Gene : PEX5

Symbol :	PEX5
Name/description :	Peroxisomal membrane signal receptor for the C-terminal tripeptide signal sequence (PTS1) of peroxisomal matrix proteins, required for peroxisomal matrix protein import; also proposed to have PTS1-receptor independent functions <
Synonyms :	PAS10
Organism :	Saccharomyces cerevisiae
Peroxisomal Localization :	GO: peroxisome C Brocard, et al.1994. Biochem. Biophys. Res. Commun. Y Elgersma, et al.1996. J. Cell Biol. P Klein, et al.2001. J. Biol. Chem. Astrid Kragt, et al.2005. J. Biol. Chem. Daniela Kerssen, et al.2006. J. Biol. Chem. GFP: Klaus Natter, et al.2005. Mol. Cell PROTEOMICS Won-Ki Huh, et al.2003. Nature Marcello Yi, et al.2002. Electrophoresis Mass Spectrometry: No experiment found PeroxisomeDB annotation
Protein family :	PEX5
Protein consensus sequence :	MDVGSCSVGNNPLAQLHKHTQQNKSLQFNQKNNGRLNESPLQGTNKPGISEAFISNVNAISQENMANMQRFINGEPLIDDKRRMEIGPSSGRLPPFSNVHSLQTSANPTQIKGVNDISHWSQEFQGSNSIQNRNADTGNSEKAWQRGSTTASSRFQYPNTMMNNYAYASMNSLSGSRLQSPAFMNQQQSGRSKEGVNEQEQQPWTDQFEKLEKEVSENLDINDEIEKEENVSEVEQNKPETVEKEEGVYGDQYQSDFQEVWDSIHKDAEEVLPSELVNDDLNLGEDYLKYLGGRVNGNIEYAFQSNNEYFNNPNAYKIGCLLMENGAKLSEAALAFEAAVKEKPDHVDAWLRLGLVQTQNEKELNGISALEECLKLDPKNLEAMKTLAISYINEGYDMSAFTMLDKWAETKYPEIWSRIKQQDDKFQKEKGFTHIDMNAHITKQFLQLANNLSTIDPEIQLCLGLLFYTKDDFDKTIDCFESALRVNPNDELMWNRLGASLANSNRSEEAIQAYHRALQLKPSFVRARYNLAVSSMNIGCFKEAAGYLLSVLSMHEVNTNNKKGDVGSLLNTYNDTVIETLKRVFIAMNRDDLLQEVKPGMDLKRFKGEFSF
Functional category(ies) :	Peroxisome biogenesis (peroxins) Peroxisome targeting sequence binding
Disease(s) :	No diseases found
Comparative genomics:	PTS prediction Blastp PsiBlast Alignment Phylogenetic tree [help] PhylomeDB
Gene Info:	Gene Summary (NCBI) Genome Browser (UCSC) Chromosomal Localization (NCBI) ENSEMBL Protein Properties (UCSC) Conserved Domains (NCBI) Orthologue Prediction (NCBI)
Pubmed:	Sebastian Grou, et al.2008. J. Biol. Chem. Members of the E2D (UbcH5) family mediate the ubiquitination of the conserved cysteine of Pex5p, the peroxisomal import receptor. Chris Williams, et al.2007. J. Biol. Chem. A conserved cysteine is essential for Pex4p-dependent ubiquitination of the peroxisomal import receptor Pex5p. Fouzi Platta, et al.2007. J. Cell Biol. Ubiquitination of the peroxisomal import receptor Pex5p is required for its recycling. Matthias Stanley, et al.2006. Biochim. Biophys. Acta Dynamic architecture of the peroxisomal import receptor Pex5p. Chris Williams, et al.2006. Biochim. Biophys. Acta Pex13p: docking or cargo handling protein?