Gene : Abcd1

Symbol :	Abcd1
Name/description :	ATP-binding cassette, sub-family D (ALD), member 1
Synonyms :	Ald, ALDP, Aldgh
Organism :	Mus musculus
Peroxisomal Localization :	GO: peroxisomal membrane Miki Kikuchi, et al.2004. J. Biol. Chem. GFP: No experiment found Mass Spectrometry: Miki Kikuchi, et al.2004. J. Biol. Chem. PeroxisomeDB annotation
Protein family :	ABCD
Protein consensus sequence :	PEX19=0.00022; start position=69; end position=78; MPVLSTPRPSRVTTLKRTAVVLALTAYGVHKIYPLVRQCLTPARGPQVPAGEPTQEASGATATKAGMNRVFLQRLLALLRLLFPRVLCRETGLLALHSAALVSRTFLSVYVARLDGRLARCIVRKDPRAFSWQLLQWLLIALPATFINSAIRYLEGQLALSFRSRLVAHAYGLYFSQQTYYRVSNMDGRLRNPDQSLTEDVVAFAASVAHLYSNLTKPLLDVAVTSYTLLRAARSRGAGTAWPSAIAGLVVFLTANVLRAFSPKFGELVAEEARRKGELRYMHSRVVANSEEIAFYGGHEVELALLQHSYQDLASQINLILLERLWYVMLEQFLMKYVWSASGLLMVAVPIITATGYAESDSEAMKKAALEMKEEELVSERTEAFTIARNLLTAAADATERIMSSYKEVTELAGYTARVYEMFQVFEDVKHCRFKRTGDLEEAQAGPGVMVQSGVHVEGPLKIQGQVVDVEQGIICENIPIITPTGEVVVASLNIRVEEGMHLLITGPNGCGKSSLFRILGGLWPTYSGVLYKPPPQRMFYIPQRPYMSVGSLRDQVIYPDSAEDMRRKGCSEQQLEAILGIVHLRHILQREGGWEAVCDWKDVLSGGEKQRIGMARMFYHRPKYALLDECTSAVSIDVEGKIFQAAKDAGIALLSITHRPSLWKYHTHLLQFDGEGGWKFEKLDSAARLSLTEEKQRLEQQLAGIPKMQGRLQELRQILGEAAAPVQPLVPGVPT
Functional category(ies) :	ABC transporters Di- trihydroxycholestanoic acid oxidation/Bile acid synthesis Fatty acid oxidation Fatty acid synthesis/PUFAS synthesis Lipid metabolism Peroxisomal membrane proteins (PMP) Straight chain fatty acids oxidation
Disease(s) :	No diseases found
Comparative genomics:	PTS prediction Alignment Phylogenetic tree [help]
Gene Info:	Gene Summary (NCBI) Genome Browser (UCSC) Chromosomal Localization (NCBI) ENSEMBL Protein Properties (UCSC) Conserved Domains (NCBI) Orthologue Prediction (NCBI)
Pubmed:	Pedro Brites, et al.2009. Brain Plasmalogens participate in very-long-chain fatty acid-induced pathology. Stéphane Fourcade, et al.2008. Hum. Mol. Genet. Early oxidative damage underlying neurodegeneration in X-adrenoleukodystrophy. Johannes Berger, et al.2006. Biochim. Biophys. Acta X-linked adrenoleukodystrophy: clinical, biochemical and pathogenetic aspects. Aurora Pujol, et al.2004. Hum. Mol. Genet. Functional overlap between ABCD1 (ALD) and ABCD2 (ALDR) transporters: a therapeutic target for X-adrenoleukodystrophy. Aurora Pujol, et al.2002. Hum. Mol. Genet. Late onset neurological phenotype of the X-ALD gene inactivation in mice: a mouse model for adrenomyeloneuropathy. S Kemp, et al.1998. Nat. Med. Gene redundancy and pharmacological gene therapy: implications for X-linked adrenoleukodystrophy.