Functional category : Alpha-oxidation

Name : Alpha-oxidation
Organism : Equus caballus
Description : This function is present in vertebrates and in Caenorhabditis elegans is predicted. The alpha-oxidation removes the terminal carboxyl group as CO2 displacing the 3-methyl, in 3-methyl-branched fatty acids, to a position that allows the following beta-oxidation steps. One of the most important 3-methyl branched fatty acid is phytanic acid. Enzymes involved in the alpha-oxidation:

a) FACL1 or LACS: activates phytanic acid to phytanoyl-CoA,

b) PHYH: hydroxylates the phytanoyl CoA,

c) HPCL2: decarboxylates to pristanal,

d) pristanalDH: dehydrogenates pristanal to pristanic,

e) VLACS: activates pristanic to prystanoyl-CoA,

f) IDH1: produces oxoglutarate used by PhyH.

Gene(s) :
GENE PROTEIN FAMILY
IDH1
LOC100056651
LOC100063461
LOC100063920
LOC100069176
SLC27A2
SLC27A4
Disease(s) :
Image(s) :

[top] Image description : Alpha oxidation

Alpha oxidation
Alpha-oxidation.png


[top] Image description : Lipid metabolism

Lipid metabolism
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Lipid-metabolism.jpg