AIINERSWSTAEKLQVFEKLTFEQLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKS 757
++ E+ W+ EKL E+L +++ F+P + + ++ E L HGN+ EEA+E+ ++ +
Sbjct: 856 YLLQEKMWTPQEKLCELEQLNVDEVQQFLPDLLQRMHLEVLAHGNLAKEEAIELSNMAWN 915
Query: 758 LIPNNIHNLQVSNNRLRSYLLPKGKTFRYETALKDSQNVNSCIQHVTQLDV-YSEDLSAL 816
I + N + RS LLP+ + + ++ NVNS I++ Q+ ++ A
Sbjct: 916 TIKSRPVN-KTELLSSRSLLLPEKSNKIWNLPVTNAANVNSAIEYYVQIGEPTDVEMRAT 974
Query: 817 SGLFAQLIHEPCFDTLRTKEQLGYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFY 876
LF+Q+ +EP FD LRTKEQLGY+VFS + G+ R+++QSE PYLE R++ F
Sbjct: 975 LSLFSQIANEPVFDQLRTKEQLGYLVFSGIRRSTGSLGWRVIVQSERDAPYLEGRVDAFL 1034
Query: 877 ETFGQVLRDMPEEDFEKHKEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKL 936
+ F L M E++FE HK ++ + L+ KN+ EES R+ + ++ G+Y+F R +
Sbjct: 1035 DQFRATLDKMTEQEFEAHKRSIIHKKLENVKNLVEESTRFWSPVFGGNYDFLARYADVEA 1094
Query: 937 VANITKQQMIDFYENYI--MSENASKLILHLKSQVEN----KELNENELDTAKYPTGQLI 990
+A TK+Q++D + YI S SKL +HL S + L+ A G +
Sbjct: 1095 IAQTTKEQVVDLFMKYIHPSSPTRSKLSVHLNSTASPALRFSTNAVDALEQAVNAQGIPV 1154
Query: 991 EDVGAFKSTLFVAPVRQPMKD 1011
AF++ P + +KD
Sbjct: 1155 PK-EAFETLRSQQPAIETVKD 1174
>gb|AAO74689.1| RE17458p [Drosophila melanogaster]
Length = 1031
Score = 1029 bits (2660), Expect = 0.0, Method: Composition-based stats.
Identities = 350/1020 (34%), Positives = 561/1020 (55%), Gaps = 17/1020 (1%)
Query: 4 SLLASSSAFVTKPLLTQLVHLSPISLNFTVRRFKPFTCLSRYYTTNPYNMTSNFKTFNLD 63
+L A + + V I + + T P +M + +
Sbjct: 11 ALTAVFGRRSSALRASISVTHRTIG-TLIKPKMTIAESSQKSATRKPDSMEPILRL--NN 67
Query: 64 FLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNLPGLAHFCEHL 123
K D R YR ++L N LK LLI DP D +AA+L V +G DP NLPGLAHFCEH+
Sbjct: 68 IEKSLQDTRDYRGLQLENGLKVLLISDPNTDVSAAALSVQVGHMSDPTNLPGLAHFCEHM 127
Query: 124 LFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGALDRFSGFFSCPL 183
LF+G+EK+P EN Y++YLS+ GGSSNA T T Y F V L GALDRF+ FF PL
Sbjct: 128 LFLGTEKYPHENGYTTYLSQSGGSSNAATYPLMTKYHFHVAPDKLDGALDRFAQFFIAPL 187
Query: 184 FNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGTLPKEN 243
F +T++EINAVNSE++KNL +D+WRI Q+D+ L H Y KF +GN TL +PK
Sbjct: 188 FTPSATEREINAVNSEHEKNLPSDLWRIKQVDRHLAKPDHAYSKFGSGNKTTLSEIPKSK 247
Query: 244 GLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGREVPLYAEPIM 303
++VRDELLKFHK +YSAN+M L ++G+E LD L + F ++ N +VP +
Sbjct: 248 NIDVRDELLKFHKQWYSANIMCLAVIGKESLDELEGMVLEKFSEIENKNVKVPGWPRHPY 307
Query: 304 QPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGSGSLLAHLKKL 363
E + +++ P+KD++ L ISFT D+ + ++S P L+HLIGHEG GS+L+ L++L
