Gene : PMVK

Symbol :	PMVK
Name/description :	phosphomevalonate kinase
Synonyms :	PMK, PMKA, PMKASE, HUMPMKI
Organism :	Homo sapiens
Peroxisomal Localization :	GO: peroxisome Olivier Olivier, et al.1999. J. Lipid Res. GFP: No experiment found Mass Spectrometry: No experiment found PeroxisomeDB annotation
Protein family :	PMVK
Protein consensus sequence :	MAPLGGAPRLVLLFSGKRKSGKDFVTEALQSRLGADVCAVLRLSGPLKEQYAQEHGLNFQRLLDTSTYKEAFRKDMIRWGEEKRQADPGFFCRKIVEGISQPIWLVSDTRRVSDIQWFREAYGAVTQTVRVVALEQSRQQRGWVFTPGVDDAESECGLDNFGDFDWVIENHGVEQRLEEQLENLIEFIRSRL
Functional category(ies) :	Isoprenoid metabolism Metabolism
Disease(s) :	No diseases found
Comparative genomics:	PTS prediction Blastp PsiBlast Alignment Phylogenetic tree [help] PhylomeDB Enzyme reaction data
Gene Info:	Gene Summary (NCBI) Genome Browser (UCSC) Chromosomal Localization (NCBI) ENSEMBL Protein Properties (UCSC) Conserved Domains (NCBI) Orthologue Prediction (NCBI)
Pubmed:	Xueying Kovacs, et al.2007. Histochem. Cell Biol. Localization of the pre-squalene segment of the isoprenoid biosynthetic pathway in mammalian peroxisomes. Sietske Hogenboom, et al.2004. J. Lipid Res. Phosphomevalonate kinase is a cytosolic protein in humans. Sietske Hogenboom, et al.2003. Mol. Genet. Metab. Cholesterol biosynthesis is not defective in peroxisome biogenesis defective fibroblasts. Olivier Olivier, et al.2000. Biochim. Biophys. Acta Peroxisomal protein targeting and identification of peroxisomal targeting signals in cholesterol biosynthetic enzymes. R Chambliss, et al.1996. J. Biol. Chem. Molecular cloning of human phosphomevalonate kinase and identification of a consensus peroxisomal targeting sequence.