Gene : Pex6

Symbol :	Pex6
Name/description :	peroxisomal biogenesis factor 6
Synonyms :	Paf2, Paf-2
Organism :	Rattus norvegicus
Peroxisomal Localization :	GO: peroxisomal membrane T Tsukamoto, et al.1995. Nat. Genet. Miki Kikuchi, et al.2004. J. Biol. Chem. GFP: No experiment found Mass Spectrometry: No experiment found PeroxisomeDB annotation
Protein family :	PEX6
Protein consensus sequence :	MALAVLHVLEPFPTETPPLAVLLPPGGPWPVTGVGLVLALRPASESPAGPALLVAAVEGSGAQCEQRGPGPPPLLVSRTLLRVLALSPGARVRARPVRRPPALGWALLGTSPGPGLGPRVGPLLVRRGETLPVPGSRVLETRPALQGLLGPGTRLAVTELQGRTKLDPESRDHNHPPPPPVVSSFAVSHSIRQLRGVLGGTGDALGVSRSCLRSLGLFQGEWVWVARVGELPNTSQPHLAQVQVLEPRWDLSARLGPNSGQPGEPLADGLVFVPATLAFNLGCDPLEVGELRIQRYLEDSTAAEDKGSCSLLPGPPFARELHIEVLPSPHCGVNGKYDHVLYQHFHTPRVVQEGDVLCVSTAGQVEILEGSLERLPR
Functional category(ies) :	Peroxisomal AAA-ATPases Peroxisome biogenesis (peroxins)
Disease(s) :	No diseases found
Comparative genomics:	PTS prediction Alignment Phylogenetic tree [help]
Gene Info:	Gene Summary (NCBI) Genome Browser (UCSC) Chromosomal Localization (NCBI) ENSEMBL Protein Properties (UCSC) Conserved Domains (NCBI) Orthologue Prediction (NCBI)
Pubmed:	Inderjit Singh, et al.2004. Brain Res. Impaired peroxisomal function in the central nervous system with inflammatory disease of experimental autoimmune encephalomyelitis animals and protection by lovastatin treatment. Naomi Matsumoto, et al.2003. Nat. Cell Biol. The pathogenic peroxin Pex26p recruits the Pex1p-Pex6p AAA ATPase complexes to peroxisomes. Noriyo Hashiguchi, et al.2002. Mol. Biol. Cell Peroxisomes are formed from complex membrane structures in PEX6-deficient CHO cells upon genetic complementation. Z Zhang, et al.1999. Hum. Mutat. Genomic structure and identification of 11 novel mutations of the PEX6 (peroxisome assembly factor-2) gene in patients with peroxisome biogenesis disorders. N Kinoshita, et al.1998. J. Biol. Chem. Newly identified Chinese hamster ovary cell mutants are defective in biogenesis of peroxisomal membrane vesicles (Peroxisomal ghosts), representing a novel complementation group in mammals.