BLASTP 2.2.17 [Aug-26-2007]
Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Reference for composition-based statistics:
Schäffer, Alejandro A., L. Aravind, Thomas L. Madden,
Schaffer, Alejandro A., L. Aravind, Thomas L. Madden,
Sergei Shavirin, John L. Spouge, Yuri I. Wolf,
Eugene V. Koonin, and Stephen F. Altschul (2001),
"Improving the accuracy of PSI-BLAST protein database searches with
composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005.
Query= YMR208W__[Saccharomyces_cerevisiae]
(443 letters)
Database: All non-redundant GenBank CDS
translations+PDB+SwissProt+PIR+PRF excluding environmental samples
from WGS projects
6,899,187 sequences; 2,350,152,223 total letters
Searching..................................................done
Results from round 1
Score E
Sequences producing significant alignments: (bits) Value
ref|NP_013935.1| Mevalonate kinase, acts in the biosynthesi... 890 0.0
gb|EDN64144.1| mevalonate kinase [Saccharomyces cerevisiae ... 887 0.0
dbj|BAA24409.1| mevalonate kinase [Saccharomyces cerevisiae] 499 e-139
ref|XP_001644409.1| hypothetical protein Kpol_1064p33 [Vand... 483 e-134
ref|XP_446138.1| unnamed protein product [Candida glabrata]... 449 e-124
ref|NP_985191.1| AER335Wp [Ashbya gossypii ATCC 10895] >gi|... 415 e-114
ref|XP_452532.1| unnamed protein product [Kluyveromyces lac... 402 e-110
ref|XP_001382664.2| mevalonate kinase [Pichia stipitis CBS ... 322 3e-86
ref|XP_723495.1| mevalonate kinase [Candida albicans SC5314... 317 1e-84
ref|XP_460851.1| hypothetical protein DEHA0F12188g [Debaryo... 313 2e-83
ref|XP_001527900.1| hypothetical protein LELG_00420 [Lodder... 295 4e-78
ref|XP_001593159.1| hypothetical protein SS1G_06081 [Sclero... 275 4e-72
ref|XP_001483309.1| hypothetical protein PGUG_04038 [Pichia... 275 7e-72
ref|XP_001911734.1| unnamed protein product [Podospora anse... 274 9e-72
ref|XP_001229023.1| hypothetical protein CHGG_02507 [Chaeto... 269 4e-70
ref|XP_961360.1| hypothetical protein NCU03633 [Neurospora ... 268 7e-70
ref|XP_386088.1| hypothetical protein FG05912.1 [Gibberella... 266 2e-69
ref|XP_001559870.1| hypothetical protein BC1G_01429 [Botryo... 264 1e-68
ref|XP_001214601.1| conserved hypothetical protein [Aspergi... 261 9e-68
ref|XP_500956.1| hypothetical protein [Yarrowia lipolytica]... 260 1e-67
ref|XP_001271672.1| mevalonate kinase [Aspergillus clavatus... 260 1e-67
ref|XP_001401587.1| hypothetical protein An04g02190 [Asperg... 260 2e-67
ref|XP_001821298.1| hypothetical protein [Aspergillus oryza... 259 4e-67
ref|XP_661473.1| hypothetical protein AN3869.2 [Aspergillus... 258 7e-67
ref|XP_370449.1| hypothetical protein MGG_06946 [Magnaporth... 256 2e-66
gb|EEH48028.1| mevalonate kinase [Paracoccidioides brasilie... 255 4e-66
ref|XP_001241830.1| hypothetical protein CIMG_05726 [Coccid... 253 2e-65
gb|EDP50156.1| mevalonate kinase [Aspergillus fumigatus A1163] 250 2e-64
ref|XP_752047.1| mevalonate kinase [Aspergillus fumigatus A... 249 4e-64
ref|XP_001267243.1| mevalonate kinase [Neosartorya fischeri... 246 2e-63
gb|EEH37797.1| mevalonate kinase [Paracoccidioides brasilie... 238 1e-60
ref|XP_001540400.1| conserved hypothetical protein [Ajellom... 209 3e-52
gb|EDU45497.1| mevalonate kinase [Pyrenophora tritici-repen... 199 4e-49
ref|XP_761643.1| hypothetical protein UM05496.1 [Ustilago m... 197 2e-48
ref|XP_001628178.1| predicted protein [Nematostella vectens... 193 2e-47
ref|XP_790690.1| PREDICTED: similar to Mevalonate kinase (M... 189 4e-46
ref|NP_592837.1| mevalonate kinase Erg12 (predicted) [Schiz... 179 3e-43
ref|XP_001836355.1| hypothetical protein CC1G_06440 [Coprin... 176 5e-42
ref|XP_645383.1| hypothetical protein DDBDRAFT_0168621 [Dic... 175 8e-42
ref|XP_001364115.1| PREDICTED: similar to mevalonate kinase... 172 6e-41
ref|XP_001657825.1| mevalonate kinase [Aedes aegypti] >gi|1... 172 7e-41
dbj|BAD92959.1| mevalonate kinase variant [Homo sapiens] 171 8e-41
emb|CAA53059.1| unnamed protein product [Hepatitis B virus] 171 1e-40
ref|NP_000422.1| mevalonate kinase [Homo sapiens] >gi|16700... 171 1e-40
gb|AAQ02416.1| mevalonate kinase [synthetic construct] 171 1e-40
ref|XP_543435.2| PREDICTED: similar to Mevalonate kinase (M... 171 1e-40
ref|XP_001846214.1| mevalonate kinase [Culex pipiens quinqu... 170 2e-40
ref|XP_001105759.1| PREDICTED: mevalonate kinase isoform 2 ... 167 1e-39
ref|XP_001730996.1| hypothetical protein MGL_1995 [Malassez... 167 1e-39
gb|AAX46713.1| mevalonate kinase [Bos taurus] 167 1e-39
ref|XP_567850.1| cystathionine beta-lyase [Cryptococcus neo... 167 2e-39
emb|CAM15186.1| novel protein similar to vertebrate mevalon... 167 2e-39
ref|XP_567851.1| cystathionine beta-lyase [Cryptococcus neo... 167 2e-39
ref|NP_001007350.1| hypothetical protein LOC492477 [Danio r... 166 3e-39
gb|AAX08684.1| mevalonate kinase [Bos taurus] 166 4e-39
ref|NP_001015528.1| mevalonate kinase [Bos taurus] >gi|7506... 166 4e-39
ref|NP_001064360.1| Os10g0329300 [Oryza sativa (japonica cu... 164 1e-38
ref|XP_001496887.1| PREDICTED: similar to mevalonate kinase... 163 3e-38
ref|XP_001779131.1| predicted protein [Physcomitrella paten... 162 7e-38
ref|NP_001093299.1| mevalonate kinase [Bombyx mori] >gi|146... 161 8e-38
emb|CAG08527.1| unnamed protein product [Tetraodon nigrovir... 159 5e-37
gb|AAL31086.1|AC091749_15 putative mevalonate kinase [Oryza... 157 2e-36
ref|XP_624545.2| PREDICTED: similar to Mevalonate kinase (M... 157 2e-36
ref|NP_076045.1| mevalonate kinase [Mus musculus] >gi|89281... 154 1e-35
gb|AAD45421.1|L77688_1 mevalonate kinase [Arabidopsis thali... 154 2e-35
ref|NP_198097.1| MK/MVK; mevalonate kinase [Arabidopsis tha... 153 3e-35
dbj|BAE28997.1| unnamed protein product [Mus musculus] 150 2e-34
ref|XP_319701.4| AGAP008947-PA [Anopheles gambiae str. PEST... 149 5e-34
emb|CAO17636.1| unnamed protein product [Vitis vinifera] 149 6e-34
ref|XP_001608063.1| PREDICTED: similar to mevalonate kinase... 146 3e-33
ref|NP_112325.1| mevalonate kinase [Rattus norvegicus] >gi|... 144 2e-32
ref|NP_001027412.1| CG33671 CG33671-PA [Drosophila melanoga... 142 6e-32
ref|XP_972334.1| PREDICTED: similar to mevalonate kinase [T... 139 4e-31
gb|ABD32397.1| Mevalonate and galactokinase [Medicago trunc... 138 7e-31
gb|ABK95983.1| unknown [Populus trichocarpa] 137 2e-30
gb|ABR68258.1| mevalonate kinase [Monodelphis domestica] 137 2e-30
gb|AAL18925.1|AF429384_1 mevalonate kinase [Hevea brasilien... 137 3e-30
gb|EAZ05750.1| hypothetical protein OsI_026982 [Oryza sativ... 134 1e-29
ref|XP_001794454.1| hypothetical protein SNOG_03909 [Phaeos... 134 2e-29
ref|XP_001105689.1| PREDICTED: mevalonate kinase isoform 1 ... 134 2e-29
gb|AAX46707.1| mevalonate kinase [Bos taurus] 131 1e-28
ref|YP_183887.1| mevalonate kinase [Thermococcus kodakarens... 127 2e-27
ref|NP_143478.1| mevalonate kinase [Pyrococcus horikoshii O... 126 3e-27
emb|CAN77024.1| hypothetical protein [Vitis vinifera] 125 6e-27
gb|EAY78050.1| hypothetical protein OsI_032009 [Oryza sativ... 124 2e-26
ref|NP_126232.1| mevalonate kinase [Pyrococcus abyssi GE5] ... 124 2e-26
ref|NP_579366.1| mevalonate kinase [Pyrococcus furiosus DSM... 123 3e-26
gb|EAZ15677.1| hypothetical protein OsJ_029886 [Oryza sativ... 122 4e-26
ref|XP_001900710.1| mevalonate kinase family protein [Brugi... 119 4e-25
ref|XP_918559.1| PREDICTED: similar to mevalonate kinase [M... 115 6e-24
ref|YP_920295.1| mevalonate kinase [Thermofilum pendens Hrk... 110 2e-22
ref|NP_001022868.1| Y42G9A.4c [Caenorhabditis elegans] >gi|... 110 3e-22
ref|NP_001022869.1| Y42G9A.4d [Caenorhabditis elegans] >gi|... 109 4e-22
ref|NP_001022867.1| Y42G9A.4b [Caenorhabditis elegans] >gi|... 108 8e-22
ref|YP_447890.1| putative mevalonate kinase [Methanosphaera... 108 8e-22
ref|ZP_01906658.1| mevalonate kinase [Plesiocystis pacifica... 103 3e-20
ref|YP_842907.1| mevalonate kinase [Methanosaeta thermophil... 100 2e-19
ref|YP_001547075.1| mevalonate kinase [Herpetosiphon aurant... 97 2e-18
ref|YP_684687.1| mevalonate kinase [uncultured methanogenic... 97 3e-18
ref|XP_001032429.2| DnaJ domain containing protein [Tetrahy... 96 5e-18
gb|EAW97870.1| mevalonate kinase (mevalonic aciduria), isof... 94 2e-17
ref|YP_566996.1| mevalonate kinase [Methanococcoides burton... 92 8e-17
emb|CAF88123.1| unnamed protein product [Tetraodon nigrovir... 88 1e-15
ref|YP_327075.1| mevalonate kinase [Natronomonas pharaonis ... 87 2e-15
ref|YP_001276466.1| mevalonate kinase [Roseiflexus sp. RS-1... 86 5e-15
ref|ZP_02015315.1| mevalonate kinase [Halorubrum lacusprofu... 86 5e-15
ref|YP_001040239.1| mevalonate kinase [Staphylothermus mari... 86 6e-15
ref|XP_001325649.1| mevalonate kinase family protein [Trich... 86 9e-15
ref|YP_001431846.1| mevalonate kinase [Roseiflexus castenho... 85 1e-14
ref|YP_134862.1| mevalonate kinase [Haloarcula marismortui ... 85 1e-14
ref|ZP_03999700.1| mevalonate kinase [Halogeometricum borin... 84 2e-14
ref|XP_001231562.1| PREDICTED: hypothetical protein [Gallus... 83 4e-14
ref|YP_001013073.1| Mevalonate kinase [Hyperthermus butylic... 82 7e-14
ref|YP_001274012.1| mevalonate kinase [Methanobrevibacter s... 82 1e-13
ref|XP_001567071.1| mevalonate kinase, putative [Leishmania... 81 1e-13
gb|ABG24208.1| mevalonate kinase [Arnebia euchroma] 79 5e-13
ref|NP_633786.1| mevalonate kinase [Methanosarcina mazei Go... 79 7e-13
ref|ZP_01465063.1| mevalonate kinase [Stigmatella aurantiac... 79 1e-12
ref|XP_793882.1| PREDICTED: similar to mevalonate kinase va... 78 2e-12
ref|XP_001666415.1| hypothetical protein CBG21109 [Caenorha... 77 2e-12
ref|YP_658630.1| mevalonate kinase [Haloquadratum walsbyi D... 77 3e-12
ref|YP_001620791.1| mevalonate kinase [Acholeplasma laidlaw... 77 4e-12
ref|YP_001581649.1| mevalonate kinase [Nitrosopumilus marit... 76 5e-12
ref|YP_001634502.1| mevalonate kinase [Chloroflexus auranti... 76 5e-12
ref|YP_804427.1| Mevalonate kinase [Pediococcus pentosaceus... 76 5e-12
ref|XP_844557.1| mevalonate kinase, putative [Trypanosoma b... 75 1e-11
ref|ZP_03871887.1| mevalonate kinase [Halorhabdus utahensis... 74 2e-11
ref|NP_341921.1| Mevalonate kinase [Sulfolobus solfataricus... 72 6e-11
ref|XP_001467381.1| mevalonate kinase [Leishmania infantum ... 72 8e-11
ref|NP_720650.1| putative mevalonate kinase [Streptococcus ... 72 1e-10
ref|ZP_03873469.1| mevalonate kinase [Halomicrobium mukohat... 71 2e-10
ref|XP_814628.1| mevalonate kinase, putative [Trypanosoma c... 70 3e-10
ref|XP_802528.1| mevalonate kinase, putative [Trypanosoma c... 69 5e-10
ref|XP_001744350.1| predicted protein [Monosiga brevicollis... 69 5e-10
ref|YP_633174.1| mevalonate kinase [Myxococcus xanthus DK 1... 68 1e-09
gb|EDL19907.1| mevalonate kinase, isoform CRA_a [Mus muscul... 67 2e-09
pdb|2HFU|A Chain A, Crystal Structure Of L. Major Mevalonat... 67 2e-09
ref|XP_001685041.1| mevalonate kinase, putative [Leishmania... 67 3e-09
ref|ZP_01514039.1| mevalonate kinase [Chloroflexus aggregan... 67 3e-09
pdb|1VIS|A Chain A, Crystal Structure Of Mevalonate Kinase 67 3e-09
ref|YP_001435347.1| mevalonate kinase [Ignicoccus hospitali... 67 4e-09
ref|NP_001022866.1| Y42G9A.4a [Caenorhabditis elegans] >gi|... 67 4e-09
pdb|1KKH|A Chain A, Crystal Structure Of The Methanococcus ... 67 4e-09
ref|NP_248080.1| mevalonate kinase [Methanocaldococcus jann... 67 4e-09
gb|EDM13938.1| mevalonate kinase, isoform CRA_b [Rattus nor... 67 4e-09
ref|ZP_02185318.1| mevalonate kinase [Carnobacterium sp. AT... 66 5e-09
gb|EDM13939.1| mevalonate kinase, isoform CRA_c [Rattus nor... 66 5e-09
ref|ZP_01695505.1| mevalonate kinase [Bacillus coagulans 36... 65 8e-09
ref|YP_808480.1| Mevalonate kinase [Lactococcus lactis subs... 65 1e-08
ref|YP_001197657.1| Mevalonate kinase [Streptococcus suis 0... 65 2e-08
pdb|2HFS|A Chain A, Crystal Structure Of L. Major Mevalonat... 64 2e-08
ref|ZP_00875673.1| Mevalonate kinase [Streptococcus suis 89... 64 2e-08
ref|YP_256937.1| mevalonate kinase [Sulfolobus acidocaldari... 63 4e-08
ref|YP_001031775.1| Mvk protein [Lactococcus lactis subsp. ... 63 6e-08
sp|Q50559|KIME_METTH Mevalonate kinase (MK) >gi|1184118|gb|... 62 7e-08
ref|XP_001708461.1| Mevalonate kinase [Giardia lamblia ATCC... 62 9e-08
ref|YP_001030120.1| hypothetical protein Mlab_0681 [Methano... 62 1e-07
ref|NP_275189.1| mevalonate kinase [Methanothermobacter the... 62 1e-07
ref|ZP_03940390.1| possible mevalonate kinase [Lactobacillu... 61 2e-07
ref|NP_378182.1| hypothetical protein ST2185 [Sulfolobus to... 61 2e-07
ref|NP_148611.1| mevalonate kinase [Aeropyrum pernix K1] >g... 61 2e-07
ref|NP_280049.1| Mvk [Halobacterium sp. NRC-1] >gi|16923595... 60 2e-07
ref|XP_001519270.1| PREDICTED: hypothetical protein, partia... 60 2e-07
ref|XP_001458185.1| hypothetical protein GSPATT00003653001 ... 60 3e-07
ref|YP_001540788.1| mevalonate kinase [Caldivirga maquiling... 60 3e-07
ref|NP_819638.1| phosphomevalonate kinase, putative [Coxiel... 60 4e-07
ref|YP_001737496.1| mevalonate kinase [Candidatus Korarchae... 60 4e-07
ref|NP_266560.1| mevalonate kinase [Lactococcus lactis subs... 60 4e-07
ref|NP_463543.1| hypothetical protein lmo0010 [Listeria mon... 60 5e-07
ref|NP_691146.1| mevalonate kinase [Oceanobacillus iheyensi... 60 5e-07
ref|ZP_00604007.1| Mevalonate kinase [Enterococcus faecium ... 59 6e-07
ref|ZP_01946351.1| mevalonate kinase [Coxiella burnetii 'MS... 59 7e-07
ref|YP_848214.1| mevalonate kinase [Listeria welshimeri ser... 59 7e-07
ref|ZP_03943398.1| possible mevalonate kinase [Lactobacillu... 59 8e-07
ref|ZP_03980950.1| possible Mevalonate kinase [Enterococcus... 59 1e-06
ref|YP_012624.1| mevalonate kinase [Listeria monocytogenes ... 59 1e-06
ref|ZP_00230799.1| mevalonate kinase [Listeria monocytogene... 58 1e-06
ref|ZP_01926008.1| mevalonate kinase [Listeria monocytogene... 58 1e-06
ref|ZP_01942559.1| mevalonate kinase [Listeria monocytogene... 58 1e-06
ref|NP_469357.1| hypothetical protein lin0010 [Listeria inn... 58 1e-06
ref|YP_504301.1| mevalonate kinase [Methanospirillum hungat... 58 2e-06
dbj|BAB07790.1| mevalonate kinase [Streptomyces sp. CL190] 58 2e-06
ref|NP_819639.1| mevalonate kinase, putative [Coxiella burn... 57 2e-06
ref|ZP_03954541.1| possible mevalonate kinase [Lactobacillu... 57 3e-06
ref|YP_001405370.1| mevalonate kinase [Candidatus Methanore... 56 5e-06
gb|ABR67422.1| mevalonate kinase 1 [Cucumis melo] 56 7e-06
ref|ZP_02689018.1| mevalonate kinase [Listeria monocytogene... 55 9e-06
ref|YP_001424028.1| putative phopshomevalonate kinase [Coxi... 55 1e-05
ref|NP_071114.1| mevalonate kinase (mvk) [Archaeoglobus ful... 55 1e-05
ref|ZP_03882650.1| mevalonate kinase [Haliangium ochraceum ... 55 1e-05
ref|YP_001191681.1| mevalonate kinase [Metallosphaera sedul... 55 1e-05
dbj|BAE78977.1| mevalonate kinase [Streptomyces sp. KO-3988] 54 2e-05
ref|XP_001347016.1| Mevalonate kinase, putative [Paramecium... 53 5e-05
ref|NP_645362.1| mevalonate kinase [Staphylococcus aureus s... 53 5e-05
ref|YP_806709.1| Mevalonate kinase [Lactobacillus casei ATC... 52 7e-05
ref|NP_614276.1| Mevalonate kinase [Methanopyrus kandleri A... 52 9e-05
ref|NP_905758.1| galactokinase [Porphyromonas gingivalis W8... 52 1e-04
ref|YP_040044.1| mevalonate kinase [Staphylococcus aureus s... 52 1e-04
ref|YP_001614848.1| hypothetical protein sce4205 [Sorangium... 52 1e-04
ref|ZP_03852846.1| possible Galactokinase [Chryseobacterium... 51 1e-04
gb|AAG02424.1|AF290087_1 mevalonate kinase [Staphylococcus ... 51 2e-04
ref|ZP_03947872.1| mevalonate kinase [Enterococcus faecalis... 51 2e-04
gb|AAG02440.1|AF290093_1 mevalonate kinase [Enterococcus fa... 51 2e-04
ref|NP_814642.1| mevalonate kinase [Enterococcus faecalis V... 51 2e-04
emb|CAL34097.1| putative mevalonate kinase [Streptomyces ci... 50 3e-04
ref|YP_810664.1| Mevalonate kinase [Oenococcus oeni PSU-1] ... 50 3e-04
ref|YP_001329799.1| mevalonate kinase [Methanococcus maripa... 50 3e-04
ref|XP_001618047.1| hypothetical protein NEMVEDRAFT_v1g6609... 50 3e-04
ref|NP_615566.1| mevalonate kinase [Methanosarcina acetivor... 50 4e-04
ref|ZP_01544345.1| mevalonate kinase [Oenococcus oeni ATCC ... 50 4e-04
ref|YP_304960.1| mevalonate kinase [Methanosarcina barkeri ... 50 5e-04
dbj|BAD86800.1| mevalonate kinase [Streptomyces sp. KO-3988] 50 5e-04
ref|YP_001096789.1| mevalonate kinase [Methanococcus maripa... 49 6e-04
ref|YP_001928600.1| putative galactokinase [Porphyromonas g... 49 6e-04
gb|AAF82406.1| truncated mevalonate kinase [Homo sapiens] 49 7e-04
ref|NP_968513.1| hypothetical protein Bd1630 [Bdellovibrio ... 49 9e-04
ref|NP_371114.1| mevalonate kinase [Staphylococcus aureus s... 49 0.001
ref|YP_795031.1| Mevalonate kinase [Lactobacillus brevis AT... 49 0.001
ref|YP_001549383.1| mevalonate kinase [Methanococcus maripa... 49 0.001
ref|YP_001844008.1| mevalonate kinase [Lactobacillus fermen... 48 0.002
ref|ZP_03944901.1| possible mevalonate kinase [Lactobacillu... 48 0.002
ref|NP_212822.1| mevalonate kinase [Borrelia burgdorferi B3... 48 0.002
ref|ZP_02520518.1| mevalonate kinase [Borrelia burgdorferi ... 48 0.002
ref|XP_955731.1| mevalonate kinase [Encephalitozoon cunicul... 47 0.003
ref|NP_560495.1| mevalonate kinase [Pyrobaculum aerophilum ... 47 0.003
ref|NP_988455.1| Mevalonate kinase [Methanococcus maripalud... 47 0.003
ref|YP_598349.1| Mevalonate kinase [Streptococcus pyogenes ... 47 0.003
ref|ZP_03957037.1| mevalonate kinase [Lactobacillus ruminis... 47 0.004
ref|ZP_02725132.1| mevalonate kinase [Borrelia burgdorferi ... 47 0.004
ref|YP_194037.1| mevalonate kinase [Lactobacillus acidophil... 47 0.005
ref|YP_001193466.1| galactokinase [Flavobacterium johnsonia... 46 0.005
ref|YP_818851.1| Mevalonate kinase [Leuconostoc mesenteroid... 46 0.006
ref|ZP_03913910.1| mevalonate kinase [Leuconostoc mesentero... 46 0.006
ref|ZP_03807562.1| mevalonate kinase [Lactobacillus jenseni... 46 0.007
ref|ZP_02519050.1| mevalonate kinase [Borrelia burgdorferi ... 46 0.007
gb|ABS50475.1| NapT6 [Streptomyces sp. CNQ525] 46 0.007
ref|NP_664399.1| mevalonate kinase [Streptococcus pyogenes ... 46 0.008
ref|ZP_01446658.1| galactokinase [alpha proteobacterium HTC... 45 0.008
ref|YP_395519.1| Mevalonate kinase [Lactobacillus sakei sub... 45 0.008
ref|ZP_03956255.1| mevalonate kinase [Lactobacillus jenseni... 45 0.008
ref|NP_607080.1| mevalonate kinase [Streptococcus pyogenes ... 45 0.009
ref|YP_302212.1| mevalonate kinase [Staphylococcus saprophy... 45 0.009
ref|YP_001324970.1| mevalonate kinase [Methanococcus aeolic... 45 0.009
ref|YP_060017.1| Mevalonate kinase [Streptococcus pyogenes ... 45 0.010
ref|XP_001600084.1| PREDICTED: similar to Galactokinase 1 [... 45 0.010
ref|ZP_02719710.1| mevalonate kinase [Borrelia burgdorferi ... 45 0.010
ref|NP_785308.1| mevalonate kinase [Lactobacillus plantarum... 45 0.011
ref|ZP_03959183.1| possible mevalonate kinase [Lactobacillu... 45 0.014
ref|YP_391998.1| GHMP kinase [Thiomicrospira crunogena XCL-... 45 0.014
ref|NP_269075.1| mevalonate kinase [Streptococcus pyogenes ... 45 0.014
ref|YP_391999.1| GHMP kinase [Thiomicrospira crunogena XCL-... 45 0.014
dbj|BAB07817.1| mevalonate kinase [Kitasatospora griseola] 45 0.015
ref|YP_280130.1| mevalonate kinase [Streptococcus pyogenes ... 45 0.016
ref|YP_001047720.1| mevalonate kinase [Methanoculleus maris... 45 0.016
ref|YP_820062.1| Mevalonate kinase [Streptococcus thermophi... 44 0.018
ref|YP_001056718.1| mevalonate kinase [Pyrobaculum calidifo... 44 0.025
ref|YP_001153805.1| mevalonate kinase [Pyrobaculum arsenati... 44 0.025
ref|NP_972898.1| galactokinase, putative [Treponema dentico... 44 0.026
gb|ABS50448.1| NapT6 [Streptomyces aculeolatus] 44 0.026
ref|YP_395517.1| Phosphomevalonate kinase [Lactobacillus sa... 44 0.028
ref|YP_814846.1| Mevalonate kinase [Lactobacillus gasseri A... 44 0.030
ref|YP_001851498.1| mevalonate kinase, Erg12 [Mycobacterium... 44 0.031
ref|YP_140970.1| mevalonate kinase [Streptococcus thermophi... 44 0.034
ref|ZP_03951014.1| mevalonate kinase [Lactobacillus gasseri... 43 0.043
ref|ZP_03808267.1| mevalonate kinase [Lactobacillus gasseri... 43 0.043
ref|YP_001323164.1| mevalonate kinase [Methanococcus vannie... 43 0.047
ref|NP_688324.1| mevalonate kinase, putative [Streptococcus... 43 0.048
ref|ZP_01059235.1| galactokinase [Flavobacterium sp. MED217... 43 0.054
gb|AAO45760.1| mevalonate kinase-like protein [Cucumis melo] 43 0.054
ref|YP_139080.1| mevalonate kinase [Streptococcus thermophi... 43 0.060
ref|ZP_04007834.1| possible mevalonate kinase [Lactobacillu... 42 0.070
ref|NP_001085920.1| MGC82807 protein [Xenopus laevis] >gi|4... 42 0.086
ref|ZP_03845964.1| mevalonate kinase [Lactobacillus sakei s... 42 0.094
emb|CAF89434.1| unnamed protein product [Tetraodon nigrovir... 42 0.10
ref|ZP_03898469.1| galactokinase [Dyadobacter fermentans DS... 42 0.11
ref|NP_001072199.1| hypothetical protein LOC779645 [Xenopus... 42 0.11
ref|ZP_01167630.1| GHMP kinase [Oceanospirillum sp. MED92] ... 42 0.11
ref|XP_568351.1| galactokinase [Cryptococcus neoformans var... 42 0.11
ref|XP_772220.1| hypothetical protein CNBM0530 [Cryptococcu... 42 0.11
ref|YP_920516.1| GHMP kinase [Thermofilum pendens Hrk 5] >g... 42 0.12
gb|ACC62032.1| mevalonate kinase [Picrorhiza kurrooa] 41 0.16
ref|NP_763918.1| phosphomevalonate kinase [Staphylococcus e... 41 0.16
ref|YP_073131.1| mevalonate kinase, putative [Borrelia gari... 41 0.17
ref|ZP_01131025.1| galactokinase [marine actinobacterium PH... 41 0.17
ref|YP_001180295.1| galactokinase [Caldicellulosiruptor sac... 41 0.18
ref|NP_965060.1| mevalonate kinase [Lactobacillus johnsonii... 41 0.18
ref|ZP_03974667.1| mevalonate kinase [Lactobacillus reuteri... 41 0.19
ref|NP_559128.1| galactokinase [Pyrobaculum aerophilum str.... 41 0.20
ref|YP_907150.1| mevalonate kinase, Erg12 [Mycobacterium ul... 41 0.21
ref|ZP_01106208.1| galactokinase [Flavobacteriales bacteriu... 41 0.21
ref|ZP_03923457.1| galactokinase [Mobiluncus curtisii ATCC ... 41 0.23
ref|ZP_02069938.1| hypothetical protein BACUNI_01355 [Bacte... 41 0.25
ref|YP_254317.1| mevalonate kinase [Staphylococcus haemolyt... 40 0.27
ref|ZP_02368550.1| mevalonate kinase, putative [Borrelia va... 40 0.28
ref|XP_001841798.1| galactokinase [Culex pipiens quinquefas... 40 0.28
gb|EEJ98368.1| galactokinase [Thermomonospora curvata DSM 4... 40 0.29
ref|XP_001556809.1| hypothetical protein BC1G_04827 [Botryo... 40 0.31
ref|ZP_01117462.1| galactokinase [Polaribacter irgensii 23-... 40 0.36
ref|YP_001034342.1| Phosphomevalonate kinase, putative [Str... 40 0.39
ref|ZP_03959181.1| phosphomevalonate kinase [Lactobacillus ... 40 0.40
>ref|NP_013935.1| Mevalonate kinase, acts in the biosynthesis of isoprenoids and
sterols, including ergosterol, from mevalonate; Erg12p
[Saccharomyces cerevisiae]
sp|P07277|KIME_YEAST Mevalonate kinase (MK) (MvK)
emb|CAA39359.1| mevalonate kinase [Saccharomyces cerevisiae]
emb|CAA29487.1| unnamed protein product [Saccharomyces cerevisiae]
emb|CAA89923.1| Rar1p [Saccharomyces cerevisiae]
Length = 443
Score = 890 bits (2300), Expect = 0.0, Method: Composition-based stats.
Identities = 443/443 (100%), Positives = 443/443 (100%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFN 60
MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFN
Sbjct: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFN 60
Query: 61 HKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLY 120
HKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLY
Sbjct: 61 HKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLY 120
Query: 121 MFVCLCPHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLIGSNDLEKLSENDK 180
MFVCLCPHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLIGSNDLEKLSENDK
Sbjct: 121 MFVCLCPHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLIGSNDLEKLSENDK 180
Query: 181 HIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLDDFPAIPMI 240
HIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLDDFPAIPMI
Sbjct: 181 HIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLDDFPAIPMI 240
Query: 241 LTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSKCKGTDDEA 300
LTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSKCKGTDDEA
Sbjct: 241 LTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSKCKGTDDEA 300
Query: 301 VETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGAGGGGCSLT 360
VETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGAGGGGCSLT
Sbjct: 301 VETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGAGGGGCSLT 360
Query: 361 LLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLNKDLKIKSLVFQLFEN 420
LLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLNKDLKIKSLVFQLFEN
Sbjct: 361 LLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLNKDLKIKSLVFQLFEN 420
Query: 421 KTTTKQQIDDLLLPGNTNLPWTS 443
KTTTKQQIDDLLLPGNTNLPWTS
Sbjct: 421 KTTTKQQIDDLLLPGNTNLPWTS 443
>gb|EDN64144.1| mevalonate kinase [Saccharomyces cerevisiae YJM789]
Length = 443
Score = 887 bits (2293), Expect = 0.0, Method: Composition-based stats.
Identities = 442/443 (99%), Positives = 442/443 (99%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFN 60
MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFN
Sbjct: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFN 60
Query: 61 HKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLY 120
HKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLY
Sbjct: 61 HKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLY 120
Query: 121 MFVCLCPHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLIGSNDLEKLSENDK 180
MFVCLCPHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLIGSNDLEKLSENDK
Sbjct: 121 MFVCLCPHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLIGSNDLEKLSENDK 180
Query: 181 HIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLDDFPAIPMI 240
HIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLDDFPAIPMI
Sbjct: 181 HIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLDDFPAIPMI 240
Query: 241 LTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSKCKGTDDEA 300
LTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSKCKGTDDEA
Sbjct: 241 LTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSKCKGTDDEA 300
Query: 301 VETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGAGGGGCSLT 360
VETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGAGGGGCSLT
Sbjct: 301 VETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGAGGGGCSLT 360
Query: 361 LLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLNKDLKIKSLVFQLFEN 420
LLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLNKD KIKSLVFQLFEN
Sbjct: 361 LLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLNKDPKIKSLVFQLFEN 420
Query: 421 KTTTKQQIDDLLLPGNTNLPWTS 443
KTTTKQQIDDLLLPGNTNLPWTS
Sbjct: 421 KTTTKQQIDDLLLPGNTNLPWTS 443
>dbj|BAA24409.1| mevalonate kinase [Saccharomyces cerevisiae]
Length = 246
Score = 499 bits (1284), Expect = e-139, Method: Composition-based stats.
Identities = 246/246 (100%), Positives = 246/246 (100%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFN 60
MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFN
Sbjct: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFN 60
Query: 61 HKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLY 120
HKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLY
Sbjct: 61 HKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLY 120
Query: 121 MFVCLCPHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLIGSNDLEKLSENDK 180
MFVCLCPHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLIGSNDLEKLSENDK
Sbjct: 121 MFVCLCPHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLIGSNDLEKLSENDK 180
Query: 181 HIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLDDFPAIPMI 240
HIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLDDFPAIPMI
Sbjct: 181 HIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLDDFPAIPMI 240
Query: 241 LTYTRI 246
LTYTRI
Sbjct: 241 LTYTRI 246
>ref|XP_001644409.1| hypothetical protein Kpol_1064p33 [Vanderwaltozyma polyspora DSM
70294]
gb|EDO16551.1| hypothetical protein Kpol_1064p33 [Vanderwaltozyma polyspora DSM
70294]
Length = 421
Score = 483 bits (1244), Expect = e-134, Method: Composition-based stats.
Identities = 246/440 (55%), Positives = 326/440 (74%), Gaps = 23/440 (5%)
Query: 3 LPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFNHK 62
+PF+TSAPGKVIIFGEHSAVYN+PAVAASVS+LRT+LL+ + + DT+ L+FPDI F+H+
Sbjct: 2 IPFITSAPGKVIIFGEHSAVYNEPAVAASVSSLRTFLLVEDGAHRDTVALNFPDIKFHHE 61
Query: 63 WSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLD-PLLAQLSESFHYHAAFCFLYM 121
W ++ + + + L KA++ T+ LSQ LV+LL+ LL L ES H+HAAFCF+Y+
Sbjct: 62 WRHSEIHQVIKLAEADGLLTKARKDTNNLSQPLVTLLEEKLLGSLKESLHFHAAFCFIYL 121
Query: 122 FVCLCPHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLIGSNDLEKLSENDKH 181
+VCLCP+ ++KFSLKSTLPIGAGLGSSASISV+L+LAMA LGG I S E L+ DK
Sbjct: 122 YVCLCPNVNHVKFSLKSTLPIGAGLGSSASISVALSLAMAKLGGHIKST--ESLTSADKK 179
Query: 182 IVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLDDFPAIPMIL 241
+N W+FIGEKCIHGTPSGIDNAVATYGNA+LF+K+ + T NF+F+D+FP IPMIL
Sbjct: 180 YINSWSFIGEKCIHGTPSGIDNAVATYGNAVLFKKEDNGST----NFQFIDNFPKIPMIL 235
Query: 242 TYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSKCKGTDDEAV 301
TYTRIPRSTK LV+ VR LV EK+P + KPIL +MG A G +I+ L
Sbjct: 236 TYTRIPRSTKVLVSNVRELV-EKYPSIFKPILQSMGHLANDGADILRNL----------- 283
Query: 302 ETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGAGGGGCSLTL 361
N++ Y LLEL+R+NHGLLVS+GVSHPGLE+IK+LSD + +GSTKLTGAGGGGCSLT+
Sbjct: 284 --NDKNYNDLLELVRVNHGLLVSLGVSHPGLEIIKSLSDTMDLGSTKLTGAGGGGCSLTI 341
Query: 362 LRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLNKDLKIKSLVFQLFENK 421
L++D+TQ+QI +FK L++ +Y T++TDLGG GC +S ++ + I ++ + E +
Sbjct: 342 LKKDVTQDQIKTFKSILKEKHNYGTYDTDLGGMGCSFVSLDSIPEKDAI--VIKAILEAR 399
Query: 422 TTTKQQIDDLLLPGNTNLPW 441
+ ++Q+ L + L W
Sbjct: 400 ESPREQLTKFLFSDESVLTW 419
>ref|XP_446138.1| unnamed protein product [Candida glabrata]
emb|CAG59062.1| unnamed protein product [Candida glabrata CBS 138]
Length = 430
Score = 449 bits (1154), Expect = e-124, Method: Composition-based stats.
Identities = 243/441 (55%), Positives = 314/441 (71%), Gaps = 35/441 (7%)
Query: 3 LPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISE--SSAPDTIELDFPDISFN 60
LPFL SAPGKVI+FGEHSAVYN+PAVAASVS+LRTYLL+S S+A D+IEL FPDI F+
Sbjct: 7 LPFLVSAPGKVILFGEHSAVYNEPAVAASVSSLRTYLLVSPAGSNAEDSIELSFPDIGFD 66
Query: 61 HKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLY 120
H W + + + + L A++ T L++ELV LL+ +L L ES HYHAAFCFLY
Sbjct: 67 HVWKRKELEPVLRE---TALLQAAREDTKNLNEELVGLLNVILEPLKESLHYHAAFCFLY 123
Query: 121 MFVCLCPHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLIGSNDLEKLSENDK 180
+F LCP A NIKFS+KSTLPIGAGLGSSA+ISVSLA+AM LGG + + E LS DK
Sbjct: 124 LFCTLCPSATNIKFSVKSTLPIGAGLGSSAAISVSLAMAMLRLGGKLVTG--ESLSGEDK 181
Query: 181 HIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLDDFP--AIP 238
++N+WAFIGEKCIHGTPSGIDNAVATYGNA+LF++ + T +F+FLD F IP
Sbjct: 182 ALINEWAFIGEKCIHGTPSGIDNAVATYGNAVLFKRSADG----TTDFEFLDKFHELKIP 237
Query: 239 MILTYTRIPRSTKDLVARVRVLVTEKFPEVMKP-ILDAMGECALQGLEIMTKLSKCKGTD 297
M+LTYTRIPRSTK LV+ VR L + K+P+V++ ++ AMGE AL+ ++I+
Sbjct: 238 MVLTYTRIPRSTKVLVSSVRDL-SNKYPKVIQDHVIKAMGELALESVDIL---------- 286
Query: 298 DEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGAGGGGC 357
+ + N+ YE+LL+L+ INHGLLV+IGVSHPGLE+I+NLS IG+TKLTGAGGGGC
Sbjct: 287 NSGIGGNDSNYERLLDLVNINHGLLVAIGVSHPGLEIIRNLSITNSIGATKLTGAGGGGC 346
Query: 358 SLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCL---LSAKNLNKDLKIKSLV 414
+ T+L +D+ Q ++D FK++L Y +F ++LGG G C+ L A+ N LV
Sbjct: 347 AFTVLNKDVPQTEVDKFKEELSKKHGYLSFTSELGGAGSCMTPTLVAEQYN-------LV 399
Query: 415 FQLFENKTTTKQQIDDLLLPG 435
LFEN K+++D LLP
Sbjct: 400 APLFENTENNKEELDKTLLPA 420
>ref|NP_985191.1| AER335Wp [Ashbya gossypii ATCC 10895]
gb|AAS53015.1| AER335Wp [Ashbya gossypii ATCC 10895]
Length = 428
Score = 415 bits (1066), Expect = e-114, Method: Composition-based stats.
Identities = 214/440 (48%), Positives = 292/440 (66%), Gaps = 29/440 (6%)
Query: 3 LPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFNHK 62
LPF+TSAPGKVIIFGEHSAVYNKPA+AASVS+LRTYL + + D + ++FPDI F +
Sbjct: 14 LPFITSAPGKVIIFGEHSAVYNKPAIAASVSSLRTYLFVEADAESDAVRMEFPDIGFQYS 73
Query: 63 WSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLYMF 122
W A+ + V ++ L E+++ +D LL L + HAA CFLY++
Sbjct: 74 WKHEALTAVPREAVVRAFCSRE------LDAEVLAHVDRLLMGLEGALARHAALCFLYIY 127
Query: 123 VCLCPHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLIGSNDLEKLSENDKHI 182
CLC + ++F++KSTLPIGAGLGSSASI+V LALAM LGG + L++ +
Sbjct: 128 TCLCREVQGVRFTVKSTLPIGAGLGSSASIAVCLALAMGRLGGHVQCES-GALTKEQQDF 186
Query: 183 VNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLDDFPAIPMILT 242
VN+WA +GE+CIHGTPSGIDNAVATYG+A+LF++ T F L DFP +PMILT
Sbjct: 187 VNRWALVGEQCIHGTPSGIDNAVATYGDAVLFQRQPDGST----KFDHLSDFPQMPMILT 242
Query: 243 YTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSKCKGTDDEAVE 302
T++P+STK LVA V LV E+ P + PIL+ M + Q E++ L +
Sbjct: 243 NTKVPKSTKVLVANVGKLV-EQEPLITAPILNTMAQVVTQAHELLPLL-----------Q 290
Query: 303 TNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGAGGGGCSLTLL 362
++ +Y +LL+L+RINHGLLV++GVSHP LE ++ L D L IG+TKLTGAGGGGC+LTLL
Sbjct: 291 GDDTVYTRLLQLVRINHGLLVALGVSHPSLEHVRALCDTLGIGATKLTGAGGGGCALTLL 350
Query: 363 RRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLNKDL-KIKSLVFQLFENK 421
+RD+ E ++ F+K L D YE+F T LGG GCCL +++ + L +IK+L FQ +
Sbjct: 351 KRDVEDELVEQFRKTLLDKHGYESFTTGLGGVGCCLATSQTIRPHLDRIKTL-FQ----E 405
Query: 422 TTTKQQIDDLLLPGNTNLPW 441
T +QQ+ + LLPG + + W
Sbjct: 406 DTPQQQLAEALLPGASPIDW 425
>ref|XP_452532.1| unnamed protein product [Kluyveromyces lactis]
emb|CAH01383.1| unnamed protein product [Kluyveromyces lactis NRRL Y-1140]
Length = 419
Score = 402 bits (1033), Expect = e-110, Method: Composition-based stats.
Identities = 226/441 (51%), Positives = 297/441 (67%), Gaps = 32/441 (7%)
Query: 4 PFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFNHKW 63
PF+ SAPGKVIIFGEHSAV+NK A+AASVS+LRTYLLI +S D +ELDFPDI+++ KW
Sbjct: 10 PFIVSAPGKVIIFGEHSAVFNKNAIAASVSSLRTYLLIEQSKDGDGVELDFPDINYDSKW 69
Query: 64 SINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLYMFV 123
S + I + V K L +L L+ LL L +S +Y+AA FLY+++
Sbjct: 70 STEELKTIDSEVV------KQAAGLKHLCPKLKEQLNLLLEGLKDSLNYYAALSFLYLYL 123
Query: 124 CLCPHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLIGSNDLEKLSENDKHIV 183
LCP+ K +KF++KSTLPIGAGLGSSASISV LALAMA +GG I + + +S+ +K +
Sbjct: 124 SLCPNVKGLKFTVKSTLPIGAGLGSSASISVCLALAMARMGGHISCD--KSISQEEKEFI 181
Query: 184 NQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLDDFPAIPMILTY 243
N WAFIGE CIHGTPSGIDNAVATYGNA+ F++ T F + +FP +PM+LT
Sbjct: 182 NHWAFIGECCIHGTPSGIDNAVATYGNAVKFKRQEDGST----KFDQISNFPQLPMVLTN 237
Query: 244 TRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSKCKGTDDEAVET 303
TRI RSTK LV+ V LV K P + +PIL+AM + AL+G E+++ +SK
Sbjct: 238 TRIKRSTKILVSGVGDLVNRK-PLITEPILEAMNQVALRGSELLSDISK----------- 285
Query: 304 NNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGAGGGGCSLTLLR 363
+ Y++LLELIRINHGLLV+IGVSHPGLE+IK LSD+L+IG TKLTGAGGGGC+ TLL
Sbjct: 286 -DIHYDELLELIRINHGLLVAIGVSHPGLEVIKQLSDELKIGQTKLTGAGGGGCAFTLLN 344
Query: 364 RDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLNKDLKIKSLVFQLFENKTT 423
+D+ + F +KL ++ Y+ FET LGG GCC + KN + +K L +
Sbjct: 345 KDVDHSSVRKFHEKLHSNYGYQIFETGLGGVGCCFVDLKNEQYE-SLKHLFID-----SA 398
Query: 424 TKQQIDDLLLPG-NTNLPWTS 443
T Q++ LLP + +L WT+
Sbjct: 399 TVQEVSLALLPSPDGSLTWTA 419
>ref|XP_001382664.2| mevalonate kinase [Pichia stipitis CBS 6054]
gb|ABN64635.2| mevalonate kinase [Pichia stipitis CBS 6054]
Length = 432
Score = 322 bits (826), Expect = 3e-86, Method: Composition-based stats.
Identities = 189/424 (44%), Positives = 263/424 (62%), Gaps = 30/424 (7%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFN 60
MS PF SAPGKVIIFGEHSAVY KPA+AA++S LR YLL++ S PDTI L FPDI+
Sbjct: 1 MSTPFFVSAPGKVIIFGEHSAVYGKPAIAAALS-LRAYLLVTPSQDPDTINLSFPDINLT 59
Query: 61 HKWSINDFNAITEDQV--NSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCF 118
H W+ ND I D + + + Q ++ L E+V L +LA L+ S HY A CF
Sbjct: 60 HSWNKND---IPWDSIVKHINLVDNLPQTSEELVPEIVDQLGSVLADLNSSLHYTACLCF 116
Query: 119 LYMFVCLCPHA-KNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLIGS------ND 171
LY++ LC + F ++STLPIGAGLGSSAS +V LA A+A LG + S +
Sbjct: 117 LYLYTHLCNQELAGMSFCIRSTLPIGAGLGSSASTAVCLASALAILGNRVTSASFLQTDK 176
Query: 172 LEKLSENDKHIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFL 231
+ K ND ++ W+ +GEKC HG PSGIDNAVAT+G A++F++ N + +
Sbjct: 177 ILKKENNDLDFIDSWSLMGEKCFHGNPSGIDNAVATHGGAVMFQR--MNNPAQPSVRTSM 234
Query: 232 DDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLS 291
+FPAI ++LT T++PRST DLV V L E +P+ IL+AM + +IM +
Sbjct: 235 RNFPAIKLLLTNTKVPRSTADLVGGVGKLNVE-YPKTSNSILEAMEHLSNTAYQIMVR-- 291
Query: 292 KCKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTG 351
G ++ ++L EL+ INHGLLV++GVSHP LE +K ++D ++GSTKLTG
Sbjct: 292 PFFGAEER---------KKLRELVNINHGLLVALGVSHPSLEKVKIITDTSKLGSTKLTG 342
Query: 352 AGGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLNKDLKIK 411
AGGGGC++TL+ D+++ I +L+ + YE FET LGG G LS +++ ++L +
Sbjct: 343 AGGGGCAITLVDEDVSEADIAQGIAELEKE-GYECFETSLGGKGVGSLSFEDVPQEL--R 399
Query: 412 SLVF 415
S VF
Sbjct: 400 STVF 403
>ref|XP_723495.1| mevalonate kinase [Candida albicans SC5314]
ref|XP_723305.1| mevalonate kinase [Candida albicans SC5314]
gb|EAL04601.1| hypothetical protein CaO19.12272 [Candida albicans SC5314]
gb|EAL04797.1| hypothetical protein CaO19.4809 [Candida albicans SC5314]
Length = 431
Score = 317 bits (812), Expect = 1e-84, Method: Composition-based stats.
Identities = 186/419 (44%), Positives = 253/419 (60%), Gaps = 33/419 (7%)
Query: 3 LPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFNHK 62
LPF+ APGKVIIFGEH+AVY KPA+AA++S LR YLL+S SS +TI L FPDI +H
Sbjct: 4 LPFIVGAPGKVIIFGEHAAVYGKPAIAAALS-LRCYLLVSPSSDSNTIRLQFPDIKLDHS 62
Query: 63 WSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLYMF 122
W+I D + A Q L E+V L L HY+A FCFLY+
Sbjct: 63 WNIKDLPWEEIKPYLTYDSANKPQIPSELVPEIVDKLSSFLNGFDNKMHYYACFCFLYLL 122
Query: 123 VCLC-PHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLIGSNDLEKLSENDK- 180
+ LC + F ++STLPIGAGLGSSAS SV L+ A+A +GG I L ENDK
Sbjct: 123 MNLCDSKVSGMNFIVRSTLPIGAGLGSSASTSVCLSSALALMGGWINK---PSLHENDKL 179
Query: 181 --------HIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDS--HNGTINTNNFKF 230
+++W+ IGEKC HG PSGIDNAVAT+G A++F++ S +I TN
Sbjct: 180 DTADIPDLEFIDKWSLIGEKCFHGNPSGIDNAVATFGGAVMFQRTSTPEQPSIRTN---- 235
Query: 231 LDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKL 290
+ +FPAI ++LT T++P+ST DLVA V L E F + IL A+ + + ++M +
Sbjct: 236 MRNFPAIKLLLTNTKVPKSTADLVAGVGRLNAE-FNSISTSILTAIEHLSQEAYKVM--M 292
Query: 291 SKCKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLT 350
+ G ++ V L +L+ INHGLLV++GVSHP LE +K + D RIG+TKLT
Sbjct: 293 NPMFGKEETNV---------LRKLVNINHGLLVALGVSHPALETVKIIGDKHRIGATKLT 343
Query: 351 GAGGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLNKDLK 409
GAGGGGC++TL+ D+ + I + K+ +D YE+FET LGG G +L ++L+ K
Sbjct: 344 GAGGGGCAITLVNDDVEESVIHNAIKEFEDS-GYESFETSLGGKGVGILFHEDLDDATK 401
>ref|XP_460851.1| hypothetical protein DEHA0F12188g [Debaryomyces hansenii CBS767]
emb|CAG89196.1| unnamed protein product [Debaryomyces hansenii CBS767]
Length = 433
Score = 313 bits (802), Expect = 2e-83, Method: Composition-based stats.
Identities = 183/414 (44%), Positives = 246/414 (59%), Gaps = 30/414 (7%)
Query: 4 PFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFNHKW 63
PFL SAPGKVII+GEHSAVY KPA+AA++S LR YLL++ + I LDFPDI +H W
Sbjct: 5 PFLVSAPGKVIIYGEHSAVYGKPAIAAALS-LRAYLLVTPCEDVNDIRLDFPDIGLSHSW 63
Query: 64 SINDFNAITEDQVNSQKLAKAQQA-TDGLSQELVSLLDPLLAQLSESFHYHAAFCFLYMF 122
N N ED + T+ L E+V LL +LA + HY A CFLY++
Sbjct: 64 --NKENIPWEDIRKFVTFKDEKPVVTEELVPEIVDLLSTVLADVESKLHYTACLCFLYLY 121
Query: 123 VCLC-PHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLIG------SNDLEKL 175
L ++F +KSTLPIGAGLGSSA +V LA A+A LG + + + K
Sbjct: 122 ANLSNKDVPGMRFIVKSTLPIGAGLGSSACTAVCLASALARLGKHVSAACHTSTEKVYKK 181
Query: 176 SENDKHIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDS--HNGTINTNNFKFLDD 233
+D ++ W+ +GEKC HG PSGIDNAVATYG A++F++ + ++ T + +
Sbjct: 182 ENSDLDFIDSWSLMGEKCFHGNPSGIDNAVATYGGAVMFQRTTIPSKPSVRTT----MRN 237
Query: 234 FPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSKC 293
FP I +IL T++PRST LV V V +P+ ILDAM + +IM + S
Sbjct: 238 FPPIKLILINTKVPRSTAALVGNV-AQVNRTYPKCAGSILDAMEHLVFEAYQIMIRPSFG 296
Query: 294 KGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGAG 353
K D QL EL+ INHGLLV++GVSHP LE IK + D IGSTKLTGAG
Sbjct: 297 KEEKD-----------QLRELVNINHGLLVALGVSHPALEKIKIIGDTHGIGSTKLTGAG 345
Query: 354 GGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLNKD 407
GGGC+++L+ D+ +E I K+ +++ YETFET LGG G LS ++++KD
Sbjct: 346 GGGCAISLVHDDVEEEVIQKAIKEFENE-GYETFETSLGGKGVGSLSLEDVDKD 398
>ref|XP_001527900.1| hypothetical protein LELG_00420 [Lodderomyces elongisporus NRRL
YB-4239]
gb|EDK42242.1| hypothetical protein LELG_00420 [Lodderomyces elongisporus NRRL
YB-4239]
Length = 439
Score = 295 bits (756), Expect = 4e-78, Method: Composition-based stats.
Identities = 174/412 (42%), Positives = 254/412 (61%), Gaps = 36/412 (8%)
Query: 2 SLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSA-PDTIELDFPDISFN 60
SL F+ SAPGKVIIFGEH+AVY KPA+AA++S LR +LL++ S+ + + L FPDI +
Sbjct: 8 SLKFVVSAPGKVIIFGEHAAVYGKPAIAAALS-LRCFLLVTPSTGDSNMVRLKFPDIGLD 66
Query: 61 HKWSINDFNAIT-EDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFL 119
H W I+ T + +V + K Q + L E+V L PLL L ++ HY A FCFL
Sbjct: 67 HSWDISSIPWETIKAKVKADSNGKPQPPAE-LDPEIVDSLSPLLRNLDDNVHYIACFCFL 125
Query: 120 YMFVCLCPH-AKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLIGSNDLEKLSEN 178
Y++ LC + F ++STLPIGAGLGSSAS +V L+ A++ LG I KLS +
Sbjct: 126 YLYTNLCSQDLQGYTFVVRSTLPIGAGLGSSASTAVCLSAALSKLGNWIKD---PKLSNH 182
Query: 179 DK---------HIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEK--DSHNGTINTNN 227
D ++ W+ IGEKC HG PSGIDNAVAT+G A+ +++ +S ++ ++
Sbjct: 183 DHVLESEIPELDFIDNWSLIGEKCFHGNPSGIDNAVATHGGAVKYQRILNSTKSSLRSS- 241
Query: 228 FKFLDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIM 287
+ DFP I ++LT T++P+ST LVA V L T++FP++ PIL+A+ + Q E+M
Sbjct: 242 ---IRDFPPIKLLLTNTKVPKSTAKLVAGVGEL-TKEFPDITNPILNAVEFISEQAYEVM 297
Query: 288 TKLSKCKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGST 347
+ + L +L+ +NHGLLV++GVSHP LE +K +SD +G+T
Sbjct: 298 -----------HLPQFGKQETATLRKLVNMNHGLLVALGVSHPALETVKIISDKYNLGAT 346
Query: 348 KLTGAGGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLL 399
KLTGAGGGGC++TL+ I + I + K+ +++ +E+FET LGG G +L
Sbjct: 347 KLTGAGGGGCAITLVDESIDKSVIHNAMKEYENE-GFESFETSLGGKGVGML 397
>ref|XP_001593159.1| hypothetical protein SS1G_06081 [Sclerotinia sclerotiorum 1980]
gb|EDO03600.1| hypothetical protein SS1G_06081 [Sclerotinia sclerotiorum 1980]
Length = 473
Score = 275 bits (704), Expect = 4e-72, Method: Composition-based stats.