Sbjct: 308 AEERYGQKVKIVPIKDIRSLTISFTTDDLTQFYKSGPDNYLTHLIGHEGKGSILSELRRL 367
Query: 364 GWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLPQKWIFNE 423
GW N+L AG G FF + +DLT GL H D++ ++FQY+EML+ P+KWIF+E
Sbjct: 368 GWCNDLMAGHQNTQNGFGFFDIVVDLTQEGLEHVDDIVKIVFQYLEMLRKEGPKKWIFDE 427
Query: 424 LQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILAMGLLTKYEPDLLTQYTDALV 483
++ F+FK+ P + V+ ++ + ++A L ++ PDL+ D LV
Sbjct: 428 CVKLNEMRFRFKEKEQPENLVTHAVSSMQ-IFPLEEVLIAPYLSNEWRPDLIKGLLDELV 486
Query: 484 PENSRVTLISRSLE--TDSAEKWYGTAYKVVDYPADLIKNMKSPGLNPALTLPRPNEFVS 541
P SR+ ++S+S E D AE +Y T Y + D +++ ++ LN L L PN F+
Sbjct: 487 PSKSRIVIVSQSFEPDCDLAEPYYKTKYGITRVAKDTVQSWENCELNENLKLALPNSFIP 546
Query: 542 TNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLPHTHASIINSM 601
TNF + + P P ++L + ++W+K+D++F +P+ + P + +N
Sbjct: 547 TNFDISDVPADAP-KHPTIILDTPILRVWHKQDNQFNKPKACMTFDMSNPIAYLDPLNCN 605
Query: 602 LSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLIILLTRFLQGVNS 661
L+ + L D L + YDA A L++S + G+ T GF++K ++LL + L +
Sbjct: 606 LNHMMVMLLKDQLNEYLYDAELASLKLSVMGKSCGIDFTIRGFSDKQVVLLEKLLDHLFD 665
Query: 662 FEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKLQVFEKLTFEQ 721
F + RF+ILK++ +R LKN E PY Y ++ E +W+ E L E +T+++
Sbjct: 666 FSIDEKRFDILKEEYVRSLKNFKAEQPYQHSIYYLALLLTENAWANMELLDAMELVTYDR 725
Query: 722 LINFIPTIYEGVYFETLIHGNIKHEEALEVD----SLIKSLIPNNIHNLQVSNNRLRSYL 777
++NF ++ ++ E I GN+ ++A ++ + +++ + + L + R Y
Sbjct: 726 VLNFAKEFFQRLHTECFIFGNVTKQQATDIAGRVNTRLEATNASKLPILARQMLKKREYK 785
Query: 778 LPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFAQLIHEPCFDTLRTKEQ 837
L G ++ +E + + +SC Q Q ++ + + L +Q++ EPC+D LRTKEQ
Sbjct: 786 LLAGDSYLFEKE--NEFHKSSCAQLYLQCGAQTDHTNIMVNLVSQVLSEPCYDCLRTKEQ 843
Query: 838 LGYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVLRDMPEEDFEKHKEA 897
LGY+VFS +G IRI++QS Y+E RI NF +T+ QV+ DMP ++FE+HKEA
Sbjct: 844 LGYIVFSGVRKVNGANGIRIIVQSAKHPSYVEDRIENFLQTYLQVIEDMPLDEFERHKEA 903
Query: 898 LCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMIDFYENYIMSEN 957
L L+K K + ++ +++ I + Y+F + + ++ I+K +D+++ +I +
Sbjct: 904 LAVKKLEKPKTIFQQFSQFYGEIAMQTYHFEREEAEVAILRKISKADFVDYFKKFIAKDG 963
Query: 958 --ASKLILHLKSQV--ENKELNENELDTAKYPTGQLIEDVGAFKSTLFVAPVRQPMKDFE 1013
L +H+ SQ EN ++ + I D+ FKS + P+ P D +
Sbjct: 964 EERRVLSVHIVSQQTDENATSEAEPVEITNMERHKPISDIVTFKSCKELYPIALPFLDIK 1023
>ref|NP_524182.2| Insulin degrading metalloproteinase CG5517-PA [Drosophila
melanogaster]
gb|AAF51584.2| CG5517-PA [Drosophila melanogaster]
Length = 1031
Score = 1029 bits (2660), Expect = 0.0, Method: Composition-based stats.
