Gene : ABCD4

Symbol :	ABCD4
Name/description :	ATP-binding cassette, sub-family D, member 4
Synonyms :	P70R, P79R, ABC41, PMP69, PXMP1L, EST352188
Organism :	Homo sapiens
Peroxisomal Localization :	GO: No Peroxisomal annotation GFP: No experiment found Mass Spectrometry: No experiment found PeroxisomeDB annotation
Protein family :	ABCD
Protein consensus sequence :	PEX19=0.0032; start position=18; end position=27; PEX19=0.0087; start position=40; end position=49; PEX19=0.063; start position=583; end position=592; MAVAGPAPGAGARPRLDLQFLQRFLQILKVLFPSWSSQNALMFLTLLCLTLLEQFVIYQVGLIPSQYYGVLGNKDLEGFKTLTFLAVMLIVLNSTLKSFDQFTCNLLYVSWRKDLTEHLHRLYFRGRAYYTLNVLRDDIDNPDQRISQDVERFCRQLSSMASKLIISPFTLVYYTYQCFQSTGWLGPVSIFGYFILGTVVNKTLMGPIVMKLVHQEKLEGDFRFKHMQIRVNAEPAAFYRAGHVEHMRTDRRLQRLLQTQRELMSKELWLYIGINTFDYLGSILSYVVIAIPIFSGVYGDLSPAELSTLVSKNAFVCIYLISCFTQLIDLSTTLSDVAGYTHRIGQLRETLLDMSLKSQDCEILGESEWGLDTPPGWPAAEPADTAFLLERVSISAPSSDKPLIKDLSLKISEGQSLLITGNTGTGKTSLLRVLGGLWTSTRGSVQMLTDFGPHGVLFLPQKPFFTDGTLREQVIYPLKEVYPDSGSADDERILRFLELAGLSNLVARTEGLDQQVDWNWYDVLSPGEMQRLSFARLFYLQPKYAVLDEATSALTEEVESELYRIGQQLGMTFISVGHRQSLEKFHSLVLKLCGGGRWELMRIKVE
Functional category(ies) :	ABC transporters Di- trihydroxycholestanoic acid oxidation/Bile acid synthesis Fatty acid oxidation Fatty acid synthesis/PUFAS synthesis Lipid metabolism Peroxisomal membrane proteins (PMP) Straight chain fatty acids oxidation
Disease(s) :	No diseases found
Comparative genomics:	PTS prediction Blastp PsiBlast Alignment Phylogenetic tree [help] PhylomeDB
Gene Info:	Gene Summary (NCBI) Genome Browser (UCSC) Chromosomal Localization (NCBI) ENSEMBL SNPs (NCBI) Intron/Exon (Ace View: NCBI) Gene Expression (UCSC) Protein Properties (UCSC) Conserved Domains (NCBI) Orthologue Prediction (NCBI)
Pubmed:	Stephan Wanders, et al.2007. Pflugers Arch. The peroxisomal ABC transporter family. Muriel Asheuer, et al.2005. Hum. Mol. Genet. Decreased expression of ABCD4 and BG1 genes early in the pathogenesis of X-linked adrenoleukodystrophy. Kohichiroh Yasui, et al.2004. Cancer Res. Alteration in copy numbers of genes as a mechanism for acquired drug resistance. Aritoshi Iida, et al.2002. J. Hum. Genet. Catalog of 605 single-nucleotide polymorphisms (SNPs) among 13 genes encoding human ATP-binding cassette transporters: ABCA4, ABCA7, ABCA8, ABCD1, ABCD3, ABCD4, ABCE1, ABCF1, ABCG1, ABCG2, ABCG4, ABCG5, and ABCG8. A Holzinger, et al.1997. Biochem. Biophys. Res. Commun. Primary structure of human PMP69, a putative peroxisomal ABC-transporter. N Shani, et al.1997. Hum. Mol. Genet. Identification of a fourth half ABC transporter in the human peroxisomal membrane.