Identities = 172/411 (41%), Positives = 248/411 (60%), Gaps = 30/411 (7%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISE-SSAPDTIELDFPDISF 59
M PF+ SAPGKVI+FGEH+ V+ KPA+AA++S LR+YLL++ S + TI L FPDI+
Sbjct: 26 MMPPFMVSAPGKVIVFGEHAVVHGKPAIAAAIS-LRSYLLVTALSKSKRTISLRFPDINL 84
Query: 60 NHKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLS-------ESFHY 112
+H W+I+D T + +K Q + L ELV+ + P L +S H
Sbjct: 85 SHTWNIDDLPWSTFSHPSKKKYYYDQVTS--LDPELVAAMKPHLENISPDESPSIRKIHQ 142
Query: 113 HAAFCFLYMFVCLCPHA-KNIKFSLKSTLPIGAGLGSSASISVSLALAMAY-LGGLIGSN 170
+A FLY+F+ L + ++L+ST+PIGAGLGSSASISV L+ A+ + L G +
Sbjct: 143 SSASSFLYIFLSLGSQSFPGCLYTLRSTIPIGAGLGSSASISVCLSSALLLQIRTLSGPH 202
Query: 171 DLEKLSENDKHI--VNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNF 228
+ +E + +N+WAF+GE CIHG PSG+DN V+T G A++++K T+
Sbjct: 203 PDQPSNEASLQLERINRWAFVGEMCIHGNPSGVDNTVSTQGKAVIYQKFPEGPTV----- 257
Query: 229 KFLDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMT 288
K L DFP +P++L T+ +ST VA+V +L EK P ++ ILDA ++++
Sbjct: 258 KPLRDFPELPLLLVDTQQAKSTAHEVAKVGLL-KEKHPAIVDSILDA--------IDMVG 308
Query: 289 KLSKCKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTK 348
+ + +D N E E L +L+ INHGLLVS+GVSHP LE I+ L D IG TK
Sbjct: 309 QSAAAMISDPNYDSENIECVESLGKLMTINHGLLVSLGVSHPRLERIRELVDHEGIGWTK 368
Query: 349 LTGAGGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLL 399
LTGAGGGGCS+TLL+ D T E++ + L+++ Y+ FET LG G +L
Sbjct: 369 LTGAGGGGCSITLLKPDTTPERMARLEATLENE-GYKKFETTLGCDGVGVL 418
>ref|XP_001483309.1| hypothetical protein PGUG_04038 [Pichia guilliermondii ATCC 6260]
gb|EDK39940.1| hypothetical protein PGUG_04038 [Pichia guilliermondii ATCC 6260]
Length = 423
Score = 275 bits (702), Expect = 7e-72, Method: Composition-based stats.
Identities = 169/414 (40%), Positives = 244/414 (58%), Gaps = 40/414 (9%)
Query: 4 PFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFNHKW 63
PF SAPGKVI+FGEH+AVY KPA+AA++S L + D++ L+FPDI +H W
Sbjct: 3 PFYISAPGKVILFGEHAAVYGKPALAAALSLRAYLLATETND--DSLRLEFPDIQLSHSW 60
Query: 64 SINDF---NAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLY 120
+++ NA Q + ++ TD L+ E+++L+ L + + HY CFLY
Sbjct: 61 KLSELPWENA----QAHIERKNGKPVPTDELNPEVINLIGEFLGDIESTAHYTTCLCFLY 116
Query: 121 MFVCLC-PHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLIGSNDLEKL---- 175
+++ LC P + F ++STLPIGAGLGSSAS +V L +A LGG I S +
Sbjct: 117 LYLHLCDPLVASRSFCIRSTLPIGAGLGSSASAAVCLTSTLALLGGHIRSPQYSEKQRVS 176
Query: 176 SEN-DKHIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEK--DSHNGTINTNNFKFLD 232
SEN D ++ W+ +GEKC HG PSGIDNAVAT+G A+++++ ++ T +
Sbjct: 177 SENPDAEFIDSWSLMGEKCFHGNPSGIDNAVATHGGAVMYQRMLAPDMPSVRTA----MR 232
Query: 233 DFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSK 292
+FP + ++LT T++PRST +LV V V + P+ ILDA+ A IM+ S
Sbjct: 233 NFPPLKLLLTNTKVPRSTAELVGGV-AKVNTRHPKTAGSILDAVSHLATDAYHIMSHPSF 291
Query: 293 CKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGA 352
E E L +L+ INHGLLV++GVSHP LE IK + D RIG+TKLTGA
Sbjct: 292 AA-----------EDRESLRQLVNINHGLLVALGVSHPALEKIKMIGDTNRIGATKLTGA 340
Query: 353 GGGGCSLTLLRRDITQEQIDSFKKKLQDDFS---YETFETDLGGTGCCLLSAKN 403
GGGGC++TLL +++ E ++ K++++F+ +ETFE LGG G L N
Sbjct: 341 GGGGCAITLLNDEVSHEVLE----KVENEFTQEGFETFEATLGGKGVGALFCDN 390
>ref|XP_001911734.1| unnamed protein product [Podospora anserina]
emb|CAP73562.1| unnamed protein product [Podospora anserina]
Length = 528
Score = 274 bits (701), Expect = 9e-72, Method: Composition-based stats.
Identities = 167/411 (40%), Positives = 250/411 (60%), Gaps = 28/411 (6%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISE-SSAPDTIELDFPDISF 59
M F+ SAPGKVI+FGEH+ V+ K A+AAS+ ALR+YLL++ S + T+ L FPDI F
Sbjct: 73 MMPSFMVSAPGKVIVFGEHAVVHGKAAIAASI-ALRSYLLVTSLSKSRKTVTLKFPDIDF 131
Query: 60 NHKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLS-------ESFHY 112
+H W I++ Q + +K + + QELV+ + P LA +S H
Sbjct: 132 DHSWRIDELPWAIFQQPSKKKYYYS--LVTEIDQELVAAIQPYLADVSPDKPADVRKVHQ 189
Query: 113 HAAFCFLYMFVCLCPHA-KNIKFSLKSTLPIGAGLGSSASISVSLALAMAY-LGGLIGSN 170
++A FLYMF+ L + +++L+ST+PIGAGLGSSA+I+V L+ A+ L L G +
Sbjct: 190 NSAGSFLYMFLSLGSQSFPACQYTLRSTIPIGAGLGSSATIAVCLSAALLLQLRTLSGPH 249
Query: 171 DLEKLSENDKHI--VNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNF 228
+ E I +N+WA++ E IHG PSG+DN V+T G A++F++ ++ +
Sbjct: 250 PDQPPEEARMQIERINRWAYVYEMFIHGNPSGVDNTVSTQGKAVMFQRTDYS---KAPDV 306
Query: 229 KFLDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMT 288
K L DFP +P++L TR P+ST VA+V L + P+++ ILDA+ + E++
Sbjct: 307 KPLWDFPELPLLLVDTRTPKSTAHEVAKVGRL-KDTHPKLVGSILDAIDKVTQTSAELIA 365
Query: 289 KLSKCKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTK 348
+ DD + E + L ++ EL+ INHGLLVS+GVSHP LE ++ L D IG TK
Sbjct: 366 E-------DDFSTEKEDSL-RRVGELMNINHGLLVSLGVSHPRLERVRELVDHQGIGWTK 417
Query: 349 LTGAGGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLL 399
LTGAGGGGCS+TLL+ + +E++ +++L D+ Y+ FET LGG G +L
Sbjct: 418 LTGAGGGGCSITLLKPGVPREKLARLEEQL-DEEGYQRFETTLGGDGVGVL 467
>ref|XP_001229023.1| hypothetical protein CHGG_02507 [Chaetomium globosum CBS 148.51]
gb|EAQ90572.1| hypothetical protein CHGG_02507 [Chaetomium globosum CBS 148.51]
Length = 532
Score = 269 bits (687), Expect = 4e-70, Method: Composition-based stats.
Identities = 166/412 (40%), Positives = 248/412 (60%), Gaps = 30/412 (7%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISE-SSAPDTIELDFPDISF 59
M F+ SAPGKVI+FGEHS V+ K A+AA++S LR+YLL++ S + T+ L FPDI F
Sbjct: 82 MMPAFMVSAPGKVIVFGEHSVVHGKAAIAAAIS-LRSYLLVTTLSKSKRTVTLKFPDIDF 140
Query: 60 NHKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLS-------ESFHY 112
+H W+I++ T Q + +K + L ELV+ + P LA +S H
Sbjct: 141 DHCWNIDELPWATFQQPSKKKYYYS--LVTELDPELVAAIQPFLANVSPDKPAGIRKVHQ 198
Query: 113 HAAFCFLYMFVCLCPHA-KNIKFSLKSTLPIGAGLGSSASISVSLALAMAY-LGGLIGSN 170
++A FLYMF+ L + +++L+ST+PIGAGLGSSA+I+V ++ A+ L L G +
Sbjct: 199 NSAGSFLYMFLSLGSQSFPGCQYTLRSTIPIGAGLGSSATIAVCMSAALLLQLRTLAGPH 258
Query: 171 DLEKLSENDKHI--VNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNF 228
+ E I +N+WA++ E IHG PSG+DN VAT G A++F++ + +
Sbjct: 259 PDQPADEARMQIERINRWAYVYEMFIHGNPSGVDNTVATQGKAVVFQRTDYG---KPPSV 315
Query: 229 KFLDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMT 288
+ L DFP +P++L TR+P+ST VA+V L P ++ ILDAM + A E++T
Sbjct: 316 RPLWDFPELPLLLVDTRVPKSTAHEVAKVGKL-KNTHPVLVGSILDAMDKVADASAEVLT 374
Query: 289 KLSKCKGTDDEAVETNNEL-YEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGST 347
+E +T +E ++ EL+ +NHGLLVS+GVSHP LE ++ L D IG T
Sbjct: 375 ---------EEGFDTQSEASLARVGELMTVNHGLLVSLGVSHPRLERVRELVDHEGIGWT 425
Query: 348 KLTGAGGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLL 399
KLTGAGGGGC +TLL+ + ++++ + +L D+ +E FET LGG G +L
Sbjct: 426 KLTGAGGGGCCITLLKPGVERKKLRKLQAQL-DEEGFEKFETTLGGDGVGVL 476
>ref|XP_961360.1| hypothetical protein NCU03633 [Neurospora crassa OR74A]
emb|CAC28692.1| related to MEVALONATE KINASE [Neurospora crassa]
gb|EAA32124.1| hypothetical protein NCU03633 [Neurospora crassa OR74A]
Length = 528
Score = 268 bits (685), Expect = 7e-70, Method: Composition-based stats.
Identities = 165/407 (40%), Positives = 246/407 (60%), Gaps = 28/407 (6%)
Query: 5 FLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISE-SSAPDTIELDFPDISFNHKW 63
F+ SAPGKVI+FGEH+ V+ K A+AA++S LR+YLL++ S + T+ L FPDI FNH W
Sbjct: 80 FMVSAPGKVIVFGEHAVVHGKAAIAAAIS-LRSYLLVNTLSKSKRTVTLKFPDIDFNHSW 138
Query: 64 SINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLS-------ESFHYHAAF 116
+I++ Q +K + + QELV + P LA +S H ++A
Sbjct: 139 NIDELPWKIFQQPGKKKYYYS--LVTEIDQELVDAVQPFLADVSIDKPADIRKVHQNSAG 196
Query: 117 CFLYMFVCLCPHA-KNIKFSLKSTLPIGAGLGSSASISVSLALAMAY-LGGLIGSNDLEK 174
FLYMF+ L + +++L+ST+PIGAGLGSSA+I+V L+ A+ L L G + +
Sbjct: 197 SFLYMFLSLGSQSFPGCQYTLRSTIPIGAGLGSSATIAVCLSAALLLQLRTLSGPHPDQP 256
Query: 175 LSENDKHI--VNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLD 232
E I +N+WAF+ E IHG PSG+DN V+T G A++F++ +N + + L
Sbjct: 257 PEEARLQIERINRWAFVYEMFIHGNPSGVDNTVSTQGKAVVFQRTDYN---QPPSVRPLW 313
Query: 233 DFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSK 292
DFP +P++L TR +ST VA+V L +K P+++ IL A+ + +++ + +
Sbjct: 314 DFPKLPLLLVDTRTAKSTAHEVAKVATL-KKKHPQLVGTILTAIDQVTQSSAQLIEE--Q 370
Query: 293 CKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGA 352
T+DE E ++ E++ INHGLLVS+GVSHP LE ++ L D IG TKLTGA
Sbjct: 371 GFNTEDE------ESLSKVGEMMTINHGLLVSLGVSHPRLERVRELVDHEGIGWTKLTGA 424
Query: 353 GGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLL 399
GGGGCS+TLLR + +E++D +++L D+ Y FET LG G +L
Sbjct: 425 GGGGCSITLLRPGVPREKLDKLEQRL-DEEGYSKFETTLGSDGVGVL 470
>ref|XP_386088.1| hypothetical protein FG05912.1 [Gibberella zeae PH-1]
Length = 508
Score = 266 bits (681), Expect = 2e-69, Method: Composition-based stats.
Identities = 169/411 (41%), Positives = 247/411 (60%), Gaps = 28/411 (6%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISE-SSAPDTIELDFPDISF 59
M+ PF+ SAPGKVI+FGEHS V+ K A+AA++S LR+YL ++ S + T+ L F DI
Sbjct: 57 MAPPFMVSAPGKVIVFGEHSVVHGKAAIAAAIS-LRSYLHVTTLSKSKRTVSLRFADIGL 115
Query: 60 NHKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSES-------FHY 112
H W+I D Q S+K + T+ L +LV+ + P + +S + H+
Sbjct: 116 VHTWNIEDL-PWEAFQQPSKKKSYYSLVTE-LDPDLVAAIQPHIEVVSPNHPEEIRRVHH 173
Query: 113 HAAFCFLYMFVCL-CPHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMAY-LGGLIGSN 170
+ FLY+F+ L P ++L+ST+PIGAGLGSSAS+SV LA A+ L L G +
Sbjct: 174 SSVSAFLYLFLSLGSPSFPPCLYTLRSTIPIGAGLGSSASVSVCLASALLLQLRTLSGPH 233
Query: 171 DLEKLSENDKHI--VNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNF 228
+ E + +N+WAF+ E CIHG PSG+DN VAT G A++F++ ++ N
Sbjct: 234 PDQPADEARLQVERINRWAFVSEMCIHGNPSGVDNTVATQGKAVVFQRTDYS---KPPNV 290
Query: 229 KFLDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMT 288
+ L DFP +P++L TR +ST VA+V L + P+++ ILDAM + E++
Sbjct: 291 RPLWDFPELPLLLVDTRQAKSTAHEVAKVAKL-KQTHPKLVNSILDAMDKVTDAASELIE 349
Query: 289 KLSKCKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTK 348
+ S D+ +VE ++ EL+ INHGLLVS+GVSHP LE ++ L D IG TK
Sbjct: 350 ETS----FDNGSVED----LSKVGELMTINHGLLVSLGVSHPRLERVRELVDHEGIGWTK 401
Query: 349 LTGAGGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLL 399
LTGAGGGGCS+TLLR D+ E++ +++L+ + +Y FET LGG G +L
Sbjct: 402 LTGAGGGGCSITLLRPDVPAEKLQKLEERLETE-NYAKFETTLGGDGIGVL 451
>ref|XP_001559870.1| hypothetical protein BC1G_01429 [Botryotinia fuckeliana B05.10]
gb|EDN27159.1| hypothetical protein BC1G_01429 [Botryotinia fuckeliana B05.10]
Length = 498
Score = 264 bits (674), Expect = 1e-68, Method: Composition-based stats.
Identities = 166/411 (40%), Positives = 245/411 (59%), Gaps = 30/411 (7%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISE-SSAPDTIELDFPDISF 59
M PF+ SAPGKVI+FGEH+ V+ KPA+AA++S LR+YLL++ S + TI L FPDI+
Sbjct: 50 MMPPFMVSAPGKVIVFGEHAVVHGKPAIAAAIS-LRSYLLVTSLSKSKRTISLRFPDINL 108
Query: 60 NHKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLS-------ESFHY 112
+H W+I+D T + +K L ELV+ + P L +S H
Sbjct: 109 SHTWNIDDLPWSTFSHPSKKK--HYYDEVTSLDPELVAAMKPHLENISPDESPAIRKIHQ 166
Query: 113 HAAFCFLYMFVCLCPHA-KNIKFSLKSTLPIGAGLGSSASISVSLALAMAY-LGGLIGSN 170
+A FLY+F+ L + ++L+ST+PIGAGLGSSASISV L+ A+ + L G +
Sbjct: 167 SSASSFLYIFLSLGSQSFPGCLYTLRSTIPIGAGLGSSASISVCLSSALLLQIRTLSGPH 226
Query: 171 DLEKLSENDKHI--VNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNF 228
+ +E + +N+WAF+GE CIHG PSG+DN V+T G A++++K T+
Sbjct: 227 PDQPSNEASLQLERINRWAFVGEMCIHGNPSGVDNTVSTQGKAVIYQKSPDGPTV----- 281
Query: 229 KFLDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMT 288
K L +FP +P++L T+ +ST VA+V +L +K P ++ IL+A+ + Q +M
Sbjct: 282 KPLRNFPELPLLLVDTQQAKSTAHEVAKVDLL-KQKHPAIVDSILNAI-DMVGQSAAVMI 339
Query: 289 KLSKCKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTK 348
+D E + + E L +L+ +NHGLLVS+GVSHP LE I+ L D IG TK
Sbjct: 340 -------SDPEYDSEDLKCVEDLGKLMTVNHGLLVSLGVSHPRLERIRELVDHEGIGWTK 392
Query: 349 LTGAGGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLL 399
LTGAGGGGCS+TLL+ T +++ ++ L+ + Y+ FET LG G +L
Sbjct: 393 LTGAGGGGCSITLLKPGTTHDRMTRLEETLETE-GYKKFETTLGCDGVGVL 442
>ref|XP_001214601.1| conserved hypothetical protein [Aspergillus terreus NIH2624]
gb|EAU34492.1| conserved hypothetical protein [Aspergillus terreus NIH2624]
Length = 541
Score = 261 bits (667), Expect = 9e-68, Method: Composition-based stats.
Identities = 162/407 (39%), Positives = 233/407 (57%), Gaps = 28/407 (6%)
Query: 5 FLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISE-SSAPDTIELDFPDISFNHKW 63
F+ SAPGKVI+FGEH+ V+ K A+AA++S LR+YLL++ + + T+ L+F DI H W
Sbjct: 96 FMVSAPGKVIVFGEHAVVHGKAAMAAAIS-LRSYLLVTTLTKSQRTVTLNFRDIGLAHTW 154
Query: 64 SINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLS-------ESFHYHAAF 116
+I+D Q +K L ELV + P + Q+S H +A
Sbjct: 155 NIDDLPWDVFHQPAKKKYY--YDLVTSLDPELVDAIQPYVDQVSPDLPEDQRKIHRRSAS 212
Query: 117 CFLYMFVCL-CPHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMAY-LGGLIGSNDLEK 174
FLY+ + L P ++L+ST+PIGAGLGSSAS+ V L+ A+ + L G + +
Sbjct: 213 AFLYLLLSLGSPQHPGAIYTLRSTIPIGAGLGSSASVCVCLSAALLLQIRTLAGPHPDQP 272
Query: 175 LSENDKHI--VNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLD 232
E + I +N+WAF+GE C HG PSG+DN V+ G A++F + ++ + + L
Sbjct: 273 PDEAEVQIERINRWAFVGEMCTHGNPSGVDNTVSAGGKAVIFRRTDYS---KPPSVRSLP 329
Query: 233 DFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSK 292
FP +P++L TR PRST VA+V L E+ P V + ILDA+ + L E++ K
Sbjct: 330 TFPELPLLLVDTRQPRSTAVEVAKVGKL-KEEHPVVTESILDAIDKLTLSAEELLDGCEK 388
Query: 293 CKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGA 352
T+ E+ E+L L+RINHG LVS+GVSHP LE I+ L D IG TKLTGA
Sbjct: 389 TGVTE--------EVLERLGTLVRINHGFLVSLGVSHPRLERIRELVDFANIGWTKLTGA 440
Query: 353 GGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLL 399
GGGGC++TLLR D + + + KL + + +ET LGG G +L
Sbjct: 441 GGGGCAITLLRPDADKNAVRDLEAKLAAE-GFAKYETTLGGDGIGVL 486
>ref|XP_500956.1| hypothetical protein [Yarrowia lipolytica]
emb|CAG83209.1| unnamed protein product [Yarrowia lipolytica CLIB122]
Length = 449
Score = 260 bits (665), Expect = 1e-67, Method: Composition-based stats.
Identities = 169/437 (38%), Positives = 254/437 (58%), Gaps = 56/437 (12%)
Query: 3 LPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIE-LDFPDISFNH 61
+ ++ SAPGKVI+FGEH+AV+ KPA+AA++ LRTYLL+ +++ L+FPDI N
Sbjct: 1 MDYIISAPGKVILFGEHAAVFGKPAIAAAID-LRTYLLVETTTSDTPTVTLEFPDIHLNF 59
Query: 62 KWSINDFNAITE----DQVN-SQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAF 116
K ++ ++T D +N S + D LS L L +P L ++ ++ A
Sbjct: 60 KVQVDKLASLTAQTKADHLNWSTPKTLDKHIFDSLSS-LALLEEPGLTKVQQA----AVV 114
Query: 117 CFLYMFVCLCPHA---KNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLIG---SN 170
FLY+++ LCP + + + ++STLPIGAGLGSSASI V LA + L G + +
Sbjct: 115 SFLYLYIHLCPPSVCEDSSNWVVRSTLPIGAGLGSSASICVCLAAGLLVLNGQLSIDQAR 174
Query: 171 DLEKLSENDKHIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKF 230
D + L+E +V+ W+F+GE CIHG PSGIDNAVAT G ALLF++ NN
Sbjct: 175 DFKSLTEKQLSLVDDWSFVGEMCIHGNPSGIDNAVATQGGALLFQR--------PNNRVP 226
Query: 231 LDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKL 290
L D P + ++LT T+ PRST DLV V VL T++F +M PI+ ++GE + Q +EI+++
Sbjct: 227 LVDIPEMKLLLTNTKHPRSTADLVGGVGVL-TKEFGSIMDPIMTSVGEISNQAMEIISRG 285
Query: 291 SK----------------------CKGTDDEA-VETNNELYEQLLELIRINHGLLVSIGV 327
K C +D A ++ ++ ++ L+RINHGLL+++GV
Sbjct: 286 KKMVDQSNLEIEQGILPQPTSEDACNVMEDGATLQKLRDIGSEMQHLVRINHGLLIAMGV 345
Query: 328 SHPGLELIKNLSDDLRIGSTKLTGAGGGGCSLTLL-RRDITQEQIDSFKKKLQDDFS--- 383
SHP LE+I+ S +G TKLTGAGGGGC++TL+ +D T Q++ ++ +
Sbjct: 346 SHPKLEIIRTASIVHNLGETKLTGAGGGGCAITLVTSKDKTATQLEENVIAFTEEMATHG 405
Query: 384 YETFETDLG--GTGCCL 398
+E ET +G G G C+
Sbjct: 406 FEVHETTIGARGVGMCI 422
>ref|XP_001271672.1| mevalonate kinase [Aspergillus clavatus NRRL 1]
gb|EAW10246.1| mevalonate kinase [Aspergillus clavatus NRRL 1]
Length = 536
Score = 260 bits (665), Expect = 1e-67, Method: Composition-based stats.
Identities = 160/411 (38%), Positives = 237/411 (57%), Gaps = 28/411 (6%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISE-SSAPDTIELDFPDISF 59
M+ F+ SAPGKVI++GEH+ V+ K A+AA++S LR+YLL++ S + T+ ++F DI
Sbjct: 85 MAPAFMVSAPGKVIVYGEHAVVHGKAAMAAAIS-LRSYLLVTTLSKSQRTVTMNFRDIGL 143
Query: 60 NHKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLS-------ESFHY 112
+H W+I+D + +K L ELV + P + +S H
Sbjct: 144 DHTWNIDDLPWDVFHHPSKKKFY--YNLVTSLDPELVDAIQPHVDAVSPDKPEDVRKIHR 201
Query: 113 HAAFCFLYMFVCL-CPHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMAY-LGGLIGSN 170
+A FLY+F+ L P ++L+ST+PIGAGLGSSAS+ V L+ A+ + L G +
Sbjct: 202 RSASAFLYLFLSLGSPQTPGAIYTLRSTIPIGAGLGSSASVCVCLSAALLLQIRTLAGPH 261
Query: 171 DLEKLSENDKHI--VNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNF 228
+ E + I +N+WAF+GE C HG PSG+DN V+ G A++F ++ +
Sbjct: 262 PDQPPDEAETQIERINRWAFVGEMCTHGNPSGVDNTVSAGGKAVIFRREDYT---KPPTV 318
Query: 229 KFLDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMT 288
L +FP +P++L TR RST VA+V L + P V + ILDA+ + L E +
Sbjct: 319 IPLPNFPELPLLLVDTRQARSTAAEVAKVGKL-KDDHPVVTEAILDAIDKVTLAAQEAIQ 377
Query: 289 KLSKCKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTK 348
++ KG + ++ E L LIRINHG LVS+GVSHP LE I+ L D IG TK
Sbjct: 378 DINS-KGV-------SAQILEHLGTLIRINHGFLVSLGVSHPRLERIRELVDYANIGWTK 429
Query: 349 LTGAGGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLL 399
LTGAGGGGC++T+LR D+ +E + ++KL + +E +ET LGG G +L
Sbjct: 430 LTGAGGGGCAITVLRPDVKEEAVRDLEQKLSVE-GFEKYETTLGGDGIGVL 479
>ref|XP_001401587.1| hypothetical protein An04g02190 [Aspergillus niger]
emb|CAL00706.1| unnamed protein product [Aspergillus niger]
Length = 448
Score = 260 bits (665), Expect = 2e-67, Method: Composition-based stats.
Identities = 160/411 (38%), Positives = 239/411 (58%), Gaps = 28/411 (6%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISE-SSAPDTIELDFPDISF 59
M+ PF+ SAPGKVI+FGEH+ V+ K A+AA++S LR+Y L++ S + TI L+ D+ F
Sbjct: 1 MAPPFMVSAPGKVIVFGEHAVVHGKAAMAAAIS-LRSYFLVTTLSKSQRTITLNLRDMDF 59
Query: 60 NHKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLS-------ESFHY 112
NH W+I+D Q + +K L +EL L P + +S H
Sbjct: 60 NHTWNIDDLPWDFFKQPSKKKYY--YDLVTSLDEELYDSLKPCVEDISPKAPEEIRKKHK 117
Query: 113 HAAFCFLYMFVCL-CPHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMAY-LGGLIGSN 170
+A FLY+F L P ++L+ST+P+GAGLGSSAS+ + A+ + L G +
Sbjct: 118 GSALAFLYLFCSLGSPQHPGAIYTLRSTIPMGAGLGSSASVCTCFSAALLLQIRTLAGPH 177
Query: 171 DLEKLSENDKHI--VNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNF 228
D + E + I +N+WAF+GE CIHG PSG+DN V+T G A++F ++ ++
Sbjct: 178 DDQPPDEAELQIERINRWAFVGELCIHGNPSGVDNTVSTGGKAVIFRREDYS---KPPKV 234
Query: 229 KFLDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMT 288
L +FP +P++L TR RST VA+V L E P V + ILDA+ + + +
Sbjct: 235 IPLPNFPELPLLLVDTRQSRSTAVEVAKVGKLKKEH-PLVTESILDAIDKVTV------S 287
Query: 289 KLSKCKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTK 348
S +G + ++++ E E + L+R+NHG LVS+GVSHP LE I+ L D IG TK
Sbjct: 288 AQSAIQGVEGDSID--KETLEHIGTLVRVNHGFLVSLGVSHPRLERIRELVDFANIGWTK 345
Query: 349 LTGAGGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLL 399
LTGAGGGGC++TLLR D + + + ++KL + ++ +ET LGG G +L
Sbjct: 346 LTGAGGGGCAITLLRPDASVDALRELERKLAAE-NFSKYETTLGGDGIGVL 395
>ref|XP_001821298.1| hypothetical protein [Aspergillus oryzae RIB40]
dbj|BAE59296.1| unnamed protein product [Aspergillus oryzae]
Length = 534
Score = 259 bits (661), Expect = 4e-67, Method: Composition-based stats.
Identities = 167/411 (40%), Positives = 239/411 (58%), Gaps = 28/411 (6%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISE-SSAPDTIELDFPDISF 59
M+ F+ SAPGKVI+FGEH+ V+ K A+AA++S LR+YLL++ + + TI L+F DI
Sbjct: 86 MAPAFMVSAPGKVIVFGEHAVVHGKAAMAAAIS-LRSYLLVTTLTKSQRTITLNFRDIGL 144
Query: 60 NHKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLS----ESFHYH-- 113
NH WSI++ Q +K + EL+ + PL+ ++S E H
Sbjct: 145 NHTWSIDELPWDLFHQPTKKKYY--YDLVTSIDPELLDAILPLVERISPDLPEDKRKHQR 202
Query: 114 -AAFCFLYMFVCL-CPHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMAY-LGGLIGSN 170
AA FLY+F L P ++L+ST+P GAGLGSSASI V ++ A+ + L G +
Sbjct: 203 GAATAFLYLFCALGSPQHPGAIYTLRSTIPTGAGLGSSASICVCISAALLLQIRTLAGPH 262
Query: 171 DLEKLSENDKHI--VNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNF 228
+ E + I +N+WAF+GE CIHG PSG+DN VA G A++F + ++ ++
Sbjct: 263 PDQPPDEAEVQIERINRWAFVGEMCIHGNPSGVDNTVAAGGKAVIFRRGDYSKPPAVSS- 321
Query: 229 KFLDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMT 288
L +FP +P++L TR RST VA+V L E+ P V + ILD + + EI+
Sbjct: 322 --LPNFPELPLLLVDTRQSRSTAVEVAKVGQLKEEQ-PLVTEAILDTIEKVNASAQEII- 377
Query: 289 KLSKCKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTK 348
+ TD + + + E++ LIRINHGLLVS+GVSHP LE I+ L D IG TK
Sbjct: 378 -----RETDSSGI--SKDTLERIGALIRINHGLLVSLGVSHPRLERIRELVDFANIGWTK 430
Query: 349 LTGAGGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLL 399
LTGAGGGGC++TLLR D I ++KL D+ + +ET LGG G +L
Sbjct: 431 LTGAGGGGCAITLLRPDADPSAIRQLEEKL-DEEGFAKYETTLGGDGVGVL 480
>ref|XP_661473.1| hypothetical protein AN3869.2 [Aspergillus nidulans FGSC A4]
gb|EAA59134.1| hypothetical protein AN3869.2 [Aspergillus nidulans FGSC A4]
Length = 735
Score = 258 bits (659), Expect = 7e-67, Method: Composition-based stats.
Identities = 160/407 (39%), Positives = 238/407 (58%), Gaps = 28/407 (6%)
Query: 5 FLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISE-SSAPDTIELDFPDISFNHKW 63
F+ SAPGKVI++GEH+ V+ K A+AA++S LR+YLL++ S + TI L+F D + NH W
Sbjct: 291 FMVSAPGKVIVYGEHAVVHGKAAMAAAIS-LRSYLLVTTLSKSQRTITLNFRDTNLNHTW 349
Query: 64 SINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLS-------ESFHYHAAF 116
I+ + +K T L QEL + P + +S H +A
Sbjct: 350 DIDQLPWDLFHHPSKKKYYYDLVTT--LDQELYDAIQPHVEDISPDAPEEMRKIHKRSAS 407
Query: 117 CFLYMFVCL-CPHAKNIKFSLKSTLPIGAGLGSSASISVSLALAM-AYLGGLIGSNDLEK 174
FLY+F+ L P + ++L+ST+PIGAGLGSSAS+ V ++ A+ + L G + +
Sbjct: 408 AFLYLFLSLGSPQSAGAIYTLRSTIPIGAGLGSSASVCVCMSAALLVQIRTLAGPHPDQP 467
Query: 175 LSENDKHI--VNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLD 232
E + I +N+WAF+GE CIHG PSG+DN V+ G A++F + ++ + + L
Sbjct: 468 PDEAEVQIERINRWAFVGEMCIHGNPSGVDNTVSAGGKAVIFRRGDYSKPPSVTS---LP 524
Query: 233 DFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSK 292
FP +P++L TR RST VA+V L E +P V + ILDA+ +++ + +
Sbjct: 525 TFPELPLLLVDTRQGRSTAVEVAKVGALRKE-WPVVTESILDAIDNVTASAEKVIREPNP 583
Query: 293 CKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGA 352
+G ++ ++ QL LIRINHG LVS+GVSHP LE I+ L D IG TKLTGA
Sbjct: 584 -EGLSEKTLQ-------QLGTLIRINHGFLVSLGVSHPRLERIRELVDYADIGWTKLTGA 635
Query: 353 GGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLL 399
GGGGC++TLLR D+ + + K +LQD+ ++ +ET LGG G +L
Sbjct: 636 GGGGCAITLLRPDLNDDSLRQLKSQLQDE-NFGIYETTLGGDGVGVL 681
>ref|XP_370449.1| hypothetical protein MGG_06946 [Magnaporthe grisea 70-15]
gb|EDJ98120.1| hypothetical protein MGG_06946 [Magnaporthe grisea 70-15]
Length = 494
Score = 256 bits (655), Expect = 2e-66, Method: Composition-based stats.
Identities = 159/394 (40%), Positives = 235/394 (59%), Gaps = 29/394 (7%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISE-SSAPDTIELDFPDISF 59
M F+ SAPGKVI+FGEHS VY K AVAA+++ LR+YLL++ S + TI L FPDI
Sbjct: 43 MMPAFMVSAPGKVIVFGEHSVVYGKKAVAAAIN-LRSYLLVTALSKSKRTITLRFPDIDL 101
Query: 60 NHKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLS-------ESFHY 112
H W+I+D T Q + +K L +L+ + P L +S H
Sbjct: 102 IHTWNIDDLPWSTFSQPSKKKYY--YDLVTSLDPDLMDAIQPHLEPVSSDAPDAQRKVHM 159
Query: 113 HAAFCFLYMFVCLCPHA-KNIKFSLKSTLPIGAGLGSSASISVSLALAMAY-LGGLIGSN 170
AA FLY+F+ L HA ++L+ST+PIGAGLGSSASIS L+ A+ + L G +
Sbjct: 160 SAAAAFLYLFMSLGSHAFPGGIYTLRSTIPIGAGLGSSASISACLSAALLLQIRTLSGPH 219
Query: 171 DLEKLSENDKHI--VNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEK-DSHNGTINTNN 227
+ E + +N+WAF+ E CIHG PSG+DN V+T G A++F++ D + T
Sbjct: 220 PDQPPDEARVQVERINRWAFVAEMCIHGNPSGVDNTVSTQGKAVVFQRLDYARPPVVTPM 279
Query: 228 FKFLDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIM 287
+ DFP +P+++ T+ +STK V +V L E P+++ ILD+M + +++
Sbjct: 280 W----DFPELPLLVVDTKQAKSTKYEVEKVAKL-RETHPKIVNSILDSMDKLTQAATDVL 334
Query: 288 TKLSKCKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGST 347
T + D+E VE+ +++ EL+ +NHGLLVS+GVSHP LE ++ L D IG T
Sbjct: 335 TD----EDFDNEDVES----LQKVGELMGMNHGLLVSLGVSHPRLERVRELVDHEGIGWT 386
Query: 348 KLTGAGGGGCSLTLLRRDITQEQIDSFKKKLQDD 381
KLTGAGGGGCS+TL+R D+ +E+++ K++L +
Sbjct: 387 KLTGAGGGGCSITLMRPDVPREKLERLKERLDHE 420
>gb|EEH48028.1| mevalonate kinase [Paracoccidioides brasiliensis Pb18]
Length = 490
Score = 255 bits (652), Expect = 4e-66, Method: Composition-based stats.
Identities = 160/411 (38%), Positives = 237/411 (57%), Gaps = 28/411 (6%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISE-SSAPDTIELDFPDISF 59
M+ F+ SAPGKVI+FGEH+ V+ K A+AA++S LR+YLL++ S + TI L+F DI
Sbjct: 38 MAPAFMVSAPGKVIVFGEHAVVHGKRAMAAAIS-LRSYLLVTTLSKSQRTITLNFRDIEL 96
Query: 60 NHKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLS-------ESFHY 112
+H W+I+ Q + +K + L EL+ + P +A +S H
Sbjct: 97 DHTWNIDSLPWALFCQPSKKKFY--YDSVTSLDPELLEAIQPHIADISIGKPDEVRKIHR 154
Query: 113 HAAFCFLYMFVCLC-PHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMAY-LGGLIGSN 170
+A FLY+F+ L P + ++L+ST+PIGAGLGSSASI+V L+ A+ + L G +
Sbjct: 155 SSATAFLYLFLSLSSPDSHAAIYTLRSTIPIGAGLGSSASIAVCLSAALLLQIRILAGPH 214
Query: 171 DLEKLSENDKHI--VNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNF 228
+ E + I +N+WAF+GE CIHG PSG+DN V+ G A++F + ++ +
Sbjct: 215 QDQPPEEAEVQIERINRWAFVGEMCIHGNPSGVDNTVSAGGKAVIFRRGDYSKPPSVTP- 273
Query: 229 KFLDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMT 288
+ DFP +P++L +R PRST VA+V +F + A+ E L ++ +T
Sbjct: 274 --ILDFPELPLLLVNSRQPRSTATEVAKV-----GRFCKAHP----AVAESTLAAIDQVT 322
Query: 289 KLSKCKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTK 348
+ + + +NE + EL RINHGLLVS+GVSHP LE I+ L D IG TK
Sbjct: 323 ESANNFIQSGRFDKDSNEDIDHFGELFRINHGLLVSLGVSHPRLERIRELVDHAGIGWTK 382
Query: 349 LTGAGGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLL 399
LTGAGGGGC++ LLR + Q + ++ L DD +E +ET LGG G +L
Sbjct: 383 LTGAGGGGCAIVLLRANTNQAVLHHLEQNL-DDEGFERYETTLGGNGIGVL 432
>ref|XP_001241830.1| hypothetical protein CIMG_05726 [Coccidioides immitis RS]
gb|EAS30247.1| hypothetical protein CIMG_05726 [Coccidioides immitis RS]
Length = 612
Score = 253 bits (647), Expect = 2e-65, Method: Composition-based stats.
Identities = 156/412 (37%), Positives = 237/412 (57%), Gaps = 30/412 (7%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISE-SSAPDTIELDFPDISF 59
M+ PF+ SAPGKVI+FGEH+ V+ K A+AA++S LR+YLL++ S + T+ L+F D
Sbjct: 163 MAPPFMVSAPGKVIVFGEHAVVHGKKAMAAAIS-LRSYLLVTTLSKSRRTVTLNFRDTGL 221
Query: 60 NHKWSINDFNAITEDQVN-SQKLAKAQQATDGLSQELVSLLDPLLAQLS-------ESFH 111
+H W D +++ D N S K L +L+ + P ++ +S H
Sbjct: 222 DHTW---DIDSLPWDVFNHSSKKKFYYDRVTSLDPDLLDAIRPHISNVSPDKPPEVRKVH 278
Query: 112 YHAAFCFLYMFVCL-CPHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMAY-LGGLIGS 169
+A FLY+++ L P + ++L+ST+PIGAGLGSSAS+ V L+ A+ + L G
Sbjct: 279 QGSASAFLYLYLSLGSPQSHGAIYTLRSTIPIGAGLGSSASVCVCLSAALLLQIRALAGP 338
Query: 170 NDLEKLSENDKHI--VNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNN 227
+ + E++ I +N+WAF+GE CIHG PSG+DN V+ G A++F + ++
Sbjct: 339 HPDQPFDESEVQIERINRWAFVGELCIHGNPSGVDNTVSAGGKAVIFRRGDYS---KPPT 395
Query: 228 FKFLDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIM 287
+ DFP +P++L +R RST VA+V L K + A+ +C L G++ +
Sbjct: 396 VIPILDFPELPLLLVNSRQSRSTATEVAKVGTL---------KKLHPAITDCLLDGIDQV 446
Query: 288 TKLSKCKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGST 347
T + + + + ++E L RINHGLLVS+GVSHP LE I+ L D IG T
Sbjct: 447 TTSAHDFISSENFDKNSSETLNYFGTLFRINHGLLVSLGVSHPRLERIRELVDHTGIGWT 506
Query: 348 KLTGAGGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLL 399
KLTGAGGGGC++TL+R D + +++L D+ YE +ET LGG G +L
Sbjct: 507 KLTGAGGGGCAITLIRTDRESTALKPLERQL-DEEGYERYETTLGGQGVGVL 557
>gb|EDP50156.1| mevalonate kinase [Aspergillus fumigatus A1163]
Length = 538
Score = 250 bits (638), Expect = 2e-64, Method: Composition-based stats.
Identities = 160/414 (38%), Positives = 236/414 (57%), Gaps = 34/414 (8%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISE-SSAPDTIELDFPDISF 59
M+ F+ SAPGKVI++GEH+ V+ K A+AA++S LR+YLL++ S + TI ++F DI
Sbjct: 88 MAPAFMVSAPGKVIVYGEHAVVHGKAAMAAAIS-LRSYLLVTTLSKSQRTITMNFRDIGL 146
Query: 60 NHKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLS-------ESFHY 112
+H W+I++ + +K L ELV+ + P +S H
Sbjct: 147 DHTWNIDELPWDVFHHPSKKKFY--YDLVTSLDPELVAAIQPHADAVSPDKPEDVRKIHR 204
Query: 113 HAAFCFLYMFVCL-CPHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMAY-LGGLIGSN 170
+A FLY+F+ L ++L+ST+PIGAGLGSSAS+ V L+ A+ + L G +
Sbjct: 205 RSASAFLYLFLSLGSSQNPGAIYTLRSTIPIGAGLGSSASVCVCLSAALLLQIRTLAGPH 264
Query: 171 DLEKLSENDKHI--VNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNF 228
+ E + I +N+WAF+GE C HG PSG+DN V+ G A++F ++ ++
Sbjct: 265 PDQPPDEAEVQIERINRWAFVGEMCTHGNPSGVDNTVSAGGKAVVFRREDYSKPPTVTP- 323
Query: 229 KFLDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMT 288
L +FP +P++L TR RST VA+V L +++P V IL+A+ + L + +
Sbjct: 324 --LLNFPELPLLLVDTRQSRSTAVEVAKVGKL-KDEYPVVTDSILEAIDQVTLAAQQKIQ 380
Query: 289 KLSKCKGTDDEAVETNNELY---EQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIG 345
++S TN Y E L LIRINHG LVS+GVSHP LE I+ L D IG
Sbjct: 381 EIS-----------TNGISYRTLEDLGTLIRINHGFLVSLGVSHPRLERIRELVDYADIG 429
Query: 346 STKLTGAGGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLL 399
TKLTGAGGGGC++TLLR DI +E + ++KL + + +ET LGG G +L
Sbjct: 430 WTKLTGAGGGGCAITLLRPDIKEEAVRELEEKLSAE-GFVKYETTLGGDGIGVL 482
>ref|XP_752047.1| mevalonate kinase [Aspergillus fumigatus Af293]
gb|EAL90009.1| mevalonate kinase [Aspergillus fumigatus Af293]
Length = 538
Score = 249 bits (635), Expect = 4e-64, Method: Composition-based stats.
Identities = 161/414 (38%), Positives = 235/414 (56%), Gaps = 34/414 (8%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISE-SSAPDTIELDFPDISF 59
M+ F+ SAPGKVI++GEH+ V+ K A+AA++S LR+YLL++ S + TI ++F DI
Sbjct: 88 MAPAFMVSAPGKVIVYGEHAVVHGKAAMAAAIS-LRSYLLVTTLSKSQRTITMNFRDIGL 146
Query: 60 NHKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLS-------ESFHY 112
+H W+I++ + +K L ELV+ + P +S H
Sbjct: 147 DHTWNIDELPWDVFHHPSKKKFY--YDLVTSLDPELVAAIQPHADAVSPDKPEDVRKIHR 204
Query: 113 HAAFCFLYMFVCL-CPHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMAY-LGGLIGSN 170
+A FLY+F+ L ++L+ST+PIGAGLGSSAS+ V L+ A+ + L G +
Sbjct: 205 RSASAFLYLFLSLGSSQNPGAIYTLRSTIPIGAGLGSSASVCVCLSAALLLQIRTLAGPH 264
Query: 171 DLEKLSENDKHI--VNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNF 228
+ E + I +N+WAF+GE C HG PSG+DN V+ G A++F ++ ++
Sbjct: 265 PDQPPDEAEVQIERINRWAFVGEMCTHGNPSGVDNTVSAGGKAVVFRREDYSKPPTVTP- 323
Query: 229 KFLDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMT 288
L +FP +P++L TR RST VA+V L E +P V IL+A+ + L + +
Sbjct: 324 --LLNFPELPLLLVDTRQSRSTAVEVAKVGKLKDE-YPVVTDSILEAIDQVTLAAQQKIQ 380
Query: 289 KLSKCKGTDDEAVETNNELY---EQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIG 345
++S TN Y E L LIRINHG LVS+GVSHP LE I+ L D IG
Sbjct: 381 EIS-----------TNGISYRTLEDLGTLIRINHGFLVSLGVSHPRLERIRELVDYADIG 429
Query: 346 STKLTGAGGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLL 399
TKLTGAGGGGC++TLLR DI +E + ++KL + + +ET LGG G +L
Sbjct: 430 WTKLTGAGGGGCAITLLRPDIKEEAVRELEEKLSAE-GFVKYETTLGGDGIGVL 482
>ref|XP_001267243.1| mevalonate kinase [Neosartorya fischeri NRRL 181]
gb|EAW25346.1| mevalonate kinase [Neosartorya fischeri NRRL 181]
Length = 538
Score = 246 bits (629), Expect = 2e-63, Method: Composition-based stats.
Identities = 158/411 (38%), Positives = 233/411 (56%), Gaps = 28/411 (6%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISE-SSAPDTIELDFPDISF 59
M+ F+ SAPGKVI++GEH+ V+ K A+AA++S LR+YLL++ S + TI ++F DI
Sbjct: 88 MAPAFMVSAPGKVIVYGEHAVVHGKAAMAAAIS-LRSYLLVTTLSKSQRTITMNFRDIGL 146
Query: 60 NHKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLS-------ESFHY 112
+H W+I++ + +K L ELV+ + P +S H
Sbjct: 147 DHTWNIDELPWDVFHHPSKKKFY--YDLVTSLDPELVAAIQPHADAVSPEKPEDVRKIHR 204
Query: 113 HAAFCFLYMFVCL-CPHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMAY-LGGLIGSN 170
+A FLY+F+ L ++L+ST+PIGAGLGSSAS+ V L+ A+ + L G +
Sbjct: 205 RSASAFLYLFLSLGSSQNPGAIYTLRSTIPIGAGLGSSASVCVCLSAALLLQIRTLAGPH 264
Query: 171 DLEKLSENDKHI--VNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNF 228
+ E + I +N+WAF+GE C HG PSG+DN V+ G A++F ++ ++
Sbjct: 265 PDQPPDEAEVQIERINRWAFVGEMCTHGNPSGVDNTVSAGGKAVVFRREDYSKPPTVTP- 323
Query: 229 KFLDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMT 288
L +FP +P++L TR RST VA+V L E P V IL+A+ + L + +
Sbjct: 324 --LLNFPELPLLLVDTRQSRSTAVEVAKVGKLKDEH-PVVADSILEAIDQVTLAAQQKIQ 380
Query: 289 KLSKCKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTK 348
++S G + +E L LIRINHG LVS+GVSHP LE I+ L D IG TK
Sbjct: 381 EIST-NGISERTLE-------DLGTLIRINHGFLVSLGVSHPRLERIRELVDYADIGWTK 432
Query: 349 LTGAGGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLL 399
LTGAGGGGC++TLLR D +E + ++KL + + +ET LGG G +L
Sbjct: 433 LTGAGGGGCAITLLRPDTKEEAVRELEEKLNAE-GFVKYETTLGGDGIGVL 482
>gb|EEH37797.1| mevalonate kinase [Paracoccidioides brasiliensis Pb01]
Length = 545
Score = 238 bits (606), Expect = 1e-60, Method: Composition-based stats.
Identities = 152/411 (36%), Positives = 226/411 (54%), Gaps = 44/411 (10%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISE-SSAPDTIELDFPDISF 59
M+ F+ SAPGKVI+FGEH+ V+ K A+AA++S LR+YLL++ S + TI L+F DI
Sbjct: 109 MAPAFMVSAPGKVIVFGEHAVVHGKRAMAAAIS-LRSYLLVTTLSKSQRTITLNFRDIEL 167
Query: 60 NHKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLS-------ESFHY 112
+H W I+ Q + +K + L EL+ + P +A +S + H
Sbjct: 168 DHTWDIDSLPWALFCQPSKKKFY--YDSVTSLDPELLEAIQPHIADISIGKPDEVQKIHR 225
Query: 113 HAAFCFLYMFVCLC-PHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMAY-LGGLIGSN 170
+A FLY+F+ L P + ++L+ST+PIGAGLGSSASI+V L+ A+ + L G +
Sbjct: 226 SSATAFLYLFLSLSSPGSHAAIYTLRSTIPIGAGLGSSASIAVCLSAALLLQIRILAGPH 285
Query: 171 DLEKLSENDKHI--VNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNF 228
+ E + I +N+WAF+GE CIHG PSG+DN V+ G A++F + ++ +
Sbjct: 286 HDQPPEEAEVQIERINRWAFVGEMCIHGNPSGVDNTVSAGGKAVIFRRGDYSKPPSVTP- 344
Query: 229 KFLDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMT 288
+ DFP +P++L + P A+ E L ++ +T
Sbjct: 345 --ILDFPELPLLLAGSAKPTP-------------------------AVAESTLAAIDQVT 377
Query: 289 KLSKCKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTK 348
+ + + +NE + EL RINHGLLVS+GVSHP LE I+ L D IG TK
Sbjct: 378 ESANNFIQSGRFDKDSNEDIDHFGELFRINHGLLVSLGVSHPRLERIRELVDHAGIGWTK 437
Query: 349 LTGAGGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLL 399
LTGAGGGGC++ LLR + Q + ++ L DD +E +ET LGG G +L
Sbjct: 438 LTGAGGGGCAIVLLRANTNQAVLHHLEQNL-DDEGFERYETTLGGDGIGVL 487
>ref|XP_001540400.1| conserved hypothetical protein [Ajellomyces capsulatus NAm1]
gb|EDN07730.1| conserved hypothetical protein [Ajellomyces capsulatus NAm1]
Length = 411
Score = 209 bits (532), Expect = 3e-52, Method: Composition-based stats.
Identities = 134/362 (37%), Positives = 199/362 (54%), Gaps = 26/362 (7%)
Query: 49 TIELDFPDISFNHKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLS- 107
TI L+F DI +H W I+ + +K + + L EL+ + P +A +S
Sbjct: 9 TITLNFRDIELDHTWDIDSLPWELFHHPSKKKFYYS--SVTSLDTELLEAIQPHIADISI 66
Query: 108 ------ESFHYHAAFCFLYMFVCLC-PHAKNIKFSLKSTLPIGAGLGSSASISVSLALAM 160
H +A FLY+F+ L P ++L+ST+PIGAGLGSSASI+V L+ A+
Sbjct: 67 GKPDEVRKIHQSSATAFLYLFLSLSSPQTHAAVYTLRSTIPIGAGLGSSASIAVCLSAAL 126
Query: 161 AYLGGLIG---SNDLEKLSENDKHIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKD 217
++ + L + +E +N+WAF+GE CIHG PSG+DN V+ G A++F +
Sbjct: 127 LLQIRILAGPHQDQLPEEAETQIERINKWAFVGEMCIHGNPSGVDNTVSAGGKAVIFRRG 186
Query: 218 SHNGTINTNNFKFLDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMG 277
++ + + DFP +P++L +R PRST VA+V + P V + IL+A+
Sbjct: 187 DYSKPPSVTP---ILDFPELPLLLVNSRQPRSTSVEVAKVANFC-KAHPAVSESILEAID 242
Query: 278 ECALQGLEIMTKLSKCKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKN 337
+ E + L + D ++++E + EL RINHGLLVS+GVSHP LE I+
Sbjct: 243 QVT----ESASNLIQSGRFD----KSSSEAIDHFGELFRINHGLLVSLGVSHPRLERIRE 294
Query: 338 LSDDLRIGSTKLTGAGGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCC 397
L D G TKLTGAGGGGC++TLLR + + +K L DD +E +ET LGG G
Sbjct: 295 LVDHTGSGWTKLTGAGGGGCAITLLRTNTDPAALKRLEKTL-DDEGFERYETILGGHGIG 353
Query: 398 LL 399
+L
Sbjct: 354 VL 355
>gb|EDU45497.1| mevalonate kinase [Pyrenophora tritici-repentis Pt-1C-BFP]
Length = 499
Score = 199 bits (505), Expect = 4e-49, Method: Composition-based stats.
Identities = 145/422 (34%), Positives = 220/422 (52%), Gaps = 62/422 (14%)
Query: 25 KPAVAASVSALRTYLLIS-ESSAPDTIELDFPDISFNHKWSINDFNAITEDQVNSQKLAK 83
+PA A+ +LR+YL +S S + T++L FPDI H W I+ + Q +K
Sbjct: 30 RPAAIAAAISLRSYLHVSFLSKSNRTVKLRFPDIQMEHTWDIDQLPWDSFTQPGKKKYY- 88
Query: 84 AQQATDGLSQELVSLLDPLLAQLS-------ESFHYHAAFCFLYMFVCLCPH-AKNIKFS 135
L +L++ + P + ++S H+ +A+ FLY+F+ L ++
Sbjct: 89 -YDLVTSLDPDLMAAIKPFIDEVSAKAPEHIRKIHHASAYSFLYLFMSLASRKVPPCVYT 147
Query: 136 LKSTLPIGAGLGSSASISVSLALAMAY-LGGLIGSNDLEKLSENDKHI--VNQWAFIGEK 192
L+ST+PIGAGLGSSASISV ++ A+ + L G + + E + +I +N+WAF+GE
Sbjct: 148 LRSTIPIGAGLGSSASISVCISTALLLQIRALSGPHQDQPPQECELNIERINRWAFVGEM 207
Query: 193 CIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLDDFPAIPMILTYTRIPRSTKD 252
CIHG PSG+DN V++ G A+LF++ ++ L FP +P++L TR RST
Sbjct: 208 CIHGNPSGVDNTVSSGGKAVLFQRRDYD---KPPLVVPLHSFPELPLLLVNTRQSRSTAT 264
Query: 253 LVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSKCKGTDDEAVETNNELYEQLL 312
VA+V L P + + IL+A+G +++T D +A T+ + L
Sbjct: 265 EVAKVAHL-RNVHPALTENILNAIGLVTESAHKLLTS------PDFDA--TSPAALKHLG 315
Query: 313 ELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGAGGGGCSLTLLR--------- 363
EL+ INHGLLVS+GVSHP LE I+ + D IG TKLTGAGGGGC++T+L+
Sbjct: 316 ELVTINHGLLVSLGVSHPKLERIREIIDHTGIGWTKLTGAGGGGCAITILKPQPPALTNG 375
Query: 364 -------RDITQEQ-------------------IDSFKKKLQDDFSYETFETDLGGTGCC 397
D + E +DS + KL+ + +E FET L G G
Sbjct: 376 HSHDEPSSDESSEADVDCGSSVISNGTKLKYKILDSLEVKLEQE-GFEKFETTLAGDGVG 434
Query: 398 LL 399
+L
Sbjct: 435 VL 436
>ref|XP_761643.1| hypothetical protein UM05496.1 [Ustilago maydis 521]
gb|EAK86429.1| hypothetical protein UM05496.1 [Ustilago maydis 521]
Length = 953
Score = 197 bits (501), Expect = 2e-48, Method: Composition-based stats.
Identities = 146/398 (36%), Positives = 219/398 (55%), Gaps = 28/398 (7%)
Query: 6 LTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFNHKWSI 65
+ SAPGKVI+FGEH+ V+ AVAASV ALR Y +S I LD PD+ H W+I
Sbjct: 535 VVSAPGKVILFGEHAVVHGITAVAASV-ALRCYANVSPRE-DGKISLDLPDLGVIHTWNI 592
Query: 66 ND--FNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQ-LSESFHYHAA-FCFLYM 121
D ++A+ + + D L + L+ ++ ++ ++ES HAA FL +
Sbjct: 593 ADLPWSAV------PKSIQGGGAVPDSLDKTLIGAIEKVVGDTVNESERSHAASIAFLVL 646
Query: 122 FVCLCPHA--KNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLIGSNDLEKLSEND 179
++C+ A + F L+S LPIGAGLGSSA++S LA A+ L G I + E +E+
Sbjct: 647 YMCIAGQADARAQAFVLRSALPIGAGLGSSAALSSCLAAALTILYGRIPAPGSELSAEHS 706
Query: 180 KHIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLDDFPAIPM 239
HI N+WAF+ EK IHGTPSG+DN VA +G A+ F + + T+ N L F +
Sbjct: 707 THI-NEWAFLSEKVIHGTPSGVDNTVAVHGGAIAFTRAHPSNTLTANKMNKLKGFSSFRF 765
Query: 240 ILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSKCKGTDDE 299
+L + + R K L+A V +K E + AL ++ + ++ T +
Sbjct: 766 LLVDSCVGREGKKLIAHV---AAQKESEPTRV------NAALARIQTIADSAQLVLTGNS 816
Query: 300 AVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIG--STKLTGAGGGGC 357
+ + +E QL ELI+ NH LV + VSH LELIKN ++ +TKLTGAGGGGC
Sbjct: 817 GL-SRSEQVAQLRELIKQNHSELVGLEVSHASLELIKNKTESFAPDQLATKLTGAGGGGC 875
Query: 358 SLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTG 395
++TLL D +E++ +L++ ++ +ET +GG G
Sbjct: 876 AVTLLPDDFEEEKVKELMSELENA-GFKCYETRVGGDG 912
>ref|XP_001628178.1| predicted protein [Nematostella vectensis]
gb|EDO36115.1| predicted protein [Nematostella vectensis]
Length = 415
Score = 193 bits (491), Expect = 2e-47, Method: Composition-based stats.