Identities = 349/1020 (34%), Positives = 561/1020 (55%), Gaps = 17/1020 (1%)
Query: 4 SLLASSSAFVTKPLLTQLVHLSPISLNFTVRRFKPFTCLSRYYTTNPYNMTSNFKTFNLD 63
+L A + + V I + + T P +M + +
Sbjct: 11 ALTAVFGRRSSALRASISVTHRTIG-TLIKPKMTIAESSQKSATRKPDSMEPILRL--NN 67
Query: 64 FLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNLPGLAHFCEHL 123
K D R YR ++L N LK LLI DP D +AA+L V +G DP NLPGLAHFCEH+
Sbjct: 68 IEKSLQDTRDYRGLQLENGLKVLLISDPNTDVSAAALSVQVGHMSDPTNLPGLAHFCEHM 127
Query: 124 LFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGALDRFSGFFSCPL 183
LF+G+EK+P EN Y++YLS+ GGSSNA T T Y F V L GALDRF+ FF PL
Sbjct: 128 LFLGTEKYPHENGYTTYLSQSGGSSNAATYPLMTKYHFHVAPDKLDGALDRFAQFFIAPL 187
Query: 184 FNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGTLPKEN 243
F +T++EINAVNSE++KNL +D+WRI Q+++ L H Y KF +GN TL +PK
Sbjct: 188 FTPSATEREINAVNSEHEKNLPSDLWRIKQVNRHLAKPDHAYSKFGSGNKTTLSEIPKSK 247
Query: 244 GLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGREVPLYAEPIM 303
++VRDELLKFHK +YSAN+M L ++G+E LD L + F ++ N +VP +
Sbjct: 248 NIDVRDELLKFHKQWYSANIMCLAVIGKESLDELEGMVLEKFSEIENKNVKVPGWPRHPY 307
Query: 304 QPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGSGSLLAHLKKL 363
E + +++ P+KD++ L ISFT D+ + ++S P L+HLIGHEG GS+L+ L++L
Sbjct: 308 AEERYGQKVKIVPIKDIRSLTISFTTDDLTQFYKSGPDNYLTHLIGHEGKGSILSELRRL 367
Query: 364 GWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLPQKWIFNE 423
GW N+L AG G FF + +DLT GL H D++ ++FQY+EML+ P+KWIF+E
Sbjct: 368 GWCNDLMAGHQNTQNGFGFFDIVVDLTQEGLEHVDDIVKIVFQYLEMLRKEGPKKWIFDE 427
Query: 424 LQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILAMGLLTKYEPDLLTQYTDALV 483
++ F+FK+ P + V+ ++ + ++A L ++ PDL+ D LV
Sbjct: 428 CVKLNEMRFRFKEKEQPENLVTHAVSSMQ-IFPLEEVLIAPYLSNEWRPDLIKGLLDELV 486
Query: 484 PENSRVTLISRSLE--TDSAEKWYGTAYKVVDYPADLIKNMKSPGLNPALTLPRPNEFVS 541
P SR+ ++S+S E D AE +Y T Y + D +++ ++ LN L L PN F+
Sbjct: 487 PSKSRIVIVSQSFEPDCDLAEPYYKTKYGITRVAKDTVQSWENCELNENLKLALPNSFIP 546
Query: 542 TNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLPHTHASIINSM 601
TNF + + P P ++L + ++W+K+D++F +P+ + P + +N
Sbjct: 547 TNFDISDVPADAP-KHPTIILDTPILRVWHKQDNQFNKPKACMTFDMSNPIAYLDPLNCN 605
Query: 602 LSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLIILLTRFLQGVNS 661
L+ + L D L + YDA A L++S + G+ T GF++K ++LL + L +
Sbjct: 606 LNHMMVMLLKDQLNEYLYDAELASLKLSVMGKSCGIDFTIRGFSDKQVVLLEKLLDHLFD 665
Query: 662 FEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKLQVFEKLTFEQ 721
F + RF+ILK++ +R LKN E PY Y ++ E +W+ E L E +T+++
