Gene : Pex5

Symbol :	Pex5
Name/description :	peroxisomal biogenesis factor 5
Synonyms :	Pxr1, ESTM1, PTS1R, X83306, AW212715
Organism :	Mus musculus
Peroxisomal Localization :	GO: protein targeting to peroxisome Sietske Hogenboom, et al.2002. J. Lipid Res. Anneleen Janssen, et al.2003. J. Neurosci. Ruud Dirkx, et al.2005. Hepatology GFP: No experiment found Mass Spectrometry: Sebastian Wiese, et al.2007. Mol. Cell PROTEOMICS PeroxisomeDB annotation
Protein family :	PEX5
Protein consensus sequence :	MAMRELVEGECGGANPLMKLATHFTQDKALRQEGLRPGPWPPGASAAETVSKPLGVGTEDELVSEFLQDQNATLVSRAPQTFKMDDLLAEMQEIEQSNFRQAPQRAPGVADLALSENWAQEFLAAGDAVDVAQDYNETDWSQEFIAEVTDPLSVSPARWAEEYLEQSEEKLWLGDQEGSSTADRWYDEYHPEEDLQHTASDFVSKVDDPKLANSEFLKFVRQIGEGQVSLESAAGSGGAQAEQWAAEFIQQQGTSEAWVDQFTRPGNKIAALQVEFERAKSAIESDVDFWDKLQAELEEMAKRDAEAHPWLSDYDDLTSASYDKGYQFEEENPLRDHPQPFEEGLHRLEEGDLPNAVLLFEAAVQQDPKHMEAWQYLGTTQAENEQELLAISALRRCLELKPDNRTALMALAVSFTNESLQRQACETLRDWLRYSPAYAHLVAPGEEGATGAGPSKRILGSLLSDSLFLEVKDLFLAAVRLDPTSIDPDVQCGLGVLFNLSGEYDKAVDCFTAALSVRPNDYLMWNKLGATLANGNQSEEAVAAYRRALELQPGYIRSRYNLGISCINLGAHREAVEHFLEALNMQRKSRGPRGEGGAMSENIWSTLRLALSMLGQSDAYGAADARDLSALLAMFGLPQ
Functional category(ies) :	Peroxisome biogenesis (peroxins) Peroxisome targeting sequence binding
Disease(s) :	No diseases found
Comparative genomics:	PTS prediction Alignment Phylogenetic tree [help]
Gene Info:	Gene Summary (NCBI) Genome Browser (UCSC) Chromosomal Localization (NCBI) ENSEMBL Protein Properties (UCSC) Conserved Domains (NCBI) Orthologue Prediction (NCBI)
Pubmed:	Anneleen Janssen, et al.2003. J. Neurosci. Neuronal migration depends on intact peroxisomal function in brain and in extraneuronal tissues. Georg Neuberger, et al.2003. J. Mol. Biol. Prediction of peroxisomal targeting signal 1 containing proteins from amino acid sequence. M Baes, et al.2002. J. Neuropathol. Exp. Neurol. The neuronal migration defect in mice with Zellweger syndrome (Pex5 knockout) is not caused by the inactivity of peroxisomal beta-oxidation. Sietske Hogenboom, et al.2002. J. Lipid Res. Absence of functional peroxisomes does not lead to deficiency of enzymes involved in cholesterol biosynthesis. I Vanhorebeek, et al.2001. Biochim. Biophys. Acta Isoprenoid biosynthesis is not compromised in a Zellweger syndrome mouse model.