Identities = 140/417 (33%), Positives = 216/417 (51%), Gaps = 47/417 (11%)
Query: 6 LTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFNHKWSI 65
+ SAPGK+I+ GEH+ VY K A+A S+ LRT +++ + L D+ + W +
Sbjct: 7 VVSAPGKIILHGEHAVVYGKAAIAVSI-GLRTTVVLQRHKNESKVSLLLKDLDYILTWDL 65
Query: 66 NDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFH-----YHAAFCFLY 120
D I V ++++ S E++SL+D L+ S F AA FL+
Sbjct: 66 TDIQKIL---VAVPQVSRTDTVLP--SDEMLSLIDKLID--SSKFVEVEGVKDAARVFLF 118
Query: 121 MFVCLCPHAKN---IKFSLKSTLPIGAGLGSSASISVSLALAM----------AYLGGLI 167
+ I+ +K+ LP+GAGLGSSA+ S+SLA AM Y+
Sbjct: 119 LMTSTLRDRDRLPAIEVEVKTALPLGAGLGSSAAYSISLAAAMLLSMQTIPLPKYVKKTP 178
Query: 168 GSNDLEKLSENDKH---------IVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDS 218
S K +++ ++ +V QWAF EK +HG PSGIDN++ATYG ALLF+
Sbjct: 179 ESETTAKDTDSYQYDDIETESLRLVCQWAFEAEKIMHGQPSGIDNSIATYGGALLFQ--- 235
Query: 219 HNGTINTNNFKFLDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGE 278
NG I L+ P + ++L T+IPRST+ +VA VR E FP V + +A+
Sbjct: 236 -NGEIT-----HLESMPLLSILLIDTQIPRSTRVMVAGVRDRYIE-FPTVYMSLFEAVDG 288
Query: 279 CALQGLEIMTKLSKCKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNL 338
+ ++I +K+ K D E Y++L L+ +N LL GVSHP L+ + ++
Sbjct: 289 ICHECIKIFSKIHNLKNEDVPKSEF-VRYYQRLESLVDVNQQLLSLFGVSHPSLDSLCHM 347
Query: 339 SDDLRIGSTKLTGAGGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTG 395
+ + TKLTGAGGGGC++TL+ ++++ KLQ +F Y+ ++T LG G
Sbjct: 348 TSKYGL-HTKLTGAGGGGCAITLIPPGTDKDKVAELMNKLQKEFKYKVWQTPLGSRG 403
>ref|XP_790690.1| PREDICTED: similar to Mevalonate kinase (MK) [Strongylocentrotus
purpuratus]
ref|XP_001200159.1| PREDICTED: similar to Mevalonate kinase (MK) [Strongylocentrotus
purpuratus]
Length = 413
Score = 189 bits (480), Expect = 4e-46, Method: Composition-based stats.
Identities = 139/409 (33%), Positives = 212/409 (51%), Gaps = 46/409 (11%)
Query: 8 SAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFNHKWSIND 67
SAPGK+I+ GEH+ V+ K A+AA ++ LR+YL + E + + L+ PDI W + +
Sbjct: 19 SAPGKIILHGEHAVVHGKTALAAGLN-LRSYLCLKEKDS-GRLHLNLPDIDLERSWDVLE 76
Query: 68 FNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLA-QLSESFHYHAAFCFLYMFVCLC 126
D +NS + S E++ L L +E+ A FLY+++C+
Sbjct: 77 LQEQFRDLLNSDVMEVKP------SVEIMQRLRLFLGYSDTETTKRLAVMAFLYLYLCIA 130
Query: 127 PHAKNIKFSL-----KSTLPIGAGLGSSASISVSLAL-----AMAYLGGLIGSNDLEKLS 176
+N KF + S LP GAGLGSSA+ SV LA A A + + N L+ S
Sbjct: 131 --GRNGKFPILDTLVSSALPPGAGLGSSAAFSVCLAAGLLTWAKAIIPLSLSDNTLD-WS 187
Query: 177 ENDKHIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLDDFPA 236
D ++N WA+ GE+ IHG PSGIDN+++ +G A+ + + L++ P
Sbjct: 188 REDMELINTWAYEGERVIHGNPSGIDNSISVHGGAIEYRQKV---------ITPLENMPE 238
Query: 237 IPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSKCKGT 296
+ ++L T + RSTK+LVA V+ +K+P+V PILD++ E + + + L +
Sbjct: 239 LSILLVNTCVARSTKELVAGVQ-RRHDKYPKVYGPILDSIEEISQECKRTLQALKTGESL 297
Query: 297 DDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGAGGGG 356
D + ++ L EL+ IN LL IGVSHP + I + +I KLTGAGGGG
Sbjct: 298 DKDGA------FKSLGELVDINQQLLYVIGVSHPAINNIVRSAAAYKI-HAKLTGAGGGG 350
Query: 357 CSLTLLRRDITQEQIDSFKKKLQDDF---SYETFETDLGGTGCCLLSAK 402
C LL DI ++ + K LQ D +YE++ T LG G + +K
Sbjct: 351 CVFALLPPDIPKDSV----KALQADLFRHNYESWITSLGAHGVMMHRSK 395
>ref|NP_592837.1| mevalonate kinase Erg12 (predicted) [Schizosaccharomyces pombe
972h-]
sp|Q09780|KIME_SCHPO Putative mevalonate kinase (MK)
emb|CAA91104.1| mevalonate kinase Erg12 (predicted) [Schizosaccharomyces pombe]
dbj|BAA25169.1| putative mevalonate kinase [Schizosaccharomyces pombe]
Length = 404
Score = 179 bits (455), Expect = 3e-43, Method: Composition-based stats.
Identities = 134/404 (33%), Positives = 207/404 (51%), Gaps = 33/404 (8%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFN 60
MS + S+PGK I+FGEH+ VY A+AA+VS LR+Y + +++ + I + DI
Sbjct: 1 MSKSLIVSSPGKTILFGEHAVVYGATALAAAVS-LRSYCKL-QTTNNNEIVIVMSDIGTE 58
Query: 61 HKWSIND--FNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCF 118
+W++ + +T + V Q + +L+ L LL + A C
Sbjct: 59 RRWNLQSLPWQHVTVENV--------QHPASSPNLDLLQGLGELLKNEENGLIHSAMLCT 110
Query: 119 LYMFVCLCPHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLIGSNDLEKLSEN 178
LY+F L ++ ++ S +P+GAGLGSSA+ISV +A ++ G I L N
Sbjct: 111 LYLFTSLSSPSQGCTLTISSQVPLGAGLGSSATISVVVATSLLLAFGNIEPPSSNSLQNN 170
Query: 179 DK-HIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEK-DSHNGTINTNNFKFLDDFPA 236
++ W+F+GE CIHGTPSGIDNAVAT G + F K +H + +FL
Sbjct: 171 KALALIEAWSFLGECCIHGTPSGIDNAVATNGGLIAFRKATAHQSAMK----EFLKPKDT 226
Query: 237 IPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSKCKGT 296
+ +++T T+ P+STK LV V L E+ P V+ I+DA+ + + +T S
Sbjct: 227 LSVMITDTKQPKSTKKLVQGVFEL-KERLPTVIDSIIDAIDGISKSAVLALTSESD---- 281
Query: 297 DDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGAGGGG 356
N ++L E I +N LL +GVSH ++ + L IG TKLTGAGGGG
Sbjct: 282 -------KNSSAKKLGEFIVLNQKLLECLGVSHYSIDRV--LQATKSIGWTKLTGAGGGG 332
Query: 357 CSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLS 400
C++TLL + +E+ K+ L ++ LGG G +++
Sbjct: 333 CTITLLTPECKEEEFKLCKESLLAH-KNSIYDVQLGGPGVSVVT 375
>ref|XP_001836355.1| hypothetical protein CC1G_06440 [Coprinopsis cinerea okayama7#130]
gb|EAU85539.1| hypothetical protein CC1G_06440 [Coprinopsis cinerea okayama7#130]
Length = 914
Score = 176 bits (445), Expect = 5e-42, Method: Composition-based stats.
Identities = 142/422 (33%), Positives = 223/422 (52%), Gaps = 48/422 (11%)
Query: 3 LPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDI-SFNH 61
L + SAPGKVI+FGEH+ V+ A+AASV LR Y L + + + + F D+ +F H
Sbjct: 444 LEWFVSAPGKVILFGEHAVVHGVTAIAASVD-LRCYGLTTPRT-DNKLSAHFKDLGNFYH 501
Query: 62 KWSIND--FNAITEDQVNSQKLAKAQQATDGLSQELV-SLLDPLLAQL-SESFHYHAA-- 115
+W I+ ++A+T + ++ + L Q L+ +L +LA+L E+ AA
Sbjct: 502 EWDIDSLPWDALT-------PIPPGEEHPEELDQRLIEALSQSVLAELGDENKQARAATL 554
Query: 116 -FCFLYMFVCLCPHAKNIKFSLKSTLPIGAGLGSSAS---------------ISVSLALA 159
F +LYM + H + F+ ++TLP+GAGLGSSAS ISV A
Sbjct: 555 AFLYLYMTLARGQHRPSFNFTARATLPVGAGLGSSASFSACAATALLLLHRRISVPAKPA 614
Query: 160 MAYLGGLIGSNDLEK-LSENDKHIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDS 218
+ + S++ + L + VN+WAF+ EK +HG PSG+DN+VA +G AL + +
Sbjct: 615 PSTETHIHVSHEGRRALPASVAEDVNRWAFVAEKILHGNPSGVDNSVAVFGGALAYTRP- 673
Query: 219 HNGTINTNNFKFLDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGE 278
G + + F ++ +LT +++PR TK LVA V E PE++ IL A+
Sbjct: 674 --GFGKKGGMEQIQGFKSLKFLLTNSQVPRDTKKLVAGVGE-KKENEPELVNGILAAIQS 730
Query: 279 CALQGLEIMTKLSKCKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNL 338
+ + + D E + + L L ELI+ NH LV++GVSHP LE I+
Sbjct: 731 ISDEARRALA--------DPEL--SRDALLSALQELIKENHDHLVTLGVSHPSLEKIREK 780
Query: 339 SDDLRIGSTKLTGAGGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCL 398
+ + TKLTGAGGGGC++TL+ D +E ++ +L + + + T +GG+G +
Sbjct: 781 TSEPYGLKTKLTGAGGGGCAVTLIPDDFKEEVLNGLIDELIRE-GFHPYLTSVGGSGLGI 839
Query: 399 LS 400
LS
Sbjct: 840 LS 841
>ref|XP_645383.1| hypothetical protein DDBDRAFT_0168621 [Dictyostelium discoideum
AX4]
sp|Q86AG7|KIME_DICDI Mevalonate kinase (MK)
gb|AAO51522.1| similar to Rattus norvegicus (Rat). Mevalonate kinase (EC 2.7.1.36)
(MK) [Dictyostelium discoideum]
gb|EAL71443.1| hypothetical protein DDBDRAFT_0168621 [Dictyostelium discoideum
AX4]
Length = 390
Score = 175 bits (443), Expect = 8e-42, Method: Composition-based stats.
Identities = 138/402 (34%), Positives = 224/402 (55%), Gaps = 47/402 (11%)
Query: 8 SAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDIS-FN-HKWSI 65
SAPGK+I+FGEH+ V K A+A+++S LRT + + ++ +T+ LDFPD++ F +WS+
Sbjct: 12 SAPGKIILFGEHAVVLEKTAIASALS-LRTTVTFTPNTN-NTLLLDFPDLAGFGVREWSL 69
Query: 66 NDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLYMFVCL 125
++F + + N + K + ++ QEL ++D + H F FL+ +
Sbjct: 70 DEFKKL-DHFPNDIDILKPIECSELFQQELNKIID------IKGIH---TFLFLFCALTK 119
Query: 126 CPHAKNIKFSLKSTLPIGAGLGSSASISVSLALAM-----AYLGG----LIGSNDLEKLS 176
C A NIK + S LPIGAGLGSSAS VS+ + Y+ G IG ++
Sbjct: 120 CTKAYNIKIT--SDLPIGAGLGSSASFCVSICAGLLKAFDTYICGGCKQCIGGQGQQQQI 177
Query: 177 ENDK-HIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLDD-F 234
N++ +++N W+ GEK +HGTPSGIDNAVAT+G AL F + N +K L++
Sbjct: 178 CNEQLNLINLWSLQGEKIMHGTPSGIDNAVATFGKALTFTR--------KNGYKILENGI 229
Query: 235 PAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSKCK 294
P + +++T TR+ RSTK LV V + ++ +P ++ P+ + + + Q +E + K
Sbjct: 230 PPLRILITNTRVSRSTKTLVEGV-IQRSKLYPTLIDPVSNLIDTISSQCIESFNQYHTDK 288
Query: 295 GTDDEAVETNNELYEQLLELIRINHGLLVSI-GVSHPGLELIKNLSDDLRIGSTKLTGAG 353
D E ++ +L + +N LL GV H ++ I +++ L TKLTGAG
Sbjct: 289 --DYEKLQQTMDL------MFDMNQHLLSGCYGVGHSSIDTIVSITKSLGF-HTKLTGAG 339
Query: 354 GGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTG 395
GGGC +TLL++D T +Q+ + K L + +E++E +G G
Sbjct: 340 GGGCVITLLKQDTTIDQLSNLKLTLSSN-GFESWEATIGDPG 380
>ref|XP_001364115.1| PREDICTED: similar to mevalonate kinase [Monodelphis domestica]
Length = 396
Score = 172 bits (435), Expect = 6e-41, Method: Composition-based stats.
Identities = 145/426 (34%), Positives = 220/426 (51%), Gaps = 64/426 (15%)
Query: 5 FLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFNHKWS 64
L SAPGKVI+ GEH+ V+ K A+A +++ LRT+L + + L P++ + +W
Sbjct: 6 LLVSAPGKVILHGEHAVVHGKVALAEALN-LRTFLRM-RPHKDGKVRLVLPNLETSREWD 63
Query: 65 INDFN-------------AITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFH 111
++ A T +QV K A A T +E +++L
Sbjct: 64 VSKLQLLHASFLDSGEPTAPTTEQVEKLK-AFAGFMTGSSERECLAVL------------ 110
Query: 112 YHAAFCFLYMFVCLCPHA-KNIKFSLKSTLPIGAGLGSSASISVSLALAM-----AYLGG 165
AF +LY+F+C ++ + S LP GAGLGSSA+ SV LA A+ +
Sbjct: 111 ---AFLYLYLFICRKHRPLPSMDIVVWSELPTGAGLGSSAAYSVCLAAALLASCEEIMNR 167
Query: 166 LIGSNDLEKLSENDKHIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINT 225
L + +E++ +++N+WAF+GEK IHG PSG+DN+V+T+G AL F+K
Sbjct: 168 LKEGATSARWNEDELNLINRWAFLGEKVIHGNPSGVDNSVSTWGGALRFQK--------- 218
Query: 226 NNFKFLDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPIL---DAMGECALQ 282
N L P + ++LT T++PRSTK LVA V+ + KFPE+M P+L DA+ + +
Sbjct: 219 GNISSLQRIPVLKILLTNTKVPRSTKALVASVKDRLA-KFPEIMNPLLVSIDAISQECER 277
Query: 283 GLEIMTKLSKCKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDL 342
L +M A E Y L ELI +N L +IGV H L+ + ++
Sbjct: 278 VLGVM------------AATPTPEQYMVLEELIDMNQHHLNAIGVGHSSLDRLCQVTAAH 325
Query: 343 RIGSTKLTGAGGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAK 402
+ S KLTGAGGGGC TLLR + Q +++ K+ L +E +ET +GG G L S
Sbjct: 326 GLHS-KLTGAGGGGCGFTLLRPGLDQSVVEAIKQALT-SCGFECWETTIGGPGVSLHSEA 383
Query: 403 NLNKDL 408
+L ++
Sbjct: 384 SLKANV 389
>ref|XP_001657825.1| mevalonate kinase [Aedes aegypti]
gb|EAT41980.1| mevalonate kinase [Aedes aegypti]
Length = 397
Score = 172 bits (435), Expect = 7e-41, Method: Composition-based stats.
Identities = 137/385 (35%), Positives = 189/385 (49%), Gaps = 55/385 (14%)
Query: 5 FLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFNHKWS 64
F SAPGKVI+ GEHS VY KPA+A + LRTYL + P+ I LDF I F K S
Sbjct: 7 FEISAPGKVILHGEHSVVYGKPAIAGPI-GLRTYLTYKKLDVPEII-LDFASIPFTSKLS 64
Query: 65 INDFNAITE------DQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCF 118
+ FN + D + L+K + + + + VS P AQ S Y
Sbjct: 65 LESFNQFLQQHNCHSDMQPLEFLSKLRTSEEFPFAQYVS---PQPAQDSTKERYSLGVA- 120
Query: 119 LYMF--------VCLCPHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYL------G 164
LY+ V P + ++KS + IGAGLGSSA V ++ A AY+ G
Sbjct: 121 LYLINRIMRSEGVDALPTKSGFQLTIKSVMSIGAGLGSSAGYGVCVS-AGAYVITKLAKG 179
Query: 165 GLIGSNDLE-KLSENDKHI---VNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHN 220
L N L N+ + ++QWAF E +H PSGIDN + TYGN + F K
Sbjct: 180 ELTVDNALNYSFQGNEPEVLKKISQWAFDSELVMHERPSGIDNTICTYGNLIKFRKGE-- 237
Query: 221 GTINTNNFKFLDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECA 280
F+ L I +++ T++ R+T LVA V L K P++M+ ILDAMG
Sbjct: 238 ------PFESLKLRQQINILIVDTKVSRTTSKLVANVAAL-KNKHPKMMESILDAMGHLV 290
Query: 281 LQGLEIMTKLSKCKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSD 340
+E++ E + +E L L+ +N+ LL +IGVSHP LE + L+D
Sbjct: 291 DDAVELL--------------EDERDQFEALRTLVAVNNNLLRAIGVSHPSLEKVFQLAD 336
Query: 341 DLRIGSTKLTGAGGGGCSLTLLRRD 365
+ KLTGAGGGGC+L L +D
Sbjct: 337 SSGFDA-KLTGAGGGGCALVFLPKD 360
>dbj|BAD92959.1| mevalonate kinase variant [Homo sapiens]
Length = 421
Score = 171 bits (434), Expect = 8e-41, Method: Composition-based stats.
Identities = 133/417 (31%), Positives = 225/417 (53%), Gaps = 36/417 (8%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFN 60
+S L SAPGKVI+ GEH+ V+ K A+A S++ LRT+L + S ++L+ P+I
Sbjct: 27 LSEVLLVSAPGKVILHGEHAVVHGKVALAVSLN-LRTFLRLQPHSN-GKVDLNLPNIGIK 84
Query: 61 HKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLY 120
W + ++ + + +E+ L D ++E A FLY
Sbjct: 85 RAWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDD--CAVTERL---AVLAFLY 139
Query: 121 MFVCLCPHAK---NIKFSLKSTLPIGAGLGSSASISVSLALAMAYL-----GGLIGSNDL 172
+++ +C + ++ + S LP GAGLGSSA+ SV LA A+ + L + +
Sbjct: 140 LYLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCV 199
Query: 173 EKLSENDKHIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLD 232
+ ++ D ++N+WAF GE+ IHG PSG+DNAV+T+G AL + H G I++ L
Sbjct: 200 NRWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRY----HQGKISS-----LK 250
Query: 233 DFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSK 292
PA+ ++LT T++PR+T+ LVA VR + KFPE++ P+L ++ +L+ ++ ++ +
Sbjct: 251 RSPALQILLTNTKVPRNTRALVAGVRNRLL-KFPEIVAPLLTSIDAISLECERVLGEMGE 309
Query: 293 CKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGA 352
E Y L ELI +N L ++GV H L+ + ++ R +KLTGA
Sbjct: 310 APAP---------EQYLVLEELIDMNQHHLNALGVGHASLDQLCQVT-RARGLHSKLTGA 359
Query: 353 GGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLNKDLK 409
GGGGC +TLL+ + Q ++++ K+ L ++ ET +G G + SA +L+ ++
Sbjct: 360 GGGGCGITLLKPGLEQPEVEATKQALT-SCGFDCLETSIGAPGVSIHSATSLDSRVQ 415
>emb|CAA53059.1| unnamed protein product [Hepatitis B virus]
Length = 557
Score = 171 bits (433), Expect = 1e-40, Method: Composition-based stats.
Identities = 133/417 (31%), Positives = 224/417 (53%), Gaps = 36/417 (8%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFN 60
+S L SAPGKVI+ GEH+ V+ K A+A S++ LRT+L + S ++L P+I
Sbjct: 163 LSEVLLVSAPGKVILHGEHAVVHGKVALAVSLN-LRTFLRLQPHSN-GKVDLSLPNIGIK 220
Query: 61 HKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLY 120
W + ++ + + +E+ L D ++E A FLY
Sbjct: 221 RAWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDD--CAVTERL---AVLAFLY 275
Query: 121 MFVCLCPHAK---NIKFSLKSTLPIGAGLGSSASISVSLALAMAYL-----GGLIGSNDL 172
+++ +C + ++ + S LP GAGLGSSA+ SV LA A+ + L + +
Sbjct: 276 LYLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCV 335
Query: 173 EKLSENDKHIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLD 232
+ ++ D ++N+WAF GE+ IHG PSG+DNAV+T+G AL + H G I++ L
Sbjct: 336 NRWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRY----HQGKISS-----LK 386
Query: 233 DFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSK 292
PA+ ++LT T++PR+T+ LVA VR + KFPE++ P+L ++ +L+ ++ ++ +
Sbjct: 387 RSPALQILLTNTKVPRNTRALVAGVRNRLL-KFPEIVAPLLTSIDAISLECERVLGEMGE 445
Query: 293 CKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGA 352
E Y L ELI +N L ++GV H L+ + ++ R +KLTGA
Sbjct: 446 APAP---------EQYLVLEELIDMNQHHLNALGVGHASLDQLCQVT-RARGLHSKLTGA 495
Query: 353 GGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLNKDLK 409
GGGGC +TLL+ + Q ++++ K+ L ++ ET +G G + SA +L+ ++
Sbjct: 496 GGGGCGITLLKPGLEQPEVEATKQALT-SCGFDCLETSIGAPGVSIHSATSLDSRVQ 551
>ref|NP_000422.1| mevalonate kinase [Homo sapiens]
ref|NP_001107657.1| mevalonate kinase [Homo sapiens]
sp|Q03426|KIME_HUMAN Mevalonate kinase (MK)
gb|AAB59362.1| mevalonate kinase
emb|CAA53060.1| unnamed protein product [Homo sapiens]
gb|AAF82407.1| mevalonate kinase [Homo sapiens]
gb|AAH16140.1| MVK protein [Homo sapiens]
gb|EAW97872.1| mevalonate kinase (mevalonic aciduria), isoform CRA_c [Homo
sapiens]
gb|EAW97873.1| mevalonate kinase (mevalonic aciduria), isoform CRA_c [Homo
sapiens]
gb|ABM82015.1| mevalonate kinase (mevalonic aciduria) [synthetic construct]
gb|ABM85197.1| mevalonate kinase (mevalonic aciduria) [synthetic construct]
Length = 396
Score = 171 bits (432), Expect = 1e-40, Method: Composition-based stats.
Identities = 133/417 (31%), Positives = 224/417 (53%), Gaps = 36/417 (8%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFN 60
+S L SAPGKVI+ GEH+ V+ K A+A S++ LRT+L + S ++L P+I
Sbjct: 2 LSEVLLVSAPGKVILHGEHAVVHGKVALAVSLN-LRTFLRLQPHSN-GKVDLSLPNIGIK 59
Query: 61 HKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLY 120
W + ++ + + +E+ L D ++E A FLY
Sbjct: 60 RAWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDD--CAVTERL---AVLAFLY 114
Query: 121 MFVCLCPHAK---NIKFSLKSTLPIGAGLGSSASISVSLALAMAYL-----GGLIGSNDL 172
+++ +C + ++ + S LP GAGLGSSA+ SV LA A+ + L + +
Sbjct: 115 LYLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCV 174
Query: 173 EKLSENDKHIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLD 232
+ ++ D ++N+WAF GE+ IHG PSG+DNAV+T+G AL + H G I++ L
Sbjct: 175 NRWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRY----HQGKISS-----LK 225
Query: 233 DFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSK 292
PA+ ++LT T++PR+T+ LVA VR + KFPE++ P+L ++ +L+ ++ ++ +
Sbjct: 226 RSPALQILLTNTKVPRNTRALVAGVRNRLL-KFPEIVAPLLTSIDAISLECERVLGEMGE 284
Query: 293 CKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGA 352
E Y L ELI +N L ++GV H L+ + ++ R +KLTGA
Sbjct: 285 APAP---------EQYLVLEELIDMNQHHLNALGVGHASLDQLCQVT-RARGLHSKLTGA 334
Query: 353 GGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLNKDLK 409
GGGGC +TLL+ + Q ++++ K+ L ++ ET +G G + SA +L+ ++
Sbjct: 335 GGGGCGITLLKPGLEQPEVEATKQALT-SCGFDCLETSIGAPGVSIHSATSLDSRVQ 390
>gb|AAQ02416.1| mevalonate kinase [synthetic construct]
Length = 397
Score = 171 bits (432), Expect = 1e-40, Method: Composition-based stats.
Identities = 133/417 (31%), Positives = 224/417 (53%), Gaps = 36/417 (8%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFN 60
+S L SAPGKVI+ GEH+ V+ K A+A S++ LRT+L + S ++L P+I
Sbjct: 2 LSEVLLVSAPGKVILHGEHAVVHGKVALAVSLN-LRTFLRLQPHSN-GKVDLSLPNIGIK 59
Query: 61 HKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLY 120
W + ++ + + +E+ L D ++E A FLY
Sbjct: 60 RAWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDD--CAVTERL---AVLAFLY 114
Query: 121 MFVCLCPHAK---NIKFSLKSTLPIGAGLGSSASISVSLALAMAYL-----GGLIGSNDL 172
+++ +C + ++ + S LP GAGLGSSA+ SV LA A+ + L + +
Sbjct: 115 LYLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCV 174
Query: 173 EKLSENDKHIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLD 232
+ ++ D ++N+WAF GE+ IHG PSG+DNAV+T+G AL + H G I++ L
Sbjct: 175 NRWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRY----HQGKISS-----LK 225
Query: 233 DFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSK 292
PA+ ++LT T++PR+T+ LVA VR + KFPE++ P+L ++ +L+ ++ ++ +
Sbjct: 226 RSPALQILLTNTKVPRNTRALVAGVRNRLL-KFPEIVAPLLTSIDAISLECERVLGEMGE 284
Query: 293 CKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGA 352
E Y L ELI +N L ++GV H L+ + ++ R +KLTGA
Sbjct: 285 APAP---------EQYLVLEELIDMNQHHLNALGVGHASLDQLCQVT-RARGLHSKLTGA 334
Query: 353 GGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLNKDLK 409
GGGGC +TLL+ + Q ++++ K+ L ++ ET +G G + SA +L+ ++
Sbjct: 335 GGGGCGITLLKPGLEQPEVEATKQALT-SCGFDCLETSIGAPGVSIHSATSLDSRVQ 390
>ref|XP_543435.2| PREDICTED: similar to Mevalonate kinase (MK) [Canis familiaris]
Length = 409
Score = 171 bits (432), Expect = 1e-40, Method: Composition-based stats.
Identities = 146/435 (33%), Positives = 229/435 (52%), Gaps = 68/435 (15%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFN 60
+S L SAPGKVI+ GEH+ V+ K A+A +++ LRT+L + S + L+ P+I
Sbjct: 11 LSEVLLVSAPGKVILHGEHAVVHGKIALAVALN-LRTFLRLQPHSN-GKMCLNLPNIGVK 68
Query: 61 HKWSI-----------------NDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLL 103
W + D A T +QV K A DG E +++L
Sbjct: 69 RAWDVARLQLQDTSFLEPGNATGDAAAPTSEQVEKLKEV-AGIPKDGADPECLAVL---- 123
Query: 104 AQLSESFHYHAAFCFLYMFVCLCPHAK---NIKFSLKSTLPIGAGLGSSASISVSLALAM 160
FLY+++ +C + ++ ++ S LP GAGLGSSA+ SV LA A+
Sbjct: 124 -------------AFLYLYLSICRKQRTLPSLDITVWSELPTGAGLGSSAAYSVCLAAAL 170
Query: 161 AYLGGLIGS--NDLEKLSE---NDKHIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFE 215
I + N+ E S D ++N+WAF GE+ IHG PSG+DN ++T+G AL ++
Sbjct: 171 LTACEAIPNPQNNGESASRWTMEDLELINKWAFQGERMIHGNPSGVDNTISTWGGALRYQ 230
Query: 216 KDSHNGTINTNNFKFLDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDA 275
+ G I++ + PA+ ++LT T++PRSTK LVA VR + KFPE++ P+L +
Sbjct: 231 Q----GKISS-----IKRLPALKILLTNTKVPRSTKALVASVRSRLL-KFPEIVAPLLTS 280
Query: 276 MGECALQGLEIMTKLSKCKGTDDE-AVETNNELYEQLLELIRINHGLLVSIGVSHPGLEL 334
+ +L+ C+ T +E A E Y L ELI IN L ++GV H L+
Sbjct: 281 INAISLE----------CERTLEEMASAPAPEHYLVLEELIDINQHHLNALGVGHASLDQ 330
Query: 335 IKNLSDDLRIGSTKLTGAGGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGT 394
+ ++ + S KLTGAGGGGC +TLLR D+ Q ++++ K+ L ++ +ET +G
Sbjct: 331 LCQVTMAHGLHS-KLTGAGGGGCGITLLRPDLEQPKVEAMKQALT-SCGFDCWETRIGAP 388
Query: 395 GCCLLSAKNLNKDLK 409
G + SA +L+ ++
Sbjct: 389 GISIHSAASLDTQVQ 403
>ref|XP_001846214.1| mevalonate kinase [Culex pipiens quinquefasciatus]
gb|EDS42994.1| mevalonate kinase [Culex pipiens quinquefasciatus]
Length = 389
Score = 170 bits (431), Expect = 2e-40, Method: Composition-based stats.
Identities = 137/404 (33%), Positives = 193/404 (47%), Gaps = 40/404 (9%)
Query: 5 FLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFNHKWS 64
F SAPGKVI+ GEHS VY KPA+A + LRTYL +P+ I LDF I FN S
Sbjct: 6 FEVSAPGKVILHGEHSVVYGKPAIAGPI-GLRTYLTYKRLQSPEVI-LDFASIPFNSSLS 63
Query: 65 INDFNAITED---QVNSQKLA--KAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFL 119
+ FNA N Q L + ++ DG P + E F + A L
Sbjct: 64 LESFNAFLAQFDCHSNLQPLEFLEKMRSADGFPFASFVTRQPAQDSIKEKFSFGTALYLL 123
Query: 120 YMFV---CLCPHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLIGSNDLE-KL 175
+ + + +LKS + IGAGLGSSA V ++ A A+L I +LE K
Sbjct: 124 NRILRSEGVESLESGFQLTLKSVMSIGAGLGSSAGYGVCVS-AGAFLLSKIIKGELEAKF 182
Query: 176 SENDK----HIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFL 231
+ D +++WAF E +H PSGIDN + TYGN + F++ F+ L
Sbjct: 183 ALQDSPEVLEKISKWAFDSEIVMHERPSGIDNTICTYGNLIKFKRGE--------PFESL 234
Query: 232 DDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLS 291
+ +++ T + R+T LVA V L + P +M ILDAMG + I+
Sbjct: 235 KLRQQVNILIVDTGVSRTTAKLVAGVADL-KSRHPGMMDAILDAMGHLVDDVVSIL---- 289
Query: 292 KCKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTG 351
E + + +E L L+ IN LL +IGVSHP LE I L+++ S KLTG
Sbjct: 290 ----------EDDGDRFEALRTLVSINGNLLRAIGVSHPSLERIFRLAEESGF-SAKLTG 338
Query: 352 AGGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTG 395
AGGGGC+L L +D + + + + +T +GG G
Sbjct: 339 AGGGGCALVFLPQDYESSKEYAELTQNLTKAGFHWIQTTIGGQG 382
>ref|XP_001105759.1| PREDICTED: mevalonate kinase isoform 2 [Macaca mulatta]
ref|XP_001105815.1| PREDICTED: mevalonate kinase isoform 3 [Macaca mulatta]
Length = 396
Score = 167 bits (424), Expect = 1e-39, Method: Composition-based stats.
Identities = 134/418 (32%), Positives = 228/418 (54%), Gaps = 38/418 (9%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFN 60
+S L SAPGKVI+ GEH+ V+ K A+A +++ LRT+L + S ++L P+I
Sbjct: 2 LSEVLLVSAPGKVILHGEHAVVHGKVALAVALN-LRTFLRLQPHSN-GKVDLSLPNIGIK 59
Query: 61 HKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLD-PLLAQLSESFHYHAAFCFL 119
W + + + A T L ++L + P ++ES A FL
Sbjct: 60 WAWDVARLQLLDTSFLEQ---GDATTPTPELVEKLKEVAGLPDDCAVTESL---AVLAFL 113
Query: 120 YMFVCLCPHAK---NIKFSLKSTLPIGAGLGSSASISVSLALAMAYL-----GGLIGSND 171
Y+++ +C + ++ + S LP GAGLGSSA+ SV LA A+ + L +
Sbjct: 114 YLYLSICRKQRALPSLDIVVWSELPHGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDR 173
Query: 172 LEKLSENDKHIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFL 231
+ + ++ D ++N+WAF GE+ IHG PSG+DNAV+T+G AL +++ G I++ L
Sbjct: 174 VNRWTKEDLELINKWAFQGERVIHGNPSGVDNAVSTWGGALRYQQ----GKISS-----L 224
Query: 232 DDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLS 291
PA+ ++LT T++PR+T+ LVA VR + KFPE++ P+L ++ +L+ ++ ++
Sbjct: 225 KRPPALQILLTNTKVPRNTRTLVAGVRNRLL-KFPEIVAPLLTSIDAISLECERVLGEMG 283
Query: 292 KCKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTG 351
+ E Y L ELI +N L ++GV H L+ + ++ + S KLTG
Sbjct: 284 EAPAP---------EQYLVLEELIDMNQHHLNALGVGHASLDQLCQVTRAHGLHS-KLTG 333
Query: 352 AGGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLNKDLK 409
AGGGGC +TLL+ + Q ++++ K+ L ++ +ET +G G + SA +L+ ++
Sbjct: 334 AGGGGCGITLLKPGLEQPEVEATKQALT-SCGFDCWETSIGAPGVSIHSATSLDSRVQ 390
>ref|XP_001730996.1| hypothetical protein MGL_1995 [Malassezia globosa CBS 7966]
gb|EDP43782.1| hypothetical protein MGL_1995 [Malassezia globosa CBS 7966]
Length = 838
Score = 167 bits (424), Expect = 1e-39, Method: Composition-based stats.
Identities = 125/387 (32%), Positives = 194/387 (50%), Gaps = 31/387 (8%)
Query: 8 SAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFNHKWSIND 67
SAPGKVI+FGEH+ V+ A+ +ALR Y ++ S + L PDI+ W
Sbjct: 442 SAPGKVILFGEHAVVHGV-TAVAAATALRCYGRVTPSKQ-GMVSLSMPDIALEQHW---- 495
Query: 68 FNAITEDQVN-SQKLAKAQQATDGLSQELVSLLDPLL--AQLSESFHYHAAFCFLYMFVC 124
DQ L + D L +L+ L L+ A + Y A+ FLY+++
Sbjct: 496 ------DQAALPWSLYDTSRKLDTLDPQLLEALSMLVSPAYPRDDRRYAASLAFLYLYMH 549
Query: 125 LCPH-AKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLIGSNDL-EKLSENDKHI 182
L + A F L+S+LPI AGLGSSA++S LA + Y + DL E + +
Sbjct: 550 LAQNDALGQAFELRSSLPISAGLGSSAAVSTCLASLLLYTHMHLPLPDLHEPMPKLHTKY 609
Query: 183 VNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLDDFPAIPMILT 242
+N WA++ EK IHG PSG+DN VAT G A+ F + + N + + A+ +++T
Sbjct: 610 INTWAYVAEKVIHGEPSGVDNTVATLGGAVAFTRALPTNHLTENELVPM-NLDAVRVLIT 668
Query: 243 YTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSKCKGTDDEAVE 302
T + R+TKDLVA+V E +P+ +Q L ++ + ++
Sbjct: 669 DTHVIRNTKDLVAKVSAQKNE------EPVRVEAAFAMIQHLS-----TQAQALLRDSTL 717
Query: 303 TNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGAGGGGCSLTLL 362
+ L E+L L+ +NH LV +GV H LE ++ L + R+ KLTGAGGGGC++TLL
Sbjct: 718 SRRHLVERLSVLMDLNHLQLVQLGVGHSALENVRRLCAERRL-CAKLTGAGGGGCAITLL 776
Query: 363 RRDITQEQIDSFKKKLQDDFSYETFET 389
+ + + ++ + T+ET
Sbjct: 777 DDQVDESTVQQLTHAMRAQ-GFTTYET 802
>gb|AAX46713.1| mevalonate kinase [Bos taurus]
Length = 440
Score = 167 bits (424), Expect = 1e-39, Method: Composition-based stats.
Identities = 134/411 (32%), Positives = 220/411 (53%), Gaps = 52/411 (12%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFN 60
+S L SAPGKVI+ GEH+ V+ K A+A +++ LRT+L + S + L+ P+I
Sbjct: 2 LSEALLVSAPGKVILHGEHAVVHGKVALAMALN-LRTFLRLQPHSN-GRVGLNLPNIGVR 59
Query: 61 HKWSI-------NDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYH 113
W + F + + K + + G ++ V DP +
Sbjct: 60 RAWDVASLQLLDTSFLGHGDSAALTAKHVEKLKEVAGFPKDCV---DP---------EHL 107
Query: 114 AAFCFLYMFVCLCPHAK---NIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLIGSN 170
A FLY+++ +C + ++ ++ S LP GAGLGSSA+ SV LA A+ I N
Sbjct: 108 AVLAFLYLYLSICQSQRALPSLDITVWSELPTGAGLGSSAAYSVCLAAALLTACEEI-PN 166
Query: 171 DLE------KLSENDKHIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTIN 224
L+ + +E + ++N+WAF GE+ IHG PSG+DNAV+T+G AL +++ G I+
Sbjct: 167 PLKDGEAAGRWTEENLELINKWAFQGERVIHGNPSGVDNAVSTWGGALRYQQ----GKIS 222
Query: 225 TNNFKFLDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGL 284
+ L P + ++L T++PRSTK LVA VR + KFPE++ P+L ++ +L+
Sbjct: 223 S-----LKRPPVLKILLINTKVPRSTKVLVANVRSRLL-KFPEIVAPLLTSIDAISLECE 276
Query: 285 EIMTKLSKCKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRI 344
++ ++ A E Y L ELI +N L ++GV H L+ + ++ +
Sbjct: 277 RVLGEM---------AAAPTPEHYLTLEELIDMNQHHLNALGVGHASLDQLCQVTTAHGL 327
Query: 345 GSTKLTGAGGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTG 395
S KLTGAGGGGC +TLLR D+ + ++++ K+ L + ++ +ET +G G
Sbjct: 328 HS-KLTGAGGGGCGITLLRPDVERPEVEATKRALS-GYGFDCWETSVGAPG 376
Searching..................................................done
Results from round 2
Score E
Sequences producing significant alignments: (bits) Value
Sequences used in model and found again:
gb|EDN64144.1| mevalonate kinase [Saccharomyces cerevisiae ... 648 0.0
ref|NP_013935.1| Mevalonate kinase, acts in the biosynthesi... 648 0.0
ref|XP_001644409.1| hypothetical protein Kpol_1064p33 [Vand... 455 e-126
ref|NP_985191.1| AER335Wp [Ashbya gossypii ATCC 10895] >gi|... 440 e-122
ref|XP_001229023.1| hypothetical protein CHGG_02507 [Chaeto... 432 e-119
ref|XP_446138.1| unnamed protein product [Candida glabrata]... 431 e-119
ref|XP_001593159.1| hypothetical protein SS1G_06081 [Sclero... 429 e-118
ref|XP_001911734.1| unnamed protein product [Podospora anse... 428 e-118
ref|XP_452532.1| unnamed protein product [Kluyveromyces lac... 424 e-117
ref|XP_386088.1| hypothetical protein FG05912.1 [Gibberella... 423 e-116
ref|XP_001271672.1| mevalonate kinase [Aspergillus clavatus... 421 e-116
ref|XP_661473.1| hypothetical protein AN3869.2 [Aspergillus... 421 e-116
ref|XP_961360.1| hypothetical protein NCU03633 [Neurospora ... 421 e-116
ref|XP_001559870.1| hypothetical protein BC1G_01429 [Botryo... 420 e-116
ref|XP_001382664.2| mevalonate kinase [Pichia stipitis CBS ... 419 e-115
ref|XP_001214601.1| conserved hypothetical protein [Aspergi... 419 e-115
ref|XP_001267243.1| mevalonate kinase [Neosartorya fischeri... 418 e-115
gb|EDP50156.1| mevalonate kinase [Aspergillus fumigatus A1163] 418 e-115
ref|XP_752047.1| mevalonate kinase [Aspergillus fumigatus A... 418 e-115
ref|XP_460851.1| hypothetical protein DEHA0F12188g [Debaryo... 416 e-114
ref|XP_723495.1| mevalonate kinase [Candida albicans SC5314... 416 e-114
ref|XP_001821298.1| hypothetical protein [Aspergillus oryza... 415 e-114
gb|EEH48028.1| mevalonate kinase [Paracoccidioides brasilie... 415 e-114
ref|XP_001401587.1| hypothetical protein An04g02190 [Asperg... 413 e-113
ref|XP_001241830.1| hypothetical protein CIMG_05726 [Coccid... 412 e-113
ref|XP_370449.1| hypothetical protein MGG_06946 [Magnaporth... 408 e-112
ref|XP_001527900.1| hypothetical protein LELG_00420 [Lodder... 406 e-111
gb|EEH37797.1| mevalonate kinase [Paracoccidioides brasilie... 385 e-105
ref|XP_001483309.1| hypothetical protein PGUG_04038 [Pichia... 372 e-101
emb|CAA53059.1| unnamed protein product [Hepatitis B virus] 371 e-101
ref|XP_001105759.1| PREDICTED: mevalonate kinase isoform 2 ... 367 1e-99
dbj|BAD92959.1| mevalonate kinase variant [Homo sapiens] 361 6e-98
ref|NP_000422.1| mevalonate kinase [Homo sapiens] >gi|16700... 360 2e-97
gb|AAQ02416.1| mevalonate kinase [synthetic construct] 360 2e-97
dbj|BAA24409.1| mevalonate kinase [Saccharomyces cerevisiae] 358 6e-97
gb|AAX08684.1| mevalonate kinase [Bos taurus] 357 1e-96
ref|XP_543435.2| PREDICTED: similar to Mevalonate kinase (M... 357 1e-96
ref|NP_001015528.1| mevalonate kinase [Bos taurus] >gi|7506... 356 1e-96
ref|XP_790690.1| PREDICTED: similar to Mevalonate kinase (M... 352 3e-95
gb|AAX46713.1| mevalonate kinase [Bos taurus] 352 4e-95
ref|XP_001364115.1| PREDICTED: similar to mevalonate kinase... 351 9e-95
ref|XP_001496887.1| PREDICTED: similar to mevalonate kinase... 346 1e-93
ref|NP_112325.1| mevalonate kinase [Rattus norvegicus] >gi|... 345 4e-93
ref|XP_500956.1| hypothetical protein [Yarrowia lipolytica]... 345 5e-93
ref|NP_076045.1| mevalonate kinase [Mus musculus] >gi|89281... 341 8e-92
dbj|BAE28997.1| unnamed protein product [Mus musculus] 341 9e-92
ref|XP_001628178.1| predicted protein [Nematostella vectens... 338 7e-91
emb|CAM15186.1| novel protein similar to vertebrate mevalon... 337 1e-90
ref|NP_001007350.1| hypothetical protein LOC492477 [Danio r... 336 2e-90
ref|XP_001540400.1| conserved hypothetical protein [Ajellom... 333 2e-89
gb|EDU45497.1| mevalonate kinase [Pyrenophora tritici-repen... 330 2e-88
emb|CAG08527.1| unnamed protein product [Tetraodon nigrovir... 324 8e-87
ref|NP_592837.1| mevalonate kinase Erg12 (predicted) [Schiz... 324 1e-86
ref|XP_567851.1| cystathionine beta-lyase [Cryptococcus neo... 323 2e-86
ref|XP_567850.1| cystathionine beta-lyase [Cryptococcus neo... 323 3e-86
ref|XP_001836355.1| hypothetical protein CC1G_06440 [Coprin... 320 1e-85
ref|XP_001846214.1| mevalonate kinase [Culex pipiens quinqu... 310 1e-82
ref|XP_001105689.1| PREDICTED: mevalonate kinase isoform 1 ... 310 2e-82
ref|XP_001779131.1| predicted protein [Physcomitrella paten... 309 2e-82
ref|NP_001093299.1| mevalonate kinase [Bombyx mori] >gi|146... 309 3e-82
ref|XP_761643.1| hypothetical protein UM05496.1 [Ustilago m... 308 6e-82
emb|CAO17636.1| unnamed protein product [Vitis vinifera] 307 1e-81
gb|AAD45421.1|L77688_1 mevalonate kinase [Arabidopsis thali... 305 4e-81
ref|XP_624545.2| PREDICTED: similar to Mevalonate kinase (M... 305 5e-81
ref|XP_645383.1| hypothetical protein DDBDRAFT_0168621 [Dic... 304 6e-81
ref|XP_001608063.1| PREDICTED: similar to mevalonate kinase... 303 2e-80
ref|NP_198097.1| MK/MVK; mevalonate kinase [Arabidopsis tha... 302 3e-80
ref|XP_001730996.1| hypothetical protein MGL_1995 [Malassez... 301 7e-80
ref|XP_001657825.1| mevalonate kinase [Aedes aegypti] >gi|1... 299 2e-79
gb|AAL18925.1|AF429384_1 mevalonate kinase [Hevea brasilien... 298 7e-79
ref|NP_001064360.1| Os10g0329300 [Oryza sativa (japonica cu... 298 7e-79
gb|ABK95983.1| unknown [Populus trichocarpa] 296 3e-78
ref|NP_001027412.1| CG33671 CG33671-PA [Drosophila melanoga... 288 6e-76
ref|XP_319701.4| AGAP008947-PA [Anopheles gambiae str. PEST... 283 2e-74
ref|XP_918559.1| PREDICTED: similar to mevalonate kinase [M... 276 3e-72
gb|AAL31086.1|AC091749_15 putative mevalonate kinase [Oryza... 274 1e-71
ref|XP_972334.1| PREDICTED: similar to mevalonate kinase [T... 273 2e-71
gb|ABD32397.1| Mevalonate and galactokinase [Medicago trunc... 272 4e-71
ref|NP_143478.1| mevalonate kinase [Pyrococcus horikoshii O... 269 2e-70
ref|NP_126232.1| mevalonate kinase [Pyrococcus abyssi GE5] ... 269 4e-70
ref|NP_001022868.1| Y42G9A.4c [Caenorhabditis elegans] >gi|... 269 4e-70
ref|YP_183887.1| mevalonate kinase [Thermococcus kodakarens... 268 5e-70
ref|NP_001022869.1| Y42G9A.4d [Caenorhabditis elegans] >gi|... 267 1e-69
ref|NP_001022867.1| Y42G9A.4b [Caenorhabditis elegans] >gi|... 265 4e-69
ref|NP_579366.1| mevalonate kinase [Pyrococcus furiosus DSM... 262 3e-68
ref|YP_658630.1| mevalonate kinase [Haloquadratum walsbyi D... 258 5e-67
ref|ZP_03999700.1| mevalonate kinase [Halogeometricum borin... 256 2e-66
gb|ABR68258.1| mevalonate kinase [Monodelphis domestica] 256 4e-66
ref|YP_920295.1| mevalonate kinase [Thermofilum pendens Hrk... 254 1e-65
ref|YP_001547075.1| mevalonate kinase [Herpetosiphon aurant... 248 5e-64
ref|ZP_02015315.1| mevalonate kinase [Halorubrum lacusprofu... 247 1e-63
ref|YP_001276466.1| mevalonate kinase [Roseiflexus sp. RS-1... 246 2e-63
ref|YP_447890.1| putative mevalonate kinase [Methanosphaera... 244 1e-62
gb|AAX46707.1| mevalonate kinase [Bos taurus] 243 2e-62
ref|YP_134862.1| mevalonate kinase [Haloarcula marismortui ... 239 3e-61
gb|EAZ05750.1| hypothetical protein OsI_026982 [Oryza sativ... 239 4e-61
ref|YP_327075.1| mevalonate kinase [Natronomonas pharaonis ... 236 3e-60
ref|YP_001634502.1| mevalonate kinase [Chloroflexus auranti... 234 1e-59
ref|YP_001431846.1| mevalonate kinase [Roseiflexus castenho... 233 2e-59
ref|ZP_03940390.1| possible mevalonate kinase [Lactobacillu... 233 2e-59
ref|ZP_03943398.1| possible mevalonate kinase [Lactobacillu... 231 8e-59
ref|XP_001900710.1| mevalonate kinase family protein [Brugi... 231 1e-58
ref|NP_633786.1| mevalonate kinase [Methanosarcina mazei Go... 231 1e-58
ref|ZP_01695505.1| mevalonate kinase [Bacillus coagulans 36... 230 2e-58
ref|YP_001040239.1| mevalonate kinase [Staphylothermus mari... 230 2e-58
ref|XP_001794454.1| hypothetical protein SNOG_03909 [Phaeos... 230 2e-58
ref|XP_001567071.1| mevalonate kinase, putative [Leishmania... 230 2e-58
ref|YP_566996.1| mevalonate kinase [Methanococcoides burton... 229 3e-58
ref|ZP_03954541.1| possible mevalonate kinase [Lactobacillu... 229 3e-58
ref|YP_684687.1| mevalonate kinase [uncultured methanogenic... 229 3e-58
ref|YP_842907.1| mevalonate kinase [Methanosaeta thermophil... 229 4e-58
ref|YP_001197657.1| Mevalonate kinase [Streptococcus suis 0... 228 6e-58
emb|CAN77024.1| hypothetical protein [Vitis vinifera] 227 1e-57
gb|EAY78050.1| hypothetical protein OsI_032009 [Oryza sativ... 225 5e-57
ref|XP_001467381.1| mevalonate kinase [Leishmania infantum ... 225 5e-57
ref|ZP_03873469.1| mevalonate kinase [Halomicrobium mukohat... 225 6e-57
gb|EAZ15677.1| hypothetical protein OsJ_029886 [Oryza sativ... 225 6e-57
ref|XP_001685041.1| mevalonate kinase, putative [Leishmania... 222 5e-56
ref|ZP_00875673.1| Mevalonate kinase [Streptococcus suis 89... 222 5e-56
pdb|2HFU|A Chain A, Crystal Structure Of L. Major Mevalonat... 222 5e-56
gb|AAG02440.1|AF290093_1 mevalonate kinase [Enterococcus fa... 220 1e-55
ref|ZP_02185318.1| mevalonate kinase [Carnobacterium sp. AT... 220 1e-55
ref|ZP_03947872.1| mevalonate kinase [Enterococcus faecalis... 219 4e-55
ref|NP_280049.1| Mvk [Halobacterium sp. NRC-1] >gi|16923595... 218 7e-55
ref|NP_814642.1| mevalonate kinase [Enterococcus faecalis V... 218 9e-55
ref|YP_808480.1| Mevalonate kinase [Lactococcus lactis subs... 217 1e-54
ref|NP_266560.1| mevalonate kinase [Lactococcus lactis subs... 217 2e-54
ref|ZP_03871887.1| mevalonate kinase [Halorhabdus utahensis... 215 4e-54
pdb|2HFS|A Chain A, Crystal Structure Of L. Major Mevalonat... 215 5e-54
ref|ZP_01514039.1| mevalonate kinase [Chloroflexus aggregan... 214 9e-54
ref|YP_848214.1| mevalonate kinase [Listeria welshimeri ser... 214 1e-53
ref|YP_001031775.1| Mvk protein [Lactococcus lactis subsp. ... 214 2e-53
ref|XP_844557.1| mevalonate kinase, putative [Trypanosoma b... 213 2e-53
pdb|1VIS|A Chain A, Crystal Structure Of Mevalonate Kinase 213 2e-53
ref|YP_001620791.1| mevalonate kinase [Acholeplasma laidlaw... 213 2e-53
ref|NP_469357.1| hypothetical protein lin0010 [Listeria inn... 213 3e-53
ref|YP_804427.1| Mevalonate kinase [Pediococcus pentosaceus... 212 3e-53
ref|NP_463543.1| hypothetical protein lmo0010 [Listeria mon... 211 8e-53
pdb|1KKH|A Chain A, Crystal Structure Of The Methanococcus ... 211 9e-53
ref|ZP_01544345.1| mevalonate kinase [Oenococcus oeni ATCC ... 211 1e-52
ref|NP_248080.1| mevalonate kinase [Methanocaldococcus jann... 211 1e-52
ref|ZP_01926008.1| mevalonate kinase [Listeria monocytogene... 211 1e-52
ref|YP_012624.1| mevalonate kinase [Listeria monocytogenes ... 210 1e-52
ref|YP_001581649.1| mevalonate kinase [Nitrosopumilus marit... 210 1e-52
ref|YP_810664.1| Mevalonate kinase [Oenococcus oeni PSU-1] ... 210 2e-52
ref|ZP_01942559.1| mevalonate kinase [Listeria monocytogene... 210 2e-52
ref|ZP_00604007.1| Mevalonate kinase [Enterococcus faecium ... 210 2e-52
ref|ZP_03980950.1| possible Mevalonate kinase [Enterococcus... 209 3e-52
ref|ZP_02689018.1| mevalonate kinase [Listeria monocytogene... 209 4e-52
ref|XP_802528.1| mevalonate kinase, putative [Trypanosoma c... 208 6e-52
ref|NP_720650.1| putative mevalonate kinase [Streptococcus ... 208 7e-52
ref|XP_814628.1| mevalonate kinase, putative [Trypanosoma c... 208 9e-52
ref|ZP_00230799.1| mevalonate kinase [Listeria monocytogene... 207 1e-51
ref|YP_001013073.1| Mevalonate kinase [Hyperthermus butylic... 207 2e-51
ref|NP_691146.1| mevalonate kinase [Oceanobacillus iheyensi... 206 2e-51
ref|ZP_01465063.1| mevalonate kinase [Stigmatella aurantiac... 205 4e-51
dbj|BAB07790.1| mevalonate kinase [Streptomyces sp. CL190] 203 2e-50
ref|YP_795031.1| Mevalonate kinase [Lactobacillus brevis AT... 203 3e-50
ref|YP_806709.1| Mevalonate kinase [Lactobacillus casei ATC... 200 2e-49
ref|YP_001274012.1| mevalonate kinase [Methanobrevibacter s... 200 2e-49
ref|XP_001325649.1| mevalonate kinase family protein [Trich... 199 5e-49
ref|ZP_03944901.1| possible mevalonate kinase [Lactobacillu... 195 5e-48
ref|YP_001844008.1| mevalonate kinase [Lactobacillus fermen... 195 5e-48
ref|NP_615566.1| mevalonate kinase [Methanosarcina acetivor... 194 1e-47
ref|ZP_01906658.1| mevalonate kinase [Plesiocystis pacifica... 193 3e-47
ref|YP_304960.1| mevalonate kinase [Methanosarcina barkeri ... 192 6e-47
dbj|BAD86800.1| mevalonate kinase [Streptomyces sp. KO-3988] 191 7e-47
ref|NP_645362.1| mevalonate kinase [Staphylococcus aureus s... 191 1e-46
ref|YP_040044.1| mevalonate kinase [Staphylococcus aureus s... 190 1e-46
gb|AAG02424.1|AF290087_1 mevalonate kinase [Staphylococcus ... 190 1e-46
gb|EAW97870.1| mevalonate kinase (mevalonic aciduria), isof... 190 2e-46
ref|YP_001435347.1| mevalonate kinase [Ignicoccus hospitali... 189 3e-46
sp|Q50559|KIME_METTH Mevalonate kinase (MK) >gi|1184118|gb|... 189 4e-46
ref|YP_633174.1| mevalonate kinase [Myxococcus xanthus DK 1... 188 7e-46
ref|NP_275189.1| mevalonate kinase [Methanothermobacter the... 187 2e-45
emb|CAL34097.1| putative mevalonate kinase [Streptomyces ci... 187 2e-45
ref|YP_001540788.1| mevalonate kinase [Caldivirga maquiling... 185 5e-45
ref|NP_819639.1| mevalonate kinase, putative [Coxiella burn... 184 1e-44
ref|NP_148611.1| mevalonate kinase [Aeropyrum pernix K1] >g... 183 2e-44
ref|YP_001030120.1| hypothetical protein Mlab_0681 [Methano... 183 3e-44
ref|YP_001096789.1| mevalonate kinase [Methanococcus maripa... 181 1e-43
ref|YP_001424028.1| putative phopshomevalonate kinase [Coxi... 180 1e-43
ref|YP_001614848.1| hypothetical protein sce4205 [Sorangium... 180 2e-43
ref|NP_614276.1| Mevalonate kinase [Methanopyrus kandleri A... 178 8e-43
ref|XP_001708461.1| Mevalonate kinase [Giardia lamblia ATCC... 177 1e-42
ref|YP_001329799.1| mevalonate kinase [Methanococcus maripa... 177 2e-42
dbj|BAE78977.1| mevalonate kinase [Streptomyces sp. KO-3988] 176 3e-42
ref|XP_001032429.2| DnaJ domain containing protein [Tetrahy... 176 4e-42
ref|XP_001458185.1| hypothetical protein GSPATT00003653001 ... 175 5e-42
ref|YP_001549383.1| mevalonate kinase [Methanococcus maripa... 174 1e-41
ref|NP_001022866.1| Y42G9A.4a [Caenorhabditis elegans] >gi|... 172 8e-41
ref|XP_001347016.1| Mevalonate kinase, putative [Paramecium... 169 4e-40
ref|NP_341921.1| Mevalonate kinase [Sulfolobus solfataricus... 169 4e-40
ref|XP_001666415.1| hypothetical protein CBG21109 [Caenorha... 168 9e-40
ref|YP_256937.1| mevalonate kinase [Sulfolobus acidocaldari... 168 1e-39
ref|NP_378182.1| hypothetical protein ST2185 [Sulfolobus to... 168 1e-39
ref|YP_001405370.1| mevalonate kinase [Candidatus Methanore... 165 8e-39
ref|YP_001191681.1| mevalonate kinase [Metallosphaera sedul... 164 1e-38
ref|NP_071114.1| mevalonate kinase (mvk) [Archaeoglobus ful... 162 4e-38
ref|YP_504301.1| mevalonate kinase [Methanospirillum hungat... 161 1e-37
ref|XP_001231562.1| PREDICTED: hypothetical protein [Gallus... 161 1e-37
ref|YP_001737496.1| mevalonate kinase [Candidatus Korarchae... 161 1e-37
ref|NP_371114.1| mevalonate kinase [Staphylococcus aureus s... 160 3e-37
ref|ZP_03852846.1| possible Galactokinase [Chryseobacterium... 156 3e-36
ref|NP_819638.1| phosphomevalonate kinase, putative [Coxiel... 153 2e-35
ref|ZP_01946351.1| mevalonate kinase [Coxiella burnetii 'MS... 152 6e-35
emb|CAF88123.1| unnamed protein product [Tetraodon nigrovir... 152 6e-35
ref|XP_001519270.1| PREDICTED: hypothetical protein, partia... 150 3e-34
ref|YP_001928600.1| putative galactokinase [Porphyromonas g... 148 1e-33
ref|NP_905758.1| galactokinase [Porphyromonas gingivalis W8... 147 1e-33
ref|ZP_03882650.1| mevalonate kinase [Haliangium ochraceum ... 146 3e-33
ref|XP_793882.1| PREDICTED: similar to mevalonate kinase va... 141 1e-31
ref|XP_001618047.1| hypothetical protein NEMVEDRAFT_v1g6609... 138 7e-31
gb|ABG24208.1| mevalonate kinase [Arnebia euchroma] 138 8e-31
gb|EDL19907.1| mevalonate kinase, isoform CRA_a [Mus muscul... 134 1e-29
gb|EDM13938.1| mevalonate kinase, isoform CRA_b [Rattus nor... 130 2e-28
gb|EDM13939.1| mevalonate kinase, isoform CRA_c [Rattus nor... 130 3e-28
Sequences not found previously or not previously below threshold:
ref|YP_395519.1| Mevalonate kinase [Lactobacillus sakei sub... 196 4e-48
ref|ZP_03959183.1| possible mevalonate kinase [Lactobacillu... 194 9e-48
ref|ZP_03913910.1| mevalonate kinase [Leuconostoc mesentero... 193 2e-47
ref|ZP_03845964.1| mevalonate kinase [Lactobacillus sakei s... 193 3e-47
ref|YP_818851.1| Mevalonate kinase [Leuconostoc mesenteroid... 193 3e-47
ref|ZP_03974667.1| mevalonate kinase [Lactobacillus reuteri... 192 7e-47
ref|YP_001271514.1| mevalonate kinase [Lactobacillus reuter... 189 6e-46
ref|ZP_03957037.1| mevalonate kinase [Lactobacillus ruminis... 187 1e-45
ref|ZP_01273283.1| Mevalonate kinase [Lactobacillus reuteri... 184 2e-44
ref|ZP_03808267.1| mevalonate kinase [Lactobacillus gasseri... 180 1e-43
ref|ZP_04008555.1| mevalonate kinase [Lactobacillus salivar... 180 2e-43
ref|YP_001727922.1| Mevalonate kinase [Leuconostoc citreum ... 179 3e-43
ref|YP_814846.1| Mevalonate kinase [Lactobacillus gasseri A... 179 3e-43
ref|NP_785308.1| mevalonate kinase [Lactobacillus plantarum... 179 5e-43
ref|ZP_03951014.1| mevalonate kinase [Lactobacillus gasseri... 178 7e-43
ref|YP_302212.1| mevalonate kinase [Staphylococcus saprophy... 178 8e-43
ref|ZP_03956255.1| mevalonate kinase [Lactobacillus jenseni... 176 2e-42
ref|YP_535578.1| Mevalonate kinase [Lactobacillus salivariu... 176 3e-42
ref|ZP_03807562.1| mevalonate kinase [Lactobacillus jenseni... 175 4e-42
ref|NP_988455.1| Mevalonate kinase [Methanococcus maripalud... 175 6e-42
ref|ZP_04007834.1| possible mevalonate kinase [Lactobacillu... 172 4e-41
ref|YP_254317.1| mevalonate kinase [Staphylococcus haemolyt... 171 8e-41
ref|YP_598349.1| Mevalonate kinase [Streptococcus pyogenes ... 171 9e-41
dbj|BAB07817.1| mevalonate kinase [Kitasatospora griseola] 171 1e-40
ref|NP_965060.1| mevalonate kinase [Lactobacillus johnsonii... 170 3e-40
gb|ABS50475.1| NapT6 [Streptomyces sp. CNQ525] 164 1e-38
gb|ABS50448.1| NapT6 [Streptomyces aculeolatus] 164 1e-38
ref|YP_139080.1| mevalonate kinase [Streptococcus thermophi... 163 2e-38
ref|YP_001034340.1| Mevalonate kinase, putative [Streptococ... 163 2e-38
dbj|BAD07375.1| mevalonate kinase [Actinoplanes sp. A40644] 163 2e-38
gb|ABH11598.1| GMP synthase, mevalonate kinase [Lactobacill... 163 3e-38
ref|YP_001577580.1| Mevalonate kinase [Lactobacillus helvet... 163 3e-38
ref|YP_820062.1| Mevalonate kinase [Streptococcus thermophi... 163 4e-38
ref|NP_688324.1| mevalonate kinase, putative [Streptococcus... 161 1e-37
ref|YP_140970.1| mevalonate kinase [Streptococcus thermophi... 160 2e-37
ref|NP_269075.1| mevalonate kinase [Streptococcus pyogenes ... 159 3e-37
ref|YP_001449558.1| mevalonate kinase [Streptococcus gordon... 158 5e-37
ref|YP_280130.1| mevalonate kinase [Streptococcus pyogenes ... 158 9e-37
ref|ZP_03996582.1| mevalonate kinase [Lactobacillus crispat... 158 1e-36
ref|NP_664399.1| mevalonate kinase [Streptococcus pyogenes ... 158 1e-36
ref|YP_060017.1| Mevalonate kinase [Streptococcus pyogenes ... 157 1e-36
ref|NP_607080.1| mevalonate kinase [Streptococcus pyogenes ... 157 2e-36
ref|YP_812921.1| Mevalonate kinase [Lactobacillus delbrueck... 157 2e-36
ref|ZP_02193921.1| mevalonate kinase [Methanococcus voltae ... 155 5e-36
ref|ZP_03859053.1| mevalonate kinase [Thermobaculum terrenu... 155 7e-36
ref|YP_001323164.1| mevalonate kinase [Methanococcus vannie... 155 1e-35
ref|YP_618979.1| Mevalonate kinase [Lactobacillus delbrueck... 155 1e-35
ref|YP_876537.1| mevalonate kinase [Cenarchaeum symbiosum A... 153 2e-35
ref|YP_001324970.1| mevalonate kinase [Methanococcus aeolic... 153 2e-35
gb|AAG02435.1|AF290091_1 mevalonate kinase [Staphylococcus ... 153 2e-35
ref|YP_187834.1| mevalonate kinase [Staphylococcus epidermi... 153 4e-35
ref|ZP_01817104.1| mevalonate kinase [Streptococcus pneumon... 150 2e-34
ref|YP_002741922.1| mevalonate kinase [Streptococcus pneumo... 149 4e-34
ref|ZP_02919501.1| hypothetical protein STRINF_00343 [Strep... 148 8e-34
gb|AAG02455.1|AF290099_1 mevalonate kinase [Streptococcus p... 148 9e-34
ref|ZP_02710031.1| mevalonate kinase [Streptococcus pneumon... 146 3e-33
ref|NP_344908.1| mevalonate kinase [Streptococcus pneumonia... 146 3e-33
ref|ZP_01819603.1| mevalonate kinase [Streptococcus pneumon... 146 4e-33
ref|YP_002735468.1| mevalonate kinase [Streptococcus pneumo... 146 5e-33
ref|YP_001153805.1| mevalonate kinase [Pyrobaculum arsenati... 145 5e-33
ref|NP_560495.1| mevalonate kinase [Pyrobaculum aerophilum ... 145 7e-33
ref|ZP_03937041.1| possible mevalonate kinase [Gardnerella ... 145 8e-33
ref|YP_001851498.1| mevalonate kinase, Erg12 [Mycobacterium... 143 2e-32
ref|YP_001795021.1| mevalonate kinase [Thermoproteus neutro... 143 3e-32
ref|YP_001056718.1| mevalonate kinase [Pyrobaculum calidifo... 143 3e-32
ref|YP_194037.1| mevalonate kinase [Lactobacillus acidophil... 143 3e-32
ref|NP_357932.1| Mevalonate kinase [Streptococcus pneumonia... 142 6e-32
ref|YP_929988.1| mevalonate kinase [Pyrobaculum islandicum ... 142 7e-32
ref|XP_001423293.1| hypothetical protein GSPATT00000330001 ... 140 3e-31
ref|YP_907150.1| mevalonate kinase, Erg12 [Mycobacterium ul... 136 3e-30
ref|YP_001047720.1| mevalonate kinase [Methanoculleus maris... 136 4e-30
ref|ZP_03845548.1| mevalonate kinase [Lactobacillus sakei s... 135 8e-30
ref|YP_118418.1| putative mevalonate kinase [Nocardia farci... 132 5e-29
ref|ZP_02069938.1| hypothetical protein BACUNI_01355 [Bacte... 132 8e-29
ref|YP_098935.1| galactokinase [Bacteroides fragilis YCH46]... 131 1e-28
ref|ZP_01960689.1| hypothetical protein BACCAC_02307 [Bacte... 131 1e-28
emb|CAD24422.1| phosphomevalonate kinase [Paracoccus zeaxan... 130 2e-28
ref|ZP_00780842.1| mevalonate kinase [Streptococcus agalact... 130 3e-28
ref|ZP_02435601.1| hypothetical protein BACSTE_01848 [Bacte... 129 5e-28
ref|ZP_01059235.1| galactokinase [Flavobacterium sp. MED217... 129 5e-28
ref|YP_001540410.1| GHMP kinase [Caldivirga maquilingensis ... 128 6e-28
ref|YP_001299606.1| galactokinase [Bacteroides vulgatus ATC... 128 1e-27
ref|ZP_02064749.1| hypothetical protein BACOVA_01718 [Bacte... 128 1e-27
>gb|EDN64144.1| mevalonate kinase [Saccharomyces cerevisiae YJM789]
Length = 443
Score = 648 bits (1673), Expect = 0.0, Method: Composition-based stats.