Sbjct: 666 FSIDEKRFDILKEEYVRSLKNFKAEQPYQHSIYYLALLLTENAWANMELLDAMELVTYDR 725
Query: 722 LINFIPTIYEGVYFETLIHGNIKHEEALEVD----SLIKSLIPNNIHNLQVSNNRLRSYL 777
++NF ++ ++ E I GN+ ++A ++ + +++ + + L + R Y
Sbjct: 726 VLNFAKEFFQRLHTECFIFGNVTKQQATDIAGRVNTRLEATNASKLPILARQMLKKREYK 785
Query: 778 LPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFAQLIHEPCFDTLRTKEQ 837
L G ++ +E + + +SC Q Q ++ + + L +Q++ EPC+D LRTKEQ
Sbjct: 786 LLAGDSYLFEKE--NEFHKSSCAQLYLQCGAQTDHTNIMVNLVSQVLSEPCYDCLRTKEQ 843
Query: 838 LGYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVLRDMPEEDFEKHKEA 897
LGY+VFS +G IRI++QS Y+E RI NF +T+ QV+ DMP ++FE+HKEA
Sbjct: 844 LGYIVFSGVRKVNGANGIRIIVQSAKHPSYVEDRIENFLQTYLQVIEDMPLDEFERHKEA 903
Query: 898 LCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMIDFYENYIMSEN 957
L L+K K + ++ +++ I + Y+F + + ++ I+K +D+++ +I +
Sbjct: 904 LAVKKLEKPKTIFQQFSQFYGEIAMQTYHFEREEAEVAILRKISKADFVDYFKKFIAKDG 963
Query: 958 --ASKLILHLKSQV--ENKELNENELDTAKYPTGQLIEDVGAFKSTLFVAPVRQPMKDFE 1013
L +H+ SQ EN ++ + I D+ FKS + P+ P D +
Sbjct: 964 EERRVLSVHIVSQQTDENATSEAEPVEITNMERHKPISDIVTFKSCKELYPIALPFLDIK 1023
>ref|XP_001543275.1| conserved hypothetical protein [Ajellomyces capsulatus NAm1]
gb|EDN02457.1| conserved hypothetical protein [Ajellomyces capsulatus NAm1]
Length = 1158
Score = 1026 bits (2654), Expect = 0.0, Method: Composition-based stats.
Identities = 378/997 (37%), Positives = 552/997 (55%), Gaps = 65/997 (6%)
Query: 54 TSNFKTFNLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNL 113
+ + D KP +D+RSYR I LPNKL+ALL+ DP DKA+AS++VN+G F D +L
Sbjct: 1 MAIVERLTEDLEKPSVDDRSYRVIRLPNKLEALLVHDPDTDKASASVNVNVGNFSDDDDL 60
Query: 114 PGLAHFCEHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQH------ 167
PG+AH EH LFMG++K+P EN Y+ YL+ H G SNAYT + TNYFFEV
Sbjct: 61 PGIAHAVEHALFMGTKKYPKENAYNQYLAAHSGHSNAYTGATETNYFFEVAATATSVSKS 120
Query: 168 ----------------------------------------------LFGALDRFSGFFSC 181
L+GALDRF+ FF
Sbjct: 121 TQSSTPATPIPAEVEPLTDGLSRPTIPLTATAADSAVSSSSDLVPPLYGALDRFAQFFIA 180
Query: 182 PLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGTLPK 241
PLF + + D+E+ AV+SENKKNLQND WR+ QL+KSL+N KHPYH FSTGN++TL P+
Sbjct: 181 PLFLEATLDRELRAVDSENKKNLQNDDWRLMQLNKSLSNPKHPYHHFSTGNLQTLRDGPQ 240
Query: 242 ENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGREVPLYA-E 300
G+NVRDE ++F++ YSAN MKL +LGRE LD L W +LF DV N +
Sbjct: 241 SRGVNVRDEFIRFYETNYSANRMKLVVLGRESLDELEGWVAELFADVKNKNLPQNRWDDV 300
Query: 301 PIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGSGSLLAHL 360
