Functional category : ABC transporters

Name : ABC transporters
Organism : Equus caballus
Description : Transporters that include the ATP Binding Cassette (ABC). All known peroxisomes have at least one ABC transporter, therefore are highly conserved throughout the evolution. For example, in mammals, there are 4 peroxisomal ABC transporters: ABCD1, ABCD2, ABCD3 and ABCD4. Lack of function of ABCD1, or Ald, causes a severe human disease: the X-linked Adrenoleukodystrophy.
Gene(s) :
GENE PROTEIN FAMILY
ABCD4
LOC100058542
LOC100058868
LOC100069405
LOC100069937
LOC100147626
Disease(s) :
Image(s) :
Database link(s) :

[top] Image description : Lipid metabolism

Lipid metabolism
Move your mouse pointer on the image, it will change form on clickable areas
Lipid-metabolism.jpg


[top] Image description : Phylogenetic tree of ABCDs

Phylogenetic tree of ABCDs
ABCDtree.jpg

Phylogenetic tree of ABCDs. The philogenetic distribution for ABCD1, ABCD2, ABCD3, ABCD4, and the fungal PXA1 and PXA2 is displayed. The scale length indicates 0.5 substitutions per site. The incomplete sequences are not represented in order to show reliability of the phylogenetic distribution. Human: H. sapiens, Chimp: P. troglodytes, Dog: C. familiaris, Cow: B. Taurus, Mouse: M. musculus, Rat: R. norvegicus, Chicken: G. gallus, Tetra: T. nigroviridis, Fugu: T. rubripes, Zebraf: D. rerio, Frog: X. tropicalis, Ciona: C. intestinalis, Cele: C. elegans, Brig: C. briggsae, Honeybee: A. mellifera, Mosquito: A. gambiae, Ylipo: Y. lipolytica, Afum: A. fumigatus, Ncras: N. crassa, Pchry: P. chrysosporium, Cneo: C. neoformans, Dhans: D. hansenii, Klac: K. lactis, Egos: E. gossypii, Scer: S. cerevisiae, Cgla: C. glabrata, Lmajor: L. major, Ddisc: D. discoïdeum, Cmer: C. merolae, Rice: O. sativa, Atha: A. thaliana, Tpseu: T. pseudonana.