Identities = 442/443 (99%), Positives = 442/443 (99%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFN 60
MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFN
Sbjct: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFN 60
Query: 61 HKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLY 120
HKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLY
Sbjct: 61 HKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLY 120
Query: 121 MFVCLCPHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLIGSNDLEKLSENDK 180
MFVCLCPHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLIGSNDLEKLSENDK
Sbjct: 121 MFVCLCPHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLIGSNDLEKLSENDK 180
Query: 181 HIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLDDFPAIPMI 240
HIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLDDFPAIPMI
Sbjct: 181 HIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLDDFPAIPMI 240
Query: 241 LTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSKCKGTDDEA 300
LTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSKCKGTDDEA
Sbjct: 241 LTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSKCKGTDDEA 300
Query: 301 VETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGAGGGGCSLT 360
VETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGAGGGGCSLT
Sbjct: 301 VETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGAGGGGCSLT 360
Query: 361 LLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLNKDLKIKSLVFQLFEN 420
LLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLNKD KIKSLVFQLFEN
Sbjct: 361 LLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLNKDPKIKSLVFQLFEN 420
Query: 421 KTTTKQQIDDLLLPGNTNLPWTS 443
KTTTKQQIDDLLLPGNTNLPWTS
Sbjct: 421 KTTTKQQIDDLLLPGNTNLPWTS 443
>ref|NP_013935.1| Mevalonate kinase, acts in the biosynthesis of isoprenoids and
sterols, including ergosterol, from mevalonate; Erg12p
[Saccharomyces cerevisiae]
sp|P07277|KIME_YEAST Mevalonate kinase (MK) (MvK)
emb|CAA39359.1| mevalonate kinase [Saccharomyces cerevisiae]
emb|CAA29487.1| unnamed protein product [Saccharomyces cerevisiae]
emb|CAA89923.1| Rar1p [Saccharomyces cerevisiae]
Length = 443
Score = 648 bits (1673), Expect = 0.0, Method: Composition-based stats.
Identities = 443/443 (100%), Positives = 443/443 (100%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFN 60
MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFN
Sbjct: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFN 60
Query: 61 HKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLY 120
HKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLY
Sbjct: 61 HKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLY 120
Query: 121 MFVCLCPHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLIGSNDLEKLSENDK 180
MFVCLCPHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLIGSNDLEKLSENDK
Sbjct: 121 MFVCLCPHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLIGSNDLEKLSENDK 180
Query: 181 HIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLDDFPAIPMI 240
HIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLDDFPAIPMI
Sbjct: 181 HIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLDDFPAIPMI 240
Query: 241 LTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSKCKGTDDEA 300
LTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSKCKGTDDEA
Sbjct: 241 LTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSKCKGTDDEA 300
Query: 301 VETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGAGGGGCSLT 360
VETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGAGGGGCSLT
Sbjct: 301 VETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGAGGGGCSLT 360
Query: 361 LLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLNKDLKIKSLVFQLFEN 420
LLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLNKDLKIKSLVFQLFEN
Sbjct: 361 LLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLNKDLKIKSLVFQLFEN 420
Query: 421 KTTTKQQIDDLLLPGNTNLPWTS 443
KTTTKQQIDDLLLPGNTNLPWTS
Sbjct: 421 KTTTKQQIDDLLLPGNTNLPWTS 443
>ref|XP_001644409.1| hypothetical protein Kpol_1064p33 [Vanderwaltozyma polyspora DSM
70294]
gb|EDO16551.1| hypothetical protein Kpol_1064p33 [Vanderwaltozyma polyspora DSM
70294]
Length = 421
Score = 455 bits (1172), Expect = e-126, Method: Composition-based stats.
Identities = 244/441 (55%), Positives = 326/441 (73%), Gaps = 23/441 (5%)
Query: 2 SLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFNH 61
+PF+TSAPGKVIIFGEHSAVYN+PAVAASVS+LRT+LL+ + + DT+ L+FPDI F+H
Sbjct: 1 MIPFITSAPGKVIIFGEHSAVYNEPAVAASVSSLRTFLLVEDGAHRDTVALNFPDIKFHH 60
Query: 62 KWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDP-LLAQLSESFHYHAAFCFLY 120
+W ++ + + + L KA++ T+ LSQ LV+LL+ LL L ES H+HAAFCF+Y
Sbjct: 61 EWRHSEIHQVIKLAEADGLLTKARKDTNNLSQPLVTLLEEKLLGSLKESLHFHAAFCFIY 120
Query: 121 MFVCLCPHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLIGSNDLEKLSENDK 180
++VCLCP+ ++KFSLKSTLPIGAGLGSSASISV+L+LAMA LGG I S + L+ DK
Sbjct: 121 LYVCLCPNVNHVKFSLKSTLPIGAGLGSSASISVALSLAMAKLGGHIKSTE--SLTSADK 178
Query: 181 HIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLDDFPAIPMI 240
+N W+FIGEKCIHGTPSGIDNAVATYGNA+LF+K+ + + NF+F+D+FP IPMI
Sbjct: 179 KYINSWSFIGEKCIHGTPSGIDNAVATYGNAVLFKKEDNG----STNFQFIDNFPKIPMI 234
Query: 241 LTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSKCKGTDDEA 300
LTYTRIPRSTK LV+ VR LV EK+P + KPIL +MG A G +I+ L
Sbjct: 235 LTYTRIPRSTKVLVSNVRELV-EKYPSIFKPILQSMGHLANDGADILRNL---------- 283
Query: 301 VETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGAGGGGCSLT 360
N++ Y LLEL+R+NHGLLVS+GVSHPGLE+IK+LSD + +GSTKLTGAGGGGCSLT
Sbjct: 284 ---NDKNYNDLLELVRVNHGLLVSLGVSHPGLEIIKSLSDTMDLGSTKLTGAGGGGCSLT 340
Query: 361 LLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLNKDLKIKSLVFQLFEN 420
+L++D+TQ+QI +FK L++ +Y T++TDLGG GC +S ++ + I ++ + E
Sbjct: 341 ILKKDVTQDQIKTFKSILKEKHNYGTYDTDLGGMGCSFVSLDSIPEKDAI--VIKAILEA 398
Query: 421 KTTTKQQIDDLLLPGNTNLPW 441
+ + ++Q+ L + L W
Sbjct: 399 RESPREQLTKFLFSDESVLTW 419
>ref|NP_985191.1| AER335Wp [Ashbya gossypii ATCC 10895]
gb|AAS53015.1| AER335Wp [Ashbya gossypii ATCC 10895]
Length = 428
Score = 440 bits (1133), Expect = e-122, Method: Composition-based stats.
Identities = 210/440 (47%), Positives = 291/440 (66%), Gaps = 29/440 (6%)
Query: 3 LPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFNHK 62
LPF+TSAPGKVIIFGEHSAVYNKPA+AASVS+LRTYL + + D + ++FPDI F +
Sbjct: 14 LPFITSAPGKVIIFGEHSAVYNKPAIAASVSSLRTYLFVEADAESDAVRMEFPDIGFQYS 73
Query: 63 WSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLYMF 122
W A+ + V ++ L E+++ +D LL L + HAA CFLY++
Sbjct: 74 WKHEALTAVPREAVVRAFCSR------ELDAEVLAHVDRLLMGLEGALARHAALCFLYIY 127
Query: 123 VCLCPHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLIGSNDLEKLSENDKHI 182
CLC + ++F++KSTLPIGAGLGSSASI+V LALAM LGG + + L++ +
Sbjct: 128 TCLCREVQGVRFTVKSTLPIGAGLGSSASIAVCLALAMGRLGGHVQC-ESGALTKEQQDF 186
Query: 183 VNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLDDFPAIPMILT 242
VN+WA +GE+CIHGTPSGIDNAVATYG+A+LF++ + F L DFP +PMILT
Sbjct: 187 VNRWALVGEQCIHGTPSGIDNAVATYGDAVLFQRQPDG----STKFDHLSDFPQMPMILT 242
Query: 243 YTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSKCKGTDDEAVE 302
T++P+STK LVA V LV E+ P + PIL+ M + Q E++ ++
Sbjct: 243 NTKVPKSTKVLVANVGKLV-EQEPLITAPILNTMAQVVTQAHELL-----------PLLQ 290
Query: 303 TNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGAGGGGCSLTLL 362
++ +Y +LL+L+RINHGLLV++GVSHP LE ++ L D L IG+TKLTGAGGGGC+LTLL
Sbjct: 291 GDDTVYTRLLQLVRINHGLLVALGVSHPSLEHVRALCDTLGIGATKLTGAGGGGCALTLL 350
Query: 363 RRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLNKDL-KIKSLVFQLFENK 421
+RD+ E ++ F+K L D YE+F T LGG GCCL +++ + L +IK+L +
Sbjct: 351 KRDVEDELVEQFRKTLLDKHGYESFTTGLGGVGCCLATSQTIRPHLDRIKTLF-----QE 405
Query: 422 TTTKQQIDDLLLPGNTNLPW 441
T +QQ+ + LLPG + + W
Sbjct: 406 DTPQQQLAEALLPGASPIDW 425
>ref|XP_001229023.1| hypothetical protein CHGG_02507 [Chaetomium globosum CBS 148.51]
gb|EAQ90572.1| hypothetical protein CHGG_02507 [Chaetomium globosum CBS 148.51]
Length = 532
Score = 432 bits (1111), Expect = e-119, Method: Composition-based stats.
Identities = 163/411 (39%), Positives = 245/411 (59%), Gaps = 28/411 (6%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISE-SSAPDTIELDFPDISF 59
M F+ SAPGKVI+FGEHS V+ K A+AA++S LR+YLL++ S + T+ L FPDI F
Sbjct: 82 MMPAFMVSAPGKVIVFGEHSVVHGKAAIAAAIS-LRSYLLVTTLSKSKRTVTLKFPDIDF 140
Query: 60 NHKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLS-------ESFHY 112
+H W+I++ T Q + +K + L ELV+ + P LA +S H
Sbjct: 141 DHCWNIDELPWATFQQPSKKKYYYS--LVTELDPELVAAIQPFLANVSPDKPAGIRKVHQ 198
Query: 113 HAAFCFLYMFVCLCPHA-KNIKFSLKSTLPIGAGLGSSASISVSLALA-MAYLGGLIGSN 170
++A FLYMF+ L + +++L+ST+PIGAGLGSSA+I+V ++ A + L L G +
Sbjct: 199 NSAGSFLYMFLSLGSQSFPGCQYTLRSTIPIGAGLGSSATIAVCMSAALLLQLRTLAGPH 258
Query: 171 DLEKLSENDKHI--VNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNF 228
+ E I +N+WA++ E IHG PSG+DN VAT G A++F++ + +
Sbjct: 259 PDQPADEARMQIERINRWAYVYEMFIHGNPSGVDNTVATQGKAVVFQRTDYG---KPPSV 315
Query: 229 KFLDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMT 288
+ L DFP +P++L TR+P+ST VA+V L P ++ ILDAM + A E++T
Sbjct: 316 RPLWDFPELPLLLVDTRVPKSTAHEVAKVGKL-KNTHPVLVGSILDAMDKVADASAEVLT 374
Query: 289 KLSKCKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTK 348
+ + + ++ EL+ +NHGLLVS+GVSHP LE ++ L D IG TK
Sbjct: 375 E--------EGFDTQSEASLARVGELMTVNHGLLVSLGVSHPRLERVRELVDHEGIGWTK 426
Query: 349 LTGAGGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLL 399
LTGAGGGGC +TLL+ + ++++ + +L D+ +E FET LGG G +L
Sbjct: 427 LTGAGGGGCCITLLKPGVERKKLRKLQAQL-DEEGFEKFETTLGGDGVGVL 476
>ref|XP_446138.1| unnamed protein product [Candida glabrata]
emb|CAG59062.1| unnamed protein product [Candida glabrata CBS 138]
Length = 430
Score = 431 bits (1109), Expect = e-119, Method: Composition-based stats.
Identities = 240/448 (53%), Positives = 310/448 (69%), Gaps = 35/448 (7%)
Query: 3 LPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISE--SSAPDTIELDFPDISFN 60
LPFL SAPGKVI+FGEHSAVYN+PAVAASVS+LRTYLL+S S+A D+IEL FPDI F+
Sbjct: 7 LPFLVSAPGKVILFGEHSAVYNEPAVAASVSSLRTYLLVSPAGSNAEDSIELSFPDIGFD 66
Query: 61 HKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLY 120
H W + + + + L A++ T L++ELV LL+ +L L ES HYHAAFCFLY
Sbjct: 67 HVWKRKELEPVLRE---TALLQAAREDTKNLNEELVGLLNVILEPLKESLHYHAAFCFLY 123
Query: 121 MFVCLCPHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLIGSNDLEKLSENDK 180
+F LCP A NIKFS+KSTLPIGAGLGSSA+ISVSLA+AM LGG + + + LS DK
Sbjct: 124 LFCTLCPSATNIKFSVKSTLPIGAGLGSSAAISVSLAMAMLRLGGKLVTGE--SLSGEDK 181
Query: 181 HIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLDDFPAI--P 238
++N+WAFIGEKCIHGTPSGIDNAVATYGNA+LF++ + T +F+FLD F + P
Sbjct: 182 ALINEWAFIGEKCIHGTPSGIDNAVATYGNAVLFKRSADG----TTDFEFLDKFHELKIP 237
Query: 239 MILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSKCKGTDD 298
M+LTYTRIPRSTK LV+ VR L + + ++ AMGE AL+ ++I+
Sbjct: 238 MVLTYTRIPRSTKVLVSSVRDLSNKYPKVIQDHVIKAMGELALESVDILNS--------- 288
Query: 299 EAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGAGGGGCS 358
+ N+ YE+LL+L+ INHGLLV+IGVSHPGLE+I+NLS IG+TKLTGAGGGGC+
Sbjct: 289 -GIGGNDSNYERLLDLVNINHGLLVAIGVSHPGLEIIRNLSITNSIGATKLTGAGGGGCA 347
Query: 359 LTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCL---LSAKNLNKDLKIKSLVF 415
T+L +D+ Q ++D FK++L Y +F ++LGG G C+ L A+ N LV
Sbjct: 348 FTVLNKDVPQTEVDKFKEELSKKHGYLSFTSELGGAGSCMTPTLVAEQYN-------LVA 400
Query: 416 QLFENKTTTKQQIDDLLLPGNT--NLPW 441
LFEN K+++D LLP +L W
Sbjct: 401 PLFENTENNKEELDKTLLPATATNSLFW 428
>ref|XP_001593159.1| hypothetical protein SS1G_06081 [Sclerotinia sclerotiorum 1980]
gb|EDO03600.1| hypothetical protein SS1G_06081 [Sclerotinia sclerotiorum 1980]
Length = 473
Score = 429 bits (1104), Expect = e-118, Method: Composition-based stats.
Identities = 172/411 (41%), Positives = 246/411 (59%), Gaps = 30/411 (7%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISE-SSAPDTIELDFPDISF 59
M PF+ SAPGKVI+FGEH+ V+ KPA+AA++S LR+YLL++ S + TI L FPDI+
Sbjct: 26 MMPPFMVSAPGKVIVFGEHAVVHGKPAIAAAIS-LRSYLLVTALSKSKRTISLRFPDINL 84
Query: 60 NHKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLS-------ESFHY 112
+H W+I+D T + +K Q L ELV+ + P L +S H
Sbjct: 85 SHTWNIDDLPWSTFSHPSKKKYYYDQ--VTSLDPELVAAMKPHLENISPDESPSIRKIHQ 142
Query: 113 HAAFCFLYMFVCLCPHA-KNIKFSLKSTLPIGAGLGSSASISVSLALA-MAYLGGLIGSN 170
+A FLY+F+ L + ++L+ST+PIGAGLGSSASISV L+ A + + L G +
Sbjct: 143 SSASSFLYIFLSLGSQSFPGCLYTLRSTIPIGAGLGSSASISVCLSSALLLQIRTLSGPH 202
Query: 171 DLEKLSENDKHI--VNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNF 228
+ +E + +N+WAF+GE CIHG PSG+DN V+T G A++++K T+
Sbjct: 203 PDQPSNEASLQLERINRWAFVGEMCIHGNPSGVDNTVSTQGKAVIYQKFPEGPTV----- 257
Query: 229 KFLDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMT 288
K L DFP +P++L T+ +ST VA+V L+ EK P ++ ILDA+ ++
Sbjct: 258 KPLRDFPELPLLLVDTQQAKSTAHEVAKVG-LLKEKHPAIVDSILDAID--------MVG 308
Query: 289 KLSKCKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTK 348
+ + +D N E E L +L+ INHGLLVS+GVSHP LE I+ L D IG TK
Sbjct: 309 QSAAAMISDPNYDSENIECVESLGKLMTINHGLLVSLGVSHPRLERIRELVDHEGIGWTK 368
Query: 349 LTGAGGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLL 399
LTGAGGGGCS+TLL+ D T E++ + L+++ Y+ FET LG G +L
Sbjct: 369 LTGAGGGGCSITLLKPDTTPERMARLEATLENE-GYKKFETTLGCDGVGVL 418
>ref|XP_001911734.1| unnamed protein product [Podospora anserina]
emb|CAP73562.1| unnamed protein product [Podospora anserina]
Length = 528
Score = 428 bits (1101), Expect = e-118, Method: Composition-based stats.
Identities = 164/411 (39%), Positives = 247/411 (60%), Gaps = 28/411 (6%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISE-SSAPDTIELDFPDISF 59
M F+ SAPGKVI+FGEH+ V+ K A+AAS+ ALR+YLL++ S + T+ L FPDI F
Sbjct: 73 MMPSFMVSAPGKVIVFGEHAVVHGKAAIAASI-ALRSYLLVTSLSKSRKTVTLKFPDIDF 131
Query: 60 NHKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLS-------ESFHY 112
+H W I++ Q + +K + + QELV+ + P LA +S H
Sbjct: 132 DHSWRIDELPWAIFQQPSKKKYYYS--LVTEIDQELVAAIQPYLADVSPDKPADVRKVHQ 189
Query: 113 HAAFCFLYMFVCLCPHA-KNIKFSLKSTLPIGAGLGSSASISVSLALAMA-YLGGLIGSN 170
++A FLYMF+ L + +++L+ST+PIGAGLGSSA+I+V L+ A+ L L G +
Sbjct: 190 NSAGSFLYMFLSLGSQSFPACQYTLRSTIPIGAGLGSSATIAVCLSAALLLQLRTLSGPH 249
Query: 171 DLEKLSENDKHI--VNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNF 228
+ E I +N+WA++ E IHG PSG+DN V+T G A++F++ ++ +
Sbjct: 250 PDQPPEEARMQIERINRWAYVYEMFIHGNPSGVDNTVSTQGKAVMFQRTDYS---KAPDV 306
Query: 229 KFLDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMT 288
K L DFP +P++L TR P+ST VA+V L + P+++ ILDA+ + E++
Sbjct: 307 KPLWDFPELPLLLVDTRTPKSTAHEVAKVGRL-KDTHPKLVGSILDAIDKVTQTSAELIA 365
Query: 289 KLSKCKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTK 348
+ D+ + ++ EL+ INHGLLVS+GVSHP LE ++ L D IG TK
Sbjct: 366 E--------DDFSTEKEDSLRRVGELMNINHGLLVSLGVSHPRLERVRELVDHQGIGWTK 417
Query: 349 LTGAGGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLL 399
LTGAGGGGCS+TLL+ + +E++ +++L D+ Y+ FET LGG G +L
Sbjct: 418 LTGAGGGGCSITLLKPGVPREKLARLEEQL-DEEGYQRFETTLGGDGVGVL 467
>ref|XP_452532.1| unnamed protein product [Kluyveromyces lactis]
emb|CAH01383.1| unnamed protein product [Kluyveromyces lactis NRRL Y-1140]
Length = 419
Score = 424 bits (1090), Expect = e-117, Method: Composition-based stats.
Identities = 225/441 (51%), Positives = 297/441 (67%), Gaps = 32/441 (7%)
Query: 4 PFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFNHKW 63
PF+ SAPGKVIIFGEHSAV+NK A+AASVS+LRTYLLI +S D +ELDFPDI+++ KW
Sbjct: 10 PFIVSAPGKVIIFGEHSAVFNKNAIAASVSSLRTYLLIEQSKDGDGVELDFPDINYDSKW 69
Query: 64 SINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLYMFV 123
S + I + V K L +L L+ LL L +S +Y+AA FLY+++
Sbjct: 70 STEELKTIDSEVV------KQAAGLKHLCPKLKEQLNLLLEGLKDSLNYYAALSFLYLYL 123
Query: 124 CLCPHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLIGSNDLEKLSENDKHIV 183
LCP+ K +KF++KSTLPIGAGLGSSASISV LALAMA +GG I + + +S+ +K +
Sbjct: 124 SLCPNVKGLKFTVKSTLPIGAGLGSSASISVCLALAMARMGGHISCD--KSISQEEKEFI 181
Query: 184 NQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLDDFPAIPMILTY 243
N WAFIGE CIHGTPSGIDNAVATYGNA+ F++ + F + +FP +PM+LT
Sbjct: 182 NHWAFIGECCIHGTPSGIDNAVATYGNAVKFKRQEDG----STKFDQISNFPQLPMVLTN 237
Query: 244 TRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSKCKGTDDEAVET 303
TRI RSTK LV+ V LV K P + +PIL+AM + AL+G E+++ +SK
Sbjct: 238 TRIKRSTKILVSGVGDLVNRK-PLITEPILEAMNQVALRGSELLSDISK----------- 285
Query: 304 NNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGAGGGGCSLTLLR 363
+ Y++LLELIRINHGLLV+IGVSHPGLE+IK LSD+L+IG TKLTGAGGGGC+ TLL
Sbjct: 286 -DIHYDELLELIRINHGLLVAIGVSHPGLEVIKQLSDELKIGQTKLTGAGGGGCAFTLLN 344
Query: 364 RDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLNKDLKIKSLVFQLFENKTT 423
+D+ + F +KL ++ Y+ FET LGG GCC + KN + +K L +
Sbjct: 345 KDVDHSSVRKFHEKLHSNYGYQIFETGLGGVGCCFVDLKNEQYE-SLKHLFID-----SA 398
Query: 424 TKQQIDDLLLPG-NTNLPWTS 443
T Q++ LLP + +L WT+
Sbjct: 399 TVQEVSLALLPSPDGSLTWTA 419
>ref|XP_386088.1| hypothetical protein FG05912.1 [Gibberella zeae PH-1]
Length = 508
Score = 423 bits (1087), Expect = e-116, Method: Composition-based stats.
Identities = 166/411 (40%), Positives = 241/411 (58%), Gaps = 28/411 (6%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISE-SSAPDTIELDFPDISF 59
M+ PF+ SAPGKVI+FGEHS V+ K A+AA++S LR+YL ++ S + T+ L F DI
Sbjct: 57 MAPPFMVSAPGKVIVFGEHSVVHGKAAIAAAIS-LRSYLHVTTLSKSKRTVSLRFADIGL 115
Query: 60 NHKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLS-------ESFHY 112
H W+I D Q + +K + L +LV+ + P + +S H+
Sbjct: 116 VHTWNIEDLPWEAFQQPSKKKSYYS--LVTELDPDLVAAIQPHIEVVSPNHPEEIRRVHH 173
Query: 113 HAAFCFLYMFVCL-CPHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMA-YLGGLIGSN 170
+ FLY+F+ L P ++L+ST+PIGAGLGSSAS+SV LA A+ L L G +
Sbjct: 174 SSVSAFLYLFLSLGSPSFPPCLYTLRSTIPIGAGLGSSASVSVCLASALLLQLRTLSGPH 233
Query: 171 DLEKLSENDK--HIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNF 228
+ E +N+WAF+ E CIHG PSG+DN VAT G A++F++ ++ N
Sbjct: 234 PDQPADEARLQVERINRWAFVSEMCIHGNPSGVDNTVATQGKAVVFQRTDYS---KPPNV 290
Query: 229 KFLDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMT 288
+ L DFP +P++L TR +ST VA+V L + P+++ ILDAM + E++
Sbjct: 291 RPLWDFPELPLLLVDTRQAKSTAHEVAKVAKL-KQTHPKLVNSILDAMDKVTDAASELIE 349
Query: 289 KLSKCKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTK 348
+ S G + E ++ EL+ INHGLLVS+GVSHP LE ++ L D IG TK
Sbjct: 350 ETSFDNG--------SVEDLSKVGELMTINHGLLVSLGVSHPRLERVRELVDHEGIGWTK 401
Query: 349 LTGAGGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLL 399
LTGAGGGGCS+TLLR D+ E++ +++L+ + +Y FET LGG G +L
Sbjct: 402 LTGAGGGGCSITLLRPDVPAEKLQKLEERLETE-NYAKFETTLGGDGIGVL 451
>ref|XP_001271672.1| mevalonate kinase [Aspergillus clavatus NRRL 1]
gb|EAW10246.1| mevalonate kinase [Aspergillus clavatus NRRL 1]
Length = 536
Score = 421 bits (1083), Expect = e-116, Method: Composition-based stats.
Identities = 158/411 (38%), Positives = 235/411 (57%), Gaps = 28/411 (6%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISE-SSAPDTIELDFPDISF 59
M+ F+ SAPGKVI++GEH+ V+ K A+AA++S LR+YLL++ S + T+ ++F DI
Sbjct: 85 MAPAFMVSAPGKVIVYGEHAVVHGKAAMAAAIS-LRSYLLVTTLSKSQRTVTMNFRDIGL 143
Query: 60 NHKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLS-------ESFHY 112
+H W+I+D + +K L ELV + P + +S H
Sbjct: 144 DHTWNIDDLPWDVFHHPSKKKFY--YNLVTSLDPELVDAIQPHVDAVSPDKPEDVRKIHR 201
Query: 113 HAAFCFLYMFVCL-CPHAKNIKFSLKSTLPIGAGLGSSASISVSLALA-MAYLGGLIGSN 170
+A FLY+F+ L P ++L+ST+PIGAGLGSSAS+ V L+ A + + L G +
Sbjct: 202 RSASAFLYLFLSLGSPQTPGAIYTLRSTIPIGAGLGSSASVCVCLSAALLLQIRTLAGPH 261
Query: 171 DLEKLSENDKHI--VNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNF 228
+ E + I +N+WAF+GE C HG PSG+DN V+ G A++F ++ +
Sbjct: 262 PDQPPDEAETQIERINRWAFVGEMCTHGNPSGVDNTVSAGGKAVIFRREDYT---KPPTV 318
Query: 229 KFLDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMT 288
L +FP +P++L TR RST VA+V L + P V + ILDA+ + L E +
Sbjct: 319 IPLPNFPELPLLLVDTRQARSTAAEVAKVGKL-KDDHPVVTEAILDAIDKVTLAAQEAIQ 377
Query: 289 KLSKCKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTK 348
++ + ++ E L LIRINHG LVS+GVSHP LE I+ L D IG TK
Sbjct: 378 DINSKGVSA--------QILEHLGTLIRINHGFLVSLGVSHPRLERIRELVDYANIGWTK 429
Query: 349 LTGAGGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLL 399
LTGAGGGGC++T+LR D+ +E + ++KL + +E +ET LGG G +L
Sbjct: 430 LTGAGGGGCAITVLRPDVKEEAVRDLEQKLSVE-GFEKYETTLGGDGIGVL 479
>ref|XP_661473.1| hypothetical protein AN3869.2 [Aspergillus nidulans FGSC A4]
gb|EAA59134.1| hypothetical protein AN3869.2 [Aspergillus nidulans FGSC A4]
Length = 735
Score = 421 bits (1083), Expect = e-116, Method: Composition-based stats.
Identities = 158/411 (38%), Positives = 236/411 (57%), Gaps = 28/411 (6%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISE-SSAPDTIELDFPDISF 59
++ F+ SAPGKVI++GEH+ V+ K A+AA++S LR+YLL++ S + TI L+F D +
Sbjct: 287 LAPAFMVSAPGKVIVYGEHAVVHGKAAMAAAIS-LRSYLLVTTLSKSQRTITLNFRDTNL 345
Query: 60 NHKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLS-------ESFHY 112
NH W I+ + +K L QEL + P + +S H
Sbjct: 346 NHTWDIDQLPWDLFHHPSKKKYY--YDLVTTLDQELYDAIQPHVEDISPDAPEEMRKIHK 403
Query: 113 HAAFCFLYMFVCL-CPHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMA-YLGGLIGSN 170
+A FLY+F+ L P + ++L+ST+PIGAGLGSSAS+ V ++ A+ + L G +
Sbjct: 404 RSASAFLYLFLSLGSPQSAGAIYTLRSTIPIGAGLGSSASVCVCMSAALLVQIRTLAGPH 463
Query: 171 DLEKLSENDKHI--VNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNF 228
+ E + I +N+WAF+GE CIHG PSG+DN V+ G A++F + ++ + +
Sbjct: 464 PDQPPDEAEVQIERINRWAFVGEMCIHGNPSGVDNTVSAGGKAVIFRRGDYSKPPSVTS- 522
Query: 229 KFLDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMT 288
L FP +P++L TR RST VA+V L E +P V + ILDA+ +++
Sbjct: 523 --LPTFPELPLLLVDTRQGRSTAVEVAKVGALRKE-WPVVTESILDAIDNVTASAEKVIR 579
Query: 289 KLSKCKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTK 348
+ + + + +QL LIRINHG LVS+GVSHP LE I+ L D IG TK
Sbjct: 580 EPNPEGL--------SEKTLQQLGTLIRINHGFLVSLGVSHPRLERIRELVDYADIGWTK 631
Query: 349 LTGAGGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLL 399
LTGAGGGGC++TLLR D+ + + K +LQD+ ++ +ET LGG G +L
Sbjct: 632 LTGAGGGGCAITLLRPDLNDDSLRQLKSQLQDE-NFGIYETTLGGDGVGVL 681
>ref|XP_961360.1| hypothetical protein NCU03633 [Neurospora crassa OR74A]
emb|CAC28692.1| related to MEVALONATE KINASE [Neurospora crassa]
gb|EAA32124.1| hypothetical protein NCU03633 [Neurospora crassa OR74A]
Length = 528
Score = 421 bits (1082), Expect = e-116, Method: Composition-based stats.
Identities = 166/411 (40%), Positives = 246/411 (59%), Gaps = 28/411 (6%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLI-SESSAPDTIELDFPDISF 59
M F+ SAPGKVI+FGEH+ V+ K A+AA++S LR+YLL+ + S + T+ L FPDI F
Sbjct: 76 MMPTFMVSAPGKVIVFGEHAVVHGKAAIAAAIS-LRSYLLVNTLSKSKRTVTLKFPDIDF 134
Query: 60 NHKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLS-------ESFHY 112
NH W+I++ Q +K + + QELV + P LA +S H
Sbjct: 135 NHSWNIDELPWKIFQQPGKKKYYYS--LVTEIDQELVDAVQPFLADVSIDKPADIRKVHQ 192
Query: 113 HAAFCFLYMFVCLCPHA-KNIKFSLKSTLPIGAGLGSSASISVSLALAMA-YLGGLIGSN 170
++A FLYMF+ L + +++L+ST+PIGAGLGSSA+I+V L+ A+ L L G +
Sbjct: 193 NSAGSFLYMFLSLGSQSFPGCQYTLRSTIPIGAGLGSSATIAVCLSAALLLQLRTLSGPH 252
Query: 171 DLEKLSENDKHI--VNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNF 228
+ E I +N+WAF+ E IHG PSG+DN V+T G A++F++ +N +
Sbjct: 253 PDQPPEEARLQIERINRWAFVYEMFIHGNPSGVDNTVSTQGKAVVFQRTDYNQP---PSV 309
Query: 229 KFLDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMT 288
+ L DFP +P++L TR +ST VA+V L K P+++ IL A+ + +++
Sbjct: 310 RPLWDFPKLPLLLVDTRTAKSTAHEVAKVATLKK-KHPQLVGTILTAIDQVTQSSAQLIE 368
Query: 289 KLSKCKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTK 348
+ + T+DE E ++ E++ INHGLLVS+GVSHP LE ++ L D IG TK
Sbjct: 369 E--QGFNTEDE------ESLSKVGEMMTINHGLLVSLGVSHPRLERVRELVDHEGIGWTK 420
Query: 349 LTGAGGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLL 399
LTGAGGGGCS+TLLR + +E++D +++L D+ Y FET LG G +L
Sbjct: 421 LTGAGGGGCSITLLRPGVPREKLDKLEQRL-DEEGYSKFETTLGSDGVGVL 470
>ref|XP_001559870.1| hypothetical protein BC1G_01429 [Botryotinia fuckeliana B05.10]
gb|EDN27159.1| hypothetical protein BC1G_01429 [Botryotinia fuckeliana B05.10]
Length = 498
Score = 420 bits (1081), Expect = e-116, Method: Composition-based stats.
Identities = 164/411 (39%), Positives = 245/411 (59%), Gaps = 30/411 (7%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISE-SSAPDTIELDFPDISF 59
M PF+ SAPGKVI+FGEH+ V+ KPA+AA++S LR+YLL++ S + TI L FPDI+
Sbjct: 50 MMPPFMVSAPGKVIVFGEHAVVHGKPAIAAAIS-LRSYLLVTSLSKSKRTISLRFPDINL 108
Query: 60 NHKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLS-------ESFHY 112
+H W+I+D T + +K L ELV+ + P L +S H
Sbjct: 109 SHTWNIDDLPWSTFSHPSKKKHY--YDEVTSLDPELVAAMKPHLENISPDESPAIRKIHQ 166
Query: 113 HAAFCFLYMFVCLCPHA-KNIKFSLKSTLPIGAGLGSSASISVSLALA-MAYLGGLIGSN 170
+A FLY+F+ L + ++L+ST+PIGAGLGSSASISV L+ A + + L G +
Sbjct: 167 SSASSFLYIFLSLGSQSFPGCLYTLRSTIPIGAGLGSSASISVCLSSALLLQIRTLSGPH 226
Query: 171 DLEKLSENDKHI--VNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNF 228
+ +E + +N+WAF+GE CIHG PSG+DN V+T G A++++K T+
Sbjct: 227 PDQPSNEASLQLERINRWAFVGEMCIHGNPSGVDNTVSTQGKAVIYQKSPDGPTV----- 281
Query: 229 KFLDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMT 288
K L +FP +P++L T+ +ST VA+V L+ +K P ++ IL+A+ ++
Sbjct: 282 KPLRNFPELPLLLVDTQQAKSTAHEVAKV-DLLKQKHPAIVDSILNAID--------MVG 332
Query: 289 KLSKCKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTK 348
+ + +D E + + E L +L+ +NHGLLVS+GVSHP LE I+ L D IG TK
Sbjct: 333 QSAAVMISDPEYDSEDLKCVEDLGKLMTVNHGLLVSLGVSHPRLERIRELVDHEGIGWTK 392
Query: 349 LTGAGGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLL 399
LTGAGGGGCS+TLL+ T +++ ++ L+ + Y+ FET LG G +L
Sbjct: 393 LTGAGGGGCSITLLKPGTTHDRMTRLEETLETE-GYKKFETTLGCDGVGVL 442
>ref|XP_001382664.2| mevalonate kinase [Pichia stipitis CBS 6054]
gb|ABN64635.2| mevalonate kinase [Pichia stipitis CBS 6054]
Length = 432
Score = 419 bits (1078), Expect = e-115, Method: Composition-based stats.
Identities = 187/422 (44%), Positives = 260/422 (61%), Gaps = 26/422 (6%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFN 60
MS PF SAPGKVIIFGEHSAVY KPA+AA++S LR YLL++ S PDTI L FPDI+
Sbjct: 1 MSTPFFVSAPGKVIIFGEHSAVYGKPAIAAALS-LRAYLLVTPSQDPDTINLSFPDINLT 59
Query: 61 HKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLY 120
H W+ ND + + + + Q ++ L E+V L +LA L+ S HY A CFLY
Sbjct: 60 HSWNKNDIPWDSIVK-HINLVDNLPQTSEELVPEIVDQLGSVLADLNSSLHYTACLCFLY 118
Query: 121 MFVCLCPH-AKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLIGS------NDLE 173
++ LC + F ++STLPIGAGLGSSAS +V LA A+A LG + S + +
Sbjct: 119 LYTHLCNQELAGMSFCIRSTLPIGAGLGSSASTAVCLASALAILGNRVTSASFLQTDKIL 178
Query: 174 KLSENDKHIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLDD 233
K ND ++ W+ +GEKC HG PSGIDNAVAT+G A++F++ N + + +
Sbjct: 179 KKENNDLDFIDSWSLMGEKCFHGNPSGIDNAVATHGGAVMFQR--MNNPAQPSVRTSMRN 236
Query: 234 FPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSKC 293
FPAI ++LT T++PRST DLV V L E +P+ IL+AM + +IM +
Sbjct: 237 FPAIKLLLTNTKVPRSTADLVGGVGKLNVE-YPKTSNSILEAMEHLSNTAYQIMVRP--- 292
Query: 294 KGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGAG 353
E ++L EL+ INHGLLV++GVSHP LE +K ++D ++GSTKLTGAG
Sbjct: 293 --------FFGAEERKKLRELVNINHGLLVALGVSHPSLEKVKIITDTSKLGSTKLTGAG 344
Query: 354 GGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLNKDLKIKSL 413
GGGC++TL+ D+++ I +L+ + YE FET LGG G LS +++ ++L +S
Sbjct: 345 GGGCAITLVDEDVSEADIAQGIAELEKE-GYECFETSLGGKGVGSLSFEDVPQEL--RST 401
Query: 414 VF 415
VF
Sbjct: 402 VF 403
>ref|XP_001214601.1| conserved hypothetical protein [Aspergillus terreus NIH2624]
gb|EAU34492.1| conserved hypothetical protein [Aspergillus terreus NIH2624]
Length = 541
Score = 419 bits (1077), Expect = e-115, Method: Composition-based stats.
Identities = 162/411 (39%), Positives = 233/411 (56%), Gaps = 28/411 (6%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISE-SSAPDTIELDFPDISF 59
++ F+ SAPGKVI+FGEH+ V+ K A+AA++S LR+YLL++ + + T+ L+F DI
Sbjct: 92 LAPTFMVSAPGKVIVFGEHAVVHGKAAMAAAIS-LRSYLLVTTLTKSQRTVTLNFRDIGL 150
Query: 60 NHKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLS-------ESFHY 112
H W+I+D Q +K L ELV + P + Q+S H
Sbjct: 151 AHTWNIDDLPWDVFHQPAKKKYY--YDLVTSLDPELVDAIQPYVDQVSPDLPEDQRKIHR 208
Query: 113 HAAFCFLYMFVCL-CPHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMA-YLGGLIGSN 170
+A FLY+ + L P ++L+ST+PIGAGLGSSAS+ V L+ A+ + L G +
Sbjct: 209 RSASAFLYLLLSLGSPQHPGAIYTLRSTIPIGAGLGSSASVCVCLSAALLLQIRTLAGPH 268
Query: 171 DLEKLSENDKHI--VNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNF 228
+ E + I +N+WAF+GE C HG PSG+DN V+ G A++F + ++ +
Sbjct: 269 PDQPPDEAEVQIERINRWAFVGEMCTHGNPSGVDNTVSAGGKAVIFRRTDYS---KPPSV 325
Query: 229 KFLDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMT 288
+ L FP +P++L TR PRST VA+V L E+ P V + ILDA+ + L E++
Sbjct: 326 RSLPTFPELPLLLVDTRQPRSTAVEVAKVGKL-KEEHPVVTESILDAIDKLTLSAEELLD 384
Query: 289 KLSKCKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTK 348
K T E+ E+L L+RINHG LVS+GVSHP LE I+ L D IG TK
Sbjct: 385 GCEKTGVT--------EEVLERLGTLVRINHGFLVSLGVSHPRLERIRELVDFANIGWTK 436
Query: 349 LTGAGGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLL 399
LTGAGGGGC++TLLR D + + + KL + +ET LGG G +L
Sbjct: 437 LTGAGGGGCAITLLRPDADKNAVRDLEAKL-AAEGFAKYETTLGGDGIGVL 486
>ref|XP_001267243.1| mevalonate kinase [Neosartorya fischeri NRRL 181]
gb|EAW25346.1| mevalonate kinase [Neosartorya fischeri NRRL 181]
Length = 538
Score = 418 bits (1076), Expect = e-115, Method: Composition-based stats.
Identities = 157/411 (38%), Positives = 232/411 (56%), Gaps = 28/411 (6%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISE-SSAPDTIELDFPDISF 59
M+ F+ SAPGKVI++GEH+ V+ K A+AA++S LR+YLL++ S + TI ++F DI
Sbjct: 88 MAPAFMVSAPGKVIVYGEHAVVHGKAAMAAAIS-LRSYLLVTTLSKSQRTITMNFRDIGL 146
Query: 60 NHKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLS-------ESFHY 112
+H W+I++ + +K L ELV+ + P +S H
Sbjct: 147 DHTWNIDELPWDVFHHPSKKKFY--YDLVTSLDPELVAAIQPHADAVSPEKPEDVRKIHR 204
Query: 113 HAAFCFLYMFVCL-CPHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMA-YLGGLIGSN 170
+A FLY+F+ L ++L+ST+PIGAGLGSSAS+ V L+ A+ + L G +
Sbjct: 205 RSASAFLYLFLSLGSSQNPGAIYTLRSTIPIGAGLGSSASVCVCLSAALLLQIRTLAGPH 264
Query: 171 DLEKLSENDKHI--VNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNF 228
+ E + I +N+WAF+GE C HG PSG+DN V+ G A++F ++ ++
Sbjct: 265 PDQPPDEAEVQIERINRWAFVGEMCTHGNPSGVDNTVSAGGKAVVFRREDYSKPPTVT-- 322
Query: 229 KFLDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMT 288
L +FP +P++L TR RST VA+V L E P V IL+A+ + L + +
Sbjct: 323 -PLLNFPELPLLLVDTRQSRSTAVEVAKVGKLKDE-HPVVADSILEAIDQVTLAAQQKIQ 380
Query: 289 KLSKCKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTK 348
++S ++ E L LIRINHG LVS+GVSHP LE I+ L D IG TK
Sbjct: 381 EISTNGISER--------TLEDLGTLIRINHGFLVSLGVSHPRLERIRELVDYADIGWTK 432
Query: 349 LTGAGGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLL 399
LTGAGGGGC++TLLR D +E + ++KL + + +ET LGG G +L
Sbjct: 433 LTGAGGGGCAITLLRPDTKEEAVRELEEKL-NAEGFVKYETTLGGDGIGVL 482
>gb|EDP50156.1| mevalonate kinase [Aspergillus fumigatus A1163]
Length = 538
Score = 418 bits (1075), Expect = e-115, Method: Composition-based stats.
Identities = 158/411 (38%), Positives = 233/411 (56%), Gaps = 28/411 (6%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISE-SSAPDTIELDFPDISF 59
M+ F+ SAPGKVI++GEH+ V+ K A+AA++S LR+YLL++ S + TI ++F DI
Sbjct: 88 MAPAFMVSAPGKVIVYGEHAVVHGKAAMAAAIS-LRSYLLVTTLSKSQRTITMNFRDIGL 146
Query: 60 NHKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLS-------ESFHY 112
+H W+I++ + +K L ELV+ + P +S H
Sbjct: 147 DHTWNIDELPWDVFHHPSKKKFY--YDLVTSLDPELVAAIQPHADAVSPDKPEDVRKIHR 204
Query: 113 HAAFCFLYMFVCL-CPHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMA-YLGGLIGSN 170
+A FLY+F+ L ++L+ST+PIGAGLGSSAS+ V L+ A+ + L G +
Sbjct: 205 RSASAFLYLFLSLGSSQNPGAIYTLRSTIPIGAGLGSSASVCVCLSAALLLQIRTLAGPH 264
Query: 171 DLEKLSENDKHI--VNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNF 228
+ E + I +N+WAF+GE C HG PSG+DN V+ G A++F ++ ++
Sbjct: 265 PDQPPDEAEVQIERINRWAFVGEMCTHGNPSGVDNTVSAGGKAVVFRREDYSKPPTVT-- 322
Query: 229 KFLDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMT 288
L +FP +P++L TR RST VA+V L E +P V IL+A+ + L + +
Sbjct: 323 -PLLNFPELPLLLVDTRQSRSTAVEVAKVGKLKDE-YPVVTDSILEAIDQVTLAAQQKIQ 380
Query: 289 KLSKCKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTK 348
++S + E L LIRINHG LVS+GVSHP LE I+ L D IG TK
Sbjct: 381 EISTNG--------ISYRTLEDLGTLIRINHGFLVSLGVSHPRLERIRELVDYADIGWTK 432
Query: 349 LTGAGGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLL 399
LTGAGGGGC++TLLR DI +E + ++KL + + +ET LGG G +L
Sbjct: 433 LTGAGGGGCAITLLRPDIKEEAVRELEEKLSAE-GFVKYETTLGGDGIGVL 482
>ref|XP_752047.1| mevalonate kinase [Aspergillus fumigatus Af293]
gb|EAL90009.1| mevalonate kinase [Aspergillus fumigatus Af293]
Length = 538
Score = 418 bits (1074), Expect = e-115, Method: Composition-based stats.