P LQKI +PV D + L+I FT D E ++SKP R +SHLIGHEG GS+LAH+
Sbjct: 301 QPYTPADLQKICFAKPVMDTRSLDIFFTYQDEENLYDSKPARYISHLIGHEGPGSILAHI 360
Query: 361 KKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLPQKWI 420
K GWA LSAG + G+AFF + I LT++G+ +Y++VI IFQYI +LK+ +P++WI
Sbjct: 361 KAKGWAYGLSAGPIPICPGSAFFTISIRLTEDGVNNYQEVIKTIFQYISILKSRVPEEWI 420
Query: 421 FNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILAMGLLTKYEPDLLTQYTD 480
F E++ ++ FKF+Q S SSL+ ++K + + LL K++ + + D
Sbjct: 421 FEEMKTLAEVDFKFRQKSPASGFTSSLSSVMQKPFPREWLLSGPYLLRKFDGQAIQRALD 480
Query: 481 ALVPENSRVTLISRSLE--TDSAEKWYGTAYKVVDYPADLIKNM------KSPGLNPALT 532
++ + L+S++ DS EKWYGT Y+V P DL+ + S P L
Sbjct: 481 CFRIDSFNIELVSQTYPGNWDSKEKWYGTEYRVEKLPTDLLSEIGRILEAPSYNPMPELH 540
Query: 533 LPRPNEFVSTNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLPH 592
LP NEF+ T F V+K + +P P L+ +DD + W+KKDD F+ P+ + + + P
Sbjct: 541 LPHKNEFLPTRFDVEKKEVAQPAKRPTLIRNDDRVRAWFKKDDTFYVPKASVEIILRNPL 600
Query: 593 THASIINSMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLIILL 652
+A+ N++L+ L L D L++ YDA L S + + GL ++ SG+N+K+ +LL
Sbjct: 601 AYATPGNNVLTKLACGLIRDDLQEYSYDAELGGLDYSLSPSVFGLEVSVSGYNDKMAVLL 660
Query: 653 TRFLQGVNSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKLQ 712
+ L + F K DRF+I+K + N Y+ PY Q+ N + E++W T +
Sbjct: 661 EKVLHSMRDFRVKPDRFKIVKQRMADGFSNSEYQQPYHQVGNVTRYLTAEKTWITEQLAA 720
Query: 713 VFEKLTFEQLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNNIHNLQVSNNR 772
E + + F P + + E L HGN+ E+ L++ ++++S + + N
Sbjct: 721 ELEHIEPGDVAAFFPQLLRQTHIELLGHGNLYREDVLKMGNMVESAF-HARPLPRSQWNV 779
Query: 773 LRSYLLPKGKTFRYETALKDSQNVNSCIQHVTQLDV-YSEDLSALSGLFAQLIHEPCFDT 831
R+ ++P G + YE LKD N+N CI++ + L A LF QL +EP FD
Sbjct: 780 RRNIIIPPGSNYIYEKTLKDPANINHCIEYYLFVGDITDPQLRAKLLLFGQLTNEPAFDQ 839
Query: 832 LRTKEQLGYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYETFGQVLRDMPEEDF 891
LRT+EQLGYVV+S T R++IQSE YLE RI+ F F + L M +E+F
Sbjct: 840 LRTQEQLGYVVWSGIRYGATTLGYRVIIQSEKPNQYLESRIDAFLIRFARALDSMTDEEF 899
Query: 892 EKHKEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMIDFYEN 951
E HK +L N L+K KN+ E +R+ + I ++FT + A+ VA +TK +++FY+
Sbjct: 900 EDHKRSLINKRLEKLKNLNSEMSRFWSHITSEYFDFTQHETDAEKVAGLTKDDIVEFYQQ 959
Query: 952 YIMS--ENASKLILHLKSQVENKELNENELDTAKYPT 986
YI +KL +HL +Q + + K
Sbjct: 960 YIDPQSRTRAKLSVHLNAQSSATDDERKKKVVEKLSN 996
>emb|CAC67408.1| insulin degrading enzyme [Solanum lycopersicum]
Length = 971
Score = 1024 bits (2648), Expect = 0.0, Method: Composition-based stats.
