Gene : PEX12

Symbol :	PEX12
Name/description :	C3HC4-type RING-finger peroxisomal membrane peroxin required for peroxisome biogenesis and peroxisomal matrix protein import; forms translocation subcomplex with Pex2p and Pex10p; mutations in human homolog cause peroxisomal disorders
Synonyms :	PAS11
Organism :	Saccharomyces cerevisiae
Peroxisomal Localization :	GO: integral to peroxisomal membrane M Albertini, et al.2001. Eur. J. Cell Biol. Kerstin Kiel, et al.2005. J. Biol. Chem. GFP: Won-Ki Huh, et al.2003. Nature Marcello Yi, et al.2002. Electrophoresis Mass Spectrometry: No experiment found PeroxisomeDB annotation
Protein family :	PEX12
Protein consensus sequence :	PEX19=0.0033; start position=188; end position=197; PEX19=0.057; start position=198; end position=207; PEX19=0.073; start position=276; end position=285; MSFYSNLPSAGQSSRGSSTSGRNGVGLEPLYPTIFEIMSSQEIDSLLPASIRYLLANHLVANFPNRYTLRLNKYFFEWFQAIKGFVEWYHLKTYNSTFIDRFYGLQLFSSRDRNLALTQCLNPKGQSEWPQGLQLNQQQKSVIFLEKIILPYITAKLDEILEKISMNNIFSSDETENKWPKRAFLRIYPFIKKLLALSNLLVKLLFLTKRTGSVSLLQYLFKIEYTTVRPLSSELSGLKETKGMDNRLRKTNISSIFALMQGQLSIIPRFLTFMGSQFFPTFIFVLRVYQWWTTQDMTTKLQKRVNDLDEDIPRPPFSSHSDKTEDKEGVSEACPVCEKTVQNPCVLETGYVACYPCAISYLVNNEGHCPVTNKKLLGCTYNKHTNKWEVVTGIRKLLI
Functional category(ies) :	Peroxisome matrix protein import ZN RING proteins
Disease(s) :	No diseases found
Comparative genomics:	PTS prediction Blastp PsiBlast Alignment Phylogenetic tree [help] PhylomeDB
Gene Info:	Gene Summary (NCBI) Genome Browser (UCSC) Chromosomal Localization (NCBI) ENSEMBL Protein Properties (UCSC) Conserved Domains (NCBI) Orthologue Prediction (NCBI)
Pubmed:	Tracy Saveria, et al.2007. Eukaryotic Cell Conservation of PEX19-binding motifs required for protein targeting to mammalian peroxisomal and trypanosome glycosomal membranes. Nils Eckert, et al.2003. J. Cell. Sci. Pex10p links the ubiquitin conjugating enzyme Pex4p to the protein import machinery of the peroxisome. Birgit Agne, et al.2003. Mol. Cell Pex8p: an intraperoxisomal organizer of the peroxisomal import machinery. M Albertini, et al.2001. Eur. J. Cell Biol. Pex12p of Saccharomyces cerevisiae is a component of a multi-protein complex essential for peroxisomal matrix protein import.