Identities = 158/411 (38%), Positives = 233/411 (56%), Gaps = 28/411 (6%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISE-SSAPDTIELDFPDISF 59
M+ F+ SAPGKVI++GEH+ V+ K A+AA++S LR+YLL++ S + TI ++F DI
Sbjct: 88 MAPAFMVSAPGKVIVYGEHAVVHGKAAMAAAIS-LRSYLLVTTLSKSQRTITMNFRDIGL 146
Query: 60 NHKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLS-------ESFHY 112
+H W+I++ + +K L ELV+ + P +S H
Sbjct: 147 DHTWNIDELPWDVFHHPSKKKFY--YDLVTSLDPELVAAIQPHADAVSPDKPEDVRKIHR 204
Query: 113 HAAFCFLYMFVCL-CPHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMA-YLGGLIGSN 170
+A FLY+F+ L ++L+ST+PIGAGLGSSAS+ V L+ A+ + L G +
Sbjct: 205 RSASAFLYLFLSLGSSQNPGAIYTLRSTIPIGAGLGSSASVCVCLSAALLLQIRTLAGPH 264
Query: 171 DLEKLSENDKHI--VNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNF 228
+ E + I +N+WAF+GE C HG PSG+DN V+ G A++F ++ ++
Sbjct: 265 PDQPPDEAEVQIERINRWAFVGEMCTHGNPSGVDNTVSAGGKAVVFRREDYSKPPTVT-- 322
Query: 229 KFLDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMT 288
L +FP +P++L TR RST VA+V L E +P V IL+A+ + L + +
Sbjct: 323 -PLLNFPELPLLLVDTRQSRSTAVEVAKVGKLKDE-YPVVTDSILEAIDQVTLAAQQKIQ 380
Query: 289 KLSKCKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTK 348
++S + E L LIRINHG LVS+GVSHP LE I+ L D IG TK
Sbjct: 381 EISTNG--------ISYRTLEDLGTLIRINHGFLVSLGVSHPRLERIRELVDYADIGWTK 432
Query: 349 LTGAGGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLL 399
LTGAGGGGC++TLLR DI +E + ++KL + + +ET LGG G +L
Sbjct: 433 LTGAGGGGCAITLLRPDIKEEAVRELEEKLSAE-GFVKYETTLGGDGIGVL 482
>ref|XP_460851.1| hypothetical protein DEHA0F12188g [Debaryomyces hansenii CBS767]
emb|CAG89196.1| unnamed protein product [Debaryomyces hansenii CBS767]
Length = 433
Score = 416 bits (1070), Expect = e-114, Method: Composition-based stats.
Identities = 181/439 (41%), Positives = 255/439 (58%), Gaps = 25/439 (5%)
Query: 4 PFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFNHKW 63
PFL SAPGKVII+GEHSAVY KPA+AA++S LR YLL++ + I LDFPDI +H W
Sbjct: 5 PFLVSAPGKVIIYGEHSAVYGKPAIAAALS-LRAYLLVTPCEDVNDIRLDFPDIGLSHSW 63
Query: 64 SINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLYMFV 123
+ + + + K + T+ L E+V LL +LA + HY A CFLY++
Sbjct: 64 NKENIPWEDIRKFVTFK-DEKPVVTEELVPEIVDLLSTVLADVESKLHYTACLCFLYLYA 122
Query: 124 CLC-PHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLIGS------NDLEKLS 176
L ++F +KSTLPIGAGLGSSA +V LA A+A LG + + + K
Sbjct: 123 NLSNKDVPGMRFIVKSTLPIGAGLGSSACTAVCLASALARLGKHVSAACHTSTEKVYKKE 182
Query: 177 ENDKHIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLDDFPA 236
+D ++ W+ +GEKC HG PSGIDNAVATYG A++F++ + + +FP
Sbjct: 183 NSDLDFIDSWSLMGEKCFHGNPSGIDNAVATYGGAVMFQR--TTIPSKPSVRTTMRNFPP 240
Query: 237 IPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSKCKGT 296
I +IL T++PRST LV V V +P+ ILDAM + +IM + S K
Sbjct: 241 IKLILINTKVPRSTAALVGNVAQ-VNRTYPKCAGSILDAMEHLVFEAYQIMIRPSFGK-- 297
Query: 297 DDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGAGGGG 356
E +QL EL+ INHGLLV++GVSHP LE IK + D IGSTKLTGAGGGG
Sbjct: 298 ---------EEKDQLRELVNINHGLLVALGVSHPALEKIKIIGDTHGIGSTKLTGAGGGG 348
Query: 357 CSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLNKDLKIKSLVFQ 416
C+++L+ D+ +E I K+ +++ YETFET LGG G LS ++++KD + +
Sbjct: 349 CAISLVHDDVEEEVIQKAIKEFENE-GYETFETSLGGKGVGSLSLEDVDKDKRDTVFSAE 407
Query: 417 LFENKTTTKQQIDDLLLPG 435
+F + + +++ L
Sbjct: 408 VFSSYKD-RDEVEKALKSD 425
>ref|XP_723495.1| mevalonate kinase [Candida albicans SC5314]
ref|XP_723305.1| mevalonate kinase [Candida albicans SC5314]
gb|EAL04601.1| hypothetical protein CaO19.12272 [Candida albicans SC5314]
gb|EAL04797.1| hypothetical protein CaO19.4809 [Candida albicans SC5314]
Length = 431
Score = 416 bits (1069), Expect = e-114, Method: Composition-based stats.
Identities = 182/417 (43%), Positives = 247/417 (59%), Gaps = 24/417 (5%)
Query: 1 MS-LPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISF 59
MS LPF+ APGKVIIFGEH+AVY KPA+AA++S LR YLL+S SS +TI L FPDI
Sbjct: 1 MSQLPFIVGAPGKVIIFGEHAAVYGKPAIAAALS-LRCYLLVSPSSDSNTIRLQFPDIKL 59
Query: 60 NHKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFL 119
+H W+I D + A Q L E+V L L HY+A FCFL
Sbjct: 60 DHSWNIKDLPWEEIKPYLTYDSANKPQIPSELVPEIVDKLSSFLNGFDNKMHYYACFCFL 119
Query: 120 YMFVCLC-PHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLIGSNDLEKLSEN 178
Y+ + LC + F ++STLPIGAGLGSSAS SV L+ A+A +GG I L + +
Sbjct: 120 YLLMNLCDSKVSGMNFIVRSTLPIGAGLGSSASTSVCLSSALALMGGWINKPSLHENDKL 179
Query: 179 D------KHIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLD 232
D +++W+ IGEKC HG PSGIDNAVAT+G A++F++ S + +
Sbjct: 180 DTADIPDLEFIDKWSLIGEKCFHGNPSGIDNAVATFGGAVMFQRTSTPEQPSIRTN--MR 237
Query: 233 DFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSK 292
+FPAI ++LT T++P+ST DLVA V L E F + IL A+ + + ++M
Sbjct: 238 NFPAIKLLLTNTKVPKSTADLVAGVGRLNAE-FNSISTSILTAIEHLSQEAYKVMMNPMF 296
Query: 293 CKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGA 352
K E L +L+ INHGLLV++GVSHP LE +K + D RIG+TKLTGA
Sbjct: 297 GK-----------EETNVLRKLVNINHGLLVALGVSHPALETVKIIGDKHRIGATKLTGA 345
Query: 353 GGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLNKDLK 409
GGGGC++TL+ D+ + I + K+ +D YE+FET LGG G +L ++L+ K
Sbjct: 346 GGGGCAITLVNDDVEESVIHNAIKEFEDS-GYESFETSLGGKGVGILFHEDLDDATK 401
>ref|XP_001821298.1| hypothetical protein [Aspergillus oryzae RIB40]
dbj|BAE59296.1| unnamed protein product [Aspergillus oryzae]
Length = 534
Score = 415 bits (1068), Expect = e-114, Method: Composition-based stats.
Identities = 163/411 (39%), Positives = 234/411 (56%), Gaps = 28/411 (6%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISE-SSAPDTIELDFPDISF 59
M+ F+ SAPGKVI+FGEH+ V+ K A+AA++S LR+YLL++ + + TI L+F DI
Sbjct: 86 MAPAFMVSAPGKVIVFGEHAVVHGKAAMAAAIS-LRSYLLVTTLTKSQRTITLNFRDIGL 144
Query: 60 NHKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLS-------ESFHY 112
NH WSI++ Q +K + EL+ + PL+ ++S
Sbjct: 145 NHTWSIDELPWDLFHQPTKKKYY--YDLVTSIDPELLDAILPLVERISPDLPEDKRKHQR 202
Query: 113 HAAFCFLYMFVCL-CPHAKNIKFSLKSTLPIGAGLGSSASISVSLALA-MAYLGGLIGSN 170
AA FLY+F L P ++L+ST+P GAGLGSSASI V ++ A + + L G +
Sbjct: 203 GAATAFLYLFCALGSPQHPGAIYTLRSTIPTGAGLGSSASICVCISAALLLQIRTLAGPH 262
Query: 171 DLEKLSENDKHI--VNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNF 228
+ E + I +N+WAF+GE CIHG PSG+DN VA G A++F + ++
Sbjct: 263 PDQPPDEAEVQIERINRWAFVGEMCIHGNPSGVDNTVAAGGKAVIFRRGDYS---KPPAV 319
Query: 229 KFLDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMT 288
L +FP +P++L TR RST VA+V L E+ P V + ILD + + EI+
Sbjct: 320 SSLPNFPELPLLLVDTRQSRSTAVEVAKVGQLKEEQ-PLVTEAILDTIEKVNASAQEIIR 378
Query: 289 KLSKCKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTK 348
+ ++ + + E++ LIRINHGLLVS+GVSHP LE I+ L D IG TK
Sbjct: 379 ET--------DSSGISKDTLERIGALIRINHGLLVSLGVSHPRLERIRELVDFANIGWTK 430
Query: 349 LTGAGGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLL 399
LTGAGGGGC++TLLR D I ++KL D+ + +ET LGG G +L
Sbjct: 431 LTGAGGGGCAITLLRPDADPSAIRQLEEKL-DEEGFAKYETTLGGDGVGVL 480
>gb|EEH48028.1| mevalonate kinase [Paracoccidioides brasiliensis Pb18]
Length = 490
Score = 415 bits (1066), Expect = e-114, Method: Composition-based stats.
Identities = 160/411 (38%), Positives = 234/411 (56%), Gaps = 28/411 (6%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISE-SSAPDTIELDFPDISF 59
M+ F+ SAPGKVI+FGEH+ V+ K A+AA++S LR+YLL++ S + TI L+F DI
Sbjct: 38 MAPAFMVSAPGKVIVFGEHAVVHGKRAMAAAIS-LRSYLLVTTLSKSQRTITLNFRDIEL 96
Query: 60 NHKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLS-------ESFHY 112
+H W+I+ Q + +K + L EL+ + P +A +S H
Sbjct: 97 DHTWNIDSLPWALFCQPSKKKFY--YDSVTSLDPELLEAIQPHIADISIGKPDEVRKIHR 154
Query: 113 HAAFCFLYMFVCLC-PHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMA-YLGGLIGSN 170
+A FLY+F+ L P + ++L+ST+PIGAGLGSSASI+V L+ A+ + L G +
Sbjct: 155 SSATAFLYLFLSLSSPDSHAAIYTLRSTIPIGAGLGSSASIAVCLSAALLLQIRILAGPH 214
Query: 171 DLEKLSENDKHI--VNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNF 228
+ E + I +N+WAF+GE CIHG PSG+DN V+ G A++F + ++ +
Sbjct: 215 QDQPPEEAEVQIERINRWAFVGEMCIHGNPSGVDNTVSAGGKAVIFRRGDYS---KPPSV 271
Query: 229 KFLDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMT 288
+ DFP +P++L +R PRST VA+V P V + L A+ + T
Sbjct: 272 TPILDFPELPLLLVNSRQPRSTATEVAKVGRFCK-AHPAVAESTLAAIDQV--------T 322
Query: 289 KLSKCKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTK 348
+ + + +NE + EL RINHGLLVS+GVSHP LE I+ L D IG TK
Sbjct: 323 ESANNFIQSGRFDKDSNEDIDHFGELFRINHGLLVSLGVSHPRLERIRELVDHAGIGWTK 382
Query: 349 LTGAGGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLL 399
LTGAGGGGC++ LLR + Q + ++ L DD +E +ET LGG G +L
Sbjct: 383 LTGAGGGGCAIVLLRANTNQAVLHHLEQNL-DDEGFERYETTLGGNGIGVL 432
>ref|XP_001401587.1| hypothetical protein An04g02190 [Aspergillus niger]
emb|CAL00706.1| unnamed protein product [Aspergillus niger]
Length = 448
Score = 413 bits (1062), Expect = e-113, Method: Composition-based stats.
Identities = 156/410 (38%), Positives = 229/410 (55%), Gaps = 26/410 (6%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFN 60
M+ PF+ SAPGKVI+FGEH+ V+ K A+AA++S +L+ + S + TI L+ D+ FN
Sbjct: 1 MAPPFMVSAPGKVIVFGEHAVVHGKAAMAAAISLRSYFLVTTLSKSQRTITLNLRDMDFN 60
Query: 61 HKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLS-------ESFHYH 113
H W+I+D Q + +K L +EL L P + +S H
Sbjct: 61 HTWNIDDLPWDFFKQPSKKKYY--YDLVTSLDEELYDSLKPCVEDISPKAPEEIRKKHKG 118
Query: 114 AAFCFLYMFVCL-CPHAKNIKFSLKSTLPIGAGLGSSASISVSLALA-MAYLGGLIGSND 171
+A FLY+F L P ++L+ST+P+GAGLGSSAS+ + A + + L G +D
Sbjct: 119 SALAFLYLFCSLGSPQHPGAIYTLRSTIPMGAGLGSSASVCTCFSAALLLQIRTLAGPHD 178
Query: 172 LEKLSENDKHI--VNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFK 229
+ E + I +N+WAF+GE CIHG PSG+DN V+T G A++F ++ ++
Sbjct: 179 DQPPDEAELQIERINRWAFVGELCIHGNPSGVDNTVSTGGKAVIFRREDYS---KPPKVI 235
Query: 230 FLDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTK 289
L +FP +P++L TR RST VA+V L E P V + ILDA+ + + +
Sbjct: 236 PLPNFPELPLLLVDTRQSRSTAVEVAKVGKLKKE-HPLVTESILDAIDKVTVSAQSAIQ- 293
Query: 290 LSKCKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKL 349
E + E E + L+R+NHG LVS+GVSHP LE I+ L D IG TKL
Sbjct: 294 -------GVEGDSIDKETLEHIGTLVRVNHGFLVSLGVSHPRLERIRELVDFANIGWTKL 346
Query: 350 TGAGGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLL 399
TGAGGGGC++TLLR D + + + ++KL ++ +ET LGG G +L
Sbjct: 347 TGAGGGGCAITLLRPDASVDALRELERKL-AAENFSKYETTLGGDGIGVL 395
>ref|XP_001241830.1| hypothetical protein CIMG_05726 [Coccidioides immitis RS]
gb|EAS30247.1| hypothetical protein CIMG_05726 [Coccidioides immitis RS]
Length = 612
Score = 412 bits (1060), Expect = e-113, Method: Composition-based stats.
Identities = 150/411 (36%), Positives = 231/411 (56%), Gaps = 28/411 (6%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISE-SSAPDTIELDFPDISF 59
M+ PF+ SAPGKVI+FGEH+ V+ K A+AA++S LR+YLL++ S + T+ L+F D
Sbjct: 163 MAPPFMVSAPGKVIVFGEHAVVHGKKAMAAAIS-LRSYLLVTTLSKSRRTVTLNFRDTGL 221
Query: 60 NHKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLS-------ESFHY 112
+H W I+ + + +K L +L+ + P ++ +S H
Sbjct: 222 DHTWDIDSLPWDVFNHSSKKKFY--YDRVTSLDPDLLDAIRPHISNVSPDKPPEVRKVHQ 279
Query: 113 HAAFCFLYMFVCL-CPHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMA-YLGGLIGSN 170
+A FLY+++ L P + ++L+ST+PIGAGLGSSAS+ V L+ A+ + L G +
Sbjct: 280 GSASAFLYLYLSLGSPQSHGAIYTLRSTIPIGAGLGSSASVCVCLSAALLLQIRALAGPH 339
Query: 171 DLEKLSENDKHI--VNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNF 228
+ E++ I +N+WAF+GE CIHG PSG+DN V+ G A++F + ++
Sbjct: 340 PDQPFDESEVQIERINRWAFVGELCIHGNPSGVDNTVSAGGKAVIFRRGDYS---KPPTV 396
Query: 229 KFLDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMT 288
+ DFP +P++L +R RST VA+V L P + +LD + + + ++
Sbjct: 397 IPILDFPELPLLLVNSRQSRSTATEVAKVGTLKK-LHPAITDCLLDGIDQVTTSAHDFIS 455
Query: 289 KLSKCKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTK 348
+ + ++E L RINHGLLVS+GVSHP LE I+ L D IG TK
Sbjct: 456 --------SENFDKNSSETLNYFGTLFRINHGLLVSLGVSHPRLERIRELVDHTGIGWTK 507
Query: 349 LTGAGGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLL 399
LTGAGGGGC++TL+R D + +++L D+ YE +ET LGG G +L
Sbjct: 508 LTGAGGGGCAITLIRTDRESTALKPLERQL-DEEGYERYETTLGGQGVGVL 557
>ref|XP_370449.1| hypothetical protein MGG_06946 [Magnaporthe grisea 70-15]
gb|EDJ98120.1| hypothetical protein MGG_06946 [Magnaporthe grisea 70-15]
Length = 494
Score = 408 bits (1049), Expect = e-112, Method: Composition-based stats.
Identities = 158/399 (39%), Positives = 232/399 (58%), Gaps = 28/399 (7%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISE-SSAPDTIELDFPDISF 59
M F+ SAPGKVI+FGEHS VY K AVAA+++ LR+YLL++ S + TI L FPDI
Sbjct: 43 MMPAFMVSAPGKVIVFGEHSVVYGKKAVAAAIN-LRSYLLVTALSKSKRTITLRFPDIDL 101
Query: 60 NHKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLS-------ESFHY 112
H W+I+D T Q + +K L +L+ + P L +S H
Sbjct: 102 IHTWNIDDLPWSTFSQPSKKKYY--YDLVTSLDPDLMDAIQPHLEPVSSDAPDAQRKVHM 159
Query: 113 HAAFCFLYMFVCLCPHA-KNIKFSLKSTLPIGAGLGSSASISVSLALAMA-YLGGLIGSN 170
AA FLY+F+ L HA ++L+ST+PIGAGLGSSASIS L+ A+ + L G +
Sbjct: 160 SAAAAFLYLFMSLGSHAFPGGIYTLRSTIPIGAGLGSSASISACLSAALLLQIRTLSGPH 219
Query: 171 DLEKLSEN--DKHIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNF 228
+ E +N+WAF+ E CIHG PSG+DN V+T G A++F++ +
Sbjct: 220 PDQPPDEARVQVERINRWAFVAEMCIHGNPSGVDNTVSTQGKAVVFQRLDYARPPVVT-- 277
Query: 229 KFLDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMT 288
+ DFP +P+++ T+ +STK V +V L E P+++ ILD+M + +++T
Sbjct: 278 -PMWDFPELPLLVVDTKQAKSTKYEVEKVAKL-RETHPKIVNSILDSMDKLTQAATDVLT 335
Query: 289 KLSKCKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTK 348
D++ + E +++ EL+ +NHGLLVS+GVSHP LE ++ L D IG TK
Sbjct: 336 --------DEDFDNEDVESLQKVGELMGMNHGLLVSLGVSHPRLERVRELVDHEGIGWTK 387
Query: 349 LTGAGGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETF 387
LTGAGGGGCS+TL+R D+ +E+++ K++L D Y F
Sbjct: 388 LTGAGGGGCSITLMRPDVPREKLERLKERL-DHEGYLKF 425
>ref|XP_001527900.1| hypothetical protein LELG_00420 [Lodderomyces elongisporus NRRL
YB-4239]
gb|EDK42242.1| hypothetical protein LELG_00420 [Lodderomyces elongisporus NRRL
YB-4239]
Length = 439
Score = 406 bits (1043), Expect = e-111, Method: Composition-based stats.
Identities = 169/416 (40%), Positives = 243/416 (58%), Gaps = 24/416 (5%)
Query: 2 SLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDT-IELDFPDISFN 60
SL F+ SAPGKVIIFGEH+AVY KPA+AA++S LR +LL++ S+ + L FPDI +
Sbjct: 8 SLKFVVSAPGKVIIFGEHAAVYGKPAIAAALS-LRCFLLVTPSTGDSNMVRLKFPDIGLD 66
Query: 61 HKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLY 120
H W I+ T Q L E+V L PLL L ++ HY A FCFLY
Sbjct: 67 HSWDISSIPWETIKAKVKADSNGKPQPPAELDPEIVDSLSPLLRNLDDNVHYIACFCFLY 126
Query: 121 MFVCLCPHA-KNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLIGSNDLE------ 173
++ LC + F ++STLPIGAGLGSSAS +V L+ A++ LG I L
Sbjct: 127 LYTNLCSQDLQGYTFVVRSTLPIGAGLGSSASTAVCLSAALSKLGNWIKDPKLSNHDHVL 186
Query: 174 KLSENDKHIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLDD 233
+ + ++ W+ IGEKC HG PSGIDNAVAT+G A+ +++ + ++ + D
Sbjct: 187 ESEIPELDFIDNWSLIGEKCFHGNPSGIDNAVATHGGAVKYQR--ILNSTKSSLRSSIRD 244
Query: 234 FPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSKC 293
FP I ++LT T++P+ST LVA V L E FP++ PIL+A+ + Q E+M
Sbjct: 245 FPPIKLLLTNTKVPKSTAKLVAGVGELTKE-FPDITNPILNAVEFISEQAYEVMHLP--- 300
Query: 294 KGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGAG 353
+ + L +L+ +NHGLLV++GVSHP LE +K +SD +G+TKLTGAG
Sbjct: 301 --------QFGKQETATLRKLVNMNHGLLVALGVSHPALETVKIISDKYNLGATKLTGAG 352
Query: 354 GGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLNKDLK 409
GGGC++TL+ I + I + K+ +++ +E+FET LGG G +L + + K
Sbjct: 353 GGGCAITLVDESIDKSVIHNAMKEYENE-GFESFETSLGGKGVGMLFEDDCQESEK 407
>gb|EEH37797.1| mevalonate kinase [Paracoccidioides brasiliensis Pb01]
Length = 545
Score = 385 bits (989), Expect = e-105, Method: Composition-based stats.
Identities = 152/411 (36%), Positives = 226/411 (54%), Gaps = 44/411 (10%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISE-SSAPDTIELDFPDISF 59
M+ F+ SAPGKVI+FGEH+ V+ K A+AA++S LR+YLL++ S + TI L+F DI
Sbjct: 109 MAPAFMVSAPGKVIVFGEHAVVHGKRAMAAAIS-LRSYLLVTTLSKSQRTITLNFRDIEL 167
Query: 60 NHKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLS-------ESFHY 112
+H W I+ Q + +K + L EL+ + P +A +S + H
Sbjct: 168 DHTWDIDSLPWALFCQPSKKKFY--YDSVTSLDPELLEAIQPHIADISIGKPDEVQKIHR 225
Query: 113 HAAFCFLYMFVCLC-PHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMA-YLGGLIGSN 170
+A FLY+F+ L P + ++L+ST+PIGAGLGSSASI+V L+ A+ + L G +
Sbjct: 226 SSATAFLYLFLSLSSPGSHAAIYTLRSTIPIGAGLGSSASIAVCLSAALLLQIRILAGPH 285
Query: 171 DLEKLSENDKHI--VNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNF 228
+ E + I +N+WAF+GE CIHG PSG+DN V+ G A++F + ++ +
Sbjct: 286 HDQPPEEAEVQIERINRWAFVGEMCIHGNPSGVDNTVSAGGKAVIFRRGDYS---KPPSV 342
Query: 229 KFLDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMT 288
+ DFP +P++L + P A+ E L ++ +T
Sbjct: 343 TPILDFPELPLLLAGSAKPTP-------------------------AVAESTLAAIDQVT 377
Query: 289 KLSKCKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTK 348
+ + + +NE + EL RINHGLLVS+GVSHP LE I+ L D IG TK
Sbjct: 378 ESANNFIQSGRFDKDSNEDIDHFGELFRINHGLLVSLGVSHPRLERIRELVDHAGIGWTK 437
Query: 349 LTGAGGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLL 399
LTGAGGGGC++ LLR + Q + ++ L DD +E +ET LGG G +L
Sbjct: 438 LTGAGGGGCAIVLLRANTNQAVLHHLEQNL-DDEGFERYETTLGGDGIGVL 487
>ref|XP_001483309.1| hypothetical protein PGUG_04038 [Pichia guilliermondii ATCC 6260]
gb|EDK39940.1| hypothetical protein PGUG_04038 [Pichia guilliermondii ATCC 6260]
Length = 423
Score = 372 bits (956), Expect = e-101, Method: Composition-based stats.
Identities = 163/433 (37%), Positives = 243/433 (56%), Gaps = 26/433 (6%)
Query: 4 PFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFNHKW 63
PF SAPGKVI+FGEH+AVY KP A + + L++ + D++ L+FPDI +H W
Sbjct: 3 PFYISAPGKVILFGEHAAVYGKP--ALAAALSLRAYLLATETNDDSLRLEFPDIQLSHSW 60
Query: 64 SINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLYMFV 123
+++ Q + ++ TD L+ E+++L+ L + + HY CFLY+++
Sbjct: 61 KLSELPWENA-QAHIERKNGKPVPTDELNPEVINLIGEFLGDIESTAHYTTCLCFLYLYL 119
Query: 124 CLC-PHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLIGSNDLEK-----LSE 177
LC P + F ++STLPIGAGLGSSAS +V L +A LGG I S +
Sbjct: 120 HLCDPLVASRSFCIRSTLPIGAGLGSSASAAVCLTSTLALLGGHIRSPQYSEKQRVSSEN 179
Query: 178 NDKHIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLDDFPAI 237
D ++ W+ +GEKC HG PSGIDNAVAT+G A+++++ + + +FP +
Sbjct: 180 PDAEFIDSWSLMGEKCFHGNPSGIDNAVATHGGAVMYQRMLAPDMPSVRT--AMRNFPPL 237
Query: 238 PMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSKCKGTD 297
++LT T++PRST +LV V V + P+ ILDA+ A IM+ S
Sbjct: 238 KLLLTNTKVPRSTAELVGGVAK-VNTRHPKTAGSILDAVSHLATDAYHIMSHPSFAA--- 293
Query: 298 DEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGAGGGGC 357
E E L +L+ INHGLLV++GVSHP LE IK + D RIG+TKLTGAGGGGC
Sbjct: 294 --------EDRESLRQLVNINHGLLVALGVSHPALEKIKMIGDTNRIGATKLTGAGGGGC 345
Query: 358 SLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLNKDLKIKSL-VFQ 416
++TLL +++ E ++ + + + +ETFE LGG G L N + D ++ S+ F
Sbjct: 346 AITLLNDEVSHEVLEKVENEFTQE-GFETFEATLGGKGVGALFCDN-DSDPEVFSVERFV 403
Query: 417 LFENKTTTKQQID 429
F + K ++
Sbjct: 404 NFSRREDIKNALE 416
>emb|CAA53059.1| unnamed protein product [Hepatitis B virus]
Length = 557
Score = 371 bits (952), Expect = e-101, Method: Composition-based stats.
Identities = 132/417 (31%), Positives = 222/417 (53%), Gaps = 36/417 (8%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFN 60
+S L SAPGKVI+ GEH+ V+ K A+A S++ LRT+L + S ++L P+I
Sbjct: 163 LSEVLLVSAPGKVILHGEHAVVHGKVALAVSLN-LRTFLRLQPHSN-GKVDLSLPNIGIK 220
Query: 61 HKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLY 120
W + ++ + + +E+ L D ++E A FLY
Sbjct: 221 RAWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDD--CAVTE---RLAVLAFLY 275
Query: 121 MFVCLCPH---AKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLI-----GSNDL 172
+++ +C ++ + S LP GAGLGSSA+ SV LA A+ + I + +
Sbjct: 276 LYLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCV 335
Query: 173 EKLSENDKHIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLD 232
+ ++ D ++N+WAF GE+ IHG PSG+DNAV+T+G AL + H G I++ L
Sbjct: 336 NRWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRY----HQGKISS-----LK 386
Query: 233 DFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSK 292
PA+ ++LT T++PR+T+ LVA VR + KFPE++ P+L ++ +L+ ++ ++ +
Sbjct: 387 RSPALQILLTNTKVPRNTRALVAGVRNRLL-KFPEIVAPLLTSIDAISLECERVLGEMGE 445
Query: 293 CKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGA 352
E Y L ELI +N L ++GV H L+ + ++ +KLTGA
Sbjct: 446 APA---------PEQYLVLEELIDMNQHHLNALGVGHASLDQLCQVTRARG-LHSKLTGA 495
Query: 353 GGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLNKDLK 409
GGGGC +TLL+ + Q ++++ K+ L ++ ET +G G + SA +L+ ++
Sbjct: 496 GGGGCGITLLKPGLEQPEVEATKQALT-SCGFDCLETSIGAPGVSIHSATSLDSRVQ 551
>ref|XP_001105759.1| PREDICTED: mevalonate kinase isoform 2 [Macaca mulatta]
ref|XP_001105815.1| PREDICTED: mevalonate kinase isoform 3 [Macaca mulatta]
Length = 396
Score = 367 bits (942), Expect = 1e-99, Method: Composition-based stats.
Identities = 131/418 (31%), Positives = 222/418 (53%), Gaps = 38/418 (9%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFN 60
+S L SAPGKVI+ GEH+ V+ K A+A +++ LRT+L + S ++L P+I
Sbjct: 2 LSEVLLVSAPGKVILHGEHAVVHGKVALAVALN-LRTFLRLQPHSN-GKVDLSLPNIGIK 59
Query: 61 HKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLD-PLLAQLSESFHYHAAFCFL 119
W + + + A T L ++L + P ++ES A FL
Sbjct: 60 WAWDVARLQLLDTSFLEQG---DATTPTPELVEKLKEVAGLPDDCAVTESL---AVLAFL 113
Query: 120 YMFVCLCPH---AKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLI-----GSND 171
Y+++ +C ++ + S LP GAGLGSSA+ SV LA A+ + I +
Sbjct: 114 YLYLSICRKQRALPSLDIVVWSELPHGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDR 173
Query: 172 LEKLSENDKHIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFL 231
+ + ++ D ++N+WAF GE+ IHG PSG+DNAV+T+G AL +++ L
Sbjct: 174 VNRWTKEDLELINKWAFQGERVIHGNPSGVDNAVSTWGGALRYQQG---------KISSL 224
Query: 232 DDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLS 291
PA+ ++LT T++PR+T+ LVA VR + KFPE++ P+L ++ +L+ ++ ++
Sbjct: 225 KRPPALQILLTNTKVPRNTRTLVAGVRNRLL-KFPEIVAPLLTSIDAISLECERVLGEMG 283
Query: 292 KCKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTG 351
+ E Y L ELI +N L ++GV H L+ + ++ +KLTG
Sbjct: 284 EAPA---------PEQYLVLEELIDMNQHHLNALGVGHASLDQLCQVTRAHG-LHSKLTG 333
Query: 352 AGGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLNKDLK 409
AGGGGC +TLL+ + Q ++++ K+ L ++ +ET +G G + SA +L+ ++
Sbjct: 334 AGGGGCGITLLKPGLEQPEVEATKQALT-SCGFDCWETSIGAPGVSIHSATSLDSRVQ 390
>dbj|BAD92959.1| mevalonate kinase variant [Homo sapiens]
Length = 421
Score = 361 bits (927), Expect = 6e-98, Method: Composition-based stats.
Identities = 132/417 (31%), Positives = 223/417 (53%), Gaps = 36/417 (8%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFN 60
+S L SAPGKVI+ GEH+ V+ K A+A S++ LRT+L + S ++L+ P+I
Sbjct: 27 LSEVLLVSAPGKVILHGEHAVVHGKVALAVSLN-LRTFLRLQPHSN-GKVDLNLPNIGIK 84
Query: 61 HKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLY 120
W + ++ + + +E+ L D ++E A FLY
Sbjct: 85 RAWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDD--CAVTE---RLAVLAFLY 139
Query: 121 MFVCLCPH---AKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLI-----GSNDL 172
+++ +C ++ + S LP GAGLGSSA+ SV LA A+ + I + +
Sbjct: 140 LYLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCV 199
Query: 173 EKLSENDKHIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLD 232
+ ++ D ++N+WAF GE+ IHG PSG+DNAV+T+G AL + H G I++ L
Sbjct: 200 NRWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRY----HQGKISS-----LK 250
Query: 233 DFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSK 292
PA+ ++LT T++PR+T+ LVA VR + KFPE++ P+L ++ +L+ ++ ++ +
Sbjct: 251 RSPALQILLTNTKVPRNTRALVAGVRNRLL-KFPEIVAPLLTSIDAISLECERVLGEMGE 309
Query: 293 CKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGA 352
E Y L ELI +N L ++GV H L+ + ++ +KLTGA
Sbjct: 310 APA---------PEQYLVLEELIDMNQHHLNALGVGHASLDQLCQVTRARG-LHSKLTGA 359
Query: 353 GGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLNKDLK 409
GGGGC +TLL+ + Q ++++ K+ L ++ ET +G G + SA +L+ ++
Sbjct: 360 GGGGCGITLLKPGLEQPEVEATKQALT-SCGFDCLETSIGAPGVSIHSATSLDSRVQ 415
>ref|NP_000422.1| mevalonate kinase [Homo sapiens]
ref|NP_001107657.1| mevalonate kinase [Homo sapiens]
sp|Q03426|KIME_HUMAN Mevalonate kinase (MK)
gb|AAB59362.1| mevalonate kinase
emb|CAA53060.1| unnamed protein product [Homo sapiens]
gb|AAF82407.1| mevalonate kinase [Homo sapiens]
gb|AAH16140.1| MVK protein [Homo sapiens]
gb|EAW97872.1| mevalonate kinase (mevalonic aciduria), isoform CRA_c [Homo
sapiens]
gb|EAW97873.1| mevalonate kinase (mevalonic aciduria), isoform CRA_c [Homo
sapiens]
gb|ABM82015.1| mevalonate kinase (mevalonic aciduria) [synthetic construct]
gb|ABM85197.1| mevalonate kinase (mevalonic aciduria) [synthetic construct]
Length = 396
Score = 360 bits (923), Expect = 2e-97, Method: Composition-based stats.
Identities = 132/417 (31%), Positives = 222/417 (53%), Gaps = 36/417 (8%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFN 60
+S L SAPGKVI+ GEH+ V+ K A+A S++ LRT+L + S ++L P+I
Sbjct: 2 LSEVLLVSAPGKVILHGEHAVVHGKVALAVSLN-LRTFLRLQPHSN-GKVDLSLPNIGIK 59
Query: 61 HKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLY 120
W + ++ + + +E+ L D ++E A FLY
Sbjct: 60 RAWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDD--CAVTE---RLAVLAFLY 114
Query: 121 MFVCLCPH---AKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLI-----GSNDL 172
+++ +C ++ + S LP GAGLGSSA+ SV LA A+ + I + +
Sbjct: 115 LYLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCV 174
Query: 173 EKLSENDKHIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLD 232
+ ++ D ++N+WAF GE+ IHG PSG+DNAV+T+G AL + H G I++ L
Sbjct: 175 NRWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRY----HQGKISS-----LK 225
Query: 233 DFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSK 292
PA+ ++LT T++PR+T+ LVA VR + KFPE++ P+L ++ +L+ ++ ++ +
Sbjct: 226 RSPALQILLTNTKVPRNTRALVAGVRNRLL-KFPEIVAPLLTSIDAISLECERVLGEMGE 284
Query: 293 CKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGA 352
E Y L ELI +N L ++GV H L+ + ++ +KLTGA
Sbjct: 285 APA---------PEQYLVLEELIDMNQHHLNALGVGHASLDQLCQVTRARG-LHSKLTGA 334
Query: 353 GGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLNKDLK 409
GGGGC +TLL+ + Q ++++ K+ L ++ ET +G G + SA +L+ ++
Sbjct: 335 GGGGCGITLLKPGLEQPEVEATKQALT-SCGFDCLETSIGAPGVSIHSATSLDSRVQ 390
>gb|AAQ02416.1| mevalonate kinase [synthetic construct]
Length = 397
Score = 360 bits (923), Expect = 2e-97, Method: Composition-based stats.
Identities = 132/417 (31%), Positives = 222/417 (53%), Gaps = 36/417 (8%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFN 60
+S L SAPGKVI+ GEH+ V+ K A+A S++ LRT+L + S ++L P+I
Sbjct: 2 LSEVLLVSAPGKVILHGEHAVVHGKVALAVSLN-LRTFLRLQPHSN-GKVDLSLPNIGIK 59
Query: 61 HKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLY 120
W + ++ + + +E+ L D ++E A FLY
Sbjct: 60 RAWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDD--CAVTE---RLAVLAFLY 114
Query: 121 MFVCLCPH---AKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLI-----GSNDL 172
+++ +C ++ + S LP GAGLGSSA+ SV LA A+ + I + +
Sbjct: 115 LYLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCV 174
Query: 173 EKLSENDKHIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLD 232
+ ++ D ++N+WAF GE+ IHG PSG+DNAV+T+G AL + H G I++ L
Sbjct: 175 NRWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRY----HQGKISS-----LK 225
Query: 233 DFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSK 292
PA+ ++LT T++PR+T+ LVA VR + KFPE++ P+L ++ +L+ ++ ++ +
Sbjct: 226 RSPALQILLTNTKVPRNTRALVAGVRNRLL-KFPEIVAPLLTSIDAISLECERVLGEMGE 284
Query: 293 CKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGA 352
E Y L ELI +N L ++GV H L+ + ++ +KLTGA
Sbjct: 285 APA---------PEQYLVLEELIDMNQHHLNALGVGHASLDQLCQVTRARG-LHSKLTGA 334
Query: 353 GGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLNKDLK 409
GGGGC +TLL+ + Q ++++ K+ L ++ ET +G G + SA +L+ ++
Sbjct: 335 GGGGCGITLLKPGLEQPEVEATKQALT-SCGFDCLETSIGAPGVSIHSATSLDSRVQ 390
>dbj|BAA24409.1| mevalonate kinase [Saccharomyces cerevisiae]
Length = 246
Score = 358 bits (919), Expect = 6e-97, Method: Composition-based stats.
Identities = 246/246 (100%), Positives = 246/246 (100%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFN 60
MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFN
Sbjct: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFN 60
Query: 61 HKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLY 120
HKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLY
Sbjct: 61 HKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLY 120
Query: 121 MFVCLCPHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLIGSNDLEKLSENDK 180
MFVCLCPHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLIGSNDLEKLSENDK
Sbjct: 121 MFVCLCPHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLIGSNDLEKLSENDK 180
Query: 181 HIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLDDFPAIPMI 240
HIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLDDFPAIPMI
Sbjct: 181 HIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLDDFPAIPMI 240
Query: 241 LTYTRI 246
LTYTRI
Sbjct: 241 LTYTRI 246
>gb|AAX08684.1| mevalonate kinase [Bos taurus]
Length = 396
Score = 357 bits (916), Expect = 1e-96, Method: Composition-based stats.
Identities = 126/417 (30%), Positives = 212/417 (50%), Gaps = 36/417 (8%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFN 60
+S L SAPGKVI+ GEH+ V+ K A+A +++ LRT+L + S + L+ P+I
Sbjct: 2 LSEVLLVSAPGKVILHGEHAVVHGKVALAVALN-LRTFLRLQPHSN-GRVGLNLPNIGVR 59
Query: 61 HKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLY 120
W + + + A +E+ + + A FLY
Sbjct: 60 RAWDVASLQLLDTSFLGHGDSAALTAKHVEKLKEVAGFPKDCVDP-----EHLAVLAFLY 114
Query: 121 MFVCLCPH---AKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLI-----GSNDL 172
+++ +C ++ ++ S LP GAGLGSSA+ SV LA A+ I
Sbjct: 115 LYLSICQSQRVLPSLDITVWSELPTGAGLGSSAAYSVCLAAALLTACEEIPNPLKDGEAA 174
Query: 173 EKLSENDKHIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLD 232
+ +E + ++N+WAF GE+ IHG PSG+DNAV+T+G AL +++ L
Sbjct: 175 GRWTEENLELINKWAFQGERVIHGNPSGVDNAVSTWGGALRYQQG---------KISSLK 225
Query: 233 DFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSK 292
P + ++L T++PRSTK LVA VR + KFPE++ P+L ++ +L+ ++ +++
Sbjct: 226 RPPVLKILLINTKVPRSTKVLVANVRSRLL-KFPEIVAPLLTSIDAISLECERVLGEMAA 284
Query: 293 CKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGA 352
E Y L ELI +N L ++GV H L+ + ++ +KLTGA
Sbjct: 285 AP---------TPEHYLTLEELIDMNQHHLNALGVGHASLDQLCQVTTAHG-LHSKLTGA 334
Query: 353 GGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLNKDLK 409
GGGGC +TLLR D+ + +++ K+ L ++ +ET +G G + +A +L+ ++
Sbjct: 335 GGGGCGITLLRPDVERPAVEATKRALSG-CGFDCWETSVGAPGVSVHTAASLDASVQ 390
>ref|XP_543435.2| PREDICTED: similar to Mevalonate kinase (MK) [Canis familiaris]
Length = 409
Score = 357 bits (916), Expect = 1e-96, Method: Composition-based stats.
Identities = 130/419 (31%), Positives = 212/419 (50%), Gaps = 36/419 (8%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFN 60
+S L SAPGKVI+ GEH+ V+ K A+A +++ LRT+L + S + L+ P+I
Sbjct: 11 LSEVLLVSAPGKVILHGEHAVVHGKIALAVALN-LRTFLRLQPHSN-GKMCLNLPNIGVK 68
Query: 61 HKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHY--HAAFCF 118
W + + A E V L + + A F
Sbjct: 69 RAWDVARLQLQDTSFLEPGNATGDAAAPTS---EQVEKLKEVAGIPKDGADPECLAVLAF 125
Query: 119 LYMFVCLCPH---AKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLIGS-----N 170
LY+++ +C ++ ++ S LP GAGLGSSA+ SV LA A+ I +
Sbjct: 126 LYLYLSICRKQRTLPSLDITVWSELPTGAGLGSSAAYSVCLAAALLTACEAIPNPQNNGE 185
Query: 171 DLEKLSENDKHIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKF 230
+ + D ++N+WAF GE+ IHG PSG+DN ++T+G AL +++
Sbjct: 186 SASRWTMEDLELINKWAFQGERMIHGNPSGVDNTISTWGGALRYQQG---------KISS 236
Query: 231 LDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKL 290
+ PA+ ++LT T++PRSTK LVA VR + KFPE++ P+L ++ +L+ + ++
Sbjct: 237 IKRLPALKILLTNTKVPRSTKALVASVRSRLL-KFPEIVAPLLTSINAISLECERTLEEM 295
Query: 291 SKCKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLT 350
+ E Y L ELI IN L ++GV H L+ + ++ +KLT
Sbjct: 296 ASAPA---------PEHYLVLEELIDINQHHLNALGVGHASLDQLCQVTMAHG-LHSKLT 345
Query: 351 GAGGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLNKDLK 409
GAGGGGC +TLLR D+ Q ++++ K+ L ++ +ET +G G + SA +L+ ++
Sbjct: 346 GAGGGGCGITLLRPDLEQPKVEAMKQALT-SCGFDCWETRIGAPGISIHSAASLDTQVQ 403
>ref|NP_001015528.1| mevalonate kinase [Bos taurus]
sp|Q5E9T8|KIME_BOVIN Mevalonate kinase (MK)
gb|AAX08849.1| mevalonate kinase [Bos taurus]
gb|AAI04541.1| Mevalonate kinase (mevalonic aciduria) [Bos taurus]
Length = 396
Score = 356 bits (915), Expect = 1e-96, Method: Composition-based stats.
Identities = 126/417 (30%), Positives = 212/417 (50%), Gaps = 36/417 (8%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFN 60
+S L SAPGKVI+ GEH+ V+ K A+A +++ LRT+L + S + L+ P+I
Sbjct: 2 LSEVLLVSAPGKVILHGEHAVVHGKVALAVALN-LRTFLRLQPHSN-GRVGLNLPNIGVR 59
Query: 61 HKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLY 120
W + + + A +E+ + + A FLY
Sbjct: 60 RAWDVASLQLLDTSFLGHGDSAALTAKHVEKLKEVAGFPKDCVDP-----EHLAVLAFLY 114
Query: 121 MFVCLCPH---AKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLI-----GSNDL 172
+++ +C ++ ++ S LP GAGLGSSA+ SV LA A+ I
Sbjct: 115 LYLSICQSQRALPSLDITVWSELPTGAGLGSSAAYSVCLAAALLTACEEIPNPLKDGEAA 174
Query: 173 EKLSENDKHIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLD 232
+ +E + ++N+WAF GE+ IHG PSG+DNAV+T+G AL +++ L
Sbjct: 175 GRWTEENLELINKWAFQGERVIHGNPSGVDNAVSTWGGALRYQQG---------KISSLK 225
Query: 233 DFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSK 292
P + ++L T++PRSTK LVA VR + KFPE++ P+L ++ +L+ ++ +++
Sbjct: 226 RPPVLKILLINTKVPRSTKVLVANVRSRLL-KFPEIVAPLLTSIDAISLECERVLGEMAA 284
Query: 293 CKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGA 352
E Y L ELI +N L ++GV H L+ + ++ +KLTGA
Sbjct: 285 AP---------TPEHYLTLEELIDMNQHHLNALGVGHASLDQLCQVTTAHG-LHSKLTGA 334
Query: 353 GGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLNKDLK 409
GGGGC +TLLR D+ + +++ K+ L ++ +ET +G G + +A +L+ ++
Sbjct: 335 GGGGCGITLLRPDVERPAVEATKRALSG-CGFDCWETSVGAPGVSVHTAASLDASVQ 390
>ref|XP_790690.1| PREDICTED: similar to Mevalonate kinase (MK) [Strongylocentrotus
purpuratus]
ref|XP_001200159.1| PREDICTED: similar to Mevalonate kinase (MK) [Strongylocentrotus
purpuratus]
Length = 413
Score = 352 bits (904), Expect = 3e-95, Method: Composition-based stats.
Identities = 130/407 (31%), Positives = 200/407 (49%), Gaps = 34/407 (8%)
Query: 4 PFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFNHKW 63
SAPGK+I+ GEH+ V+ K A+AA ++ LR+YL + E + L+ PDI W
Sbjct: 15 SIFISAPGKIILHGEHAVVHGKTALAAGLN-LRSYLCLKE-KDSGRLHLNLPDIDLERSW 72
Query: 64 SINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQ-LSESFHYHAAFCFLYMF 122
+ + D +NS + E++ L L +E+ A FLY++
Sbjct: 73 DVLELQEQFRDLLNSDVMEVKPSV------EIMQRLRLFLGYSDTETTKRLAVMAFLYLY 126
Query: 123 VCLCPHAKNIKFS---LKSTLPIGAGLGSSASISVSLALAMAYLGGLIGSNDLEK----L 175
+C+ + S LP GAGLGSSA+ SV LA + I L
Sbjct: 127 LCIAGRNGKFPILDTLVSSALPPGAGLGSSAAFSVCLAAGLLTWAKAIIPLSLSDNTLDW 186
Query: 176 SENDKHIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLDDFP 235
S D ++N WA+ GE+ IHG PSGIDN+++ +G A+ + + L++ P
Sbjct: 187 SREDMELINTWAYEGERVIHGNPSGIDNSISVHGGAIEYRQK---------VITPLENMP 237
Query: 236 AIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSKCKG 295
+ ++L T + RSTK+LVA V +K+P+V PILD++ E + + + L +
Sbjct: 238 ELSILLVNTCVARSTKELVAGV-QRRHDKYPKVYGPILDSIEEISQECKRTLQALKTGES 296
Query: 296 TDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGAGGG 355
D + ++ L EL+ IN LL IGVSHP + I + +I KLTGAGGG
Sbjct: 297 LDKDGA------FKSLGELVDINQQLLYVIGVSHPAINNIVRSAAAYKI-HAKLTGAGGG 349
Query: 356 GCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAK 402
GC LL DI ++ + + + L +YE++ T LG G + +K
Sbjct: 350 GCVFALLPPDIPKDSVKALQADLFRH-NYESWITSLGAHGVMMHRSK 395
>gb|AAX46713.1| mevalonate kinase [Bos taurus]
Length = 440
Score = 352 bits (903), Expect = 4e-95, Method: Composition-based stats.
Identities = 124/406 (30%), Positives = 207/406 (50%), Gaps = 36/406 (8%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFN 60
+S L SAPGKVI+ GEH+ V+ K A+A +++ LRT+L + S + L+ P+I
Sbjct: 2 LSEALLVSAPGKVILHGEHAVVHGKVALAMALN-LRTFLRLQPHSN-GRVGLNLPNIGVR 59
Query: 61 HKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLY 120
W + + + A +E+ + + A FLY
Sbjct: 60 RAWDVASLQLLDTSFLGHGDSAALTAKHVEKLKEVAGFPKDCVDP-----EHLAVLAFLY 114
Query: 121 MFVCLCPH---AKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLI-----GSNDL 172
+++ +C ++ ++ S LP GAGLGSSA+ SV LA A+ I
Sbjct: 115 LYLSICQSQRALPSLDITVWSELPTGAGLGSSAAYSVCLAAALLTACEEIPNPLKDGEAA 174
Query: 173 EKLSENDKHIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLD 232
+ +E + ++N+WAF GE+ IHG PSG+DNAV+T+G AL +++ L
Sbjct: 175 GRWTEENLELINKWAFQGERVIHGNPSGVDNAVSTWGGALRYQQG---------KISSLK 225
Query: 233 DFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSK 292
P + ++L T++PRSTK LVA VR + KFPE++ P+L ++ +L+ ++ +++
Sbjct: 226 RPPVLKILLINTKVPRSTKVLVANVRSRLL-KFPEIVAPLLTSIDAISLECERVLGEMAA 284
Query: 293 CKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGA 352
E Y L ELI +N L ++GV H L+ + ++ +KLTGA
Sbjct: 285 AP---------TPEHYLTLEELIDMNQHHLNALGVGHASLDQLCQVTTAHG-LHSKLTGA 334
Query: 353 GGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCL 398
GGGGC +TLLR D+ + ++++ K+ L + ++ +ET +G G +
Sbjct: 335 GGGGCGITLLRPDVERPEVEATKRALSG-YGFDCWETSVGAPGVSV 379
>ref|XP_001364115.1| PREDICTED: similar to mevalonate kinase [Monodelphis domestica]
Length = 396
Score = 351 bits (900), Expect = 9e-95, Method: Composition-based stats.
Identities = 133/414 (32%), Positives = 215/414 (51%), Gaps = 32/414 (7%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFN 60
+ L SAPGKVI+ GEH+ V+ K A+A +++ LRT+L + + L P++ +
Sbjct: 2 LPETLLVSAPGKVILHGEHAVVHGKVALAEALN-LRTFLRMRPHK-DGKVRLVLPNLETS 59
Query: 61 HKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLY 120
+W ++ + ++S + T ++L + + AF +LY
Sbjct: 60 REWDVSKLQLLHASFLDSG---EPTAPTTEQVEKLKAFAGFMTGSSERECLAVLAFLYLY 116
Query: 121 MFVCLCPH-AKNIKFSLKSTLPIGAGLGSSASISVSLALAMAY-----LGGLIGSNDLEK 174
+F+C ++ + S LP GAGLGSSA+ SV LA A+ + L +
Sbjct: 117 LFICRKHRPLPSMDIVVWSELPTGAGLGSSAAYSVCLAAALLASCEEIMNRLKEGATSAR 176
Query: 175 LSENDKHIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLDDF 234
+E++ +++N+WAF+GEK IHG PSG+DN+V+T+G AL F+K N L
Sbjct: 177 WNEDELNLINRWAFLGEKVIHGNPSGVDNSVSTWGGALRFQKG---------NISSLQRI 227
Query: 235 PAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSKCK 294
P + ++LT T++PRSTK LVA V+ + KFPE+M P+L ++ + + ++ +
Sbjct: 228 PVLKILLTNTKVPRSTKALVASVKDRLA-KFPEIMNPLLVSIDAISQECERVLGVM---- 282
Query: 295 GTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGAGG 354
A E Y L ELI +N L +IGV H L+ + ++ +KLTGAGG
Sbjct: 283 -----AATPTPEQYMVLEELIDMNQHHLNAIGVGHSSLDRLCQVTAAHG-LHSKLTGAGG 336
Query: 355 GGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLNKDL 408
GGC TLLR + Q +++ K+ L +E +ET +GG G L S +L ++
Sbjct: 337 GGCGFTLLRPGLDQSVVEAIKQALT-SCGFECWETTIGGPGVSLHSEASLKANV 389
>ref|XP_001496887.1| PREDICTED: similar to mevalonate kinase [Equus caballus]
Length = 407
Score = 346 bits (889), Expect = 1e-93, Method: Composition-based stats.
Identities = 129/419 (30%), Positives = 213/419 (50%), Gaps = 41/419 (9%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFN 60
+S L SAPGKVI+ GEH+ V+ K A+A +++ LRT+L + S + L+ P+I
Sbjct: 12 LSEVLLVSAPGKVILHGEHAVVHGKVALAVALN-LRTFLRLQPHST-GKVGLNLPNIGIK 69
Query: 61 HKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLL---AQLSESFHYHAAFC 117
W + + + Q L+ E V L + + + A
Sbjct: 70 QAWDVASLQLLDTSFLE-------QGDITALTPEQVEKLKEVAGCPEDCANDHKWLAVLA 122
Query: 118 FLYMFVCLCPH---AKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYL-----GGLIGS 169
FL++++ +C ++ ++ S LP GAGLGSSA+ SV LA A L
Sbjct: 123 FLFLYLSICRKQRALPSLDVTVWSELPPGAGLGSSAAYSVCLAAAFLAACEEIPNPLKDG 182
Query: 170 NDLEKLSENDKHIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFK 229
+ +E D ++N+WAF GE+ IHG PSG+DN V+T+G AL +++
Sbjct: 183 EPTSRWTEEDLELINKWAFQGERVIHGNPSGVDNTVSTWGGALRYQQG---------KIS 233
Query: 230 FLDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTK 289
L PA+ ++LT T++PRSTK LVA VR + KFPE++ P+L ++ +L+ ++ +
Sbjct: 234 SLKRPPALKILLTNTKVPRSTKALVAGVRNRLL-KFPEIVAPVLTSIEAISLECERVLAE 292
Query: 290 LSKCKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKL 349
+ A Y L ELI +N L ++GV H L+ + ++ +KL
Sbjct: 293 M---------ASAPTPGHYLVLEELIDMNQHHLNALGVGHASLDQLCQVTTAHG-LHSKL 342
Query: 350 TGAGGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLNKDL 408
TG GGGGC +TLLR D+ + ++++ K+ L ++ +ET +G G + +A +L+ +
Sbjct: 343 TGGGGGGCGITLLRPDLQRLEVEAAKQALTG-CGFDCWETSIGAPGVSVHAATSLDAPI 400
>ref|NP_112325.1| mevalonate kinase [Rattus norvegicus]
sp|P17256|KIME_RAT Mevalonate kinase (MK)
pdb|1KVK|A Chain A, The Structure Of Binary Complex Between A Mammalian
Mevalonate Kinase And Atp: Insights Into The Reaction
Mechanism And Human Inherited Disease
gb|AAA41588.1| mevalonate kinase (EC 2.7.1.36)
gb|EDM13937.1| mevalonate kinase, isoform CRA_a [Rattus norvegicus]
Length = 395
Score = 345 bits (886), Expect = 4e-93, Method: Composition-based stats.