Identities = 329/956 (34%), Positives = 515/956 (53%), Gaps = 14/956 (1%)
Query: 58 KTFNLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNLPGLA 117
+ ++ +KP +D+R YR I L N L+ LLI DP+ DK AAS++V +GAF DP+ L GLA
Sbjct: 8 ENMAVEIVKPRIDKRDYRRIVLQNNLEILLISDPETDKCAASMNVCVGAFSDPEGLEGLA 67
Query: 118 HFCEHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGALDRFSG 177
HF EH+LF SEK+P E+ YS Y++++GGS+NA+T+S++TNY+FEVN ALDRF+
Sbjct: 68 HFLEHMLFYASEKYPVEDSYSKYITENGGSTNAFTSSEDTNYYFEVNADGFEEALDRFAQ 127
Query: 178 FFSCPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLG 237
FF PL + D+T +EI AV+SE++KNL +D WR+ QL K L+ HPYHKFSTG+ +TL
Sbjct: 128 FFIKPLMSADATTREIKAVDSEHQKNLLSDPWRMNQLQKHLSAENHPYHKFSTGSWDTLE 187
Query: 238 TLPKENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGREVPL 297
PKE G++ R ELLKF+ YSANLM L + ++ LD + F+D+ N R
Sbjct: 188 VRPKERGIDTRQELLKFYSENYSANLMHLVVYSKDSLDKVEQLVRGKFQDIRNIDRNQIH 247
Query: 298 YAEPIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGSGSLL 357
+ EHLQ +++ P+K KL+I + + H++ P R L HLIGHEG GSL
Sbjct: 248 FTGQPCIMEHLQILVRAVPIKQGHKLKIIWPITPGIHHYKEGPCRYLGHLIGHEGEGSLF 307
Query: 358 AHLKKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLPQ 417
LKKLGWA LSAG + +FF V IDLTD G H+ D++ L+F+YI +L+ +
Sbjct: 308 YVLKKLGWATSLSAGESDWTNEFSFFKVAIDLTDAGQDHFEDIMGLLFKYIHLLQQAGAS 367
Query: 418 KWIFNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRILAMGLLTKYEPDLLTQ 477
KWIF EL I F ++ PS V ++A ++ Y P ++A L +K+ P ++
Sbjct: 368 KWIFEELSAICETAFHYQDKIRPSDYVVNVAMNMQH-YPPEDWLVASSLPSKFNPSIIQS 426
Query: 478 YTDALVPENSRVTLISRSLETDS--AEKWYGTAYKVVDYPADLIKNMKSPGLNPALTLPR 535
+ + L P+N R+ S E ++ E WYGTAY + D IK + L LP
Sbjct: 427 FLNELNPDNVRIFWESTKFEGNTSMTEPWYGTAYSIEKVGGDSIKQWMEHAPSEELHLPA 486
Query: 536 PNEFVSTNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLPHTHA 595
PN F+ T+ + + P+LL S+LWYK D F P+ Y+ + F P+
Sbjct: 487 PNVFIPTDLSLKP--VFEKTKVPILLRKSPYSRLWYKPDTAFSSPKAYVMIDFSCPYCGH 544
Query: 596 SIINSMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLIILLTRF 655
S +L+ ++T+L D L + Y+A A L +KTN G +T G+N+KL +LL
Sbjct: 545 SPEAEVLTEIFTRLLMDYLNEYAYNAQVAGLYYDISKTNSGFQLTLFGYNDKLRVLLEAV 604
Query: 656 LQGVNSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKLQVFE 715
++ V FE K DRF ++K+ + +N ++ PY Q+ Y + ++ + W E+L V
Sbjct: 605 IEKVAKFEVKPDRFSVVKELVTKQYQNFKFQQPYQQVMYYCSLLLKDNIWPWNEELDVLP 664
Query: 716 KLTFEQLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPN-----NIHNLQVSN 770
L + L+ F P + + E + GN++ EA + LI+ + + +
Sbjct: 665 HLKVDDLVKFYPLLMARSFMECYVAGNVEQAEAESMIQLIEDVFFKGPQSISKPLFASQH 724
Query: 771 NRLRSYLLPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFAQLIHEPCFD 830
R L +G + Y + + NS + H Q+ L+ LFA + +P F
Sbjct: 725 LTNRVVNLERGVNYVYAAEGLNPSDENSALVHYIQVHQDDFMLNVKLQLFALIAKQPAFH 784
Query: 831 TLRTKEQLGYVVFSSSLNNHGTANIRILIQSEHTTP-YLEWRINNFYETFGQVLRDMPEE 889
LR+ EQLGY+ ++ G ++ ++QS P Y++ R+ F + F L +M +
Sbjct: 785 QLRSVEQLGYITVLMQRSDSGVHGVQFIVQSTAKDPKYIDTRVELFMKMFESKLYEMTSD 844
Query: 890 DFEKHKEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMIDFY 949
+F+ + AL + L+K KN+ EES Y I G F R ++ + +T++++ DF+
Sbjct: 845 EFKNNVNALIDMKLEKHKNLREESRFYWREISDGTLKFDRRDREIVALKQLTQKELTDFF 904
Query: 950 ENYIM--SENASKLILHLKSQVENKELNENELDTAKYPTGQLIEDVGAFKSTLFVA 1003
+ YI L + + + + + + P IE++ +F+ + +
Sbjct: 905 DEYIKVGVPRKKALSVRVYGSSHSSQF-QAHKNEQMEPNAVQIEEIFSFRRSRPLY 959
>ref|XP_956166.1| hypothetical protein NCU00481 [Neurospora crassa OR74A]
gb|EAA26930.1| hypothetical protein NCU00481 [Neurospora crassa OR74A]
Length = 1082
Score = 1023 bits (2646), Expect = 0.0, Method: Composition-based stats.
