Name : | ABC transporters | ||||||||||
Organism : | Canis familiaris | ||||||||||
Description : | Transporters that include the ATP Binding Cassette (ABC). All known peroxisomes have at least one ABC transporter, therefore are highly conserved throughout the evolution. For example, in mammals, there are 4 peroxisomal ABC transporters: ABCD1, ABCD2, ABCD3 and ABCD4. Lack of function of ABCD1, or Ald, causes a severe human disease: the X-linked Adrenoleukodystrophy. | ||||||||||
Gene(s) : |
| ||||||||||
Disease(s) : | |||||||||||
Image(s) : | |||||||||||
Database link(s) : |
Lipid metabolism
Move your mouse pointer on the image, it will change form on clickable areas
Phylogenetic tree of ABCDs. The philogenetic distribution for ABCD1, ABCD2, ABCD3, ABCD4, and the fungal PXA1 and PXA2 is displayed. The scale length indicates 0.5 substitutions per site. The incomplete sequences are not represented in order to show reliability of the phylogenetic distribution. Human: H. sapiens, Chimp: P. troglodytes, Dog: C. familiaris, Cow: B. Taurus, Mouse: M. musculus, Rat: R. norvegicus, Chicken: G. gallus, Tetra: T. nigroviridis, Fugu: T. rubripes, Zebraf: D. rerio, Frog: X. tropicalis, Ciona: C. intestinalis, Cele: C. elegans, Brig: C. briggsae, Honeybee: A. mellifera, Mosquito: A. gambiae, Ylipo: Y. lipolytica, Afum: A. fumigatus, Ncras: N. crassa, Pchry: P. chrysosporium, Cneo: C. neoformans, Dhans: D. hansenii, Klac: K. lactis, Egos: E. gossypii, Scer: S. cerevisiae, Cgla: C. glabrata, Lmajor: L. major, Ddisc: D. discoïdeum, Cmer: C. merolae, Rice: O. sativa, Atha: A. thaliana, Tpseu: T. pseudonana.