Identities = 119/414 (28%), Positives = 205/414 (49%), Gaps = 30/414 (7%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFN 60
+S L SAPGKVI+ GEH+ V+ K A+A +++ LRT+L++ S + L+ P++
Sbjct: 2 LSEVLLVSAPGKVILHGEHAVVHGKVALAVALN-LRTFLVLRPQSN-GKVSLNLPNVGIK 59
Query: 61 HKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLY 120
W + + + + +++ L + +E A
Sbjct: 60 QVWDVATLQLLDTGFLEQGDVPAPTLEQLEKLKKVAGLPRDCVG--NEGLSLLAFLYLYL 117
Query: 121 MFVCLCPHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGG-----LIGSNDLEKL 175
++ + S LP GAGLGSSA+ SV +A A+ L +
Sbjct: 118 AICRKQRTLPSLDIMVWSELPPGAGLGSSAAYSVCVAAALLTACEEVTNPLKDRGSIGSW 177
Query: 176 SENDKHIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLDDFP 235
E D +N+WA+ GE+ IHG PSG+DN+V+T+G AL +++ L P
Sbjct: 178 PEEDLKSINKWAYEGERVIHGNPSGVDNSVSTWGGALRYQQG---------KMSSLKRLP 228
Query: 236 AIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSKCKG 295
A+ ++LT T++PRSTK LVA VR + KFPE+M P+L ++ +L+ ++ +++
Sbjct: 229 ALQILLTNTKVPRSTKALVAGVRSRLI-KFPEIMAPLLTSIDAISLECERVLGEMAAAPV 287
Query: 296 TDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGAGGG 355
E Y L EL+ +N L ++GV H L+ + ++ +KLTGAGGG
Sbjct: 288 ---------PEQYLVLEELMDMNQHHLNALGVGHASLDQLCQVTAAHG-LHSKLTGAGGG 337
Query: 356 GCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLNKDLK 409
GC +TLL+ + + ++++ K+ L ++ +ET +G G + SA ++ ++
Sbjct: 338 GCGITLLKPGLERAKVEAAKQALTG-CGFDCWETSIGAPGVSMHSATSIEDPVR 390
>ref|XP_500956.1| hypothetical protein [Yarrowia lipolytica]
emb|CAG83209.1| unnamed protein product [Yarrowia lipolytica CLIB122]
Length = 449
Score = 345 bits (885), Expect = 5e-93, Method: Composition-based stats.
Identities = 161/430 (37%), Positives = 237/430 (55%), Gaps = 44/430 (10%)
Query: 3 LPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLIS-ESSAPDTIELDFPDISFNH 61
+ ++ SAPGKVI+FGEH+AV+ KPA+AA++ LRTYLL+ +S T+ L+FPDI N
Sbjct: 1 MDYIISAPGKVILFGEHAAVFGKPAIAAAID-LRTYLLVETTTSDTPTVTLEFPDIHLNF 59
Query: 62 KWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLYM 121
K ++ ++T + D + +S L L A FLY+
Sbjct: 60 KVQVDKLASLTAQTKADHLNWSTPKTLDKHIFDSLSSLALLEEPGLTKVQQAAVVSFLYL 119
Query: 122 FVCLCPHA---KNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLIG---SNDLEKL 175
++ LCP + + + ++STLPIGAGLGSSASI V LA + L G + + D + L
Sbjct: 120 YIHLCPPSVCEDSSNWVVRSTLPIGAGLGSSASICVCLAAGLLVLNGQLSIDQARDFKSL 179
Query: 176 SENDKHIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLDDFP 235
+E +V+ W+F+GE CIHG PSGIDNAVAT G ALLF++ NN L D P
Sbjct: 180 TEKQLSLVDDWSFVGEMCIHGNPSGIDNAVATQGGALLFQR--------PNNRVPLVDIP 231
Query: 236 AIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSKCKG 295
+ ++LT T+ PRST DLV V VL E F +M PI+ ++GE + Q +EI+++ K
Sbjct: 232 EMKLLLTNTKHPRSTADLVGGVGVLTKE-FGSIMDPIMTSVGEISNQAMEIISRGKKMVD 290
Query: 296 -----------------------TDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGL 332
D ++ ++ ++ L+RINHGLL+++GVSHP L
Sbjct: 291 QSNLEIEQGILPQPTSEDACNVMEDGATLQKLRDIGSEMQHLVRINHGLLIAMGVSHPKL 350
Query: 333 ELIKNLSDDLRIGSTKLTGAGGGGCSLTLL-RRDITQEQIDSFKKKLQDD---FSYETFE 388
E+I+ S +G TKLTGAGGGGC++TL+ +D T Q++ ++ +E E
Sbjct: 351 EIIRTASIVHNLGETKLTGAGGGGCAITLVTSKDKTATQLEENVIAFTEEMATHGFEVHE 410
Query: 389 TDLGGTGCCL 398
T +G G +
Sbjct: 411 TTIGARGVGM 420
>ref|NP_076045.1| mevalonate kinase [Mus musculus]
sp|Q9R008|KIME_MOUSE Mevalonate kinase (MK)
gb|AAF00700.1|AF137598_1 mevalonate kinase [Mus musculus]
gb|AAH05606.1| Mevalonate kinase [Mus musculus]
Length = 395
Score = 341 bits (874), Expect = 8e-92, Method: Composition-based stats.
Identities = 126/414 (30%), Positives = 206/414 (49%), Gaps = 30/414 (7%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFN 60
+S L SAPGKVI+ GEH+ V+ K A+AA+++ LRT+LL+ S + ++ P+I
Sbjct: 2 LSEALLVSAPGKVILHGEHAVVHGKVALAAALN-LRTFLLLRPQSN-GKVSVNLPNIGIK 59
Query: 61 HKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLY 120
W + + + ++ +++ L P +E A
Sbjct: 60 QVWDVGMLQRLDTSFLEQGDVSVPTLEQLEKLKKMGDL--PRDRAGNEGMALLAFLYLYL 117
Query: 121 MFVCLCPHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLIGSN-----DLEKL 175
++ + S LP GAGLGSSA+ SV LA A+ + + + +
Sbjct: 118 AICRKQRTLPSLDMVVWSELPPGAGLGSSAAYSVCLAAALLTACEEVSNPLKDGVSVSRW 177
Query: 176 SENDKHIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLDDFP 235
E D +N+WAF GE+ IHG PSG+DNAV+T+G AL F++ L P
Sbjct: 178 PEEDLKSINKWAFEGERVIHGNPSGVDNAVSTWGGALRFQQG---------TMSSLKSLP 228
Query: 236 AIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSKCKG 295
++ ++LT T++PRSTK LVA VR +T KFPE++ P+L ++ +L+ ++ ++
Sbjct: 229 SLQILLTNTKVPRSTKALVAAVRSRLT-KFPEIVAPLLTSIDAISLECERVLGEMVAAPV 287
Query: 296 TDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGAGGG 355
E Y L ELI +N L ++GV H L+ + ++ +KLTGAGGG
Sbjct: 288 ---------PEQYLVLEELIDMNQHHLNALGVGHNSLDQLCQVTAAHG-LHSKLTGAGGG 337
Query: 356 GCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLNKDLK 409
GC +TLL+ + Q +++ K+ L ++ +ET +G G SA + ++
Sbjct: 338 GCGITLLKPGLEQATVEAAKQALT-SCGFDCWETSIGAPGVSTHSAAAVGDPVR 390
>dbj|BAE28997.1| unnamed protein product [Mus musculus]
Length = 407
Score = 341 bits (874), Expect = 9e-92, Method: Composition-based stats.
Identities = 127/424 (29%), Positives = 206/424 (48%), Gaps = 38/424 (8%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFN 60
+S L SAPGKVI+ GEH+ V+ K A+AA+++ LRT+LL+ S + ++ P+I
Sbjct: 2 LSEALLVSAPGKVILHGEHAVVHGKVALAAALN-LRTFLLLRPQSN-GKVSVNLPNIGIK 59
Query: 61 HKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLD----------PLLAQLSESF 110
W + + + + T+ + +L P +E
Sbjct: 60 QVWDVGMLQRLDTSFLGLSPTCLFARVTEQGDVSVPTLEQLEKLKKMGDLPRDRAGNEGM 119
Query: 111 HYHAAFCFLYMFVCLCPHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLIGSN 170
A ++ + S LP GAGLGSSA+ SV LA A+ + +
Sbjct: 120 ALLAFLYLYLAICRKQRTLPSLDMVVWSELPPGAGLGSSAAYSVCLAAALLTACEEVSNP 179
Query: 171 -----DLEKLSENDKHIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINT 225
+ + E D +N+WAF GE+ IHG PSG+DNAV+T+G AL F++
Sbjct: 180 LKDGVSVSRWPEEDLKSINKWAFEGERVIHGNPSGVDNAVSTWGGALRFQQG-------- 231
Query: 226 NNFKFLDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLE 285
L P++ ++LT T++PRSTK LVA VR +T KFPE++ P+L ++ +L+
Sbjct: 232 -TMSSLKSLPSLQILLTNTKVPRSTKALVAAVRSRLT-KFPEIVAPLLTSIDAISLECER 289
Query: 286 IMTKLSKCKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIG 345
++ ++ E Y L ELI +N L ++GV H L+ + ++
Sbjct: 290 VLGEMVAAPV---------PEQYLVLEELIDMNQHHLNALGVGHNSLDQLCQVTAAHG-L 339
Query: 346 STKLTGAGGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLN 405
+KLTGAGGGGC +TLL+ + Q +++ K+ L ++ +ET +G G SA +
Sbjct: 340 HSKLTGAGGGGCGITLLKPGLEQATVEAAKQALT-SCGFDCWETSIGAPGVSTHSAAAVG 398
Query: 406 KDLK 409
++
Sbjct: 399 DPVR 402
>ref|XP_001628178.1| predicted protein [Nematostella vectensis]
gb|EDO36115.1| predicted protein [Nematostella vectensis]
Length = 415
Score = 338 bits (866), Expect = 7e-91, Method: Composition-based stats.
Identities = 136/431 (31%), Positives = 211/431 (48%), Gaps = 44/431 (10%)
Query: 1 MSLP-FLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISF 59
M L + SAPGK+I+ GEH+ VY K A+A S+ LRT +++ + L D+ +
Sbjct: 1 MKLSRVVVSAPGKIILHGEHAVVYGKAAIAVSI-GLRTTVVLQRHKNESKVSLLLKDLDY 59
Query: 60 NHKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQ---LSESFHYHAAF 116
W + D I V ++++ E++SL+D L+ + AA
Sbjct: 60 ILTWDLTDIQKIL---VAVPQVSRTDTVLPS--DEMLSLIDKLIDSSKFVEVEGVKDAAR 114
Query: 117 CFLYMFVCLC---PHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLI------ 167
FL++ I+ +K+ LP+GAGLGSSA+ S+SLA AM I
Sbjct: 115 VFLFLMTSTLRDRDRLPAIEVEVKTALPLGAGLGSSAAYSISLAAAMLLSMQTIPLPKYV 174
Query: 168 -------------GSNDLEKLSENDKHIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLF 214
S + + +V QWAF EK +HG PSGIDN++ATYG ALLF
Sbjct: 175 KKTPESETTAKDTDSYQYDDIETESLRLVCQWAFEAEKIMHGQPSGIDNSIATYGGALLF 234
Query: 215 EKDSHNGTINTNNFKFLDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILD 274
+ L+ P + ++L T+IPRST+ +VA VR E FP V + +
Sbjct: 235 QNGE---------ITHLESMPLLSILLIDTQIPRSTRVMVAGVRDRYIE-FPTVYMSLFE 284
Query: 275 AMGECALQGLEIMTKLSKCKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLEL 334
A+ + ++I +K+ K D E Y++L L+ +N LL GVSHP L+
Sbjct: 285 AVDGICHECIKIFSKIHNLKNEDVPKSEFVR-YYQRLESLVDVNQQLLSLFGVSHPSLDS 343
Query: 335 IKNLSDDLRIGSTKLTGAGGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGT 394
+ +++ TKLTGAGGGGC++TL+ ++++ KLQ +F Y+ ++T LG
Sbjct: 344 LCHMTSKYG-LHTKLTGAGGGGCAITLIPPGTDKDKVAELMNKLQKEFKYKVWQTPLGSR 402
Query: 395 GCCLLSAKNLN 405
G + A ++
Sbjct: 403 GVIVHEAIPVD 413
>emb|CAM15186.1| novel protein similar to vertebrate mevalonate kinase (mevalonic
aciduria) (MVK) [Danio rerio]
Length = 396
Score = 337 bits (864), Expect = 1e-90, Method: Composition-based stats.
Identities = 136/415 (32%), Positives = 218/415 (52%), Gaps = 36/415 (8%)
Query: 2 SLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFNH 61
S SAPGKVI+ GEHS V+ K A+A SV+ LRTYL + +S++ + ++ P+I
Sbjct: 3 SRELFVSAPGKVILHGEHSVVHGKVALAVSVN-LRTYLRL-QSTSSGQVCINLPNIDTFL 60
Query: 62 KWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPL--LAQLSESFHYHAAFCFL 119
W I + Q+ K L +L+ L ++ S A FL
Sbjct: 61 SWEITALQPLLAGSKAEQRDPK------ELDADLLKKLREFTGISDDSTDTRSMAVLAFL 114
Query: 120 YMFVCLCPHA-KNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLIGS-----NDLE 173
YM++ + + +I S+ S LP GAGLGSSA+ +V L+ A+ G I +
Sbjct: 115 YMYITVFAESLASITVSVWSELPTGAGLGSSAAYNVCLSAALLSARGNISPLLMAQQESA 174
Query: 174 KLSENDKHIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLDD 233
+ S+++ ++N+WAF+GEK IHG PSG+DNAV T+G L + ++ N L
Sbjct: 175 RWSKDEMELINRWAFMGEKIIHGNPSGVDNAVGTWGGFLRY---------HSGNITPLSW 225
Query: 234 FPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSKC 293
P + ++LT T++PRSTK LV+ V+ + KFP VM+P+L+++ + + +T++++
Sbjct: 226 VPILRILLTNTKVPRSTKVLVSGVKDKI-NKFPSVMRPVLESVSAVSCTCEQTLTEMAEH 284
Query: 294 KGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGAG 353
+ E Y L ELI IN L +GV H L+ + ++ +KLTGAG
Sbjct: 285 G--------PSAEHYNILEELIDINQHHLNVMGVGHSSLDTLCRVTLSKG-LHSKLTGAG 335
Query: 354 GGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLNKDL 408
GGGC +TLLR + I S ++L+ ++ +ET +G G S+ ++ D+
Sbjct: 336 GGGCGITLLRPETDTSVIQSTVEELK-ACGFDCWETSIGAPGVQQHSSAAISPDV 389
>ref|NP_001007350.1| hypothetical protein LOC492477 [Danio rerio]
gb|AAH85528.1| Zgc:103473 [Danio rerio]
gb|AAI64491.1| Zgc:103473 protein [synthetic construct]
Length = 396
Score = 336 bits (862), Expect = 2e-90, Method: Composition-based stats.
Identities = 136/415 (32%), Positives = 218/415 (52%), Gaps = 36/415 (8%)
Query: 2 SLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFNH 61
S SAPGKVI+ GEHS V+ K A+A SV+ LRTYL + +S++ + ++ P+I
Sbjct: 3 SRELFVSAPGKVILHGEHSVVHGKVALAVSVN-LRTYLRL-QSTSSGQVCINLPNIDTFL 60
Query: 62 KWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPL--LAQLSESFHYHAAFCFL 119
W I + Q+ K L +L+ L ++ S A FL
Sbjct: 61 SWEITALQPLLAGSKAEQRDPK------ELDADLLKKLREFTGISDDSTDTRSMAVLAFL 114
Query: 120 YMFVCLCPHA-KNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLIGS-----NDLE 173
YM++ + + +I S+ S LP GAGLGSSA+ +V L+ A+ G I +
Sbjct: 115 YMYLTVFAESLASITVSVWSELPTGAGLGSSAAYNVCLSAALLSARGNISPLLMAQQESA 174
Query: 174 KLSENDKHIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLDD 233
+ S+++ ++N+WAF+GEK IHG PSG+DNAV T+G L + ++ N L
Sbjct: 175 RWSKDEMELINRWAFMGEKIIHGNPSGVDNAVGTWGGFLRY---------HSGNITPLSW 225
Query: 234 FPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSKC 293
P + ++LT T++PRSTK LV+ V+ + KFP VM+P+L+++ + + +T++++
Sbjct: 226 VPILRILLTNTKVPRSTKVLVSGVKDKI-NKFPSVMRPVLESVSAVSCTCEQTLTEMAEH 284
Query: 294 KGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGAG 353
+ E Y L ELI IN L +GV H L+ + ++ +KLTGAG
Sbjct: 285 G--------PSAEHYNILEELIDINQHHLNVMGVGHSSLDTLCRVTLSKG-LHSKLTGAG 335
Query: 354 GGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLNKDL 408
GGGC +TLLR + I S ++L+ ++ +ET +G G S+ ++ D+
Sbjct: 336 GGGCGITLLRPETDTSVIQSAVEELK-ACGFDCWETSIGAPGVQQHSSAAISPDV 389
>ref|XP_001540400.1| conserved hypothetical protein [Ajellomyces capsulatus NAm1]
gb|EDN07730.1| conserved hypothetical protein [Ajellomyces capsulatus NAm1]
Length = 411
Score = 333 bits (853), Expect = 2e-89, Method: Composition-based stats.
Identities = 133/363 (36%), Positives = 195/363 (53%), Gaps = 26/363 (7%)
Query: 48 DTIELDFPDISFNHKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLS 107
TI L+F DI +H W I+ + +K + L EL+ + P +A +S
Sbjct: 8 RTITLNFRDIELDHTWDIDSLPWELFHHPSKKKFYYSS--VTSLDTELLEAIQPHIADIS 65
Query: 108 -------ESFHYHAAFCFLYMFVCLC-PHAKNIKFSLKSTLPIGAGLGSSASISVSLALA 159
H +A FLY+F+ L P ++L+ST+PIGAGLGSSASI+V L+ A
Sbjct: 66 IGKPDEVRKIHQSSATAFLYLFLSLSSPQTHAAVYTLRSTIPIGAGLGSSASIAVCLSAA 125
Query: 160 MA-YLGGLIGSNDLEKLSENDKHI--VNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEK 216
+ + L G + + E + I +N+WAF+GE CIHG PSG+DN V+ G A++F +
Sbjct: 126 LLLQIRILAGPHQDQLPEEAETQIERINKWAFVGEMCIHGNPSGVDNTVSAGGKAVIFRR 185
Query: 217 DSHNGTINTNNFKFLDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAM 276
++ + + DFP +P++L +R PRST VA+V P V + IL+A+
Sbjct: 186 GDYS---KPPSVTPILDFPELPLLLVNSRQPRSTSVEVAKVANFCK-AHPAVSESILEAI 241
Query: 277 GECALQGLEIMTKLSKCKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIK 336
+ ++ ++++E + EL RINHGLLVS+GVSHP LE I+
Sbjct: 242 DQVTESASNLIQ--------SGRFDKSSSEAIDHFGELFRINHGLLVSLGVSHPRLERIR 293
Query: 337 NLSDDLRIGSTKLTGAGGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGC 396
L D G TKLTGAGGGGC++TLLR + + +K L DD +E +ET LGG G
Sbjct: 294 ELVDHTGSGWTKLTGAGGGGCAITLLRTNTDPAALKRLEKTL-DDEGFERYETILGGHGI 352
Query: 397 CLL 399
+L
Sbjct: 353 GVL 355
Searching..................................................done
Results from round 3
Score E
Sequences producing significant alignments: (bits) Value
Sequences used in model and found again:
gb|EDN64144.1| mevalonate kinase [Saccharomyces cerevisiae ... 504 e-141
ref|NP_013935.1| Mevalonate kinase, acts in the biosynthesi... 504 e-141
ref|XP_460851.1| hypothetical protein DEHA0F12188g [Debaryo... 378 e-103
ref|XP_001644409.1| hypothetical protein Kpol_1064p33 [Vand... 372 e-101
ref|XP_001229023.1| hypothetical protein CHGG_02507 [Chaeto... 371 e-101
ref|XP_001593159.1| hypothetical protein SS1G_06081 [Sclero... 370 e-101
ref|XP_001911734.1| unnamed protein product [Podospora anse... 366 2e-99
ref|XP_386088.1| hypothetical protein FG05912.1 [Gibberella... 365 5e-99
ref|XP_001382664.2| mevalonate kinase [Pichia stipitis CBS ... 363 2e-98
ref|XP_723495.1| mevalonate kinase [Candida albicans SC5314... 362 4e-98
ref|XP_001559870.1| hypothetical protein BC1G_01429 [Botryo... 361 5e-98
ref|XP_961360.1| hypothetical protein NCU03633 [Neurospora ... 361 7e-98
ref|XP_001527900.1| hypothetical protein LELG_00420 [Lodder... 358 7e-97
ref|XP_001214601.1| conserved hypothetical protein [Aspergi... 356 2e-96
ref|NP_985191.1| AER335Wp [Ashbya gossypii ATCC 10895] >gi|... 356 3e-96
ref|XP_661473.1| hypothetical protein AN3869.2 [Aspergillus... 355 3e-96
ref|XP_752047.1| mevalonate kinase [Aspergillus fumigatus A... 355 3e-96
ref|XP_001271672.1| mevalonate kinase [Aspergillus clavatus... 355 4e-96
ref|XP_001821298.1| hypothetical protein [Aspergillus oryza... 355 4e-96
ref|XP_001267243.1| mevalonate kinase [Neosartorya fischeri... 355 5e-96
gb|EDP50156.1| mevalonate kinase [Aspergillus fumigatus A1163] 355 5e-96
gb|EEH48028.1| mevalonate kinase [Paracoccidioides brasilie... 355 5e-96
ref|XP_001241830.1| hypothetical protein CIMG_05726 [Coccid... 353 2e-95
ref|XP_001401587.1| hypothetical protein An04g02190 [Asperg... 352 3e-95
ref|XP_370449.1| hypothetical protein MGG_06946 [Magnaporth... 350 2e-94
ref|XP_446138.1| unnamed protein product [Candida glabrata]... 350 2e-94
ref|XP_452532.1| unnamed protein product [Kluyveromyces lac... 345 5e-93
ref|XP_001483309.1| hypothetical protein PGUG_04038 [Pichia... 336 1e-90
gb|EEH37797.1| mevalonate kinase [Paracoccidioides brasilie... 326 2e-87
emb|CAA53059.1| unnamed protein product [Hepatitis B virus] 320 1e-85
ref|XP_001105759.1| PREDICTED: mevalonate kinase isoform 2 ... 317 1e-84
gb|AAX08684.1| mevalonate kinase [Bos taurus] 310 1e-82
ref|NP_001015528.1| mevalonate kinase [Bos taurus] >gi|7506... 310 2e-82
dbj|BAD92959.1| mevalonate kinase variant [Homo sapiens] 309 2e-82
ref|NP_000422.1| mevalonate kinase [Homo sapiens] >gi|16700... 309 3e-82
gb|AAQ02416.1| mevalonate kinase [synthetic construct] 309 4e-82
ref|XP_543435.2| PREDICTED: similar to Mevalonate kinase (M... 306 2e-81
ref|NP_112325.1| mevalonate kinase [Rattus norvegicus] >gi|... 306 3e-81
gb|AAX46713.1| mevalonate kinase [Bos taurus] 305 3e-81
ref|XP_790690.1| PREDICTED: similar to Mevalonate kinase (M... 305 7e-81
ref|NP_076045.1| mevalonate kinase [Mus musculus] >gi|89281... 305 7e-81
ref|XP_001364115.1| PREDICTED: similar to mevalonate kinase... 300 1e-79
ref|XP_001496887.1| PREDICTED: similar to mevalonate kinase... 300 2e-79
dbj|BAE28997.1| unnamed protein product [Mus musculus] 298 5e-79
ref|XP_001628178.1| predicted protein [Nematostella vectens... 296 2e-78
ref|XP_500956.1| hypothetical protein [Yarrowia lipolytica]... 295 5e-78
ref|NP_592837.1| mevalonate kinase Erg12 (predicted) [Schiz... 287 1e-75
ref|XP_001540400.1| conserved hypothetical protein [Ajellom... 284 1e-74
gb|EDU45497.1| mevalonate kinase [Pyrenophora tritici-repen... 283 3e-74
gb|AAD45421.1|L77688_1 mevalonate kinase [Arabidopsis thali... 281 5e-74
emb|CAM15186.1| novel protein similar to vertebrate mevalon... 280 1e-73
ref|NP_001007350.1| hypothetical protein LOC492477 [Danio r... 279 2e-73
ref|NP_198097.1| MK/MVK; mevalonate kinase [Arabidopsis tha... 279 3e-73
emb|CAG08527.1| unnamed protein product [Tetraodon nigrovir... 279 3e-73
ref|XP_567851.1| cystathionine beta-lyase [Cryptococcus neo... 274 8e-72
emb|CAO17636.1| unnamed protein product [Vitis vinifera] 274 1e-71
ref|XP_567850.1| cystathionine beta-lyase [Cryptococcus neo... 273 2e-71
dbj|BAA24409.1| mevalonate kinase [Saccharomyces cerevisiae] 272 4e-71
ref|XP_001836355.1| hypothetical protein CC1G_06440 [Coprin... 270 1e-70
gb|ABK95983.1| unknown [Populus trichocarpa] 270 2e-70
ref|XP_001846214.1| mevalonate kinase [Culex pipiens quinqu... 267 1e-69
ref|XP_761643.1| hypothetical protein UM05496.1 [Ustilago m... 266 2e-69
ref|YP_001334437.1| galactokinase [Klebsiella pneumoniae su... 266 2e-69
gb|AAX07752.1| galactokinase [Klebsiella pneumoniae] 266 3e-69
ref|ZP_02700220.1| galactokinase [Salmonella enterica subsp... 266 3e-69
gb|AAL18925.1|AF429384_1 mevalonate kinase [Hevea brasilien... 265 6e-69
ref|XP_001779131.1| predicted protein [Physcomitrella paten... 265 6e-69
ref|NP_001093299.1| mevalonate kinase [Bombyx mori] >gi|146... 265 6e-69
ref|NP_349561.1| galactokinase [Clostridium acetobutylicum ... 264 7e-69
ref|ZP_02665563.1| galactokinase [Salmonella enterica subsp... 264 9e-69
ref|NP_459753.1| galactokinase [Salmonella typhimurium LT2]... 264 9e-69
ref|ZP_02561120.1| galactokinase [Salmonella enterica subsp... 264 1e-68
gb|EAW89316.1| galactokinase 1 [Homo sapiens] 264 1e-68
ref|NP_455316.1| galactokinase [Salmonella enterica subsp. ... 264 1e-68
ref|ZP_02344312.1| galactokinase [Salmonella enterica subsp... 264 1e-68
ref|YP_001588958.1| hypothetical protein SPAB_02747 [Salmon... 264 1e-68
ref|ZP_02649015.1| galactokinase [Salmonella enterica subsp... 264 1e-68
ref|ZP_02341305.1| galactokinase [Salmonella enterica subsp... 264 1e-68
ref|YP_215759.1| galactokinase [Salmonella enterica subsp. ... 264 1e-68
ref|YP_001571187.1| hypothetical protein SARI_02168 [Salmon... 263 2e-68
ref|NP_001064360.1| Os10g0329300 [Oryza sativa (japonica cu... 263 2e-68
ref|ZP_02950336.1| galactokinase [Clostridium butyricum 552... 263 2e-68
ref|ZP_02564893.1| galactokinase [Salmonella enterica subsp... 263 2e-68
ref|YP_151198.1| galactokinase [Salmonella enterica subsp. ... 263 3e-68
ref|NP_000145.1| galactokinase 1 [Homo sapiens] >gi|1730187... 263 3e-68
ref|XP_001608063.1| PREDICTED: similar to mevalonate kinase... 262 3e-68
gb|AAP36280.1| Homo sapiens galactokinase 1 [synthetic cons... 262 4e-68
ref|YP_001662721.1| galactokinase [Thermoanaerobacter sp. X... 262 5e-68
ref|XP_001105689.1| PREDICTED: mevalonate kinase isoform 1 ... 261 1e-67
ref|YP_001664603.1| galactokinase [Thermoanaerobacter pseud... 260 2e-67
ref|NP_001072199.1| hypothetical protein LOC779645 [Xenopus... 260 2e-67
ref|XP_001657825.1| mevalonate kinase [Aedes aegypti] >gi|1... 259 2e-67
ref|XP_645383.1| hypothetical protein DDBDRAFT_0168621 [Dic... 259 3e-67
gb|AAA27113.1| galactokinase (galK) (EC 2.7.1.6) 259 3e-67
gb|ABC98001.1| GalK [Shigella boydii] 259 3e-67
sp|A6H768|GALK1_BOVIN Galactokinase (Galactose kinase) 259 3e-67
gb|ABC98023.1| GalK [Shigella dysenteriae] 259 4e-67
ref|NP_001003104.1| galactokinase 1 [Canis lupus familiaris... 259 4e-67
gb|ABC98026.1| GalK [Shigella flexneri] 259 4e-67
gb|ABC98030.1| GalK [Shigella flexneri] >gi|86516678|gb|ABC... 259 4e-67
gb|ABC97999.1| GalK [Shigella boydii] 259 4e-67
ref|NP_001092851.1| galactokinase 1 [Bos taurus] >gi|148878... 259 4e-67
ref|NP_706484.1| galactokinase [Shigella flexneri 2a str. 3... 259 4e-67
ref|YP_402378.1| galactokinase [Shigella dysenteriae Sd197]... 258 5e-67
ref|NP_286478.1| galactokinase [Escherichia coli O157:H7 ED... 258 6e-67
ref|YP_001742860.1| galactokinase [Escherichia coli SMS-3-5... 258 6e-67
ref|NP_308812.1| galactokinase [Escherichia coli O157:H7 st... 258 6e-67
gb|ABC98013.1| GalK [Shigella boydii] 258 6e-67
ref|XP_001492114.1| PREDICTED: similar to galactokinase [Eq... 258 6e-67
ref|NP_001027412.1| CG33671 CG33671-PA [Drosophila melanoga... 258 7e-67
gb|ABC98032.1| GalK [Shigella flexneri] 258 7e-67
gb|AAA72509.1| galK 258 7e-67
gb|ABC98016.1| GalK [Shigella dysenteriae] >gi|86516650|gb|... 258 8e-67
ref|NP_752763.1| galactokinase [Escherichia coli CFT073] >g... 258 8e-67
gb|ABC97998.1| GalK [Shigella boydii] >gi|86516632|gb|ABC98... 258 9e-67
gb|ABC98018.1| GalK [Shigella dysenteriae] 258 1e-66
ref|NP_001085920.1| MGC82807 protein [Xenopus laevis] >gi|4... 257 1e-66
ref|ZP_02903417.1| galactokinase [Escherichia albertii TW07... 257 1e-66
ref|YP_001879407.1| galactokinase [Shigella boydii CDC 3083... 257 1e-66
ref|XP_624545.2| PREDICTED: similar to Mevalonate kinase (M... 257 1e-66
gb|ABC98038.1| GalK [Escherichia coli] 257 1e-66
ref|NP_058601.2| galactokinase 1 [Mus musculus] >gi|8650486... 257 1e-66
sp|Q9R0N0|GALK1_MOUSE Galactokinase (Galactose kinase) >gi|... 257 1e-66
gb|AAH50151.1| Galactokinase 1 [Mus musculus] 257 1e-66
dbj|BAB27400.1| unnamed protein product [Mus musculus] >gi|... 256 2e-66
ref|NP_001008283.1| galactokinase 1 [Rattus norvegicus] >gi... 256 2e-66
gb|ABC98014.1| GalK [Shigella dysenteriae] 256 2e-66
ref|ZP_00709332.1| COG0153: Galactokinase [Escherichia coli... 256 2e-66
gb|EEH92189.1| galactokinase [Citrobacter sp. 30_2] 256 2e-66
ref|YP_001175980.1| galactokinase [Enterobacter sp. 638] >g... 256 3e-66
ref|YP_407124.1| galactokinase [Shigella boydii Sb227] >gi|... 256 3e-66
ref|YP_001457550.1| galactokinase [Escherichia coli HS] >gi... 256 4e-66
ref|YP_688144.1| galactokinase [Shigella flexneri 5 str. 84... 255 4e-66
gb|AAC48872.1| galactokinase [Cloning vector pAL-Z] >gi|250... 255 6e-66
gb|ABC98007.1| GalK [Shigella boydii] 254 8e-66
ref|ZP_01189626.1| Galactokinase [Halothermothrix orenii H ... 254 8e-66
ref|ZP_02184438.1| galactokinase [Carnobacterium sp. AT7] >... 254 9e-66
ref|NP_623503.1| galactokinase [Thermoanaerobacter tengcong... 254 1e-65
ref|NP_143478.1| mevalonate kinase [Pyrococcus horikoshii O... 253 2e-65
ref|ZP_02272294.1| galactokinase [Fusobacterium nucleatum s... 253 2e-65
ref|NP_126232.1| mevalonate kinase [Pyrococcus abyssi GE5] ... 253 3e-65
ref|ZP_02914868.1| galactokinase [Geobacillus sp. WCH70] >g... 253 3e-65
dbj|BAB26864.1| unnamed protein product [Mus musculus] 253 3e-65
ref|ZP_00143687.1| Galactokinase [Fusobacterium nucleatum s... 252 3e-65
ref|YP_001126183.1| galactokinase [Geobacillus thermodenitr... 252 4e-65
ref|YP_001311484.1| galactokinase [Clostridium beijerinckii... 252 4e-65
ref|YP_183887.1| mevalonate kinase [Thermococcus kodakarens... 252 5e-65
ref|YP_001121649.1| galactokinase [Francisella tularensis s... 251 6e-65
ref|YP_514052.1| Galactokinase [Francisella tularensis subs... 251 8e-65
ref|NP_579366.1| mevalonate kinase [Pyrococcus furiosus DSM... 251 8e-65
ref|XP_001377585.1| PREDICTED: similar to galactokinase [Mo... 251 9e-65
ref|NP_602892.1| galactokinase [Fusobacterium nucleatum sub... 251 9e-65
ref|ZP_02954223.1| galactokinase [Clostridium perfringens D... 250 1e-64
ref|YP_148003.1| galactokinase [Geobacillus kaustophilus HT... 250 1e-64
ref|ZP_01967073.1| hypothetical protein RUMTOR_00615 [Rumin... 250 2e-64
ref|YP_170412.1| Galactokinase [Francisella tularensis subs... 250 2e-64
ref|YP_698665.1| galactokinase [Clostridium perfringens SM1... 249 2e-64
gb|EDN36035.1| galactokinase [Francisella tularensis subsp.... 249 2e-64
ref|YP_695995.1| galactokinase [Clostridium perfringens ATC... 249 3e-64
ref|ZP_02640523.1| galactokinase [Clostridium perfringens C... 249 3e-64
ref|XP_918559.1| PREDICTED: similar to mevalonate kinase [M... 249 3e-64
ref|ZP_02637705.1| galactokinase [Clostridium perfringens B... 249 3e-64
ref|ZP_03898469.1| galactokinase [Dyadobacter fermentans DS... 249 3e-64
ref|XP_001730996.1| hypothetical protein MGL_1995 [Malassez... 249 4e-64
ref|NP_562261.1| galactokinase [Clostridium perfringens str... 248 5e-64
ref|YP_898331.1| galactokinase [Francisella tularensis subs... 248 5e-64
ref|NP_391699.1| galactokinase [Bacillus subtilis subsp. su... 248 6e-64
ref|ZP_02863564.1| galactokinase [Clostridium perfringens C... 248 6e-64
gb|EDO66639.1| galactokinase [Francisella tularensis subsp.... 248 7e-64
gb|EDN37489.1| hypothetical protein FTDG_00277 [Francisella... 248 7e-64
gb|ABD32397.1| Mevalonate and galactokinase [Medicago trunc... 248 1e-63
ref|YP_001678584.1| galactokinase [Francisella philomiragia... 247 1e-63
ref|YP_001812878.1| galactokinase [Exiguobacterium sibiricu... 247 1e-63
ref|YP_001278123.1| galactokinase [Roseiflexus sp. RS-1] >g... 247 2e-63
ref|ZP_01169901.1| galactokinase [Bacillus sp. NRRL B-14911... 247 2e-63
ref|NP_001022868.1| Y42G9A.4c [Caenorhabditis elegans] >gi|... 246 4e-63
ref|ZP_03857040.1| galactokinase [Thermobaculum terrenum AT... 245 4e-63
ref|YP_001875501.1| galactokinase [Elusimicrobium minutum P... 245 5e-63
ref|NP_001022869.1| Y42G9A.4d [Caenorhabditis elegans] >gi|... 244 8e-63
ref|ZP_03968958.1| galactokinase [Sphingobacterium spiritiv... 244 8e-63
ref|NP_001022867.1| Y42G9A.4b [Caenorhabditis elegans] >gi|... 244 1e-62
ref|YP_001431124.1| galactokinase [Roseiflexus castenholzii... 244 1e-62
ref|ZP_02171442.1| binding-protein-dependent transport syst... 243 2e-62
ref|ZP_03852846.1| possible Galactokinase [Chryseobacterium... 243 2e-62
ref|ZP_03843333.1| galactokinase [Lactobacillus sakei subsp... 243 2e-62
ref|YP_395378.1| galactokinase [Lactobacillus sakei subsp. ... 243 2e-62
ref|ZP_02328484.1| galactokinase [Paenibacillus larvae subs... 243 2e-62
ref|ZP_02849316.1| galactokinase [Paenibacillus sp. JDR-2] ... 243 2e-62
ref|YP_001140151.1| galactokinase [Aeromonas salmonicida su... 243 3e-62
ref|NP_001006002.1| galactokinase 1 [Danio rerio] >gi|53734... 242 3e-62
ref|ZP_01885545.1| putative galactokinase [Pedobacter sp. B... 242 4e-62
ref|ZP_03948373.1| galactokinase [Enterococcus faecalis TX0... 242 4e-62
ref|XP_319701.4| AGAP008947-PA [Anopheles gambiae str. PEST... 242 4e-62
ref|YP_001420809.1| GalK1 [Bacillus amyloliquefaciens FZB42... 242 4e-62
ref|ZP_01059235.1| galactokinase [Flavobacterium sp. MED217... 242 5e-62
gb|AAL31086.1|AC091749_15 putative mevalonate kinase [Oryza... 242 5e-62
ref|NP_814801.1| galactokinase [Enterococcus faecalis V583]... 241 6e-62
ref|NP_578174.1| galactokinase [Pyrococcus furiosus DSM 363... 241 7e-62
ref|YP_920295.1| mevalonate kinase [Thermofilum pendens Hrk... 241 9e-62
ref|YP_098935.1| galactokinase [Bacteroides fragilis YCH46]... 241 1e-61
ref|YP_858529.1| galactokinase [Aeromonas hydrophila subsp.... 241 1e-61
ref|XP_972334.1| PREDICTED: similar to mevalonate kinase [T... 241 1e-61
ref|YP_001877582.1| galactokinase [Akkermansia muciniphila ... 240 2e-61
ref|YP_300719.1| galactokinase [Staphylococcus saprophyticu... 240 2e-61
ref|YP_803662.1| Galactokinase [Pediococcus pentosaceus ATC... 239 3e-61
gb|EEH98020.1| galactokinase [Clostridium sp. 7_2_43FAA] 239 4e-61
ref|ZP_01960689.1| hypothetical protein BACCAC_02307 [Bacte... 239 5e-61
gb|EEK05491.1| galactokinase [Alicyclobacillus acidocaldari... 239 5e-61
ref|XP_311991.3| AGAP002914-PA [Anopheles gambiae str. PEST... 238 6e-61
ref|XP_001600084.1| PREDICTED: similar to Galactokinase 1 [... 238 8e-61
ref|YP_862178.1| galactokinase [Gramella forsetii KT0803] >... 237 1e-60
ref|ZP_01106208.1| galactokinase [Flavobacteriales bacteriu... 237 1e-60
ref|ZP_03943398.1| possible mevalonate kinase [Lactobacillu... 237 2e-60
ref|YP_001928600.1| putative galactokinase [Porphyromonas g... 237 2e-60
ref|YP_081355.1| galactokinase [Bacillus licheniformis ATCC... 237 2e-60
gb|EEJ85937.1| galactokinase [Meiothermus ruber DSM 1279] 237 2e-60
pdb|1S4E|A Chain A, Pyrococcus Furiosus Galactokinase In Co... 236 3e-60
ref|YP_001423106.1| GalK [Bacillus amyloliquefaciens FZB42]... 236 3e-60
ref|YP_001095396.1| galactokinase [Shewanella loihica PV-4]... 236 4e-60
ref|NP_809283.1| galactokinase [Bacteroides thetaiotaomicro... 235 4e-60
ref|ZP_01994423.1| hypothetical protein DORLON_00408 [Dorea... 235 5e-60
ref|ZP_03940390.1| possible mevalonate kinase [Lactobacillu... 235 6e-60
ref|ZP_03954541.1| possible mevalonate kinase [Lactobacillu... 234 8e-60
emb|CAF89842.1| unnamed protein product [Tetraodon nigrovir... 234 8e-60
ref|YP_001547075.1| mevalonate kinase [Herpetosiphon aurant... 234 8e-60
ref|YP_001299606.1| galactokinase [Bacteroides vulgatus ATC... 234 1e-59
ref|NP_905758.1| galactokinase [Porphyromonas gingivalis W8... 234 1e-59
ref|ZP_02433505.1| hypothetical protein CLOSCI_03786 [Clost... 233 2e-59
ref|ZP_03923457.1| galactokinase [Mobiluncus curtisii ATCC ... 232 4e-59
ref|YP_001891490.1| galactokinase [Francisella tularensis s... 232 4e-59
ref|YP_001792272.1| galactokinase [Leptothrix cholodnii SP-... 232 5e-59
ref|ZP_00996819.1| galactokinase [Janibacter sp. HTCC2649] ... 231 7e-59
ref|ZP_02032306.1| hypothetical protein PARMER_02317 [Parab... 231 9e-59
ref|XP_798116.2| PREDICTED: similar to galactokinase 1 [Str... 231 1e-58
ref|XP_001662439.1| galactokinase [Aedes aegypti] >gi|10888... 231 1e-58
ref|NP_266560.1| mevalonate kinase [Lactococcus lactis subs... 230 2e-58
gb|EEJ90835.1| galactokinase [Meiothermus silvanus DSM 9946] 230 2e-58
ref|YP_825098.1| galactokinase [Solibacter usitatus Ellin60... 229 2e-58
ref|ZP_03990636.1| galactokinase [Oribacterium sinus F0268]... 229 2e-58
ref|ZP_01695505.1| mevalonate kinase [Bacillus coagulans 36... 229 3e-58
ref|YP_590776.1| galactokinase [Acidobacteria bacterium Ell... 229 3e-58
ref|YP_804427.1| Mevalonate kinase [Pediococcus pentosaceus... 229 5e-58
ref|ZP_03976441.1| galactokinase [Bifidobacterium longum su... 229 5e-58
ref|ZP_00120571.1| COG0153: Galactokinase [Bifidobacterium ... 228 5e-58
ref|NP_696381.1| galactokinase [Bifidobacterium longum NCC2... 228 6e-58
ref|YP_002743156.1| galactokinase [Streptococcus pneumoniae... 228 8e-58
ref|YP_001303040.1| galactokinase [Parabacteroides distason... 227 9e-58
ref|NP_142343.1| galactokinase [Pyrococcus horikoshii OT3] ... 227 1e-57
Sequences not found previously or not previously below threshold:
ref|ZP_03835936.1| galactokinase [Citrobacter youngae ATCC ... 255 4e-66
ref|YP_001453936.1| hypothetical protein CKO_02378 [Citroba... 255 6e-66
ref|YP_001438669.1| hypothetical protein ESA_02588 [Enterob... 253 2e-65
ref|XP_001138227.1| PREDICTED: galactokinase 1 [Pan troglod... 249 5e-64
ref|ZP_01868020.1| galactokinase [Vibrio shilonii AK1] >gi|... 249 5e-64
ref|YP_803749.1| galactokinase [Pediococcus pentosaceus ATC... 246 4e-63
ref|ZP_00832046.1| COG0153: Galactokinase [Yersinia interme... 245 4e-63
ref|ZP_00829490.1| COG0153: Galactokinase [Yersinia frederi... 245 5e-63
ref|NP_786690.1| galactokinase [Lactobacillus plantarum WCF... 244 1e-62
sp|Q9RGS1|GAL1_STACA Galactokinase (Galactose kinase) >gi|6... 243 2e-62
ref|NP_760656.1| galactokinase [Vibrio vulnificus CMCP6] >g... 242 3e-62
ref|NP_404747.1| galactokinase [Yersinia pestis CO92] >gi|2... 242 3e-62
ref|NP_798777.1| galactokinase [Vibrio parahaemolyticus RIM... 242 3e-62
ref|NP_935430.1| galactokinase [Vibrio vulnificus YJ016] >g... 242 6e-62
ref|ZP_01475175.1| hypothetical protein VEx2w_02002241 [Vib... 242 6e-62
ref|ZP_01813325.1| galactokinase [Vibrionales bacterium SWA... 241 8e-62
ref|ZP_00820945.1| COG0153: Galactokinase [Yersinia bercovi... 241 1e-61
ref|ZP_01162250.1| galactokinase [Photobacterium sp. SKA34]... 241 1e-61
ref|ZP_00824475.1| COG0153: Galactokinase [Yersinia mollare... 241 1e-61
ref|YP_069704.1| galactokinase [Yersinia pseudotuberculosis... 240 2e-61
ref|ZP_01234207.1| galactokinase [Vibrio angustum S14] >gi|... 239 2e-61
ref|ZP_02196242.1| galactokinase [Vibrio campbellii AND4] >... 239 3e-61
ref|YP_001446502.1| galactokinase [Vibrio harveyi ATCC BAA-... 239 4e-61
ref|YP_001007108.1| galactokinase [Yersinia enterocolitica ... 238 6e-61
ref|YP_809945.1| galactokinase [Oenococcus oeni PSU-1] >gi|... 237 9e-61
ref|ZP_01986705.1| galactokinase [Vibrio harveyi HY01] >gi|... 237 9e-61
ref|ZP_00990233.1| galactokinase [Vibrio splendidus 12B01] ... 237 1e-60
ref|ZP_01896579.1| galactokinase [Moritella sp. PE36] >gi|1... 237 1e-60
ref|ZP_01216001.1| galactokinase [Psychromonas sp. CNPT3] >... 237 1e-60
ref|ZP_02961318.1| hypothetical protein PROSTU_03341 [Provi... 236 2e-60
ref|ZP_03840717.1| galactokinase [Proteus mirabilis ATCC 29... 235 7e-60
ref|YP_206313.1| galactokinase [Vibrio fischeri ES114] >gi|... 235 7e-60
ref|YP_176714.1| galactokinase [Bacillus clausii KSM-K16] >... 234 9e-60
ref|YP_001908203.1| Galactokinase [Erwinia tasmaniensis] >g... 234 9e-60
gb|EDN13154.1| galactokinase [Vibrio cholerae RC385] 233 2e-59
ref|YP_001477523.1| galactokinase [Serratia proteamaculans ... 233 2e-59
ref|ZP_01482152.1| hypothetical protein VchoR_02001931 [Vib... 233 2e-59
ref|ZP_02137458.1| galactokinase [Vibrio fischeri MJ11] >gi... 232 6e-59
ref|YP_943380.1| galactokinase [Psychromonas ingrahamii 37]... 231 7e-59
ref|ZP_01977521.1| galactokinase [Vibrio cholerae MZO-2] >g... 231 8e-59
ref|YP_130284.1| galactokinase [Photobacterium profundum SS... 231 1e-58
ref|ZP_01956996.1| galactokinase [Vibrio cholerae MZO-3] >g... 230 2e-58
ref|YP_001488678.1| galactokinase [Bacillus pumilus SAFR-03... 230 2e-58
ref|ZP_01948739.1| galactokinase [Vibrio cholerae 1587] >gi... 229 2e-58
ref|ZP_03955949.1| galactokinase [Lactobacillus jensenii JV... 229 3e-58
ref|NP_231235.1| galactokinase [Vibrio cholerae O1 biovar e... 229 4e-58
ref|YP_001567877.1| galactokinase [Petrotoga mobilis SJ95] ... 229 5e-58
ref|ZP_01218471.1| galactokinase [Photobacterium profundum ... 229 5e-58
ref|NP_241973.1| galactokinase [Bacillus halodurans C-125] ... 229 5e-58
ref|ZP_01477813.1| hypothetical protein VchoM_02003065 [Vib... 228 6e-58
ref|NP_927924.1| galactokinase [Photorhabdus luminescens su... 228 6e-58
ref|YP_660230.1| galactokinase [Pseudoalteromonas atlantica... 228 8e-58
>gb|EDN64144.1| mevalonate kinase [Saccharomyces cerevisiae YJM789]
Length = 443
Score = 504 bits (1298), Expect = e-141, Method: Composition-based stats.
Identities = 442/443 (99%), Positives = 442/443 (99%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFN 60
MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFN
Sbjct: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFN 60
Query: 61 HKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLY 120
HKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLY
Sbjct: 61 HKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLY 120
Query: 121 MFVCLCPHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLIGSNDLEKLSENDK 180
MFVCLCPHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLIGSNDLEKLSENDK
Sbjct: 121 MFVCLCPHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLIGSNDLEKLSENDK 180
Query: 181 HIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLDDFPAIPMI 240
HIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLDDFPAIPMI
Sbjct: 181 HIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLDDFPAIPMI 240
Query: 241 LTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSKCKGTDDEA 300
LTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSKCKGTDDEA
Sbjct: 241 LTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSKCKGTDDEA 300
Query: 301 VETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGAGGGGCSLT 360
VETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGAGGGGCSLT
Sbjct: 301 VETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGAGGGGCSLT 360
Query: 361 LLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLNKDLKIKSLVFQLFEN 420
LLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLNKD KIKSLVFQLFEN
Sbjct: 361 LLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLNKDPKIKSLVFQLFEN 420
Query: 421 KTTTKQQIDDLLLPGNTNLPWTS 443
KTTTKQQIDDLLLPGNTNLPWTS
Sbjct: 421 KTTTKQQIDDLLLPGNTNLPWTS 443
>ref|NP_013935.1| Mevalonate kinase, acts in the biosynthesis of isoprenoids and
sterols, including ergosterol, from mevalonate; Erg12p
[Saccharomyces cerevisiae]
sp|P07277|KIME_YEAST Mevalonate kinase (MK) (MvK)
emb|CAA39359.1| mevalonate kinase [Saccharomyces cerevisiae]
emb|CAA29487.1| unnamed protein product [Saccharomyces cerevisiae]
emb|CAA89923.1| Rar1p [Saccharomyces cerevisiae]
Length = 443
Score = 504 bits (1297), Expect = e-141, Method: Composition-based stats.
Identities = 443/443 (100%), Positives = 443/443 (100%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFN 60
MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFN
Sbjct: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFN 60
Query: 61 HKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLY 120
HKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLY
Sbjct: 61 HKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLY 120
Query: 121 MFVCLCPHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLIGSNDLEKLSENDK 180
MFVCLCPHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLIGSNDLEKLSENDK
Sbjct: 121 MFVCLCPHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLIGSNDLEKLSENDK 180
Query: 181 HIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLDDFPAIPMI 240
HIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLDDFPAIPMI
Sbjct: 181 HIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLDDFPAIPMI 240
Query: 241 LTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSKCKGTDDEA 300
LTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSKCKGTDDEA
Sbjct: 241 LTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSKCKGTDDEA 300
Query: 301 VETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGAGGGGCSLT 360
VETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGAGGGGCSLT
Sbjct: 301 VETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGAGGGGCSLT 360
Query: 361 LLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLNKDLKIKSLVFQLFEN 420
LLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLNKDLKIKSLVFQLFEN
Sbjct: 361 LLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLNKDLKIKSLVFQLFEN 420
Query: 421 KTTTKQQIDDLLLPGNTNLPWTS 443
KTTTKQQIDDLLLPGNTNLPWTS
Sbjct: 421 KTTTKQQIDDLLLPGNTNLPWTS 443
>ref|XP_460851.1| hypothetical protein DEHA0F12188g [Debaryomyces hansenii CBS767]
emb|CAG89196.1| unnamed protein product [Debaryomyces hansenii CBS767]
Length = 433
Score = 378 bits (972), Expect = e-103, Method: Composition-based stats.
Identities = 180/439 (41%), Positives = 254/439 (57%), Gaps = 25/439 (5%)
Query: 4 PFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFNHKW 63
PFL SAPGKVII+GEHSAVY KPA+AA++S LR YLL++ + I LDFPDI +H W
Sbjct: 5 PFLVSAPGKVIIYGEHSAVYGKPAIAAALS-LRAYLLVTPCEDVNDIRLDFPDIGLSHSW 63
Query: 64 SINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLYMFV 123
+ + + + K + T+ L E+V LL +LA + HY A CFLY++
Sbjct: 64 NKENIPWEDIRKFVTFK-DEKPVVTEELVPEIVDLLSTVLADVESKLHYTACLCFLYLYA 122
Query: 124 CLCPH-AKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLIGS------NDLEKLS 176
L ++F +KSTLPIGAGLGSSA +V LA A+A LG + + + K
Sbjct: 123 NLSNKDVPGMRFIVKSTLPIGAGLGSSACTAVCLASALARLGKHVSAACHTSTEKVYKKE 182
Query: 177 ENDKHIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLDDFPA 236
+D ++ W+ +GEKC HG PSGIDNAVATYG A++F++ + + +FP
Sbjct: 183 NSDLDFIDSWSLMGEKCFHGNPSGIDNAVATYGGAVMFQR--TTIPSKPSVRTTMRNFPP 240
Query: 237 IPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSKCKGT 296
I +IL T++PRST LV V V +P+ ILDAM + +IM + S
Sbjct: 241 IKLILINTKVPRSTAALVGNVA-QVNRTYPKCAGSILDAMEHLVFEAYQIMIRPS----- 294
Query: 297 DDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGAGGGG 356
E +QL EL+ INHGLLV++GVSHP LE IK + D IGSTKLTGAGGGG
Sbjct: 295 ------FGKEEKDQLRELVNINHGLLVALGVSHPALEKIKIIGDTHGIGSTKLTGAGGGG 348
Query: 357 CSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLNKDLKIKSLVFQ 416
C+++L+ D+ +E I K+ +++ YETFET LGG G LS ++++KD + +
Sbjct: 349 CAISLVHDDVEEEVIQKAIKEFENE-GYETFETSLGGKGVGSLSLEDVDKDKRDTVFSAE 407
Query: 417 LFENKTTTKQQIDDLLLPG 435
+F + + +++ L
Sbjct: 408 VFSSYKD-RDEVEKALKSD 425
>ref|XP_001644409.1| hypothetical protein Kpol_1064p33 [Vanderwaltozyma polyspora DSM
70294]
gb|EDO16551.1| hypothetical protein Kpol_1064p33 [Vanderwaltozyma polyspora DSM
70294]
Length = 421
Score = 372 bits (954), Expect = e-101, Method: Composition-based stats.
Identities = 244/441 (55%), Positives = 325/441 (73%), Gaps = 23/441 (5%)
Query: 2 SLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFNH 61
+PF+TSAPGKVIIFGEHSAVYN+PAVAASVS+LRT+LL+ + + DT+ L+FPDI F+H
Sbjct: 1 MIPFITSAPGKVIIFGEHSAVYNEPAVAASVSSLRTFLLVEDGAHRDTVALNFPDIKFHH 60
Query: 62 KWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDP-LLAQLSESFHYHAAFCFLY 120
+W ++ + + + L KA++ T+ LSQ LV+LL+ LL L ES H+HAAFCF+Y
Sbjct: 61 EWRHSEIHQVIKLAEADGLLTKARKDTNNLSQPLVTLLEEKLLGSLKESLHFHAAFCFIY 120
Query: 121 MFVCLCPHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLIGSNDLEKLSENDK 180
++VCLCP+ ++KFSLKSTLPIGAGLGSSASISV+L+LAMA LGG I S + L+ DK
Sbjct: 121 LYVCLCPNVNHVKFSLKSTLPIGAGLGSSASISVALSLAMAKLGGHIKSTE--SLTSADK 178
Query: 181 HIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLDDFPAIPMI 240
+N W+FIGEKCIHGTPSGIDNAVATYGNA+LF+K+ + T NF+F+D+FP IPMI
Sbjct: 179 KYINSWSFIGEKCIHGTPSGIDNAVATYGNAVLFKKEDNGST----NFQFIDNFPKIPMI 234
Query: 241 LTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSKCKGTDDEA 300
LTYTRIPRSTK LV+ VR LV EK+P + KPIL +MG A G +I+
Sbjct: 235 LTYTRIPRSTKVLVSNVRELV-EKYPSIFKPILQSMGHLANDGADILR------------ 281
Query: 301 VETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGAGGGGCSLT 360
N++ Y LLEL+R+NHGLLVS+GVSHPGLE+IK+LSD + +GSTKLTGAGGGGCSLT
Sbjct: 282 -NLNDKNYNDLLELVRVNHGLLVSLGVSHPGLEIIKSLSDTMDLGSTKLTGAGGGGCSLT 340
Query: 361 LLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLNKDLKIKSLVFQLFEN 420
+L++D+TQ+QI +FK L++ +Y T++TDLGG GC +S ++ + I ++ + E
Sbjct: 341 ILKKDVTQDQIKTFKSILKEKHNYGTYDTDLGGMGCSFVSLDSIPEKDAI--VIKAILEA 398
Query: 421 KTTTKQQIDDLLLPGNTNLPW 441
+ + ++Q+ L + L W
Sbjct: 399 RESPREQLTKFLFSDESVLTW 419
>ref|XP_001229023.1| hypothetical protein CHGG_02507 [Chaetomium globosum CBS 148.51]
gb|EAQ90572.1| hypothetical protein CHGG_02507 [Chaetomium globosum CBS 148.51]
Length = 532
Score = 371 bits (952), Expect = e-101, Method: Composition-based stats.