Identities = 378/960 (39%), Positives = 568/960 (59%), Gaps = 27/960 (2%)
Query: 50 PYNMTSNFKTFNLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFED 109
P + + KP LD+RSYR I LPNKL+ALL+ DP DKA+A+LDVN+G+F D
Sbjct: 9 PSKGSPAVERVTDQLEKPSLDDRSYRVIRLPNKLEALLVHDPTTDKASAALDVNVGSFSD 68
Query: 110 PKNLPGLAHFCEHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEV------ 163
++PG+AH EHLLFMG++K+P EN+YS YLS + GSSNA+TA+ +TNY+FEV
Sbjct: 69 EDDMPGMAHAVEHLLFMGTKKYPVENDYSQYLSTNSGSSNAFTAATHTNYYFEVSAKPSN 128
Query: 164 -------NHQHLFGALDRFSGFFSCPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDK 216
N L+GALDRF+ FF PLF ++ D+E+ AV+SENKKNLQND WR++QLDK
Sbjct: 129 DEELSATNPSPLYGALDRFAQFFVAPLFLANTLDRELRAVDSENKKNLQNDTWRLHQLDK 188
Query: 217 SLTNTKHPYHKFSTGNIETLGTLPKENGLNVRDELLKFHKNFYSANLMKLCILGREDLDT 276
S++N KHPY FSTGN+ETL LP+ G+NVR++ ++F++ YSAN MKLC+LGRE LD
Sbjct: 189 SISNPKHPYCHFSTGNLETLKVLPESKGVNVREKFIEFYQKHYSANRMKLCVLGREPLDV 248
Query: 277 LSDWTYDLFKDVANNGREVPLYAEP-IMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEH 335
L W +LF DV N + + + PE L + +PV D ++L I+F D
Sbjct: 249 LEGWVAELFSDVENKDLPPNEWTDEAPLTPEQLGVVTFAKPVMDSRELNITFPFLDEHLL 308
Query: 336 WESKPPRILSHLIGHEGSGSLLAHLKKLGWANELSAGGHTVSKG-NAFFAVDIDLTDNGL 394
+E P R LSHL+GHEG GS++AH+K GWAN LSAG TV G F + I LT GL
Sbjct: 309 FEELPSRYLSHLLGHEGPGSIMAHIKSKGWANGLSAGAWTVCPGSPGMFDIQIKLTQEGL 368
Query: 395 THYRDVIVLIFQYIEMLKNSLPQKWIFNELQDISNATFKFKQAGSPSSTVSSLAKCLEKD 454
+Y +V+ ++FQYI +LK + PQ+WI NE + + + FKFKQ SS S A +++
Sbjct: 369 KNYEEVVKVVFQYIALLKQTGPQEWIHNEQKIMGDIDFKFKQKTQASSFASKTAGVMQRP 428
Query: 455 YIPVSRILAMGLLTKYEPDLLTQYTDALVPENSRVTLISRSLE--TDSAEKWYGTAYKVV 512
+ L KY+ +L+ + D L P+N R++++SR + + E+WYGT Y V
Sbjct: 429 LPREWLLSGTSKLRKYDANLIRKGLDCLRPDNFRMSIVSREVPGKWEHKERWYGTEYSVS 488
Query: 513 DYPADLIKNMKSPGLN------PALTLPRPNEFVSTNFKVDKIDGIKPLDEPVLLLSDDV 566
P++L++ +K P L LP N+F+ T +V++ + +P P ++ +DD+
Sbjct: 489 KIPSELMEEIKKAATISDQERIPDLHLPHKNQFIPTKLEVERKEVKEPALAPRIVRNDDL 548
Query: 567 SKLWYKKDDRFWQPRGYIYLSFKLPHTHASIINSMLSTLYTQLANDALKDVQYDAACADL 626
+ WYKKDD FW P+ + +S K P HAS + + + L+T DAL++ YDA A L
Sbjct: 549 VRTWYKKDDTFWVPKANLIVSMKSPLIHASAESVVKARLFTDHVKDALEEFSYDADLAGL 608
Query: 627 RISFNKTNQGLAITASGFNEKLIILLTRFLQGVNSFEPKKDRFEILKDKTIRHLKNLLYE 686
+ ++GL + SG+N+KL +LL R L + E + DRF+I+K++ R +N +
Sbjct: 609 SYLVSLDSRGLFVEVSGYNDKLPLLLERVLITMRDLEVRDDRFDIIKERLTRAYRNWELQ 668
Query: 687 VPYSQMSNYYNAIINERSWSTAEKLQVFEKLTFEQLINFIPTIYEGVYFETLIHGNIKHE 746
