Gene : PEX7

Symbol :	PEX7
Name/description :	Peroxisomal signal receptor for the N-terminal nonapeptide signal (PTS2) of peroxisomal matrix proteins; WD repeat protein; defects in human homolog cause lethal rhizomelic chondrodysplasia punctata (RCDP) Pex7p
Synonyms :	PEB1, PAS7
Organism :	Saccharomyces cerevisiae
Peroxisomal Localization :	GO: peroxisome Zhang Zhang, et al.1996. J. Cell Biol. P Rehling, et al.1996. EMBO J. W Girzalsky, et al.1999. J. Cell Biol. Nair Nair, et al.2004. J. Cell Biol. GFP: No experiment found Mass Spectrometry: Marcello Yi, et al.2002. Electrophoresis PeroxisomeDB annotation
Protein family :	PEX7
Protein consensus sequence :	MLRYHMQGFSGYGVQYSPFFDNRLAVAAGSNFGLVGNGKLFILEIDRSGRIVEVNSFLTQDCLFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWNGLG
Functional category(ies) :	Peroxisome biogenesis (peroxins) Peroxisome targeting sequence binding
Disease(s) :	No diseases found
Comparative genomics:	PTS prediction Blastp PsiBlast Alignment Phylogenetic tree [help] PhylomeDB
Gene Info:	Gene Summary (NCBI) Genome Browser (UCSC) Chromosomal Localization (NCBI) ENSEMBL Protein Properties (UCSC) Conserved Domains (NCBI) Orthologue Prediction (NCBI)
Pubmed:	Nair Nair, et al.2004. J. Cell Biol. Pex7p translocates in and out of peroxisomes in Saccharomyces cerevisiae. Satoru Mukai, et al.2002. J. Biol. Chem. Intracellular localization, function, and dysfunction of the peroxisome-targeting signal type 2 receptor, Pex7p, in mammalian cells. G Dodt, et al.2001. J. Biol. Chem. Domain mapping of human PEX5 reveals functional and structural similarities to Saccharomyces cerevisiae Pex18p and Pex21p. Lee Lee, et al.2000. J. Biochem. Identification of a cryptic N-terminal signal in Saccharomyces cerevisiae peroxisomal citrate synthase that functions in both peroxisomal and mitochondrial targeting. Y Elgersma, et al.1998. J. Cell Biol. A mobile PTS2 receptor for peroxisomal protein import in Pichia pastoris.