Identities = 157/410 (38%), Positives = 237/410 (57%), Gaps = 26/410 (6%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFN 60
M F+ SAPGKVI+FGEHS V+ K A+AA++S L+ + S + T+ L FPDI F+
Sbjct: 82 MMPAFMVSAPGKVIVFGEHSVVHGKAAIAAAISLRSYLLVTTLSKSKRTVTLKFPDIDFD 141
Query: 61 HKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLS-------ESFHYH 113
H W+I++ T Q + +K L ELV+ + P LA +S H +
Sbjct: 142 HCWNIDELPWATFQQPSKKKYY--YSLVTELDPELVAAIQPFLANVSPDKPAGIRKVHQN 199
Query: 114 AAFCFLYMFVCLCPHA-KNIKFSLKSTLPIGAGLGSSASISVSLALA-MAYLGGLIGSND 171
+A FLYMF+ L + +++L+ST+PIGAGLGSSA+I+V ++ A + L L G +
Sbjct: 200 SAGSFLYMFLSLGSQSFPGCQYTLRSTIPIGAGLGSSATIAVCMSAALLLQLRTLAGPHP 259
Query: 172 LEKLSENDK--HIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFK 229
+ E +N+WA++ E IHG PSG+DN VAT G A++F++ + + +
Sbjct: 260 DQPADEARMQIERINRWAYVYEMFIHGNPSGVDNTVATQGKAVVFQRTDYG---KPPSVR 316
Query: 230 FLDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTK 289
L DFP +P++L TR+P+ST VA+V L P ++ ILDAM + A E++T+
Sbjct: 317 PLWDFPELPLLLVDTRVPKSTAHEVAKVGKL-KNTHPVLVGSILDAMDKVADASAEVLTE 375
Query: 290 LSKCKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKL 349
+ ++ EL+ +NHGLLVS+GVSHP LE ++ L D IG TKL
Sbjct: 376 EG--------FDTQSEASLARVGELMTVNHGLLVSLGVSHPRLERVRELVDHEGIGWTKL 427
Query: 350 TGAGGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLL 399
TGAGGGGC +TLL+ + ++++ + +L ++ +E FET LGG G +L
Sbjct: 428 TGAGGGGCCITLLKPGVERKKLRKLQAQLDEE-GFEKFETTLGGDGVGVL 476
>ref|XP_001593159.1| hypothetical protein SS1G_06081 [Sclerotinia sclerotiorum 1980]
gb|EDO03600.1| hypothetical protein SS1G_06081 [Sclerotinia sclerotiorum 1980]
Length = 473
Score = 370 bits (951), Expect = e-101, Method: Composition-based stats.
Identities = 170/411 (41%), Positives = 242/411 (58%), Gaps = 30/411 (7%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISE-SSAPDTIELDFPDISF 59
M PF+ SAPGKVI+FGEH+ V+ KPA+AA++S LR+YLL++ S + TI L FPDI+
Sbjct: 26 MMPPFMVSAPGKVIVFGEHAVVHGKPAIAAAIS-LRSYLLVTALSKSKRTISLRFPDINL 84
Query: 60 NHKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLS-------ESFHY 112
+H W+I+D T + +K Q L ELV+ + P L +S H
Sbjct: 85 SHTWNIDDLPWSTFSHPSKKKYYYDQ--VTSLDPELVAAMKPHLENISPDESPSIRKIHQ 142
Query: 113 HAAFCFLYMFVCLCPHA-KNIKFSLKSTLPIGAGLGSSASISVSLALA-MAYLGGLIGSN 170
+A FLY+F+ L + ++L+ST+PIGAGLGSSASISV L+ A + + L G +
Sbjct: 143 SSASSFLYIFLSLGSQSFPGCLYTLRSTIPIGAGLGSSASISVCLSSALLLQIRTLSGPH 202
Query: 171 DLEKLSENDKHI--VNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNF 228
+ +E + +N+WAF+GE CIHG PSG+DN V+T G A++++K
Sbjct: 203 PDQPSNEASLQLERINRWAFVGEMCIHGNPSGVDNTVSTQGKAVIYQKFPEG-----PTV 257
Query: 229 KFLDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMT 288
K L DFP +P++L T+ +ST VA+V L+ EK P ++ ILDA+ +++
Sbjct: 258 KPLRDFPELPLLLVDTQQAKSTAHEVAKVG-LLKEKHPAIVDSILDAIDMVGQSAAAMIS 316
Query: 289 KLSKCKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTK 348
+ N E E L +L+ INHGLLVS+GVSHP LE I+ L D IG TK
Sbjct: 317 DPN--------YDSENIECVESLGKLMTINHGLLVSLGVSHPRLERIRELVDHEGIGWTK 368
Query: 349 LTGAGGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLL 399
LTGAGGGGCS+TLL+ D T E++ + L+++ Y+ FET LG G +L
Sbjct: 369 LTGAGGGGCSITLLKPDTTPERMARLEATLENE-GYKKFETTLGCDGVGVL 418
>ref|XP_001911734.1| unnamed protein product [Podospora anserina]
emb|CAP73562.1| unnamed protein product [Podospora anserina]
Length = 528
Score = 366 bits (939), Expect = 2e-99, Method: Composition-based stats.
Identities = 161/411 (39%), Positives = 245/411 (59%), Gaps = 28/411 (6%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISE-SSAPDTIELDFPDISF 59
M F+ SAPGKVI+FGEH+ V+ K A+AAS++ LR+YLL++ S + T+ L FPDI F
Sbjct: 73 MMPSFMVSAPGKVIVFGEHAVVHGKAAIAASIA-LRSYLLVTSLSKSRKTVTLKFPDIDF 131
Query: 60 NHKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLS-------ESFHY 112
+H W I++ Q + +K + QELV+ + P LA +S H
Sbjct: 132 DHSWRIDELPWAIFQQPSKKKYY--YSLVTEIDQELVAAIQPYLADVSPDKPADVRKVHQ 189
Query: 113 HAAFCFLYMFVCLCPHA-KNIKFSLKSTLPIGAGLGSSASISVSLALAMA-YLGGLIGSN 170
++A FLYMF+ L + +++L+ST+PIGAGLGSSA+I+V L+ A+ L L G +
Sbjct: 190 NSAGSFLYMFLSLGSQSFPACQYTLRSTIPIGAGLGSSATIAVCLSAALLLQLRTLSGPH 249
Query: 171 DLEKLSENDK--HIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNF 228
+ E +N+WA++ E IHG PSG+DN V+T G A++F++ ++ +
Sbjct: 250 PDQPPEEARMQIERINRWAYVYEMFIHGNPSGVDNTVSTQGKAVMFQRTDYSKAPD---V 306
Query: 229 KFLDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMT 288
K L DFP +P++L TR P+ST VA+V L + P+++ ILDA+ + E++
Sbjct: 307 KPLWDFPELPLLLVDTRTPKSTAHEVAKVGRL-KDTHPKLVGSILDAIDKVTQTSAELIA 365
Query: 289 KLSKCKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTK 348
+ D+ + ++ EL+ INHGLLVS+GVSHP LE ++ L D IG TK
Sbjct: 366 E--------DDFSTEKEDSLRRVGELMNINHGLLVSLGVSHPRLERVRELVDHQGIGWTK 417
Query: 349 LTGAGGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLL 399
LTGAGGGGCS+TLL+ + +E++ +++L ++ Y+ FET LGG G +L
Sbjct: 418 LTGAGGGGCSITLLKPGVPREKLARLEEQLDEE-GYQRFETTLGGDGVGVL 467
>ref|XP_386088.1| hypothetical protein FG05912.1 [Gibberella zeae PH-1]
Length = 508
Score = 365 bits (936), Expect = 5e-99, Method: Composition-based stats.
Identities = 165/411 (40%), Positives = 240/411 (58%), Gaps = 28/411 (6%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISE-SSAPDTIELDFPDISF 59
M+ PF+ SAPGKVI+FGEHS V+ K A+AA++S LR+YL ++ S + T+ L F DI
Sbjct: 57 MAPPFMVSAPGKVIVFGEHSVVHGKAAIAAAIS-LRSYLHVTTLSKSKRTVSLRFADIGL 115
Query: 60 NHKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLS-------ESFHY 112
H W+I D Q + +K L +LV+ + P + +S H+
Sbjct: 116 VHTWNIEDLPWEAFQQPSKKKSY--YSLVTELDPDLVAAIQPHIEVVSPNHPEEIRRVHH 173
Query: 113 HAAFCFLYMFVCLCPHA-KNIKFSLKSTLPIGAGLGSSASISVSLALAMA-YLGGLIGSN 170
+ FLY+F+ L + ++L+ST+PIGAGLGSSAS+SV LA A+ L L G +
Sbjct: 174 SSVSAFLYLFLSLGSPSFPPCLYTLRSTIPIGAGLGSSASVSVCLASALLLQLRTLSGPH 233
Query: 171 DLEKLSENDK--HIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNF 228
+ E +N+WAF+ E CIHG PSG+DN VAT G A++F++ ++ N
Sbjct: 234 PDQPADEARLQVERINRWAFVSEMCIHGNPSGVDNTVATQGKAVVFQRTDYSKP---PNV 290
Query: 229 KFLDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMT 288
+ L DFP +P++L TR +ST VA+V L + P+++ ILDAM + E++
Sbjct: 291 RPLWDFPELPLLLVDTRQAKSTAHEVAKVAKL-KQTHPKLVNSILDAMDKVTDAASELIE 349
Query: 289 KLSKCKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTK 348
+ S G+ E ++ EL+ INHGLLVS+GVSHP LE ++ L D IG TK
Sbjct: 350 ETSFDNGSV--------EDLSKVGELMTINHGLLVSLGVSHPRLERVRELVDHEGIGWTK 401
Query: 349 LTGAGGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLL 399
LTGAGGGGCS+TLLR D+ E++ +++L+ + +Y FET LGG G +L
Sbjct: 402 LTGAGGGGCSITLLRPDVPAEKLQKLEERLETE-NYAKFETTLGGDGIGVL 451
>ref|XP_001382664.2| mevalonate kinase [Pichia stipitis CBS 6054]
gb|ABN64635.2| mevalonate kinase [Pichia stipitis CBS 6054]
Length = 432
Score = 363 bits (931), Expect = 2e-98, Method: Composition-based stats.
Identities = 186/439 (42%), Positives = 267/439 (60%), Gaps = 25/439 (5%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFN 60
MS PF SAPGKVIIFGEHSAVY KPA+AA++S LR YLL++ S PDTI L FPDI+
Sbjct: 1 MSTPFFVSAPGKVIIFGEHSAVYGKPAIAAALS-LRAYLLVTPSQDPDTINLSFPDINLT 59
Query: 61 HKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLY 120
H W+ ND + + + + Q ++ L E+V L +LA L+ S HY A CFLY
Sbjct: 60 HSWNKNDIPWDSIVKHIN-LVDNLPQTSEELVPEIVDQLGSVLADLNSSLHYTACLCFLY 118
Query: 121 MFVCLCPH-AKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLIGS------NDLE 173
++ LC + F ++STLPIGAGLGSSAS +V LA A+A LG + S + +
Sbjct: 119 LYTHLCNQELAGMSFCIRSTLPIGAGLGSSASTAVCLASALAILGNRVTSASFLQTDKIL 178
Query: 174 KLSENDKHIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLDD 233
K ND ++ W+ +GEKC HG PSGIDNAVAT+G A++F++ ++ + + +
Sbjct: 179 KKENNDLDFIDSWSLMGEKCFHGNPSGIDNAVATHGGAVMFQRMNNPAQPSVRT--SMRN 236
Query: 234 FPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSKC 293
FPAI ++LT T++PRST DLV V L E +P+ IL+AM + +IM +
Sbjct: 237 FPAIKLLLTNTKVPRSTADLVGGVGKLNVE-YPKTSNSILEAMEHLSNTAYQIMVRP--- 292
Query: 294 KGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGAG 353
E ++L EL+ INHGLLV++GVSHP LE +K ++D ++GSTKLTGAG
Sbjct: 293 --------FFGAEERKKLRELVNINHGLLVALGVSHPSLEKVKIITDTSKLGSTKLTGAG 344
Query: 354 GGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLNKDLKIKSL 413
GGGC++TL+ D+++ I +L+ + YE FET LGG G LS +++ ++L+
Sbjct: 345 GGGCAITLVDEDVSEADIAQGIAELEKE-GYECFETSLGGKGVGSLSFEDVPQELRSTVF 403
Query: 414 VFQLFENKTTTKQQIDDLL 432
+ F + + +I+ +L
Sbjct: 404 SPEKFCAYSD-RIEIEKVL 421
>ref|XP_723495.1| mevalonate kinase [Candida albicans SC5314]
ref|XP_723305.1| mevalonate kinase [Candida albicans SC5314]
gb|EAL04601.1| hypothetical protein CaO19.12272 [Candida albicans SC5314]
gb|EAL04797.1| hypothetical protein CaO19.4809 [Candida albicans SC5314]
Length = 431
Score = 362 bits (928), Expect = 4e-98, Method: Composition-based stats.
Identities = 181/436 (41%), Positives = 251/436 (57%), Gaps = 24/436 (5%)
Query: 1 MS-LPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISF 59
MS LPF+ APGKVIIFGEH+AVY KPA+AA++S LR YLL+S SS +TI L FPDI
Sbjct: 1 MSQLPFIVGAPGKVIIFGEHAAVYGKPAIAAALS-LRCYLLVSPSSDSNTIRLQFPDIKL 59
Query: 60 NHKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFL 119
+H W+I D + A Q L E+V L L HY+A FCFL
Sbjct: 60 DHSWNIKDLPWEEIKPYLTYDSANKPQIPSELVPEIVDKLSSFLNGFDNKMHYYACFCFL 119
Query: 120 YMFVCLCP-HAKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLIGSNDLEKLSEN 178
Y+ + LC + F ++STLPIGAGLGSSAS SV L+ A+A +GG I L + +
Sbjct: 120 YLLMNLCDSKVSGMNFIVRSTLPIGAGLGSSASTSVCLSSALALMGGWINKPSLHENDKL 179
Query: 179 D------KHIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLD 232
D +++W+ IGEKC HG PSGIDNAVAT+G A++F++ S + +
Sbjct: 180 DTADIPDLEFIDKWSLIGEKCFHGNPSGIDNAVATFGGAVMFQRTSTPEQPSIRT--NMR 237
Query: 233 DFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSK 292
+FPAI ++LT T++P+ST DLVA V L E F + IL A+ + + ++M
Sbjct: 238 NFPAIKLLLTNTKVPKSTADLVAGVGRLNAE-FNSISTSILTAIEHLSQEAYKVMMNP-- 294
Query: 293 CKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGA 352
E L +L+ INHGLLV++GVSHP LE +K + D RIG+TKLTGA
Sbjct: 295 ---------MFGKEETNVLRKLVNINHGLLVALGVSHPALETVKIIGDKHRIGATKLTGA 345
Query: 353 GGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLNKDLKIKS 412
GGGGC++TL+ D+ + I + K+ +D YE+FET LGG G +L ++L+ K
Sbjct: 346 GGGGCAITLVNDDVEESVIHNAIKEFEDS-GYESFETSLGGKGVGILFHEDLDDATKFSE 404
Query: 413 LVFQLFENKTTTKQQI 428
+ ++ + +
Sbjct: 405 SQICNYVDRAAIEDSL 420
>ref|XP_001559870.1| hypothetical protein BC1G_01429 [Botryotinia fuckeliana B05.10]
gb|EDN27159.1| hypothetical protein BC1G_01429 [Botryotinia fuckeliana B05.10]
Length = 498
Score = 361 bits (927), Expect = 5e-98, Method: Composition-based stats.
Identities = 163/411 (39%), Positives = 241/411 (58%), Gaps = 30/411 (7%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISE-SSAPDTIELDFPDISF 59
M PF+ SAPGKVI+FGEH+ V+ KPA+AA++S LR+YLL++ S + TI L FPDI+
Sbjct: 50 MMPPFMVSAPGKVIVFGEHAVVHGKPAIAAAIS-LRSYLLVTSLSKSKRTISLRFPDINL 108
Query: 60 NHKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLS-------ESFHY 112
+H W+I+D T + +K L ELV+ + P L +S H
Sbjct: 109 SHTWNIDDLPWSTFSHPSKKKHY--YDEVTSLDPELVAAMKPHLENISPDESPAIRKIHQ 166
Query: 113 HAAFCFLYMFVCLCPHA-KNIKFSLKSTLPIGAGLGSSASISVSLALA-MAYLGGLIGSN 170
+A FLY+F+ L + ++L+ST+PIGAGLGSSASISV L+ A + + L G +
Sbjct: 167 SSASSFLYIFLSLGSQSFPGCLYTLRSTIPIGAGLGSSASISVCLSSALLLQIRTLSGPH 226
Query: 171 DLEKLSENDKHI--VNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNF 228
+ +E + +N+WAF+GE CIHG PSG+DN V+T G A++++K + +
Sbjct: 227 PDQPSNEASLQLERINRWAFVGEMCIHGNPSGVDNTVSTQGKAVIYQK-----SPDGPTV 281
Query: 229 KFLDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMT 288
K L +FP +P++L T+ +ST VA+V L+ +K P ++ IL+A+
Sbjct: 282 KPLRNFPELPLLLVDTQQAKSTAHEVAKV-DLLKQKHPAIVDSILNAIDMVGQSAA---- 336
Query: 289 KLSKCKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTK 348
+D E + + E L +L+ +NHGLLVS+GVSHP LE I+ L D IG TK
Sbjct: 337 ----VMISDPEYDSEDLKCVEDLGKLMTVNHGLLVSLGVSHPRLERIRELVDHEGIGWTK 392
Query: 349 LTGAGGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLL 399
LTGAGGGGCS+TLL+ T +++ ++ L+ + Y+ FET LG G +L
Sbjct: 393 LTGAGGGGCSITLLKPGTTHDRMTRLEETLETE-GYKKFETTLGCDGVGVL 442
>ref|XP_961360.1| hypothetical protein NCU03633 [Neurospora crassa OR74A]
emb|CAC28692.1| related to MEVALONATE KINASE [Neurospora crassa]
gb|EAA32124.1| hypothetical protein NCU03633 [Neurospora crassa OR74A]
Length = 528
Score = 361 bits (927), Expect = 7e-98, Method: Composition-based stats.
Identities = 161/411 (39%), Positives = 240/411 (58%), Gaps = 28/411 (6%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLI-SESSAPDTIELDFPDISF 59
M F+ SAPGKVI+FGEH+ V+ K A+AA++S LR+YLL+ + S + T+ L FPDI F
Sbjct: 76 MMPTFMVSAPGKVIVFGEHAVVHGKAAIAAAIS-LRSYLLVNTLSKSKRTVTLKFPDIDF 134
Query: 60 NHKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLS-------ESFHY 112
NH W+I++ Q +K + QELV + P LA +S H
Sbjct: 135 NHSWNIDELPWKIFQQPGKKKYY--YSLVTEIDQELVDAVQPFLADVSIDKPADIRKVHQ 192
Query: 113 HAAFCFLYMFVCLCPHA-KNIKFSLKSTLPIGAGLGSSASISVSLALA-MAYLGGLIGSN 170
++A FLYMF+ L + +++L+ST+PIGAGLGSSA+I+V L+ A + L L G +
Sbjct: 193 NSAGSFLYMFLSLGSQSFPGCQYTLRSTIPIGAGLGSSATIAVCLSAALLLQLRTLSGPH 252
Query: 171 DLEKLSENDK--HIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNF 228
+ E +N+WAF+ E IHG PSG+DN V+T G A++F++ +N +
Sbjct: 253 PDQPPEEARLQIERINRWAFVYEMFIHGNPSGVDNTVSTQGKAVVFQRTDYNQP---PSV 309
Query: 229 KFLDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMT 288
+ L DFP +P++L TR +ST VA+V L K P+++ IL A+ + +++
Sbjct: 310 RPLWDFPKLPLLLVDTRTAKSTAHEVAKVATLKK-KHPQLVGTILTAIDQVTQSSAQLIE 368
Query: 289 KLSKCKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTK 348
+ + E ++ E++ INHGLLVS+GVSHP LE ++ L D IG TK
Sbjct: 369 EQGFNT--------EDEESLSKVGEMMTINHGLLVSLGVSHPRLERVRELVDHEGIGWTK 420
Query: 349 LTGAGGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLL 399
LTGAGGGGCS+TLLR + +E++D +++L ++ Y FET LG G +L
Sbjct: 421 LTGAGGGGCSITLLRPGVPREKLDKLEQRLDEE-GYSKFETTLGSDGVGVL 470
>ref|XP_001527900.1| hypothetical protein LELG_00420 [Lodderomyces elongisporus NRRL
YB-4239]
gb|EDK42242.1| hypothetical protein LELG_00420 [Lodderomyces elongisporus NRRL
YB-4239]
Length = 439
Score = 358 bits (918), Expect = 7e-97, Method: Composition-based stats.
Identities = 169/416 (40%), Positives = 243/416 (58%), Gaps = 24/416 (5%)
Query: 2 SLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESS-APDTIELDFPDISFN 60
SL F+ SAPGKVIIFGEH+AVY KPA+AA++S LR +LL++ S+ + + L FPDI +
Sbjct: 8 SLKFVVSAPGKVIIFGEHAAVYGKPAIAAALS-LRCFLLVTPSTGDSNMVRLKFPDIGLD 66
Query: 61 HKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLY 120
H W I+ T Q L E+V L PLL L ++ HY A FCFLY
Sbjct: 67 HSWDISSIPWETIKAKVKADSNGKPQPPAELDPEIVDSLSPLLRNLDDNVHYIACFCFLY 126
Query: 121 MFVCLCPH-AKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLIGSNDLEKLSE-- 177
++ LC + F ++STLPIGAGLGSSAS +V L+ A++ LG I L
Sbjct: 127 LYTNLCSQDLQGYTFVVRSTLPIGAGLGSSASTAVCLSAALSKLGNWIKDPKLSNHDHVL 186
Query: 178 ----NDKHIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLDD 233
+ ++ W+ IGEKC HG PSGIDNAVAT+G A+ +++ + ++ + D
Sbjct: 187 ESEIPELDFIDNWSLIGEKCFHGNPSGIDNAVATHGGAVKYQR--ILNSTKSSLRSSIRD 244
Query: 234 FPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSKC 293
FP I ++LT T++P+ST LVA V L E FP++ PIL+A+ + Q E+M
Sbjct: 245 FPPIKLLLTNTKVPKSTAKLVAGVGELTKE-FPDITNPILNAVEFISEQAYEVMH----- 298
Query: 294 KGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGAG 353
+ + L +L+ +NHGLLV++GVSHP LE +K +SD +G+TKLTGAG
Sbjct: 299 ------LPQFGKQETATLRKLVNMNHGLLVALGVSHPALETVKIISDKYNLGATKLTGAG 352
Query: 354 GGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLNKDLK 409
GGGC++TL+ I + I + K+ +++ +E+FET LGG G +L + + K
Sbjct: 353 GGGCAITLVDESIDKSVIHNAMKEYENE-GFESFETSLGGKGVGMLFEDDCQESEK 407
>ref|XP_001214601.1| conserved hypothetical protein [Aspergillus terreus NIH2624]
gb|EAU34492.1| conserved hypothetical protein [Aspergillus terreus NIH2624]
Length = 541
Score = 356 bits (914), Expect = 2e-96, Method: Composition-based stats.
Identities = 157/410 (38%), Positives = 227/410 (55%), Gaps = 26/410 (6%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFN 60
++ F+ SAPGKVI+FGEH+ V+ K A+AA++S L+ + + + T+ L+F DI
Sbjct: 92 LAPTFMVSAPGKVIVFGEHAVVHGKAAMAAAISLRSYLLVTTLTKSQRTVTLNFRDIGLA 151
Query: 61 HKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLS-------ESFHYH 113
H W+I+D Q +K L ELV + P + Q+S H
Sbjct: 152 HTWNIDDLPWDVFHQPAKKKYY--YDLVTSLDPELVDAIQPYVDQVSPDLPEDQRKIHRR 209
Query: 114 AAFCFLYMFVCLC-PHAKNIKFSLKSTLPIGAGLGSSASISVSLALA-MAYLGGLIGSND 171
+A FLY+ + L P ++L+ST+PIGAGLGSSAS+ V L+ A + + L G +
Sbjct: 210 SASAFLYLLLSLGSPQHPGAIYTLRSTIPIGAGLGSSASVCVCLSAALLLQIRTLAGPHP 269
Query: 172 LEKLSENDK--HIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFK 229
+ E + +N+WAF+GE C HG PSG+DN V+ G A++F + ++ + +
Sbjct: 270 DQPPDEAEVQIERINRWAFVGEMCTHGNPSGVDNTVSAGGKAVIFRRTDYS---KPPSVR 326
Query: 230 FLDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTK 289
L FP +P++L TR PRST VA+V L E+ P V + ILDA+ + L E++
Sbjct: 327 SLPTFPELPLLLVDTRQPRSTAVEVAKVGKL-KEEHPVVTESILDAIDKLTLSAEELLDG 385
Query: 290 LSKCKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKL 349
K T E+ E+L L+RINHG LVS+GVSHP LE I+ L D IG TKL
Sbjct: 386 CEKTGVT--------EEVLERLGTLVRINHGFLVSLGVSHPRLERIRELVDFANIGWTKL 437
Query: 350 TGAGGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLL 399
TGAGGGGC++TLLR D + + + KL + +ET LGG G +L
Sbjct: 438 TGAGGGGCAITLLRPDADKNAVRDLEAKL-AAEGFAKYETTLGGDGIGVL 486
>ref|NP_985191.1| AER335Wp [Ashbya gossypii ATCC 10895]
gb|AAS53015.1| AER335Wp [Ashbya gossypii ATCC 10895]
Length = 428
Score = 356 bits (913), Expect = 3e-96, Method: Composition-based stats.
Identities = 211/440 (47%), Positives = 290/440 (65%), Gaps = 29/440 (6%)
Query: 3 LPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFNHK 62
LPF+TSAPGKVIIFGEHSAVYNKPA+AASVS+LRTYL + + D + ++FPDI F +
Sbjct: 14 LPFITSAPGKVIIFGEHSAVYNKPAIAASVSSLRTYLFVEADAESDAVRMEFPDIGFQYS 73
Query: 63 WSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLYMF 122
W A+ + V ++ L E+++ +D LL L + HAA CFLY++
Sbjct: 74 WKHEALTAVPREAVVRAFCSR------ELDAEVLAHVDRLLMGLEGALARHAALCFLYIY 127
Query: 123 VCLCPHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLIGSNDLEKLSENDKHI 182
CLC + ++F++KSTLPIGAGLGSSASI+V LALAM LGG + L++ +
Sbjct: 128 TCLCREVQGVRFTVKSTLPIGAGLGSSASIAVCLALAMGRLGGHVQCESGA-LTKEQQDF 186
Query: 183 VNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLDDFPAIPMILT 242
VN+WA +GE+CIHGTPSGIDNAVATYG+A+LF++ T F L DFP +PMILT
Sbjct: 187 VNRWALVGEQCIHGTPSGIDNAVATYGDAVLFQRQPDGST----KFDHLSDFPQMPMILT 242
Query: 243 YTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSKCKGTDDEAVE 302
T++P+STK LVA V LV E+ P + PIL+ M + Q E++ ++
Sbjct: 243 NTKVPKSTKVLVANVGKLV-EQEPLITAPILNTMAQVVTQAHELL-----------PLLQ 290
Query: 303 TNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGAGGGGCSLTLL 362
++ +Y +LL+L+RINHGLLV++GVSHP LE ++ L D L IG+TKLTGAGGGGC+LTLL
Sbjct: 291 GDDTVYTRLLQLVRINHGLLVALGVSHPSLEHVRALCDTLGIGATKLTGAGGGGCALTLL 350
Query: 363 RRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLNKDL-KIKSLVFQLFENK 421
+RD+ E ++ F+K L D YE+F T LGG GCCL +++ + L +IK+L +
Sbjct: 351 KRDVEDELVEQFRKTLLDKHGYESFTTGLGGVGCCLATSQTIRPHLDRIKTLF-----QE 405
Query: 422 TTTKQQIDDLLLPGNTNLPW 441
T +QQ+ + LLPG + + W
Sbjct: 406 DTPQQQLAEALLPGASPIDW 425
>ref|XP_661473.1| hypothetical protein AN3869.2 [Aspergillus nidulans FGSC A4]
gb|EAA59134.1| hypothetical protein AN3869.2 [Aspergillus nidulans FGSC A4]
Length = 735
Score = 355 bits (912), Expect = 3e-96, Method: Composition-based stats.
Identities = 153/410 (37%), Positives = 229/410 (55%), Gaps = 26/410 (6%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFN 60
++ F+ SAPGKVI++GEH+ V+ K A+AA++S L+ + S + TI L+F D + N
Sbjct: 287 LAPAFMVSAPGKVIVYGEHAVVHGKAAMAAAISLRSYLLVTTLSKSQRTITLNFRDTNLN 346
Query: 61 HKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLS-------ESFHYH 113
H W I+ + +K L QEL + P + +S H
Sbjct: 347 HTWDIDQLPWDLFHHPSKKKYY--YDLVTTLDQELYDAIQPHVEDISPDAPEEMRKIHKR 404
Query: 114 AAFCFLYMFVCLC-PHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMA-YLGGLIGSND 171
+A FLY+F+ L P + ++L+ST+PIGAGLGSSAS+ V ++ A+ + L G +
Sbjct: 405 SASAFLYLFLSLGSPQSAGAIYTLRSTIPIGAGLGSSASVCVCMSAALLVQIRTLAGPHP 464
Query: 172 LEKLSENDK--HIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFK 229
+ E + +N+WAF+GE CIHG PSG+DN V+ G A++F + ++ +
Sbjct: 465 DQPPDEAEVQIERINRWAFVGEMCIHGNPSGVDNTVSAGGKAVIFRRGDYS---KPPSVT 521
Query: 230 FLDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTK 289
L FP +P++L TR RST VA+V L E +P V + ILDA+ +++ +
Sbjct: 522 SLPTFPELPLLLVDTRQGRSTAVEVAKVGALRKE-WPVVTESILDAIDNVTASAEKVIRE 580
Query: 290 LSKCKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKL 349
+ + + +QL LIRINHG LVS+GVSHP LE I+ L D IG TKL
Sbjct: 581 PNP--------EGLSEKTLQQLGTLIRINHGFLVSLGVSHPRLERIRELVDYADIGWTKL 632
Query: 350 TGAGGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLL 399
TGAGGGGC++TLLR D+ + + K +LQD+ ++ +ET LGG G +L
Sbjct: 633 TGAGGGGCAITLLRPDLNDDSLRQLKSQLQDE-NFGIYETTLGGDGVGVL 681
>ref|XP_752047.1| mevalonate kinase [Aspergillus fumigatus Af293]
gb|EAL90009.1| mevalonate kinase [Aspergillus fumigatus Af293]
Length = 538
Score = 355 bits (912), Expect = 3e-96, Method: Composition-based stats.
Identities = 153/410 (37%), Positives = 226/410 (55%), Gaps = 26/410 (6%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFN 60
M+ F+ SAPGKVI++GEH+ V+ K A+AA++S L+ + S + TI ++F DI +
Sbjct: 88 MAPAFMVSAPGKVIVYGEHAVVHGKAAMAAAISLRSYLLVTTLSKSQRTITMNFRDIGLD 147
Query: 61 HKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLS-------ESFHYH 113
H W+I++ + +K L ELV+ + P +S H
Sbjct: 148 HTWNIDELPWDVFHHPSKKKFY--YDLVTSLDPELVAAIQPHADAVSPDKPEDVRKIHRR 205
Query: 114 AAFCFLYMFVCLC-PHAKNIKFSLKSTLPIGAGLGSSASISVSLALA-MAYLGGLIGSND 171
+A FLY+F+ L ++L+ST+PIGAGLGSSAS+ V L+ A + + L G +
Sbjct: 206 SASAFLYLFLSLGSSQNPGAIYTLRSTIPIGAGLGSSASVCVCLSAALLLQIRTLAGPHP 265
Query: 172 LEKLSENDK--HIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFK 229
+ E + +N+WAF+GE C HG PSG+DN V+ G A++F ++ ++
Sbjct: 266 DQPPDEAEVQIERINRWAFVGEMCTHGNPSGVDNTVSAGGKAVVFRREDYS---KPPTVT 322
Query: 230 FLDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTK 289
L +FP +P++L TR RST VA+V L E +P V IL+A+ + L + + +
Sbjct: 323 PLLNFPELPLLLVDTRQSRSTAVEVAKVGKLKDE-YPVVTDSILEAIDQVTLAAQQKIQE 381
Query: 290 LSKCKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKL 349
+S + E L LIRINHG LVS+GVSHP LE I+ L D IG TKL
Sbjct: 382 ISTNGI--------SYRTLEDLGTLIRINHGFLVSLGVSHPRLERIRELVDYADIGWTKL 433
Query: 350 TGAGGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLL 399
TGAGGGGC++TLLR DI +E + ++KL + +ET LGG G +L
Sbjct: 434 TGAGGGGCAITLLRPDIKEEAVRELEEKL-SAEGFVKYETTLGGDGIGVL 482
>ref|XP_001271672.1| mevalonate kinase [Aspergillus clavatus NRRL 1]
gb|EAW10246.1| mevalonate kinase [Aspergillus clavatus NRRL 1]
Length = 536
Score = 355 bits (912), Expect = 4e-96, Method: Composition-based stats.
Identities = 153/410 (37%), Positives = 226/410 (55%), Gaps = 26/410 (6%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFN 60
M+ F+ SAPGKVI++GEH+ V+ K A+AA++S L+ + S + T+ ++F DI +
Sbjct: 85 MAPAFMVSAPGKVIVYGEHAVVHGKAAMAAAISLRSYLLVTTLSKSQRTVTMNFRDIGLD 144
Query: 61 HKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLS-------ESFHYH 113
H W+I+D + +K L ELV + P + +S H
Sbjct: 145 HTWNIDDLPWDVFHHPSKKKFY--YNLVTSLDPELVDAIQPHVDAVSPDKPEDVRKIHRR 202
Query: 114 AAFCFLYMFVCLC-PHAKNIKFSLKSTLPIGAGLGSSASISVSLALA-MAYLGGLIGSND 171
+A FLY+F+ L P ++L+ST+PIGAGLGSSAS+ V L+ A + + L G +
Sbjct: 203 SASAFLYLFLSLGSPQTPGAIYTLRSTIPIGAGLGSSASVCVCLSAALLLQIRTLAGPHP 262
Query: 172 LEKLSEND--KHIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFK 229
+ E + +N+WAF+GE C HG PSG+DN V+ G A++F ++ +
Sbjct: 263 DQPPDEAETQIERINRWAFVGEMCTHGNPSGVDNTVSAGGKAVIFRREDYT---KPPTVI 319
Query: 230 FLDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTK 289
L +FP +P++L TR RST VA+V L + P V + ILDA+ + L E +
Sbjct: 320 PLPNFPELPLLLVDTRQARSTAAEVAKVGKL-KDDHPVVTEAILDAIDKVTLAAQEAIQD 378
Query: 290 LSKCKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKL 349
++ + E L LIRINHG LVS+GVSHP LE I+ L D IG TKL
Sbjct: 379 INSKGVSAQI--------LEHLGTLIRINHGFLVSLGVSHPRLERIRELVDYANIGWTKL 430
Query: 350 TGAGGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLL 399
TGAGGGGC++T+LR D+ +E + ++KL +E +ET LGG G +L
Sbjct: 431 TGAGGGGCAITVLRPDVKEEAVRDLEQKL-SVEGFEKYETTLGGDGIGVL 479
>ref|XP_001821298.1| hypothetical protein [Aspergillus oryzae RIB40]
dbj|BAE59296.1| unnamed protein product [Aspergillus oryzae]
Length = 534
Score = 355 bits (911), Expect = 4e-96, Method: Composition-based stats.
Identities = 156/410 (38%), Positives = 225/410 (54%), Gaps = 26/410 (6%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFN 60
M+ F+ SAPGKVI+FGEH+ V+ K A+AA++S L+ + + + TI L+F DI N
Sbjct: 86 MAPAFMVSAPGKVIVFGEHAVVHGKAAMAAAISLRSYLLVTTLTKSQRTITLNFRDIGLN 145
Query: 61 HKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQL-------SESFHYH 113
H WSI++ Q +K + EL+ + PL+ ++
Sbjct: 146 HTWSIDELPWDLFHQPTKKKYY--YDLVTSIDPELLDAILPLVERISPDLPEDKRKHQRG 203
Query: 114 AAFCFLYMFVCLC-PHAKNIKFSLKSTLPIGAGLGSSASISVSLALA-MAYLGGLIGSND 171
AA FLY+F L P ++L+ST+P GAGLGSSASI V ++ A + + L G +
Sbjct: 204 AATAFLYLFCALGSPQHPGAIYTLRSTIPTGAGLGSSASICVCISAALLLQIRTLAGPHP 263
Query: 172 LEKLSENDK--HIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFK 229
+ E + +N+WAF+GE CIHG PSG+DN VA G A++F + ++
Sbjct: 264 DQPPDEAEVQIERINRWAFVGEMCIHGNPSGVDNTVAAGGKAVIFRRGDYS---KPPAVS 320
Query: 230 FLDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTK 289
L +FP +P++L TR RST VA+V L E+ P V + ILD + + EI+ +
Sbjct: 321 SLPNFPELPLLLVDTRQSRSTAVEVAKVGQL-KEEQPLVTEAILDTIEKVNASAQEIIRE 379
Query: 290 LSKCKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKL 349
+ + E++ LIRINHGLLVS+GVSHP LE I+ L D IG TKL
Sbjct: 380 TDSSGI--------SKDTLERIGALIRINHGLLVSLGVSHPRLERIRELVDFANIGWTKL 431
Query: 350 TGAGGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLL 399
TGAGGGGC++TLLR D I ++KL ++ + +ET LGG G +L
Sbjct: 432 TGAGGGGCAITLLRPDADPSAIRQLEEKLDEE-GFAKYETTLGGDGVGVL 480
>ref|XP_001267243.1| mevalonate kinase [Neosartorya fischeri NRRL 181]
gb|EAW25346.1| mevalonate kinase [Neosartorya fischeri NRRL 181]
Length = 538
Score = 355 bits (910), Expect = 5e-96, Method: Composition-based stats.
Identities = 152/410 (37%), Positives = 225/410 (54%), Gaps = 26/410 (6%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFN 60
M+ F+ SAPGKVI++GEH+ V+ K A+AA++S L+ + S + TI ++F DI +
Sbjct: 88 MAPAFMVSAPGKVIVYGEHAVVHGKAAMAAAISLRSYLLVTTLSKSQRTITMNFRDIGLD 147
Query: 61 HKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLS-------ESFHYH 113
H W+I++ + +K L ELV+ + P +S H
Sbjct: 148 HTWNIDELPWDVFHHPSKKKFY--YDLVTSLDPELVAAIQPHADAVSPEKPEDVRKIHRR 205
Query: 114 AAFCFLYMFVCLC-PHAKNIKFSLKSTLPIGAGLGSSASISVSLALA-MAYLGGLIGSND 171
+A FLY+F+ L ++L+ST+PIGAGLGSSAS+ V L+ A + + L G +
Sbjct: 206 SASAFLYLFLSLGSSQNPGAIYTLRSTIPIGAGLGSSASVCVCLSAALLLQIRTLAGPHP 265
Query: 172 LEKLSENDK--HIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFK 229
+ E + +N+WAF+GE C HG PSG+DN V+ G A++F ++ ++
Sbjct: 266 DQPPDEAEVQIERINRWAFVGEMCTHGNPSGVDNTVSAGGKAVVFRREDYS---KPPTVT 322
Query: 230 FLDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTK 289
L +FP +P++L TR RST VA+V L E P V IL+A+ + L + + +
Sbjct: 323 PLLNFPELPLLLVDTRQSRSTAVEVAKVGKLKDE-HPVVADSILEAIDQVTLAAQQKIQE 381
Query: 290 LSKCKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKL 349
+S + E L LIRINHG LVS+GVSHP LE I+ L D IG TKL
Sbjct: 382 ISTNGI--------SERTLEDLGTLIRINHGFLVSLGVSHPRLERIRELVDYADIGWTKL 433
Query: 350 TGAGGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLL 399
TGAGGGGC++TLLR D +E + ++KL + + +ET LGG G +L
Sbjct: 434 TGAGGGGCAITLLRPDTKEEAVRELEEKL-NAEGFVKYETTLGGDGIGVL 482
>gb|EDP50156.1| mevalonate kinase [Aspergillus fumigatus A1163]
Length = 538
Score = 355 bits (910), Expect = 5e-96, Method: Composition-based stats.
Identities = 153/410 (37%), Positives = 226/410 (55%), Gaps = 26/410 (6%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFN 60
M+ F+ SAPGKVI++GEH+ V+ K A+AA++S L+ + S + TI ++F DI +
Sbjct: 88 MAPAFMVSAPGKVIVYGEHAVVHGKAAMAAAISLRSYLLVTTLSKSQRTITMNFRDIGLD 147
Query: 61 HKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLS-------ESFHYH 113
H W+I++ + +K L ELV+ + P +S H
Sbjct: 148 HTWNIDELPWDVFHHPSKKKFY--YDLVTSLDPELVAAIQPHADAVSPDKPEDVRKIHRR 205
Query: 114 AAFCFLYMFVCLC-PHAKNIKFSLKSTLPIGAGLGSSASISVSLALA-MAYLGGLIGSND 171
+A FLY+F+ L ++L+ST+PIGAGLGSSAS+ V L+ A + + L G +
Sbjct: 206 SASAFLYLFLSLGSSQNPGAIYTLRSTIPIGAGLGSSASVCVCLSAALLLQIRTLAGPHP 265
Query: 172 LEKLSENDK--HIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFK 229
+ E + +N+WAF+GE C HG PSG+DN V+ G A++F ++ ++
Sbjct: 266 DQPPDEAEVQIERINRWAFVGEMCTHGNPSGVDNTVSAGGKAVVFRREDYS---KPPTVT 322
Query: 230 FLDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTK 289
L +FP +P++L TR RST VA+V L E +P V IL+A+ + L + + +
Sbjct: 323 PLLNFPELPLLLVDTRQSRSTAVEVAKVGKLKDE-YPVVTDSILEAIDQVTLAAQQKIQE 381
Query: 290 LSKCKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKL 349
+S + E L LIRINHG LVS+GVSHP LE I+ L D IG TKL
Sbjct: 382 ISTNGI--------SYRTLEDLGTLIRINHGFLVSLGVSHPRLERIRELVDYADIGWTKL 433
Query: 350 TGAGGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLL 399
TGAGGGGC++TLLR DI +E + ++KL + +ET LGG G +L
Sbjct: 434 TGAGGGGCAITLLRPDIKEEAVRELEEKL-SAEGFVKYETTLGGDGIGVL 482
>gb|EEH48028.1| mevalonate kinase [Paracoccidioides brasiliensis Pb18]
Length = 490
Score = 355 bits (910), Expect = 5e-96, Method: Composition-based stats.
Identities = 152/410 (37%), Positives = 224/410 (54%), Gaps = 26/410 (6%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFN 60
M+ F+ SAPGKVI+FGEH+ V+ K A+AA++S L+ + S + TI L+F DI +
Sbjct: 38 MAPAFMVSAPGKVIVFGEHAVVHGKRAMAAAISLRSYLLVTTLSKSQRTITLNFRDIELD 97
Query: 61 HKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLS-------ESFHYH 113
H W+I+ Q + +K + L EL+ + P +A +S H
Sbjct: 98 HTWNIDSLPWALFCQPSKKKFY--YDSVTSLDPELLEAIQPHIADISIGKPDEVRKIHRS 155
Query: 114 AAFCFLYMFVCLCPHAKNIKF-SLKSTLPIGAGLGSSASISVSLALAMA-YLGGLIGSND 171
+A FLY+F+ L + +L+ST+PIGAGLGSSASI+V L+ A+ + L G +
Sbjct: 156 SATAFLYLFLSLSSPDSHAAIYTLRSTIPIGAGLGSSASIAVCLSAALLLQIRILAGPHQ 215
Query: 172 LEKLSENDK--HIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFK 229
+ E + +N+WAF+GE CIHG PSG+DN V+ G A++F + ++ +
Sbjct: 216 DQPPEEAEVQIERINRWAFVGEMCIHGNPSGVDNTVSAGGKAVIFRRGDYS---KPPSVT 272
Query: 230 FLDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTK 289
+ DFP +P++L +R PRST VA+V + P V + L A+ +
Sbjct: 273 PILDFPELPLLLVNSRQPRSTATEVAKVGR-FCKAHPAVAESTLAAIDQVTESA------ 325
Query: 290 LSKCKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKL 349
+ +NE + EL RINHGLLVS+GVSHP LE I+ L D IG TKL
Sbjct: 326 --NNFIQSGRFDKDSNEDIDHFGELFRINHGLLVSLGVSHPRLERIRELVDHAGIGWTKL 383
Query: 350 TGAGGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLL 399
TGAGGGGC++ LLR + Q + ++ L D+ +E +ET LGG G +L
Sbjct: 384 TGAGGGGCAIVLLRANTNQAVLHHLEQNLDDE-GFERYETTLGGNGIGVL 432
>ref|XP_001241830.1| hypothetical protein CIMG_05726 [Coccidioides immitis RS]
gb|EAS30247.1| hypothetical protein CIMG_05726 [Coccidioides immitis RS]
Length = 612
Score = 353 bits (906), Expect = 2e-95, Method: Composition-based stats.
Identities = 144/410 (35%), Positives = 225/410 (54%), Gaps = 26/410 (6%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFN 60
M+ PF+ SAPGKVI+FGEH+ V+ K A+AA++S L+ + S + T+ L+F D +
Sbjct: 163 MAPPFMVSAPGKVIVFGEHAVVHGKKAMAAAISLRSYLLVTTLSKSRRTVTLNFRDTGLD 222
Query: 61 HKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLS-------ESFHYH 113
H W I+ + + +K L +L+ + P ++ +S H
Sbjct: 223 HTWDIDSLPWDVFNHSSKKKFY--YDRVTSLDPDLLDAIRPHISNVSPDKPPEVRKVHQG 280
Query: 114 AAFCFLYMFVCLC-PHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMA-YLGGLIGSND 171
+A FLY+++ L P + ++L+ST+PIGAGLGSSAS+ V L+ A+ + L G +
Sbjct: 281 SASAFLYLYLSLGSPQSHGAIYTLRSTIPIGAGLGSSASVCVCLSAALLLQIRALAGPHP 340
Query: 172 LEKLSENDK--HIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFK 229
+ E++ +N+WAF+GE CIHG PSG+DN V+ G A++F + ++
Sbjct: 341 DQPFDESEVQIERINRWAFVGELCIHGNPSGVDNTVSAGGKAVIFRRGDYS---KPPTVI 397
Query: 230 FLDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTK 289
+ DFP +P++L +R RST VA+V L P + +LD + + + ++
Sbjct: 398 PILDFPELPLLLVNSRQSRSTATEVAKVGTLKK-LHPAITDCLLDGIDQVTTSAHDFISS 456
Query: 290 LSKCKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKL 349
+ + ++E L RINHGLLVS+GVSHP LE I+ L D IG TKL
Sbjct: 457 EN--------FDKNSSETLNYFGTLFRINHGLLVSLGVSHPRLERIRELVDHTGIGWTKL 508
Query: 350 TGAGGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLL 399
TGAGGGGC++TL+R D + +++L ++ YE +ET LGG G +L
Sbjct: 509 TGAGGGGCAITLIRTDRESTALKPLERQLDEE-GYERYETTLGGQGVGVL 557
>ref|XP_001401587.1| hypothetical protein An04g02190 [Aspergillus niger]
emb|CAL00706.1| unnamed protein product [Aspergillus niger]
Length = 448
Score = 352 bits (903), Expect = 3e-95, Method: Composition-based stats.
Identities = 155/410 (37%), Positives = 228/410 (55%), Gaps = 26/410 (6%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFN 60
M+ PF+ SAPGKVI+FGEH+ V+ K A+AA++S +L+ + S + TI L+ D+ FN
Sbjct: 1 MAPPFMVSAPGKVIVFGEHAVVHGKAAMAAAISLRSYFLVTTLSKSQRTITLNLRDMDFN 60
Query: 61 HKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLS-------ESFHYH 113
H W+I+D Q + +K L +EL L P + +S H
Sbjct: 61 HTWNIDDLPWDFFKQPSKKKYY--YDLVTSLDEELYDSLKPCVEDISPKAPEEIRKKHKG 118
Query: 114 AAFCFLYMFVCLC-PHAKNIKFSLKSTLPIGAGLGSSASISVSLALA-MAYLGGLIGSND 171
+A FLY+F L P ++L+ST+P+GAGLGSSAS+ + A + + L G +D
Sbjct: 119 SALAFLYLFCSLGSPQHPGAIYTLRSTIPMGAGLGSSASVCTCFSAALLLQIRTLAGPHD 178
Query: 172 LEKLSENDK--HIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFK 229
+ E + +N+WAF+GE CIHG PSG+DN V+T G A++F ++ ++
Sbjct: 179 DQPPDEAELQIERINRWAFVGELCIHGNPSGVDNTVSTGGKAVIFRREDYSKPPK---VI 235
Query: 230 FLDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTK 289
L +FP +P++L TR RST VA+V L E P V + ILDA+ + + +
Sbjct: 236 PLPNFPELPLLLVDTRQSRSTAVEVAKVGKLKKE-HPLVTESILDAIDKVTVSAQSAIQ- 293
Query: 290 LSKCKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKL 349
E + E E + L+R+NHG LVS+GVSHP LE I+ L D IG TKL
Sbjct: 294 -------GVEGDSIDKETLEHIGTLVRVNHGFLVSLGVSHPRLERIRELVDFANIGWTKL 346
Query: 350 TGAGGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLL 399
TGAGGGGC++TLLR D + + + ++KL ++ +ET LGG G +L
Sbjct: 347 TGAGGGGCAITLLRPDASVDALRELERKL-AAENFSKYETTLGGDGIGVL 395
>ref|XP_370449.1| hypothetical protein MGG_06946 [Magnaporthe grisea 70-15]
gb|EDJ98120.1| hypothetical protein MGG_06946 [Magnaporthe grisea 70-15]
Length = 494
Score = 350 bits (897), Expect = 2e-94, Method: Composition-based stats.
Identities = 158/399 (39%), Positives = 232/399 (58%), Gaps = 28/399 (7%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISE-SSAPDTIELDFPDISF 59
M F+ SAPGKVI+FGEHS VY K AVAA+++ LR+YLL++ S + TI L FPDI
Sbjct: 43 MMPAFMVSAPGKVIVFGEHSVVYGKKAVAAAIN-LRSYLLVTALSKSKRTITLRFPDIDL 101
Query: 60 NHKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLS-------ESFHY 112
H W+I+D T Q + +K L +L+ + P L +S H
Sbjct: 102 IHTWNIDDLPWSTFSQPSKKKYY--YDLVTSLDPDLMDAIQPHLEPVSSDAPDAQRKVHM 159
Query: 113 HAAFCFLYMFVCLCPHA-KNIKFSLKSTLPIGAGLGSSASISVSLALAMA-YLGGLIGSN 170
AA FLY+F+ L HA ++L+ST+PIGAGLGSSASIS L+ A+ + L G +
Sbjct: 160 SAAAAFLYLFMSLGSHAFPGGIYTLRSTIPIGAGLGSSASISACLSAALLLQIRTLSGPH 219
Query: 171 DLEKLSENDK--HIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNF 228
+ E +N+WAF+ E CIHG PSG+DN V+T G A++F++ +
Sbjct: 220 PDQPPDEARVQVERINRWAFVAEMCIHGNPSGVDNTVSTQGKAVVFQRLDYARPPV---V 276
Query: 229 KFLDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMT 288
+ DFP +P+++ T+ +STK V +V L E P+++ ILD+M + +++
Sbjct: 277 TPMWDFPELPLLVVDTKQAKSTKYEVEKVAKL-RETHPKIVNSILDSMDKLTQAATDVL- 334
Query: 289 KLSKCKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTK 348
TD++ + E +++ EL+ +NHGLLVS+GVSHP LE ++ L D IG TK
Sbjct: 335 -------TDEDFDNEDVESLQKVGELMGMNHGLLVSLGVSHPRLERVRELVDHEGIGWTK 387
Query: 349 LTGAGGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETF 387
LTGAGGGGCS+TL+R D+ +E+++ K++L D Y F
Sbjct: 388 LTGAGGGGCSITLMRPDVPREKLERLKERL-DHEGYLKF 425
>ref|XP_446138.1| unnamed protein product [Candida glabrata]
emb|CAG59062.1| unnamed protein product [Candida glabrata CBS 138]
Length = 430
Score = 350 bits (897), Expect = 2e-94, Method: Composition-based stats.
Identities = 238/448 (53%), Positives = 307/448 (68%), Gaps = 35/448 (7%)
Query: 3 LPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISE--SSAPDTIELDFPDISFN 60
LPFL SAPGKVI+FGEHSAVYN+PAVAASVS+LRTYLL+S S+A D+IEL FPDI F+
Sbjct: 7 LPFLVSAPGKVILFGEHSAVYNEPAVAASVSSLRTYLLVSPAGSNAEDSIELSFPDIGFD 66
Query: 61 HKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLY 120
H W + + + L A++ T L++ELV LL+ +L L ES HYHAAFCFLY
Sbjct: 67 HVWKRKELEPVLRETA---LLQAAREDTKNLNEELVGLLNVILEPLKESLHYHAAFCFLY 123
Query: 121 MFVCLCPHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLIGSNDLEKLSENDK 180
+F LCP A NIKFS+KSTLPIGAGLGSSA+ISVSLA+AM LGG + + + LS DK
Sbjct: 124 LFCTLCPSATNIKFSVKSTLPIGAGLGSSAAISVSLAMAMLRLGGKLVTGE--SLSGEDK 181
Query: 181 HIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLDDFPAIPM- 239
++N+WAFIGEKCIHGTPSGIDNAVATYGNA+LF++ + T +F+FLD F + +
Sbjct: 182 ALINEWAFIGEKCIHGTPSGIDNAVATYGNAVLFKRSADG----TTDFEFLDKFHELKIP 237
Query: 240 -ILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSKCKGTDD 298
+LTYTRIPRSTK LV+ VR L + + ++ AMGE AL+ ++I+
Sbjct: 238 MVLTYTRIPRSTKVLVSSVRDLSNKYPKVIQDHVIKAMGELALESVDILNSGI------- 290
Query: 299 EAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGAGGGGCS 358
N+ YE+LL+L+ INHGLLV+IGVSHPGLE+I+NLS IG+TKLTGAGGGGC+
Sbjct: 291 ---GGNDSNYERLLDLVNINHGLLVAIGVSHPGLEIIRNLSITNSIGATKLTGAGGGGCA 347
Query: 359 LTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCL---LSAKNLNKDLKIKSLVF 415
T+L +D+ Q ++D FK++L Y +F ++LGG G C+ L A+ N LV
Sbjct: 348 FTVLNKDVPQTEVDKFKEELSKKHGYLSFTSELGGAGSCMTPTLVAEQYN-------LVA 400
Query: 416 QLFENKTTTKQQIDDLLLPGNT--NLPW 441
LFEN K+++D LLP +L W
Sbjct: 401 PLFENTENNKEELDKTLLPATATNSLFW 428
>ref|XP_452532.1| unnamed protein product [Kluyveromyces lactis]
emb|CAH01383.1| unnamed protein product [Kluyveromyces lactis NRRL Y-1140]
Length = 419
Score = 345 bits (884), Expect = 5e-93, Method: Composition-based stats.
Identities = 225/441 (51%), Positives = 296/441 (67%), Gaps = 32/441 (7%)
Query: 4 PFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFNHKW 63
PF+ SAPGKVIIFGEHSAV+NK A+AASVS+LRTYLLI +S D +ELDFPDI+++ KW
Sbjct: 10 PFIVSAPGKVIIFGEHSAVFNKNAIAASVSSLRTYLLIEQSKDGDGVELDFPDINYDSKW 69
Query: 64 SINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLYMFV 123
S + I + V L +L L+ LL L +S +Y+AA FLY+++
Sbjct: 70 STEELKTIDSEVVKQ------AAGLKHLCPKLKEQLNLLLEGLKDSLNYYAALSFLYLYL 123
Query: 124 CLCPHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLIGSNDLEKLSENDKHIV 183
LCP+ K +KF++KSTLPIGAGLGSSASISV LALAMA +GG I + + +S+ +K +
Sbjct: 124 SLCPNVKGLKFTVKSTLPIGAGLGSSASISVCLALAMARMGGHISCD--KSISQEEKEFI 181
Query: 184 NQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLDDFPAIPMILTY 243
N WAFIGE CIHGTPSGIDNAVATYGNA+ F++ T F + +FP +PM+LT
Sbjct: 182 NHWAFIGECCIHGTPSGIDNAVATYGNAVKFKRQEDGST----KFDQISNFPQLPMVLTN 237
Query: 244 TRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSKCKGTDDEAVET 303
TRI RSTK LV+ V LV K P + +PIL+AM + AL+G E+++ +SK
Sbjct: 238 TRIKRSTKILVSGVGDLVNRK-PLITEPILEAMNQVALRGSELLSDISK----------- 285
Query: 304 NNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGAGGGGCSLTLLR 363
+ Y++LLELIRINHGLLV+IGVSHPGLE+IK LSD+L+IG TKLTGAGGGGC+ TLL
Sbjct: 286 -DIHYDELLELIRINHGLLVAIGVSHPGLEVIKQLSDELKIGQTKLTGAGGGGCAFTLLN 344
Query: 364 RDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLNKDLKIKSLVFQLFENKTT 423
+D+ + F +KL ++ Y+ FET LGG GCC + KN + +K L +
Sbjct: 345 KDVDHSSVRKFHEKLHSNYGYQIFETGLGGVGCCFVDLKNEQYE-SLKHLFID-----SA 398
Query: 424 TKQQIDDLLLPG-NTNLPWTS 443
T Q++ LLP + +L WT+
Sbjct: 399 TVQEVSLALLPSPDGSLTWTA 419
>ref|XP_001483309.1| hypothetical protein PGUG_04038 [Pichia guilliermondii ATCC 6260]
gb|EDK39940.1| hypothetical protein PGUG_04038 [Pichia guilliermondii ATCC 6260]
Length = 423
Score = 336 bits (863), Expect = 1e-90, Method: Composition-based stats.