VP+ Q+ + + E + E +T + + F + ++ E IHGN+ E
Sbjct: 669 VPWYQVGGFTEWLTAEHDHTIEELAAELPHITSDHVRQFRKALLAQLHMEVYIHGNLYKE 728
Query: 747 EALEVDSLIKSLIPNNIHNLQVSNNRLRSYLLPKGKTFRYETALKDSQNVNSCIQHVTQL 806
+AL++ +++S + + + LRS +LP G + ++ LKD NVN+CI++ +
Sbjct: 729 DALKLTDMVESTLKPRVLP-RSQWPILRSLVLPPGSNYVWKKTLKDPANVNNCIEYFLYV 787
Query: 807 DVYSEDL-SALSGLFAQLIHEPCFDTLRTKEQLGYVVFSSSLNNHGTANIRILIQSEHTT 865
++ L A + L AQ++ EPCFD LRTKEQLGYVVFS + R LIQSE T
Sbjct: 788 GDKNDSLIRAKTLLLAQILQEPCFDQLRTKEQLGYVVFSGVRATSTSYGFRFLIQSEKTA 847
Query: 866 PYLEWRINNFYETFGQVLRDMPEEDFEKHKEALCNSLLQKFKNMAEESARYTAAIYLGDY 925
PYLE RI F E + + +M FE HK +L L+K K + +E+ + + I+ Y
Sbjct: 848 PYLENRIELFLERMAKWIEEMDPRQFEAHKRSLIVKRLEKPKFLDQETNKQWSQIHSEYY 907
Query: 926 NFTHRQKKAKLVANITKQQMIDFYENYI--MSENASKLILHLKSQVENKELNENELDTAK 983
+F Q+ A V +TK+++I+F+++YI S + +KL ++L++Q ++ + K
Sbjct: 908 DFEISQRDAAHVKPLTKEELIEFFKHYIHPSSPSRAKLAIYLEAQAKSDVTTAQITELVK 967
Database: All non-redundant GenBank CDS
translations+PDB+SwissProt+PIR+PRF excluding environmental samples
from WGS projects
Posted date: May 23, 2008 5:56 PM
Number of letters in database: 883,778,997
Number of sequences in database: 2,617,685
Database: /host/Blast/data/nr_perl/nr.01
Posted date: May 23, 2008 5:54 PM
Number of letters in database: 976,759,346
Number of sequences in database: 2,761,413
Database: /host/Blast/data/nr_perl/nr.02
Posted date: May 23, 2008 5:48 PM
Number of letters in database: 374,670,760
Number of sequences in database: 1,165,270
Database: /host/Blast/data/nr_perl/nr.03
Posted date: Apr 28, 2009 5:40 PM
Number of letters in database: 114,943,120
Number of sequences in database: 354,819
Lambda K H
0.312 0.156 0.404
Lambda K H
0.267 0.0479 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,783,046,565
Number of Sequences: 6899187
Number of extensions: 628966647
Number of successful extensions: 2025863
Number of sequences better than 10.0: 300
Number of HSP's better than 10.0 without gapping: 6817
Number of HSP's successfully gapped in prelim test: 4360
Number of HSP's that attempted gapping in prelim test: 1973270
Number of HSP's gapped (non-prelim): 24374
length of query: 1027
length of database: 2,350,152,223
effective HSP length: 145
effective length of query: 882
effective length of database: 1,349,770,108
effective search space: 1190497235256
effective search space used: 1190497235256
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.2 bits)
S2: 85 (37.1 bits)