Functional category : Glyoxylate and dicarboxylate metabolism

Name : Glyoxylate and dicarboxylate metabolism
Organism : Leishmania major
Description : Glyoxylate cycle allows the synthesis of macromolecules from dicarboxylates compounds such as ethanol and acetate. Metazoans in general, including humans, use glucose as the main carbon source and lack this cycle. Yeasts, plants and trypanosomatids have this cycle. In humans,the glyoxylate is a toxic metabolite wich undergoes oxalate formation. The oxalate precipitates as calcium oxalate with severe consequences for the tissues involved. Under normal conditions oxalate is converted to glycine by glyoxylate aminotransferase (AGT).
Gene(s) :
GENE PROTEIN FAMILY
LmjF10.0290
LmjF18.0670
LmjF18.0680
LmjF19.0710
LmjF24.0320
LmjF27.1805
LmjF34.0140
LmjF34.0150
LmjF34.0160
LmjF35.1180
Disease(s) : No diseases found
Image(s) :

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Glyoxylate and dicarboxylate metabolism
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Glyoxylate-and-dicarboxylate-metabolism.jpg