Identities = 164/436 (37%), Positives = 245/436 (56%), Gaps = 27/436 (6%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFN 60
M+ F SAPGKVI+FGEH+AVY KPA+AA + L++ + D++ L+FPDI +
Sbjct: 1 MAP-FYISAPGKVILFGEHAAVYGKPALAA--ALSLRAYLLATETNDDSLRLEFPDIQLS 57
Query: 61 HKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLY 120
H W +++ Q + ++ TD L+ E+++L+ L + + HY CFLY
Sbjct: 58 HSWKLSELPWEN-AQAHIERKNGKPVPTDELNPEVINLIGEFLGDIESTAHYTTCLCFLY 116
Query: 121 MFVCLCPH-AKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLIGSNDLEKLS--- 176
+++ LC + F ++STLPIGAGLGSSAS +V L +A LGG I S +
Sbjct: 117 LYLHLCDPLVASRSFCIRSTLPIGAGLGSSASAAVCLTSTLALLGGHIRSPQYSEKQRVS 176
Query: 177 --ENDKHIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLDDF 234
D ++ W+ +GEKC HG PSGIDNAVAT+G A+++++ + + +F
Sbjct: 177 SENPDAEFIDSWSLMGEKCFHGNPSGIDNAVATHGGAVMYQRMLAPDMPSVRT--AMRNF 234
Query: 235 PAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSKCK 294
P + ++LT T++PRST +LV V V + P+ ILDA+ A IM+ S
Sbjct: 235 PPLKLLLTNTKVPRSTAELVGGVAK-VNTRHPKTAGSILDAVSHLATDAYHIMSHPSFAA 293
Query: 295 GTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGAGG 354
E E L +L+ INHGLLV++GVSHP LE IK + D RIG+TKLTGAGG
Sbjct: 294 -----------EDRESLRQLVNINHGLLVALGVSHPALEKIKMIGDTNRIGATKLTGAGG 342
Query: 355 GGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLNKDLKIKSL- 413
GGC++TLL +++ E ++ + + + +ETFE LGG G L N + D ++ S+
Sbjct: 343 GGCAITLLNDEVSHEVLEKVENEFTQE-GFETFEATLGGKGVGALFCDN-DSDPEVFSVE 400
Query: 414 VFQLFENKTTTKQQID 429
F F + K ++
Sbjct: 401 RFVNFSRREDIKNALE 416
>gb|EEH37797.1| mevalonate kinase [Paracoccidioides brasiliensis Pb01]
Length = 545
Score = 326 bits (836), Expect = 2e-87, Method: Composition-based stats.
Identities = 145/410 (35%), Positives = 215/410 (52%), Gaps = 42/410 (10%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFN 60
M+ F+ SAPGKVI+FGEH+ V+ K A+AA++S L+ + S + TI L+F DI +
Sbjct: 109 MAPAFMVSAPGKVIVFGEHAVVHGKRAMAAAISLRSYLLVTTLSKSQRTITLNFRDIELD 168
Query: 61 HKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLS-------ESFHYH 113
H W I+ Q + +K + L EL+ + P +A +S + H
Sbjct: 169 HTWDIDSLPWALFCQPSKKKFY--YDSVTSLDPELLEAIQPHIADISIGKPDEVQKIHRS 226
Query: 114 AAFCFLYMFVCLCPHAKNIKF-SLKSTLPIGAGLGSSASISVSLALAMA-YLGGLIGSND 171
+A FLY+F+ L + +L+ST+PIGAGLGSSASI+V L+ A+ + L G +
Sbjct: 227 SATAFLYLFLSLSSPGSHAAIYTLRSTIPIGAGLGSSASIAVCLSAALLLQIRILAGPHH 286
Query: 172 LEKLSENDK--HIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFK 229
+ E + +N+WAF+GE CIHG PSG+DN V+ G A++F + ++ +
Sbjct: 287 DQPPEEAEVQIERINRWAFVGEMCIHGNPSGVDNTVSAGGKAVIFRRGDYS---KPPSVT 343
Query: 230 FLDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTK 289
+ DFP +P++L + P P V + L A+ +
Sbjct: 344 PILDFPELPLLLAGSAKPT-----------------PAVAESTLAAIDQVTESA------ 380
Query: 290 LSKCKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKL 349
+ +NE + EL RINHGLLVS+GVSHP LE I+ L D IG TKL
Sbjct: 381 --NNFIQSGRFDKDSNEDIDHFGELFRINHGLLVSLGVSHPRLERIRELVDHAGIGWTKL 438
Query: 350 TGAGGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLL 399
TGAGGGGC++ LLR + Q + ++ L D+ +E +ET LGG G +L
Sbjct: 439 TGAGGGGCAIVLLRANTNQAVLHHLEQNLDDE-GFERYETTLGGDGIGVL 487
>emb|CAA53059.1| unnamed protein product [Hepatitis B virus]
Length = 557
Score = 320 bits (820), Expect = 1e-85, Method: Composition-based stats.
Identities = 127/417 (30%), Positives = 215/417 (51%), Gaps = 36/417 (8%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFN 60
+S L SAPGKVI+ GEH+ V+ K A+A S++ LRT+L + + ++L P+I
Sbjct: 163 LSEVLLVSAPGKVILHGEHAVVHGKVALAVSLN-LRTFLRLQP-HSNGKVDLSLPNIGIK 220
Query: 61 HKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLY 120
W + ++ + + +E+ L D A FLY
Sbjct: 221 RAWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAV-----TERLAVLAFLY 275
Query: 121 MFVCLCPH---AKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGG-----LIGSNDL 172
+++ +C ++ + S LP GAGLGSSA+ SV LA A+ + L + +
Sbjct: 276 LYLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCV 335
Query: 173 EKLSENDKHIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLD 232
+ ++ D ++N+WAF GE+ IHG PSG+DNAV+T+G AL + + L
Sbjct: 336 NRWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQG---------KISSLK 386
Query: 233 DFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSK 292
PA+ ++LT T++PR+T+ LVA VR + KFPE++ P+L ++ +L+ ++ ++ +
Sbjct: 387 RSPALQILLTNTKVPRNTRALVAGVRNRLL-KFPEIVAPLLTSIDAISLECERVLGEMGE 445
Query: 293 CKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGA 352
E Y L ELI +N L ++GV H L+ + ++ +KLTGA
Sbjct: 446 APA---------PEQYLVLEELIDMNQHHLNALGVGHASLDQLCQVTRARG-LHSKLTGA 495
Query: 353 GGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLNKDLK 409
GGGGC +TLL+ + Q ++++ K+ L ++ ET +G G + SA +L+ ++
Sbjct: 496 GGGGCGITLLKPGLEQPEVEATKQALT-SCGFDCLETSIGAPGVSIHSATSLDSRVQ 551
>ref|XP_001105759.1| PREDICTED: mevalonate kinase isoform 2 [Macaca mulatta]
ref|XP_001105815.1| PREDICTED: mevalonate kinase isoform 3 [Macaca mulatta]
Length = 396
Score = 317 bits (813), Expect = 1e-84, Method: Composition-based stats.
Identities = 126/417 (30%), Positives = 215/417 (51%), Gaps = 36/417 (8%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFN 60
+S L SAPGKVI+ GEH+ V+ K A+A +++ LRT+L + + ++L P+I
Sbjct: 2 LSEVLLVSAPGKVILHGEHAVVHGKVALAVALN-LRTFLRLQP-HSNGKVDLSLPNIGIK 59
Query: 61 HKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLY 120
W + + + +E+ L D A FLY
Sbjct: 60 WAWDVARLQLLDTSFLEQGDATTPTPELVEKLKEVAGLPDDCAV-----TESLAVLAFLY 114
Query: 121 MFVCLCPH---AKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGG-----LIGSNDL 172
+++ +C ++ + S LP GAGLGSSA+ SV LA A+ + L + +
Sbjct: 115 LYLSICRKQRALPSLDIVVWSELPHGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDRV 174
Query: 173 EKLSENDKHIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLD 232
+ ++ D ++N+WAF GE+ IHG PSG+DNAV+T+G AL +++ L
Sbjct: 175 NRWTKEDLELINKWAFQGERVIHGNPSGVDNAVSTWGGALRYQQG---------KISSLK 225
Query: 233 DFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSK 292
PA+ ++LT T++PR+T+ LVA VR + KFPE++ P+L ++ +L+ ++ ++ +
Sbjct: 226 RPPALQILLTNTKVPRNTRTLVAGVRNRLL-KFPEIVAPLLTSIDAISLECERVLGEMGE 284
Query: 293 CKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGA 352
E Y L ELI +N L ++GV H L+ + ++ +KLTGA
Sbjct: 285 APA---------PEQYLVLEELIDMNQHHLNALGVGHASLDQLCQVTRAHG-LHSKLTGA 334
Query: 353 GGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLNKDLK 409
GGGGC +TLL+ + Q ++++ K+ L ++ +ET +G G + SA +L+ ++
Sbjct: 335 GGGGCGITLLKPGLEQPEVEATKQALT-SCGFDCWETSIGAPGVSIHSATSLDSRVQ 390
>gb|AAX08684.1| mevalonate kinase [Bos taurus]
Length = 396
Score = 310 bits (795), Expect = 1e-82, Method: Composition-based stats.
Identities = 126/417 (30%), Positives = 212/417 (50%), Gaps = 36/417 (8%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFN 60
+S L SAPGKVI+ GEH+ V+ K A+A +++ LRT+L + + + L+ P+I
Sbjct: 2 LSEVLLVSAPGKVILHGEHAVVHGKVALAVALN-LRTFLRLQP-HSNGRVGLNLPNIGVR 59
Query: 61 HKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLY 120
W + + + A +E+ + + A FLY
Sbjct: 60 RAWDVASLQLLDTSFLGHGDSAALTAKHVEKLKEVAGFPKDCVDP-----EHLAVLAFLY 114
Query: 121 MFVCLCPH---AKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGG-----LIGSNDL 172
+++ +C ++ ++ S LP GAGLGSSA+ SV LA A+ L
Sbjct: 115 LYLSICQSQRVLPSLDITVWSELPTGAGLGSSAAYSVCLAAALLTACEEIPNPLKDGEAA 174
Query: 173 EKLSENDKHIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLD 232
+ +E + ++N+WAF GE+ IHG PSG+DNAV+T+G AL +++ L
Sbjct: 175 GRWTEENLELINKWAFQGERVIHGNPSGVDNAVSTWGGALRYQQG---------KISSLK 225
Query: 233 DFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSK 292
P + ++L T++PRSTK LVA VR + KFPE++ P+L ++ +L+ ++ ++
Sbjct: 226 RPPVLKILLINTKVPRSTKVLVANVRSRLL-KFPEIVAPLLTSIDAISLECERVLGEM-- 282
Query: 293 CKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGA 352
A E Y L ELI +N L ++GV H L+ + ++ +KLTGA
Sbjct: 283 -------AAAPTPEHYLTLEELIDMNQHHLNALGVGHASLDQLCQVTTAHG-LHSKLTGA 334
Query: 353 GGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLNKDLK 409
GGGGC +TLLR D+ + +++ K+ L ++ +ET +G G + +A +L+ ++
Sbjct: 335 GGGGCGITLLRPDVERPAVEATKRALSG-CGFDCWETSVGAPGVSVHTAASLDASVQ 390
>ref|NP_001015528.1| mevalonate kinase [Bos taurus]
sp|Q5E9T8|KIME_BOVIN Mevalonate kinase (MK)
gb|AAX08849.1| mevalonate kinase [Bos taurus]
gb|AAI04541.1| Mevalonate kinase (mevalonic aciduria) [Bos taurus]
Length = 396
Score = 310 bits (794), Expect = 2e-82, Method: Composition-based stats.
Identities = 126/417 (30%), Positives = 212/417 (50%), Gaps = 36/417 (8%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFN 60
+S L SAPGKVI+ GEH+ V+ K A+A +++ LRT+L + + + L+ P+I
Sbjct: 2 LSEVLLVSAPGKVILHGEHAVVHGKVALAVALN-LRTFLRLQP-HSNGRVGLNLPNIGVR 59
Query: 61 HKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLY 120
W + + + A +E+ + + A FLY
Sbjct: 60 RAWDVASLQLLDTSFLGHGDSAALTAKHVEKLKEVAGFPKDCVDP-----EHLAVLAFLY 114
Query: 121 MFVCLCPH---AKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGG-----LIGSNDL 172
+++ +C ++ ++ S LP GAGLGSSA+ SV LA A+ L
Sbjct: 115 LYLSICQSQRALPSLDITVWSELPTGAGLGSSAAYSVCLAAALLTACEEIPNPLKDGEAA 174
Query: 173 EKLSENDKHIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLD 232
+ +E + ++N+WAF GE+ IHG PSG+DNAV+T+G AL +++ L
Sbjct: 175 GRWTEENLELINKWAFQGERVIHGNPSGVDNAVSTWGGALRYQQG---------KISSLK 225
Query: 233 DFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSK 292
P + ++L T++PRSTK LVA VR + KFPE++ P+L ++ +L+ ++ ++
Sbjct: 226 RPPVLKILLINTKVPRSTKVLVANVRSRLL-KFPEIVAPLLTSIDAISLECERVLGEM-- 282
Query: 293 CKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGA 352
A E Y L ELI +N L ++GV H L+ + ++ +KLTGA
Sbjct: 283 -------AAAPTPEHYLTLEELIDMNQHHLNALGVGHASLDQLCQVTTAHG-LHSKLTGA 334
Query: 353 GGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLNKDLK 409
GGGGC +TLLR D+ + +++ K+ L ++ +ET +G G + +A +L+ ++
Sbjct: 335 GGGGCGITLLRPDVERPAVEATKRALSG-CGFDCWETSVGAPGVSVHTAASLDASVQ 390
>dbj|BAD92959.1| mevalonate kinase variant [Homo sapiens]
Length = 421
Score = 309 bits (792), Expect = 2e-82, Method: Composition-based stats.
Identities = 127/417 (30%), Positives = 216/417 (51%), Gaps = 36/417 (8%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFN 60
+S L SAPGKVI+ GEH+ V+ K A+A S++ LRT+L + + ++L+ P+I
Sbjct: 27 LSEVLLVSAPGKVILHGEHAVVHGKVALAVSLN-LRTFLRLQP-HSNGKVDLNLPNIGIK 84
Query: 61 HKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLY 120
W + ++ + + +E+ L D A FLY
Sbjct: 85 RAWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAV-----TERLAVLAFLY 139
Query: 121 MFVCLCPH---AKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGG-----LIGSNDL 172
+++ +C ++ + S LP GAGLGSSA+ SV LA A+ + L + +
Sbjct: 140 LYLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCV 199
Query: 173 EKLSENDKHIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLD 232
+ ++ D ++N+WAF GE+ IHG PSG+DNAV+T+G AL + + L
Sbjct: 200 NRWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQG---------KISSLK 250
Query: 233 DFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSK 292
PA+ ++LT T++PR+T+ LVA VR + KFPE++ P+L ++ +L+ ++ ++ +
Sbjct: 251 RSPALQILLTNTKVPRNTRALVAGVRNRLL-KFPEIVAPLLTSIDAISLECERVLGEMGE 309
Query: 293 CKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGA 352
E Y L ELI +N L ++GV H L+ + ++ +KLTGA
Sbjct: 310 APA---------PEQYLVLEELIDMNQHHLNALGVGHASLDQLCQVTRARG-LHSKLTGA 359
Query: 353 GGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLNKDLK 409
GGGGC +TLL+ + Q ++++ K+ L ++ ET +G G + SA +L+ ++
Sbjct: 360 GGGGCGITLLKPGLEQPEVEATKQALT-SCGFDCLETSIGAPGVSIHSATSLDSRVQ 415
>ref|NP_000422.1| mevalonate kinase [Homo sapiens]
ref|NP_001107657.1| mevalonate kinase [Homo sapiens]
sp|Q03426|KIME_HUMAN Mevalonate kinase (MK)
gb|AAB59362.1| mevalonate kinase
emb|CAA53060.1| unnamed protein product [Homo sapiens]
gb|AAF82407.1| mevalonate kinase [Homo sapiens]
gb|AAH16140.1| MVK protein [Homo sapiens]
gb|EAW97872.1| mevalonate kinase (mevalonic aciduria), isoform CRA_c [Homo
sapiens]
gb|EAW97873.1| mevalonate kinase (mevalonic aciduria), isoform CRA_c [Homo
sapiens]
gb|ABM82015.1| mevalonate kinase (mevalonic aciduria) [synthetic construct]
gb|ABM85197.1| mevalonate kinase (mevalonic aciduria) [synthetic construct]
Length = 396
Score = 309 bits (791), Expect = 3e-82, Method: Composition-based stats.
Identities = 127/417 (30%), Positives = 215/417 (51%), Gaps = 36/417 (8%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFN 60
+S L SAPGKVI+ GEH+ V+ K A+A S++ LRT+L + + ++L P+I
Sbjct: 2 LSEVLLVSAPGKVILHGEHAVVHGKVALAVSLN-LRTFLRLQP-HSNGKVDLSLPNIGIK 59
Query: 61 HKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLY 120
W + ++ + + +E+ L D A FLY
Sbjct: 60 RAWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAV-----TERLAVLAFLY 114
Query: 121 MFVCLCPH---AKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGG-----LIGSNDL 172
+++ +C ++ + S LP GAGLGSSA+ SV LA A+ + L + +
Sbjct: 115 LYLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCV 174
Query: 173 EKLSENDKHIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLD 232
+ ++ D ++N+WAF GE+ IHG PSG+DNAV+T+G AL + + L
Sbjct: 175 NRWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQG---------KISSLK 225
Query: 233 DFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSK 292
PA+ ++LT T++PR+T+ LVA VR + KFPE++ P+L ++ +L+ ++ ++ +
Sbjct: 226 RSPALQILLTNTKVPRNTRALVAGVRNRLL-KFPEIVAPLLTSIDAISLECERVLGEMGE 284
Query: 293 CKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGA 352
E Y L ELI +N L ++GV H L+ + ++ +KLTGA
Sbjct: 285 APA---------PEQYLVLEELIDMNQHHLNALGVGHASLDQLCQVTRARG-LHSKLTGA 334
Query: 353 GGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLNKDLK 409
GGGGC +TLL+ + Q ++++ K+ L ++ ET +G G + SA +L+ ++
Sbjct: 335 GGGGCGITLLKPGLEQPEVEATKQALT-SCGFDCLETSIGAPGVSIHSATSLDSRVQ 390
>gb|AAQ02416.1| mevalonate kinase [synthetic construct]
Length = 397
Score = 309 bits (791), Expect = 4e-82, Method: Composition-based stats.
Identities = 127/417 (30%), Positives = 215/417 (51%), Gaps = 36/417 (8%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFN 60
+S L SAPGKVI+ GEH+ V+ K A+A S++ LRT+L + + ++L P+I
Sbjct: 2 LSEVLLVSAPGKVILHGEHAVVHGKVALAVSLN-LRTFLRLQP-HSNGKVDLSLPNIGIK 59
Query: 61 HKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLY 120
W + ++ + + +E+ L D A FLY
Sbjct: 60 RAWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAV-----TERLAVLAFLY 114
Query: 121 MFVCLCPH---AKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGG-----LIGSNDL 172
+++ +C ++ + S LP GAGLGSSA+ SV LA A+ + L + +
Sbjct: 115 LYLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCV 174
Query: 173 EKLSENDKHIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLD 232
+ ++ D ++N+WAF GE+ IHG PSG+DNAV+T+G AL + + L
Sbjct: 175 NRWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQG---------KISSLK 225
Query: 233 DFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSK 292
PA+ ++LT T++PR+T+ LVA VR + KFPE++ P+L ++ +L+ ++ ++ +
Sbjct: 226 RSPALQILLTNTKVPRNTRALVAGVRNRLL-KFPEIVAPLLTSIDAISLECERVLGEMGE 284
Query: 293 CKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGA 352
E Y L ELI +N L ++GV H L+ + ++ +KLTGA
Sbjct: 285 APA---------PEQYLVLEELIDMNQHHLNALGVGHASLDQLCQVTRARG-LHSKLTGA 334
Query: 353 GGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLNKDLK 409
GGGGC +TLL+ + Q ++++ K+ L ++ ET +G G + SA +L+ ++
Sbjct: 335 GGGGCGITLLKPGLEQPEVEATKQALT-SCGFDCLETSIGAPGVSIHSATSLDSRVQ 390
>ref|XP_543435.2| PREDICTED: similar to Mevalonate kinase (MK) [Canis familiaris]
Length = 409
Score = 306 bits (785), Expect = 2e-81, Method: Composition-based stats.
Identities = 128/417 (30%), Positives = 213/417 (51%), Gaps = 32/417 (7%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFN 60
+S L SAPGKVI+ GEH+ V+ K A+A +++ LRT+L + + + L+ P+I
Sbjct: 11 LSEVLLVSAPGKVILHGEHAVVHGKIALAVALN-LRTFLRLQP-HSNGKMCLNLPNIGVK 68
Query: 61 HKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLY 120
W + + A E + + + ++ A FLY
Sbjct: 69 RAWDVARLQLQDTSFLEPGNATGDAAAPTSEQVEKLKEVAGIPKDGADPEC-LAVLAFLY 127
Query: 121 MFVCLCPH---AKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLIGSN-----DL 172
+++ +C ++ ++ S LP GAGLGSSA+ SV LA A+ I +
Sbjct: 128 LYLSICRKQRTLPSLDITVWSELPTGAGLGSSAAYSVCLAAALLTACEAIPNPQNNGESA 187
Query: 173 EKLSENDKHIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLD 232
+ + D ++N+WAF GE+ IHG PSG+DN ++T+G AL +++ +
Sbjct: 188 SRWTMEDLELINKWAFQGERMIHGNPSGVDNTISTWGGALRYQQG---------KISSIK 238
Query: 233 DFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSK 292
PA+ ++LT T++PRSTK LVA VR + KFPE++ P+L ++ +L+ + ++
Sbjct: 239 RLPALKILLTNTKVPRSTKALVASVRSRLL-KFPEIVAPLLTSINAISLECERTLEEM-- 295
Query: 293 CKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGA 352
A E Y L ELI IN L ++GV H L+ + ++ +KLTGA
Sbjct: 296 -------ASAPAPEHYLVLEELIDINQHHLNALGVGHASLDQLCQVTMAHG-LHSKLTGA 347
Query: 353 GGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLNKDLK 409
GGGGC +TLLR D+ Q ++++ K+ L ++ +ET +G G + SA +L+ ++
Sbjct: 348 GGGGCGITLLRPDLEQPKVEAMKQALT-SCGFDCWETRIGAPGISIHSAASLDTQVQ 403
>ref|NP_112325.1| mevalonate kinase [Rattus norvegicus]
sp|P17256|KIME_RAT Mevalonate kinase (MK)
pdb|1KVK|A Chain A, The Structure Of Binary Complex Between A Mammalian
Mevalonate Kinase And Atp: Insights Into The Reaction
Mechanism And Human Inherited Disease
gb|AAA41588.1| mevalonate kinase (EC 2.7.1.36)
gb|EDM13937.1| mevalonate kinase, isoform CRA_a [Rattus norvegicus]
Length = 395
Score = 306 bits (784), Expect = 3e-81, Method: Composition-based stats.
Identities = 116/414 (28%), Positives = 200/414 (48%), Gaps = 30/414 (7%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFN 60
+S L SAPGKVI+ GEH+ V+ K A+A +++ L+ + + L+ P++
Sbjct: 2 LSEVLLVSAPGKVILHGEHAVVHGKVALAVALNL--RTFLVLRPQSNGKVSLNLPNVGIK 59
Query: 61 HKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLY 120
W + + + + +++ L + +E A
Sbjct: 60 QVWDVATLQLLDTGFLEQGDVPAPTLEQLEKLKKVAGLPRDCVG--NEGLSLLAFLYLYL 117
Query: 121 MFVCLCPHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGG-----LIGSNDLEKL 175
++ + S LP GAGLGSSA+ SV +A A+ L +
Sbjct: 118 AICRKQRTLPSLDIMVWSELPPGAGLGSSAAYSVCVAAALLTACEEVTNPLKDRGSIGSW 177
Query: 176 SENDKHIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLDDFP 235
E D +N+WA+ GE+ IHG PSG+DN+V+T+G AL +++ L P
Sbjct: 178 PEEDLKSINKWAYEGERVIHGNPSGVDNSVSTWGGALRYQQG---------KMSSLKRLP 228
Query: 236 AIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSKCKG 295
A+ ++LT T++PRSTK LVA VR + KFPE+M P+L ++ +L+ ++ ++
Sbjct: 229 ALQILLTNTKVPRSTKALVAGVRSRLI-KFPEIMAPLLTSIDAISLECERVLGEM----- 282
Query: 296 TDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGAGGG 355
A E Y L EL+ +N L ++GV H L+ + ++ +KLTGAGGG
Sbjct: 283 ----AAAPVPEQYLVLEELMDMNQHHLNALGVGHASLDQLCQVTAAHG-LHSKLTGAGGG 337
Query: 356 GCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLNKDLK 409
GC +TLL+ + + ++++ K+ L ++ +ET +G G + SA ++ ++
Sbjct: 338 GCGITLLKPGLERAKVEAAKQALTG-CGFDCWETSIGAPGVSMHSATSIEDPVR 390
>gb|AAX46713.1| mevalonate kinase [Bos taurus]
Length = 440
Score = 305 bits (782), Expect = 3e-81, Method: Composition-based stats.
Identities = 124/406 (30%), Positives = 207/406 (50%), Gaps = 36/406 (8%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFN 60
+S L SAPGKVI+ GEH+ V+ K A+A +++ LRT+L + + + L+ P+I
Sbjct: 2 LSEALLVSAPGKVILHGEHAVVHGKVALAMALN-LRTFLRLQP-HSNGRVGLNLPNIGVR 59
Query: 61 HKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLY 120
W + + + A +E+ + + A FLY
Sbjct: 60 RAWDVASLQLLDTSFLGHGDSAALTAKHVEKLKEVAGFPKDCVDP-----EHLAVLAFLY 114
Query: 121 MFVCLCPH---AKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGG-----LIGSNDL 172
+++ +C ++ ++ S LP GAGLGSSA+ SV LA A+ L
Sbjct: 115 LYLSICQSQRALPSLDITVWSELPTGAGLGSSAAYSVCLAAALLTACEEIPNPLKDGEAA 174
Query: 173 EKLSENDKHIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLD 232
+ +E + ++N+WAF GE+ IHG PSG+DNAV+T+G AL +++ L
Sbjct: 175 GRWTEENLELINKWAFQGERVIHGNPSGVDNAVSTWGGALRYQQG---------KISSLK 225
Query: 233 DFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSK 292
P + ++L T++PRSTK LVA VR + KFPE++ P+L ++ +L+ ++ ++
Sbjct: 226 RPPVLKILLINTKVPRSTKVLVANVRSRLL-KFPEIVAPLLTSIDAISLECERVLGEM-- 282
Query: 293 CKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGA 352
A E Y L ELI +N L ++GV H L+ + ++ +KLTGA
Sbjct: 283 -------AAAPTPEHYLTLEELIDMNQHHLNALGVGHASLDQLCQVTTAHG-LHSKLTGA 334
Query: 353 GGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCL 398
GGGGC +TLLR D+ + ++++ K+ L + ++ +ET +G G +
Sbjct: 335 GGGGCGITLLRPDVERPEVEATKRALSG-YGFDCWETSVGAPGVSV 379
>ref|XP_790690.1| PREDICTED: similar to Mevalonate kinase (MK) [Strongylocentrotus
purpuratus]
ref|XP_001200159.1| PREDICTED: similar to Mevalonate kinase (MK) [Strongylocentrotus
purpuratus]
Length = 413
Score = 305 bits (780), Expect = 7e-81, Method: Composition-based stats.
Identities = 130/407 (31%), Positives = 201/407 (49%), Gaps = 34/407 (8%)
Query: 4 PFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFNHKW 63
SAPGK+I+ GEH+ V+ K A+AA ++ LR+YL + E + L+ PDI W
Sbjct: 15 SIFISAPGKIILHGEHAVVHGKTALAAGLN-LRSYLCLKEK-DSGRLHLNLPDIDLERSW 72
Query: 64 SINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQ-LSESFHYHAAFCFLYMF 122
+ + D +NS + E++ L L +E+ A FLY++
Sbjct: 73 DVLELQEQFRDLLNSDVMEVKPSV------EIMQRLRLFLGYSDTETTKRLAVMAFLYLY 126
Query: 123 VCLCPHAKNI---KFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLIGSNDLEK----L 175
+C+ + S LP GAGLGSSA+ SV LA + I L
Sbjct: 127 LCIAGRNGKFPILDTLVSSALPPGAGLGSSAAFSVCLAAGLLTWAKAIIPLSLSDNTLDW 186
Query: 176 SENDKHIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLDDFP 235
S D ++N WA+ GE+ IHG PSGIDN+++ +G A+ + + L++ P
Sbjct: 187 SREDMELINTWAYEGERVIHGNPSGIDNSISVHGGAIEYRQK---------VITPLENMP 237
Query: 236 AIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSKCKG 295
+ ++L T + RSTK+LVA V+ +K+P+V PILD++ E + + + L +
Sbjct: 238 ELSILLVNTCVARSTKELVAGVQRRH-DKYPKVYGPILDSIEEISQECKRTLQALKTGES 296
Query: 296 TDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGAGGG 355
D + ++ L EL+ IN LL IGVSHP + I + +I KLTGAGGG
Sbjct: 297 LDK------DGAFKSLGELVDINQQLLYVIGVSHPAINNIVRSAAAYKI-HAKLTGAGGG 349
Query: 356 GCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAK 402
GC LL DI ++ + + + L +YE++ T LG G + +K
Sbjct: 350 GCVFALLPPDIPKDSVKALQADLFRH-NYESWITSLGAHGVMMHRSK 395
>ref|NP_076045.1| mevalonate kinase [Mus musculus]
sp|Q9R008|KIME_MOUSE Mevalonate kinase (MK)
gb|AAF00700.1|AF137598_1 mevalonate kinase [Mus musculus]
gb|AAH05606.1| Mevalonate kinase [Mus musculus]
Length = 395
Score = 305 bits (780), Expect = 7e-81, Method: Composition-based stats.
Identities = 125/414 (30%), Positives = 204/414 (49%), Gaps = 30/414 (7%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFN 60
+S L SAPGKVI+ GEH+ V+ K A+AA+++ LRT+LL+ + + ++ P+I
Sbjct: 2 LSEALLVSAPGKVILHGEHAVVHGKVALAAALN-LRTFLLLRP-QSNGKVSVNLPNIGIK 59
Query: 61 HKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLY 120
W + + + ++ +++ L +E A
Sbjct: 60 QVWDVGMLQRLDTSFLEQGDVSVPTLEQLEKLKKMGDLPRD--RAGNEGMALLAFLYLYL 117
Query: 121 MFVCLCPHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGG-----LIGSNDLEKL 175
++ + S LP GAGLGSSA+ SV LA A+ L + +
Sbjct: 118 AICRKQRTLPSLDMVVWSELPPGAGLGSSAAYSVCLAAALLTACEEVSNPLKDGVSVSRW 177
Query: 176 SENDKHIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLDDFP 235
E D +N+WAF GE+ IHG PSG+DNAV+T+G AL F++ L P
Sbjct: 178 PEEDLKSINKWAFEGERVIHGNPSGVDNAVSTWGGALRFQQG---------TMSSLKSLP 228
Query: 236 AIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSKCKG 295
++ ++LT T++PRSTK LVA VR +T KFPE++ P+L ++ +L+ ++ ++
Sbjct: 229 SLQILLTNTKVPRSTKALVAAVRSRLT-KFPEIVAPLLTSIDAISLECERVLGEM----- 282
Query: 296 TDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGAGGG 355
E Y L ELI +N L ++GV H L+ + ++ +KLTGAGGG
Sbjct: 283 ----VAAPVPEQYLVLEELIDMNQHHLNALGVGHNSLDQLCQVTAAHG-LHSKLTGAGGG 337
Query: 356 GCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLNKDLK 409
GC +TLL+ + Q +++ K+ L ++ +ET +G G SA + ++
Sbjct: 338 GCGITLLKPGLEQATVEAAKQALT-SCGFDCWETSIGAPGVSTHSAAAVGDPVR 390
>ref|XP_001364115.1| PREDICTED: similar to mevalonate kinase [Monodelphis domestica]
Length = 396
Score = 300 bits (769), Expect = 1e-79, Method: Composition-based stats.
Identities = 131/414 (31%), Positives = 211/414 (50%), Gaps = 32/414 (7%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFN 60
+ L SAPGKVI+ GEH+ V+ K A+A +++ LRT+L + + L P++ +
Sbjct: 2 LPETLLVSAPGKVILHGEHAVVHGKVALAEALN-LRTFLRMRP-HKDGKVRLVLPNLETS 59
Query: 61 HKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLY 120
+W ++ + ++S + + + AF +LY
Sbjct: 60 REWDVSKLQLLHASFLDSGEPTAPTTEQVEKLKAFAGFMTGSSE---RECLAVLAFLYLY 116
Query: 121 MFVCLCP-HAKNIKFSLKSTLPIGAGLGSSASISVSLALAMA-----YLGGLIGSNDLEK 174
+F+C ++ + S LP GAGLGSSA+ SV LA A+ + L +
Sbjct: 117 LFICRKHRPLPSMDIVVWSELPTGAGLGSSAAYSVCLAAALLASCEEIMNRLKEGATSAR 176
Query: 175 LSENDKHIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLDDF 234
+E++ +++N+WAF+GEK IHG PSG+DN+V+T+G AL F+K N L
Sbjct: 177 WNEDELNLINRWAFLGEKVIHGNPSGVDNSVSTWGGALRFQKG---------NISSLQRI 227
Query: 235 PAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSKCK 294
P + ++LT T++PRSTK LVA V+ + KFPE+M P+L ++ + + ++ +
Sbjct: 228 PVLKILLTNTKVPRSTKALVASVKDRL-AKFPEIMNPLLVSIDAISQECERVLGVM---- 282
Query: 295 GTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGAGG 354
A E Y L ELI +N L +IGV H L+ + ++ +KLTGAGG
Sbjct: 283 -----AATPTPEQYMVLEELIDMNQHHLNAIGVGHSSLDRLCQVTAAHG-LHSKLTGAGG 336
Query: 355 GGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLNKDL 408
GGC TLLR + Q +++ K+ L +E +ET +GG G L S +L ++
Sbjct: 337 GGCGFTLLRPGLDQSVVEAIKQALT-SCGFECWETTIGGPGVSLHSEASLKANV 389
>ref|XP_001496887.1| PREDICTED: similar to mevalonate kinase [Equus caballus]
Length = 407
Score = 300 bits (767), Expect = 2e-79, Method: Composition-based stats.
Identities = 127/414 (30%), Positives = 210/414 (50%), Gaps = 31/414 (7%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFN 60
+S L SAPGKVI+ GEH+ V+ K A+A +++ LRT+L + + + L+ P+I
Sbjct: 12 LSEVLLVSAPGKVILHGEHAVVHGKVALAVALN-LRTFLRLQP-HSTGKVGLNLPNIGIK 69
Query: 61 HKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLY 120
W + + + + +E+ + + AF FLY
Sbjct: 70 QAWDVASLQLLDTSFLEQGDITALTPEQVEKLKEVAGCPED--CANDHKWLAVLAFLFLY 127
Query: 121 MFVCLCPHA-KNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGG-----LIGSNDLEK 174
+ +C A ++ ++ S LP GAGLGSSA+ SV LA A L +
Sbjct: 128 LSICRKQRALPSLDVTVWSELPPGAGLGSSAAYSVCLAAAFLAACEEIPNPLKDGEPTSR 187
Query: 175 LSENDKHIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLDDF 234
+E D ++N+WAF GE+ IHG PSG+DN V+T+G AL +++ L
Sbjct: 188 WTEEDLELINKWAFQGERVIHGNPSGVDNTVSTWGGALRYQQG---------KISSLKRP 238
Query: 235 PAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSKCK 294
PA+ ++LT T++PRSTK LVA VR + KFPE++ P+L ++ +L+ ++ ++
Sbjct: 239 PALKILLTNTKVPRSTKALVAGVRNRLL-KFPEIVAPVLTSIEAISLECERVLAEM---- 293
Query: 295 GTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGAGG 354
A Y L ELI +N L ++GV H L+ + ++ +KLTG GG
Sbjct: 294 -----ASAPTPGHYLVLEELIDMNQHHLNALGVGHASLDQLCQVTTAHG-LHSKLTGGGG 347
Query: 355 GGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLNKDL 408
GGC +TLLR D+ + ++++ K+ L ++ +ET +G G + +A +L+ +
Sbjct: 348 GGCGITLLRPDLQRLEVEAAKQALTG-CGFDCWETSIGAPGVSVHAATSLDAPI 400
>dbj|BAE28997.1| unnamed protein product [Mus musculus]
Length = 407
Score = 298 bits (764), Expect = 5e-79, Method: Composition-based stats.
Identities = 127/424 (29%), Positives = 205/424 (48%), Gaps = 38/424 (8%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFN 60
+S L SAPGKVI+ GEH+ V+ K A+AA+++ LRT+LL+ + + ++ P+I
Sbjct: 2 LSEALLVSAPGKVILHGEHAVVHGKVALAAALN-LRTFLLLRP-QSNGKVSVNLPNIGIK 59
Query: 61 HKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLD----------PLLAQLSESF 110
W + + + + T+ + +L P +E
Sbjct: 60 QVWDVGMLQRLDTSFLGLSPTCLFARVTEQGDVSVPTLEQLEKLKKMGDLPRDRAGNEGM 119
Query: 111 HYHAAFCFLYMFVCLCPHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGG----- 165
A ++ + S LP GAGLGSSA+ SV LA A+
Sbjct: 120 ALLAFLYLYLAICRKQRTLPSLDMVVWSELPPGAGLGSSAAYSVCLAAALLTACEEVSNP 179
Query: 166 LIGSNDLEKLSENDKHIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINT 225
L + + E D +N+WAF GE+ IHG PSG+DNAV+T+G AL F++
Sbjct: 180 LKDGVSVSRWPEEDLKSINKWAFEGERVIHGNPSGVDNAVSTWGGALRFQQG-------- 231
Query: 226 NNFKFLDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLE 285
L P++ ++LT T++PRSTK LVA VR +T KFPE++ P+L ++ +L+
Sbjct: 232 -TMSSLKSLPSLQILLTNTKVPRSTKALVAAVRSRLT-KFPEIVAPLLTSIDAISLECER 289
Query: 286 IMTKLSKCKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIG 345
++ ++ E Y L ELI +N L ++GV H L+ + ++
Sbjct: 290 VLGEM---------VAAPVPEQYLVLEELIDMNQHHLNALGVGHNSLDQLCQVTAAHG-L 339
Query: 346 STKLTGAGGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLN 405
+KLTGAGGGGC +TLL+ + Q +++ K+ L ++ +ET +G G SA +
Sbjct: 340 HSKLTGAGGGGCGITLLKPGLEQATVEAAKQALT-SCGFDCWETSIGAPGVSTHSAAAVG 398
Query: 406 KDLK 409
++
Sbjct: 399 DPVR 402
>ref|XP_001628178.1| predicted protein [Nematostella vectensis]
gb|EDO36115.1| predicted protein [Nematostella vectensis]
Length = 415
Score = 296 bits (759), Expect = 2e-78, Method: Composition-based stats.
Identities = 136/431 (31%), Positives = 212/431 (49%), Gaps = 44/431 (10%)
Query: 1 MSLP-FLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISF 59
M L + SAPGK+I+ GEH+ VY K A+A S+ LRT +++ + L D+ +
Sbjct: 1 MKLSRVVVSAPGKIILHGEHAVVYGKAAIAVSI-GLRTTVVLQRHKNESKVSLLLKDLDY 59
Query: 60 NHKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQ---LSESFHYHAAF 116
W + D I V ++++ E++SL+D L+ + AA
Sbjct: 60 ILTWDLTDIQKIL---VAVPQVSRTDTVLPS--DEMLSLIDKLIDSSKFVEVEGVKDAAR 114
Query: 117 CFLYMF---VCLCPHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLI------ 167
FL++ + I+ +K+ LP+GAGLGSSA+ S+SLA AM I
Sbjct: 115 VFLFLMTSTLRDRDRLPAIEVEVKTALPLGAGLGSSAAYSISLAAAMLLSMQTIPLPKYV 174
Query: 168 -------------GSNDLEKLSENDKHIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLF 214
S + + +V QWAF EK +HG PSGIDN++ATYG ALLF
Sbjct: 175 KKTPESETTAKDTDSYQYDDIETESLRLVCQWAFEAEKIMHGQPSGIDNSIATYGGALLF 234
Query: 215 EKDSHNGTINTNNFKFLDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILD 274
+ L+ P + ++L T+IPRST+ +VA VR E FP V + +
Sbjct: 235 QNGE---------ITHLESMPLLSILLIDTQIPRSTRVMVAGVRDRYIE-FPTVYMSLFE 284
Query: 275 AMGECALQGLEIMTKLSKCKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLEL 334
A+ + ++I +K+ K D E Y++L L+ +N LL GVSHP L+
Sbjct: 285 AVDGICHECIKIFSKIHNLKNEDVPKSEFVR-YYQRLESLVDVNQQLLSLFGVSHPSLDS 343
Query: 335 IKNLSDDLRIGSTKLTGAGGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGT 394
+ +++ TKLTGAGGGGC++TL+ ++++ KLQ +F Y+ ++T LG
Sbjct: 344 LCHMTSKYG-LHTKLTGAGGGGCAITLIPPGTDKDKVAELMNKLQKEFKYKVWQTPLGSR 402
Query: 395 GCCLLSAKNLN 405
G + A ++
Sbjct: 403 GVIVHEAIPVD 413
>ref|XP_500956.1| hypothetical protein [Yarrowia lipolytica]
emb|CAG83209.1| unnamed protein product [Yarrowia lipolytica CLIB122]
Length = 449
Score = 295 bits (755), Expect = 5e-78, Method: Composition-based stats.
Identities = 161/430 (37%), Positives = 237/430 (55%), Gaps = 44/430 (10%)
Query: 3 LPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLIS-ESSAPDTIELDFPDISFNH 61
+ ++ SAPGKVI+FGEH+AV+ KPA+AA++ LRTYLL+ +S T+ L+FPDI N
Sbjct: 1 MDYIISAPGKVILFGEHAAVFGKPAIAAAID-LRTYLLVETTTSDTPTVTLEFPDIHLNF 59
Query: 62 KWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLYM 121
K ++ ++T + D + +S L L A FLY+
Sbjct: 60 KVQVDKLASLTAQTKADHLNWSTPKTLDKHIFDSLSSLALLEEPGLTKVQQAAVVSFLYL 119
Query: 122 FVCLCPHA---KNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLIG---SNDLEKL 175
++ LCP + + + ++STLPIGAGLGSSASI V LA + L G + + D + L
Sbjct: 120 YIHLCPPSVCEDSSNWVVRSTLPIGAGLGSSASICVCLAAGLLVLNGQLSIDQARDFKSL 179
Query: 176 SENDKHIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLDDFP 235
+E +V+ W+F+GE CIHG PSGIDNAVAT G ALLF++ NN L D P
Sbjct: 180 TEKQLSLVDDWSFVGEMCIHGNPSGIDNAVATQGGALLFQR--------PNNRVPLVDIP 231
Query: 236 AIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSK--- 292
+ ++LT T+ PRST DLV V VL E F +M PI+ ++GE + Q +EI+++ K
Sbjct: 232 EMKLLLTNTKHPRSTADLVGGVGVLTKE-FGSIMDPIMTSVGEISNQAMEIISRGKKMVD 290
Query: 293 --------------------CKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGL 332
D ++ ++ ++ L+RINHGLL+++GVSHP L
Sbjct: 291 QSNLEIEQGILPQPTSEDACNVMEDGATLQKLRDIGSEMQHLVRINHGLLIAMGVSHPKL 350
Query: 333 ELIKNLSDDLRIGSTKLTGAGGGGCSLTLL-RRDITQEQIDSFKKKLQDD---FSYETFE 388
E+I+ S +G TKLTGAGGGGC++TL+ +D T Q++ ++ +E E
Sbjct: 351 EIIRTASIVHNLGETKLTGAGGGGCAITLVTSKDKTATQLEENVIAFTEEMATHGFEVHE 410
Query: 389 TDLGGTGCCL 398
T +G G +
Sbjct: 411 TTIGARGVGM 420
>ref|NP_592837.1| mevalonate kinase Erg12 (predicted) [Schizosaccharomyces pombe
972h-]
sp|Q09780|KIME_SCHPO Putative mevalonate kinase (MK)
emb|CAA91104.1| mevalonate kinase Erg12 (predicted) [Schizosaccharomyces pombe]
dbj|BAA25169.1| putative mevalonate kinase [Schizosaccharomyces pombe]
Length = 404
Score = 287 bits (734), Expect = 1e-75, Method: Composition-based stats.
Identities = 130/401 (32%), Positives = 201/401 (50%), Gaps = 27/401 (6%)
Query: 1 MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFN 60
MS + S+PGK I+FGEH+ VY A+AA+VS LR+Y + ++ + I + DI
Sbjct: 1 MSKSLIVSSPGKTILFGEHAVVYGATALAAAVS-LRSYCKLQTTNNNE-IVIVMSDIGTE 58
Query: 61 HKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLY 120
+W++ + Q + +L+ L LL + A C LY
Sbjct: 59 RRWNLQSLPWQHVT------VENVQHPASSPNLDLLQGLGELLKNEENGLIHSAMLCTLY 112
Query: 121 MFVCLCPHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLIGSNDLEKLSEND- 179
+F L ++ ++ S +P+GAGLGSSA+ISV +A ++ G I L N
Sbjct: 113 LFTSLSSPSQGCTLTISSQVPLGAGLGSSATISVVVATSLLLAFGNIEPPSSNSLQNNKA 172
Query: 180 KHIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLDDFPAIPM 239
++ W+F+GE CIHGTPSGIDNAVAT G + F K + +FL + +
Sbjct: 173 LALIEAWSFLGECCIHGTPSGIDNAVATNGGLIAFRK---ATAHQSAMKEFLKPKDTLSV 229
Query: 240 ILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSKCKGTDDE 299
++T T+ P+STK LV V L E+ P V+ I+DA+ + + +T S
Sbjct: 230 MITDTKQPKSTKKLVQGVFEL-KERLPTVIDSIIDAIDGISKSAVLALTSES-------- 280
Query: 300 AVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGAGGGGCSL 359
N ++L E I +N LL +GVSH ++ + + IG TKLTGAGGGGC++
Sbjct: 281 ---DKNSSAKKLGEFIVLNQKLLECLGVSHYSIDRVLQATKS--IGWTKLTGAGGGGCTI 335
Query: 360 TLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLS 400
TLL + +E+ K+ L + ++ LGG G +++
Sbjct: 336 TLLTPECKEEEFKLCKESLLAHKN-SIYDVQLGGPGVSVVT 375
>ref|XP_001540400.1| conserved hypothetical protein [Ajellomyces capsulatus NAm1]
gb|EDN07730.1| conserved hypothetical protein [Ajellomyces capsulatus NAm1]
Length = 411
Score = 284 bits (726), Expect = 1e-74, Method: Composition-based stats.
Identities = 130/363 (35%), Positives = 193/363 (53%), Gaps = 26/363 (7%)
Query: 48 DTIELDFPDISFNHKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLS 107
TI L+F DI +H W I+ + +K + L EL+ + P +A +S
Sbjct: 8 RTITLNFRDIELDHTWDIDSLPWELFHHPSKKKFYYSS--VTSLDTELLEAIQPHIADIS 65
Query: 108 -------ESFHYHAAFCFLYMFVCLC-PHAKNIKFSLKSTLPIGAGLGSSASISVSLALA 159
H +A FLY+F+ L P ++L+ST+PIGAGLGSSASI+V L+ A
Sbjct: 66 IGKPDEVRKIHQSSATAFLYLFLSLSSPQTHAAVYTLRSTIPIGAGLGSSASIAVCLSAA 125
Query: 160 MAYLGGLIGSNDLEKLSENDK---HIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEK 216
+ ++ ++L E + +N+WAF+GE CIHG PSG+DN V+ G A++F +
Sbjct: 126 LLLQIRILAGPHQDQLPEEAETQIERINKWAFVGEMCIHGNPSGVDNTVSAGGKAVIFRR 185
Query: 217 DSHNGTINTNNFKFLDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAM 276
++ + + DFP +P++L +R PRST VA+V + P V + IL+A+
Sbjct: 186 GDYS---KPPSVTPILDFPELPLLLVNSRQPRSTSVEVAKVAN-FCKAHPAVSESILEAI 241
Query: 277 GECALQGLEIMTKLSKCKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIK 336
+ ++++E + EL RINHGLLVS+GVSHP LE I+
Sbjct: 242 DQVTESA--------SNLIQSGRFDKSSSEAIDHFGELFRINHGLLVSLGVSHPRLERIR 293
Query: 337 NLSDDLRIGSTKLTGAGGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGC 396
L D G TKLTGAGGGGC++TLLR + + +K L D+ +E +ET LGG G
Sbjct: 294 ELVDHTGSGWTKLTGAGGGGCAITLLRTNTDPAALKRLEKTLDDE-GFERYETILGGHGI 352
Query: 397 CLL 399
+L
Sbjct: 353 GVL 355
>gb|EDU45497.1| mevalonate kinase [Pyrenophora tritici-repentis Pt-1C-BFP]
Length = 499
Score = 283 bits (723), Expect = 3e-74, Method: Composition-based stats.
Identities = 137/412 (33%), Positives = 207/412 (50%), Gaps = 62/412 (15%)
Query: 35 LRTYLLISE-SSAPDTIELDFPDISFNHKWSINDFNAITEDQVNSQKLAKAQQATDGLSQ 93
LR+YL +S S + T++L FPDI H W I+ + Q +K L
Sbjct: 40 LRSYLHVSFLSKSNRTVKLRFPDIQMEHTWDIDQLPWDSFTQPGKKKYY--YDLVTSLDP 97
Query: 94 ELVSLLDPLLAQLS-------ESFHYHAAFCFLYMFVCL-CPHAKNIKFSLKSTLPIGAG 145
+L++ + P + ++S H+ +A+ FLY+F+ L ++L+ST+PIGAG
Sbjct: 98 DLMAAIKPFIDEVSAKAPEHIRKIHHASAYSFLYLFMSLASRKVPPCVYTLRSTIPIGAG 157
Query: 146 LGSSASISVSLALAMA-YLGGLIGSNDLEKLSENDK--HIVNQWAFIGEKCIHGTPSGID 202
LGSSASISV ++ A+ + L G + + E + +N+WAF+GE CIHG PSG+D
Sbjct: 158 LGSSASISVCISTALLLQIRALSGPHQDQPPQECELNIERINRWAFVGEMCIHGNPSGVD 217
Query: 203 NAVATYGNALLFEKDSHNGTINTNNFKFLDDFPAIPMILTYTRIPRSTKDLVARVRVLVT 262
N V++ G A+LF++ + L FP +P++L TR RST VA+V L
Sbjct: 218 NTVSSGGKAVLFQRRDY---DKPPLVVPLHSFPELPLLLVNTRQSRSTATEVAKVAHL-R 273
Query: 263 EKFPEVMKPILDAMGECALQGLEIMTKLSKCKGTDDEAVETNNELYEQLLELIRINHGLL 322
P + + IL+A+G +++T + T+ + L EL+ INHGLL
Sbjct: 274 NVHPALTENILNAIGLVTESAHKLLTSP--------DFDATSPAALKHLGELVTINHGLL 325
Query: 323 VSIGVSHPGLELIKNLSDDLRIGSTKLTGAGGGGCSLTLLRRDITQ-------------- 368
VS+GVSHP LE I+ + D IG TKLTGAGGGGC++T+L+
Sbjct: 326 VSLGVSHPKLERIREIIDHTGIGWTKLTGAGGGGCAITILKPQPPALTNGHSHDEPSSDE 385
Query: 369 ---------------------EQIDSFKKKLQDDFSYETFETDLGGTGCCLL 399
+ +DS + KL+ + +E FET L G G +L
Sbjct: 386 SSEADVDCGSSVISNGTKLKYKILDSLEVKLEQE-GFEKFETTLAGDGVGVL 436
>gb|AAD45421.1|L77688_1 mevalonate kinase [Arabidopsis thaliana]
Length = 376
Score = 281 bits (720), Expect = 5e-74, Method: Composition-based stats.
Identities = 113/399 (28%), Positives = 185/399 (46%), Gaps = 28/399 (7%)
Query: 3 LPFLTSAPGKVIIFGEHSAVYNKPAVAASVSAL-RTYLLISESSAPDTIELDFPDISFNH 61
+ APGK+I+ GEH+ V+ AVAA++ L S D + L DIS
Sbjct: 1 MEVKARAPGKIILAGEHAVVHGSTAVAAAIDLYTYVTLRFPLPSNNDRLTLQLKDISLEF 60
Query: 62 KWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLYM 121
WS+ ++ + ++ + + L++ + + FL++
Sbjct: 61 SWSLARIKEAIPYDSSTLCRSTPASCSEETLKSIAVLVEEQNLPKEKMWLSSGISTFLWL 120
Query: 122 FVCLCPHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMA--YLGGLIGSNDLEKLSEND 179
+ + + S LP G+GLGSSA++ V+L A+ + N L E +
Sbjct: 121 YTRIIGFNP-ATVVINSELPYGSGLGSSAALCVALTAALLASSISEKTRGNGWSSLDETN 179
Query: 180 KHIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLDDFPAIPM 239
++N+WAF GEK IHG PSGIDN V+ YGN + F L + M
Sbjct: 180 LELLNKWAFEGEKIIHGKPSGIDNTVSAYGNMIKFCSGE---------ITRLQSNMPLRM 230
Query: 240 ILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSKCKGTDDE 299
++T TR+ R+TK LV+ V + P+ MK + +A+ + + I+ + T+ E
Sbjct: 231 LITNTRVGRNTKALVSGVSQRAV-RHPDAMKSVFNAVDSISKELAAIIQSKDETSVTEKE 289
Query: 300 AVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGAGGGGCSL 359
E++ EL+ +N GLL+S+GVSH +E + + + +KLTGAGGGGC L
Sbjct: 290 ---------ERIKELMEMNQGLLLSMGVSHSSIEAVILTTVKHK-LVSKLTGAGGGGCVL 339
Query: 360 TLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCL 398
TLL +D ++L+ ++ F +GG G +
Sbjct: 340 TLLPTG---TVVDKVVEELESS-GFQCFTALIGGNGAQI 374
Database: All non-redundant GenBank CDS
translations+PDB+SwissProt+PIR+PRF excluding environmental samples
from WGS projects
Posted date: May 23, 2008 5:56 PM
Number of letters in database: 883,778,997
Number of sequences in database: 2,617,685
Database: /host/Blast/data/nr_perl/nr.01
Posted date: May 23, 2008 5:54 PM
Number of letters in database: 976,759,346
Number of sequences in database: 2,761,413
Database: /host/Blast/data/nr_perl/nr.02
Posted date: May 23, 2008 5:48 PM
Number of letters in database: 374,670,760
Number of sequences in database: 1,165,270
Database: /host/Blast/data/nr_perl/nr.03
Posted date: Apr 28, 2009 5:40 PM
Number of letters in database: 114,943,120
Number of sequences in database: 354,819
Lambda K H
0.312 0.138 0.349
Lambda K H
0.267 0.0425 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 5,225,860,772
Number of Sequences: 6899187
Number of extensions: 201479504
Number of successful extensions: 778016
Number of sequences better than 10.0: 300
Number of HSP's better than 10.0 without gapping: 4086
Number of HSP's successfully gapped in prelim test: 2005
Number of HSP's that attempted gapping in prelim test: 761454
Number of HSP's gapped (non-prelim): 9005
length of query: 443
length of database: 2,350,152,223
effective HSP length: 137
effective length of query: 306
effective length of database: 1,404,963,604
effective search space: 429918862824
effective search space used: 429918862824
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.3 bits)
S2: 80 (35.4 bits)