Gene : PXA1

Symbol :	PXA1
Name/description :	PXA1 (PEROXISOMAL ABC TRANSPORTER 1); ATPase, coupled to transmembrane movement of substances
Synonyms :	COMATOSE, CTS, PED3, PEROXISOMAL ABC TRANSPORTER 1, PEROXISOME DEFECTIVE 3, PXA1, T5J17.20, T5J17_20
Organism :	Arabidopsis thaliana
Peroxisomal Localization :	GO: peroxisome Steven Footitt, et al.2002. EMBO J. GFP: No experiment found Mass Spectrometry: Holger Eubel, et al.2008. Plant Physiol. PeroxisomeDB annotation
Protein family :	ABCD
Protein consensus sequence :	MPSLQLLQLTERGRGLVASRRKSILLAAGIVAAGGTAVYLKSRVASRRPDSSRLCNGQSDDDETLEKLTATDQNAKITTKKKKGGGLKSLQVLTAILLSQMGKMGARDLLALVATVVFRTALSNRLAKVQGFLFRAAFLRRAPLFLRLISENIMLCFMLSTLHSTSKYITGALSLRFRKILTKIIHSHYFENMVYYKISHVDGRITHPEQRIASDVPRFSSELSDLILDDLTAVTDGILYAWRLCSYASPKYIFWILAYVLGAGTAIRNFSPSFGKLMSKEQQLEGEYRQLHSRLRTHSESIAFYGGETREESHIQQKFKNLVSHMSHVLHDHWWFGMIQDFLLKYLGATVAVILIIEPFFSGHLRPDDSTLGRAEMLSNIRYHTSVIISLFQALGTLSISSRRLNRLSGYADRIHELMAVSRELSGDDKSSFQRNRSRNYLSEANYVEFSDVKVVTPTGNVLVEDLTLRVEQGSNLLITGPNGSGKSSLFRVLGGLWPLVSGHIVKPGVGSDLNKEIFYVPQRPYMAVGTLRDQLIYPLTSGQESELLTEIGMVELLKNVDLEYLLDRYQPEKEVNWGDELSLGEQQRLGMARLFYHKPKFAILDECTSAVTTDMEERFAAKVRAMGTSCITISHRPALVAFHDVVLSLDGEGGWSVHYKRDDSALLTDAEIDSVKSSDTDRQNDAMVVQRAFAAARKESATNSKAQSYQTQLIARSPVVDKSVVLPRFPQPQTSQRALPSRVAAMLNVLIPTIFDKQGAQLLAVACLVVSRTLISDRIASLNGTTVKYVLEQDKAAFVRLIGLSVLQSGASSIIAPSLRHLTQRLALGWRIRLTQHLLRNYLRNNAFYKVFHMSGNSIDADQRLTRDLEKLTADLSGLLTGMVKPSVDILWFTWRMKLLTGQRGVAILYTYMLLGLGFLRRVAPDFGDLAGEEQQLEGKFRFMHERLNTHAESIAFFGGGAREKAMVDKKFRALLDHSLMLLRKKWLYGILDDFVTKQLPNNVTWGLSLLYALEHKGDRALVSTQGELAHALRYLASVVSQSFMAFGDILELHKKFLELSGGINRIFELDEFLDASQSGVTSENQTSRLDSQDLLSFSEVDIITPAQKLMASKLSCEIVSGKSLLVTGPNGSGKTSVFRVLRDIWPTVCGRLTKPSLDIKELGSGNGMFFVPQRPYTCLGTLRDQIIYPLSKEEAEKRAAKLYTSGESSTEAGSILDSHLKTILENVRLVYLLERDVGGWDATTNWEDILSLGEQQRLGMARLFFHRPKFGVLDECTNATSVDVEEQLYRVARDMGVTFITSSQRPALIPFHSLELRLIDGEGNWELRSIEQTTE
Functional category(ies) :	ABC transporters Fatty acid oxidation Fatty acid synthesis/PUFAS synthesis Lipid metabolism Peroxisomal membrane proteins (PMP) Straight chain fatty acids oxidation
Disease(s) :	No diseases found
Comparative genomics:	PTS prediction Blastp PsiBlast Alignment Phylogenetic tree [help]
Gene Info:	Gene Summary (NCBI) Chromosomal Localization (NCBI) Conserved Domains (NCBI) Orthologue Prediction (NCBI)
Pubmed:	Daniela Dietrich, et al.2009. Mol. Biol. Cell Mutations in the Arabidopsis peroxisomal ABC transporter COMATOSE allow differentiation between multiple functions in planta: insights from an allelic series. Rea Rea, et al.2007. Plant ATP-binding cassette transporters. Helen Pinfield-Wells, et al.2005. Plant J. Sucrose rescues seedling establishment but not germination of Arabidopsis mutants disrupted in peroxisomal fatty acid catabolism. Martin Fulda, et al.2004. Plant Cell Peroxisomal Acyl-CoA synthetase activity is essential for seedling development in Arabidopsis thaliana. Steven Footitt, et al.2002. EMBO J. Control of germination and lipid mobilization by COMATOSE, the Arabidopsis homologue of human ALDP.