Gene : MLYCD

Symbol :	MLYCD
Name/description :	malonyl-CoA decarboxylase
Synonyms :	MCD, MGC59795
Organism :	Homo sapiens
Peroxisomal Localization :	GO: peroxisome R Sacksteder, et al.1999. J. Biol. Chem. GFP: No experiment found Mass Spectrometry: No experiment found PeroxisomeDB annotation
Protein family :	MLYCD
Protein consensus sequence :	PTS1=0.0025; start position=482; end position=493; MRGFGPGLTARRLLPLRLPPRPPGPRLASGQAAGALERAMDELLRRAVPPTPAYELREKTPAPAEGQCADFVSFYGGLAETAQRAELLGRLARGFGVDHGQVAEQSAGVLHLRQQQREAAVLLQAEDRLRYALVPRYRGLFHHISKLDGGVRFLVQLRADLLEAQALKLVEGPDVREMNGVLKGMLSEWFSSGFLNLERVTWHSPCEVLQKISEAEAVHPVKNWMDMKRRVGPYRRCYFFSHCSTPGEPLVVLHVALTGDISSNIQAIVKEHPPSETEEKNKITAAIFYSISLTQQGLQGVELGTFLIKRVVKELQREFPHLGVFSSLSPIPGFTKWLLGLLNSQTKEHGRNELFTDSECKEISEITGGPINETLKLLLSSSEWVQSEKLVRALQTPLMRLCAWYLYGEKHRGYALNPVANFHLQNGAVLWRINWMADVSLRGITGSCGLMANYRYFLEETGPNSTSYLGSKIIKASEQVLSLVAQFQKNSKL
Functional category(ies) :	Fatty acid oxidation Lipid metabolism
Disease(s) :	Malonic aciduria
Comparative genomics:	PTS prediction Blastp PsiBlast Alignment Phylogenetic tree [help] PhylomeDB Enzyme reaction data
Gene Info:	Gene Summary (NCBI) Genome Browser (UCSC) Chromosomal Localization (NCBI) ENSEMBL SNPs (NCBI) Intron/Exon (Ace View: NCBI) Gene Expression (UCSC) Protein Properties (UCSC) Conserved Domains (NCBI) Orthologue Prediction (NCBI)
Pubmed:	David Saggerson, et al.2008. Annu. Rev. Nutr. Malonyl-CoA, a key signaling molecule in mammalian cells. R Wightman, et al.2003. Hum. Mutat. MLYCD mutation analysis: evidence for protein mistargeting as a cause of MLYCD deficiency. H Mulder, et al.2001. J. Biol. Chem. Overexpression of a modified human malonyl-CoA decarboxylase blocks the glucose-induced increase in malonyl-CoA level but has no impact on insulin secretion in INS-1-derived (832/13) beta-cells.