||Glyoxylate cycle allows the synthesis of macromolecules from dicarboxylates compounds such as ethanol and acetate. Metazoans in general, including humans, use glucose as the main carbon source and lack this cycle. Yeasts, plants and trypanosomatids have this cycle. In humans,the glyoxylate is a toxic metabolite wich undergoes oxalate formation. The oxalate precipitates as calcium oxalate with severe consequences for the tissues involved. Under normal conditions oxalate is converted to glycine by glyoxylate aminotransferase (AGT).