Gene : MVK

Symbol :	MVK
Name/description :	mevalonate kinase
Synonyms :	MK, LRBP, MVLK, FLJ96772
Organism :	Homo sapiens
Peroxisomal Localization :	GO: No Peroxisomal annotation GFP: No experiment found Mass Spectrometry: No experiment found PeroxisomeDB annotation
Protein family :	MVK
Protein consensus sequence :	MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKRAWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDMNQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQALTSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL
Functional category(ies) :	Isoprenoid metabolism Metabolism
Disease(s) :	No diseases found
Comparative genomics:	PTS prediction Blastp PsiBlast Alignment Phylogenetic tree [help] PhylomeDB Enzyme reaction data
Gene Info:	Gene Summary (NCBI) Genome Browser (UCSC) Chromosomal Localization (NCBI) ENSEMBL Protein Properties (UCSC) Conserved Domains (NCBI) Orthologue Prediction (NCBI)
Pubmed:	Sietske Hogenboom, et al.2004. J. Cell. Sci. Mevalonate kinase is a cytosolic enzyme in humans. Sietske Hogenboom, et al.2003. Mol. Genet. Metab. Cholesterol biosynthesis is not defective in peroxisome biogenesis defective fibroblasts. G Rothardt, et al.2001. Cell. Mol. Life Sci. Peroxisomes in the apocrine sweat glands of the human axilla and their putative role in pheromone production. Olivier Olivier, et al.2000. Biochim. Biophys. Acta Peroxisomal protein targeting and identification of peroxisomal targeting signals in cholesterol biosynthetic enzymes. Houten Houten, et al.2000. Biochim. Biophys. Acta Biochemical and genetic aspects of mevalonate kinase and its deficiency.