Gene : PEX10

Symbol :	PEX10
Name/description :	C3HC4-type RING-finger peroxisomal membrane peroxin required for peroxisomal matrix protein import, interacts with Pex12p, links ubiquitin-conjugating Pex4p to import machinery; mutations in human homolog cause various peroxisomal disorders
Synonyms :	PAS4
Organism :	Saccharomyces cerevisiae
Peroxisomal Localization :	GO: peroxisomal membrane Nils Eckert, et al.2003. J. Cell. Sci. Kerstin Kiel, et al.2005. J. Biol. Chem. GFP: Klaus Natter, et al.2005. Mol. Cell PROTEOMICS Won-Ki Huh, et al.2003. Nature Mass Spectrometry: No experiment found PeroxisomeDB annotation
Protein family :	PEX10
Protein consensus sequence :	MKNDNKLQKEALMRLSQLRFPFADAPSIVQAHQKDEQIQGLLIMKVTELCKLIKSQLFVNSYPKELSIFAKLLYLLFTTGRRGRTLGEEYVDLTYTNRKGTRLAGRLKMIVFAFAYPLCPYFITKLYKKIMKNNKESKIEDTESVAAFCKGLLDFILDVHMTLFYFKGAFYSISKRIFGMRYVFKHILSKNEANFREEGSQKYKVLGYILLAQNVMKWYPVLTSTLGSWIYGRKRTNDSITRSSVGLQERSEHESIEGIPKESQLTHINLSDKNQLPFIPEASRKCILCLMNMSDPSCAPCGHLFCWSCLMSWCKERPECPLCRQHCQPQEILVLRQ
Functional category(ies) :	Peroxisome matrix protein import ZN RING proteins
Disease(s) :	No diseases found
Comparative genomics:	PTS prediction Blastp PsiBlast Alignment Phylogenetic tree [help] PhylomeDB
Gene Info:	Gene Summary (NCBI) Genome Browser (UCSC) Chromosomal Localization (NCBI) ENSEMBL Protein Properties (UCSC) Conserved Domains (NCBI) Orthologue Prediction (NCBI)
Pubmed:	Tracy Saveria, et al.2007. Eukaryotic Cell Conservation of PEX19-binding motifs required for protein targeting to mammalian peroxisomal and trypanosome glycosomal membranes. Nils Eckert, et al.2003. J. Cell. Sci. Pex10p links the ubiquitin conjugating enzyme Pex4p to the protein import machinery of the peroxisome. Birgit Agne, et al.2003. Mol. Cell Pex8p: an intraperoxisomal organizer of the peroxisomal import machinery. A Snyder, et al.1999. Mol. Biol. Cell Pex19p interacts with Pex3p and Pex10p and is essential for peroxisome biogenesis in Pichia pastoris. D Warren, et al.1998. Am. J. Hum. Genet. Identification of PEX10, the gene defective in complementation group 7 of the peroxisome-biogenesis disorders.