2819 proteins in 38 organisms
Peroxisomes are single-membrane subcellular organelles, present in most eukaryotic cells and organisms.
The Peroxisome fulfills essential metabolic functions in lipid metabolism, both catabolic (oxidation of pipecolic, phytanic and very-long chain fatty acids) and anabolic (synthesis of plasmalogens and bile acids). Moreover, the peroxisome plays a key role in free radical detoxification, differentiation, development and morphogenesis from human to yeast. Fatal disorders are related to defective peroxisomal function or biogenesis.
The aim of PEROXISOME database (PeroxisomeDB) is to gather, organise and integrate curated information on peroxisomal genes, their encoded proteins, their molecular function and metabolic pathway they belong to, and their related disorders. PeroxisomeDB contains the complete peroxisomal proteome of Homo sapiens (encoded by 85 genes) and Saccharomyces cerevisiae (encoded by 61 genes). Now, we have included 34 organism genomes with the acquisition of 2426 peroxisomal homolog proteins. PeroxisomeDB 2.0 integrates the peroxisomal metabolome of whole microbody familiy by the incorporation of the glycosome proteomes of trypanosomatids and the glyoxysome proteome of Arabidopsis thaliana.
In PeroxisomeDB you will find:
1. Peroxisome Metabolome of peroxisomal genes and proteins, their molecular interactions and metabolic pathways.
2. Comparative genomics: orthologue prediction and automatic retrieval of phylogenetic alignments and tree building for each gene.
- 3. Peroxisome related disease: a total of 22 disorders, sorted by clinical criteria and classified into two main groups.
- 3.1 peroxisome biogenesis disorders (PBD), and
- 3.2 single peroxisomal protein deficiencies.
- 4. Predictive tools:
For didactic purposes, PeroxisomeDB contains graphical depictions of the main peroxisomal metabolic pathways, as well as comprehensible flow charts for diagnosis.
PeroxisomeDB aims at becoming a useful tool for basic researchers and clinicians working on peroxisomes and metabolic disease.
Schluter, A., Real-Chicharro, A., Gabaldon, T., Sanchez-Jimenez, F. and Pujol, A. (2010) PeroxisomeDB 2.0: an integrative view of the global peroxisomal metabolome. Nucleic Acids Res, 38, D800-5.