Gene : ABCD3

Symbol :	ABCD3
Name/description :	ATP-binding cassette, sub-family D, member 3
Synonyms :	ABC43, PMP70, PXMP1
Organism :	Homo sapiens
Peroxisomal Localization :	GO: peroxisome J Gärtner, et al.1992. Nat. Genet. J Gärtner, et al.1998. Genomics X Sacksteder, et al.2000. J. Cell Biol. GFP: No experiment found Mass Spectrometry: No experiment found PeroxisomeDB annotation
Protein family :	ABCD
Protein consensus sequence :	PEX19=0.019; start position=61; end position=70; MAAFSKYLTARNSSLAGAAFLLLCLLHKRRRALGLHGKKSGKPPLQNNEKEGKKERAVVDKVFFSRLIQILKIMVPRTFCKETGYLVLIAVMLVSRTYCDVWMIQNGTLIESGIIGRSRKDFKRYLLNFIAAMPLISLVNNFLKYGLNELKLCFRVRLTKYLYEEYLQAFTYYKMGNLDNRIANPDQLLTQDVEKFCNSVVDLYSNLSKPFLDIVLYIFKLTSAIGAQGPASMMAYLVVSGLFLTRLRRPIGKMTITEQKYEGEYRYVNSRLITNSEEIAFYNGNKREKQTVHSVFRKLVEHLHNFILFRFSMGFIDSIIAKYLATVVGYLVVSRPFLDLSHPRHLKSTHSELLEDYYQSGRMLLRMSQALGRIVLAGREMTRLAGFTARITELMQVLKDLNHGKYERTMVSQQEKGIEGVQVIPLIPGAGEIIIADNIIKFDHVPLATPNGDVLIRDLNFEVRSGANVLICGPNGCGKSSLFRVLGELWPLFGGRLTKPERGKLFYVPQRPYMTLGTLRDQVIYPDGREDQKRKGISDLVLKEYLDNVQLGHILEREGGWDSVQDWMDVLSGGEKQRMAMARLFYHKPQFAILDECTSAVSVDVEGYIYSHCRKVGITLFTVSHRKSLWKHHEYYLHMDGRGNYEFKQITEDTVEFGS
Functional category(ies) :	ABC transporters Di- trihydroxycholestanoic acid oxidation/Bile acid synthesis Fatty acid oxidation Fatty acid synthesis/PUFAS synthesis Lipid metabolism Peroxisomal membrane proteins (PMP) Straight chain fatty acids oxidation
Disease(s) :	No diseases found
Comparative genomics:	PTS prediction Blastp PsiBlast Alignment Phylogenetic tree [help] PhylomeDB
Gene Info:	Gene Summary (NCBI) Genome Browser (UCSC) Chromosomal Localization (NCBI) ENSEMBL SNPs (NCBI) Intron/Exon (Ace View: NCBI) Gene Expression (UCSC) Protein Properties (UCSC) Conserved Domains (NCBI) Orthologue Prediction (NCBI)
Pubmed:	M Biermanns, et al.2001. Biochem. Biophys. Res. Commun. Targeting elements in the amino-terminal part direct the human 70-kDa peroxisomal integral membrane protein (PMP70) to peroxisomes. S Braiterman, et al.1998. Hum. Mol. Genet. Suppression of peroxisomal membrane protein defects by peroxisomal ATP binding cassette (ABC) proteins. J GÃ¤rtner, et al.1998. Eur. J. Cell Biol. Restoration of PEX2 peroxisome assembly defects by overexpression of PMP70. J GÃ¤rtner, et al.1994. J. Inherit. Metab. Dis. Restoration of peroxisome biogenesis in a peroxisome-deficient mammalian cell line by expression of either the 35 kDa or the 70 kDa peroxisomal membrane proteins. J GÃ¤rtner, et al.1992. Nat. Genet. Mutations in the 70K peroxisomal membrane protein gene in Zellweger syndrome.