Gene : PEX15

Symbol :	PEX15
Name/description :	Pex15p Phosphorylated tail-anchored type II integral peroxisomal membrane protein required for peroxisome biogenesis, cells lacking Pex15p mislocalize peroxisomal matrix proteins to cytosol, overexpression result
Synonyms :	PAS21
Organism :	Saccharomyces cerevisiae
Peroxisomal Localization :	GO: integral to peroxisomal membrane Y Elgersma, et al.1997. EMBO J. Silke Platta, et al.2005. Nat. Cell Biol. GFP: No experiment found Mass Spectrometry: Marcello Yi, et al.2002. Electrophoresis PeroxisomeDB annotation
Protein family :	PEX15
Protein consensus sequence :	PEX19=0.0012; start position=136; end position=145; PEX19=0.016; start position=337; end position=346; PEX19=0.058; start position=340; end position=349; PEX19=0.066; start position=370; end position=379; MAASEIMNNLPMHSLDSSLRDLLNDDLFIESDESTKSVNDQRSEVFQECVNLFIKRDIKDCLEKMSEVGFIDITVFKSNPMILDLFVSACDIMPSFTKLGLTLQSEILNIFTLDTPQCIETRKIILGDLSKLLVINKFFRCCIKVIQFNLTDHTEQEEKTLELESIMSDFIFVYITKMRTTIDVVGLQELIEIFIFQVKVKLHHKKPSPNMYWALCKTLPKLSPTLKGLYLSKDVSIEDAILNSIDNKIQKDKAKSKGKQRGVKQKIHHFHEPMLHNSSEEQVKVEDAFNQRTSTDSRLQSTGTAPRKKNNDITVLAGSFWAVLKHHFTRSVLNKNGLLLTGLLLLLCLKKYKSLMAIFKHVPAAFHTVYPQIVGLLKLLASI
Functional category(ies) :	Peroxisome biogenesis (peroxins) Peroxisome matrix protein import Peroxisome membrane assembly
Disease(s) :	No diseases found
Comparative genomics:	PTS prediction Blastp PsiBlast Alignment Phylogenetic tree [help] PhylomeDB
Gene Info:	Gene Summary (NCBI) Genome Browser (UCSC) Chromosomal Localization (NCBI) ENSEMBL Protein Properties (UCSC) Conserved Domains (NCBI) Orthologue Prediction (NCBI)
Pubmed:	Silke Platta, et al.2005. Nat. Cell Biol. Functional role of the AAA peroxins in dislocation of the cycling PTS1 receptor back to the cytosol. Astrid Kragt, et al.2005. J. Biol. Chem. The Saccharomyces cerevisiae peroxisomal import receptor Pex5p is monoubiquitinated in wild type cells. Ingvild Birschmann, et al.2003. Mol. Biol. Cell Pex15p of Saccharomyces cerevisiae provides a molecular basis for recruitment of the AAA peroxin Pex6p to peroxisomal membranes. R Kunau, et al.1998. Curr. Biol. Peroxisome biogenesis: back to the endoplasmic reticulum? Y Elgersma, et al.1997. EMBO J. Overexpression of Pex15p, a phosphorylated peroxisomal integral membrane protein required for peroxisome assembly in S.cerevisiae, causes proliferation of the endoplasmic reticulum membrane.